@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0820: (2016-04-26 )
MAKRLDLTDVNIYYGSFHAVADVSLAILPRSVTAFIGPSGCGKTTVLRTLNRMHEVIPGARVEGAVLLDDQDIYAPGIDPVGVRRAIGMVFQRPNPFPAMSIRNNVVAGLKLQGVRNRKVLDDTAESSLRGANLWDEVKDRLDKPGGGLSGGQQQRLCIARAIAVQPDVLLMDEPCSSLDPISTMAIEDLISELKQQYTIVIVTHNMQQAARVSDQTAFFNLEAVGKPGRLVEIASTEKIFSNPNQKATEDYISGRFG
Atome Classification :
(35 SA)
.........10....----....20.-.......30........40........50------.........-60........70------------...-.----.....80--..-------...-....90....--....100......-..110......-...120.----......130......--------.--140......----------.150.......160...-....170.......180.......190....--.--.--.200.......210.......220.......230.......240...--....250......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKRLDL
T
D
V
N
I
Y
YG----
S
F
H
A
V
A
D
-
V
S
L
A
ILPR
S
V
T
A
FIGPSGC
G
K
T
T
V
L
R
T
L
-------
N
R
M
H
E
VIPG-ARV
E
G
A
V
L
LDD-------------QDI-Y----APGI
D
P
---
V
G
-------
V
R
R
-
A
I
G
M
V
FQRPN--PFP
A
M
S
-
I
RNN
V
V
-A
G
L
--
K
L
QGVR-NRKVLDD----T
A
E
SSLRGAN
L
W
D
E
V
--------
K
--
D
R
LDKPGGG----------LSGG
Q
Q
Q
R
L
C
I
A
R
A
IAV-QP
D
V
L
L
MDEPCSSLDP
I
S
T
M
A
I
E
D
L
I
S
E
L
K
Q--Q--
Y
--
T
I
V
I
V
TH
N
M
Q
Q
A
ARVSDQ
T
A
F
F
N
L
E
AVGKPG
R
L
V
E
IA
S
T
E
K
I
FSNPN--
Q
K
A
T
E
D
Y
ISGRFG--
3
PsiBlast_PDB
91.16
33%
-101
- C1 -
2OLJ
4
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
24
PsiBlast_CBE
90.62
33%
-106
- C1 -
3C4J
4
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
27
PsiBlast_CBE
90.16
33%
-97
- C1 -
2OUK
1
?
C:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
30
PsiBlast_CBE
89.85
33%
-102
- C1 -
2OLK
1
?
C:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
29
PsiBlast_CBE
89.83
33%
-103
- C1 -
2OLK
1
?
D:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
5
PsiBlast_PDB
89.81
33%
-102
- C1 -
2OUK
1
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
31
PsiBlast_CBE
88.83
33%
-102
- C1 -
2OLK
2
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
32
PsiBlast_CBE
88.81
33%
-100
- C1 -
2OLJ
3
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
7
PsiBlast_PDB
88.13
33%
-100
- C1 -
3C4J
3
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
33
PsiBlast_CBE
87.66
33%
-107
- C1 -
3C41
3
?
K:
[4-242]
----
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
8
PsiBlast_PDB
87.48
33%
-102
- C1 -
3C41
3
?
J:
[4-242]
----
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
4
PsiBlast_PDB
87.48
33%
-99
- C1 -
2OLK
1
?
A:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
6
PsiBlast_PDB
87.13
33%
-97
- C1 -
2Q0H
4
?
A:
[23-263]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
9
PsiBlast_PDB
87.00
34%
-108
- C1 -
4YMS
-
?
J:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
28
PsiBlast_CBE
86.96
33%
-100
- C1 -
2OUK
2
?
B:
[23-263]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
26
PsiBlast_CBE
86.92
33%
-98
- C1 -
2OUK
2
?
D:
[23-263]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
98
HHSearch
86.46
32%
-103
- C1 -
4FWI
3
?
B:
[2-265]
-
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
VREG
T
I
K
A
A
D
G
-
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
-------
T
K
T
L
P
P
N
G
R
--
I
L
S
G
R
V
L
Y
K
G
-------------
K
D
L
-
L
----
T
--
M
R
E
---
E
E
LRKI---
R
W
K
-
E
I
A
L
V
P
Q
A
A
Q
QS
L
N
P
T
M
K
-
V
I
E
H
F
K
-
D
T
V
--
E
A
H
G
V
R
W
S
H
S
E
L
I
E
----
K
A
S
E
K
L
R
M
V
R
L
N
P
----------
E
--
A
V
L
N
S
Y
P
L
Q
----------
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
-
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
ML
K
--
I
--
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
------
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
--
H
P
Y
T
R
G
L
I
-------
14
PsiBlast_PDB
85.77
34%
-112
- C1 -
1V43
-
?
