@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2397: (2016-02-07 )
MTNPKRGAIRELLALLRPFRAIVAVSIALGMAGGLAITLLLASINNALHSENGLGQGVLLSFGGLCLLALVSSIVSDIGTSYVGQHIIAKLRKELGEKVLSAPIEQIERYRTHRLIPVLTHDIDTISDFSFSFTPLAIALTITFGCLGYLAYLSVPMFLLTVVAIVIGTAAQYLARSRGFKGFYAARDLEDELQKHYTAIASGAKELRIHRPRRYRMHTGRISETANNIRDLHISSINIFILAKTFGSMLFFVVIGLALTLQAYWPSSNPAAITGFVMVLLYMKGPLEQVVTILPIVSRAQVAFQRVAELSERFSSPEPHLLLSEQEAPDKTVDSLELRDVRYSPPAVEGSEPFHLGPINLRIAQGDIVFIVGENGCGKTTLIKLLLGLYRPQSGEILLNGEPVSAETRDDYRQLFSTIFADYYLFDDLVQGKQASLQNATQYLQRLEIAHKVSVMDGNFSTTDLSTGQRKRLALINAWLEERPVLVFDEWAADQDPAFRRVFYTELLPDLKRQGKTIIVISHDDRYFEMADQLIRLSAGKVVKETETA
Atome Classification :
(21 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20-.-.......30........40.......-----.-------50...-----.--.---.---.---.---60..----......70........80---.........90........100.....--..110.......120....-...130..------...------...140..-.....150.....-..160.......170...-....180.......190.......---200.......210.......220.......230.......240..-.....250.....--..260..---.-----....270-.........----280.......290.......300.......310.......320...-....------330....----...340.......350...-------------....360.......370.......380.......390.---......400.......410-.........420....-----..-.430----------.--------..------------....440.......450-------.......460----.------.------.------......470.......480.......490......----.500.......510.--......520......-.530.......540.......------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTNP
K
R
G
A
I
R
E
L
L
A
L
L
R
P
F
R
A
-
I
-
V
A
V
S
I
A
L
GMA
G
G
L
A
I
T
L
L
L
A
S
I
N
N
A
L-----H-------SENGL-----G--Q---
G
---
V
---
L
---
L
S
FG----
G
L
C
L
L
A
L
V
S
S
I
V
S
D
I
G
T
----
S
Y
V
G
Q
H
I
I
A
K
L
R
K
E
L
G
E
K
V
L
S
A
P
I
E
Q
I
--
E
R
Y
R
THR
L
I
P
VLTHDIDTI-SDFSF-SF------
T
P
L
------
A
I
A
L
T
I
T
F
-
G
C
L
G
Y
L
A
Y
L
S
V
P
M
-
F
L
L
T
V
V
A
I
V
I
G
T
A
A
Q
Y
L
A
-
R
SRGFK
G
F
Y
A
AR
D
L
E
D
E
L
Q
K
H
Y
T
A
---
I
AS
G
A
K
E
L
R
IHRP
R
R
Y
RMHTGR
I
S
E
T
ANN
I
R
D
L
H
I
S
S
I
N
I
F
I
L
A
K
-
T
F
G
S
M
L
F
F
V
V
I
G
L
--
A
L
T
L
Q
A
Y---W-----PSSN
P
---
A
A
I
T
G
F
V
M
V
----
L
L
YMKG
P
L
E
Q
V
V
T
I
L
P
I
V
S
R
A
Q
V
A
F
Q
R
V
A
E
L
S
E
RFSSPEP
H
L
L
LSE-QEAP------DKTV
D
S
L
----
E
L
RDVRYSPPAVEGSEP
F
H
-------------LG
P
I
N
L
R
IAQG
D
I
V
F
I
VGENGC
G
K
T
T
L
I
K
L
L
L
G
LYRPQ---SG
E
I
L
LNGEPVSAE
T
R
D
---
D
Y
R
Q
L
F
S
T
I
F
A
D
Y
Y
L
F
-----
D
D
-
L
V
Q
G
----------
K
--------
Q
A
------------
S
L
Q
N
A
T
Q
Y
L
Q
R
L
E
I
A
H
K
-------
V
S
V
MDGNF------S------T------T------DLSTG
Q
R
K
R
L
A
L
I
N
A
W
L
EER
P
V
L
V
F
DEWAADQD
P
A
----
F
R
R
V
F
Y
T
E
L
L
P
D
L
K
R--QG
K
T
I
I
V
I
SHD
D
R
Y
F
-
E
M
A
D
Q
L
I
R
LSAG
K
V
V
KETETA------------------
3
PsiBlast_PDB
84.32
23%
-108
- C1 -
3B60
2
MSBA_SALTY
A:
[14-558]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
W
P
T
I
A
P
F
K
A
G
L
-
I
V
A
G
I
A
L
-
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
--------------
D
D
G
F
-----
G
--
K
TDR
S
---
V
---
L
---
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
----
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
-
A
L
------
I
T
V
------
V
R
E
G
A
S
I
I
-
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
---
S
K
R
F
R
S
I
--
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
----
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
L
--
A
L
A
F
V
L
Y
A
A
S
F
-----
P
S
V
