@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2207: (2016-05-08 )
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP
Atome Classification :
(37 SA)
--.........10........20........30........40......-..50........60........70........80......-..90.-.......100.......110....-.-.-.120.--......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MIGFAPVST
P
D
A
A
A
E
A
A
A
R
A
RQDSLTKPRGALG
S
L
E
D
L
S
V
W
V
A
S
C
Q
Q-RCPP
R
Q
F
E
R
A
R
V
V
V
F
AGDHGVARSGVSAYP
P
E
V
T
A
Q
M
V
A
N-IDAG
G
-
A
A
I
N
A
L
A
D
VAG
A
T
V
R
V
A
D
L
AVDA
D
-
P
-
L
-
S
E
R
I
G
--
A
H
K
VRRGSGNIATEDALTNDE
T
A
A
A
I
TAGQ
Q
I
A
D
E
EVDAGA
D
L
L
I
A
GDMGIG
N
T
T
A
A
A
V
L
V
A
ALTDAE
P
V
A
V
V
G
FGTGIDDAGWA
R
K
T
A
A
V
R
D
A
L
F
R
VRPVLPDP
V
G
L
L
RCAGG
A
D
L
A
A
I
A
G
F
C
A
Q
A
A
V
RRT
P
L
L
LD
G
V
A
V
T
A
A
A
L
V
A
E
R
LAP
G
A
H
R
W
W
QAGHRSSEPGH
G
L
A
L
A
A
LGLD
P
I
V
D
L
H
M
RLGEG
T
G
A
A
V
A
L
M
V
L
R
A
A
V
A
A
L
S
S
M
A
T
F
T
EAGVSTRSVDGVDRTAPPAVSP
1
PsiBlast_PDB
96.86
49%
-88
- C10 -
1WX1
1
COBT_THET8
A:
[2-333]
------------
D
P
E
V
F
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
-
R
V
K
P
-
E
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
-
F
L
R
G
G
-
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
L
P
-
D
-
H
P
G
L
L
--
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
-----
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
R
L
H
P
G
M
-
G
P
L
E
V
A
A
E
V
G
G
L
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
-
A
R
I
L
H
M
A
T
F
Q
E
A
G
V
S
-----------------
58
HHSearch
96.69
49%
-87
- C10 -
1WX1
1
COBT_THET8
A:
[1-334]
-----------
M
D
P
E
V
F
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
-
R
V
K
P
E
-
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
-
F
L
R
G
G
-
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
-
L
P
D
-
H
P
G
L
L
--
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
-----
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
R
L
H
P
-
G
M
G
P
L
E
V
A
A
E
V
G
G
L
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
A
R
I
L
-
H
M
A
T
F
Q
E
A
G
V
S
R
----------------
2
PsiBlast_PDB
94.76
49%
-86
- C10 -
1J33
-
COBT_THET8
A:
[7-333]
-----------------
A
Q
A
R
L
R
M
D
Q
L
T
K
P
P
R
A
L
G
Y
L
E
E
V
A
L
R
L
A
A
L
Q
G
-
R
V
K
P
-
E
L
G
R
G
A
V
V
V
A
A
A
D
H
G
V
V
A
E
G
V
S
A
Y
P
Q
E
V
T
R
Q
M
V
L
N
-
F
L
R
G
G
-
A
A
I
N
Q
F
A
L
A
A
D
C
A
V
Y
V
L
D
V
G
V
V
G
E
L
P
-
D
-
H
P
G
L
L
--
K
R
K
V
R
P
G
T
A
N
L
A
Q
G
P
A
M
T
P
E
E
A
E
R
A
L
L
A
G
R
E
A
A
R
R
A
I
A
E
G
A
T
L
L
A
A
G
D
M
G
I
G
N
T
T
A
A
A
A
L
T
A
A
L
L
G
L
P
P
E
A
V
V
G
R
G
T
G
V
G
E
E
G
L
R
R
K
R
Q
A
V
A
R
A
L
A
R
L
H
P
G
M
-
G
P
L
E
V
A
A
E
V
G
G
I
E
L
V
A
I
A
G
I
Y
L
E
G
Y
E
A
G
L
P
L
V
L
D
G
F
P
V
T
A
G
A
L
L
A
W
K
M
A
P
G
L
R
D
H
L
F
A
G
H
L
S
R
E
P
G
H
R
H
Q
L
E
A
L
G
L
R
P
L
L
D
L
D
L
A
L
G
E
G
T
G
A
V
L
A
M
P
L
L
R
A
A
-
A
R
I
L
H
M
A
T
F
Q
E
A
G
V
S
-----------------
8
PsiBlast_PDB
91.67
35%
-88
- C10 -
4HDR
4
?
