@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32100: (2016-07-23 )
MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYHYETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQYDYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLTIVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYAVHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAGFENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNLGRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIGGLGLTLKKGKFKFF
Atome Classification :
(20 SA)
------.........10........20........30........40.......-.50.........60........70--.-----.......80........-90.....--.---------------------.----------------------.100.......110.......120-.......130.......140......---.150--.......---.160.......-------------------------170.......180-------..-...-..-.190.......200.......-210.......220.......230.......240----.....----..----.250---........260.......270----..-----....--.280..-......290.......300.......310........320.......330....--------------------...--340----------------.-........350-----------........-360.....-.----.370.......380.......390....-...400....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MALNK
P
K
I
V
I
L
GAGYG
G
L
M
T
V
T
R
L
T
K
YVGPNDA
D
I
T
L
V
NKH
N
Y
H
Y
E
T
T
-
W
M
-
H
EASAGTL
H
H
D
R
C
R
Y
Q
I
K
D
V
I
--
N
-----
Q
S
R
V
N
F
V
Q
D
T
V
K
A
IKID-E
K
K
V
V
L
A--N---------------------G----------------------
E
L
Q
Y
D
Y
L
V
I
GLGAV
P
E
T
F
G
I
K
G
L
K
-
E
YAFPIANI
N
T
S
R
L
L
R
E
H
I
E
L
Q
F
A
TY---NTE---AEKRP
D
R
---
L
T
I
V
VGGAG
F
T
-------------------------
G
I
E
F
L
G
E
L
A
A
R
V
--------
P
E
-
L
C
K
-
E
Y-DV
D
R
S
L
V
R
I
I
CVEAAPTVLPG-F
D
P
E
L
V
D
Y
A
V
H
Y
L
E
ENG
V
E
F
K
I
G
T
A
V
Q
ECTPE-----GVRVG----KK----DE
E
----
P
E
Q
I
KSQ
T
V
V
W
A
AGVRGHP
I
V
----
E
E-----AGFE--NM-R
G
R
-
V
K
VNPDLRAPGHD
N
V
F
I
LGDS
S
L
FMNE-DTERPYPP
T
A
Q
I
A
M
Q
QG
I
T
V
A
K
N
L
G
R
--------------------
L
IK--G------------------G-
E
L
E
E
FKPD
I
K
------------
G
T
V
A
SLGE-HN
A
V
G
V
V
Y-G----RKLKGT
P
A
S
F
M
K
K
V
IDNR
S
L
F
M
IGGL
G
L
-
T
LKKGKFKFF--------------
1
PsiBlast_PDB
99.25
62%
-138
- C2 -
4NWZ
1
?
A:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
-
E
L
-
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
--
D
-----
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
-
Q
Q
K
V
T
L
Q
--
N
---------------------
G
----------------------
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
---
A
A
E
---
P
E
-
R
T
D
Y
---
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
--------
P
E
-
L
C
A
-
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----
G
V
V
I
-----
E
V
----
D
G
E
----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
----
E
K
-----
S
G
F
E
--
T
M
-
R
G
R
-
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
--------------------
L
I
R
--
G
------------------
G
-
S
M
T
P
F
K
P
H
I
R
------------
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
-
G
----
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
-
V
L
K
K
G
-------------------
22
PsiBlast_CBE
98.91
62%
-136
- C2 -
4NWZ
1
?
B:
[3-397]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
-
E
L
-
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
--
D
-----
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
-
Q
Q
K
V
T
L
Q
--
N
---------------------
G
----------------------
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
---
A
A
E
---
P
E
-
R
T
D
Y
---
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
--------
P
E
-
L
C
A
-
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----
G
V
V
I
-----
E
V
----
D
G
E
----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
----
E
K
-----
S
G
F
E
--
T
M
-
R
G
R
-
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
--------------------
L
I
R
--
G
------------------
G
-
S
M
T
P
F
K
P
H
I
R
------------
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
-
G
----
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
-
V
L
K
K
G
-------------------
21
PsiBlast_CBE
98.65
62%
-138
- C2 -
4NWZ
1
?
C:
[3-396]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
-
E
L
-
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
--
D
-----
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
-
Q
Q
K
V
T
L
Q
--
N
---------------------
G
----------------------
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
---
A
A
E
---
P
E
-
R
T
D
Y
---
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
--------
P
E
-
L
C
A
-
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----
G
V
V
I
-----
E
V
----
D
G
E
----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
----
E
K
-----
S
G
F
E
--
T
M
-
R
G
R
-
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
--------------------
L
I
R
--
G
------------------
G
-
S
M
T
P
F
K
P
H
I
R
------------
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
-
G
----
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
-
V
L
K
K
--------------------
28
HHSearch
96.45
62%
-120
- C2 -
4NWZ
1
?
