@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35060: (2016-07-29 )
MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFISRYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYTRGPVSLLVAFDGA
Atome Classification :
(20 SA)
.........10....--....20.....-.-.-.30..-----...----------.---..40........50........60---..--..--.---..------.---70........------80...-----.....90........100.......110.......120...-.-....130.......140.......150.......160.......170.......180.........190.......200.......210.......220.......230.......240.......250........260.......270......--.280-.......290.......300.......310.......320.......330.......340.....-..350.......360.......370.....------..---380--.--...-.-..390.......400...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQ
S
I
K
L
F
S
V
L
S
D
Q
F--QNN
P
Y
A
Y
F
S
Q
L-R-E-EDP
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
LQHPDIF
T
T
---
K
S
--
L
V
--
E
---RA------
E
---
P
V
MRGP
V
L
A
Q
------MHGKE-----HSAK
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
QN
A
E
N
L
L
A
P
Y
L
E
-RG
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
LGLD
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
ISQSPE
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
ERRVNP
G
S
D
L
I
S
I
L
CTSEYEGMALS
D
K
D
I
L
A
L
I
L
N
V
L
L
AATEPA
D
K
T
L
A
L
M
I
Y
H
L
L-N
N
P
E
Q
M
N
D
V
L
ADRSL
V
P
R
A
I
A
E
T
LRYKP--
P
V
Q
L
-
I
P
R
QLSQDTVVG
G
M
E
IKK
D
T
I
V
F
C
M
IGAANRDPEAFEQPD
V
F
N
I
H
R
E
DLGI
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
A
A
FAK
N
E
I
E
I
V
A
N
I
V
L
D
K
M
RNI------RL---EED--F--CYA-E-SGLYTRG
P
V
S
L
L
V
A
FDGA
1
PsiBlast_PDB
98.00
99%
-138
- C2 -
3NC3
6
CYPX_BACSU
A:
[41-439]
----
I
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
------------------------
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
------
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
--
F
--
C
Y
A
-
E
-
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
--
2
PsiBlast_PDB
97.99
99%
-141
- C2 -
3NC5
4
CYPX_BACSU
A:
[42-439]
-----
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
-----------------------
S
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
S
E
Y
--
M
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
--
F
--
C
Y
A
-
E
-
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
--
40
HHSearch
97.91
99%
-134
- C2 -
3NC3
6
CYPX_BACSU
A:
[41-439]
----
I
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
------------------------
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
------
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
-----
F
C
Y
-
A
E
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
--
23
PsiBlast_CBE
96.35
99%
-132
- C2 -
3NC3
5
CYPX_BACSU
B:
[41-440]
----
I
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
G
P
---------------------
S
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
S
-----
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
--
F
--
C
Y
A
-
E
-
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
G
-
22
PsiBlast_CBE
95.81
99%
-131
- C2 -
3NC6
2
CYPX_BACSU
B:
[40-440]
---
S
I
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
-----------------------
