@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28270: (2016-07-14 )
MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIGGAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLFANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKLEHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTRDLARSEEFSSTQAITEEVKAAIMSENTISNV
Atome Classification :
(51 SA)
.........10........20........30......------..40........---50.........60...-.-....70........80---.....-....90-........100.......110.......120.-.-..-...130.......140..-------.....150----...----.-....160.......170.......180.-------------...-...190.....-..200....---....210-.........220.......230.......240.......250.......260.......270.........280.......290.......300...------..-..310......--.320--........330-.-......-.340--......-------..350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
R
I
A
LLPGDGI
G
P
E
V
L
E
S
A
T
D
V
L
K
S
V
A
E
RFNH
E
F
E
------
F
E
YGLIG
G
A
AID---E-HHNPL
P
E
E
T
V
A
A
CK-N-A
D
A
I
L
L
GAVGGPKWD----Q
N
P
S
E-LR
P
E
K
G
-
L
L
S
I
R
K
Q
L
D
L
F
ANL
R
P
V
K
V
F
E
S
LSDASP
L
K
K
E
-Y-ID-NV
D
F
V
I
V
R
E
LTGGLYFGQ-------PSKRYVN-----TEG----
E
-
Q
E
A
V
D
T
L
F
Y
K
R
T
E
I
E
R
V
I
R
E
G
F
K
M
A
AAR-------------KGK-VTSV
D
K
A
N
V
L
E
-
S
S
R
-
L
W
R
E
V
---
A
E
D
V
A
---
Q
EFPD
V
K
L
E
H
M
LVDN
A
A
M
Q
L
I
YAPN
Q
F
D
V
V
V
T
E
N
M
F
G
D
I
LSD
E
A
S
M
L
TGSLGMLPSASLS--SSG
L
H
L
FEPVHGSAPDIAGKGMA
N
P
F
A
A
I
L
S
A
A
M
L
------
L
R
-TSFG
L
E
E
E
A
K
A
--
V
E
D
---
A
V
N
K
V
L
ASG-K-R-
T
R
D
L
A
R
-
S
EE---FS
S
T
Q
A
-------
I
T
E
E
V
K
A
A
I
MSENTISNV
1
PsiBlast_PDB
92.35
75%
-87
- C5 -
3U1H
-
?
A:
[3-364]
--
K
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
F
E
------
F
E
Y
G
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
V
C
R
-
G
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
Q
N
P
S
E
-
L
R
P
E
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
-
I
E
-
G
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
---------------------
E
E
G
----
E
-
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
R
-------------
K
K
K
-
V
T
S
V
D
K
A
N
V
L
E
-
S
S
R
-
L
W
R
E
V
---
A
E
E
V
A
---
K
E
Y
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
--
T
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
------
L
R
-
Y
S
F
G
L
E
E
E
A
K
A
--
I
E
K
---
A
V
E
K
V
L
A
E
G
-
Y
-
R
-
T
A
D
I
A
K
P
G
G
K
---
Y
V
S
T
T
E
-------
M
T
D
E
V
K
A
A
V
V
D
E
L
A
T
S
A
I
119
HHSearch
92.33
77%
-88
- C5 -
3U1H
-
?
