@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1964: (2016-02-03 )
MQFGAKPLFENVSVKFGNGNRYGLIGANGCGKSTFMKILGNDLEPSAGQVMLEPNVRLGKLRQDQFAYEDFSVIDTVIMGHEELWAVKAERDRIYSLPEMSEADGMAVAELEVQFAEFDGYTAESRAGELLLGLGIPLEQHFGPMSAVAPGWKLRVLLAQALFSDPDVLLLDEPTNHLDINTIRWLEGVLTARNSTMIIISHDRHFLNSVCTHMADLDYGELRLFPGNYDEYMTAAEQARERLLSDNAKKKAQIAELQSFVSRFSANASKAKQATSRARQIDKIQLEEVKPSSRVSPFIRFEQYKKLHRQAVTVENISKGYDGKPLFKGLSLQVEAGERVAIIGPNGIGKTTLLRCLVGDLPVDGGEVKWTDSADVGYFAQDHADDFADDMSLFDWMAQWTQGGEQLVRGTLGRMLFSNDEIKKSVKVISGGEQGRMLFGRLILKRPNVLVMDEPTNHLDMESIEALNLALDNYPGTLIFVSHDREFVSSLATRIIELGENGVTDFSGSYDDYLRSQGVIV
Atome Classification :
(20 SA)
-----------------------------------------------------------------------.....-....10.....-.-------------..20........30........40.....--.--..50...--------------.--...--.60....-..-.--.70.....--...80........90........100....-...----110.......120.......130...-----------....140.......150..-.....160....--...170.......180--.........190----.----......200.......210.....------..220.......230.......240.......250..-.....260.......270.......280.......290.......300.......310........320-.--......330.......340.......350.......360.---------------------......370...--------------.-----------..-------------...380.....------------------------------------------------------------------------..--390.------------------------------------------------------------------.....----.400--------------------------------------.-.-.-------.---------.....410.......420........430.......440.....---..450.......460.----......470---..----.----...----..480.......490....----...------500...----..-....510.......520-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------MQFGA-KPLFEN
V
S
V
K
F-G-------------NG
N
R
Y
G
L
I
GANGC
G
K
S
T
F
M
K
I
LGNDLEPS--A--
G
Q
V
M
LEP--------------N--VRL--GKLR
Q
D
Q
-FA-Y--
E
D
F
S
V
I
D
T
--
V
I
MG
H
E
E
L
W
A
V
KAERDRIYSLPEMSEAD
G
M
-
A
V
A
----
E
L
E
V
Q
F
AEFDGYTAESRAG
E
L
L
L
GLG-----------I
P
L
E
QHFG
P
M
S
AVAPG
W
K
L
-
R
V
L
L
A
Q
A
LFSDP--
D
V
L
L
LDEPTNHLD
I
----
N
T
I
R
W
L
E
G
V
LTA----R----N
S
T
M
I
I
I
SH
D
R
H
F
L
N
S
V
C
T
H
M
A
DL------DYG
E
L
R
LFPG
N
Y
D
E
Y
M
T
A
A
E
Q
A
R
E
R
L
L
SDN
A
K
K
K
A
Q
I
-
A
E
L
Q
S
F
V
S
R
FSA
N
A
S
K
A
K
Q
A
T
S
R
ARQI
D
K
I
Q
L
E
EVKPSSRV
S
P
F
I
R
F
E
Q
Y
K
K
L
H
R
Q
A
-
V
T
V
E
N
I
SKGYD-G--KPLFKG
L
S
L
Q
V
EAG
E
R
V
A
I
IGPNGI
G
K
T
T
L
L
R
C
L
V
GDLPV---------------------DGGE
V
K
W--TDS--------------A-----------DV-------------
G
Y
F
A
Q
DH
A
D
D
F
------------------------------------------------------------------------
A
D
--
D
M
S
L
------------------------------------------------------------------
F
D
W
M
A
----
Q
W
----------------------------------------
T
-Q-
G
-------
G
---------
E
Q
L
V
R
G
T
L
G
R
MLFS
N
D
E
-
I
K
K
S
V
K
V
ISGGEQ
G
R
M
L
F
G
R
L
I
LKRP---
N
V
L
V
MDEPTNHL
D
M
E
S
----
I
E
A
L
N
L
A
L----DN----Y----P
G
T
----
L
I
F
V
SH
D
R
E
F
V
S
S
L
A
T
R
I
I
----
E
LG------E--NGV----TD-FSG
S
Y
D
D
Y
L
R
SQGVIV------------------------------------
21
HHSearch
87.33
30%
-99
- C- -
2IW3
7
EF3A_YEAST
A:
[444-979]
------------------------------------------------------------------------
A
Y
G
A
-
K
I
L
L
N
K
T
Q
L
R
L
-
K
-------------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
----
D
--
G
F
P
T
Q
-
E
--------------
E
--
C
R
T
--
V
Y
V
E
H
D
I
-
D
G
T
H
--
S
D
T
S
V
L
D
F
--
V
F
E
S
G
--------------------------------------------
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
-----------
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
