@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38580: (2016-08-04 )
MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSFFLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVDALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVSTEIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNIVSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIAFQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFNINEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFSGYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEAAL
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------.........10........20..-.-.....30---...------....---.40.....---...50...-.....60.-.......-----70.......--------.80........--------90........100.......110.......120.-.......130-.--......140.......150-...-....-------160-.......--.-170.......180.......190.......200.......210........220.......-------------230......-----..240.......250-----........260...-....270-...-....280.......290.......300.......310.......320.......--330.......340.......350.--------......360.......370.......-380.....---..390.......400..-.....410....------...420......-.430.......440.......450--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------M
N
K
V
N
Q
I
L
E
EKV
M
P
I
A
G
R
I
A
G
Q
R
-
H
-
L
Q
A
L
RD
G
---
I
I
L
------
T
M
P
L
---
I
I
I
G
S
F
F
L
---IIGNLPIP-
G
Y
A
E
F
M
A
K
-
T
FGSS
W
S
-----EKLAYPV
D
A
--------
T
F
E
I
M
G
L
V
A
A
F
--------
G
I
A
Y
R
L
A
E
K
YGV
D
A
LS
A
G
A
I
S
L
A
A
F
L
LATPY-QV-PFMPDGAT
K
E
-
I
--
M
VGGGI
P
L
S
LMGSK
G
L
F
V
A
-
M
I
I
-
A
M
V
S
-------
T
E
--
I
Y
R
L
I
I
Q--R-N
L
V
F
KMPDGVP
P
A
V
S
K
S
F
V
A
L
I
P
G
F
A
V
I
F
L
I
W
A
A
R
L
I
VEAT
P
-
F
E
S
L
H
N
I
V
S
V
L
LGT
P
L
S
I
-------------
L
-GGSL
G
G
S
-----
L
V
A
E
A
V
K
M
L
L
W
A
CG------LHG
A
N
I
V
G
G
V
M
A
P
I
-
W
YGAMDA-
N
R
I
-
A
F
Q
A
G
E
E
L
P
K
I
F
T
Q
Q
F
F
D
I
W
VNIGGS
G
A
T
L
A
L
V
V
T
M
F
L
R
A
R
S
K
Q
M
K
Q
L
G
K
LAVG--
P
A
I
FNINE
P
I
I
FG
M
P
I
VM
N
P
M
L
L
L
--------
P
F
I
I
T
P
L
V
T
V
T
L
T
Y
IGMSTGLVAKPA-GIAVPWTM---
P
P
I
F
S
G
Y
LATGG
K
V
S
G
A
-
V
M
Q
A
I
N
I
A
V
S
F
V
------
V
Y
Y
P
F
F
R
M
W
D
K
Q
-KLKEEND
L
E
L
VQTPAATDDKEAAL--------------
10
PsiBlast_CBE
87.88
60%
-153
- C3 -
3QNQ
9
?
C:
[3-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
-
Q
V
-
A
Y
I
M
P
G
T
K
E
S
-
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
Q
--
K
-
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
R
P
S
-
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
------------------------------------
21
Fugue
87.44
59%
-151
- C3 -
3QNQ
8
?
A:
[3-434]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
-
Q
V
-
A
Y
I
M
P
G
T
K
E
S
-
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
Q
--
K
-
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
R
P
S
-
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
A
E
E
K
G
E
A
-----------------------------
11
PsiBlast_CBE
87.42
60%
-150
- C3 -
3QNQ
7
?
B:
[3-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
-
Q
V
-
A
Y
I
M
P
G
T
K
E
S
-
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
Q
--
K
-
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
R
P
S
-
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
------------------------------------
1
PsiBlast_PDB
87.25
60%
-154
- C3 -
3QNQ
8
?
A:
[3-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
-
Q
V
-
A
Y
I
M
P
G
T
K
E
S
-
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
Q
--
K
-
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
R
P
S
-
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
------------------------------------
9
PsiBlast_CBE
87.10
60%
-155
- C3 -
3QNQ
7
?
