@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1071: (2016-01-26 )
MSRPILEVSGLTMRFGGLLAVNGVNLKVEEKQVVSMIGPNGAGKTTVFNCLTGFYQPTGGLIRLDGEEIQGLPGHKIARKGVVRTFQNVRLFKEMTAVENLLVAQHRHLNTNFLAGLFKTPAFRRSEREAMEYAAHWLEEVNLTEFANRSAGTLAYGQQRRLEIARCMMTRPRILMLDEPAAGLNPKETDDLKALIAKLRSEHNVTVLLIEHDMKLVMSISDHIVVINQGAPLADGTPEQIRDNPDVIKAYLGEA
Atome Classification :
(27 SA)
.........10....-..----..20........30........40........50........60.....------...-70-....------------...--..80........90........100-...----....110.......120.......130.......140-......--..150.......160.......170........180.......190.......200.......210.......220.......-230.......240--.....--....250...------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRP
I
L
EVSG
L
T
M
RF-G
G
----
L
L
A
VNG
V
N
L
K
V
E
E
K
Q
V
V
S
M
IGPNGAG
K
T
T
V
F
N
C
L
T
G
FYQPTG
G
L
I
R
LD
G
------
E
EI-Q--GLPG------------
H
K
I
--
A
R
K
G
V
V
R
T
F
Q
N
V
R
L
F
K
E
M
T
A
V
E
N
L
L
-
V
A
Q
----
H
RHL
N
T
N
F
L
A
G
L
FKTP
A
F
R
R
S
E
R
E
A
M
E
Y
A
A
H
W
L
E
EV--
N
L
T
E
F
A--NRSAGTLAY
G
Q
Q
R
R
L
E
I
A
R
C
M
MT-RP
R
I
L
M
L
DEPAAGLNPK
E
T
D
D
L
K
A
L
I
A
K
L
RSEH
N
V
T
V
L
L
IEHD
M
K
L
V
M
SISD
H
I
V
V
I
NQ-GAPLADG
T
P
E
Q
----IRD
N
P
--
D
V
I
K
A
Y
LGEA------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.22
32%
-110
- C1 -
1GAJ
7
LIVG_METJA
A:
[7-257]
----
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
N
P
G
E
S
P
L
N
S
L
F
Y
K
--
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
Q
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.98
32%
-119
- C1 -
1G6H
3
LIVG_METJA
A:
[7-257]
----
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
I
C
PG
E
S
P
L
N
S
L
F
Y
K
------
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------
50
Fugue
91.66
34%
-112
- C1 -
1G6H
3
LIVG_METJA
A:
[4-257]
-
T
M
E
I
L
R
T
E
N
I
V
K
Y
F
-
G
-EF--
K
A
L
D
-
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
KDITNK---------
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
C
P
G
E
S
P
L
N
S
L
F
Y
K
K
W
--
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
-
S
H
L
YD-
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N-
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
-N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
E
-------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.30
32%
-111
- C1 -
1G9X
3
LIVG_METJA
B:
[7-256]
----
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
N
P
G
E
S
P
L
N
S
L
F
Y
K
--
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
EIKN
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
--------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.19
32%
-109
- C1 -
1G9X
4
LIVG_METJA
A:
[7-256]
----
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
N
P
G
E
S
P
L
N
S
L
F
Y
K
--
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
--------------------------------------------------------------------------------------------------------------
46
HHSearch
89.14
34%
-115
- C1 -
1G6H
3
LIVG_METJA
A:
[4-243]
-
T
M
E
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
C
P
G
E
S
P
-
L
N
S
L
F
Y
K
K
W
I
-
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
----
E
I
K
N
V
--
L
S
D
P
K
V
V
E
I
Y
------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.05
31%
-119
- C1 -
1JI0
1
?
