@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2739: (2016-02-10 )
MKFSEKWLRSWANPQVSHDELVARLSMVGLEVDADLPVAGAFSGVVVGEVLSTEQHPDADKLRVCQVSNGSETFQVVCGAPNVRAGLKIPFAMIGAELPDDFKIKKAKLRGVESFGMLCSAKELQISEENAGLLELPADAPVGQDVRTYLELADYTIEVGLTPNRGDCLSLAGLAREVSAIYDVPLAPVAVDAVAAQHDETRPVELAAPAACPRYLGRVIRNVDLSRPTPLWMVERLRRSDIRSIDPVVDVTNYVMIELGQPMHAFDLAEINGGVRVRMAEDGEKLVLLDGQEITLRADTLVIADHQRALAIAGVMGGEHSGVSDSTRDLFLEAAFFDTIALAGKARSYGLHTDSSHRFERGVDSQLARKAMERATRLILDIVGGEPGPIVEQVSEAHLPKVAPITLRAERVTQMLGMPLDAAEIVRLLQALELTVVADGEGQWSVGVPSHRFDISLEVDLIEELARLYGYNRLPVRYPQARLAPNNKPEARAALPLLRRLLVARGYQEAITFSFIDPALFELFDPGTQPLTLANPISADMAAMRSSLWPGLVKALQHNLNRQQSRVRLFESGLRFVGQLEGLKQEAMLAGAICGKRLPEGWANGRDGVDFFDAKADVEAVLASAGALGDFSFVPGEHPALHPGQTARIEREGRLVGYLGALHPELAKKLDLEQPVFLFELLLAEVVDGHLPKFRELSRFPEVRRDLALLVDQDVPAQDILTQIRAAAGEWLTDLRLFDVYHGKGIDPHRKSLAVGLTWQHPSRTLNDDEVNSTTQNIVTSLEERFNATLRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.......-.70-..-......80........90........100........110.......120......-------.------130.......140........150.......160.......170.......180.......190....--...200--......----.210.......220...-....230.......240.......250.......260.......270.-.-.....280.......290.......300..----.....310.......320.......330.......340.......350.......360.......370.......380.......390.......400..-......410.......420.......430.......440-.......450.......460.......470.......480.-.....-------..490.......500.......510.......520.....-..530........540.......550.......560..-.....570.......580--.-.....-..590.......600.......610.......620.......630.......640.......650.......660.......670.......680--........690.........700.......710.......720.......730.......740.......750.......760.......770.......780.......790
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
F
S
E
K
W
L
R
SWANPQV
S
H
D
E
L
V
A
R
L
S
MV
G
L
E
VDADLPVAGA
F
S
G
V
V
V
G
E
V
LSTEQHPDAD
K
L
R
V
C
QVS-NGS-
E
T
-
F
Q
V
V
CGAPNVRAGLKI
P
F
A
M
IGAELPD-DF
K
I
K
K
A
K
LR
G
V
E
S
F
G
M
LCSA
K
E
L
Q
ISE-------E------NAG
L
L
ELPADA-PV
G
Q
D
V
R
T
Y
L
E
LA
D
Y
T
I
E
V
GLTPNRG
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
YDVPLA
P
V
A
V
D
A
V
AA--QHDETR--P
V
E
LAA----P
A
A
C
P
R
Y
L
G
R
V
I
R
NVDL-SRPT
P
L
W
M
V
E
R
L
R
R
SDIRSIDPVVDVT
N
Y
V
M
I
ELGQPM
H
A
F
D
L
A
EING-
G
-
V
R
V
R
MAEDG
E
K
L
V
L
LDG
Q
E
I
T
L
R
A
D
T
L
V
I
A----DHQ
R
A
L
A
I
A
GVMGGEHSGVSD
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
LAGKARSYGLHTDS
S
H
R
F
ERG
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
VGGEP
G
P
I
V
E
Q
V
S
E
AHLPK-VA-
P
I
T
L
R
A
E
R
V
T
Q
M
LGMPL
D
A
A
E
I
V
R
L
L
Q
AL
E
L
T
V
V
ADGEG-
Q
W
SVGVPSH
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
YGYNRLPVRYP
Q
-
A
R-LAPNN-------KP
E
A
R
A
A
L
P
L
L
R
R
L
L
V
ARGYQ
E
A
I
T
F
SFI
D
P
A
L
F
E
LFDPG-TQ
P
-
L
T
LANPI
S
A
D
M
A
A
M
R
S
SL
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
CGKRLPEGWANGRDGVDFFDAK
A
D
V
E
A
V
L
A
SAGALGDFSFVPGEHPALHPGQT
A
R
I
EREG
R
L
V
G
Y
L
G
AL
H
P
E
L
A
K
KLDLEQ
P
V
F
L
F
E
L
---
L
L
A
E
V
VDGH--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
VDQDV
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
YHGKGIDP
H
R
K
S
L
A
V
G
L
T
WQHPSRTLN
D
D
EVN
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
TLRK
3
PsiBlast_PDB
96.50
100%
-118
- C1 -
4P73
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
S
-
E
T
-
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
-------
E
------
N
A
G
L
L
E
L
P
A
D
A
-
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
--
Q
H
D
E
T
R
--
P
V
E
L
A
A
----
P
A
A
C
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
L
P
K
-
V
A
-
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
-
A
R
-
L
A
P
N
N
-------
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
-
L
T
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
C
G
K
R
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
---
L
L
A
E
V
V
D
G
H
--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-
