@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30860: (2016-07-21 )
MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVIPFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGDLSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDMLHPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFINEMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNTETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLMERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWKKAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP
Atome Classification :
(24 SA)
-------.........10........20..--.--.....30...--.....40........50.....----.---.---.60........70........80.....-..-----.-----90........100......---.---110.......120.....----..130..---..---...140-.........150.......160.......170.--.----.-......180.....---.-.---190-.-------........200.......210.......220.......230.......240.......250.......260.......270.....--..--280.........290.....-.-.300.-.-.....310.......320.......330.......340.......------------350-----.--.-----...--.-----------.-.-----------360-------...---......370.......380.......390..-.....400-........410.......420......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------
M
K
I
C
V
VGAG
Y
V
G
L
T
L
S
A
A
L
A
SIG--H--DMIC
T
D
K
D
V
K
--
K
I
G
Q
L
K
KGVIPFYEPG
L
S
D
A
I
L
----
R
---C---GNLS
F
S
S
E
V
K
S
S
M
E
EC
P
V
I
F
I
AVGTPPR-SD-----G-----S
A
D
T
K
A
L
Q
S
V
I
G
D
L
S
E
A
I
R
---
S
---
Y
K
T
I
I
TKSTVPPGT
N
E
N
I
----
A
K
Q
L
I
A
S
---
G
V
---
S
K
N
L
---
F
N
IVS
N
P
E
F
L
REG
N
A
L
Y
D
MLHPD
K
T
V
I
GVQ--E--E----D-
H
V
S
A
A
I
V
K
S
I
Y
K
HI---D-T---
P
---
F
-------
I
V
T
S
LA
G
A
E
L
I
K
Y
AN
N
F
F
L
A
A
K
I
S
F
I
N
E
M
A
R
I
C
E
A
Y
Q
S
D
I
S
D
I
S
R
A
IGLD
P
R
I
G
K
H
F
L
Q
A
GIGYGGSC
F
P
K
D
L
Q
A
L
Q
F
A
A
QEKN
T
E
--
T
F
--
L
--
L
R
A
V
Q
H
IND
T
Q
L
G
L
Y
I
K
-
K
-
I
Q
S
F
F
-
E
-
T
LQGK
K
A
A
V
L
G
I
SFKPN
T
D
DIR
N
S
Q
A
V
R
L
M
E
R
L
A
E
LGC
D
V
HAYD
P
------------
E
A
------
V
--
L
-----
P
E
H
--
L
-----------
R
-
Q
-----------
H
---------
V
T
Q
---
H
S
Q
A
F
D
AIEES
D
F
L
F
L
AT
E
W
S
E
F
L
A
F
D
W
K
K
A
-
A
D
IMK
G
-
R
-
L
V
ID
G
R
N
V
L
K
K
E
L
I
E
A
C
G
L
I
CTGVGRP---
21
PsiBlast_CBE
80.06
40%
-4
- C3 -
3GG2
4
?
D:
[3-424]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
N
--
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
----
R
N
V
K
A
---
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
----------
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
---
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
----
R
K
A
I
Q
E
E
---
L
D
---
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
--
S
--
D
----
R
---
A
R
E
L
I
T
S
L
Y
K
P
M
LLN
N
-
F
---
R
---
V
-------
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
--
V
--
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
-
K
-
F
S
T
Y
Y
-
K
G
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
------------
V
A
------
M
K
E
A
-----
Q
K
R
--
L
-----------
G
-
D
-----------
K
---------
V
E
Y
---
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
-
S
-
L
V
I
D
G
R
N
V
----------------------
1
PsiBlast_PDB
79.61
40%
-5
- C3 -
3GG2
4
?
A:
[3-425]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
N
--
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
----
R
N
V
K
A
---
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
-
E
D
-----
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
---
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
----
R
K
A
I
Q
E
E
---
L
D
---
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
--
S
--
D
----
R
---
A
R
E
L
I
T
S
L
Y
K
P
M
LLN
N
-
F
---
R
---
V
-------
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
--
V
--
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
-
K
-
F
S
T
Y
Y
-
K
G
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
------------
V
A
------
M
K
E
A
-----
Q
K
R
--
L
-----------
G
-
D
-----------
K
---------
V
E
Y
---
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
-
S
-
L
V
I
D
G
R
N
V
----------------------
22
PsiBlast_CBE
77.87
40%
-10
- C3 -
3GG2
2
?