A:
[2-240]
V
S
D
I
V
L
E
V
Q
S
L
H
V
Y
Y
-
G
A
----
I
H
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
N
G
------
Q
D
I
-
T
--
N
K
P
A
------------
H
V
I
--
N
R
M
G
I
A
L
V
P
E
G
R
R
I
F
P
E
L
T
V
Y
E
N
L
M
-
M
G
---------------------
A
Y
N
R
K
D
K
E
G
I
K
R
D
L
E
W
I
F
S
L
F
P
R
L
K
E
R
L
--
K
Q
L
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
-
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
E
-
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
E
T
-
G
Q
I
V
L
E
G
K
A
S
E
----
L
L
D
N
E
--
M
V
R
K
A
Y
L
G
V
A
------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.08
32%
-105
- C1 -
1G9X
3
LIVG_METJA
C:
[7-256]
----
I
L
R
T
E
N
I
V
K
Y
F
-
G
E
----
F
K
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
------
K
D
I
-
T
--
N
K
E
P
------------
A
E
L
--
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
-
I
G
E
----
I
N
P
G
E
S
P
L
N
S
L
F
Y
K
--
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
--
K
L
S
H
L
Y
--
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
-
G
Q
I
I
A
E
G
R
G
E
E
EIKN
V
L
S
D
P
--
K
V
V
E
I
Y
I
G
--------------------------------------------------------------------------------------------------------------
48
HHSearch
87.20
31%
-110
- C1 -
1B0U
4
HISP_SALTY
A:
[5-244]
---
N
K
L
H
V
I
D
L
H
K
R
Y
-
G
G
----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
------
Q
N
I
-
N
--
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
--
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
-
E
A
P
----
I
Q
V
L
G
--------------
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
--
G
I
D
E
R
A
Q-
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
----
V
F
G
N
P
--
Q
S
P
R
L
Q
Q
F
L
K
------------------------------------------------------------------------------------------------------------
56
Fugue
86.27
26%
-121
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
GTRT
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
------
Q
E
L
-
T
--
T
L
S
E
------------
S
E
L
TK
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
P
L
----
E
L
D
---------------
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
----
V
F
S
H
P
KT
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------
23
PsiBlast_CBE
86.22
32%
-113
- C1 -
4WBS
1
?
B:
[40-278]
-----
L
V
V
R
N
L
K
K
R
Y
-
G
S
----
R
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
D
G
------
K
S
I
-
S
--
L
L
P
I
------------
H
K
R
--
A
S
L
G
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
S
V
E
E
N
I
R
-
A
V
L
----
E
L
Q
V
G
-----------
G
K
R
L
S
K
D
A
I
A
S
R
T
E
A
L
L
D
E
L
--
Q
I
S
H
L
R
--
E
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
-
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
-
K
F
L
K
Q
R
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
-
G
S
V
L
A
A
G
A
P
G
D
----
I
I
E
N
E
--
S
V
R
R
V
Y
L
G
E
H
------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.33
32%
-112
- C1 -
4WBS
1
?
A:
[40-278]
-----
L
V
V
R
N
L
K
K
R
Y
-
G
S
----
R
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
D
G
------
K
S
I
-
S
--
L
L
P
I
------------
H
K
R
--
A
S
L
G
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
S
V
E
E
N
I
R
-
A
V
L
----
E
L
Q
V
G
D
D
---------
G
K
R
L
S
K
D
A
I
A
S
R
T
E
A
L
L
D
E
L
--
Q
I
S
H
L
R
--
E
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
-
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
-
K
F
L
K
Q
R
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
-
G
S
V
L
A
A
G
A
P
G
D
----
I
I
E
N
E
--
S
V
R
R
V
Y
L
G
E
H
------------------------------------------------------------------------------------------------------------
55
Fugue
85.26
29%
-116
- C1 -
1Z47
1
?
A:
[11-355]
-
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
V
-
T
--
D
L
P
P
------------
Q
K
-----
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
-
F
G
L
----
R
E
K
---------------
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
E
S
Y
A
--
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
-
G
N
V
E
Q
F
G
T
P
E
E
----
V
Y
E
K
P
GT
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--
52
Fugue
84.44
27%
-107
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
--
I
I
V
K
N
V
S
K
V
F
-
K
K
GK--
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
------
R
L
V
-
A
SN
G
K
L
I
------------
V
P
P
--
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
P
L
----
T
N
M
---------------
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
H
V
L
--
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
-
G
K
L
V
Q
V
G
K
P
E
D
----
L
Y
D
N
P
VS
I
Q
V
A
S
L
I
G
E
I
NELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
13
PsiBlast_PDB
82.60
30%
-121
- C1 -
4YMW
-
?
