@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu36290: (2016-07-31 )
MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRAHFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYEVFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQELFEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQALKRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHGVAHMMKHLL
Atome Classification :
(20 SA)
.........10....-.-.-..-20........-30........40........50...-...------.---.---60.........70.-.......80........90.-.....--.-.100.-.......110.-...-...120.......---130.......140..--.....150.......160.......170....---...180......--.--190..-.--.....200.......210.......220.......230.......240.......250.......260.....--..270........280...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
I
A
I
DLDG
T
L
LNS-K-
H
-
Q
V
-SLE
N
E
N
A
L
R
Q
-
A
Q
RD
G
I
E
V
V
V
STGRA
H
F
D
V
M
S
I
F
EP-LG
I
------
K
---
T
---
W
-
V
I
SAN
G
A
V
I
HDP-EG
R
L
Y
H
H
ETI
D
K
K
R
A
Y
D
I
L
S
-
W
L
ESE--
N
-
Y
Y
-
Y
E
-
V
FTG
S
A
I
YTPQ-NG
R
-
E
L
L
D
V
E
L
D
R
FRSA---NP
E
A
D
L
S
V
L
K
Q
A
A
E
V
--QYSQS
G
F
A
Y
I
N
S
F
Q
E
L
FEADEP
I
D
F
Y
N
I
L
G
F
S
---
F
F
K
E
K
L
E
A
G
W
K
R
--Y--E-HAE-
D
--
L
T
L
V
SSAEH
N
F
ELSSRKAS
K
G
Q
A
L
K
R
L
A
K
Q
LNI
P
L
E
E
T
AAVGDSLN
D
K
S
M
L
E
A
AGKGVAMG
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L-TNDE
H
G
V
A
H
M
M
K
H
LL
99
HHSearch
85.93
100%
-63
* C2 *
1NRW
3
YWPJ_BACSU
A:
[4-288]
M
K
L
I
A
I
D
L
D
G
T
L
L
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
E
N
A
L
R
Q
-
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
-
L
G
I
------
K
---
T
---
W
-
V
I
S
A
N
G
A
V
I
H
D
P
-
E
G
R
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
-
W
L
E
S
E
--
N
-
Y
Y
-
Y
E
-
V
F
T
G
S
A
I
Y
T
P
Q
-
N
G
R
-
E
L
L
D
V
E
L
D
R
F
R
S
A
---
N
P
E
A
D
L
S
V
L
K
Q
A
A
E
V
--
Q
Y
S
Q
S
G
F
A
Y
I
N
S
F
Q
E
L
F
E
A
D
E
P
I
D
F
Y
N
I
L
G
F
S
---
F
F
K
E
K
L
E
A
G
W
K
R
--
Y
--
E
-
H
A
E
-
D
--
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L
-
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
1
PsiBlast_PDB
85.34
98%
-62
- C2 -
1NRW
3
YWPJ_BACSU
A:
[5-288]
-
K
L
I
A
I
D
L
D
G
T
L
L
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
E
N
A
L
R
Q
-
A
Q
R
D
G
I
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
E
P
-
L
G
I
------
K
---
T
---
W
-
V
I
S
A
N
G
A
V
I
H
D
P
-
E
G
R
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
-
W
L
E
S
E
--
N
-
Y
Y
-
Y
E
-
V
F
T
G
S
A
I
Y
T
P
Q
-
N
G
R
-
E
L
L
D
V
E
L
D
R
F
R
S
A
---
N
P
E
A
D
L
S
V
L
K
Q
A
A
E
V
--
Q
Y
S
Q
S
G
F
A
Y
I
N
S
F
Q
E
L
F
E
A
D
E
P
I
D
F
Y
N
I
L
G
F
S
---
F
F
K
E
K
L
E
A
G
W
K
R
--
Y
--
E
-
H
A
E
-
D
--
L
T
L
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
--
V
T
L
-
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
113
HHSearch
55.40
26%
-46
- C2 -
2PQ0
-
?
A:
[3-254]
R
K
I
V
F
F
D
I
D
G
T
L
L
D
E
-
Q
-
K
-
Q
L
-
P
L
S
T
I
E
A
V
R
R
-
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
Q
-
L
G
I
------
D
-------
S
-
F
V
S
F
N
G
Q
Y
V
V
F
--
E
G
N
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
-
E
A
H
K
N
--
G
-
H
P
-
L
V
-
F
M
D
A
E
K
M
R
A
S
I
G
D
H
P
-
H
I
----
H
V
---
S
M
---
A
-
S
L
K
-------------
F
A
H
P
--
P
-
V
D
---
P
L
--
Y
Y
E
N
K
D
I
Y
Q
A
L
L
F
C
---
R
A
E
E
E
-
E
---
P
Y
--
V
--
R
-
N
Y
P
-
E
--
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
--
V
T
K
-
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
-
102
HHSearch
54.81
28%
-40
- C2 -
3PGV
9
?