A:
[3-363]
--
K
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
F
E
------
F
E
Y
G
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
V
C
R
-
G
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
Q
N
P
S
E
-
L
R
P
E
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
-
I
E
-
G
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
--------------
E
-------
E
G
----
E
-
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
R
-------------
K
K
K
-
V
T
S
V
D
K
A
N
V
L
E
-
S
S
R
-
L
W
R
E
V
---
A
E
E
V
A
---
K
E
Y
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
--
T
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
------
L
R
-
Y
S
F
G
L
E
E
E
A
K
A
--
I
E
K
---
A
V
E
K
V
L
A
E
G
-
Y
-
R
-
T
A
D
I
A
K
-
P
G
G
K
--
Y
V
S
T
T
E
-------
M
T
D
E
V
K
A
A
V
V
D
E
L
A
T
S
A
-
29
PsiBlast_CBE
85.64
54%
-100
- C5 -
1A05
4
LEU3_ACIFR
B:
[2-334]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
------
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
-
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
----
A
Y
P
P
A
-
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
-------
P
R
G
L
E
V
------
I
D
G
----
K
-
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-------------
R
K
Q
-
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
-
L
W
R
E
V
---
V
T
E
V
A
---
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
---
G
E
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
------
L
R
-
H
S
L
N
A
E
P
W
A
Q
R
--
V
E
A
---
A
V
Q
R
V
L
D
Q
G
-
L
-
R
-
T
A
D
I
A
---------------------------------------
116
HHSearch
85.34
53%
-87
- C5 -
1A05
4
LEU3_ACIFR
A:
[1-357]
-
M
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
------
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
-
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
----
A
Y
P
P
A
-
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
-------
P
R
G
L
E
V
I
------
D
G
----
K
-
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-------------
R
K
Q
-
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
-
L
W
R
E
V
---
V
T
E
V
A
---
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
--
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
------
L
R
-
H
S
L
N
A
E
P
W
A
Q
R
--
V
E
A
---
A
V
Q
R
V
L
D
Q
G
-
L
-
R
-
T
A
D
I
A
A
-
P
G
T
P
--
V
I
G
T
K
A
-------
M
G
A
A
V
V
N
A
L
N
L
K
------
3
PsiBlast_PDB
85.13
65%
-90
- C5 -
2AYQ
-
LEU3_BACCO
A:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
S
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
23
PsiBlast_CBE
85.09
65%
-92
- C5 -
1V5B
1
LEU3_BACCO
D:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
8
PsiBlast_PDB
84.98
54%
-99
- C5 -
1A05
4
LEU3_ACIFR
A:
[2-334]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
------
C
T
E
G
L
V
G
G
A
A
L
D
---
A
-
S
D
D
P
L
P
A
A
S
L
Q
L
A
M
-
A
-
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
----
A
Y
P
P
A
-
K
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
-------
P
R
G
L
E
V
------
I
D
G
----
K
-
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-------------
R
K
Q
-
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
-
L
W
R
E
V
---
V
T
E
V
A
---
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
---
G
E
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
------
L
R
-
H
S
L
N
A
E
P
W
A
Q
R
--
V
E
A
---
A
V
Q
R
V
L
D
Q
G
-
L
-
R
-
T
A
D
I
A
---------------------------------------
24
PsiBlast_CBE
84.72
65%
-95
- C5 -
1V5B
1
LEU3_BACCO
C:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
22
PsiBlast_CBE
84.68
65%
-94
- C5 -
1V5B
1
LEU3_BACCO
G:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
25
PsiBlast_CBE
84.32
65%
-90
- C5 -
1V5B
1
LEU3_BACCO
B:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
121
HHSearch
84.28
55%
-72
* C5 *
3R8W
5
LEU32_ARATH
A:
[41-398]
K
R
Y
T
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
------
F
R
E
M
P
I
G
G
A
A
L
D
---
L
-
V
G
V
P
L
P
E
E
T
I
S
A
A
K
-
E
-
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
----
N
N
E
K
H
-
L
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
-
V
-
A
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
R
