@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0952: (2016-04-27 )
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL
Atome Classification :
(22 SA)
.........10......-..20........30........40........50........60........70........80........90........100.......110.......120.......130.......140...-....150.......160.......170.......180.--...--.....190.......200.......210.......220.......230...----..----..240.......250.......260.......270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
H
M
S
I
F
L
SRD
N
K
V
I
V
Q
-GITGSE
A
T
V
H
T
A
R
M
L
R
AGT
Q
I
VGGVNARKAGTTVTHEDKG
G
R
L
I
K
LPVF
G
S
V
A
E
A
M
E
KTGA
D
V
S
I
I
FVPPT
F
A
K
D
A
I
I
E
A
IDAEI
P
L
L
V
V
I
TEGIPVQDT
A
Y
A
W
A
Y
NLEAGHK
T
R
IIGPNCPGIISPG-QSLAGITPANITGPGPI
G
L
VSKSG
T
L
T
Y
Q
M
M
F
E
L
R
--D--LGF--STAIGIGGDPVIGT
T
H
I
D
A
I
E
A
F
ERDPD
T
K
L
I
V
M
I
GEIGG
D
A
E
E
R
A
A
D
F
I
K
----
T
N----VSKP
V
V
G
Y
VAGFTAPEGKTMGHA
G
A
I
VSGSSGT
A
A
A
K
Q
E
A
L
E
A
AGVKVGKTP
S
A
T
A
A
L
A
R
E
I
L
LSL
29
HHSearch
96.34
50%
-107
- C3 -
2NU8
4
SUCD_ECOLI
A:
[2-287]
-----
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
--
E
A
G
V
R
M
I
G
P
N
T
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
--
F
G
Q
--
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
----
A
E
E
E
A
A
A
Y
I
K
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
---
5
PsiBlast_PDB
94.69
54%
-106
- C3 -
2NUA
4
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
V
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
26
PsiBlast_CBE
94.18
54%
-105
- C3 -
2NUA
3
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
V
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
21
PsiBlast_CBE
93.90
54%
-101
- C3 -
1CQJ
2
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
23
PsiBlast_CBE
93.85
54%
-101
- C3 -
1SCU
2
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
6
PsiBlast_PDB
93.70
53%
-102
- C3 -
2NU7
4
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
S
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
7
PsiBlast_PDB
93.67
53%
-103
- C3 -
2NU8
4
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
T
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
25
PsiBlast_CBE
93.60
54%
-99
- C3 -
1JKJ
3
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
9
PsiBlast_PDB
93.54
50%
-119
- C3 -
2YV1
-
SUCD_METJA
A:
[8-292]
-----
I
L
L
D
E
N
T
K
A
I
V
Q
-
G
I
T
G
R
Q
G
S
F
H
T
K
K
M
L
E
C
G
T
K
I
V
G
G
V
T
P
G
K
G