C:
[3-424]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
N
--
K
I
E
Q
L
N
S
----
I
Y
E
P
G
L
E
K
M
I
A
----
R
N
V
K
A
---
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
---
D
-----
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
---
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
----
R
K
A
I
Q
E
E
---
L
D
---
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
--
S
--
D
----
R
---
A
R
E
L
I
T
S
L
Y
K
P
M
---------
R
---
V
-------
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
--
V
--
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
-
K
-
F
S
T
Y
Y
-
K
G
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
------------
V
A
------
M
K
E
A
-----
Q
K
R
--
L
-----------
G
-
D
-----------
K
---------
V
E
Y
---
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
-
S
-
L
V
I
D
G
R
N
V
----------------------
105
HHSearch
77.76
40%
-6
- C3 -
3GG2
4
?
A:
[3-436]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
N
--
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
----
R
N
V
K
A
---
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
-
E
D
-----
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
---
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
----
R
K
A
I
Q
E
E
L
D
K
R
E
---
V
L
I
D
---
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
--
S
--
D
----
R
---
A
R
E
L
I
T
S
L
Y
K
P
M
---
L
-
L
---
N
NFR
V
-------
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
--
V
--
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
-
S
T
Y
Y
K
-
G
-
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
------------
V
A
------
M
--
K
E
----
A
Q
K
--
R
L----------
G
-
D
-----------
K
---------
V
E
Y
---
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
-
S
-
L
V
I
D
G
R
N
V
Y
E
L
P
------
F
T
L
L
N
I
G
-----
27
PsiBlast_CBE
76.93
38%
-3
- C3 -
2Y0C
11
?
C:
[9-460]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
------
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
28
PsiBlast_CBE
76.49
38%
-8
- C3 -
2Y0C
11
?
B:
[9-460]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
------------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
----------
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
3
PsiBlast_PDB
76.42
38%
-2
- C3 -
2Y0E
10
?
A:
[9-460]
-------
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
24
PsiBlast_CBE
75.93
38%
-6
- C3 -
2Y0E
13
?
C:
[9-460]
-------
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
-----------
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
31
PsiBlast_CBE
75.78
38%
-5
- C3 -
2Y0D
3
?
B:
[9-460]
-------
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
----------------
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
-
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
23
PsiBlast_CBE
75.12
38%
-4
- C3 -
2Y0E
7
?
D:
[9-460]
-------
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
-----------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
123
Fugue
75.05
33%
3
- C3 -
2O3J
4
UGDH_CAEEL
A:
[3-471]
DQVFGKV
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
--
P
H
I
T
V
T
V
V
D
M
N
T
A
--
K
I
A
E
W
N
S
D
K
L
P
I
Y
E
P
G
L
D
E
I
V
F
----
A
---
A
RG-
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
-
M
Y
-----
G
RGKGM
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
---
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
----
G
C
I
L
R
E
A
--------
Q
K
L
K
---
F
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
SS
P
--
E
----
G
-
L
Q
A
V
A
E
L
V
R
I
Y
E
N
W
VP-
R
-
N
---
R
---
I
-------
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
I
G
S
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
E
S
L
N
L
P
--
Q
V
--
A
D
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
-
K
-
I
I
A
E
L
F
N
-
T
V
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
KVQ
K
S
Q
M
L
N
D
L
A
S
V
------
T
--
S
-----
A
Q
D
--
V
-----------
E
-
R
-----------
L
---------
I
T
V
---
E
S
D
P
Y
A
A
A
R
G
A
H
A
I
V
V
L
T
E
W
D
E
F
V
E
L
N
Y
S
Q
I
-
H
N
D
M
Q
H
-
P
A
A
I
F
D
G
R
L
I
L
D
Q
K
A
L
R
E
I
G
F
R
T
F
A
I
G
T
S
PDQ
4
PsiBlast_PDB
74.95
38%
2
- C3 -
2Y0C
11
?