-
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
-----
Y
--------
E
E
L
S
N
-----------------
T
-----
D
L
E
-
F
K
F
P
E
P
-
G
----
Y
-
L
E
G
V
K
T
K
Q
K
A
I
-
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
--
H
E
N
--------------
C
-----------
R
I
-------------
A
Y
I
K
Q
H
A
F
A
H
I
------------------------------------------------------------------------
E
S
HL
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
G
----
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
G
Q
-
F
R
P
L------
T
---------
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
----
L
G
A
L
S
K
A
L
----
K
E
----
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
----
A
V
K
------
D
--
G
R
M
----
T
P
-
S
---------------------------------------------------
1
PsiBlast_PDB
84.65
29%
-72
- C1 -
3J5S
-
ETTA_ECOLI
D:
[27-536]
-------------------------------------------------------------------------------
I
L
K
N
I
S
L
S
F
-
F
-------------
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
--
E
--
G
E
A
R
P
Q
P
--------------
D
--
I
K
I
--
G
Y
L
P
Q
E
P
-
Q
L
-
N
--
P
E
H
T
V
R
E
S
--
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
-
K
L
A
AEQG
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
-----------
L
P
--
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
-
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
D
----
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
--
F
I
--
P
P
G
P
R
L
G
D
K
V
-
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
--
G
E
T
--------------
V
-----------
K
L
-------------
A
-----
S
V
D
Q
F
------------------------------------------------------------------------
R
D
--
S
M
D
N
------------------------------------------------------------------
S
K
T
V
W
----
E
E
----------------------------------------
V
-
S
-
G
-------
G
LDIMKIGNT
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
----
L
R
A
L
E
N
A
L
----
L
E
----
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
----
D
Y
Q
------
D
--
E
G
K
----
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
------------------------------------
2
PsiBlast_PDB
78.49
29%
-83
- C1 -
4FIN
12
ETTA_ECOLI
A:
[21-530]
-------------------------------------------------------------------------------
I
L
K
N
I
S
L
S
F
-
F
-------------
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
--
E
--
G
E
A
R
P
Q
P
--------------
D
--
I
K
I
--
G
Y
L
P
Q
E
P
-
Q
L
-
N
--
P
E
H
T
V
R
E
S
--
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
-
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
-----------
L
P
--
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
-
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
D
----
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
--
F
I
--
P
P
G
P
R
L
G
D
K
V
-
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
--
G
E
T
--------------
V
-----------
K
L
-------------
A
-----
S
V
D
Q
F
------------------------------------------------------------------------
R
D
--
S
M
D
N
------------------------------------------------------------------
S
K
T
V
W
----
E
E
----------------------------------------
V
-
S
-
G
-------
G
LDIMKIGNT
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
----
L
R
A
L
E
N
A
L
----
L
E
----
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
----
D
Y
Q
------
D
--
E
G
K
----
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
------------------------------------
20
PsiBlast_PDB
63.88
22%
-62
- C1 -
1YQT
4
?
