@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2229c: (2016-05-08 )
MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE
Atome Classification :
(20 SA)
----------------------------.........10........20........30.-----.......40........50........60........70........80-------..--....-...90-..-......100.......110.......120...----....------130-------........140.......150.......160.......170.......180.....-..190..-----......200-------........210.---------......220....---...230.......240...--------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MKA
G
V
A
Q
Q
R
S
L
L
E
L
A
K
L
D
A
E
L
T
R
I
A
H
R
A
THL
P
-----
Q
R
A
A
Y
Q
Q
V
Q
A
EHNAAND
R
M
A
A
L
R
I
A
A
EDLD
G
Q
V
S
R
F
E
S
E
I
D
A
V
R
KRGD--------RD--
R
S
L
L
-TSGAT-
D
A
-
K
Q
L
A
D
L
Q
H
E
L
D
S
L
Q
R
R
Q
A
S
L
E
D
A
L
L
E
V
L
E
R
R
E
----
E
L
Q
A
------
Q
Q
--------
T
A
E
S
R
A
L
Q
A
L
R
A
D
L
A
A
A
Q
Q
A
L
D
E
A
L
A
E
I
D
Q
A
R
H
QHSSQR
D
M
L
T
ATL
D
P
E
L
A
G
L
Y
E
R
-
Q
RAG-GG-----PGAGRLQG--------HRC
G
A
C
R
I
EIGR---------G
E
L
A
Q
I
SAAAED
E
---
V
VRCPEC
G
A
I
L
L
R
LEGFEE--------------------------------------------------
21
HHSearch
92.57
16%
-61
- C3 -
3NA7
3
?
A:
[3-237]
-------------------------------
S
N
T
H
L
K
Q
L
I
E
I
S
H
L
D
K
E
I
D
S
L
E
P
L
I
R
E
K
R
-----
K
--
D
L
D
K
A
L
N
D
K
E
A
K
N
K
A
I
L
N
L
E
E
E
K
L
A
L
K
L
Q
V
S
K
N
E
Q
T
L
Q
D
T
N
A
K
I
A
--------
S
I
--
Q
K
K
M
-
S
E
I
K
--
S
E
-
R
E
L
R
S
L
N
I
E
E
D
I
A
K
E
R
S
N
Q
A
N
R
E
I
E
N
L
Q
N
E
I
K
----
R
K
S
E
------
K
Q
--------
E
D
L
K
K
E
M
L
E
L
E
K
L
A
L
E
L
E
S
L
V
E
N
E
V
K
N
I
K
E
T
Q
Q
I
I
F
K
K
K
E
D
L
V
E
K
T
E
P
K
I
Y
S
F
Y
E
R
-
I
R
R
W
A
K
N
-----
T
S
I
V
T
I
K
K
--------
Q
A
C
G
G
C
F
I
R
L
N
D
---------
K
I
Y
T
E
V
L
T
--
S
G
D
---
M
I
T
C
P
Y
C
G
R
I
L
Y
A
E
G
A
-----------------------------------------------------
22
HHSearch
91.36
18%
-65
- C3 -
4ILO
2
?
A:
[2-236]
-----------------------------
N
A
M
H
D
A
L
Q
S
I
L
A
I
Q
E
L
D
I
K
M
I
R
L
M
R
V
K
K
E
H
Q
-----
N
--
E
L
A
K
I
Q
A
L
K
T
D
I
R
R
K
V
E
E
K
E
Q
E
M
E
K
L
K
D
Q
I
K
G
G
E
K
R
I
Q
E
I
S
D
Q
I
N
--------
K
L
--
E
N
Q
Q
-
A
A
V
K
--
K
M
-
D
E
F
N
A
L
T
Q
E
M
T
A
A
N
K
E
R
R
T
L
E
H
Q
L
S
D
L
M
D
K
Q
A
----
G
S
E
D
------
L
L
--------
I
S
L
K
E
S
L
S
S
T
E
N
S
S
S
A
I
E
E
E
I
R
E
N
I
R
K
I
N
E
E
G
R
S
L
L
S
Q
R
T
Q
L
K
E
T
T
D
P
E
L
F
S
V
Y
E
R
-
L
L
N
N
K
K
D
-----
R
V
V
V
P
I
E
N
--------
R
V
C
S
G
C
H
I
A
L
T
P
---------
Q
H
E
N
L
V
R
K
--
Q
D
H
---
L
V
F
C
E
H
C
S
R
I
L
Y
W
Q
-------------------------------------------------------
44
Fugue
90.57
15%
-57
- C3 -
3NA7
3
?
