@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1380: (2016-05-01 )
MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGRTVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRIVIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADAVLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVADSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA
Atome Classification :
(63 SA)
.........10........20........30........40---........50........60........70......-.-.80....-....90........100.......110.......120.......130.......140.......150.......160.......170.......180...-....190.....-..200.------.------.--------.------.--...210....-----...220.......230.......240-.-------......-250....-...260-.......270.......280.......290.......300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTPR
H
L
L
T
A
ADLSRD
D
A
T
A
I
LD
D
A
D
R
F
A
Q
A
L
V
G
R
D
I
K
KLPT---LRG
R
T
V
V
T
M
F
YENST
R
T
R
V
S
F
E
V
AGKWMS
A
D
V
I
N
V
S-A-AGSSVGK-GESLR
D
T
A
L
T
L
RAAGA
D
A
L
I
I
RHPAS
G
A
A
H
L
L
A
Q
W
TGAHNDGP
A
V
I
NAGDGTHEH
P
T
Q
A
L
L
D
A
L
T
I
R
Q
R
LGGIEG
R
R
I
V
I
V
G
D
I
L
H
S
R
V
ARS
N
V
M
L
L
DTL-G
A
E
V
V
L
VAPP
T
L
-
L
P
VG-V------T------G--------W------P--ATVSHDFDAE-----LPAA
D
A
V
L
M
L
R
V
Q
A
E
RMNGGFFP
S
V
R
-
E
-------
Y
S
V
RYG-
L
T
E
R
R
Q
A-MLPG
H
A
-
V
V
LHPGP
M
V
R
G
M
E
I
T
S
S
VAD
S
S
Q
S
A
V
L
Q
Q
V
SN
G
V
Q
V
R
M
A
V
L
F
H
V
L
VGAQDAGKEGAA
3
PsiBlast_PDB
96.56
37%
-108
- C7 -
3R7F
7
PYRB_BACSU
A:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
27
PsiBlast_CBE
95.91
37%
-109
- C7 -
3R7F
8
PYRB_BACSU
B:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
26
PsiBlast_CBE
95.55
37%
-105
- C7 -
3R7F
7
PYRB_BACSU
C:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
111
HHSearch
95.14
37%
-103
- C7 -
3R7F
7
PYRB_BACSU
A:
[1-291]
--
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
------
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
-----
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
Q
D
E
E
N
-
T
--------------------------------
F
G
T
Y
V
S
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
R
M
K
-
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----------
21
PsiBlast_CBE
95.04
37%
-106
- C7 -
3R7L
3
PYRB_BACSU
F:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
25
PsiBlast_CBE
93.99
37%
-105
- C7 -
3R7L
3
PYRB_BACSU
B:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
28
PsiBlast_CBE
93.93
37%
-106
- C7 -
3R7D
4
PYRB_BACSU
C:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
2
PsiBlast_PDB
93.71
37%
-104
- C7 -
3R7D
3
PYRB_BACSU
A:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
4
PsiBlast_PDB
93.65
37%
-104
- C7 -
3R7L
3
PYRB_BACSU
A:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
24
PsiBlast_CBE
93.49
37%
-106
- C7 -
3R7L
3
PYRB_BACSU
C:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
22
PsiBlast_CBE
93.47
37%
-104
- C7 -
3R7L
3
PYRB_BACSU
E:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
23
PsiBlast_CBE
93.32
37%
-104
- C7 -
3R7L
3
PYRB_BACSU
D:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
29
PsiBlast_CBE
92.91
37%
-107
- C7 -
3R7D
2
PYRB_BACSU
B:
[2-285]
---
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
------
K
T
D
N
Q
---
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
-
G
-
T
S
T
S
V
Q
K
-
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
-----
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
E
-
N
------
T
---------------
F
------
G
--
T
Y
V
S
--
M
D
E
A
-----
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
-
G
-------
Y
L
N
K
Y
G
-
L
T
V
E
R
A
E
-
R
M
K
R
H
A
-
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
----------------
10
PsiBlast_PDB
92.34
34%
-119
- C7 -
1ML4
1
PYRB_PYRAB
A:
[6-305]
---
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
--
K
E
K
G
Q
L
E
Y
---
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
-
S
T
S
S
V
K
K
-
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
A
R
L
A
A
E
V
A
E
V
-----
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
P
R
H
-
I
------