A:
[3-396]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
T
T
-
E
L
-
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
L
I
--
D
-----
E
K
K
I
K
F
V
K
D
T
V
V
A
I
D
R
E
-
Q
Q
K
V
T
L
Q
--
N
---------------------
G
----------------------
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
-
E
H
A
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
---
A
A
----
E
P
E
R
T
D
Y
---
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
--------
P
E
-
L
C
A
-
E
Y
-
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
-
F
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----
G
V
V
I
E
----
V
-----
D
G
E
----
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
----
E
K
-----
S
G
F
E
--
T
M
-
R
G
R
-
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
--------------------
L
I
R
--
G
------------------
G
-
S
M
T
P
F
K
P
H
I
R
------------
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
-
G
----
R
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
S
L
-
V
L
K
K
--------------------
24
PsiBlast_CBE
87.96
52%
-90
- C2 -
4XDB
4
Y878_STAA8
C:
[11-408]
----------
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
-
W
L
-
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
--
K
-----
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
-
A
K
K
V
E
T
N
--
Q
---------------------
G
----------------------
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
-
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
---
A
A
S
---
K
E
K
D
D
N
D
---
L
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
--------
P
E
-
L
C
S
-
K
Y
-
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
-
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
-----
G
F
V
V
-----
E
V
----
D
G
E
----
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
----
E
E
-----
S
-
F
E
--
G
V
K
R
G
R
-
I
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
-
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
--------------------
I
L
N
--
G
------------------
E
-
S
T
E
E
F
E
Y
V
D
R
------------
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
-
G
----
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
-
A
F
K
K
G
K
F
-----------------
25
PsiBlast_CBE
87.48
52%
-89
- C2 -
4XDB
3
Y878_STAA8
B:
[10-408]
---------
D
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
-
W
L
-
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
--
K
-----
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
-
A
K
K
V
E
T
N
--
Q
---------------------
G
----------------------
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
-
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
---
A
A
S
---
K
E
K
D
D
N
D
---
L
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
--------
P
E
-
L
C
S
-
K
Y
-
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
-
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
-----
G
F
V
V
-----
E
V
----
D
G
E
----
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
----
E
E
-----
S
-
F
E
--
G
V
K
R
G
R
-
I
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
-
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
--------------------
I
L
N
--
G
------------------
E
-
S
T
E
E
F
E
Y
V
D
R
------------
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
-
G
----
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
-
A
F
K
K
G
K
F
-----------------
2
PsiBlast_PDB
87.36
52%
-91
- C2 -
4XDB
1
Y878_STAA8
A:
[9-408]
--------
Q
D
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
-
W
L
-
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
--
K
-----
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
-
A
K
K
V
E
T
N
--
Q
---------------------
G
----------------------
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
-
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
---
A
A
S
---
K
E
K
D
D
N
D
---
L
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
--------
P
E
-
L
C
S
-
K
Y
-
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
-
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
-----
G
F
V
V
-----
E
V
----
D
G
E
----
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
----
E
E
-----
S
-
F
E
--
G
V
K
R
G
R
-
I
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
-
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
--------------------
I
L
N
--
G
------------------
E
-
S
T
E
E
F
E
Y
V
D
R
------------
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
-
G
----
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
-
A
F
K
K
G
K
F
-----------------
26
HHSearch
87.18
53%
-89
- C2 -
4XDB
1
Y878_STAA8
A:
[9-407]
--------
Q
D
R
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
-
W
L
-
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
--
K
-----
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
-
A
K
K
V
E
T
N
--
Q
---------------------
G
----------------------
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
-
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
---
A
A
S
---
K
E
K
D
D
N
D
---
L
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
--------
P
E
-
L
C
S
-
K
Y
-
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
-
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
-----
G
F
V
V
E
----
V
-----
D
G
E
----
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
----
E
E
-----
S
-
F
E
G-
V
K
-
R
G
R
-
I
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
-
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
--------------------
I
L
N
--
G
------------------
E
-
S
T
E
E
F
E
Y
V
D
R
------------
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
-
G
----
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
-
A
F
K
K
G
K
------------------
23
PsiBlast_CBE
87.13
52%
-89
- C2 -
4XDB
2
Y878_STAA8
D:
[12-408]
-----------
K
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
A
T
-
W
L
-
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
V
L
--
K
-----
K
D
K
V
N
F
V
Q
A
E
V
T
K
I
D
R
D
-
A
K
K
V
E
T
N
--
Q
---------------------
G
----------------------
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
-
D
H
A
F
Q
I
E
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
---
A
A
S
---
K
E
K
D
D
N
D
---
L
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
R
I
--------
P
E
-
L
C
S
-
K
Y
-
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
-
F
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
V
A
C
N
E
K
-----
G
F
V
V
-----
E
V
----
D
G
E
----
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
----
E
E
-----
S
-
F
E
--
G
V
K