A:
[21-283]
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
P
-
D
-
H
-
F
L
-
T
P
Y
A
K
E
T
L
K
L
-
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
N
-
L
G
I
------
R
---
S
---
Y
-
M
I
T
S
N
G
A
R
V
H
D
S
-
D
G
Q
Q
I
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
-
I
V
R
N
D
--
P
K
I
V
-
T
N
-
V
Y
R
E
D
E
W
Y
M
N
R
-
H
R
----------
F
F
K
E
A
---
V
-------------------
F
N
-
Y
K
L
-
Y
E
P
G
E
L
----
D
P
Q
G
I
S
K
V
F
F
T
C
---
E
D
H
E
H
L
L
P
L
E
Q
A
--
M
--
N
A
R
W
G
-
D
R-
V
N
V
S
F
S
T
L
T
C
L
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
V
I
G
-
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
12
PsiBlast_PDB
54.41
20%
-33
- C2 -
3FZQ
7
?
A:
[6-269]
-
K
L
L
I
L
D
I
D
G
T
L
R
D
E
-
V
-
Y
-
G
I
-
P
E
S
A
K
H
A
I
R
L
-
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
L
S
-
L
G
V
------
D
---
G
---
Y
-
I
--
A
G
G
G
N
Y
I
Q
Y
-
H
G
E
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
-
L
L
K
K
R
--
E
-
V
A
-
F
S
-
I
E
S
Q
E
K
V
F
M
N
Q
-
K
A
K
-
E
I
F
E
T
M
-
N
Q
L
K
G
T
---
N
S
---------
C
I
N
K
--
Q
H
I
Q
E
K
I
T
Y
E
N
N
I
E
E
Y
----
K
S
Q
D
I
H
K
I
C
L
W
S
N
E
K
V
F
D
E
V
K
D
I
L
Q
D
K
--
M
--
E
-
L
A
Q
-
R
------
D
I
S
S
Q
Y
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
--
I
C
E
-
D
I
F
D
N
G
I
Y
K
E
L
K
---
111
HHSearch
53.70
25%
-46
- C2 -
3DNP
1
YHAX_BACSU
A:
[6-274]
K
Q
L
L
A
L
N
I
D
G
A
L
L
R
S
-
N
-
G
-
K
I
-
H
Q
A
T
K
D
A
I
E
Y
-
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
A
Q
K
I
A
K
S
-
L
K
L
------
D
---
A
---
K
-
L
I
T
H
S
G
A
Y
I
A
E
K
-
I
D
A
P
F
F
E
K
R
I
S
D
D
H
T
F
N
I
V
Q
-
V
L
E
S
Y
--
Q
-
C
N
-
I
R
-
L
L
H
E
--
K
Y
S
I
G
-
N
K
K
-
K
V
N
---
S
N
L
L
G
K
A
-----
L
I
H
------
P
S
D
P
--
I
F
Y
P
V
--
Q
F
V
E
S
L
S
D
L
L
-
M
D
E
P
V
S
A
P
V
I
E
V
Y
T
---
E
H
-
D
I
Q
H
D
I
T
E
T
--
I
--
T
K
A
F
P
-
A
--
V
D
V
I
R
V
N
D
E
K
L
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
W
--
V
T
R
-
S
N
D
E
Q
G
V
A
Y
M
M
K
E
Y
F
100
HHSearch
52.83
22%
-42
- C2 -
3FZQ
7
?
A:
[5-271]
Y
K
L
L
I
L
D
I
D
G
T
L
R
D
E
-
V
-
Y
-
G
I
-
P
E
S
A
K
H
A
I
R
L
-
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
L
S
-
L
G
V
------
D
-------
G
-
Y
I
A
G
G
G
N
Y
I
Q
Y
--
H
G
E
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
-
L
L
K
K
R
--
E
-
V
A
-
F
S
-
I
E
S
Q
E
K
V
F
M
N
Q
-
K
A
K
-
E
I
-------
F
E
T
M
---
N
-
Q
L
K
G
T
N
S
C
I
N
K
-
Q
--
H
I
Q
E
K
-
I
T
Y
E
N
---
N
I
E
-
E
Y
K
S
Q
D
I
H
K
I
C
L
W
S
---
N
E
K
-
V
F
D
E
V
K
D
I
--
L
--
Q
D
K
M
E
----
L
A
Q
R
D
I
S
S
Q
Y
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
--
I
C
E
-
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
-
105
HHSearch
52.71
26%
5
- C2 -
1NF2
3
?