M
D
---
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
------
F
A
-----
I
L
D
S
E
-
Q
E
K
D
E
G
K
RVI
D
R
A
T
G
D
L
----
E
F
R
N
V
T
F
T
Y
P
---
G
R
E
V
P
A
-------------
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
---
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-----
N
D
-
T
V
A
N
----------
N
--------
I
A
------------
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
YA
M
D
F
I
N
K
M
D
N
G
L
------
D
------
T
I
I
G
ENG
V
------
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
----
S
E
R
A
I
Q
A
A
L
--
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
-----------------------
23
HHSearch
83.34
21%
-104
- C1 -
3B60
2
MSBA_SALTY
A:
[10-562]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
-----
D
-------
D
G
F
G
K
-----
T
D-
R
S--
V
---
L
---
L
W
M
P
L
V
V
I
----
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
----
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
-
A
S
S
S
S
G
A
L
------
I
T
V
------
V
R
E
G
A
S
I
I
-
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
-
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
-
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
---
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
--
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
-
P
I
I
Q
L
I
A
S
L
A
L
A
F
--
V
L
Y
A
A
S
F
PSV
M
-----
D
S
L
T
A
---
G
T
I
T
V
V
F
S
S
----
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
------
R
V
I
------
D
R
A
T
G
D
L
----
E
F
R
N
V
T
F
T
Y
P
G
R
E
---
V
P
A
-------------
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
---
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-----
N
D
-
T
V
A
N
----------
N
--------
I
A
YARTEEY-----
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
-------
I
N
K
M
D
N
G
L
------
D
T
I
I
G
EN
G
------
V
------
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
----
S
E
R
A
I
Q
A
A
L
D
E
L
Q
----
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-------------------
9
PsiBlast_PDB
79.83
23%
-106
- C1 -
3QF4
2
?
A:
[51-555]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
I
-----
A
--
R
---
G
D
F
S
L
---
V
---
L
K
T
G
----
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
--
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
-
Q
N
L
V
M
-
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
-
K
L
S
S
V
L
I
F
L
I
P
P
I
-
V
L
L
F
V
----------
W
L
T
-
K
-
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
---
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
--
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
-
P
L
--
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
---
L
-----
V
R
N
N
Q
ME
I
G
S
I
M
A
Y
T
N
Y
----
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
------------
V
L
N
E
-
K
P
A
I
------
E
E
A
D
N
A
L
----
A
L
-------
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
YFENTDPV
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
---
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
-
L
K
W
G
----------
R
--------
E
D
------------
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
-----
I
S
L
P
E
G
Y
D
------
S
------
R
------
V
ERGGR-
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
----
T
E
K
----
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
-
L
L
A
D
K
I
L
V
L
H
E
G
K
V
-------------------------
26
HHSearch
79.82
17%
-100
* C1 *
3WMG
6
?