V
E
E
L
R
E
K
G
--------
M
------
K
--
V
V
E
T
T
T
L
E
D
V
-----
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
E
Q
-
E
Y
L
K
V
KGS
Y
Q
V
N
L
K
-
V
L
E
K
A
K
D
-
E
L
R
-----
I
M
H
P
L
P
R
V
D
--
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
------------
5
PsiBlast_PDB
89.13
35%
-105
- C7 -
3D6N
1
PYRB_AQUAE
B:
[2-285]
---
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
-------
K
E
E
T
---
I
K
A
-
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
S
-
G
-
S
E
S
S
T
V
K
-
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
--
K
E
I
V
K
S
L
N
--
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
-
I
P
R
D
-
V
------
E
------
V
--------
F
------
K
--
V
D
V
F
D
D
V
D
K
G
-----
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
-
S
-------
Y
F
K
Q
F
G
-
L
T
K
E
R
F
E
-
K
V
---
K
-
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------------
33
PsiBlast_CBE
88.94
34%
-102
- C7 -
3E2P
1
PYRB_METJA
K:
[2-296]
---
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
N
T
K
--
R
P
L
K
L
---
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
A
K
-
G
E
S
L
I
D
T
I
R
V
I
-
S
G
Y
A
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
A
S
E
Y
S
Q
V
-----
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
P
K
D
I
I
------
E
------
D
--------
L
------
K
--
A
K
N
I
K
F
Y
E
K
E
SLDDL
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
P
N
-
E
-------
Y
E
K
V
K
G
-
S
Y
K
I
K
R
E
-
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
R
V
D
--
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
----------------
41
PsiBlast_CBE
88.45
34%
-103
- C7 -
2RGW
1
PYRB_METJA
F:
[2-296]
---
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
N
T
K
--
R
P
L
K
L
---
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
A
K
-
G
E
S
L
I
D
T
I
R
V
I
-
S
G
Y
A
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
A
S
E
Y
S
Q
V
-----
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
P
K
D
I
I
------
E
------
D
--------
L
------
K
--
A
K
N
I
K
F
Y
E
K
E
SLDDL
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
P
N
-
E
-------
Y
E
K
V
K
G
-
S
Y
K
I
K
R
E
-
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
R
V
D
--
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
----------------
8
PsiBlast_PDB
88.27
34%
-101
- C7 -
3E2P
1
PYRB_METJA
A:
[2-296]
---
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
N
T
K
--
R
P
L
K
L
---
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
A
K
-
G
E
S
L
I
D
T
I
R
V
I
-
S
G
Y
A
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
A
S
E
Y
S
Q
V
-----
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
P
K
D
I
I
------
E
------
D
--------
L
------
K
--
A
K
N
I
K
F
Y
E
K
E
SLDDL
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
P
N
-
E
-------
Y
E
K
V
K
G
-
S
Y
K
I
K
R
E
-
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
R
V
D
--
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
----------------
36
PsiBlast_CBE
88.13
34%
-100
- C7 -
3E2P
1
PYRB_METJA
F:
[2-296]
---
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
N
T
K
--
R
P
L
K
L
---
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
A
K
-
G
E
S
L
I
D
T
I
R
V
I
-
S
G
Y
A
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
A
S
E
Y
S
Q
V
-----
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
P
K
D
I
I
------
E
------
D
--------
L
------
K
--
A
K
N
I
K
F
Y
E
K
E
SLDDL
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
P
N
-
E
-------
Y
E
K
V
K
G
-
S
Y
K
I
K
R
E
-
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
R
V
D
--
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
----------------
30
PsiBlast_CBE
88.12
34%
-101
- C7 -
3E2P
1
PYRB_METJA
N:
[2-296]
---
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
N
T
K
--
R
P
L
K
L
---
L
E
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
A
K
-
G
E
S
L
I
D
T
I
R
V
I
-
S
G
Y
A
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
A
S
E
Y
S
Q
V
-----
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
P
K
D
I