G
I
K
T
N
-----
E
N
G
----
E
-
E
V
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-------------
R
G
K
-
L
C
S
V
D
K
A
N
V
L
E
-
A
S
I
-
L
W
R
K
R
---
V
T
A
L
A
---
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
------
L
K
-
Y
G
L
G
E
E
K
A
A
K
R
--
I
E
D
---
A
V
L
V
A
L
N
N
G
-
F
-
R
-
T
G
D
I
Y
S
-
A
G
T
K
--
L
V
G
C
K
E
-------
M
G
E
E
V
L
K
S
V
D
--------
2
PsiBlast_PDB
84.01
65%
-90
- C5 -
1V53
-
LEU3_BACCO
A:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
S
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
21
PsiBlast_CBE
83.82
65%
-89
- C5 -
1V5B
3
LEU3_BACCO
H:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
5
PsiBlast_PDB
83.62
63%
-99
- C5 -
1XAC
-
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
Q
N
P
R
E
-
L
R
P
E
K
G
-
L
L
S
I
R
K
Q
L
D
L
F
A
N
L
R
P
V
K
V
F
E
S
L
S
D
A
S
P
L
K
K
E
-
Y
-
I
D
-
N
V
D
F
V
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
4
PsiBlast_PDB
82.69
65%
-89
- C5 -
1V5B
1
LEU3_BACCO
A:
[1-334]
M
K
M
K
L
A
V
L
P
G
D
G
I
G
P
E
V
M
D
A
A
I
R
V
L
K
T
V
L
D
N
D
G
H
E
A
V
------
F
E
N
A
L
I
G
G
A
A
I
D
---
E
-
A
G
T
P
L
P
E
E
T
L
D
I
C
R
-
R
-
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
----
H
N
P
A
S
-
L
R
P
E
K
G
-
L
L
G
L
R
K
E
M
G
L
F
A
N
L
R
P
V
K
A
Y
A
T
L
L
N
A
S
P
L
K
R
E
-
R
-
V
E
-
N
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
G
R
-------
P
S
E
R
--
R
-----
G
P
G
----
E
-
N
E
V
V
D
T
L
A
Y
T
R
E
E
I
E
R
I
I
E
K
A
F
Q
L
A
Q
I
R
-------------
R
K
K
-
L
A
S
V
D
K
A
N
V
L
E
-
S
S
R
-
M
W
R
E
I
---
A
E
E
T
A
---
K
K
Y
P
D
V
E
L
S
H
M
L
V
D
S
T
A
M
Q
L
I
A
N
P
G
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
L
A
S
V
I
T
G
S
L
G
M
L
P
S
A
S
L
R
--
S
D
R
F
G
M
Y
E
P
V
H
G
S
A
P
D
I
A
G
Q
G
K
A
N
P
L
G
T
V
L
S
A
A
L
M
------
L
R
-
Y
S
F
G
L
E
K
E
A
A
A
--
I
E
K
---
A
V
D
D
V
L
Q
D
G
-
Y
-
C
-
T
G
D
L
----------------------------------------
6
PsiBlast_PDB
82.62
63%
-96
- C5 -
1XAD
-
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
Q
N
P
R
E
-
L
R
P
E
K
G
-
L
L
S
I
R
K
Q
L
D
L
F
A
N
L
R
P
V
K
V
F
E
S
L
S
D
A
S
P
L
K
K
E
-
Y
-
I
D
-
N
V
D
F
V
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
113
HHSearch
82.40
55%
-86
- C5 -
2Y3Z
7
LEU3_THET8
A:
[3-351]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
R
G
M
S
--------------
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
-
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
L
E
--
T
-
P
-
P
P
D
L
G
G
-
S
------
A
G
T
E
A
-------
F
T
A
T
V
L
R
H
L
A
A
A
A
-----
42
PsiBlast_CBE
82.12
57%
-95
- C5 -
4F7I
12
LEU3_THET8
B:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
56
PsiBlast_CBE
82.04
57%
-102
- C5 -
4WUO
16
LEU3_THET8
A:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
41
PsiBlast_CBE
81.97
57%
-94
- C5 -
4F7I
16
LEU3_THET8
C:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
55
PsiBlast_CBE
81.48
57%
-99
- C5 -
4WUO
9
LEU3_THET8
B:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
49
PsiBlast_CBE
81.45
57%
-96
- C5 -
2Y41
4
LEU3_THET8
A:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
33
PsiBlast_CBE
81.20
54%
-46
- C5 -
4XXV
3
LEU3_BURTA
B:
[10-343]
---
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
----
E
------
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
-
S
G
H
P
L
P
D
A
T
L
A
L
A
K
-
E
-
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
----
S
L
E
R
A
-
L
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
-
V
A
-
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
Q
-------
P
R
G
V
R
A
A
-----
P
D
G
PFAG
E
-
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
-------------
A
K
K
-
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
-
F
W
R
D
V
---
M
I
D
V
S
---
K
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
--
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
------
L
R
-
Y
S
L
N
R
A
E
Q
A
D
R
--
I
E
R
---
A
V
K
T
V
L
E
Q
G
-
Y
-
R
-
T
G
D
I
A
---------------------------------------
48
PsiBlast_CBE
80.69
57%
-94
- C5 -
2Y41
4
LEU3_THET8
B:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
54
PsiBlast_CBE
79.94
57%
-94
- C5 -
1HEX
1
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