D:
[3-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
F
-
Q
V
-
A
Y
I
M
P
G
T
K
E
S
-
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
Q
--
K
-
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
R
P
S
-
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
------------------------------------
12
HHSearch
86.19
59%
-139
- C3 -
3QNQ
8
?
A:
[3-434]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
V
A
E
Q
R
-
H
-
L
L
A
I
R
D
G
---
L
V
L
------
T
M
P
F
---
L
I
I
G
S
I
F
L
---
I
I
S
T
L
P
I
P
-
G
Y
S
E
F
M
A
S
-
L
F
G
K
N
W
N
-----
V
A
L
G
Y
P
V
S
A
--------
T
F
N
I
M
A
L
I
A
V
F
--------
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
V
T
F
L
L
A
T
P
--
F
Q
-
V
A
Y
I
M
P
G
T
K
E
S
I
--
L
V
D
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
-
M
I
I
-
A
I
I
S
-------
T
E
--
I
Y
R
F
L
V
---
Q
K
K
M
I
I
K
M
P
E
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
I
R
L
I
F
E
-
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
-------------
L
-
G
A
S
L
W
G
A
-----
V
I
A
V
I
L
V
H
V
L
W
A
C
G
------
I
H
G
A
T
I
V
G
G
V
M
S
P
I
-
W
L
S
L
M
D
Q
-
N
R
I
-
A
F
Q
A
G
Q
D
V
P
N
T
I
T
A
Q
F
F
D
L
W
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
Q
L
K
S
L
G
R
L
S
I
A
--
P
G
I
F
N
I
N
E
M
V
T
F
G
M
P
I
V
M
N
P
L
L
L
I
--------
P
F
I
V
V
P
V
V
L
T
I
V
S
Y
F
A
M
E
W
G
L
V
A
-
R
P
S
G
A
A
V
T
W
T
T
---
P
I
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
V
-
I
L
Q
L
V
N
F
A
L
A
F
V
------
I
Y
L
P
F
L
K
I
W
D
K
Q
-
K
I
A
E
E
K
G
E
A
-----------------------------
25
Fugue
43.35
18%
-21
- C3 -
4KQ7
6
?
A:
[2-374]
------------------------------------------------------------------------------------------------------------------------------------QSNMTN
E
M
F
D
L
A
K
L
K
S
G
V
K
N
K
R
I
S
S
T
D
P
T
G
G
N
R
D
H
-
L
E
P
F
K
P
G
EKR
I
I
A
------
D
I
K
G
M
--
G
V
I
N
H
I
W
V
---
T
I
A
P
P
P
P
T
L
S
R
N
D
I
I
I
R
M
Y
W
D
G
N
D
Y
-----
P
S
V
E
S
P
-----------------
I
G
P
F
F
--------
G
Q
G
W
D
E
R
Y
N
Y
A
S
L
P
L
S
A
G
P
E
N
G
T
G
L
S
C
---
Y
-
F
A
M
P
F
-
E
K
G
A
R
I
E
-
I
--
E
N
Q
S
D
R
N
I
D
---
A
F
Y
F
Y
V
D
-
Y
L
E
M
A
K
L
P
-------
K
D
M
G
R
F
H
A
W
Y
N
--
H
-
N
L
T
E
A
L
P
E
G
------------------------------
E
T
E
-
W
G
V
T
G
A
Q
K
P
N
T
T
G
E
R
N
Y
V
-------------
F
M
E
T
Q
G
K
G
H
-----
F
V
G
I
N
Y
Y
V
H
C
---------------------
P
T
P
M
W
Y
G
E
G
D
D
M
W
----
F
I
D
G
E
K
V
P
S
L
I
G
T
G
T
E
D
F
F
N
T
A
W
C
P
K
E
A
F
S
H
P
Y
F
G
Y
P
R
V
N
-
N
D
I
G
W
L
G
R
T
H
V
----
Y
R
F
F
I
E
D
P
I
F
F
E
K
S
L
K
----------------------------------
G
T
I
E
H
G
S
-
N
N
N
L
T
L
D
L
---
S
T
V
A
Y
W
Y
Q
D
S
A
V
A
L
P
E
A
-
P
T
K
A
Q
R
A
P
K
P
F
I
------
N
H
V
D
I
H
R
W
R
D
A
W
-
R
K
S
K
G
N
K
A
T
L
W
G
N
E
------------------------
23
Fugue
39.45
16%
-63
- C3 -
3RFU
3
?