A:
[47-472]
--------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
LC
G
--
D
N
D
S
W
D
G
--------------
V
--
I
R
A
F
R
G
N
E
L
Q
N
Y
-
F
E
-
K
--
L
K
N
G
E
I
R
P
--
V
V
K
P
Q
Y
V
D
L
I
P
K
A
V
K
G
K
V
I
E
L
--
L
K
K
A
D
E
T
-
G
K
L
----
E
E
V
V
K
A
L
E
L
E
N
V
---------------------------
L
E
R
E
I
Q
H
L
S
G
---
G
E
L
Q
-
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
-
L
S
E
----
E
----
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
I
I
H
V
------
V
Y
G
E
----
P
G
V
Y
G
I
F
-------------------
S
Q
P
-
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
---------------
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
--
G
--
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
T
V
A
--------------
Y
-----------
K
P
-------------
Q
Y
I
K
A
D
Y
E
G
T
V
------------------------------------------------------------------------
Y
E
--
L
L
S
K
------------------------------------------------------------------
I
D
--------
A
----------------------------------------
S
-
K
-
L
-------
N
---------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
I
R
H
L
M
E
K
----
N
----
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
----
V
F
E
------
G
--
E
P
G
----
K
Y
-
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
------------------------------------
24
HHSearch
60.19
19%
-77
- C1 -
1YQT
4
?
A:
[30-479]
------------------------------------------------------------------------
R
Y
G
V
N
A
F
V
L
Y
R
L
P
-
V
V
-
K
-------------
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
--
L
CG
D
N
D
S
W
D
G
--------------
V
--
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
-
L
--
K
N
G
E
I
R
P
V
--
V
K
P
Q
Y
V
D
L
I
P
K
------------------
A
-
V
K
G
----
K
V
I
E
L
---
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
-----------
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
-
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
N
A
A
R
A
I
R
R
----
L
S
E
E
-
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-
G
V
Y
-
G
I
F
S
Q
P
K
G
T
R
N
-
G
------------------
I
N
E
F
L
R
G
Y
L
K
D
--------
E
N
V
-
R
F
R
P
Y
E
-
I
K
F
T
K
T
---
G
E
R
V
-----
E
I
E
R
E
T
L
-
V
T
Y
P
R
L
V
K
D
Y
G
-
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
--
D
L
---------------------------
T
V
-------------
A
Y
K
P
Q
Y
I
K
A
--------------------------------------------------------------------------
D
Y
--
E
G
T
V
------------------------------------------------------------------
Y
E
L
L
S
----
K
I
----------------------------------------
D
-
A
-
S
-------
K
L
N
S------
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
I
----
R
H
----
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
----
V
F
E
------
G
--
E
P
G
----
K
Y
-
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
------------------------------------
23
HHSearch
59.80
19%
-59
- C1 -
3J16
2
RLI1_YEAST
B:
[86-558]
------------------------------------------------------------------------
R
Y
S
A
N
S
F
K
L
H
R
L
P
-
T
P
-
R
-------------
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
F
D
D
P
P
--------------
E
W
Q
E
I
I
--
K
Y
F
-
R
G
S
-
E
L
-
Q
N
Y
F
T
K
M
L
E
D
D
--
I
K
A
I
I
K
P
Q
-----
Y
V
---
D
N
I
P
R
A
I
K
G
----
P
V
Q
----
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
-----------
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
-
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
Q
R
L
N
A
A
Q
I
I
R
S
----
L
L
A
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
---
P
A
S
V
R
E
G
------------
I
----
N
I
F
L
D
G
H
I
P
A
----
E
N
L
R
F
R
T
---
E
A
L
Q
F
-
R
I
A
D
A
T
E
-
D
L
----
Q
N
--
D
S
A
S
R
A
-
F
S
Y
P
S
L
K
K
T
Q
--
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
----
P
K
--------------
L
-----------
N
V
-------------
S
M
K
P
Q
K
I
A
P
K
F
----------------------------------------------------------------------------
P
G
T
V
------------------------------------------------------------------
R
Q
L
F
F
----
K
K
----------------------------------------
I
-
R
-
G
QFL----
N
---------
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
-
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
----
R
I
I
C
S
K
V
I
----
R
R
----
F
I
L
H
N
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
----
V
F
E
------
G
I
P
S
K
N
----
A
--
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
------------------------------------
25
HHSearch
59.21
19%
-78
- C1 -
3OZX
5
?
