@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3025: (2016-02-13 )
MTSAWNEEWRRRRLPALAGQEWDLIVVGGGISGAGILREAARRGWRCLLLEQRDFAWGTSSRSSKMVHGGLRYIAKGQWRLTRDSVRERQRLLGEAPGLVEPLSFVMAHYRGGFPGPRLFGGLLSVYDALAGRRNHRFYDAAALRYLAPGLKEQRLLGGTRFFDAVTDDARLVLRVLAEARHDGGEAFNGMRVRELLREGGQVVGLRAEDRESGELFDFRCRALALATGAWADELRQPGGSEHIRPLRGSHLLLPAWRLPVAHAFSFMHATDRRPVFVFPWEGATVVGTTDLDHRDGLGEDARISRAELDYLLAACAQQFPAAAIEARDVLSTWAGVRPVVSSGDDSGKPSDEKREHVLWREPGCVTLAGGKLTTFRPLAVEVLQACAPLLGRTVTDDGAAVFGACEGPLIDGLGSGQRRRLAGRYGRDLVRLKRLVDTLGTDCVGASETLWAELAFAAEAEMVLHLDDLLLRRTRLGLLLPGGGAAYLPRIRALCQARLGWDDPRWEREQQAYLDLWRRHYSLPV
Atome Classification :
(20 SA)
.........10......-..20........30........40..-..-.-...50.-.-......60........70....-.-...80........90....-.---.-.-.100---------.......110...---....120.-----......130-.---..--....--.140.....--..150...-----....160-..-.....170.......180.......190.......200.......210.......220.......230.....------.-.----240---...----...---..250.......260.....-..270-........280........290.......300.......310.......320.......330.......340------..------......350.......-.-------.--360-.-.---.....370-.---........380.......390-..-------.-------.---.....400.---......--------------410-------------..---------.......420----.........430....-------.--..440..---.....450.......460.......470.......480.......490.......500.......510.......520....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTS
A
W
N
E
E
W
R
R
RRLPAL-AGQ
E
W
D
L
I
V
VGGGI
S
G
A
G
I
L
R
E
A
A
RR-G
W
-
R
-
C
L
L
L
EQ-R-DFAWGTSSRSS
K
M
V
H
G
G
L
R
Y
IA-K-G
Q
W
R
L
T
R
D
S
V
R
E
R
Q
R
L
LGE-A---P-G-
L
V
E
P
---------
L
S
F
V
M
A
H
Y
RGGFP---
G
P
R
L
F
G
G
L
-----
L
S
V
Y
D
A
L
A--G---RR--NHR
F
--
Y
D
A
A
A
L
R
Y
L--APG
L
K
E
Q
R
-----LLGGT
R
F
-
F
D
-AVTD
D
A
R
L
V
L
R
V
L
A
E
ARHDGGEAFN
G
M
R
V
R
E
L
L
REGG
Q
V
V
G
L
RAEDRESGE
L
F
D
F
R
C
R
A
L
A
LATG
A
W
A
D
E
L
RQ------P-G----GS----EHI----RPL---RGS
H
L
L
L
P
A
W
R
L
P
V
A
H
A
F
S
F
-
M
HA-T-DRR
P
V
F
V
F
PW-E
G
A
T
V
V
GTTDLDHRDGLGEDARI
S
R
A
E
L
D
Y
L
L
A
A
C
A
Q
QFP
A
A
A
I
E
A
R
D
V
L
S
T
W
AGVRPVV-------SS------GDDSGKP--S
D
E
KRE
H
-
V
-------
L
--WRE-P-
G
---
C
V
T
LAG---G---KL
T
T
F
R
P
L
A
V
E
V
L
Q
A
C
A
P
L
---LG-------R-------T---VTDDG
A
A
V
F---GACEGP--------------L---------------ID---------GLGS
G
Q
R
R
------
R
L
A
G
R
Y
G
R
D
L
V
R
L
K
R
L
-------
V
--
D
T
LGTDC---VGA
S
E
T
L
W
A
E
L
A
F
AAE
A
E
M
V
L
H
L
D
D
L
L
L
R
R
TRL
G
L
L
LPGG
G
A
A
Y
L
P
R
I
R
A
L
C
Q
A
RLGWDDP
R
W
E
R
E
Q
Q
A
Y
L
D
L
W
R
R
HYSLPV
91
HHSearch
90.51
31%
-87
- C1 -
2RGH
2
?