2
PsiBlast_PDB
96.44
100%
-117
- C1 -
4P72
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
S
-
E
T
-
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
-------
E
------
N
A
G
L
L
E
L
P
A
D
A
-
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
--
Q
H
D
E
T
R
--
P
V
E
L
A
A
----
P
A
A
C
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
L
P
K
-
V
A
-
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
-
A
R
-
L
A
P
N
N
-------
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
-
L
T
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
C
G
K
R
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
---
L
L
A
E
V
V
D
G
H
--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-
4
PsiBlast_PDB
96.43
100%
-118
- C1 -
4P74
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
S
-
E
T
-
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
-------
E
------
N
A
G
L
L
E
L
P
A
D
A
-
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
--
Q
H
D
E
T
R
--
P
V
E
L
A
A
----
P
A
A
C
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
L
P
K
-
V
A
-
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
-
A
R
-
L
A
P
N
N
-------
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
-
L
T
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
C
G
K
R
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
---
L
L
A
E
V
V
D
G
H
--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-
5
PsiBlast_PDB
96.30
100%
-118
- C1 -
4P75
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
S
-
E
T
-
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
-------
E
------
N
A
G
L
L
E
L
P
A
D
A
-
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
--
Q
H
D
E
T
R
--
P
V
E
L
A
A
----
P
A
A
C
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
L
P
K
-
V
A
-
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
-
A
R
-
L
A
P
N
N
-------
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
-
L
T
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
C
G
K
R
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
---
L
L
A
E
V
V
D
G
H
--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-
1
PsiBlast_PDB
95.91
100%
-117
- C1 -
4P71
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
S
-
E
T
-
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
-------
E
------
N
A
G
L
L
E
L
P
A
D
A
-
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
--
Q
H
D
E
T
R
--
P
V
E
L
A
A
----
P
A
A
C
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
L
P
K
-
V
A
-
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
-
A
R
-
L
A
P
N
N
-------
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
-
L
T
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
-
S
R
V
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
---
G
-
L
K
Q
E
A
-
M
L
A
G
A
I
C
G
K
R
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
---
L
L
A
E
V
V
D
G
H
--
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-
6
PsiBlast_PDB
76.92
51%
-104
- C1 -
3PCO
-
SYFB_ECOLI
B:
[1-794]
M
K
F
S
E
L
W
L
R
E
W
V
N
P
A
I
D
S
D
A
L
A
N
Q
I
T
M
A
G
L
E
V
D
G
V
E
P
V
A
G
S
F
H
G
V
V
V
G
E
V
V
E
C
A
Q
H
P
N
A
D
K
L
R
V
T
K
V
N
V
G
G
D
-
R
L
-
L
D
I
V
C
G
A
P
N
C
R
Q
G
L
R
V
A
V
A
T
I
G
A
V
L
P
G
-
D
F
K
I
K
A
A
K
L
R
G
E
P
S
E
G
M
L
C
S
F
S
E
L
G
I
S
D
-------
D
------
H
S
G
I
I
E
L
P
A
D
A
-
P
I
G
T
D
I
R
E
Y
L
K
L
D
D
N
T
I
E
I
S
V
T
P
N
R
A
D
C
L
G
I
I
G
V
A
R
D
V
A
V
L
N
Q
L
P
L
V
Q
P
E
I
V
P
V
G
A
--
T
I
D
D
T
L
--
P
I
T
V
E
A
----
P
E
A
C
P
R
Y
L
G
R
V
V
K
G
I
N
V
-
K
A
P
T
P
L
W
M
K
E
K
L
R
R
C
G
I
R
S
I
D
A
V
V
D
V
T
N
Y
V
L
L
E
L
G
Q
P
M
H
A
F
D
K
D
R
I
E
G
-
G
-
I
V
V
R
M
A
K
E
G
E
T
L
V
L
L
D
G
T
E
A
K
L
N
A
D
T
L
V
I
A
----
D
H
N
K
A
L
A
M
G
G
I
F
G
G
E
H
S
G
V
N
D
E
T
Q
N
V
L
L
E
C
A
F
F
S
P
L
S
I
T
G
R
A
R
R
H
G
L
H
T
D
A
S
H
R
Y
E
R
G
V
D
P
A
L
Q
H
K
A
M
E
R
A
T
R
L
L
I
D
I
C
G
G
E
A
G
P
V
I
D
I
T
N
E
A
T
L
P
K
-
R
A
-
T
I
T
L
R
R
S
K