A:
[14-463]
------------------------------------------------------------------------------
F
K
L
F
G
L
P
T
-
P
-
K
-------------
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
--
F
--
G
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
--
K
E
I
--
Y
N
Y
F
K
E
L
-
Y
--
S
--
N
E
L
K
I
V
H
K
--
I
Q
Y
V
E
Y
A
-
S
K
-------
F
L
-------------
K
G
----
T
V
N
E
I
L
T
---
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
-----------
M
T
-
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
-
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
----
R
E
R
M
N
M
A
K
A
I
R
E
----
L
L
K--
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
--
I
N
N
F
--------------
L
K
G
Y
L
P
A
---
E
N
M
K
I
R
-
P
D
E
I
K
F
M
L
K
-------------------------
L
K
T
K
-
M
K
W
T
K
I
I
K
K
L
G
----
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
V
T
P
--
E
K
Q
--------------------------
I
L
-------------
S
Y
K
P
Q
R
I
F
P
--------------------------------------------------------------------------
N
Y
--
D
G
T
V
------------------------------------------------------------------
Q
Q
Y
L
E
----
N
A
----------------------------------------
S
-
K
-
D
ALST---
S
---------
S
W
F
F
E
E
V
T
K
R
L
N
L
H
-
R
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
----
R
Y
I
V
A
K
A
I
----
K
R
----
V
T
R
E
R
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
----
V
F
K
------
G
--
E
P
E
----
K
A
-
G
L
A
T
S
P
V
T
L
K
T
G
M
N
E
F
------------------------------------
47
Fugue
58.30
18%
-52
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPFDA
I
Q
I
I
N
L
P
-
T
N
L
E
A
H
V
T
H
R
Y
-
S
AN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
F
D
D
P
P
--------------
E
----
W
--
Q
E
I
I
K
Y
F
-
R
G
-
S
--
E
L
Q
N
Y
F
T
K
--
M
L
E
D
D
I
K
A
------
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
-
P
V
Q
----
K
V
G
E
L
L
K
L
R
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
-----------
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
-
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
Q
R
L
N
A
A
Q
I
I
R
S
----
L
L
A
P
-
T
K
Y
V
I
C
V
E
H
D
----
L
S
V
L
D
Y
L
S
D
----------
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
--------
L
P
A
S
V
R
E
G
I
N
-
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
-
G
E
F
S
D
-----------------------
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
--
K
L
N
---------------------------
V
-------------
S
M
K
P
Q
K
I
A
P
K
F
------------------------------------------------------------------------
P
G
--
T
V
R
Q
------------------------------------------------------------------
L
F
F
K
K
----
I
R
----------------------------------------
G
-
Q
-
F
-------
L
---------
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
----
R
I
I
C
S
K
V
I
----
R
R
----
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
P
S
------
K
--
N
A
H
A
R
A
P
E
S
-
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
RRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
9
PsiBlast_PDB
57.70
21%
-78
- C1 -
3OZX
5
?
A:
[24-457]
-------------------------------------------------------------------------------------------------------
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
--
F
--
G
----
D
P
--------------
N
--
S
K
V
--
G
K
------------------
D
E
--
V
L
K
--------
R
F
R
G
K
E
I
Y
N
Y
F
K
E
L
Y
S
N
E
L
-
K
I
V
----
H
-
K
I
Q
Y
V
E
Y
A
S
K
F
L
K
G
T
V
N
E
I
L
T
K
I
D
ERGK
K
D
E
V
K
E
L
L
N
M
T
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
------
K
----
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
----
Y
L
T
D
L
----------
I
H
I
I
Y
G
E
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
N
F
L
K
G
Y
L
P
-
A
E
N
M
K
I
---------
R
P
D
E
I
K
F
M
L
K
---------
L
K
T
K
M
K
W
T
K
I
I
-----
K
K
L
G
D
F
Q
-
L
V
V
D
N
------------------
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
V
----
T
P
E
--------------
K
-----------
Q
I
L
S
Y
K
P
QRIFPNYD
G
T
V
Q
Q
Y
L
E
N
A
S
------------------------------------------------------------------------
K
D
--
A
L
S
T
------------------------------------------------------------------
S
S
W
F
F
----
E
---------------------------------------------------------------
E
V
T
K
R
L
N
L
H
R
L
L
E
S
N
-------
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
----
R
E
----
R
----
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
----
V
F
K
------
G
--
E
P
E
----
K
A
-
G
L
A
T
S
P
V
T
L
K
T
G
M
N
E
F
------------------------------------
22
HHSearch
55.68
20%
-71
- C1 -
3BK7
2
?
