@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2579: (2016-02-09 )
MCPCPHSQAQGETDGEAEWHNAALDFTHAMSYGDYLKLDKVLDAQFPLSPDHNEMLFIIQHQTSELWMKLMLHELRAAREHVKSGKLGPALKMLARVSRIFDQLVHAWAVLATMTPTEYNTIRPYLGQSSGFQSYQYREIEFILGNKNATLLKPHAHRAELLAALEQALHTPSLYDEAIRLMAAQGLPVSQERLARDAAAGTCYEASVEAAWRQVYQAPERYWDLYQLAEKLIDLEDSFRQWRFRHVTTVERIIGFKPGTGGTEGVGYLRSMLDTILFPELWRLRSNL
Atome Classification :
(28 SA)
.........10........20........30........40........-----50-.-----........60........70........-----80-----........90........100.......110.......120.......130.......140...-------------------....150.......160.------......170-----------.......180........190------......--...200.......210-------------------------.......----------------------------------.220.......230.......240.......250......-.260.......270....--...280......-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MCPCPHSQAQGETDGEA
E
W
HN
A
A
L
D
F
T
H
AMSYGD
Y
L
K
L
D
K
V
LDAQFPLS-----P--D-----HN
E
M
L
F
I
I
QHQ
T
S
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
E
H
-----
V
KSGKL
G
P
A
L
K
M
L
A
R
V
S
R
I
F
D
Q
L
V
H
A
W
A
V
L
A
TMTPTEYNTIRPYLGQSSGFQ
S
Y
Q
Y
R
E
I
E
F
I
LG-------------------NKN
A
T
L
LKPH
A
H
R
A
E
L
L
A
------
A
L
E
Q
ALHT
P
-----------
S
L
Y
D
E
A
I
R
-
L
M
A
AQGLPV
S
--------
Q
E
R
L
A
R
--DAAAG
T
C
Y
E
A
S
V
E
A
A
--------------------------
W
R
Q
V
YQ
A
----------------------------------
P
E
R
Y
W
D
L
Y
Q
L
A
E
K
L
I
D
L
E
D
S
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
I
IGFKP-GTGGT
E
G
V
G
Y
L
R
S
M
L
D
T
I
--
L
F
P
E
L
W
R
L
RSNL-----------
31
PsiBlast_CBE
98.57
72%
-113
- C4 -
2NOX
2
T23O_CUPMC
D:
[23-281]
-----------------------------
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
27
PsiBlast_CBE
97.91
72%
-109
- C4 -
2NOX
2
T23O_CUPMC
H:
[23-281]
-----------------------------
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
25
PsiBlast_CBE
97.53
72%
-110
- C4 -
2NOX
2
T23O_CUPMC
J:
[21-281]
---------------------------
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
-----
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
1
PsiBlast_PDB
97.44
72%
-101
- C4 -
2NOX
2
T23O_CUPMC
A:
[21-281]
---------------------------
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
62
HHSearch
97.17
71%
-101
- C4 -
2NOX
2
T23O_CUPMC
A:
[21-281]
---------------------------
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
19
PsiBlast_CBE
97.16
72%
-109
- C4 -
2NOX
6
T23O_CUPMC
P:
[23-281]
-----------------------------
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
20
PsiBlast_CBE
97.15
72%
-107
- C4 -
2NOX
6
T23O_CUPMC
O:
[21-281]
---------------------------
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
-----
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
29
PsiBlast_CBE
97.05
72%
-108
- C4 -
2NOX
2
T23O_CUPMC
F:
[17-281]
-----------------------
M
D
F
A
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
------
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
28
PsiBlast_CBE
97.01
72%
-107
- C4 -
2NOX
2
T23O_CUPMC
G:
[22-281]
----------------------------
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