A:
[2-261]
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
I
E
K
-
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
Y
F
K
R
------
T
---
F
---
P
-
T
I
A
Y
N
G
A
I
V
Y
L
P
-
E
E
G
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
-
Y
I
K
P
L
--
N
-
V
H
-
W
Q
-
A
Y
I
D
D
V
L
Y
S
E
K
-
D
N
E
-
E
-----
I
K
S
Y
A
R
H
-----
S
-----------------
N
V
D
Y
R
V
E
P
N
L
S
E
L
V
---
S
K
M
G
T
T
K
L
L
L
I
D
---
T
P
E
-
R
L
D
E
L
K
E
I
--
L
--
S
E
R
F
K
-
D
V-
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
--
V
T
L
-
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
-
110
HHSearch
52.52
28%
9
- C2 -
4DW8
4
?
A:
[5-268]
Y
K
L
I
V
L
D
L
D
G
T
L
T
N
S
-
K
-
K
-
E
I
-
S
S
R
N
R
E
T
L
I
R
-
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
-
L
R
M
NEF---
G
---
G
---
F
-
I
L
S
Y
N
G
G
E
I
I
N
W
E
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
-
C
A
R
T
N
--
H
-
L
S
-
I
L
-
T
Y
D
G
A
E
I
V
T
E
N
-
S
L
D
-
P
Y
V
-
Q
K
E
A
F
L
N
K
-------------------------
M
--
A
-
I
R
E
T
N
D
F
L
-
T
D
I
T
L
P
V
A
K
C
L
I
V
G
---
D
A
G
-
K
L
I
P
V
E
S
E
--
L
--
C
I
R
L
Q
-
G
K-
I
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
--
I
T
L
-
T
N
D
E
D
G
V
A
E
A
I
E
R
I
-
106
HHSearch
52.43
24%
11
- C2 -
2B30
2
?
A:
[27-297]
I
K
L
L
L
I
D
F
D
G
T
L
F
V
D
K
D
-
I
-
K
V
-
P
S
E
N
I
D
A
I
K
E
-
A
I
E
K
G
Y
M
V
S
I
C
T
G
R
S
K
V
G
I
L
S
A
F
G
E
-
E
N
L
K
K
M
NFY
G
---
M
---
P
-
G
V
Y
I
N
G
T
I
V
Y
D
Q
-
I
G
Y
T
L
L
D
E
T
I
E
T
D
V
Y
A
E
L
I
S
-
Y
L
V
E
K
--
N
-
L
V
N
Q
T
I
F
H
R
G
E
S
N
Y
V
T
E
-
D
N
K
-
Y
-----
A
D
F
L
Q
K
M
---
Y
------------------
S
E
N
R
S
I
I
I
R
-
H
N
E
---
M
L
K
Y
R
T
M
N
K
L
M
I
V
L
---
D
P
S
-
E
S
K
T
V
I
G
N
--
L
--
K
Q
K
F
K
-
N
K-
L
T
I
F
T
T
Y
N
G
H
A
E
V
T
K
L
G
H
D
K
Y
T
G
I
N
Y
L
L
K
H
Y
N
I
S
N
D
Q
V
L
V
V
G
D
A
E
N
D
I
A
M
L
S
N
F
K
Y
S
F
A
V
A
N
A
T
D
S
A
K
S
H
A
K
C
--
V
L
P
V
S
H
R
E
G
A
V
A
Y
L
L
K
K
V
F
4
PsiBlast_PDB
51.14
25%
-5
- C2 -
1NF2
3
?
A:
[3-261]
-
R
V
F
V
F
D
L
D
G
T
L
L
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
I
E
K
-
L
S
R
K
C
Y
-
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
K
-
Y
F
K
------
R
---
T
---
F
P
T
I
A
Y
N
G
A
I
V
Y
L
P
-
E
E
G
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
-
Y
I
K
P
L
--
N
-
V
H
-
W
Q
-
A
Y
I
D
D
V
L
Y
S
E
K
-
D
N
E
-
E
I
------
K
S
Y
A
R
---
H
S
N
V
D
Y
R
V
E
P
N
L
S
E
L
V
S
K
M
G
T
T
K
L
L
L
I
D
T
P
E
R
L
D
E
------------------
L
K
E
I
L
S
E
R
F
K
----------
D
-
V
--
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
--
V
T
L
-
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
-
10
PsiBlast_PDB
51.11
25%
-47
- C2 -
2PQ0
-
?