A:
[104-547]
------------------------------------------------------------------------------
N
A
F
V
L
Y
R
L
P
I
V
K
-------------
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
--
L
--
C
E
D
N
D
S
W
--------------
D
--
N
V
I
---
R
A
F
R
G
N
-
E
L
-
Q
--
N
Y
F
E
R
L
K
N
GE
I
R
P
V
V
---------------
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
----
K
V
R
E
L
L
---
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
-----------
L
E
-
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
-
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
K
V
A
R
V
I
R
R
----
L
A
N
E
-
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
----------------
I
N
E
F
L
Q
G
Y
L
K
D
E
N
------
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
E
-----------
R
V
D
V
E
R
E
T
L
-
V
E
Y
P
R
L
V
K
D
Y
G
-
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
--
D
L
---------------------------
T
V
-------------
A
Y
K
P
Q
Y
I
K
A
E
--------------------------------------------------------------------------
Y
--
E
G
T
V
------------------------------------------------------------------
Y
E
L
L
S
----
K
I
----------------------------------------
D
-
S
-
S
K
------
L
N
S-------
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
I
----
R
H
----
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
----
V
F
E
------
G
--
E
P
G
----
R
H
-
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
------------------------------------
4
PsiBlast_PDB
53.72
29%
-81
- C1 -
2IX3
6
EF3A_YEAST
A:
[443-776]
-----------------------------------------------------------------------
L
A
Y
G
A
-
K
I
L
L
N
K
T
Q
L
R
L
-
K
-------------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
----------
G
Q
V
-------------------------------
D
G
-
F
P
-
T
--
Q
--------------
E
E
C
R
T
V
Y
V
E
H
D
----------
I
D
G
T
-
H
S
D
----
T
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
-----------
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
-
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
----------------
K
K
C
P
---------------
A
A
K
A
Y
E
E
L
S
N
T
----
D
L
E
F
K
F
P
E
P
G
-------
Y
L
E
G
V
K
T
K
Q
K
A
I
-
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
--
H
E
N
--------------
C
-----------
R
I
-------------
A
Y
I
K
Q
-
H
A
--
F
------------------------------------------------------------------------
A
H
--
I
E
S
H
------------------------------------------------------------------
L
D
K
T
P
S
E
Y
I
Q
W
----------------------------------------
R
F
Q
-
T
-------
G
---------
E
D
--
R
E
T
M
D
R
A
N
R
Q
I
N
E
-
N
D
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
R
---
K
F
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
----
N
I
G
M
K
S
E
R
----
W
V
----
P
----
M
M
S
----
V
D
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
----
A
E
V
------
D
--
M
K
E
----
A
L
-
A
S
G
Q
F
R
P
L
T
R
K
E
I
E
E
H
------------------------------------
3
PsiBlast_PDB
52.19
29%
-80
- C1 -
2IWH
8
EF3A_YEAST
A:
[443-776]
-----------------------------------------------------------------------
L
A
Y
G
A
-
K
I
L
L
N
K
T
Q
L
R
L
-
K
-------------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
----------
G
Q
V
-------------------------------
D
G
-
F
P
-
T
--
Q
--------------
E
E
C
R
T
V
Y
V
E
H
D
----------
I
D
G
T
-
H
S
D
----
T
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
-----------
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
-
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
----------------
K
K
C
P
---------------
A
A
K
A
Y
E
E
L
S
N
T
----
D
L
E
F
K
F
P
E
P
G
-------
Y
L
E
G
V
K
T
K
Q
K
A
I
-
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
--
H
E
N
--------------
C
-----------
R
I
-------------
A
Y
I
K
Q
-
H
A
--
F
------------------------------------------------------------------------