52
PsiBlast_CBE
79.84
57%
-96
- C5 -
2Y3Z
7
LEU3_THET8
A:
[5-322]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
12
PsiBlast_PDB
79.47
54%
-24
- C5 -
3VKZ
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
53
PsiBlast_CBE
79.30
57%
-89
- C5 -
2ZTW
3
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
------
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
-
F
G
E
P
F
P
E
P
T
R
K
G
V
E
-
E
-
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
----
G
L
P
R
K
-
I
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
-------
P
-----
R
-----
G
M
S
----
E
-
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-------------
R
K
H
-
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
-
F
W
R
K
T
---
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
---
G
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
------
L
E
-
H
A
F
G
L
V
E
L
A
R
K
--
V
E
D
---
A
V
A
K
A
L
----------------------------------------------------
38
PsiBlast_CBE
79.14
51%
-21
- C5 -
3VMK
5
?
A:
[15-362]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
------
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
----
H
L
P
P
N
-
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
-
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
E
V
---
V
E
E
V
A
---
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
------
L
R
-
H
S
L
K
L
E
D
A
A
L
A
--
I
E
A
---
A
V
S
K
A
L
S
D
G
-
Y
-
L
-
T
C
E
L
L
P
-
A
S
E
---
R
S
Q
A
K
S
-------
T
S
Q
---------------
32
PsiBlast_CBE
79.13
54%
-24
- C5 -
3WZX
2
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
13
PsiBlast_PDB
78.99
54%
-24
- C5 -
3VL2
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
20
PsiBlast_PDB
78.77
54%
-22
- C5 -
3WZW
2
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
15
PsiBlast_PDB
78.72
54%
-23
- C5 -
3VL4
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
18
PsiBlast_PDB
78.61
54%
-26
- C5 -
3VMJ
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
17
PsiBlast_PDB
78.46
54%
-25
- C5 -
3VL7
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
120
HHSearch
78.43
50%
-4
- C5 -
3VMK
5
?
A:
[13-374]
-
S
Y
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
------
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
----
H
L
P
P
N
D
Q
P
E
R
G
A
-
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
S
-
E
K
-
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
Q
G
E
-----
G
-
E
----
N
-
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
E
V
---
V
E
E
V
A
---
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
------
L
R
-
H
S
L
K
L
E
D
A
A
L
A
--
I
E
A
---
A
V
S
K
A
L
S
D
G
-
Y
-
L
-
T
C
E
L
L
P
-
A
S
E
RSQ
A
K
S
T
S
Q
-------
M
G
D
Y
I
A
Q
A
I
A
E
G
------
19
PsiBlast_PDB
78.42
54%
-24
- C5 -
3WZV
2
?
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
14
PsiBlast_PDB
78.31
54%
-24
- C5 -
3VL3
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
16
PsiBlast_PDB
78.30
54%
-22
- C5 -
3VL6
3
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
31
PsiBlast_CBE
78.11
54%
-23
- C5 -
3WZY
2
LEU3_SHEON
A:
[15-353]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
----
K
L
P
P
N
-
E
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
-
I
S
A
R
-
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
S
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
Q
V
---
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
------
L
R
-
H
S
L
K
Q
E
E
A
A
S
A
--
I
E
R
---
A
V
T
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
----------------------------------
39
PsiBlast_CBE
78.07
50%
-17
- C5 -
3VML
3
LEU3_SHEON
A:
[15-374]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
------
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
----
H
L
P
P
N
-
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
-
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
E
V
---
V
E
E
V
A
---
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
------
L
R
-
H
S
L
K
L
E
D
A
A
L
A
--
I
E
A
---
A
V
S
K
A
L
N
S
G
-
Y
-
L
-
T
G
E
L
L
S
-
S
D
Q
---
R
H
K
A
K
T
T
V
Q
M
G
D
F
I
A
D
A
V
K
A
G
----------
37
PsiBlast_CBE
77.75
51%
-19
- C5 -
3VMK
5
?