A:
[9-460]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
25
PsiBlast_CBE
74.77
38%
-4
- C3 -
2Y0E
9
?
B:
[9-460]
-------
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
----------------
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
----------
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
26
PsiBlast_CBE
74.55
38%
-2
- C3 -
2Y0C
9
?
D:
[9-460]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
-----------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
30
PsiBlast_CBE
74.52
38%
-0
- C3 -
2Y0D
6
?
C:
[9-460]
-------
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
--------------
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
29
PsiBlast_CBE
74.43
38%
-4
- C3 -
2Y0D
4
?
D:
[9-460]
-------
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
NRS
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
---------
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
RAAV
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHERT
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
QEEARR
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
PSWLERLSF
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
99
HHSearch
74.38
38%
-5
- C3 -
2Y0C
11
?
A:
[9-460]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
----
R
A
A
V
A
E
E
---
L
A
K
R
G
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
--
D
--
D
V
P
G
E
R
---
A
R
E
L
M
K
K
L
Y
A
P
F
---
N
-
R
NHE
R
---
T
-------
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
-
V
A
R
F
G
-
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
------
Q
--
E
E
----
A
R
R
--
V
I
A
L
D
L
A
DH
P
S
W
L
-
E
-----------
R
---------
L
S
F
---
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
5
PsiBlast_PDB
74.30
38%
-3
- C3 -
2Y0D
7
?
A:
[9-460]
-------
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
A
--
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
----
R
N
R
S
A
---
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
-
E
------------
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
---
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---
G
----
G
D
Q
M
---
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
------
D
----
D
-
D
V
P
G
E
R
A
R
E
L
M
K
K
L
---
Y
-
A
---
P
---
F
NRNHER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
--
I
--
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
-
K
-
I
V
A
R
F
G
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
------------
V
A
Q
E
E
A
R
R
V
--
I
-----
A
L
D
--
L
-----------
A
-
D
-----------
H
P
S
W
L
E
R
L
S
F
V
D
D
---
E
A
Q
---
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
---
102
HHSearch
74.16
32%
-10
- C3 -
2O3J
4
UGDH_CAEEL
A:
[10-468]
-------
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
PH
I
--
T
V
T
V
V
D
M
N
T
A
--
K
I
A
E
W
N
S
D
K
L
P
I
Y
E
P
G
L
D
E
I
V
F
----
A
A
R-
G
---
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
-
M
Y
GRGKG
M
-----
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
---
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
----
G
C
I
L
R
E
A
---
Q
K
-----
L
K
---
F
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
--
S
--
S
P
---
E
G
L
Q
A
V
A
E
L
V
R
I
Y
E
N
W
---
V
P
R
N--
R
---
I
-------
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
I
G
S
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
E
S
L
N
L
P
Q
V
A
D
--
Y
--
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
-
I
A
E
L
F
-
N
-
T
V
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
------------
K
V
------
Q
--
K
S
----
Q
M
L
--
N
-----------
D
-
L
A
S
V
TS
A
Q
D
V
E
R
L
---------
I
T
V
---
E
S
D
P
Y
A
A
A
R
G
A
H
A
I
V
V
L
T
E
W
D
E
F
V
E
L
N
Y
S
Q
I
-
H
N
D
M
Q
H
P
A
-
A
I
F
D
G
R
L
I
L
D
Q
K
A
L
R
E
I
G
F
R
T
F
A
I
G
T
S
---
87
PsiBlast_CBE
73.51
31%
5
- C3 -
3ITK
4
UGDH_HUMAN
B:
[7-446]
--------
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
--
P
--
E
I
R
V
T
V
V
D
V
N
ES
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
----
S
---
C
RG-
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
-
T
Y
-----
G
MGKGR
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
---
Y
K
I
V
T
E
K
S
A
V
P
V
R
A
A
E
S
I
-----
R
R
I
F
D
A
---
N
T
---
K
P
N
L
N--
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
--
E
TP
E
----
G
-
Q
R
A
V
Q
A
L
C
A
V
Y
E
H
W
VP-
R
-
E
---
K
---
I
-------
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
--
E
V
AR
Y
--
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
-
R
I
I
D
S
L
F
-
N
-
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
KVPR--------
E
Q
------
I
--
V
VDLSH
D
D
Q
--
V
-----------
S
-
R
-----------
L
---------
V
T
I
---
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
-
A
-
F
I
F
D
G
R
R
V
L
---------------------
104
HHSearch
72.92
37%
-6
- C3 -
3VTF
2
?