A
H
--
I
E
S
H
------------------------------------------------------------------
L
D
K
T
P
S
E
Y
I
Q
W
----------------------------------------
R
F
Q
-
T
-------
G
---------
E
D
--
R
E
T
M
D
R
A
N
R
Q
I
N
E
-
N
D
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
R
---
K
F
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
----
N
I
G
M
K
S
E
R
----
W
V
----
P
----
M
M
S
----
V
D
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
----
A
E
V
------
D
--
M
K
E
----
A
L
-
A
S
G
Q
F
R
P
L
T
R
K
E
I
E
E
H
------------------------------------
6
PsiBlast_PDB
52.07
28%
-84
- C1 -
2IW3
6
EF3A_YEAST
A:
[443-769]
-----------------------------------------------------------------------
L
A
Y
G
A
-
K
I
L
L
N
K
T
Q
L
R
L
-
K
-------------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
----------
G
Q
V
-------------------------------
D
G
-
F
P
-
T
--
Q
--------------
E
E
C
R
T
V
Y
V
E
H
D
----------
I
D
G
T
-
H
S
D
----
T
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
-----------
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
-
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
----------------
K
K
C
P
---------------
A
A
K
A
Y
E
E
L
S
N
T
----
D
L
E
F
K
F
P
E
P
G
-------
Y
L
E
G
V
K
T
K
Q
K
A
I
-
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
--
H
E
N
--------------
C
-----------
R
I
-------------
A
Y
I
K
Q
-
H
A
--
F
------------------------------------------------------------------------
A
H
--
I
E
S
H
------------------------------------------------------------------
L
D
K
T
P
S
E
Y
I
Q
W
----------------------------------------
R
F
Q
-
T
-------
G
---------
E
D
R
E
T
M
D
R
A
N
R
Q
I
N
E
N
D
-
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
R
K
F
---
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
----
G
M
K
S
E
R
W
V
----
P
M
----
M
----
S
V
D
----
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
A
E
----
V
D
M
------
K
--
E
A
L
----
A
S
-
G
Q
F
R
P
L
T
R
K
E
I
E
E
H
C
S
------------------------------------
37
HHSearch
48.59
30%
-102
- C1 -
3TUI
1
METN_ECOLI
C:
[41-251]
-----------------------------------------------------------------------------
I
Q
A
L
N
N
V
S
L
H
V
-
P
-------------
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
--
E
--
G
S
V
L
V
D
G
QELTTLSESELTKA
R
--
R
Q
I
--
G
M
I
F
Q
H
F
-
N
L
-
L
--
S
S
R
T
V
F
G
N
--
V
A
L
P
L
E
L
D
N
T
-------------------------------------
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-----------
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
-
R
V
A
I
A
R
A
L
A
S
N
P
--
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
----
A
T
T
R
S
I
L
E
L
L
K
D
----
I
NRRL
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
-
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
-
K
F
G
I
M
L
T
E
M
H
G
-
T
--
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
47.71
29%
-100
- C1 -
1Z47
1
?
A:
[11-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
-
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
---------------------
T
K
G
D
V
W
I
--
G
G
K
RVTDLPPQK-----
R
-----------
N
V
-------------
G
L
V
F
Q
N
Y
A
--
L
------------------------------------------------------------------------
F
Q
--
H
M
T
V
------------------------------------------------------------------
Y
D
N
V
S
----
F
G
----------------------------------------
L
-
R
-
E
K
RVP
K
D
-
E
M
--------
D
A
R
V
R
E
L
L
R
F
M
R
L
E
-
S
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
----
R
R
E
L
R
T
F
V
----
R
Q
----
V
H
D
E
M
G
V
T
----
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
----
V
L
H
------
E
--
G
N
V
----
E
Q
--
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
------------------------------------
43
HHSearch
47.41
26%
-100
- C1 -
1OXX
21
?