--
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
33
PsiBlast_CBE
96.87
72%
-108
- C4 -
2NOX
2
T23O_CUPMC
B:
[12-281]
------------------
W
H
G
A
Q
M
D
F
A
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
----
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
32
PsiBlast_CBE
96.55
72%
-110
- C4 -
2NOX
2
T23O_CUPMC
C:
[22-281]
----------------------------
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
------
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
26
PsiBlast_CBE
96.21
72%
-102
- C4 -
2NOX
2
T23O_CUPMC
I:
[23-281]
-----------------------------
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
-
G
T
G
G
T
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
30
PsiBlast_CBE
95.79
72%
-107
- C4 -
2NOX
2
T23O_CUPMC
E:
[21-281]
---------------------------
R
D
M
S
Y
G
D
Y
L
G
L
D
Q
I
L
S
A
Q
H
P
L
S
-----
P
--
D
-----
H
N
E
M
L
F
I
V
Q
H
Q
T
T
E
L
W
M
K
L
M
L
H
E
L
R
A
A
R
-----
D
G
-----
V
K
S
D
Q
L
Q
P
A
F
K
M
L
A
R
V
S
R
I
M
D
Q
L
V
Q
A
W
N
V
L
A
T
M
T
P
P
E
Y
S
A
M
R
P
Y
L
G
A
S
S
G
F
Q
S
Y
Q
Y
R
E
I
E
F
I
L
G
-------------------
N
K
N
A
A
M
L
R
P
H
A
H
R
P
E
H
L
E
------
L
V
E
T
A
L
H
T
P
-----------
S
M
Y
D
E
A
I
R
-
L
M
A
R
R
G
F
Q
I
D
--------
P
E
V
V
E
R
--
D
W
T
Q
P
T
Q
Y
N
A
S
V
E
A
A
--------------------------
W
L
E
V
Y
R
N
----------------------------------
P
S
A
H
W
E
L
Y
E
L
G
E
K
F
V
D
L
E
D
A
F
R
Q
W
R
F
R
H
V
T
T
V
E
R
V
I
G
F
K
R
------
E
G
V
S
Y
L
R
R
M
L
D
V
V
--
L
F
P
E
L
W
K
L
R
T
D
L
-----------
49
PsiBlast_CBE
86.41
46%
-105
- C4 -
3BK9
6
T23O_XANCP
C:
[17-282]
------------------------
D
L
E
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
------
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
50
PsiBlast_CBE
86.05
46%
-97
- C4 -
3BK9
6
T23O_XANCP
B:
[17-282]
------------------------
D
L
E
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
6
PsiBlast_PDB
86.01
46%
-98
- C4 -
3BK9
5
T23O_XANCP
A:
[17-282]
------------------------
D
L
E
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
4
PsiBlast_PDB
85.41
47%
-99
- C4 -
2NW8
4
T23O_XANCP
A:
[19-282]
--------------------------
E
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
44
PsiBlast_CBE
85.34
46%
-105
- C4 -
3BK9
5
T23O_XANCP
H:
[22-282]
-----------------------------
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
-------
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
47
PsiBlast_CBE
85.33
46%
-104
- C4 -
3BK9
4
T23O_XANCP
E:
[23-282]
------------------------------
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
48
PsiBlast_CBE
85.31
46%
-100
- C4 -
3BK9
7
T23O_XANCP
D:
[22-282]
-----------------------------
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
A
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
61
HHSearch
85.21
46%
-99
* C4 *
2NW8
4
T23O_XANCP
A:
[19-282]
--------------------------
E
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
-----
E
PA
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
2
PsiBlast_PDB
84.70
47%
-106
- C4 -
2NW7
2
T23O_XANCP
A:
[21-282]
----------------------------
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