J:
[4-223]
-------
V
N
D
V
Y
K
N
F
-
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
N
N
--
G
K
V
N
------------
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
----
V
K
V
K
K
M
N
--------------
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
----
I
F
Y
R
A
--
K
N
E
R
T
R
E
F
L
S
------------------------------------------------------------------------------------------------------------
45
HHSearch
82.49
28%
-115
- C1 -
2OLJ
4
?
A:
[22-251]
--
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
-
K
--
A
K
D
T
N-----------
L
N
K
--
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
A
P
----
M
K
V
R
K
--
W
------------
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
----
L
F
D
R
P
--
Q
H
E
R
T
K
A
F
L
S
------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.47
30%
-116
- C1 -
2YYZ
3
?
A:
[2-225]
---
P
S
I
R
V
V
N
L
K
K
Y
F
-
G
K
----
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
------
V
L
V
-
N
--
D
I
P
P
-------------
K
Y
--
R
E
V
G
M
V
--
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
--------------------
F
P
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
--
L
I
D
N
L
L
--
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
-
G
K
L
V
Q
Y
G
T
P
D
E
----
V
Y
D
S
P
--
K
N
M
F
V
A
S
F
I
G
------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.32
30%
-119
- C1 -
4YMT
-
?
J:
[4-223]
-------
V
N
D
V
Y
K
N
F
-
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
N
N
--
G
K
V
N
------------
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
----
V
K
V
K
K
M
N
--------------
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
----
I
F
Y
R
A
--
K
N
E
R
T
R
E
F
L
S
------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.24
30%
-120
- C1 -
4YMS
-
?
J:
[4-223]
-------
V
N
D
V
Y
K
N
F
-
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
N
N
--
G
K
V
N
------------
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
----
V
K
V
K
K
M
N
--------------
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
----
I
F
Y
R
A
--
K
N
E
R
T
R
E
F
L
S
------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.05
30%
-119
- C1 -
4YMU
2
?
J:
[4-223]
-------
V
N
D
V
Y
K
N
F
-
G
S
----
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
N
N
--
G
K
V
N
------------
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
----
V
K
V
K
K
M
N
--------------
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
----
I
F
Y
R
A
--
K
N
E
R
T
R
E
F
L
S
------------------------------------------------------------------------------------------------------------
41
HHSearch
80.26
31%
-116
- C1 -
1JI0
1
?
A:
[3-231]
-
S
D
I
V
L
E
V
Q
S
L
H
V
Y
Y
-
G
A
----
I
H
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
N
G
------
Q
D
I
-
T
--
N
K
P
A
------------
H
V
I
--
N
R
M
G
I
A
L
V
P
E
G
R
R
I
F
P
E
L
T
V
Y
E
N
L
M
-
M
G
A
----
Y
N
R
K
D
----------------
K
E
G
I
K
R
D
L
E
W
I
F
S
L
F
P
-
R
L
K
E
R
L
--
K
Q
L
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
-
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
-
E
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
E
T
-
G
Q
I
V
L
E
G
K
A
S
E
----
L
L
D
N
E
--
M
V
R
K
A
Y
L
G
V
A
------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.93
31%
-102
- C1 -
4QC2
2
?
A:
[4-236]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
R
V
Y
L
G
--------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
79.05
31%
-104
- C1 -
4QC2
2
?
B:
[4-236]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
R
V
Y
L
G
--------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.74
30%
-108
- C1 -
4P33
7
LPTB_ECOLI
A:
[3-235]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
R
V
Y
L
G
--------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.65
31%
-105
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-234]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
R
V
Y
L
---------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.71
31%
-107
- C1 -
4P32
2
LPTB_ECOLI
B:
[3-230]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
-------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.80
31%
-11
- C1 -
4P31
2
LPTB_ECOLI
A:
[3-234]
-----
L
T
A
K
N
L
A
K
A
Y
-
K
G
----
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
------
D
D
I
-
S
--
L
L
P
L
------------
H
A
R
--
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
----
I
R
D
----------
D
L
S
A
E
Q
R
E
D
R
-----
A
N
E
L
M
E
E
F
--
H
I
E
H
L
R
--
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
-
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
-
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
-
G
H
L
I
A
H
G
T
P
T
E
----
I
L
Q
D
E
--
H
V
K
R
V
Y
L
---------------------------------------------------------------------------------------------------------------