@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39640: (2016-08-05 )
MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGSGKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTIGENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIHKPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKDGELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL
Atome Classification :
(30 SA)
.........10....-....20........30........40........50........60........70........80..----------......90........100.....-.----.---110.......120.......----.130-..----...-------...140.......150.......160.......170.......180.......190.......200....-.-..-210----........220-----.......230......--.240.......250.....----------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAN
M
L
E
V
KHINKTYK-G
Q
V
S
Y
Q
A
L
K
Q
I
S
F
S
IEEG
E
F
T
A
V
MGPSGSG
K
T
T
L
L
N
I
I
S
T
IDRPDSG
D
I
L
I
NGEN
P
H
R
L
K
R
T
K
L
A
H
F
R
----------
R
K
Q
L
G
F
V
F
Q
DFNL
L
D
T
L
TIGEN
I
M
-
L
----
P
---
L
T
LEKEA
P
S
V
M
E
-
E
K
L
H
G
I
A
----
A
K
L
--
G
I
----
E
N
L
-------
L
NK
R
T
F
EVSGG
Q
R
Q
R
A
A
I
A
R
A
V
IHKP
S
L
I
L
ADEPTGNLD
S
K
A
T
K
D
V
M
E
T
L
Q
SLNRDD
H
V
T
A
L
M
V
THDPV
S
-
A
-
S
Y
-C-
R
----
R
V
I
F
IKD
G
E
L
F
-----
N
E
I
YRGEN
R
Q
V
F
Y
E
Q
I
--
L
D
V
L
S
M
LGGNANDLSSVRL----------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.16
38%
-97
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[2-223]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
-
G
---
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
----------
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
----
P
---
M
L
K
M
G
K
P
K
K
E
A
K
-
E
R
G
E
Y
L
L
----
S
E
L
--
G
L
----
G
D
K
-------
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
-
A
-
E
L
-
T
-
H
----
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
I
T
R
------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.78
38%
-95
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-223]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
-
G
---
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
----------
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
----
P
---
M
L
K
M
G
K
P
K
K
E
A
K
-
E
R
G
E
Y
L
L
----
S
E
L
--
G
L
----
G
D
K
-------
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
-
A
-
E
L
-
T
-
H
----
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
I
T
R
------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.33
38%
-97
- C1 -
2PCL
12
LOLD_AQUAE
A:
[2-223]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
-
G
---
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
----------
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
----
P
---
M
L
K
M
G
K
P
K
K
E
A
K
-
E
R
G
E
Y
L
L
----
S
E
L
--
G
L
----
G
D
K
-------
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
-
A
-
E
L
-
T
-
H
----
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
I
T
R
------------------------------------------------------------------------------------------------------------------------------------
106
Fugue
81.45
30%
-83
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
-
G
--
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
----------------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
-
F
----
G
---
L
R
E
K
R
V
P
K
D
E
M
D
-
A
R
V
R
E
L
L
----
R
F
M
--
R
L
----
E
S
Y
-------
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
-
A
-
L
E
V
A
-
D
----
R
V
L
V
L
H
E
G
---------
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
GT
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R---
6
PsiBlast_PDB
80.93
34%
-91
- C1 -
2IT1
-
?
A:
[1-236]
---
M
V
E
I
K
-
L
E
N
I
V
K
-
K
F
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
------
K
----------
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
-
F
----
P
---
L
E
L
R
K
A
P
R
E
E
I
D
-
K
K
V
R
E
V
A
----
K
M
L
--
H
I
----
D
K
L
-------
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
-
A
L
A
M
-
A
-
D
----
R
I
A
V
I
R
E
G
E
I
L
-----
Q
---
V
G
T
P
D
E
V
Y
Y
K
P
K
--
Y
K
F
V
G
G
F
L
G
N
-------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.76
34%
-93
- C1 -
2IT1
1
?
B:
[2-236]
----
V
E
I
K
-
L
E
N
I
V
K
-
K
F
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
------
K
----------
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
-
F
----
P
---
L
E
L
R
K
A
P
R
E
E
I
D
-
K
K
V
R
E
V
A
----
K
M
L
--
H
I
----
D
K
L
-------
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
-
A
L
A
M
-
A
-
D
----
R
I
A
V
I
R
E
G
E
I
L
-----
Q
---
V
G
T
P
D
E
V
Y
Y
K
P
K
--
Y
K
F
V
G
G
F
L
G
N
-------------------------------------------------------------------------------------------------------------
102
Fugue
78.44
32%
-96
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
-
I
I
V
K
N
V
S
K
V
F
K
-
K
G
-
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
----------
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
----
P
---
L
T
N
M
K
M
S
K
E
E
I
R
-
K
R
V
E
E
V
A
----
K
I
L
--
D
I
----
H
H
V
-------
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
-
I
-
F
A
I
A
-
D
----
R
V
G
V
L
V
K
G
K
L
V
-----
Q
V
---
G
K
P
E
D
L
Y
D
N
P
V
--
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
NEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
98
PsiBlast_CBE
76.13
33%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-233]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
-
V
R
----------
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
----
G
---
L
G
N
G
K
G
R
T
A
Q
E
R
-
Q
R
I
E
A
M
L
----
E
L
T
--
G
I
----
S
E
L
-------
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
-
A
L
Q
Y
-
A
-
D
----
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.53
42%
18
- C1 -
3TIF
7
Y796_METJA
A:
[1-226]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
----
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
-
E
R
R
K
R
A
L
----
E
C
L
--
K
M
A
ELE
E
R
F
-------
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
-
A
-
R
F
-
G
-
E
----
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
---------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
74.84
36%
-103
- C1 -
2IT1
-
?