A:
[13-576]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
R
R
I
F
A
L
A
W
S
S
S
A
-
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
-----
Q
-------
V
F
T
K
S
K
S
Q
I
E
G
--
E
---
T
W
K
-
Y
---
S
---
V
G
F
V
----
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
----
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
--
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
-
Q
Y
S
F
S
-
K
L
------
G
A
V
------
L
F
N
L
A
Q
C
V
-
V
G
I
I
V
A
F
I
F
A
P
A
L
-
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
-
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
---
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
--
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
-
G
L
S
M
L
V
I
F
C
V
Y
A
L
--
A
L
W
W
G
G
Q
L
I
A
R
-----
G
S
L
N
L
---
G
N
L
L
T
A
F
F
S
----
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
Q
P
------
L
V
L
K
Q
G
I
----
V
F
E
N
V
H
F
R
Y
P
T
R
M
--
N
V
E
V
-------------
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
---
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-----
S
G
-
T
I
R
D
----------
N
--------
I
L
Y
GKRDA------
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
-------
V
M
A
L
P
D
G
L
------
D
T
E
V
G
ER
G
------
L
------
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
----
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
--
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
-
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-------------------
10
PsiBlast_PDB
79.51
23%
-105
- C1 -
4Q4A
2
?
A:
[51-555]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
I
-----
A
--
R
---
G
D
F
S
L
---
V
---
L
K
T
G
----
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
--
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
-
Q
N
L
V
M
-
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
-
K
L
S
S
V
L
I
F
L
I
P
P
I
-
V
L
L
F
V
----------
W
L
T
-
K
-
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
---
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
--
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
-
P
L
--
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
---
L
-----
V
R
N
N
Q
ME
I
G
S
I
M
A
Y
T
N
Y
----
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
------------
V
L
N
E
-
K
P
A
I
------
E
E
A
D
N
A
L
----
A
L
-------
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
YFENTDPV
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
---
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
-
L
K
W
G
----------
R
--------
E
D
------------
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
-----
I
S
L
P
E
G
Y
D
------
S
------
R
------
V
E
RGGR-
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
----
T
E
K
----
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
-
L
L
A
D
K
I
L
V
L
H
E
G
K
V
-------------------------
44
Fugue
78.89
20%
-98
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
DDGFG
K
-------
T
D
R
S
V
-----
L
--
L
---
W
---
M
---
P
---
L
V
V
I
----
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
----
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
-
A
S
S
S
S
-
G
A
------
L
I
T
------
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
-
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
-
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
---
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
--
A
A
S
F
P
S
V
---
M
-----
D
S
L
T
A
---
G
T
I
T
V
V
F
S
S
----
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
-----
G
-
K
R
V
I
------
D
R
A
T
G
D
L
----
E
F
R
N
V
T
F
T
Y
P
---
G
R
E
V
P
A
-------------
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
---
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-----
N
D
-
T
V
A
N
----------
N
--------
I
A
YARTEEY-----
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
-------
I
N
K
M
D
N
G
L
------
D
------
T
I
I
G
ENG
V
------
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
----
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
HG
V
Y
A
Q
L
H
K
M
QFG
11
PsiBlast_PDB
77.68
23%
-104
- C1 -
4Q4H
-
?