S
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
S
E
Y
E
G
M
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
--
F
--
C
Y
A
-
E
-
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
G
-
21
PsiBlast_CBE
94.95
99%
-134
- C2 -
3NC7
3
CYPX_BACSU
B:
[42-440]
-----
K
L
F
S
V
L
S
D
Q
F
--
Q
N
N
P
Y
A
Y
F
S
Q
L
-
R
-
E
-
E
D
P
V
H
-----
Y
E
E
----------
S
---
I
D
S
Y
F
I
S
R
Y
H
D
V
R
Y
I
L
Q
H
P
D
I
F
T
T
---
K
S
--
L
V
--
E
---
R
A
------
E
---
P
V
M
R
G
----------------------
S
A
K
R
R
I
V
V
R
S
F
I
G
D
A
L
D
H
L
S
P
L
I
K
Q
N
A
E
N
L
L
A
P
Y
L
E
-
R
G
K
-
S
-
D
L
V
N
D
F
G
K
T
F
A
V
C
V
T
M
D
M
L
G
L
D
K
R
D
H
E
K
I
S
E
W
H
S
G
V
A
D
F
I
T
S
I
S
Q
S
P
E
A
R
A
H
S
L
W
--
C
S
E
Q
L
S
Q
Y
L
M
P
V
I
K
E
R
R
V
N
P
G
S
D
L
I
S
I
L
C
T
S
E
----
A
L
S
D
K
D
I
L
A
L
I
L
N
V
L
L
A
A
T
E
P
A
D
K
T
L
A
L
M
I
Y
H
L
L
-
N
N
P
E
Q
M
N
D
V
L
A
D
R
S
L
V
P
R
A
I
A
E
T
L
R
Y
K
P
--
P
V
Q
L
-
I
P
R
Q
L
S
Q
D
T
V
V
G
G
M
E
I
K
K
D
T
I
V
F
C
M
I
G
A
A
N
R
D
P
E
A
F
E
Q
P
D
V
F
N
I
H
R
E
D
L
G
I
K
S
A
F
S
G
A
A
R
H
L
A
F
G
-
S
G
I
H
N
C
V
G
T
A
F
A
K
N
E
I
E
I
V
A
N
I
V
L
D
K
M
R
N
I
------
R
L
---
E
E
D
--
F
--
C
Y
A
-
E
-
S
G
L
Y
T
R
G
P
V
S
L
L
V
A
F
D
G
-
51
HHSearch
55.63
25%
-23
- C2 -
2XKR
2
CP142_MYCTU
A:
[9-393]
--------
L
A
D
G
N
F
Y
--
A
S
R
E
A
R
A
A
Y
R
W
M
R
-
A
-
N
Q
P
V
F
-----
R
D
R
----------
N
----
G
L
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
L
F
S
N
---
A
G
--
G
I
--
R
---
P
-----------
D
Q
P
A
L
P
M
M
I
D
------
M
D
D
P
A
-----
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
L
C
D
T
L
I
D
A
V
C
E
-
R
G
E
-
C
-
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
E
Q
R
D
M
F
L
R
W
S
D
D
L
V
T
F
L
S
S
H
V
S
-
Q
E
D
F
Q
I
T
M
D
--
A
F
A
A
Y
N
D
F
T
R
A
T
I
A
A
R
R
A
D
P
T
D
D
L
V
S
V
L
V
S
S
E
V
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
-
R
N
R
D
Q
W
D
L
L
Q
R
D
P
S
L
L
P
G
A
I
E
E
M
L
R
W
T
A
--
P
V
K
N
-
M
C
R
V
L
T
A
D
T
E
F
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
----------
N
S
H
L
A
F
G
-
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
L
------
R
L
---
V
A
D
--
D
SV
L
P
L
-
R
-
P
A
N
F
V
S
G
L
E
S
M
P
V
V
F
T
P
-
37
HHSearch
54.29
25%
-14
- C2 -
3BUJ
1
?
A:
[3-395]
------
A
F
D
P
T
D
A
D
V
--
R
R
D
P
Y
P
S
Y
H
W
L
-
L
-
R
-
H
D
P
V
H
-----
R
G
A
--------------
H
R
V
W
Y
V
S
R
F
A
D
V
R
A
V
L
G
D
E
R
-
F
A
R
---
T
G
--
I
R
R
F
W
---
T
D
L
V
GPG
L
L
---
A
E
I
V
G
D
I
I
L
F
------
Q
D
E
P
D
-----
H
G
R
L
R
G
V
V
G
P
A
F
S
P
S
A
L
R
R
L
E
P
V
I
A
G
T
V
D
D
L
L
R
P
A
L
A
-
R
G
A
-
M
-
D
V
V
D
E
L
A
Y
P
L
A
L
R
A
V
L
G
L
L
G
L
P
A
A
D
W
G
A
V
G
R
W
S
R
D
V
G
R
T
L
D
R
G
A
S
-
A
E
D
M
R
R
G
H
A
--
A
I
A
E
F
A
D
Y
V
E
R
A
L
A
R
R
R
R
E
G
G
E
D
L
L
A
L
M
L
D
A
H
D
-
R
G
L
M
S
R
N
E
I
V
S
T
V
V
T
F
I
F
T
G
H
E
T
V
A
S
Q
V
G
N
A
V
L
S
L
L
-
A
H
P
D
Q
L
D
L
L
R
R
R
P
D
L
L
A
Q
A
V
E
E
C
L
R
Y
D
P
--
S
V
Q
S
-
N
T
R
Q
L
D
V
D
V
E
L
R
G
R
R
L
R
R
D
D
V
V
V
V
L
A
G
A
A
N
R
D
P
R
R
Y
D
R
P
D
D
F
D
I
E
R
D
P
----------
V
P
S
M
S
F
G
-
A
G
M
R
Y
C
L
G
S
Y
L
A
R
T
Q
L
R
A
A
V
A
A
L
A
R
L
P
-
G
L
------
R
L
---
G
C
A
--
S
DA
L
A
Y
-
Q
-
P
R
T
M
F
R
G
L
A
S
L
P
I
A
F
T
P
-
12
PsiBlast_PDB
52.82
26%
1
- C2 -
4YT3
3
?