I
------
E
------
D
--------
L
------
K
--
A
K
N
I
K
F
Y
E
K
E
SLDDL
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
P
N
-
E
-------
Y
E
K
V
K
G
-
S
Y
K
I
K
R
E
-
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
R
V
D
--
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
----------------
6
PsiBlast_PDB
87.97
35%
-104
- C7 -
4BJH
14
PYRB_AQUAE
B:
[33-316]
---
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
-------
K
E
E
T
---
I
K
A
-
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
S
-
G
-
S
E
S
S
T
V
K
-
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
--
K
E
I
V
K
S
L
N
--
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
-
I
P
R
D
-
V
------
E
------
V
--------
F
------
K
--
V
D
V
F
D
D
V
D
K
G
-----
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
-
S
-------
Y
F
K
Q
F
G
-
L
T
K
E
R
F
E
-
K
V
---
K
-
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------------
100
PsiBlast_CBE
87.66
31%
-108
- C7 -
3AT1
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
122
HHSearch
87.59
33%
-105
- C7 -
1ML4
1
PYRB_PYRAB
A:
[3-307]
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
R
E
L
K
E
--
K
G
Q
L
E
Y
---
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
-
E
A
S
T
S
S
V
K
K
-
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
-----
A
A
R
L
A
A
E
V
A
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
P
R
H
-
I
------
V
------
E
E
L
R
E
----
K
------
G
MK
V
V
E
T
T
T
L
E
D
V
-----
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
--
E
Y
L
-
K
-------
V
K
G
S
Y
Q
-
V
N
L
K
V
L
E
K
A
K
-
D
E
L
-
R
I
M
H
P
L
P
R
V
--
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
----------
53
PsiBlast_CBE
86.24
31%
-103
- C7 -
4KGX
1
?
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
99
PsiBlast_CBE
86.21
31%
-105
- C7 -
3AT1
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
48
PsiBlast_CBE
86.11
31%
-105
- C7 -
4KH1
2
?
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
68
PsiBlast_CBE
86.04
31%
-105
- C7 -
2FZG
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
54
PsiBlast_CBE
85.87
31%
-105
- C7 -
4KGX
1
?
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
70
PsiBlast_CBE
85.84
31%
-105
- C7 -
2FZC
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
92
PsiBlast_CBE
85.78
31%
-105
- C7 -
1EKX
2
PYRB_ECOLI
A:
[8-305]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
58
PsiBlast_CBE
85.76
31%
-106
- C7 -
4F04
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
67
PsiBlast_CBE
85.69
31%
-104
- C7 -
2FZK
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
50
PsiBlast_CBE
85.69
31%
-107
- C7 -
4KH0
1
?
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
96
PsiBlast_CBE
85.61
31%
-102
- C7 -
8AT1
2
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
91
PsiBlast_CBE
85.48
31%
-106
- C7 -
1EKX
3
PYRB_ECOLI
B:
[8-305]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
98
PsiBlast_CBE
85.37
31%
-103
- C7 -
7AT1
2
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
56
PsiBlast_CBE
85.28
31%
-106
- C7 -
4KGV
1
?
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
73
PsiBlast_CBE
85.27
31%
-104
- C7 -
2AIR
2
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
11
PsiBlast_PDB
85.20
32%
-120
- C7 -
3LXM
1
PYRB_YERPE
A:
[32-329]
---
K
H
I
I
S
I
N
D
L
S
R
D
E
L
E
L
V
L
----
R
T
A
A
S
L
-----
K
K
T
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
I
H
R
L
G
A
S
V
V
G
F
S
D----------
G
E
T
L
A
D
T
-
M
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
S
R
L
A
A
Q
F
S
G
----
N
V
P
I
V
N
A
G
D
G
A
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
I
N
I
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
N
G
N
H
F
F
F
I
A
P
D
A
L
A
M
P
A
Y
-
I
------
L
------
Q
--------
M
L
E
E
K
E
I
E
--
Y
S
L
H
E
S
L
E
E
V
-----
V
P
E
L
D
I
L
Y
M
T
R
----------
Y
A
N
V
K
A
Q
-------
F
I
L
R
S
S
D
L
T
G
A
R
D
N
-
L
------
K
V
L
H
P
L
P
R
I
D
--
E
I
T
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
47
PsiBlast_CBE
85.13
31%
-102
- C7 -
4KH1
1
?