------
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
3
PsiBlast_PDB
84.44
47%
-97
- C4 -
2NW9
3
T23O_XANCP
A:
[20-282]
---------------------------
G
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-
G
T
G
G
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
36
PsiBlast_CBE
84.03
47%
-106
- C4 -
2NW7
2
T23O_XANCP
B:
[21-282]
----------------------------
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
------
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
34
PsiBlast_CBE
83.61
47%
-100
- C4 -
2NW7
1
T23O_XANCP
D:
[21-282]
----------------------------
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
R
-----
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
35
PsiBlast_CBE
83.10
47%
-101
- C4 -
2NW7
2
T23O_XANCP
C:
[21-282]
----------------------------
R
L
T
Y
G
G
Y
L
R
L
D
Q
L
L
S
A
Q
Q
P
L
S
EP---
A
--
H
-----
H
D
E
M
L
F
I
I
Q
H
Q
T
S
E
L
W
L
K
L
L
A
H
E
L
R
A
A
I
-----
V
H
-----
L
Q
R
D
E
V
W
Q
C
R
K
V
L
A
R
S
K
Q
V
L
R
Q
L
T
E
Q
W
S
V
L
E
T
L
T
P
S
E
Y
M
G
F
R
D
V
L
G
P
S
S
G
F
Q
S
L
Q
Y
R
Y
I
E
F
L
L
G
-------------------
N
K
N
P
Q
M
L
Q
V
F
A
Y
D
P
A
G
Q
A
------
R
L
R
E
V
L
E
A
P
-----------
S
L
Y
E
E
F
L
R
-
Y
L
A
R
F
G
H
A
I
P
--------
Q
Q
Y
Q
A
R
--
D
W
T
A
A
H
V
A
D
D
T
L
R
P
V
--------------------------
F
E
R
I
Y
E
N
----------------------------------
T
D
R
Y
W
R
E
Y
S
L
C
E
D
L
V
D
V
E
T
Q
F
Q
L
W
R
F
R
H
M
R
T
V
M
R
V
I
G
F
K
------
S
S
G
V
G
F
L
Q
Q
A
L
A
L
T
--
F
F
P
E
L
F
D
V
R
T
S
V
-----------
52
Fugue
74.94
33%
-101
- C4 -
4HKA
1
T23O_DROME
A:
[3-347]
----------------------------
G
K
I
Y
G
E
Y
L
M
L
D
K
L
L
D
A
Q
C
M
L
S
-----
E
--
E
D
KRPV
H
D
E
H
L
F
I
I
T
H
Q
A
Y
E
L
W
F
K
Q
I
I
F
E
F
D
S
I
R
-----
D
M
L
DAEV
I
D
E
T
K
T
L
E
I
V
K
R
L
N
R
V
V
L
I
L
K
L
L
V
D
Q
V
P
I
L
E
T
M
T
P
L
D
F
M
D
F
R
K
Y
L
A
P
A
S
G
F
Q
S
L
Q
F
R
L
I
E
N
K
L
G
VLTEQRVRYNQKYSDVFSD
E
E
A
R
N
S
I
R
N
S
E
K
D
P
S
L
L
E
------
L
V
Q
R
W
L
E
R
T
PGLEESGFN
F
W
A
K
F
Q
E
S
V
D
-
R
F
L
E
A
Q
V
Q
S
A
M
E
EPV---
E
K
A
K
N
Y
--
R
L
M
D
I
E
K
R
R
E
V
Y
R
S
I
F
D
P
A
V
H
D
A
L
V
R
R
GDRRFS
H
R
A
L
Q
G
A
I
M
I
T
F
Y
R
D
----------------------------------
E
P
R
F
S
Q
P
H
Q
L
L
T
L
L
M
D
I
D
S
L
I
T
K
W
R
Y
N
H
V
I
M
V
Q
R
M
I
G
S
Q
Q
L
G
T
G
G
S
S
G
Y
Q
Y
L
R
S
T
L
S
D
R
YK
V
F
L
D
L
F
N
L
S
T
F
L
IPREA
I
P
P
L
D
E
9
PsiBlast_PDB
72.53
31%
-95
- C4 -
4HKA
1
T23O_DROME
A:
[6-319]
-------------------------------
Y
G
E
Y
L
M
L
D
K
L
L
D
A
Q
C
M
L
S
E
E
D
KR
P
--
V
-----
H
D
E
H
L
F
I
I
T
H
Q
A
Y
E
L
W
F
K
Q
I
I
F
E
F
D
S
I
R
D
M
L
DA
E
V
-----
I
D
E
T
K
T
L
E
I
V
K
R
L
N
R
V
V
L
I
L
K
L
L
V
D
Q
V
P
I
L
E
T
M
T
P
L
D
F
M
D
F
R
K
Y
L
A
P
A
S
G
F
Q
S
L
Q
F
R
L
I
E
N
K
L
G
-------------------
V
L
T
E
Q
R
V
R
Y
N
Q
K
Y
S
D
V
F
S
D
E
E
A
R
N
S
I
R
N
S
E
K
D
P
-----------
S
L
L
E
L
V
Q
R
W
L
E
R
T
P
G
L
E
E
S
GFN
F
W
A
K
F
Q
E
S
V
D
R
F
L
E
A
Q
V
Q
S
A
M
E
E
P
V
E
K
A
K
N
Y
R
L
M
D
I
E
K
----------------
R
R
E
V
Y
R
S
I
F
D
P
A
V
H
D
A
L
V
R
R
GDRRFS
H
R
A
L
Q
G
A
I
M
I
T
F
Y
R
D
E
P
R
F
S
Q
P
H
Q
L
L
T
L
L
M
D
I
D
S
L
I
T
K
W
R
Y
N
H
V
I
M
V
Q
R
M
I
G
S
Q
Q
L
G
T
G
G
S
S
G
Y
Q
Y
L
R
S
T
L
----------------------------