A:
[51-555]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
I
-----
A
--
R
---
G
D
F
S
L
---
V
---
L
K
T
G
----
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
--
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
-
Q
N
L
V
M
-
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
-
K
L
S
S
V
L
I
F
L
I
P
P
I
-
V
L
L
F
V
----------
W
L
T
-
K
-
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
---
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
--
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
-
P
L
--
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
---
L
-----
V
R
N
N
Q
ME
I
G
S
I
M
A
Y
T
N
Y
----
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
------------
V
L
N
E
-
K
P
A
I
------
E
E
A
D
N
A
L
----
A
L
-------
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
YFENTDPV
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
---
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
GT
I
K
E
N
-
L
K
W
G
----------
R
--------
E
D
------------
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
-----
I
S
L
P
E
G
Y
D
------
S
------
R
------
V
ERGGR-
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
----
T
E
K
----
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
-
L
L
A
D
K
I
L
V
L
H
E
G
K
V
-------------------------
48
Fugue
77.62
20%
-102
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
PSRPDVPILRG
M
N
L
R
V
N
AGQT
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
L
RYYDVL
K
G
K
I
T
I
DGVDVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
NCT
I
E
E
N
I
S
L
G
KEGIT
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
RNPK
I
L
L
L
D
EATSALDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
KG
R
T
T
I
I
I
A
HRLSTIRNAD
L
I
I
S
C
K
NGQVV
E
V
G
D
H
R
A
L
M
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
N
N
A
Q
K
T
N
L
F
E
I
L
Y
H
A
R
P
H
A
L
-
S
-
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
-----
N
V
F
AGNPA
D
F
L
S
Q
-----
G
--
H
---
F
---
W
---
A
---
L
M
F
L
----
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
----
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
DS
P
Q
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
-
R
F
------
S
T
V
------
I
T
T
L
V
S
M
V
-
A
G
I
G
L
A
F
F
Y
G
W
Q
M
-
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
---
I
E
---
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
-
G
C
A
S
S
V
L
Y
L
L
N
T
C
--
A
Y
R
M
G
L
A
---
L
I
I
TDP
P
T
M
Q
P
---
M
R
V
L
R
V
M
Y
A
----
I
T
I
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
S
K
I
D
S
---
L
S
L
-
A
G
E
K
------
K
K
L
Y
G
K
V
----
I
F
K
N
V
R
F
A
Y
P
--
E
R
P
E
I
E
I
-------------
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
P
E
---
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
-----
D
C
-
S
I
A
E
----------
N
I
I
YGLDPS
S
V
------------
T
M
A
Q
V
E
E
A
A
R
L
A
N
I
H
N
F
-------
I
A
E
L
P
E
G
F
------
E
------
T
------
R
VGDRGT
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
----
S
E
K
V
V
Q
E
A
L
--
D
R
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
N
T
V
-
M
N
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
K------------
7
PsiBlast_PDB
77.35
23%
-100
- C1 -
4Q4J
-
?
A:
[63-555]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
K
--
T
---
G
---
I
---
L
---
M
L
I
------
V
A
L
I
G
A
V
G
G
I
G
S
T
V
F
A
----
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
--
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
-
Q
N
L
V
M
-
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
-
K
L
S
S
V
L
I
F
L
I
P
P
I
-
V
L
L
F
V
----------
W
L
T
-
K
-
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
---
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
--
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
-
P
L
--
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
---
L
-----
V
R
N
N
Q
ME
I
G
S
I
M
A
Y
T
N
Y
----
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
------------
V
L
N
E
-
K
P
A
I
------
E
E
A
D
N
A
L
----
A
L
-------
P
N
V
E
G
S
V
S
F
E
N
V
E
F
R
YFENTDPV
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
---
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
SGT
I
K
E
N
-
L
K
W
G
----------
R
--------
E
D
------------
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
-----
I
S
L
P
E
G
Y
D
------
S
------
R
------
V
E
R
GGR-
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
----
T
E
K
----
R
I
L
D
G
L
K
R
Y
T
K
G
S
T
T
F
I
I
T
Q
K
I
P
T
A
-
L
L
A
D
K
I
L
V
L
H
E
G
K
V
-------------------------
25
HHSearch
73.02
17%
-96
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[4-565]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
-
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
-----
D
-------
V
I
Y
T
N
PTV--
D
Y
S
D
---
N
---
L
T
R
L