A:
[1-237]
-----------------------------
L
G
S
N
T
H
L
K
Q
L
I
E
I
S
H
L
D
K
E
I
D
S
L
E
P
L
I
R
E
K
R
-----
K
D
L
D
--
K
A
L
N
D
K
E
A
K
N
K
A
I
L
N
L
E
E
E
K
L
A
L
K
L
Q
V
S
K
N
E
Q
T
L
Q
D
T
N
A
K
I
A
--------
S
I
--
Q
K
K
M
-
S
E
I
K
S
-
E
--
R
E
L
R
S
L
N
I
E
E
D
I
A
K
E
R
S
N
Q
A
N
R
E
I
E
N
L
Q
N
E
I
K
----
R
K
S
E
------
K
Q
--------
E
D
L
K
K
E
M
L
E
L
E
K
L
A
L
E
L
E
S
L
V
E
N
E
V
K
N
I
K
E
T
Q
Q
I
I
F
K
K
K
E
D
L
V
E
K
T
E
P
K
I
Y
S
F
Y
E
R
-
I
R
R
W
A
K
N
-----
T
S
I
V
T
I
K
K
--------
Q
A
C
G
G
C
F
I
R
L
N
D
---------
K
I
Y
T
E
V
L
T
S
--
G
D
---
M
I
T
C
P
Y
C
G
R
I
L
Y
A
E
G
A
-----------------------------------------------------
1
PsiBlast_PDB
77.32
24%
-58
- C3 -
4ILO
2
?
A:
[71-233]
-------------------------------------------------------------------------------------------
Q
E
I
S
D
Q
I
N
K
L
E
N
Q
Q
A
A
V
K
K
M
D
E
--------
F
N
----
A
L
-
T
Q
E
M
T
-
A
A
N
K
E
R
R
T
L
E
H
Q
L
S
D
L
M
D
K
Q
A
G
S
E
D
L
L
I
S
L
K
E
S
L
S
----
S
T
E
N
------
S
S
----------------------
S
A
I
E
E
E
I
R
E
N
I
R
K
I
N
E
E
G
R
S
L
L
S
Q
R
T
Q
L
K
E
T
T
D
P
E
L
F
S
V
Y
E
R
-
L
L
N
N
-
K
K
DRVV
V
P
I
E
N
R
V
------------
C
S
G
C
H
I
A
L
T
P
---------
Q
H
E
N
L
V
R
--
K
Q
D
H
---
L
V
F
C
E
H
C
S
R
I
L
----------------------------------------------------------
19
PsiBlast_PDB
75.46
24%
-39
- C3 -
2R05
1
PDC6I_HUMAN
A:
[367-526]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
FKERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.33
24%
-37
- C3 -
2XS8
1
PDC6I_HUMAN
A:
[374-533]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
F
K
ERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.11
24%
-37
- C3 -
2R02
1
PDC6I_HUMAN
A:
[367-526]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
FKERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.93
24%
-40
- C3 -
2R03
1
PDC6I_HUMAN
A:
[367-526]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
FKERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.27
24%
3
- C3 -
2OEX
-
PDC6I_HUMAN
A:
[361-527]
------------------------------------------------------------VS
V
Q
Q
S
L
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
F
KERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.13
24%
-32
- C3 -
2OEV
-
PDC6I_HUMAN
A:
[368-527]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
FKERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.91
24%
-33
- C3 -
2XS1
1
PDC6I_HUMAN
A:
[374-533]
-------------------------------------------------------------------
A
A
Y
N
Q
R
K
A
D
--
L
V
N
R
S
I
A
Q
M
R
E
A
T
T
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
TVP
Q
S
I
L
T
K
S
--
R
S
V
I
-
E
Q
G
G
I
----
Q
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
FKERW
Q
R
--------
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
E
----------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
69.38
18%
-9
- C3 -
4CGK
7
?