A:
[15-249]
------
L
E
N
L
T
K
R
F
G
----
N
F
T
A
V
N
K
-
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
-------
A
G
L
E
E
------
P
T
E
G
R
I
Y
F
G
D
-------------
R
D
V
T
Y
----
L
P
P
K
D
---------------
R
-
N
I
S
M
V
F
Q
--------
H
M
T
-
V
Y
E
N
I
A
-
F
P
L
----------
K
K
F
P
K
D
----
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
--------
E
--
E
L
L
N
R
Y
P
A
Q
----------
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
--
K
--
L
KV
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
------
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
--
S
V
F
V
A
T
F
I
-------
13
PsiBlast_PDB
85.64
34%
-105
- C1 -
4YMW
-
?
J:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
11
PsiBlast_PDB
85.60
34%
-105
- C1 -
4YMU
2
?
J:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
12
PsiBlast_PDB
85.40
34%
-105
- C1 -
4YMV
1
?
J:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
34
PsiBlast_CBE
85.37
34%
-104
- C1 -
4YMV
1
?
A:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
35
PsiBlast_CBE
84.89
34%
-104
- C1 -
4YMU
2
?
A:
[4-237]
------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-
N
----
N
G
K
V
N
I
---
N
K
-------
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
--
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
--
K
V
K
K
M
--
N
K
K
E
A
E
E
----
L
A
V
D
L
L
A
K
V
G
L
L
D
--------------
K
K
D
Q
Y
P
I
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
------
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
------
25
PsiBlast_CBE
84.03
33%
-101
- C1 -
2Q0H
4
?
B:
[22-263]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
------
E
G
E
I
I
I
D
G
-------------
I
N
L
-
K
----
A
K
D
T
N
L
---
N
K
-------
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
--
L
F
P
H
M
T
-
V
L
N
N
I
T
-------
L
A
P
M
K
-
V
R
K
W
P
R
E
----
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL------
K
--
D
K
A
H
A
Y
P
D
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
------
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
---
1
PsiBlast_PDB
83.73
33%
-101
- C1 -
4U00
3
?
A:
[5-239]
----
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
L
K
G
-
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
-------------
R
A
L
-
R
----
E
-----------------
I
R
R
-
E
V
G
M
V
F
Q
Q
F
N
--
L
F
P
H
M
T
-
V
L
E
N
V
T
-------
L
A
P
M
R
-
V
R
R
W
P
R
E
----
K
A
E
K
--
K
A
L
E
L
L
E
R
V
--------
G
IL
D
Q
A
R
K
Y
P
A
Q
----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
--
E
E
R
T
R
S
F
L
Q
------
15
PsiBlast_PDB
83.47
34%
-107
- C1 -
1VCI
1
?
A:
[15-249]
------
L
E
N
L
T
K
R
F
G
----
N
F
T
A
V
N
K
-
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
-------
A
G
L
E
E
------
P
T
E
G
R
I
Y
F
G
D
-------------
R
D
V
T
Y
----
L
P
P
K
D
---------------
R
-
N
I
S
M
V
F
Q
--------
H
M
T
-
V
Y
E
N
I
A
-
F
P
L
----------
K
K
F
P
K
D
----
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
--------
E
--
E
L
L
N
R
Y
P
A
Q
----------
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
--
K
--
L
KV
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
------
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
--
S
V
F
V
A
T
F
I
-------
48
PsiBlast_CBE
77.49
31%
-97
- C1 -
1B0U
4
HISP_SALTY
A:
[6-255]
---
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
H
E
V
L
K
G
-
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
-------
N
F
L
E
K
--
P
S
----
E
G
A
I
I
V
N
G
-------------
Q
N
I
-
N
L
V
R
D
K
D
G
Q
L
K
---
V
A
D
K
N
Q
L
R
L
L
R
T
-
R
L
T
M
V
F
Q
H
F
N
--
L
W
S
H
M
T
-
V
L
E
N
V
M
E
A
P
I
--
Q
V
L
G
L
S
-
K
H
----
D
----
A
R
E
R
A
L
K
Y
L
-----
A
--------
K
--
V
G
I
D
E
R
A
Q
G
KYPVH-----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
--
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
------
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
--
S
P
R
L
Q
Q
F
L
K
G
-----
77
Fugue
74.06
33%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
H
E
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
FLEKPS-------------
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
-
D
----
K
N
Q
L
R
L
---
L
R
-------
T
-
R
--
L
T
M
V
F
Q
H
F
N
--
L
W
S
H
M
T
-
V
L
E
N
V
M
-
E
A
P
--
I
Q
V
L
----------GLS-
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
GIDERAQG-------
K
Y
P
V
H
----------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