G
Q
N
V
H
G
---------
V
P
V
F
D
T
V
K
E
A
V
K
E
T
D
A
N
A
S
V
I
F
V
P
A
P
F
A
K
D
A
V
F
E
A
I
D
A
G
I
E
L
I
V
V
I
T
E
H
I
P
V
H
D
T
M
E
F
V
N
Y
A
E
D
V
G
--
V
K
I
I
G
P
N
T
P
G
I
A
S
P
K
-
V
G
K
L
G
I
I
P
M
E
V
L
K
E
G
S
V
G
M
V
S
R
S
G
T
L
T
Y
E
I
A
H
Q
I
K
--
K
--
A
G
F
GV
S
T
C
V
G
I
G
G
D
P
I
V
G
L
R
Y
K
E
V
L
D
L
F
E
K
D
D
E
T
E
A
I
V
M
I
G
E
I
G
G
G
A
E
E
E
A
A
K
F
I
E
-----
K
----
M
K
K
P
V
I
G
Y
I
A
G
Q
-------------------
G
T
A
E
S
K
M
K
A
L
E
E
A
G
A
Y
V
A
K
N
I
S
D
I
P
K
L
L
A
G
I
L
---
2
PsiBlast_PDB
93.53
54%
-101
- C3 -
1CQJ
2
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
24
PsiBlast_CBE
93.27
54%
-99
- C3 -
1JLL
3
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
4
PsiBlast_PDB
93.21
54%
-98
- C3 -
1JLL
3
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
27
PsiBlast_CBE
93.04
53%
-102
- C3 -
2NU7
4
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
S
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
3
PsiBlast_PDB
92.95
54%
-99
- C3 -
1JKJ
6
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
--
H
-------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
28
PsiBlast_CBE
92.86
53%
-102
- C3 -
2NU8
3
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
T
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
22
PsiBlast_CBE
92.28
54%
-102
- C3 -
1CQI
2
SUCD_ECOLI
D:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
14
PsiBlast_PDB
92.24
45%
-110
- C3 -
3UFX
-
SUCD_THETH
A:
[2-287]
-----
I
L
V
N
K
E
T
R
V
L
V
Q
-
G
I
T
G
R
E
G
Q
F
H
T
K
Q
M
L
S
Y
G
T
K
I
V
A
G
V
T
P
G
K
G
G
M
E
V
---------
L
G
V
P
V
Y
D
T
V
K
E
A
V
A
H
H
E
V
D
A
S
I
I
F
V
P
A
P
A
A
A
D
A
A
L
E
A
A
H
A
G
I
P
L
I
V
L
I
T
E
G
I
P
T
L
D
M
V
R
A
V
E
E
I
K
A
L
G
--
S
R
L
I
G
G
N
C
P
G
I
I
S
A
E
-
E
T
K
I
G
I
M
P
G
H
V
F
K
R
G
R
V
G
I
I
S
R
S
G
T
L
T
Y
E
A
A
A
A
L
S
--
Q
A
G
L
G
T
--
T
T
T
V
G
I
G
G
D
P
V
I
G
T
T
F
K
D
L
L
P
L
F
N
E
D
P
E
T
E
A
V
V
L
I
G
E
I
G
G
S
D
E
E
E
A
A
A
W
V
K
----
D
H
----
M
K
K
P
V
V
G
F
I
G
G
R
S
A
P
K
G
K
R
M
G
H
A
G
A
I
I
M
G
N
V
G
T
P
E
S
K
L
R
A
F
A
E
A
G
I
P
V
A
D
T
I
D
E
I
V
E
L
V
K
K
A
L
---
1
PsiBlast_PDB
91.78
54%
-101
- C3 -
1CQI
2
SUCD_ECOLI
A:
[1-271]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
---------
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
-
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
--
D
--
Y
G
F
GQ
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
----
E
H
----
V