L
D
R
L
I
G
H
H
I
A
D
E
Q
V
T
D
I
L
R
R
L
G
C
E
-
V
T
E
G
K
D
-
E
W
Q
A
V
A
P
S
W
R
F
D
M
E
I
E
E
D
L
V
E
E
V
A
R
V
Y
G
Y
N
N
I
P
D
E
P
V
Q
-
A
S
-
L
I
M
G
T
-------
H
R
E
A
D
L
S
L
K
R
V
K
T
L
L
N
D
K
G
Y
Q
E
V
I
T
Y
S
F
V
D
P
K
V
Q
Q
M
I
H
P
G
-
V
E
A
-
L
L
L
P
S
P
I
S
V
E
M
S
A
M
R
L
S
L
W
T
G
L
L
A
T
V
V
Y
N
Q
N
R
Q
Q
-
N
R
V
R
I
F
E
S
G
L
R
F
V
P
D
T
Q
APL
G
-
I
R
Q
D
L
-
M
L
A
G
V
I
C
G
N
R
Y
E
E
H
W
N
L
A
K
E
T
V
D
F
Y
D
L
K
G
D
L
E
S
V
L
D
L
T
G
K
L
N
E
V
E
F
R
A
E
A
N
P
A
L
H
P
G
Q
S
A
A
I
Y
L
K
G
E
R
I
G
F
V
G
V
V
H
P
E
L
E
R
K
L
D
L
N
G
R
T
L
V
F
E
L
---
E
W
N
K
L
A
D
R
V
--
V
P
Q
A
R
E
I
S
R
F
P
A
N
R
R
D
I
A
V
V
V
A
E
N
V
P
A
A
D
I
L
S
E
C
K
K
V
G
V
N
Q
V
V
G
V
N
L
F
D
V
Y
R
G
K
G
V
A
E
G
Y
K
S
L
A
I
S
L
I
L
Q
D
T
S
R
T
L
E
E
E
E
I
A
A
T
V
A
K
C
V
E
A
L
K
E
R
F
Q
A
S
L
R
-
45
HHSearch
76.86
52%
-103
- C1 -
3PCO
-
SYFB_ECOLI
B:
[1-795]
M
K
F
S
E
L
W
L
R
E
W
V
N
P
A
I
D
S
D
A
L
A
N
Q
I
T
M
A
G
L
E
V
D
G
V
E
P
V
A
G
S
F
H
G
V
V
V
G
E
V
V
E
C
A
Q
H
P
N
A
D
K
L
R
V
T
K
V
N
-
V
G
G
D
R
L
-
L
D
I
V
C
G
A
P
N
C
R
Q
G
L
R
V
A
V
A
T
I
G
A
V
L
P
G
-
D
F
K
I
K
A
A
K
L
R
G
E
P
S
E
G
M
L
C
S
F
S
E
L
G
I
S
D
-------
D
------
H
S
G
I
I
E
L
P
A
D
A
-
P
I
G
T
D
I
R
E
Y
L
K
L
D
D
N
T
I
E
I
S
V
T
P
N
R
A
D
C
L
G
I
I
G
V
A
R
D
V
A
V
L
N
Q
L
P
L
V
Q
P
E
I
V
P
V
G
A
--
T
I
D
D
T
L
--
P
I
T
V
E
A
----
P
E
A
C
P
R
Y
L
G
R
V
V
K
G
I
N
V
K
A
-
P
T
P
L
W
M
K
E
K
L
R
R
C
G
I
R
S
I
D
A
V
V
D
V
T
N
Y
V
L
L
E
L
G
Q
P
M
H
A
F
D
K
D
R
I
E
G
-
G
-
I
V
V
R
M
A
K
E
G
E
T
L
V
L
L
D
G
T
E
A
K
L
N
A
D
T
L
V
I
A
----
D
H
N
K
A
L
A
M
G
G
I
F
G
G
E
H
S
G
V
N
D
E
T
Q
N
V
L
L
E
C
A
F
F
S
P
L
S
I
T
G
R
A
R
R
H
G
L
H
T
D
A
S
H
R
Y
E
R
G
V
D
P
A
L
Q
H
K
A
M
E
R
A
T
R
L
L
I
D
I
C
G
G
E
A
G
P
V
I
D
I
T
N
E
A
T
L
P
K
-
R
A
-
T
I
T
L
R
R
S
K
L
D
R
L
I
G
H
H
I
A
D
E
Q
V
T
D
I
L
R
R
L
G
C
E
V
T
E
-
G
K
D
-
E
W
Q
A
V
A
P
S
W
R
F
D
M
E
I
E
E
D
L
V
E
E
V
A
R
V
Y
G
Y
N
N
I
P
D
E
P
V
Q
-
A
S
-
L
I
M
G
T
-------
H
R
E
A
D
L
S
L
K
R
V
K
T
L
L
N
D
K
G
Y
Q
E
V
I
T
Y
S
F
V
D
P
K
V
Q
Q
M
I
H
P
G
-
V
E
A
-
L
L
L
P
S
P
I
S
V
E
M
S
A
M
R
L
S
L
W
T
G
L
L
A
T
V
V
Y
N
Q
N
R
Q
Q
-
N
R
V
R
I
F
E
S
G
L
R
F
V
P
D
T
Q
APL
G
-
I
R
Q
D
L
-
M
L
A
G
V
I
C
G
N
R
Y
E
E
H
W
N
L
A
K
E
T
V
D
F
Y
D
L
K
G
D
L
E
S
V
L
D
L
T
G
K
L
N
E
V
E
F
R
A
E
A
N
P
A
L
H
P
G
Q
S
A
A
I
Y
L
K
G
E
R
I
G
F
V
G
V
V
H
P
E
L
E
R
K
L
D
L
N
G
R
T
L
V
F
E
L
---
E
W
N
K
L
A
D
R
V
--
V
P
Q
A
R
E
I
S
R
F
P
A
N
R
R
D
I
A
V
V
V
A
E
N
V
P
A
A
D
I
L
S
E
C
K
K
V
G
V
N
Q
V
V
G
V
N
L
F
D
V
Y
R
G
K
G
V
A
E
G
Y
K
S
L
A
I
S
L
I
L
Q
D
T
S
R
T
L
E
E
E
E
I
A
A
T
V
A
K
C
V
E
A
L
K
E
R
F
Q
A
S
L
R
D
21
PsiBlast_CBE
74.89
35%
-103
- C1 -
2RHS
1
SYFB_STAHJ
D:
[1-799]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
------
K
L
N
I
C
Q
V
D
-
I
G
E
-
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
G
-
G
I
K
I
K
R
A
K
--
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
NVVP-------------
I
F
V
F
P
T
E
V
-
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
--
S
E
S
A
T
N
E
L
S
V
T
I
D
N
----
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
I
--
E
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
-
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
--
V
L
Q
D
R
V
S
S
G
D
L
G
S
F
V
T
-
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
K
G
E
--
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
P
V
F
G
E
-
V
T
S
G
E
-------
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
-
E
R
P
T
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
-
K
D
V
R
L
Y
E
I
G
R
V
F
F
G
N
G
E
---
G
E
L
P
D
E
V
E
Y
L
S
G
I
L
T
G
E
Y
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
A
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
G
G
A
G
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
R
-
T
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
--
I
-
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
G
E
H
L
E
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
Q
-
G
A
T
I
--
7
PsiBlast_PDB