B:
[15-362]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
------
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
-
H
G
C
P
L
P
E
A
T
L
K
G
C
E
-
A
-
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
----
H
L
P
P
N
-
D
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
-
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
-------
P
K
G
R
--
Q
-----
G
E
G
----
E
N
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-------------
R
K
K
-
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
-
L
W
R
E
V
---
V
E
E
V
A
---
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
------
L
R
-
H
S
L
K
L
E
D
A
A
L
A
--
I
E
A
---
A
V
S
K
A
L
S
D
G
-
Y
-
L
-
T
C
E
L
L
P
-
A
S
E
---
R
S
Q
A
K
S
-------
T
S
Q
---------------
124
HHSearch
67.40
35%
-11
- C5 -
3TY4
5
LYS12_SCHPO
A:
[9-364]
R
R
I
V
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
------
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
E
-
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
----
V
-----
A
G
Y
S
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
K
-----------
G
K
-
P
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
-------
E
R
M
V
Q
N
T
------
P
G
----
K
-
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
GTYSIHK
K
P
L
-
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
-
L
F
R
E
S
---
C
R
H
A
Q
S
LD
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
-
N
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
------
L
E
-
F
-
M
G
H
Q
D
A
A
A
D
--
I
Y
T
---
A
V
D
K
V
L
T
E
G
K
V
-
L
-
T
P
D
L
G
G
-
K
------
S
G
T
N
E
-------
I
T
D
A
V
L
A
N
I
---------
88
PsiBlast_CBE
66.71
34%
-45
- C5 -
4Y1P
2
?
B:
[5-335]
----
V
A
L
I
Q
G
D
G
I
G
P
E
V
V
S
K
S
K
T
I
L
A
R
L
N
E
K
F
S
L
P
I
E
------
Y
I
E
V
E
A
G
D
T
T
K
N
---
K
-
F
G
D
A
L
P
K
D
S
L
R
V
I
E
-
K
-
A
D
M
I
L
K
G
P
V
G
E
T
A
A
D
----
V
------------
V
V
K
L
R
L
M
Y
D
L
Y
A
N
L
R
P
A
K
S
L
P
G
L
E
N
K
---------
F
G
-
D
V
D
I
L
V
V
R
E
N
T
E
D
L
Y
K
G
L
----------
E
H
V
I
-----
S
D
G
----
V
-
T
V
G
I
K
V
I
--
T
R
A
A
S
T
R
I
A
Q
V
A
L
N
Q
A
L
R
R
-------------
K
K
K
-
V
V
C
V
H
K
S
N
V
M
R
I
T
D
G
-
L
F
A
E
S
---
C
R
N
V
L
---
K
--
G
K
V
E
Y
S
E
M
Y
V
D
A
A
A
A
N
L
V
R
N
P
Q
A
F
D
V
I
V
T
E
N
T
Y
G
D
I
L
S
D
E
A
G
Q
I
A
G
S
L
G
I
S
P
S
A
N
I
G
--
D
R
K
-
S
L
F
E
P
V
H
G
A
A
F
D
I
A
G
K
N
I
A
N
P
T
A
F
L
L
S
V
G
M
M
L
D
R
M
Q
E
L
S
-
G
D
I
R
Y
N
N
A
A
K
S
--
L
R
D
---
A
I
Y
S
V
Y
S
E
G
-
K
-
Y
L
T
P
D
V
G
G
-
S
----------
S
-------
T
T
D
E
M
I
S
A
I
R
S
K
------
126
HHSearch
65.12
34%
-16
- C5 -
2D1C
4
IDH_THET8
A:
[19-360]
-
R
K
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
K
----
A
P
L
A
------
Y
E
V
R
E
A
G
A
S
V
F
R
---
R
G
I
A
S
G
V
P
Q
E
T
I
E
S
I
R
-
K
-
T
R
V
V
L
K
G
P
L
E
T
P
V
G
Y
-----------
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