A:
[8-397]
--
K
E
I
T
R
F
K
T
R
T
E
E
F
----
S
P
Y
A
W
C
K
R
M
-
L
-
E
-
N
D
P
V
S
-----
Y
H
E
----------
G
---
T
D
T
W
N
V
F
K
Y
E
D
V
K
R
V
L
S
D
Y
K
H
F
S
S
VRK------------------------------
V
P
E
K
------
I
Q
I
T
E
SDP
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
I
A
D
E
L
I
G
Q
M
D
G
--
T
E
-
I
-
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
K
D
R
L
L
F
K
K
W
---
V
D
T
L
F
L
P
F
----
Q
E
E
V
D
K
L
K
Q
V
A
A
K
E
Y
Y
Q
Y
L
Y
P
I
V
V
Q
K
R
L
N
P
A
D
D
I
I
S
D
L
L
K
S
E
V
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
N
L
D
L
V
P
Q
A
V
E
E
M
L
R
F
R
F
--
N
L
I
K
-
L
D
R
T
V
K
E
D
N
D
L
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
---------
P
N
N
K
K
H
L
T
F
G
-
N
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
K
K
F
K
H
I
E
A
V
PSF
Q
L
---
E
E
N
--
L
--
T
D
S
-
A
-
T
G
----------------
46
HHSearch
52.55
26%
0
* C2 *
4MM0
1
?
A:
[11-399]
------
H
P
Y
P
F
D
R
A
V
--
P
T
A
I
P
P
L
Y
E
E
L
-
R
-
E
-
T
E
R
V
A
-----
A
I
T
----------
M
ATG
D
P
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
P
R
-
F
S
V
---
R
Q
--
D
L
PG
A
---
P
R
------
L
---
T
E
M
T
F
E
S
V
M
T
------
T
D
P
P
V
-----
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
G
A
P
-
A
-
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
S
L
T
G
------
Y
S
M
E
D
W
T
A
--
A
R
D
A
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
A
L
V
A
T
A
A
E
D
N
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
-
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
--
A
G
D
G
A
L
F
R
V
T
L
E
D
V
T
I
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
D
D
P
T
G
L
R
L
D
R
P
D
----------
N
Q
H
T
A
L
G
-
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
L
------
A
L
---
A
T
D
--
E
SG
L
R
W
S
S
-
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
---
16
PsiBlast_PDB
52.54
27%
-8
- C2 -
2JJO
2
ERYK_SACEN
A:
[33-382]
-----------------------
W
L
G
T
M
-
R
-
E
-
K
Q
P
V
------
W
Q
D
----------
R
---
Y
G
V
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
DP-
T
R
--
V
I
--
E
---
G
A
------
S
---
P
T
P
G
--
M
I
H
E
------
I
D
P
P
E
-----
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
---
D
-
A
G
E
-
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
--
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
--
P
F
P
Q
-
M
Q
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
K
--------
S
G
G
A
A
Q
L
S
F
G
-
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
------
T
V
---
D
R
D
-----------------------------
18
PsiBlast_PDB
52.49
27%
-10
- C2 -
2XFH
4
ERYK_SACEN
A:
[33-382]
-----------------------
W
L
G
T
M
-
R
-
E
-
K
Q
P
V
------
W
Q
D
----------
R
---
Y
G
V
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
DP-
T
R
--
V
I
--
E
---
G
A
------
S
---
P
T
P
G
--
M
I
H
E
------
I
D
P
P
E
-----
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
---
D
-
A
G
E
-
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
--
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
--
P
F
P
Q
-
M
Q
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
K
--------
S
G
G
A
A
Q
L
S
F
G
-
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
------
T
V
---
D
R
D
-----------------------------
14
PsiBlast_PDB
52.46
27%
-9
- C2 -
2WIO
1
ERYK_SACEN
A:
[53-402]
-----------------------
W
L
G
T
M
-
R
-
E
-
K
Q
P
V
------
W
Q
D
----------
R
---
Y
G
V
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
DP-
T
R
--
V
I
--
E
---
G
A
------
S
---
P
T
P
G
--
M
I
H
E
------
I
D
P
P
E
-----
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
---
D
-
A
G
E
-
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
--
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
--
P
F
P
Q
-
M
Q
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
K
--------
S
G
G
A
A
Q
L
S
F
G
-
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
------
T
V
---
D
R
D
-----------------------------
20
PsiBlast_PDB
51.94
26%
12
- C2 -
3WVS
8
?