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
49
PsiBlast_CBE
84.91
31%
-105
- C7 -
4KH0
1
?
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
94
PsiBlast_CBE
84.86
31%
-101
- C7 -
8ATC
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
90
PsiBlast_CBE
84.83
31%
-104
- C7 -
1EKX
3
PYRB_ECOLI
C:
[8-305]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
75
PsiBlast_CBE
84.83
31%
-106
- C7 -
1ZA2
3
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
59
PsiBlast_CBE
84.73
31%
-104
- C7 -
4F04
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
55
PsiBlast_CBE
84.73
31%
-104
- C7 -
4KGV
1
?
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
69
PsiBlast_CBE
84.65
31%
-100
- C7 -
2FZG
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
64
PsiBlast_CBE
84.59
31%
-101
- C7 -
2H3E
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
66
PsiBlast_CBE
84.56
31%
-103
- C7 -
2FZK
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
62
PsiBlast_CBE
84.55
31%
-102
- C7 -
2IPO
4
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
93
PsiBlast_CBE
84.44
31%
-101
- C7 -
8ATC
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
76
PsiBlast_CBE
84.39
31%
-107
- C7 -
1R0C
2
PYRB_ECOLI
G:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
14
PsiBlast_PDB
84.14
31%
-101
- C7 -
1D09
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
71
PsiBlast_CBE
84.07
31%
-101
- C7 -
2FZC
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
65
PsiBlast_CBE
84.03
31%
-102
- C7 -
2H3E
1
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
46
PsiBlast_CBE
83.89
31%
-102
- C7 -
1D09
1
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
74
PsiBlast_CBE
83.85
31%
-104
- C7 -
1ZA2
2
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
63
PsiBlast_CBE
83.84
31%
-102
- C7 -
2IPO
2
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
77
PsiBlast_CBE
83.61
31%
-104
- C7 -
1R0C
2
PYRB_ECOLI
A:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
L
D
M
L
D
E
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
95
PsiBlast_CBE
83.40
31%
-101
- C7 -
8AT1
2
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
72
PsiBlast_CBE
83.34
31%
-101
- C7 -
2AIR
2
PYRB_ECOLI
G:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
Q
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
97
PsiBlast_CBE
83.04
31%
-101
- C7 -
7AT1
2
PYRB_ECOLI
C:
[7-304]
---
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
---------
L
K
A
N
P
Q
PEL
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
-
I
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
T
E
F
S
G
----
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
P
E
Y
-
I
LDMLDE
K
------
G
--------
I
------
A
--
W
S
L
H
S
S
I
E
E
V
-----
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
-------
F
V
L
R
A
S
-
D
L
H
N
A
K
A
-
N
M
K
-----
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------------
114
HHSearch
82.00
30%
-87
- C7 -
2I6U
5
OTC_MYCTU
A:
[2-306]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
----
S
R
R
P
L
---
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
-
S
-
G
S
T
Q
L
G
R
-
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
-
V
D
A
I
V
W
R
T
F
G
Q
E
-----
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
G
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
-
N
N
M
A
H
S
L
L
L
G
G
V
T
A
-
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
------
R
------
A
A
A
E
R
R
A
Q
D
T
------
G
A
S
V
T
V
T
A
D
A
H
A
A
-----
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
G
-
L
D
R
V
-
K
-------
P
F
R
P
F
Q
-
L
N
S
R
L
L
A
L
A
D
-
S
D
A
-
I
V
L
H
C
L
P
A
H
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
----------