73.69
35%
-102
- C1 -
2RHS
1
SYFB_STAHJ
B:
[1-800]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
K
-------
N
I
C
Q
V
D
-
I
G
E
-
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
G
-
G
I
K
I
K
R
A
K
---
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
NVVPKAY
E
------
N
-
G
I
F
V
F
P
T
E
V
-
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
--
S
E
S
A
T
N
E
L
S
V
T
I
D
N
----
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
I
--
E
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
-
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
--
V
L
Q
D
R
V
S
S
G
D
L
G
S
F
V
T
-
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
K
G
E
--
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
P
V
F
G
E
-
V
T
S
G
E
-------
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
-
E
R
P
T
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
-
K
D
V
R
L
Y
E
I
G
R
V
F
F
G
N
G
E
---
G
E
L
P
D
E
V
E
Y
L
S
G
I
L
T
G
E
Y
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
A
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
G
G
A
G
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
R
-
T
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
--
I
-
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
G
E
H
L
E
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
----
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
Q
-
G
A
T
I
R
-
8
PsiBlast_PDB
73.47
34%
-101
- C1 -
2RHQ
-
SYFB_STAHJ
B:
[1-789]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
K
G
S
G
----
N
I
C
Q
V
D
-
I
G
E
-
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
G
-
G
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
NVVPKAY
E
------
N
-
G
I
F
V
F
P
T
E
V
-
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
--
S
E
S
A
T
N
E
L
S
V
T
I
D
N
----
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
I
--
E
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
-
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
--
V
L
Q
D
R
V
S
S
G
D
L
G
S
F
V
T
-
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
K
G
E
--
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
P
V
F
G
E
-
V
T
S
G
E
-------
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
-
E
R
P
T
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
-
K
D
V
R
L
Y
E
I
G
R
V
F
F
G
N
G
E
---
G
E
L
P
D
E
V
E
Y
L
S
G
I
L
T
G
E
Y
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
A
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
R
-
T
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
--
I
-
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
---------
47
HHSearch
72.66
34%
-101
- C1 -
2RHQ
-
SYFB_STAHJ
B:
[1-795]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
K
G
S
G
----
N
I
C
Q
V
D
-
I
G
E
E
E
P
-
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
G
-
G
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
-------
N
VVPKAY
E
N
G
I
F
V
F
P
T
E
V
-
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
SE
S
A
T
N
E
L
--
S
V
T
I
D
N
----
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
I
-
E
-
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
-
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
S
S
G
D
L
-
G
S
F
-
V
T
-
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
-
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
P
V
-
F
G
E
V
T
S
G
E
-------
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
-
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
-
K
D
V
R
L
Y
E
I
G
R
V
F
F
G
N
G
E
GE-
L
-
P
D
E
V
E
-
Y
L
S
G
I
L
T
G
E
Y
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
A
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
-
R
T
Y
V
F
E
L
---
N
Y
D
A
M
M
Q
V
A
VG
Y
I
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
E
-
G
A
T
I
--
9
PsiBlast_PDB
71.61
37%
-95
- C1 -
1PYS
1
SYFB_THET8
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
V
ED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