C
---
L
G
L
S
----
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
----
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
--
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
-
G
R
S
V
T
E
N
L
------
S
D
G
------
L
R
A
G
A
Q
A
S
-
V
G
I
S
M
M
F
F
V
S
P
N
L
-
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
-
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
---
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
--
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
-
G
A
T
G
L
S
G
N
L
I
V
L
S
--
V
L
Y
K
G
G
L
L
M
G
S
-----
A
H
M
T
V
---
G
E
L
S
S
F
L
M
Y
----
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
--
V
-
I
L
N
E
------
K
S
F
Q
G
A
L
----
E
F
K
N
V
H
F
A
Y
P
A
R
P
--
E
V
P
I
-------------
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
---
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-----
S
C
-
S
I
A
E
----------
N
--------
I
A
YGADDPSSV---
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
-------
I
R
N
F
P
Q
G
F
------
N
T
V
V
G
EK
G
------
V
------
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
----
N
E
Y
L
V
Q
E
A
L
D
R
L
M
----
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
-
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-------------------
37
HHSearch
64.70
29%
-107
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-218]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
----
Q
L
Q
N
V
T
K
A
W
G
E
V
-----
V
V
-------------
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
---
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
-----
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
-----
P
H
L
S
V
A
E
----------
N
--------
M
S
F
G
L
K
L
A
GAK
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
-------
L
D
R
K
-----------------
P
------
K
------
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
----
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
--
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
-------------------
43
HHSearch
63.31
26%
-85
- C1 -
2FF7
1
A:
[5-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
I
----
T
F
R
N
I
R
F
R
Y
K
P
D
S
---
P
V
I
-------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-----
N
R
-
S
I
I
D
----------
N
--------
I
S
LANPGM------
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
-------
I
S
E
L
R
E
G
Y
NTIVGE
Q
------
G
------
A
------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
----
S
E
H
V
I
M
R
N
M
H
K
I
-
C
---
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-------------------
31
HHSearch
62.73
25%
-94
- C1 -
3TUI
1
METN_ECOLI
C:
[23-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
----
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
-------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
ELT
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
-----
S
S
R
T
V
F
G
----------
N
--------
V
A
LPLELDNTPKDE
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-------
H
D
S
-----------
Y
------
P
------
S
------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
--
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
-------------------
39
HHSearch
62.56
26%
-98
- C1 -
3VX4
3
?
A:
[29-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
I
----
S
F
E
N
L
S
Y
K
Y
G
F
G
----
R
D
T
-------------
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
---
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-----
S
G
-
S
I
M
D
----------
N
--------
L
V
LGAKEGT-----
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
-------
I
E
Q
M
P
Q
G
Y
------
Q
T
E
L
S
D-
G
------
A
------
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
----
T
E
K
K
I
I
S
N
L
L
Q
-
M
T
----
E
K
T
I
I
F
V
A
H
R
L
S
I
S
-
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
-------------------
1
PsiBlast_PDB
62.54
23%
1
- C- -
3B5Y
2
MSBA_SALTY
A:
[14-558]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
W
P
T
I
A
P
F
K
A
G
L
-
I
V
A
G
I
A
L
-
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
--------------
D
D
G
F
-----
G
--
K
TDR
S
---
V
---
L
---
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
----
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
-
A
L
------
I
T
V
------
V
R
E
G
A
S
I
I
-
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
---
S
K
R
F
R
S
I
--
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
----
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
L
--
A
L
A
F
V
L
Y
A
A
S
F
-----
P
S
V
M
D
---
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
------
F
A
-----
I
L
D
S
E
-
Q
E
K
D
EGKRVI
D
R
A
T
G
D
L
----
E
F
R
N
V
T
F
T
Y
P
---
G
R
E
V
P
A
-------------
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
---
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-----
N
D
-
T
V