T
--
P
Y
A
-----
G
R
-
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
-------
E
H
M
Q
T
P
---------------
S
V
A
Q
T
L
K
L
I
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
E
G------------
R
K
K
-
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
-
T
L
K
R
A
---
F
E
Q
V
A
---
Q
E
Y
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
--
N
-
E
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
------
L
R
-
Y
-
L
E
E
F
A
T
A
D
L
--
I
E
N
---
A
L
L
Y
T
L
E
E
G
R
V
-
L
-
T
G
D
V
V
G
-
Y
D
R
---
G
A
K
T
T
E
-------
Y
T
E
A
I
I
Q
N
L
G
K
T
P
R
----
91
PsiBlast_CBE
63.34
33%
-4
- C5 -
3TY3
4
LYS12_SCHPO
A:
[13-364]
----
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
------
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
VAGY
S
S
P
----------
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
-
A
K
G
K
P
-----------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
ERMVQNT
P
G
K
R
V
A
E
A
I
R
R
I
S
E
E
----
A
-
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
K
-------------
K
P
L
-
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
-
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
------
L
E
-
F
-
M
G
H
Q
D
A
A
A
D
--
I
Y
T
---
A
V
D
K
V
L
T
E
G
-
K
V
L
-
T
P
D
L
G
G
-
K
------
S
G
T
N
E
-------
I
T
D
A
V
L
A
N
I
---------
89
PsiBlast_CBE
63.13
33%
-3
- C5 -
3TY4
7
LYS12_SCHPO
B:
[13-364]
----
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
------
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
A
GY
S
S
P
----------
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
-
A
K
G
K
P
-----------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
ERMVQNT
P
G
K
R
V
A
E
A
I
R
R
I
S
E
E
----
A
-
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
K
-------------
K
P
L
-
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
-
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
------
L
E
-
F
-
M
G
H
Q
D
A
A
A
D
--
I
Y
T
---
A
V
D
K
V
L
T
E
G
-
K
V
L
-
T
P
D
L
G
G
-
K
------
S
G
T
N
E
-------
I
T
D
A
V
L
A
N
I
---------
90
PsiBlast_CBE
62.39
33%
-3
- C5 -
3TY4
5
LYS12_SCHPO
A:
[13-364]
----
L
G
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
------
F
I
D
L
D
A
G
W
G
T
F
E
---
R
-
T
G
K
A
L
P
E
R
T
V
E
R
L
K
-
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
VAGY
S
S
P
----------
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
-
A
K
G
K
P
-----------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
ERMVQNT
P
G
K
R
V
A
E
A
I
R
R
I
S
E
E
----
A
-
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
K
-------------
K
P
L
-
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
-
L
F
R
E
S
C
R
H
A
Q
S
L
D
---
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
------
L
E
-
F
-
M
G
H
Q
D
A
A
A
D
--
I
Y
T
---
A
V
D
K
V
L
T