A:
[42-392]
SNLT
A
Q
Q
Q
E
A
Q
K
Q
V
D
Q
I
Q
E
Q
V
S
A
I
Q
A
E
Q
S
N
L
Q
A
E
N
D
R
L
Q
A
E
S
K
K
L
E
G
E
I
T
E
L
S
K
N
I
V
S
R
N
-----
Q
S
L
E
K
Q
A
R
S
A
Q
T
N
G
A
V
T
S
Y
I
N
T
I
V
N
S
K
S
I
T
E
A
I
S
R
V
A
A
M
S
E
I
V
S
A
N
N
K
--------
M
L
--
E
Q
Q
K
-
A
D
K
K
A
-
I
S
-
E
K
Q
V
A
N
N
D
A
I
N
T
V
I
A
N
Q
Q
K
L
A
D
D
A
Q
A
L
T
T
K
Q
A
----
E
L
K
A
------
A
E
L
S
L
A
A
E
K
A
T
A
E
G
E
K
A
S
L
L
E
Q
K
A
A
A
E
A
E
A
R
A
A
A
V
A
E
A
A
Y
K
E
K
R
A
S
Q
Q
Q
S
V
L
A
S
A
N
T
N
L
T
A
Q
V
Q
A
V
-
S
E
S
A
-
A
A
-----
P
V
R
A
K
V
R
P
T
Y
S
TNASS
Y
P
I
G
E
C
T
W
G
V
K
T
L
A
PWAGDYW
G
N
G
A
Q
W
A
T
S
A
A
A
A
G
F
R
T
G
S
T
P
Q
V
G
A
I
A
C
W
N
D
G
G
Y
G
H
V
A
V
V
TAVESTT
R
I
Q
V
S
E
S
NYAGNRTIGNHRGWFNPTTTSE
G
F
V
T
Y
I
Y
AD
4
PsiBlast_PDB
64.63
24%
-18
- C3 -
4RH7
-
DYHC2_HUMAN
A:
[2256-2373]
----------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
E
S
N
L
K
K
T
E
D
R
K
R
K
L
E
E
L
L
N
S
V
G
Q
K
V
S
----
E
L
K
E
------
K
F
--------
Q
S
R
T
S
E
A
A
K
L
E
A
E
V
S
K
A
Q
E
T
I
K
A
A
E
V
L
I
N
Q
L
D
R
E
H
-
K
R
W
N
A
Q
V
V
E
I
T
E
E
L
A
T
L
P
K
R
-
A
Q
------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.40
17%
-79
- C3 -
3NA7
1
?