A
N
----------
N
--------
I
A
------------
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
YA
M
D
F
I
N
K
M
D
N
G
L
------
D
------
T
I
I
G
ENG
V
------
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
----
S
E
R
A
I
Q
A
A
L
--
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
-----------------------
2
PsiBlast_PDB
62.53
23%
1
- C- -
3B5Z
2
MSBA_SALTY
A:
[14-558]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
W
P
T
I
A
P
F
K
A
G
L
-
I
V
A
G
I
A
L
-
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
--------------
D
D
G
F
-----
G
--
K
TDR
S
---
V
---
L
---
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
----
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
--
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
-
A
L
------
I
T
V
------
V
R
E
G
A
S
I
I
-
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
---
S
K
R
F
R
S
I
--
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
----
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
L
--
A
L
A
F
V
L
Y
A
AS
F
-----
P
S
V
M
D
---
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
------
F
A
-----
I
L
D
S
E
-
Q
E
K
D
EGKR
V
I
D
R
A
T
G
D
L
----
E
F
R
N
V
T
F
T
Y
P
---
G
R
E
V
P
A
-------------
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
---
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-----
N
D
-
T
V
A
N
----------
N
--------
I
A
------------
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
MAYAMD
F
I
N
K
M
D
N
G
L
------
D
------
T
IIGENG
V
------
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
----
S
E
R
A
I
Q
A
A
L
--
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
-----------------------
17
PsiBlast_PDB
61.44
28%
-87
- C1 -
2FF7
1
A:
[16-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
K
P
D
S
-----
P
V
I
-------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
NRS
I
I
D
N
-
I
S
L
A
----------
N
--------
P
G
------------
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
------
I
S
E
L
R
E
G
Y
------
N
------
T
IVGEQG
A
------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
----
S
E
H
V
I
M
R
N
M
H
K
I
C
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
----------------------
8
PsiBlast_PDB
61.43
28%
-96
- C1 -
4S0F
2
?
A:
[431-703]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
A
L
----
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
-------
R
E
D
S
------
D
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
----
G
L
R
K
P
V
-------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
---
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
SGT
V
K
E
N
-
L
C
L
G
NENVD
M
D
E
I
I
K
--------
A
A
------------
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
-------
T
F
L
---
N
E
------
S
------
G
------
A
------
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
-
L
E
D
D
V
-------
T
V
I
I
I
A
H
R
L
S
T
I
-
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
-----------------------
6
PsiBlast_PDB
61.21
28%
-107
- C1 -
4RY2
-
?
A:
[431-703]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
A
L
----
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
------------------------G
D
I
-
E
F
R
N
V
D
F
R
Y
----
G
L
R
K
P
V
-------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
---
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
GT
V
K
E
N
-
L
C
L
G
NENVD
M
D
E
I
I
K
--------
A
A
------------
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
-------
T
F
L
---
N
E
------
S
------
G
------
A
------
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
-
L
E
D
D
V
-------
T
V
I
I
I
A
H
R
L
S
T
I
-
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
-----------------------
18
PsiBlast_PDB
61.16
28%
-85
- C1 -
2PMK
1
A:
[12-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
K
P
D
S
-----
P
V
I
-------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
NRS
I
I
D
N
-
I
S
L
A
----------
N
--------
P
G
------------
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
------
I
S
E
L
R
E
G
Y
------
N
------
T
IVGEQG
A
------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
----
S
E
H
V
I
M
R
N
M
H
K
I
C
K
----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
----------------------
15
PsiBlast_PDB
52.23
31%
-83
- C1 -
5DGX
1
?
A:
[34-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
---
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
-----
D
D
-
T
V
Y
N
----------
N
--------
I
A
FGEVS
E
E
E
V
I
D
-
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
-------
I
N
T
N
I
G
N
-------
N
------
G
------
S
------
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
---------------------
L
E
S
L
T
K
--
S
C
-
T
T
I
V
I
A
H
R
L
S
T
V
-
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
-----------------------