E
G
-
K
V
L
-
T
P
D
L
G
G
-
K
------
S
G
T
N
E
-------
I
T
D
A
V
L
A
N
I
---------
77
PsiBlast_CBE
62.09
36%
27
- C5 -
3FMX
2
TTUC_PSEPU
X:
[7-356]
---
R
I
A
A
I
P
G
D
G
I
G
L
E
V
L
P
E
G
I
R
V
L
E
A
A
A
--
L
K
H
G
L
A
------
L
E
F
D
T
F
E
W
A
S
C
D
YYL
Q
-
H
G
K
M
M
P
D
D
W
A
E
Q
L
K
-
Q
-
Y
D
A
I
Y
F
G
A
V
G
W
P
--
D
----
K
V
P
D
H
-
I
S
L
W
G
S
-
L
L
K
F
R
R
E
F
D
Q
Y
V
N
I
R
P
V
R
L
F
P
G
V
P
C
A
--
L
A
N
R
-
K
-
V
G
-
D
I
D
F
V
V
V
R
E
N
T
E
G
E
Y
S
S
L
-------
G
G
I
M
F
E
N
-----
T
E
N
----
E
-
I
V
I
Q
E
S
I
F
T
R
R
G
-
V
D
R
I
L
K
Y
A
F
D
L
A
E
K
R
-------------
E
R
K
H
V
T
S
A
T
K
S
N
G
M
A
-
I
S
M
P
Y
W
D
K
R
---
T
E
A
M
A
---
A
H
Y
P
H
V
S
W
D
K
Q
H
I
D
I
L
C
A
R
F
V
L
Q
P
E
R
F
D
V
V
V
A
S
N
L
F
G
D
I
L
S
D
L
G
P
A
C
A
G
T
I
G
I
A
P
S
A
N
L
N
PE
R
N
F
P
S
L
F
E
P
V
H
G
S
A
P
D
I
F
G
K
N
I
A
N
P
I
A
M
I
W
S
G
A
L
M
------
L
E
F
L
G
Q
G
D
E
R
Y
Q
R
A
--
H
D
D
MLN
A
I
E
R
V
I
A
D
G
-
S
-
V
-
T
P
D
M
G
G
-
T
L
S
-----------------
T
Q
Q
V
G
A
A
I
---------
84
PsiBlast_CBE
61.53
33%
30
- C5 -
2D1C
4
IDH_THET8
B:
[19-351]
-
R
K
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
K
A
P
L
A
Y
E
V
R
EAGASV
F
R
R
G
I
A
S
G
-------------
V
P
Q
E
T
I
E
S
I
R
-
K
-
T
R
V
V
L
K
G
P
L
----------
E
T
P
V
G
-
Y
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
--
T
P
Y
A
G
R
------
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
----------
E
H
M
Q
-----
T
P
S
----
V
-
A
Q
T
L
K
L
I
S
W
K
G
S
E
--
K
I
V
R
F
A
F
E
L
A
R
A
E
G------------
R
K
K
-
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
-
T
L
K
R
A
---
F
E
Q
V
A
---
Q
E
Y
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
--
N
E
-
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
------
L
R
-
Y
---
L
E
E
F
A
T
A
DL
I
E
N
---
A
L
L
Y
T
L
E
E
G
-
R
V
L
-
T
G
D
V
V
G
-
Y
D
R
---
G
A
K
T
T
E
-------
Y
T
E
A
I
-------------
85
PsiBlast_CBE
60.64
33%
30
- C5 -
2D1C
4
IDH_THET8
A:
[19-351]
-
R
K
L
I
T
V
I
P
G
D
G
I
G
P
E
C
V
E
A
T
L
K
V
L
E
A
A
K
A
P
L
A
Y
E
V
R
E
A
G
A
S
V
F
R
R
G
I
A
S
G
-------------
V
P
Q
E
T
I
E
S
I
R
-
K
-
T
R
V
V
L
K
G
P
L
----------
E
T
P
V
G
-
Y
G
E
K
S
A
-
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
P
N
V
P
--
T
P
Y
A
G
R
------
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
----------
E
H
M
Q
-----
T
P
S
----
V
-
A
Q
T
L
K
L
I
S
W
K
G
S
E
--
K
I
V
R
F
A
F
E
L
A
R
A
E
G------------
R
K
K
-
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
-
T
L
K
R
A
---
F
E
Q
V
A
---
Q
E
Y
P
D
I
E
A
V
H
I
I
V
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
T
S
G
L
I
G
G
L
G
F
A
P
S
A
N
I
G
--
N
E
-
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
V
L
L
S
A
V
M
M
------
L
R
-
Y
---
L
E
E
F
A
T
A
D
L
I
E
N
---
A
L
L
Y
T
L
E
E
G
-
R
V
L
-
T
G
D
V
V
G
-
Y
D
R
---
G
A
K
T
T
E
-------
Y
T
E
A
I
-------------