A:
[74-736]
VSP
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
GHGLKHFISGNG
S
S
W
I
Q
L
L
L
A
T
P
V
V
LWGG
W
P
F
F
K
R
G
W
Q
S
L
K
TGQLN
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
WPGVFPHAFRSQEGVVAVY
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
EQTGS
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
-
V
S
L
D
N
V
A
V
G
---
D
L
L
R
V
R
P
GE
K
I
P
V
D
G
E
V
Q
E
G
R
S
F
V
D
E
S
M
V
T
G
E
P
I
P
-
V
A
K
E
A
S
A
K
-
V
I
G
A
T
I
N
-----
Q
T
G
S
F
V
M
K
A
LHVGSDT
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
SRA
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
-
S
Y
G
L
I
A
A
V
S
V
-
L
--
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
-
G
A
Q
S
GVLIKN
A
E
A
--
L
E
R
M
E
K
V
--
N
-
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
D
F
V
E
D
N
A
L
A
L
A
A
A
L
E
H
Q
S
E
-
H
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
P
TGK
G
V
-
V
G
Q
V
D
G
H
-----
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
-
M
F
M
A
V
D
G
-
K
T
V
-
A
L
L
V
V
E
D
P
I
K
---
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
K
V
V
--
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
VND
A
P
A
L
A
K
A
D
I
G
I
A
M
---
G
T
G
T
D
V
A
I
E
S
A
-
G
V
T
L
L
H
G
D
---
L
----
R
G
I
A
K
A
R
R
L
S
E
S
-
T
M
S
N
I
R
Q
N
L
F
F
A
------
F
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
LKRVTL
30
Fugue
37.23
14%
-51
- C2 -
1IQ8
1
ATGT_PYRHO
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
K
M
L
K
F
E
I
K
A
R
D
---------------
G
A
G
R
I
G
---
K
L
E
------
V
N
G
K
---
K
I
E
T
P
A
I
M
---
P
V
V
N
--------------------
P
-----
K
Q
M
-
V
V
E
P
K
--------
E
L
E
K
M
G
F
E
I
I
I
--------
T
N
S
Y
I
I
Y
K
D
E
E
L
R
R
K
A
L
E
L
-
G
I
H
R
M
L
---
D
Y
-
N
G
-
I
I
E
V
D
S
G
S
F
Q
-
L
--
M
K
Y
----------------G
S
-
I
-
E
V
S
N
-------
R
E
--
I
I
E
F
Q
H
R
I
G
V
-
D
I
G
T
F
L
D
I
P
T
P
P
D
A
P
R
E
Q
A
V
K
E
L
E
I
T
L
S
R
A
R
E
A
E
E
I
K
E
---------
I
P
M
N
A
T
I
Q
G
----------------------
S
T
Y
T
D
-----
L
R
R
Y
A
A
R
R
L
S
S
M
-
N
------
F
E
I
H
P
I
G
G
V
V
P
L
L
E
-
S
Y
R
F
R
D
V
-
V
D
I
-
V
I
S
S
K
M
A
L
R
P
-------
D
R
P
V
H
L
F
G
A
G
H
P
I
V
F
A
L
A
V
A
M
---------------
G
--
V
D
L
F
D
S
A
S
Y
A
L
Y
A
K
D
-----------------
D
R
Y
M
T
P
E
G
T
K
R
L
D
E
L
D
-----
Y
F
P
C
----
S
C
P
V
C
S
K
YT
P
Q
E
L
R
E
M
P
K
---
E
E
R
T
R
-
L
L
A
L
H
N
L
W
V
I
K
E
------
E
I
K
R
V
K
Q
A
I
K
E
G
-
E
L
W
R
L
V
D
E
R
A
R
S
H
P
------------------------
24
Fugue
35.46
9%
-55
- C3 -
3MHS
8
UBP8_YEAST
A:
[5-476]