A:
[111-232]
-------------------------------------------------------------------------------------------------------------------------------------------
R
E
I
E
N
L
Q
N
E
I
----
K
R
K
S
----------
E
K
Q
E
----
D
L
K
---------------------
K
E
M
L
E
L
E
K
L
A
L
E
L
E
S
L
V
E
N
E
V
K
N
I
K
E
T
Q
Q
I
I
F
K
K
K
E
D
L
V
E
K
T
E
P
K
I
Y
S
F
Y
E
R
I
R
R
W
A
-
K
N
-----
T
S
I
V
T
I
K
K
--------
Q
A
C
G
G
C
F
I
R
L
N
D
---------
K
I
Y
T
E
V
L
T
S
G
--
D
---
M
I
T
C
P
Y
C
G
R
I
L
----------------------------------------------------------
45
Fugue
58.52
17%
-4
- C3 -
4LL7
11
SHE3_YEAST
A:
[2-95]
--------------------------------------------------------------------------------------------------------
S
R
V
I
E
S
L
H
D
--------
Q
I
--
D
M
L
T
-
K
T
N
L
Q
-
L
T
-
T
Q
S
Q
N
L
L
S
K
L
E
L
A
Q
S
K
E
S
K
L
L
E
N
L
N
L
L
K
N
E
N
E
----
N
L
N
S
------
I
F
--------
E
R
K
N
K
K
L
K
E
L
E
K
D
Y
S
E
L
S
N
R
Y
N
E
Q
K
E
K
M
D
Q
L
S
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
56.13
14%
-15
- C3 -
3OKQ
-
BUD6_YEAST
A:
[553-677]
-------------------------------------------------------------------------
S
S
N
R
M
Y
M
E
K
S
Q
T
E
L
G
D
L
S
D
T
L
L
S
K
V
D
D
L
Q
D
V
I
E
I
M
R
K
D
V
A
--------
E
R
RS
Q
P
A
K
-
K
K
L
E
T
-
V
S
-
K
D
L
E
N
A
Q
A
D
V
L
K
L
Q
E
F
I
D
T
E
K
P
H
W
K
K
T
W
E
A
E
L
----
D
K
V
C
------
E
E
--------
Q
Q
F
L
T
L
Q
E
E
L
I
L
D
L
K
E
D
L
G
K
A
L
E
T
F
D
L
I
K
L
C
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
55.81
13%
-14
- C3 -
4ILO
-
?
A:
[30-163]
-----------------------------------------------------------------------
E
H
Q
N
E
L
A
K
I
Q
A
L
K
T
D
I
R
R
K
V
E
E
K
E
Q
E
M
E
K
L
K
D
Q
I
K
G
G
E
K
R
I
Q
--------
E
I
--
S
D
Q
I
-
N
K
L
E
--
N
Q
-
Q
A
A
V
K
K
M
D
E
F
N
A
L
T
Q
E
M
T
A
A
N
K
E
R
R
T
L
E
H
Q
L
S
----
D
L
M
D
------
K
Q
--------
A
G
S
E
D
L
L
I
S
L
K
E
S
L
S
S
T
E
N
S
S
S
A
I
E
E
E
I
R
E
N
I
R
K
I
N
E
E
G
R
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
55.43
16%
-3
- C3 -
1IC2
-
TPM1_CHICK
A:
[1-79]
------------------------------------------------------------------------------------------------------------------------------------
M
D
A
-
I
K
-
K
K
M
Q
M
L
K
L
D
K
E
N
A
L
D
R
A
E
Q
A
E
A
D
K
K
A
A
E
E
R
S
K
----
Q
L
E
D
------
E
L
--------
V
A
L
Q
K
K
L
K
G
T
E
D
E
L
D
K
Y
S
E
S
L
K
D
A
Q
E
K
L
E
L
A
D
K
K
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
55.17
13%
9
- C3 -
2V71
-
NDEL1_RAT
A:
[54-148]
-----------------------------------------------------------------------------------------
Q
L
V
Q
A
E
Q
R
N
R
D
L
Q
A
D
N
Q
R
L
K
Y
E
V
E
--------
A
L
--
K
E
K
L
-
E
H
Q
Y
A
Q
S
Y
-
K
Q
V
S
V
L
E
D
D
L
S
Q
T
R
A
I
K
E
Q
L
H
K
Y
V
R
E
L
E
Q
A
N
D
----
D
L
E
R
------
A
K
--------
R
A
T
I
M
S
L
E
D
F
E
Q
R
L
N
Q
A
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
53.78
20%
36
- C3 -
5CFF
-
?
A:
[503-589]
------------------------------------------------------------------------------------------
G
S
E
F
E
L
R
R
Q
A
S
N
Y
Q
L
T
L
T
N
T
R
A
T
--------
V
N
--
I
--
L
M
E
R
L
K
K
-
S
D
-
A
D
V
E
Q
Y
R
A
E
L
E
S
V
Q
L
A
K
G
A
L
E
Q
S
Y
L
V
L
Q
A
D
A
E
----
Q
L
R
Q
------
Q
L
--------
T
E
S
Q
D
A
L
N
A
L
R
S
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------