A:
[4-254]
-
K
I
V
F
F
D
I
D
G
T
L
L
D
E
-
Q
-
K
-
Q
L
-
P
L
S
T
I
E
A
V
R
R
-
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
Q
-
L
G
I
------
D
---
S
---
F
-
V
-
S
F
N
G
Q
Y
V
V
F
--
E
G
N
V
L
Y
K
Q
P
L
R
R
E
K
----
V
R
-
A
L
T
E
E
--
A
-
H
---------------
K
-
N
G
H
-
P
L
V
F
M
D
A
E
K
M
R
A
S
IGD
H
P
H
I
H
V
S
----
M
A
S
L
--
K
F
A
H
P
------
P
V
D
P
L
Y
Y
E
N
K
--
D
I
Y
Q
A
L
L
F
C
---
R
A
E
E
E
-
E
P
Y
V
R
N
--
Y
--
P
-----
E
--
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
--
V
T
K
-
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
-
115
HHSearch
50.83
21%
-67
- C2 -
1WR8
1
PGP_PYRHO
A:
[3-225]
I
K
A
I
S
I
D
I
D
G
T
I
T
Y
P
-
N
-
R
-
M
I
-
H
E
K
A
L
E
A
I
R
R
-
A
E
S
L
G
I
P
I
M
L
V
T
G
N
T
V
Q
F
A
E
A
A
S
I
L
-
I
G
T
------
S
---
G
---
P
-
V
V
A
E
D
G
G
A
I
S
Y
K
--
K
K
R
I
F
L
A
S
M
D
E
E
W
--
I
L
W
N
-
E
I
R
K
R
----------
F
P
N
A
----------
R
-
T
------
S
-
Y
T
M
P
---
D
-
R
-----------------
R
A
G
L
V
I
M
R
-------
E
------------
T
---
I
N
V
E
T
V
R
E
I
I
N
E
--
L
--
N
--
L
--
N
--
L
V
A
-
V
D
S
G
F
A
I
H
V
K
K
P
W
I
N
K
G
S
G
I
E
K
A
S
E
F
L
G
I
K
P
K
E
V
A
H
V
G
D
G
E
N
D
L
D
A
F
K
V
V
G
Y
K
V
A
V
A
Q
A
P
K
I
L
K
E
N
A
D
Y
--
V
T
K
-
K
E
Y
G
E
G
G
A
E
A
I
Y
H
I
L
11
PsiBlast_PDB
50.70
25%
-44
- C2 -
2QYH
5
?
A:
[4-254]
-
K
I
V
F
F
D
I
D
G
T
L
L
D
E
-
Q
-
K
-
Q
L
-
P
L
S
T
I
E
A
V
R
R
-
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
Q
-
L
G
I
------
D
---
S
---
F
-
V
-
S
F
N
G
Q
Y
V
V
F
--
E
G
N
V
L
Y
K
Q
P
L
R
R
E
K
----
V
R
-
A
L
T
E
E
--
A
-
H
---------------
K
-
N
G
H
-
P
L
V
F
M
D
A
E
K
M
R
A
S
IGD
H
P
H
I
H
V
S
----
M
A
S
L
--
K
F
A
H
P
------
P
V
D
P
L
Y
Y
E
N
K
--
D
I
Y
Q
A
L
L
F
C
---
R
A
E
E
E
-
E
P
Y
V
R
N
--
Y
--
P
-----
E
--
F
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
--
V
T
K
-
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
-
107
HHSearch
50.11
28%
18
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[5-270]
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
-
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
-
L
H
M
------
E
QPG
D
---
Y
-
C
I
T
Y
N
G
A
L
V
Q
K
A
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
-
L
S
R
E
V
--
G
-
S
H
-
F
H
-
A
L
D
R
T
T
L
Y
T
A
N
--
R
D
-
I
------
S
Y
Y
-
T
V
---
H
E
S
F
-------
V
A
------
T
I
P
--
L
V
F
C
E
A
E
K
M
---
D
P
N
T
Q
F
L
K
V
M
M
I
D
---
E
P
A
-
I
L
D
Q
A
I
A
R
--
I
--
P
Q
E
V
K
E
K
--
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
--
V
T
K
-
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
114
HHSearch
49.98
26%
-4
- C2 -
3R4C
4
?
