@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3102c: (2016-05-16 )
MITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKSTFMRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVAFALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVRDEQRGVYGMDR
Atome Classification :
(26 SA)
---.........10.--..--..--.--..20........30........40........50........60........70........80.......--..90........100..-.....110......-----...120.......130........140.......150.......160.......170......-.180..-.-.-.-..190.......200.......210.....-..-220.......---------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MI
T
L
D
H
V
T
K
Q
Y
K
--SS--AR--P--ALD
D
I
N
V
K
IDKG
E
F
V
F
L
IGPSGS
G
K
S
T
F
M
R
L
L
LAAETPTSG
D
V
R
V
S
K
F
H
V
N
K
LRGR
H
V
P
K
L
R
Q
-
V
I
G
C
V
F
Q
--
D
F
R
L
L
Q
Q
K
T
V
Y
D
N
V
A
F
A
-
L
E
V
I
GK--
R
T
D
A
I
N
-----
R
V
V
P
E
V
L
E
T
VGLSGK-ANRLPDELSGG
E
Q
Q
R
V
A
I
A
R
A
F
VNR
P
L
V
L
L
A
DEPTGNLDPE
T
S
R
D
I
M
-
D
L
L
E
R
I-N-R-T-G
T
T
V
L
M
ATH
D
H
H
I
V
D
S
M
R
Q
R
V
V
E
L
S
L
G
R
L
V
-
R
D
-
E
QRGVYGMDR---------------------------------------------------------------------------------------------------------------------
108
HHSearch
95.64
40%
-113
- C1 -
3TUI
1
METN_ECOLI
C:
[24-251]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
TR
T
I
--
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
T
V
S
E
V
-------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.92
40%
-119
- C1 -
3TUI
1
METN_ECOLI
C:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.49
40%
-124
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
94.07
40%
-121
- C1 -
3TUI
1
METN_ECOLI
H:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
93.24
40%
-120
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
93.07
40%
-119
- C1 -
3TUI
1
METN_ECOLI
D:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
92.39
40%
-117
- C1 -
3TUI
1
METN_ECOLI
G:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
92.02
40%
-124
- C1 -
1L2T
4
Y796_METJA
B:
[1-228]
---
M
I
K
L
K
N
V
T
K
T
Y
K
--
M
G
--
E
E
II
Y
--
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
--
I
F
K
--
Y
R
G
A
M
S
GEERR
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
-
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
-
R
E
-
E
K
-----------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
91.93
39%
-127
- C1 -
3TIF
7
Y796_METJA
B:
[1-228]
---
M
V
K
L
K
N
V
T
K
T
Y
K
--
M
G
--
E
E
II
Y
--
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
--
I
F
K
--
Y
R
G
A
M
S
GEERR
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
-
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
-
R
E
-
E
K
-----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.91
40%
-115
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.85
40%
-120
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-246]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.83
39%
-120
- C1 -
3TIF
7
Y796_METJA
A:
[1-228]
---
M
V
K
L
K
N
V
T
K
T
Y
K
--
M
G
--
E
E
I
I
Y
--
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
--
I
F
K
--
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
-
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
-
R
E
-
E
K
-----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.50
40%
-118
- C1 -
3DHW
-
METN_ECOLI
C:
[1-223]
---
M
I
K
L
S
N
I
T
K
V
F
H
--
Q
G
--
T
R
--
T
IQ
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
R
R
-
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-
E
Q
-
D
------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.49
40%
-120
- C1 -
1L2T
4
Y796_METJA
A:
[1-228]
---
M
I
K
L
K
N
V
T
K
T
Y
K
--
M
G
--
E
E
I
I
Y
--
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
--
I
F
K
--
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
-
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
-
R
E
-
E
K
-----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.15
40%
-121
- C1 -
1F3O
2
Y796_METJA
A:
[2-228]
----
I
K
L
K
N
V
T
K
T
Y
K
--
M
G
--
E
E
II
Y
--
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
--
I
F
K
--
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
-
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
-
R
E
-
E
K
-----------------------------------------------------------------------------------------------------------------------------
125
Fugue
87.39
39%
-114
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--H
M
I
K
L
S
N
I
T
K
V
F
H
QG
T
R
--
T
I
--
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
D
N
T
--
P
K
D
E
V
K
-----
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
-
T
V
S
E
V
F
S
H
P
K
TPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-----------
127
Fugue
83.03
38%
-105
- C1 -
1Z47
1
?
A:
[11-355]
GSM
T
I
E
F
V
G
V
E
K
I
Y
P
--
G
G
---
A
--
R
--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
-----
P
P
Q
K
R
-
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
R
V
--
P
K
D
E
M
D
-----
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
-
T
F
V
R
Q
V
-
H
-
D
-
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
-
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
11
PsiBlast_PDB
82.83
39%
-106
- C1 -
2IT1
-
?
A:
[4-214]
----
I
K
L
E
N
I
V
K
K
F
G
--
N
F
--
T
------
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
----
P
K
D
R
N
-
V
-
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
K
A
--
P
R
E
E
I
D
-----
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
-
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
-
A
E
L
K
R
L
-
Q
-
K
-
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
-
Q
---------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
82.78
36%
-125
- C1 -
2OUK
1
?
A:
[24-240]
---
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
L
--
E
------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
M
K
V
R
K
WP
R
E
K
A
E
A
-----
K
A
M
-
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
--------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
82.48
36%
-121
- C1 -
2OLJ
4
?
A:
[24-240]
---
M
I
D
V
H
Q
L
K
K
S
F
G
--
S
L
--
E
------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
M
K
V
R
K
WP
R
E
K
A
E
A
-----
K
A
M
-
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
--------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.87
36%
-108
- C1 -
4U00
3
?
A:
[20-219]
-----------------------------
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--
D
R
A
L
R
E
I
R
R
-
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
--
P
R
E
K
A
E
-----
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
-
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-
E
E
--------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
64.25
32%
-109
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[7-224]
------
I
G
H
L
S
K
S
F
Q
--
N
T
------
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
--
R
T
A
Q
E
R
-----
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
-
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
-
Q
---------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
63.66
34%
-119
- C1 -
1VCI
1
?
A:
[13-229]
----
V
K
L
E
N
L
T
K
R
F
G
--
N
F
--
T
------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
----
P
K
D
R
N
--
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
--
P
K
D
E
I
D
-----
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
-
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
-
A
E
I
K
K
L
Q
Q
-
K
-
L
-
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
-
Q
---------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
63.13
32%
-107
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[7-219]
------
I
G
H
L
S
K
S
F
Q
--
N
T
------
P
--
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
--
R
T
A
Q
E
R
-----
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
-
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
-
Q
---------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.94
31%
-114
- C1 -
4MKI
4
ECFA2_CALS4
A:
[26-226]
----------------------------
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
S
L
K
D
I
R
K
-
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
L
--
S
E
E
E
V
K
-----
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
-
K
-
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
60.32
31%
-113
- C1 -
4MKI
4
ECFA2_CALS4
B:
[26-226]
----------------------------
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
S
L
K
D
I
R
K
-
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
G
L
--
S
E
E
E
V
K
-----
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
-
K
-
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
------------------------------------------------------------------------------------------------------------------------------------