------------------------------------------------------------------------------------------------------------------------------------------AMSI
C
P
H
I
Q
Q
V
F
Q
N
E
K
S
K
D
G
V
L
K
T
C
N
A
-
A
-
R
Y
I
L
N
H
S
---
V
P
K
------
E
K
F
L
---
N
T
M
K
C
G
T
C
---
H
E
I
N
S
G
-
A
-
T
F
M
C
L
Q
C
G
-
F
C
G
C
W
N
H
-----
S
H
F
L
S
H
S
K
Q
--------
I
G
H
I
F
G
I
N
S
N
N
--------
G
L
L
F
C
F
K
C
E
D
Y
I
G
N
I
D
L
I
N
D
A
I
L
A
K
Y
W
D
D
V
C
-
T
K
-
T
M
V
P
S
M
E
R
R
D
-
G
--
L
S
G
----
L
I
N
M
G
S
T
C
F
M
S
S
-
I
L
Q
-
C
L
I
H
-------
N
P
--
Y
F
I
R
H
S
M
--
S
-
Q
I
H
S
N
N
C
-----
K
V
R
S
P
D
K
C
F
S
C
A
L
D
K
I
V
H
E
L
Y
G
A
L
N
T
S
T
N
R
-
Q
T
G
F
I
Y
L
L
T
C
A
W
K
I
N
Q
N
L
-------------
A
-
G
Y
S
Q
Q
D
A
H
E
F
W
Q
F
I
I
N
Q
I
H
Q
S
Y
V
L
D
L
------
P
N
N
N
K
Q
C
E
C
I
V
H
T
V
-
F
E
G
S
L
E
S
-
S
I
V
-
C
P
G
C
Q
N
N
-
S
K
T
T
I
D
P
F
L
D
L
S
L
D
I
K
D
K
K
-
K
L
Y
E
C
L
D
S
F
H
K
K
E
Q
L
K
D
F
N
------------
Y
H
C
G
E
C
N
S
T
Q
D
A
I
K
Q
L
G
I
H
K
L
--------
P
S
V
L
V
L
Q
L
K
R
F
E
H
L
L
N
G
S
N
R
K
L
D
D
F
I
-
E
F
P
T
Y
L
N
M
---
K
N
Y
C
S
T
K
E
K
D
K
E
N
G
K
V
P
D
I
I
Y
E
L
I
G
I
V
S
H
K
G
TVN
E
G
H
Y
I
A
F
C
K
I
S
G
G
Q
-
W
F
K
F
N
D
S
M
V
S
S
I
S
Q
E
E
V
L
K
E
Q
A
Y
L
L
F
Y
T
IRQVN-----
26
Fugue
33.09
11%
-37
- C3 -
4WZI
5
PDE4B_HUMAN
A:
[85-576]
----------------------------------------------------------------------------------------------------------------------------------------------
V
T
P
F
A
Q
V
L
A
S
L
R
S
V
R
N
N
F
T
I
Q
K
L
-
A
-
M
E
T
L
E
E
L
---
D
W
A
------
L
D
Q
L
---
E
T
I
Q
T
-
Y
R
---
S
V
S
E
M
A
S
N
-
K
F
K
R
M
L
N
R
-
E
L
T
H
L
S
E
M
S
R
C
G
N
Q
V
S
E
Y
I
S
N
--------
T
F
L
D
K
E
N
E
D
H
L
--------
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
A
I
M
Y
-
A
I
--
F
Q
E
R
D
L
L
K
T
-
F
--
R
I
----------
S
S
D
T
F
I
T
-
Y
M
M
-
T
L
E
D
--------------------------
H
Y
H
S
D
V
A
Y
--
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
-
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
-------------------
D
H
P
G
V
S
-----
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
------
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
-
G
F
K
L
L
Q
E
-
E
H
A
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
A
A
D
L
-
S
N
P
T
K
S
L
--------
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
-
E
I
---------
S
P
M
A
D
K
H
T
A
C
V
E
K
S
Q
V
G
-
F
I
D
Y
I
--------------
V
H
P
L
W
E
T
W
--
A
-
D
L
V
Q
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
IP------------
4
PsiBlast_PDB
29.01
30%
-258
- C3 -
2ZII
-
VPS74_YEAST