A:
[49-401]
--------------------------------------------------------------
A
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
--
D
A
R
F
S
---
R
A
--
L
S
--
E
---
E
H
------
D
---
P
P
R
A
R
K
F
N
A
Q
AKSMFN
M
D
A
P
D
-----
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
-
K
G
E
P
A
-
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
--
L
S
T
S
T
L
N
P
E
E
G
R
V
K
R
M
------
E
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
E
A
R
D
V
Q
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
-
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
LG
S
G
S
A
-
A
P
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
P
----------
S
N
H
H
I
G
F
G
-
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
P
T
L
------
K
V
---
A
G
D
--
I
--
A
W
--
K
-
S
E
M
M
V
R
G
P
R
S
M
P
V
G
W
---
19
PsiBlast_PDB
51.86
27%
-4
- C2 -
3ZKP
2
ERYK_SACEN
A:
[33-382]
-----------------------
W
L
G
T
M
-
R
-
E
-
K
Q
P
V
------
W
Q
D
----------
R
---
Y
G
V
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
T
F
S
S
---
D
P
TR
V
I
--
E
---
G
A
------
S
---
P
T
P
G
A
--
I
H
E
------
I
D
P
P
E
-----
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
---
D
-
A
G
E
-
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
A
L
V
D
I
Q
M
D
D
P
T
D
P
A
L
A
E
R
I
A
D
--
V
L
N
P
L
T
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
G
D
D
L
I
S
R
L
V
L
A
E
V
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
R
P
--
P
F
P
Q
-
M
Q
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
K
--------
S
G
G
A
A
Q
L
S
F
G
-
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
------
T
V
---
D
R
D
-----------------------------
10
PsiBlast_PDB
51.71
28%
26
- C2 -
2YCA
6
MYCG_MICGR
A:
[43-417]
------------------------
Y
G
E
L
-
Q
-
E
-
T
E
P
V
S
R
V
R
P
P
Y
G
E
---------------
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
G
---
P
S
--
M
T
--
R
DEP
R
T
------
R
---
P
E
M
V
K
G
G
L
L
S
------
M
D
P
P
E
-----
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
-
T
G
Q
P
A
-
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
---
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
-----
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
LG
V
G
T
A
-
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
----------
P
N
Q
H
L
G
F
G
-
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
------
R
L
GIP
E
T
Q
--
L
--
R
W
S
-
E
--
G
M
L
L
R
G
P
L
E
L
P
V
V
W
---
43
HHSearch
51.69
18%
-24
- C2 -
4C9L
3
?