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
-------------------
13
PsiBlast_PDB
91.35
45%
-115
- C3 -
1OI7
-
SUCD_THETH
A:
[2-287]
-----
I
L
V
N
R
E
T
R
V
L
V
Q
-
G
I
T
G
R
E
G
Q
F
H
T
K
Q
M
L
T
Y
G
T
K
I
V
A
G
V
T
P
G
K
G
G
M
E
V
---------
L
G
V
P
V
Y
D
T
V
K
E
A
V
A
H
H
E
V
D
A
S
I
I
F
V
P
A
P
A
A
A
D
A
A
L
E
A
A
H
A
G
I
P
L
I
V
L
I
T
E
G
I
P
T
L
D
M
V
R
A
V
E
E
I
K
A
L
G
--
S
R
L
I
G
G
N
C
P
G
I
I
S
A
E
-
E
T
K
I
G
I
M
P
G
H
V
F
K
R
G
R
V
G
I
I
S
R
S
G
T
L
T
Y
E
A
A
A
A
L
S
--
Q
A
G
L
G
T
--
T
T
T
V
G
I
G
G
D
P
V
I
G
T
T
F
K
D
L
L
P
L
F
N
E
D
P
E
T
E
A
V
V
L
I
G
E
I
G
G
S
D
E
E
E
A
A
A
W
V
K
----
D
H
----
M
K
K
P
V
V
G
F
I
G
G
R
------------------
V
G
T
P
E
S
K
L
R
A
F
A
E
A
G
I
P
V
A
D
T
I
D
E
I
V
E
L
V
K
K
A
L
---
33
HHSearch
91.33
49%
-116
- C3 -
2YV1
-
SUCD_METJA
A:
[7-293]
----
M
I
L
L
D
E
-
N
T
K
A
I
V
Q
G
I
T
G
R
Q
G
S
F
H
T
K
K
M
L
E
C
G
T
K
I
V
G
G
V
T
P
G
K
G
G
Q
N
---------
V
H
G
V
P
V
F
D
T
V
K
E
A
V
K
E
T
D
A
N
A
S
V
I
F
V
P
A
P
F
A
K
D
A
V
F
E
A
I
D
A
G
I
E
L
I
V
V
I
T
E
H
I
P
V
H
D
T
M
E
F
V
N
Y
A
E
--
D
V
G
V
K
I
I
G
P
N
T
P
G
I
A
S
P
K
V
G
K
L
-
G
I
I
P
M
E
V
L
K
E
G
S
V
G
M
V
S
R
S
G
T
L
T
Y
E
I
A
H
Q
I
K
K
A
G
--
F
G
V
--
S
T
C
V
G
I
G
G
D
P
I
V
G
L
R
Y
K
E
V
L
D
L
F
E
K
D
D
E
T
E
A
I
V
M
I
G
E
I
G
G
G
A
E
E
E
A
A
K
F
I
E
-----
K
----
M
K
K
P
V
I
G
Y
I
A
G
Q
-------------------
G
T
A
E
S
K
M
K
A
L
E
E
A
G
A
Y
V
A
K
N
I
S
D
I
P
K
L
L
A
G
I
L
G
--
12
PsiBlast_PDB
88.48
48%
-98
- C3 -
4XX0
7
SUCA_PIG
A:
[9-289]
-----
L
Y
V
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
K
Q
G
T
F
H
S
Q
Q
A
L
E
Y
G
T
N
L
V
--
G
G
T
T
P
G
K
G
G
K
T
H
-------
L
G
L
P
V
F
N
T
V
K
E
A
K
E
Q
T
G
A
T
A
S
V
I
Y
V
P
P
P
F
A
A
A
A
I
N
E
A
I
D
A
E
V
P
L
V
V
C
I
T
E
G
I
P
Q
Q
D
M
V
R
V
K
H
R
L
L
R
Q
G
-
K
T
R
L
I
G
P
N
C
P
G
V
I
N
P
G
-
E
C
K
I
G
I
M
P
G
H
I
H
K
K
G
R
I
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
H
Q
T
T
--
Q
V
G
L
G
Q
--
S
L
C
V
G
I
G
G
D
P
F
N
G
T
D
F
T
D
C
L
E
I
F
L
N
D
P
A
T
E
G
I
I
L
I
G
E
I
G
G
N
A
E
E
N
A
A
E
F
L
K
----
Q
H
NSGP
K
S
K
P
V
V
S
F
I
A
G
L
T
A
P
P
G
R
R
M
G
H
A
G
A
I
I
A
G
G
K
G
G
A
K
E
K
I
T
A
L
Q
S
A
G
V
V
V
S
M
S
P
A
-------------
53
Fugue
57.47
50%
-114
* C3 *
2SCU
1
SUCD_ECOLI
A:
[1-119]
----
S
I
L
I
D
K
N
T
K
V
I
C
Q
-
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
---------
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
G
--
V
R
M
I
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------