A:
[17-563]
-----
S
N
K
T
R
Q
D
S
I
Q
K
M
-
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
-
G
I
-
K
-
T
G
L
I
E
M
-
Q
-
D
F
A
E
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
-
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
-
A
---
P
-
H
-
I
P
K
P
---------
D
P
M
L
L
P
I
Y
E
D
E
G
A
TTF
N
M
F
S
V
K
V
A
-----
M
D
L
Y
D
K
L
A
--
N
VTG
T
K
Y-
E
N
Y
T
--
L
T
P
E
E
V
L
E
R
--
E
P
F
L
K
K
E
G
-----
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
G
D
Q
I
V
G
V
K
A
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
------
L
-
N
FTRP
V
S
----
P
K
M
----
R
P
T
---
K
G
I
H
L
V
V
D
A
K
K
L
P
V
P
Q
P
T
Y
F
-
D
T
G
K
Q
-
D
G
R
M
V
F
A
I
P
R
-
E
N
K
T
Y
F
G
T
T
D
T
D
Y
-
Q
G
D
F
T
D
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
G
L
R
P
L
L
-------
I
G
---------------------
S
-
S
-------
L
--
E
R
E
P
D
-
G
---
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
---
L
K
-------
E
E
YG
I
E
T
K
E
I
--
D
S
K
K
-
Y
Q
I
S
---
G
G
N
F
D
P
--------------
T
K
L
E
E
T
V
T
E
L
A
K
E
G
V
-
A
A
---------
G
L
E
E
E
D
A
T
------
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
-------
A
--
K
E
M
-
A
P
Y
---
P
G
L
S
L
A
E
S
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
----
3
PsiBlast_PDB
81.85
28%
-84
- C1 -
2RGO
1
?
A:
[2-553]
----
F
S
N
K
T
R
Q
D
S
I
Q
K
M
-
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
-
G
I
-
K
-
T
G
L
I
E
M
-
Q
-
D
F
A
E
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
-
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
-
A
---
P
-
H
-
I
P
K
P
---------
D
P
M
L
L
P
I
Y
E
D
--
E
---
G
A
T
T
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
L
A
--
N
---
V
T
--
G
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
G
-----
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
G
D
Q
I
V
G
V
K
A
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
------
L
-
N
FT
R
P
V
S
----
P
K
M
----
R
P
T
---
K
G
I
H
L
V
V
D
A
K
K
L
P
V
P
Q
P
T
Y
F
D
T
G
K
-
Q
-
D
G
R
M
V
F
A
I
P
R
-
E
N
K
T
Y
F
G
T
T
D
T
D
Y
Q
-
G
D
F
T
D
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
G
L
R
P
L
L
IGNSGSD
Y
N
------
G
G
----------------TISRG
S
S
L
--
E
R
E
-
P
D
G
---
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
---
L
K
E
E
YG
I
E
T
K
-------
E
---
I
D
S
K
K
Y
Q
I
S
---
G
G
N
F
D
P
TK
L
E
E
T
V
T
E
L
A
K
E
G
V
---------------
A
A
---------
G
L
E
E
E
D
A
T
------
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
-------
A
--
K
E
-
A
P
-
Y
---
P
G
L
S
L
A
E
S
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
--------------------------------------------------
90
HHSearch
79.86
30%
-87
- C1 -
3DA1
1
?
A:
[4-542]
------
A
K
K
R
D
K
C
I
G
E
M
-
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
-
G
I
-
Q
-
T
G
L
V
E
M
-
N
-
D
F
A
S
G
T
S
S
R
S
T
K
L
V
H
G
-----------------
V
G
K
E
R
A
I
V
Y
E
N
-
A
---
P
-
H
-
V
T
T
P
E
W
M
L
L
P
I
F
K------------------------------------------------
R
Y
M
--
L
N
E
K
Q
T
L
E
K
--
E
P
L
L
R
K
E
N
-----
L
K
G
G
G
I
Y
-
V
E
-
Y
R
T
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
Q
G
K
V
V
G
V
V
A
K
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
------
K
D
R
SK--
H
G
----
K
Y
L
----
K
L
S
---
K
G
V
H
L
V
V
D
Q
S
R
F
P
L
R
Q
A
V
Y
F
-
D
T
E
-
S
-
D
G
R
M
I
F
A
I
P
R
-
E
G
K
T
Y
I
G
T
T
D
T
F
Y
-
D
K
D
I
A
S
P
R
M
T
V
E
D
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
S
S
W
A
G
L
R
P
L
I
-------
H
E
---------------------
D
-
E
-------
I
--
F
F
S
D
S
-
G
---
L
I
S
I
A
G
---
G
---
K
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
---
L
N
-------
V
-------
N
EPC
T
T
A
A
-
I
R
L
S
---
G
G
L
A
E
G
--------------
A
QG
F
P
R
F
L
D
E
A
S
R
K
G
A
K
L
---------
G
F
D
A
D
E
V
R
------
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
-------
A
--
Y
E
G
-
K
E
E
A
E
H
Y
G
L
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
S
W
T
E
E
E
K
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
V
----
1
PsiBlast_PDB
75.82
32%
-87
- C1 -
3DA1
1
?