K:
[3-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
I
I
V
K
N
V
S
K
V
F
K
-
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
---------------------
S
T
G
E
L
Y
F
--
D
D
R
LVASNGKLIVPPED
R
-----------
K
I
-------------
G
M
V
F
Q
T
W
A
--
L
------------------------------------------------------------------------
Y
P
--
N
L
T
A
------------------------------------------------------------------
F
E
N
I
A
----
F
P
----------------------------------------
L
-
T
-
N
MKMSKEE
I
---------
R
K
R
V
E
E
V
A
K
I
L
D
I
H
-
H
V
-
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
---
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
----
R
D
S
A
R
A
L
V
----
K
E
----
V
QSRL
G
V
T
----
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
----
V
L
V
------
K
--
G
K
L
----
V
Q
-
V
-
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
------------------------------------
27
HHSearch
47.23
21%
-64
- C1 -
2R6F
3
?
A:
[487-942]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
G
-----------
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
-
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
----
R
D
N
D
R
L
I
A
T
L
K
S
----
M
R
D
L-
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
-
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
-
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
------------------
G
Q
Y
L
S
--------------------
G
K
K
F
I
P
I
P
A
E
-----------
R
R
R
P
D
G
R
W
-
L
E
V
V
G
A
R
--------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
I
D
I
--
D
Q
S
--------------
P
IGRTPRSN
P
A
T
Y
T
-------------
G
V
-
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
L
--
D
M
T
V
------------------------------------------------------------------
E
D
A
L
D
----
F
F
----------------------------------------
A
-
S
-
I
-------
P
K
--------
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
----
I
A
R
L
L
D
V
L
----
H
R
----
L
V
D
N
-
G
D
T
----
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
----
D
L
G
PEGGDR
G
--
G
Q
I
----
V
A
--
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
------------------------------------
34
HHSearch
46.88
26%
-97
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[13-226]
------------------------------------------------------------------------
S
F
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
-
D
-------------
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
--
S
--
G
E
I
S
L
S
G
KTIFSKN
T
N
L
P
VR-
E
--
R
R
L
--
G
Y
L
V
Q
E
G
-
V
L
-
F
--
P
H
L
T
V
Y
R
N
--
I
A
Y
G
L
G
N
G
K
G
-------------------------------------
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-----------
I
S
-
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
-
R
A
A
L
A
R
A
L
A
P
D
P
--
E
L
I
L
L
D
E
P
F
S
A
L
D
E
----
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
----
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
------
K
Q
G
R
I
L
Q
T
-
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
F
P
A
A
-
L
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
-
A
R
H
T
E
I
S
L
R
A
G
-
Q
--
T
V
L
T
L
N
L
L
S
D
G
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.53
21%
-107
- C1 -
3RLF
3
MALK_ECOLI
A:
[12-216]
------------------------------------------------------------------------
A
W
G
E
-
V
V
V
S
K
D
I
N
L
D
I
-
H
-------------
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
--
S
--
G
D
L
F
I
G
E
KRMNDTPPA-----
E
--
R
G
V
--
G
M
V
F
Q
S
Y
-
A
L
-
Y
--
P
H
L
S
V
A
E
N
--
M
S
F
G
L
K
L
A
G
A
-------------------------------------
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-----------
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
-
R
V
A
I
G
R
T
L
V
A
E
P
--
S
V
F
L
L
D
E
P
L
S
N
L
D
A
----
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
----
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
-
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
D
V
I
L
E
-
G
E
V
Q
V
V
E
Q
L
G
N
-
E
--
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
---------------------
L
F
R
E
D
G
T
--
A
C
R
--------------
R
-----------
L
H
-------------
K
E
P
G
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
46.32
27%
-93
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[3-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-
L
H
I
G
H
L
S
K
S
F
Q
-
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
---------------------
D
S
G
E
I
S
L
--
S
G
K
TIFSKN
T
N
L
P
VRE-
R
-----------
R
L
-------------
G
Y
L
V
Q
E
G
V
--
L
------------------------------------------------------------------------
F
P
--
H
L
T
V
------------------------------------------------------------------
Y
R
N
I
A
----
Y
G
----------------------------------------
L
-
G
-
N
GKGRT
A
Q
E
---------
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
L
-
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
---
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
----
R
R
Q
I
R
E
D
M
----
I
A
A
L
R
A
N
----
G
K
S
----
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
----
V
M
K
------
Q
--
G
R
I
----
L
Q
--
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
------------------------------------