A:
[3-220]
---
E
I
K
L
E
N
I
V
K
K
F
G
-
N
---
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
------
K
----------
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
-
F
----
P
---
L
E
L
R
K
A
P
R
E
E
I
D
-
K
K
V
R
E
V
A
----
K
M
L
--
H
I
----
D
K
L
-------
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
-
A
M
-
A
-
D
----
R
I
A
V
I
R
E
G
E
I
L
-----
Q
V
G
T
P
D
E
----------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
74.20
33%
-99
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[2-228]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
-
V
R
----------
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
----
G
---
L
G
N
G
K
G
R
T
A
Q
E
R
-
Q
R
I
E
A
M
L
----
E
L
T
--
G
I
----
S
E
L
-------
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
-
A
L
Q
Y
-
A
-
D
----
R
I
A
V
M
K
Q
G
R
I
L
QTASP
H
E
L
Y
R
------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
73.80
32%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-230]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
-
N
---
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-
L
-
P
V
R
----------
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
----
G
---
L
G
N
G
K
G
R
T
A
Q
E
R
-
Q
R
I
E
A
M
L
----
E
L
T
--
G
I
----
S
E
L
-------
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
-
A
-
D
----
R
I
A
V
M
K
Q
G
R
I
L
-----
Q
T
A
S
P
H
E
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.94
42%
25
- C1 -
1L2T
4
Y796_METJA
A:
[1-226]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
----
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
-
E
R
R
K
R
A
L
----
E
C
L
--
K
M
A
ELE
E
R
F
-------
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
-
A
-
R
F
-
G
-
E
----
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
---------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
72.89
33%
-99
- C1 -
2YYZ
3
?
A:
[2-220]
--
P
S
I
R
V
V
N
L
K
K
Y
F
G
-
K
---
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
N
D
I
P
P
------
K
----------
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
-
F
----
P
---
L
R
A
R
R
I
S
K
D
E
V
E
-
K
R
V
V
E
I
A
----
R
K
L
--
L
I
----
D
N
L
-------
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
-
T
M
-
A
-
S
----
R
I
A
V
F
N
Q
G
K
L
V
-----
Q
Y
G
T
P
D
E
----------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
72.08
33%
-11
- C1 -
1B0U
4
HISP_SALTY
A:
[5-241]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
-
G
---
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
-
L
V
R
D
K
D
G
Q
L
K
VAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
----
P
---
I
Q
V
L
G
L
S
K
H
D
A
R
-
E
R
A
L
K
Y
L
----
A
K
V
--
G
I
D---
E
R
A
-------
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
-
A
-
R
H
-
V
S
S
----
H
V
I
F
L
H
Q
G
K
I
E
-----
E
E
---
G
D
P
E
Q
V
F
-----------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.01
30%
-104
- C1 -
1Z47
1
?
A:
[15-224]
----
I
E
F
V
G
V
E
K
I
Y
P
-
G
--
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
V
T
D
L
P
P
Q
----------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
-
F
----
G
---
L
R
E
K
R
V
P
K
D
E
M
D
-
A
R
V
R
E
L
L
----
R
F
M
--
R
L
----
E
S
Y
-------
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
-
A
L
E
V
-
A
-
D
----
R
V
L
V
L
H
E
G
N
V
-----------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.40
42%
24
- C1 -
3TIF
7
Y796_METJA
B:
[1-226]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
----
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
-
E
R
R
K
R
A
L
----
E
C
L
--
K
M
AELE
E
R
F
-------
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
-
A
-
R
F
-
G
-
E
----
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
---------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
69.91
33%
-108
- C1 -
1OXX
21
?
K:
[3-227]
---
R
I
I
V
K
N
V
S
K
V
F
K
-
K
G
-
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
-
P
P
E
----------
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
----
P
---
L
T
N
M
K
M
S
K
E
E
I
R
-
K
R
V
E
E
V
A
----
K
I
L
--
D
I
----
H
H
V
-------
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
-
A
I
-
A
-
D
----
R
V
G
V
L
V
K
G
K
L
V
-----
Q
V
G
K
P
E
D
----------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.43
42%
30
- C1 -
1L2T
4
Y796_METJA
B:
[1-226]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
----------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
----
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
-
E
R
R
K
R
A
L
----
E
C
L
--
K
M
AELE
E
R
F
-------
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
-
A
-
R
F
-
G
-
E
----
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
---------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.40
36%
-85
- C1 -
2D62
7
?