14
PsiBlast_PDB
71.14
37%
-93
- C1 -
2AKW
2
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
VED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
16
PsiBlast_PDB
71.08
37%
-94
- C1 -
2AMC
3
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
VED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
15
PsiBlast_PDB
70.98
37%
-95
- C1 -
2ALY
2
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
VED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
13
PsiBlast_PDB
70.94
37%
-93
- C1 -
1JJC
2
SYFB_THET8
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
VED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
19
PsiBlast_PDB
70.20
37%
-91
- C1 -
4TVA
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
VED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
12
PsiBlast_PDB
70.13
37%
-94
- C1 -
1B70
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
V
ED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
--
E
G
E
G
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
-
L
L
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
-----
V
G
R
V
F
---
R
-
E
R
E
E
T
-
H
L
A
G
L
L
F
G
E
G
V
G
L
P
W
A
K
E
R
L
S
-
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
A
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
-
P
P
V
H
L
F
E
L
---
R
L
P
-
L
P
D
K
P
--
L
-
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-------
10
PsiBlast_PDB
70.05
37%
-94
- C1 -
1B7Y
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
--
E
A
H
P
I
P
G
T
R
L
K
R
L
V
L
-
D
A
G
-
R
T
-
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
-------
Y
------
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
-----
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
--
P
L
P
F
A
L
K
V
ED
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
---
V
A
E
A
L
L
E
A
G
S
P
K
-
P
P
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
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I
A
I
L
K
R
L
G
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V
--
E
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G
P
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Y
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P
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H
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L
D
L
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L
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D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
-
F
F
-
P
A
P
D
N
RGVE
A
P
Y
R
K
E
Q
R
-----
L
R
E
V
L
S
G
L
G
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V
Y
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M
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L
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L
D
L
D
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A
L
L
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-----
V
G
R
V
F
---
R
-
E
R
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T
-
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L
A
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L
L
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L
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--
A
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---
R
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P
-
L
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--
L
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V
A
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A
L
R
A
R
-------
18
PsiBlast_PDB
69.75
37%
-92
- C1 -
3TEH
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
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W
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-------
Y
------
G
G
G
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--
L
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--
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-------