A:
[11-341]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
-
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
---
L
-
S
Y
V
P
G
LW
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
----
R
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
9
PsiBlast_PDB
91.44
35%
-86
- C10 -
4HDS
2
?
A:
[11-341]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
-
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
---
L
-
S
Y
V
P
G
LW
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
-----
S
R
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
3
PsiBlast_PDB
91.43
35%
-91
- C10 -
4KQJ
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
Y
P
K
I
V
T
A
I
M
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
M
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
4
PsiBlast_PDB
91.09
35%
-91
- C10 -
4KQK
7
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
Y
P
K
I
V
T
A
I
M
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
M
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
48
Fugue
91.04
33%
-87
- C10 -
1D0V
2
COBT_SALTY
A:
[4-349]
-L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
---
I
P
G
V
V
--
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
A
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
---------------
14
PsiBlast_PDB
90.97
34%
-91
- C10 -
1JHM
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
26
PsiBlast_CBE
90.93
34%
-89
- C10 -
1L5F
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
46
Fugue
90.69
33%
-87
- C10 -
1JHU
3
COBT_SALTY
A:
[4-349]
-L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
---
I
P
G
V
V
--
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
---------------
5
PsiBlast_PDB
90.57
35%
-86
- C10 -
4HDK
6
?
A:
[11-341]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
---
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
-
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
---
L
-
S
Y
V
P
G
LW
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
I
S
---
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
22
PsiBlast_CBE
90.52
34%
-89
- C10 -
1L5O
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
47
Fugue
90.50
33%
-86
- C10 -
1JH8
3
COBT_SALTY
A:
[3-350]
T
L
H
A
L
L
R
D
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
---
I
P
G
V
V
--
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
V
L
P
E
--------------
23
PsiBlast_CBE
90.50
34%
-89
- C10 -
1L5N
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
25
PsiBlast_CBE
90.45
34%
-91
- C10 -
1L5K
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
56
HHSearch
90.37
34%
-91
* C10 *
4KQI
3
COBT_SALTY
A:
[8-342]
-----
L
R
D
I
P
A
P
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
L
N
G
T
P
-
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
---
I
P
G
V
V
--
N
M
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
A
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
----------------------
17
PsiBlast_PDB
90.32
34%
-89
- C10 -
1JHQ
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
7
PsiBlast_PDB
90.32
35%
-86
- C10 -
4HDN
-
?
A:
[9-339]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
-
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
---
L
-
S
Y
V
P
G
LW
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
I
S
---
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
36
PsiBlast_CBE
90.27
34%
-89
- C10 -
1JHY
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
33
PsiBlast_CBE
90.23
34%
-91
- C10 -
1L4F
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
21
PsiBlast_CBE
90.20
35%
-89
- C10 -
4HDR
5
?
C:
[11-341]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
Y
L
I
S
Q
G
-
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
---
L
-
S
Y
V
P
G
LW
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
-------
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
57
HHSearch
90.14
34%
-88
- C10 -
4HDR
4
?