--
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
------
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-QS
P
R
L
Q
Q
F
L
K
G
S
L
K
K
LE
72
PsiBlast_CBE
61.79
31%
-113
- C1 -
3TIF
6
Y796_METJA
B:
[19-218]
---------------------
Y
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-------
G
C
L
D
K
P
------
T
E
G
E
V
Y
I
D
N
---------------
I
-
K
----
T
N
D
L
D
D
DEL
T
K
-------
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
--
L
I
P
L
L
T
-
A
L
E
N
V
E
-
L
P
L
IF
K
Y
R
G
A
M
-
S
G
E
E
R
R
K
----
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--------
A
--
N
H
--
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------------------------------------------
70
PsiBlast_CBE
60.74
31%
-109
- C1 -
1L2T
4
Y796_METJA
B:
[18-218]
--------------------
I
Y
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-------
G
C
L
D
K
P
------
T
E
G
E
V
Y
I
D
N
---------------
I
-
K
----
T
N
D
L
D
D
DEL
T
K
-------
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
--
L
I
P
L
L
T
-
A
L
E
N
V
E
-
L
P
L
IF
K
Y
R
G
A
M
-
S
G
E
E
R
R
K
----
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--------
A
--
N
H
--
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------------------------------------------
71
PsiBlast_CBE
60.14
31%
-108
- C1 -
1L2T
4
Y796_METJA
A:
[18-218]
--------------------
I
Y
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-------
G
C
L
D
K
P
------
T
E
G
E
V
Y
I
D
N
---------------
I
-
K
----
T
N
D
L
D
D
D
E
L
T
K
-------
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
--
L
I
P
L
L
T
-
A
L
E
N
V
E
-
L
P
L
IF
K
Y
R
G
A
M
-
S
G
E
E
R
R
K
----
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--------
A
--
N
H
--
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------------------------------------------
73
PsiBlast_CBE
59.51
31%
-105
- C1 -
3TIF
7
Y796_METJA
A:
[19-218]
---------------------
Y
A
L
K
N
-
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-------
G
C
L
D
K
P
------
T
E
G
E
V
Y
I
D
N
---------------
I
-
K
----
T
N
D
L
D
D
D
E
L
T
K
-------
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
--
L
I
P
L
L
T
-
A
L
E
N
V
E
-
L
P
L
IF
K
Y
R
G
A
M
-
S
G
E
E
R
R
K
----
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--------
A
--
N
H
--
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
DG
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------------------------------------------
45
PsiBlast_CBE
58.26
33%
-85
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[362-573]
-------------------------
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
--
P
A
-
S
---
G
T
I
S
L
D
G
-------------
H
D
I
-
R
----
Q
--
L
N
P
---
V
W
-------
L
R
S
-
K
I
G
T
V
S
Q
E
P
I
--
L
F
-
S
C
S
-
I
A
E
N
I
A
-
Y
G
A
--------------
D
D
PSSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
--------
A
--
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
--
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
-------
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
-----------------
46
PsiBlast_CBE
54.77
33%
-82
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[362-567]
-------------------------
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
--
P
A
-
S
---
G
T
I
S
L
D
G
-------------
H
D
I
-
R
----
Q
--
L
N
P
---
V
W
-------
L
R
S
-
K
I
G
T
V
S
Q
E
P
I
--
L
F
-
S
C
S
-
I
A
E
N
I
A
-
Y
G
A
--------------
D
D
PSSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
--------
A
--
F
I
R
N
F
P
Q
G
F
NTVVGEKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
--
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
-------
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
44
PsiBlast_CBE
53.83
33%
-81
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[393-598]
-------------------------
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
--
P
A
-
S
---
G
T
I
S
L
D
G
-------------
H
D
I
-
R
----
Q
--
L
N
P
---
V
W
-------
L
R
S
-
K
I
G
T
V
S
Q
E
P
I
--
L
F
-
S
C
S
-
I
A
E
N
I
A
-
Y
G
A
--------------
D
D
PSSV
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
--------
A
--
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
EKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
--
R
--
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
-------
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------