A:
[12-266]
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
-
E
T
H
-
K
V
-
S
Q
S
S
I
D
A
L
K
K
-
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
D
-
A
-
V
P
-------
Y
---
D
---
G
-
V
I
A
L
N
G
A
E
C
V
L
R
-
D
G
S
V
I
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
-
L
A
R
E
F
--
D
-
F
A
-
V
A
-
L
E
L
N
E
G
V
F
V
N
R
-
L
T
P
-
T
-----
V
E
Q
I
A
G
I
---
V
-
E
-----------------
H
P
-
V
P
P
V
V
D
I
E
E
M
F
-
E
--
R
K
E
C
C
Q
L
C
F
Y
F
---
D
E
E
-
A
E
Q
K
V
M
P
L
--
L
--
S
-----
G
--
L
S
A
T
R
W
H
P
L
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
--
V
T
D
-
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
3
PsiBlast_PDB
49.97
29%
26
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[5-263]
I
K
L
I
A
I
D
M
D
G
T
L
L
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
-
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
E
-
L
H
M
------
E
---
Q
PG
D
Y
-
C
I
T
Y
N
G
A
L
V
Q
K
A
-
A
D
G
S
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
-
K
L
S
R
E
V
-
G
-
S
H
-
F
H
-
A
L
D
R
T
T
L
Y
T
A
N
-
R
D
I
-
S
Y
Y
T
V
H
-
E
S
F
V
A
T
---
I
P
L
V
F
C
E
A
E
K
M
D
P
N
T
--
Q
-----------
F
L
K
V
M
M
I
D
E
P
----------------
A
I
L
D
Q
A
I
A
R
--
I
P
Q
E
-
V
K
E
-
K
--
Y
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
--
V
T
K
-
S
N
L
E
D
G
V
A
-------
20
PsiBlast_PDB
49.29
23%
-11
- C2 -
1RLT
3
SUPH_ECOLI
A:
[3-263]
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
-
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
I
S
F
F
P
E
-
L
K
D
------
E
---
I
---
S
-
F
V
A
E
N
G
A
L
V
Y
E
H
-
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
-
L
L
K
D
K
--
Q
-
L
N
-
F
V
-
A
C
G
L
Q
S
A
Y
V
S
E
-
N
A
-------------------
P
E
A
F
V
A
L
M
A
K
H
Y
H
R
--
L
K
P
V
K
D
Y
Q
E
I
D
D
V
L
F
K
F
S
L
N
L
P
---------------
D
E
Q
I
P
L
V
I
D
K
--
L
--
H
-
V
A
L
-
D
GI
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
103
HHSearch
49.19
23%
8
- C2 -
3DAO
1
?
A:
[21-283]
I
K
L
I
A
T
D
I
D
G
T
L
V
K
D
-
G
-
S
L
L
I
-
D
P
E
Y
M
S
V
I
D
R
-
L
I
D
K
G
I
I
F
V
V
C
S
G
R
Q
F
S
S
E
F
K
L
F
A
P
-
I
K
H
------
K
---
L
---
L
-
Y
I
T
D
G
G
T
V
V
R
T
P
--
K
E
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
M
C
R
-
M
V
R
D
E
LP
A
-
C
D
-
Y
F
-
A
A
T
P
D
F
C
F
A
E
D
-
G
G
S
-
P
I
----
F
H
L
L
R
D
S
---
Y
-
G
------------------
F
E
M
R
E
V
D
D
I
T
R
----
L
D
R
N
D
I
I
K
F
T
V
F
H
---
P
D
K
--
C
E
E
L
C
T
P
VF
I
--
P
-
A
W
N
K
K
--
A
H
L
A
A
A
G
K
E
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
--
T
C
A
-
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
104
HHSearch
48.81
22%
20
- C2 -
1RLM
3
SUPH_ECOLI
A:
[3-263]
V
K
V
I
V
T
D
M
D
G
T
F
L
N
D
-
A
-
K
-
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
-
L
K
K
R
G
I
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
I
S
F
F
P
E
-
L
K
D
------
E
---
I
---
S
-
F
V
A
E
N
G
A
L
V
Y
E
H
--
G
K
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
K
--
Q
-
L
N
-
F
V
-
A
C
G
L
Q
S
A
Y
V
S
E
-
N
A
P
E
A
F
----
V
A
L
M
A
K
------
H
Y
H
---------------
R
L
--
K
P
V
K
D
Y
Q
-----
E
I
D
D
V
L
F
K
F
S
L
N
L
---
P
-
D
E
Q
I
P
L
V
I
D
K
--
L
--
H
V
A
L
D
-
G
I-
M
K
P
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
--
A
T
D
-
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L