A:
[10-341]
-----
V
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
V
V
A
S
A
D
H
G
V
A
R
R
V
V
S
A
Y
P
I
E
T
T
I
H
M
T
A
N
-
Y
L
I
S
Q
G
A
S
A
N
A
F
A
N
F
C
G
A
D
M
V
V
V
D
M
G
V
A
G
D
-
L
-
S
Y
V
P
G
L
W
--
H
R
K
I
A
Y
G
T
Q
D
F
T
E
G
P
A
M
T
R
E
Q
A
I
Q
A
V
E
T
G
I
D
I
V
N
D
R
V
K
H
G
N
R
C
F
C
L
G
E
M
G
I
G
N
T
T
S
S
A
T
I
V
G
A
F
T
G
L
A
P
E
K
V
T
G
R
G
T
G
----
R
L
K
T
K
M
E
I
V
G
R
A
L
A
V
N
K
P
N
P
Q
D
G
L
D
V
L
A
K
V
G
G
F
E
L
G
A
L
A
G
V
I
L
G
S
A
A
N
R
C
A
V
V
I
D
G
L
N
T
T
A
A
A
L
I
A
N
V
I
H
P
L
S
K
E
Y
M
F
A
S
H
L
S
G
E
P
A
H
S
I
A
L
R
Q
L
Q
L
E
A
C
L
E
L
G
V
R
L
G
E
G
I
G
A
S
M
V
V
D
M
L
Y
V
A
I
K
L
L
N
N
---------------------------
15
PsiBlast_PDB
90.14
34%
-89
- C10 -
1JHO
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
32
PsiBlast_CBE
90.02
34%
-90
- C10 -
1L4G
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
28
PsiBlast_CBE
90.00
34%
-90
- C10 -
1L4M
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
29
PsiBlast_CBE
89.98
34%
-89
- C10 -
1L4L
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
19
PsiBlast_PDB
89.87
34%
-90
- C10 -
1JHV
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
11
PsiBlast_PDB
89.86
34%
-88
- C10 -
1D0V
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
A
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
30
PsiBlast_CBE
89.72
34%
-90
- C10 -
1L4K
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
31
PsiBlast_CBE
89.63
34%
-91
- C10 -
1L4H
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
34
PsiBlast_CBE
89.59
34%
-88
- C10 -
1L4E
1
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
13
PsiBlast_PDB
89.59
34%
-90
- C10 -
1JHA
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
39
PsiBlast_CBE
89.49
34%
-91
- C10 -
4KQI
3
COBT_SALTY
A:
[11-342]
--------
I
P
A
P
D
A
E
A
M
A
R
A
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
A
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
----------------------
27
PsiBlast_CBE
89.34
34%
-90
- C10 -
1L4N
3
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
24
PsiBlast_CBE
89.13
34%
-90
- C10 -
1L5L
2
COBT_SALTY
A:
[11-346]
--------
I
P
A
P
D
A
E
A
M
A
R
T
Q
Q
H
I
D
G
L
L
K
P
P
G
S
L
G
R
L
E
T
L
A
V
Q
L
A
G
M
P
G
-
L
N
G
T
P
Q
V
G
E
K
A
V
L
V
M
C
A
D
H
G
V
W
D
E
G
V
A
V
S
P
K
I
V
T
A
I
Q
A
A
N
-
M
T
R
G
T
-
T
G
V
C
V
L
A
A
Q
A
G
A
K
V
H
V
I
D
V
G
I
D
A
E
-
P
-
I
-
P
G
V
V
N
--
M
-
R
V
A
R
G
C
G
N
I
A
V
G
P
A
M
S
R
L
Q
A
E
A
L
L
L
E
V
S
R
Y
T
C
D
L
A
Q
R
G
V
T
L
F
G
V
G
E
L
G
M
A
N
T
T
P
A
A
A
M
V
S
V
F
T
G
S
D
A
K
E
V
V
G
I
G
A
N
L
P
P
S
R
I
D
N
K
V
D
V
V
R
R
A
I
A
I
N
Q
P
N
P
R
D
G
I
D
V
L
S
K
V
G
G
F
D
L
V
G
M
T
G
V
M
L
G
A
A
R
C
G
L
P
V
L
L
D
G
F
L
S
Y
S
A
A
L
A
A
C
Q
I
A
P
A
V
R
P
Y
L
I
P
S
H
F
S
A
E
K
G
A
R
I
A
L
A
H
L
S
M
E
P
Y
L
H
M
A
M
R
L
G
E
G
S
G
A
A
L
A
M
P
I
V
E
A
A
C
A
M
F
H
N
M
G
E
L
A
A
S
N
I
------------------
6
PsiBlast_PDB
89.04
35%
-88
- C10 -
4HDM
2
?
A:
[11-341]
------
A
K
I
M
R
P
D
T
V
I
K
D
Q
V
K
T
K
L
A
G
V
L
Q
S
A
G
S
L
G
R
L
E
D
M
V
E
Q
Y
A
G
I
T
G
-
E
L
N
P
-
A
L
P
K
P
C
M
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---
L
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---------
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---------------------------