A:
[250-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
L
A
L
I
C
G
------
S
Y
G
A
N
V
L
E
N
V
L
T
T
L
-
E
Y
E
K
R
D
K
-----
A
I
S
R
A
E
E
I
M
A
Q
F
S
Q
Y
P
F
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
28.59
18%
-28
- C3 -
4D2H
5
COM1_HUMAN
A:
[1-37]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
S
M
S
D
F
K
D
L
W
T
K
L
-
K
E
C
H
D
R
E
V
Q
G
L
Q
V
K
V
T
K
L
K
Q
E
R
I
L
--------------
19
HHSearch
27.72
7%
-334
- C3 -
3D9S
-
AQP5_HUMAN
A:
[204-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
W
V
F
W
-
V
G
P
I
V
G
A
V
L
A
A
I
------
L
Y
F
Y
L
L
F
P
N
S
L
S
-
L
-------------------------------------
2
PsiBlast_PDB
27.55
30%
-311
- C3 -
4TU3
-
VPS74_YEAST
A:
[250-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
L
A
L
I
C
G
------
S
Y
G
A
N
V
L
E
N
V
L
T
T
L
-
E
Y
E
K
R
D
K
-----
A
I
S
R
A
E
E
I
M
A
Q
F
S
Q
Y
P
F
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
27.28
22%
-174
- C1 -
2M7G
-
?
A:
[20-28]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
P
Q
F
S
A
Y
R
-----------------------------------------
3
PsiBlast_PDB
25.93
30%
-261
- C3 -
2ZIH
-
VPS74_YEAST
A:
[250-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
L
A
L
I
C
G
------
S
Y
G
A
N
V
L
E
N
V
L
T
T
L
-
E
Y
E
K
R
D
K
-----
A
I
S
R
A
E
E
I
M
A
Q
F
S
Q
Y
P
F
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
24.53
25%
-62
- C3 -
2WHF
3
CP130_MYCTU
A:
[215-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
--------
A
I
S
H
L
V
A
A
G
V
G
A
D
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
---------
M
V
T
G
G
N
D
T
-
V
T
G
M
L
G
G
S
M
P
L
-------------------------------
L
H
R
R
P
D
Q
--
R
-
R
L
L
L
D
D
P
E
G
I
P
D
A
V
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
24.42
25%
-75
- C3 -
2WH8
2
CP130_MYCTU
A:
[215-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
--------
A
I
S
H
L
V
A
A
G
V
G
A
D
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
---------
M
V
T
G
G
N
D
T
-
V
T
G
M
L
G
G
S
M
P
L
-------------------------------
L
H
R
R
P
D
Q
--
R
-
R
L
L
L
D
D
P
E
G
I
P
D
A
V
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
24.23
25%
-65
- C3 -
2UUQ
2
CP130_MYCTU
A:
[216-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
--------
A
I
S
H
L
V
A
A
G
V
G
A
D
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
---------
M
V
T
G
G
N
D
T
-
V
T
G
M
L
G
G
S
M
P
L
-------------------------------
L
H
R
R
P
D
Q
--
R
-
R
L
L
L
D
D
P
E
G
I
P
D
A
V
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------