R
G
R
-
I
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
-
G
E
E
R
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
--------------------
I
L
N
--
G
------------------
E
-
S
T
E
E
F
E
Y
V
D
R
------------
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
-
G
----
K
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
L
-
A
F
K
K
G
K
F
-----------------
9
PsiBlast_PDB
60.43
25%
-16
- C2 -
4G74
8
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQDK
I
D
L
-------
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
4
PsiBlast_PDB
59.80
25%
-13
- C2 -
4GAP
2
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
--------
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
6
PsiBlast_PDB
59.25
25%
-13
- C2 -
4G6G
6
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
--------
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
3
PsiBlast_PDB
58.54
25%
-13
- C2 -
4G9K
1
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
--------
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
7
PsiBlast_PDB
58.02
25%
-12
- C2 -
4G6H
5
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQKNLSSRKDK
I
D
L
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
8
PsiBlast_PDB
57.81
25%
-14
- C2 -
4G73
8
NDI1_YEAST
A:
[41-448]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
N
L
S
SRKDK
I
D
L
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
5
PsiBlast_PDB
57.62
25%
-13
- C2 -
4GAV
2
NDI1_YEAST
A:
[10-417]
---------
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
----
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
---
I
E
P
I
V
--
N
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
---
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DLRKFL
P
A
-
L
A
E
-
E
--------
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
----
H
E
D
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-----
I
P
E
Q
--
N
S
-
S
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
--------
L
F
E
--
E
------------------
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
------------------------------------------------------------
27
HHSearch
53.84
26%
-12
- C2 -
4G6H
5
NDI1_YEAST
A:
[39-494]
-------
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
----
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
K
-----
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
-
R
N
T
V
T
I
K
--
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
A
----------------------
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
PKG
D
P
E
R
R
R
L
---
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
--------
H
Q
-
D
L
R
K
F
L
P
A
L
A
-
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
T
KHE
D
G
----
K
I
T
----
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
----
T
D
L
F
K
K
-
I
P
E
Q
N-
S
S
-
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
G
--------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
--------------------
M
A
Q
I
P
N
FQKNLSSRKDK
I
D
L
L
F
E
E
N
-
N
F
K
P
F
K
Y
N
D
L
------------
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
S
G
KRTF
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
--------------
32
HHSearch
51.64
19%
-30
- C2 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
K
A
D
V
K
V
I
N
K
S
R
F
S
Y
F
R
P
-
A
L
-
P
H
V
A
I
G
V
R
D
V
D
E
L
K
V
D
L
S
E
A
L
--
P
-----
E
K
G
I
Q
F
Q
E
G
T
V
E
K
I
D
A
K
-
S
S
M
V
Y
Y
T
K
P
D
---------------------
G
S
M
A
-------------------
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
L
V
K
G
W
D
-
K
Y
G
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
------------------
Q
G
---
G
N
I
A
I
-
G
S
G
P
F
YQGHNPKPKVPENF
V
P
N
A
DSACE
G
P
V
F
E
M
S
L
M
L
H
G
Y
F
--------
K
K
-
K
------
G
M
L
-
D
K
V
H
V
T
V
F
S
P
G
E
-
Y
L
S
D
-
L
S
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
K
E
I
R
E
H
-----
E
I
V
D
E
----
K
------------
G
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
T
G
N
P
A
L
----
K
N
-----
S
T
P
D
LV
D
D
-
G
G
F
-
I
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
S
M
T
--------
V
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
N
--------------------
R
L
G
--
V
------------------
P
T
K
V
D
K
Y
Y
P
T
I
V
------------
C
V
A
-
D
N
P
Y
E-------------------------------------------------------------------
50
Fugue
48.34
26%
33
- C2 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
----
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
T
P
-
L
L
-
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
--
L
-----
K
K
K
G
N
V
T
Y
Y
E
A
E
A
T
S
I
N
P
D
R
N
T
V
T
I
--
K
---------------------
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
-
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
---
D
P
E
R
R
R
L
---
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
--------
H
Q
D
L
R
K
-
F
L
-
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
-
F
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----
Q
L
L
A
K
----
T
K
H
EDG
K
I
T
----
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
----
T
D
L
F
K
K
I
P
E
Q
N
--
S
S
-
K
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
--------
A
F
A
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
--------------------
M
A
Q
--
I
------------------
P
-
N
F
Q
K
I
D
L
L
F
E
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
-
S
----
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
-
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL
46
HHSearch
47.90
23%
-16
- C2 -
3FG2
2
?
P:
[1-310]
----------
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
--
P
G
R
I
A
L
I
N
D
E
K
H
L
P
Y
Q
R
P
P
L
S
K
A
Y
L
K
S
G
G
D
P
N
S
L
M
F
R
P
E
K
F
F
--
Q
-----
D
Q
A
I
E
L
I
S
D
R
M
V
S
I
D
R
E
-
G
R
K
L
L
L
A
--
S
---------------------
G
T---------------------
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
D
V
P
N
A
S
L
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
--------------------
P
D
K
---
K
H
V
V
V
I
G
A
G
F
I
-------------------------
G
L
E
F
A
A
T
A
R
A
K
G
------------------------
L
E
V
D
V
V
E
L
A
P
R
V
M
A
R
V
V
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
R
A
T
E
I
A
A
E
GDRVT
G
V
V
L
S
----
D
------------
G
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
----
A
A
A----
A
G
L
P
--
T
--
A
A
G
-
I
I
V
D
Q
Q
L
L
T
-
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
R
F
G
E
T
M
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
--------------------
D
---------------------------------------------------------------------------------------------------------------------------