A:
[33-416]
-----------
L
D
G
L
--
E
Q
G
F
H
E
A
W
K
R
V
-
Q
Q
P
D
T
P
P
L
V
-----
W
T
P
----------
F
T--
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
---
R
V
--
I
W
V-
P
---
R
E
------
A
---
G
E
A
Y
D
M
V
P
T
K
------
L
D
P
P
E
-----
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
-
R
G
H
-
C
-
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
A
N
E
M
T
R
P
S
G
N
T
P
E
--
E
Q
G
R
S
L
E
A
--
A
N
K
G
F
F
E
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
R
I
L
N
V
E
I
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
-
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
--
V
V
S
D
--
A
R
Y
V
V
S
D
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
G
L
D
D
R
H
H
D
D
P
M
T
V
D
L
S
R
R
D
----------
V
T
H
S
T
F
A
-
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
------
R
L
---
K
D
R
--
A
--
V
P
I
-
Y
-
H
S
G
I
V
A
A
V
E
N
I
P
L
E
W
E
P
-
47
HHSearch
51.65
24%
12
- C2 -
3IVY
1
CP125_MYCTU
A:
[25-427]
------
G
F
D
F
T
D
P
A
I
Y
A
E
R
L
P
V
A
E
F
A
E
L
-
R
-
S
-
A
A
P
I
W
-----
W
N
G
QDPGKGGGFH
D
---
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
S
---
Y
E
--
N
G
V-
I
P--
R
F
KNDI--
A
R
E
D
I
E
V
Q
R
F
V
M
L
N
------
M
D
A
P
H
-----
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
I
A
A
E
A
A
A
-
A
G
S
-
G
-
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
Q
E
D
R
G
K
L
F
H
W
S
N
E
M
T
G
N
E
D
--
P
E
Y
A
--
H
I
D
P
K
A
--
S
S
A
E
L
I
G
Y
A
M
K
M
A
E
E
K
-------
I
V
T
Q
L
I
Q
A
D
--
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
-
E
H
P
D
Q
W
E
-
L
Y
K
K
V
-
R
P
E
T
A
A
D
E
I
V
R
W
A
T
--
P
V
T
A
-
F
Q
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
N
P
----------
N
P
H
V
G
F
G
G
T
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
------
K
P
---
I
S
A
-----
P
E
R
-
L
-
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
36
HHSearch
51.49
24%
-18
- C2 -
4E2P
4
?
A:
[21-417]
---------
M
T
T
P
A
E
--
R
W
G
I
H
P
E
H
F
W
L
-
Y
-
G
-
R
R
P
R
Q
-----
M
V
E
----------
F
D
EK
M
N
A
W
N
V
Y
G
Y
A
E
A
I
E
V
L
G
D
P
G
T
F
S
S
---
H
M
--
S
R
LL------------------
F
T
E
G
D
L
L
Q
------
T
D
P
P
D
-----
H
R
E
L
R
K
L
V
S
H
A
F
T
P
K
V
V
A
E
L
E
P
R
I
T
A
L
T
Q
E
L
L
D
A
V
A
D
-
R
D
T
-
F
-
D
L
M
T
A
L
A
Y
P
L
P
V
T
V
V
A
E
L
L
S
I
P
S
A
D
R
H
L
F
E
G
W
M
T
E
I
V
H
S
--------------
M
A
--
P
M
R
K
M
L
E
Y
L
R
E
H
A
A
E
C
R
R
R
P
R
G
D
L
M
G
K
L
I
E
A
E
V
D
G
R
R
L
T
D
N
H
I
V
N
F
A
K
M
L
L
I
A
G
Y
L
T
T
T
M
L
I
G
N
T
V
L
C
L
D
-
S
Y
P
E
Q
A
A
R
V
R
A
D
R
S
L
I
P
G
L
L
E
E
S
M
R
F
L
S
--
P
V
A
A
-
T
Y
R
A
T
T
R
D
V
E
V
A
G
Q
R
L
S
A
D
Q
M
V
M
V
W
F
G
A
A
N
R
D
A
R
Q
F
A
E
P
E
L
F
D
M
T
R
G
P
----------
N
P
H
L
G
F
G
-
R
G
I
H
F
C
L
G
G
P
L
A
R
M
E
G
R
V
A
L
D
H
L
L
D
R
F
-
P
E
------
L
Y
---
T
D
P
E
R
P
--
P
T
F
-
M
-
P
G
F
D
T
T
G
V
S
S
L
P
L
R
T
S
--
7
PsiBlast_PDB
51.49
28%
26
- C2 -
2Y5Z
8
MYCG_MICGR
A:
[43-417]
------------------------
Y
G
E
L
-
Q
-
E
-
T
E
P
V
S
R
V
R
P
P
Y
G
E
---------------
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
G
---
P
S
--
M
T
--
R
DEP
R
T
------
R
---
P
E
M
V
K
G
G
L
L
S
------
M
D
P
P
E
-----
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
-
T
G
Q
P
A
-
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
---
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
-----
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
LG
V
G
T
A
-
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
----------
P
N
Q
H
L
G
F
G
-
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
------
R
L
GIP
E
T
Q
--
L
--
R
W
S
-
E
--
G
M
L
L
R
G
P
L
E
L
P
V
V
W
---