@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2987: (2016-02-12 )
MNDKSVLSCRNLSKSYDEGPQSVQVLSGVELNLLPGERVAIVGSSGSGKSTLLNMLGGLDTPSAGSVWLAGEELSALNETARGLLRNRALGFVYQFHHLLPEFTALENVCMPLLIGRTPIAEARQRAAELLERVGLGHRLSHKPAELSGGERQRVAIARALVNRPQLVLLDEPTGNLDQHTAQGIQELMLELSRSLQTSFLVVTHDLQLAGHMDRILRLEEGRLIAA
Atome Classification :
(47 SA)
.........10........-20........30........40........50........60........70........80.......-.90........100---........110..--..---...---.120.......130......-.140..-......150.......160.......170.......180.......190.......200....-..-.210..-......220.....---------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MND
K
S
V
L
S
C
R
N
L
S
K
SYDEG-PQ
S
V
Q
V
LS
G
V
E
L
NLLPG
E
R
V
A
I
V
GSSGS
G
K
S
T
L
L
N
M
LGGLDTPSAG
S
V
W
LA
G
E
E
L
S
A
L
N
E
T
A
R
G
L
L
R
N
R
-
A
L
G
F
V
Y
Q
F
H
H
LL
P
----
E
F
T
A
L
E
N
V
C
M
-
P
L
--LI---GRT---
P
I
A
E
A
R
Q
R
A
A
E
L
L
E
RVGLGH-RLS-HK-PAELSGG
E
R
Q
R
V
A
I
A
R
A
L
VNRP
Q
L
V
L
L
DEPTGN
L
D
Q
H
T
A
Q
G
I
Q
E
L
M
L
E
L
S
R
SLQ
T
S
F
L
V
V
T
H
D
-
L
Q
-
L
A
-
G
H
M
-
D
R
I
L
R
LEEG
R
L
IAA---------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
94.51
47%
-119
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[4-219]
-----
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
-
K
L
G
F
V
F
Q
F
H
Y
L
I
P
----
E
L
T
A
L
E
N
V
I
V
-
P
M
--
L
K
---
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
S
-
R
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.46
47%
-115
- C1 -
2PCL
12
LOLD_AQUAE
A:
[4-219]
-----
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
-
K
L
G
F
V
F
Q
F
H
Y
L
I
P
----
E
L
T
A
L
E
N
V
I
V
-
P
M
--
L
K
---
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
S
-
R
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
----------------------------------------------------------------------------------------------------------------------
117
HHSearch
93.67
48%
-114
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-219]
---
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
-----
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
-
K
L
G
F
V
F
Q
F
H
Y
L
I
P
----
E
L
T
A
L
E
N
V
I
V
-
P
M
--
L
K
---
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
S
-
R
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.07
47%
-116
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[4-219]
-----
I
L
R
A
E
N
I
K
K
V
I
-----
R
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
-
K
L
G
F
V
F
Q
F
H
Y
L
I
P
----
E
L
T
A
L
E
N
V
I
V
-
P
M
--
L
K
---
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
-
K
L
S
-
R
K
-
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
-
L
A
-
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.68
41%
-111
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
-----
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
KYR
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.05
41%
-111
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
------
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
K
YR
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.93
41%
-114
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
-----
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
KYR
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.40
40%
-118
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
-----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
KYR
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.72
40%
-114
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
-----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
KYR
G
A
M
---
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
F
A
N
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
------------------------------------------------------------------------------------------------------------------------
120
HHSearch
88.45
40%
-111
- C1 -
3TIF
7
Y796_METJA
A:
[1-225]
-----
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
-
K
I
G
F
V
F
Q
Q
F
N
L
I
P
----
L
L
T
A
L
E
N
V
E
L
-
P
L
--
I
F
---
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
-
H
K
-
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
-
V
A
-
R
F
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
R
----------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.09
39%
-119
- C1 -
4U00
3
?
A:
[3-217]
----
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
----
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
---
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.53
39%
-113
- C1 -
4U02
1
?
A:
[2-217]
---
E
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
----
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
---
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.41
39%
-112
- C1 -
4U02
1
?
B:
[2-217]
---
E
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
----
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
---
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
84.03
39%
-112
- C1 -
4U02
1
?
D:
[2-217]
---
E
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
----
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
---
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.95
39%
-118
- C1 -
4U02
1
?
C:
[2-217]
---
E
P
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
----
H
M
T
V
L
E
N
V
T
L
A
P
M
--
R
V
---
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
-
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
-----------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.03
38%
-96
- C1 -
1OXV
7
?
A:
[6-220]
--------
V
K
N
V
S
K
V
F
K
K
G
---
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
-
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
----
N
L
T
A
F
E
N
I
A
F
-
P
L
--
T
N
---
M
K
M
---
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
-
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
-
I
F
-
A
I
A
-
D
R
V
G
V
L
V
K
G
K
L
V
-----------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.35
38%
-97
- C1 -
1OXU
13
?
C:
[6-220]
--------
V
K
N
V
S
K
V
F
K
K
G
---
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
-
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
----
N
L
T
A
F
E
N
I
A
F
-
P
L
--
T
N
---
M
K
M
---
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
-
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
-
I
F
-
A
I
A
-
D
R
V
G
V
L
V
K
G
K
L
V
-----------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
79.69
36%
-105
- C1 -
2OUK
1
?
C:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
124
Fugue
79.63
36%
-110
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
----
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
-
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
--
I
G
M
I
F
Q
H
F
N
L
L
S
----
S
R
T
V
F
G
N
V
A
L
-
P
L
--
E
L
---
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
-
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
-
V
V
-
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
DTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
12
PsiBlast_PDB
79.61
38%
-96
- C1 -
1OXU
7
?
A:
[6-220]
--------
V
K
N
V
S
K
V
F
K
K
G
---
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
-
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
----
N
L
T
A
F
E
N
I
A
F
-
P
L
--
T
N
---
M
K
M
---
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
-
H
F
-
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
-
I
F
-
A
I
A
-
D
R
V
G
V
L
V
K
G
K
L
V
-----------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
78.84
36%
-112
- C1 -
2OLK
1
?
D:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
78.78
36%
-107
- C1 -
3C41
3
?
K:
[3-217]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
77.87
36%
-107
- C1 -
2OLK
2
?
B:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
77.80
36%
-107
- C1 -
2OLK
1
?
C:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
77.43
36%
-108
- C1 -
2Q0H
4
?
A:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
77.37
36%
-108
- C1 -
2OLK
1
?
A:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.24
36%
-107
- C1 -
3C41
3
?
J:
[3-217]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
77.07
36%
-109
- C1 -
3C4J
3
?
A:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.06
36%
-110
- C1 -
2OLJ
4
?
A:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.16
36%
-114
- C1 -
3C4J
4
?
B:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.89
36%
-109
- C1 -
2Q0H
4
?
B:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
75.32
36%
-103
- C1 -
2OLJ
3
?
B:
[24-238]
-----
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
E
E
--
V
G
M
V
F
Q
R
F
N
L
F
P
----
H
M
T
V
L
N
N
I
T
L
A
P
M
--
K
V
---
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
-
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.92
37%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[3-218]
----
A
A
L
H
I
G
H
L
S
K
S
F
-----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
L
P
--
V
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
----
H
L
T
V
Y
R
N
I
A
Y
-
G
L
--
G
N
---
G
K
G
---
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
-
R
Y
-
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
-
R
E
-
E
A
L
Q
Y
A
-
D
R
I
A
V
M
K
Q
G
R
I
L
-----------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.70
37%
-102
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[3-223]
----
A
A
L
H
I
G
H
L
S
K
S
F
-----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
L
P
--
V
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
----
H
L
T
V
Y
R
N
I
A
Y
-
G
L
--
G
N
---
G
K
G
---
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
-
R
Y
-
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
-
R
E
-
E
A
L
Q
Y
A
-
D
R
I
A
V
M
K
Q
G
R
I
L
-----------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.61
37%
-114
- C1 -
4YMU
2
?
A:
[13-215]
----------------------
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
----
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
---
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.44
37%
-112
- C1 -
4YMU
2
?
J:
[13-215]
----------------------
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
----
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
---
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
71.51
37%
-112
- C1 -
4YMV
1
?
A:
[13-215]
----------------------
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
----
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
---
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.43
37%
-110
- C1 -
4YMV
1
?
J:
[13-215]
----------------------
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
----
H
L
T
A
I
E
N
I
T
L
A
P
V
--
K
V
---
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
-
Q
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
-
M
V
V
V
T
H
E
-
M
G
-
F
A
-
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.83
31%
-88
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-226]
------
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
Q
V
-
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
----
E
-
T
V
F
K
D
I
A
F
G
P
S
--
N
L
---
G
L
S
---
E
-
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
-
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
-
M
E
D
I
A
-
R
I
A
-
D
K
I
I
V
M
N
R
G
K
I
------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
67.32
31%
-92
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-226]
------
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
Q
V
-
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
----
E
-
T
V
F
K
D
I
A
F
G
P
S
--
N
L
---
G
L
S
---
E
-
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
-
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
-
M
E
D
I
A
-
R
I
A
-
D
K
I
I
V
M
N
R
G
K
I
------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
66.12
32%
-102
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RSII
D
N
I
S
L
A
N
P
G
M
-
S
V
EK
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
65.84
32%
-101
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RS
I
I
D
N
I
S
L
A
N
P
G
M
-
S
V
E
K
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
64.99
32%
-103
- C1 -
2FGK
2
D:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RSII
D
N
I
S
L
A
N
P
G
M
-
S
V
EK
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
64.90
32%
-100
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RSII
D
N
I
S
L
A
N
P
G
M
-
S
V
EK
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
63.22
32%
-108
- C1 -
2FFB
1
A:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RS
I
I
D
N
I
S
L
A
N
P
G
M
-
S
V
E
K
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
62.03
32%
-109
- C1 -
2PMK
1
A:
[4-218]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RS
I
I
D
N
I
S
L
A
N
P
G
M
-
S
V
E
K
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.28
32%
-110
- C1 -
2FF7
1
A:
[8-222]
------
I
T
F
R
N
I
R
F
R
Y
K
---
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
---
W
L
R
-
R
-
Q
V
G
V
V
L
Q
D
N
V
L
L
N
RS
I
I
D
N
I
S
L
A
N
P
G
M
-
S
V
E
K
V
I
---
Y
A
A
---
K
L
A
G
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
T
-
I
V
G
-
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
--
R
T
V
I
I
I
A
H
R
-
L
S
-
T
V
-
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----------------------------------------------------------------------------------------------------------------------