A:
[22-443]
-------
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
--
H
--
R
V
V
G
Y
D
V
N
P
S
--
I
V
E
R
L
R
A
G
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
----
R
A
L
S
S
---
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
-
P
D
-----
G
-----
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
---
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
----
V
A
R
A
V
A
E
---
E
A
---
G
G
V
K
---
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
--
D
--
E
----
R
---
A
A
S
F
L
L
D
V
Y
K
A
V
---
D
-
A
---
P
---
K
-------
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
G
L
E
--
M
A
--
I
--
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
-
E
E
R
L
G
---
G
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
------------
M
A
------
M
--
E
K
----
A
R
A
--
V
-----------
L
G
D
-----------
S
---------
V
T
Y
---
V
E
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
Y
--------
R
G
-
K
-
V
V
V
D
G
R
Y
V
K
K
A
R
----
E
A
K
I
Y
E
G
V
A
W
----
6
PsiBlast_PDB
72.53
35%
-8
- C3 -
3VTF
2
?
A:
[24-431]
---------
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
--
H
--
R
V
V
G
Y
D
V
N
P
S
--
I
V
E
R
L
R
A
G
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
----
R
---
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
-
P
D
-----
G
-----
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
---
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
----
V
A
R
A
V
A
E
---
E
A
---
G
G
V
K
---
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
--
D
--
E
----
R
---
A
A
S
F
L
L
D
V
Y
K
A
V
---
D
-
A
---
P
---
K
-------
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
G
L
E
--
M
A
--
I
--
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
-
L
-
L
E
E
R
L
-
G
-
G
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
------------
M
A
------
M
--
E
-----
K
A
R
A
V
L
-----------
G
-
D
-----------
S
---------
V
T
Y
---
V
E
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
Y
--------
R
G
-
K
-
V
V
V
D
G
R
Y
V
K
K
--------------------
100
HHSearch
70.02
39%
2
- C3 -
4A7P
1
?
A:
[9-443]
-------
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
--
H
--
E
V
V
C
V
D
K
D
A
R
--
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
----
S
N
V
K
A
---
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
G
D
-----
G
-----
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
---
P
S
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
----
E
R
I
I
A
E
V
---
A
----
P
N
S
G
---
A
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
--
D
--
E
----
F
---
A
R
Q
V
M
R
E
I
Y
R
P
L
---
S
-----
P
---
V
-------
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
E
T
P
--
L
R
--
I
--
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
-
I
K
A
M
G
-
G
-
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
------------
E
G
------
V
--
E
Q
----
A
S
K
--
M
-----------
L
-
T
-----------
D
---------
V
E
F
---
V
E
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
-
K
N
S
L
K
S
-
P
-
V
L
V
D
L
R
N
I
Y
P
P
A
E
L
E
R
A
G
L
Q
Y
T
G
V
G
K
P
---
2
PsiBlast_PDB
69.57
38%
22
- C3 -
4A7P
1
?
A:
[9-443]
-------
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
--
H
--
E
V
V
C
V
D
K
D
A
R
--
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
-
D
A
L
V
A
S
N
V
K
---
A
---
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
G
D
-----
G
-----
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
---
P
S
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
-----
E
R
I
I
A
E
---
V
A
---
P
N
S
G
---
A
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
------
E
----
D
-
E
F
A
R
Q
V
M
R
E
I
Y
R
P
L
---
S
-----
P
---
V
-------
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
E
T
P
--
L
R
--
I
--
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
-
K
V
I
K
A
M
G
-
G
-
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
------------
E
G
------
V
---------
E
Q
--
A
-----------
S
-
K
-----------
M
---------
L
T
D
V
E
F
V
E
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
-
K
N
S
L
K
S
-
P
-
V
L
V
D
L
R
N
I
Y
P
P
A
E
L
E
R
A
G
L
Q
Y
T
G
V
G
K
P
---