A:
[6-221]
-----
E
V
K
L
I
N
-
I
W
K
-
R
F
G
D
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
A
D
P
E
K
G
V
F
V
P
P
K
----------
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
-
F
----
P
---
L
K
L
R
K
V
P
K
Q
E
I
D
-
K
R
V
R
E
V
A
----
E
M
L
--
G
L
----
T
E
L
-------
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
-
A
M
T
M
-
G
-
D
----
R
I
A
V
M
N
K
G
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.80
31%
-10
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-566]
----
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
--------------
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
GR--
P
---
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
----
M
N
L
PQ
G
Y
----
D
T
E
-------
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
-
I
-
T
H
-
A
-
D
----
K
I
V
V
I
E
N
G
H
I
--------
V
E
T
G
T
H
R
E
L
I
A
K
Q
--------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.19
31%
-10
- C1 -
2ONJ
4
Y1866_STAAM
B:
[340-566]
----
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
--------------
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
GR--
P
---
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
----
M
N
L
PQ
G
Y
----
D
T
E
-------
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
-
I
-
T
H
-
A
-
D
----
K
I
V
V
I
E
N
G
H
I
--------
V
E
T
G
T
H
R
E
L
I
A
K
Q
--------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
60.04
31%
-9
- C1 -
2ONJ
4
Y1866_STAAM
A:
[340-566]
----
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
--------------
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
GR--
P
---
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
----
M
N
L
PQ
G
Y
----
D
T
E
-------
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
-
I
-
T
H
-
A
-
D
----
K
I
V
V
I
E
N
G
H
I
--------
V
E
T
G
T
H
R
E
L
I
A
K
Q
--------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.91
34%
-59
- C1 -
3C41
3
?
J:
[2-219]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A---
P
---
M
K
V
R
K
W
P
R
E
K
A
E
-
A
K
A
M
E
L
L
----
D
K
V
--
G
L
----
K
D
K
-------
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
----
M
-
G
F
-
A
-
R
EVGD
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
---------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
59.90
31%
-10
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-566]
----
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
--------------
R
N
Q
I
G
L
V
Q
Q
D
-
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
GR--
P
---
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
----
M
N
L
PQ
G
Y
----
D
T
E
-------
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
-
I
-
T
H
-
A
-
D
----
K
I
V
V
I
E
N
G
H
I
--------
V
E
T
G
T
H
R
E
L
I
A
K
Q
--------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.03
34%
-58
- C1 -
3C41
3
?
K:
[2-219]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A---
P
---
M
K
V
R
K
W
P
R
E
K
A
E
-
A
K
A
M
E
L
L
----
D
K
V
--
G
L
----
K
D
K
-------
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
----
M
-
G
F
-
A
-
R
EVGD
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
---------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.24
31%
-66
- C1 -
1MV5
3
LMRA_LACLA
A:
[1-215]
---
M
L
S
A
R
H
V
D
F
A
Y
D
-
D
--
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
---
I
D
N
I
S
L
E
N
W
R
-----------
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
-
Y
----
G
---
L
E
G
D
Y
T
D
E
D
L
W
Q
--
V
L
D
L
A
F
----
A
R
S
--
F
V
----
E
N
M
PDQLN
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
--
T
T
L
V
I
A
H
R
L
S
T
-
I
-
V
D
-
A
-
D
----
K
I
Y
F
I
E
K
G
Q
I
-----------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
53.99
31%
-63
- C1 -
1MV5
2
LMRA_LACLA
B:
[1-215]
---
M
L
S
A
R
H
V
D
F
A
Y
D
-
D
--
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
---
I
D
N
I
S
L
E
N
W
R
-----------
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
-
Y
----
G
---
L
E
G
D
Y
T
D
E
D
L
W
Q
--
V
L
D
L
A
F
----
A
R
S
--
F
V
----
E
N
M
PDQLNTE
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
--
T
T
L
V
I
A
H
R
L
S
T
-
I
-
V
D
-
A
-
D
----
K
I
Y
F
I
E
K
G
Q
I
-----------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
50.85
32%
-58
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[342-540]
----
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
--------------
R
S
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
-
Y
GADD
P
---
S
S
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
--
G
F
----
N
T
V
-------
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
46.05
33%
-31
- C1 -
4S0F
2
?
B:
[504-701]
----------------------
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
---
H
S
I
K
N
I
S
L
-
E
L
I
----------
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
-
T
V
K
E
N
L
C
-
L
----
G
NEN
V
D
M
D
E
I
I
K
A
A
K
M
-
A
N
A
H
D
F
I
----
E
K
L
--
P
L
KY--
D
T
F
-------
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
-
I
-
V
N
-
C
-
D
----
K
I
Y
L
L
K
D
G
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------