A:
[17-495]
--------------------
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
-
G
I
-
Q
-
T
G
L
V
E
M
-
N
-
D
F
A
S
G
T
S
S
R
S
T
K
L
V
H
G
-----------------
V
G
K
E
R
A
I
V
Y
E
N
-
A
---
P
-
H
-
V
T
T
P
---------
E
W
M
L
L
P
I
F
K
-----------------------------------------
R
--
Y
M
L
N
E
K
Q
T
L
E
K
E
P
L
L
R
K
E
N
-----
L
K
G
G
G
I
Y
-
V
E
-
Y
R
T
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
Q
G
K
V
V
G
V
V
A
K
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
------
K
-
D
----
R
S
----
K
H
G
----
K
Y
L
K
L
S
K
G
V
H
L
V
V
D
Q
S
R
F
P
L
R
Q
A
V
Y
F
-
D
T
E
-
S
-
D
G
R
M
I
F
A
I
P
R
-
E
G
K
T
Y
I
G
T
T
D
T
F
Y
D
K
D
I
A
-
S
P
R
M
T
V
E
D
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
S
S
W
A
G
L
R
P
L
I
-------
H
---------
E
-----------
D
E
-
I
-------
F
--
F
S
D
-
S
-
G
---
L
I
S
I
A
G
---
G
---
K
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
---
L
N
-------
V
-------
N
---
E
P
C
T
T
A
A
I
R
LSG
G
L
A
E
G
A
QG
F
P
R
---------
F
---------------
L
D
E
A
S
R
K
G
A
K
L
G
F
D
A
D
E
V
R
------
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
-------
A
Y
E
G
K
E
E
A
E
H
---
Y
G
L
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
---------------------------------------------------
2
PsiBlast_PDB
75.07
33%
-96
* C2 *
2RGH
2
?
A:
[16-412]
----
F
S
N
K
T
R
Q
D
S
I
Q
K
M
-
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
-
G
I
-
K
-
T
G
L
I
E
M
-
Q
-
D
F
A
E
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
-
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
-
A
---
P
-
H
-
I
P
K
P
---------
D
P
M
L
L
P
I
Y
E
D
--
E
---
G
A
T
T
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
L
A
--
N
---
V
T
--
G
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
L
K
K
E
G
-----
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
G
D
Q
I
V
G
V
K
A
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
------
L
-
N
----
F
T
----
R
P
V
SPK
M
R
P
T
---
K
G
I
H
L
V
V
D
A
K
K
L
P
V
P
Q
P
T
Y
F
D
T
G
K
-
Q
-
D
G
R
M
V
F
A
I
P
R
-
E
N
K
T
Y
F
G
T
T
D
T
D
Y
Q
-
G
D
F
T
D
P
K
V
T
Q
E
D
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
G
L
R
P
L
L
-------
I
G
---------------------
S
-
S
-------
L
--
E
R
E
-
P
D
G
---
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
---
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.10
31%
-74
- C1 -
2R4J
22
GLPD_ECOLI
A:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
6
PsiBlast_PDB
72.61
31%
-72
- C1 -
2R46
23
GLPD_ECOLI
A:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
22
PsiBlast_CBE
72.54
31%
-73
- C1 -
2R46
14
GLPD_ECOLI
B:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
DI
H
D
E
-
N
-
G
KAP
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
YPFLTE
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
LLGNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
4
PsiBlast_PDB
72.43
31%
-71
- C1 -
2QCU
24
GLPD_ECOLI
A:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
23
PsiBlast_CBE
72.35
31%
-73
- C1 -
2R45
15
GLPD_ECOLI
B:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
DI
H
D
E
-
N
-
G
KAP
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
YPFLTE
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
LLGNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
21
PsiBlast_CBE
72.25
31%
-73
- C1 -
2R4E
18
GLPD_ECOLI
B:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
DI
H
D
E
-
N
-
G
KAP
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
YPFLTE
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
LLGNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
5
PsiBlast_PDB
72.15
31%
-74
- C1 -
2R45
27
GLPD_ECOLI
A:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
7
PsiBlast_PDB
71.72
31%
-74
- C1 -
2R4E
20
GLPD_ECOLI
A:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
24
PsiBlast_CBE
71.56
31%
-72
- C1 -
2QCU
12
GLPD_ECOLI
B:
[29-477]
--------------------------------------------------
V
L
M
L
E
A
-
Q
-
D
L
A
C
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
-
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
-
A
---
P
-
H
-
I
A
F
P
---------
M
R
F
R
L
P
H
R
P
H
L
R
P
---
A
W
M
I
R
I
G
L
-----
F
-
M
Y
D
H
L
G
--
K
---
R
T
--
S
--
L
--
P
G
S
T
G
L
R
F
G
--
A
N
S
V
L
K
P
E
-----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
N
G
L
W
I
-
V
E
A
E
D
I
D
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
------
D
-
G
MHLP
S
P
----
Y
G
I
----
R
L
I
---
K
G
S
H
I
V
V
P
--
R
V
H
T
Q
K
Q
A
Y
I
-
L
Q
N
-
E
-
D
K
R
I
V
F
V
I
P
W
M
D
E
F
S
I
I
G
T
T
D
V
E
Y
K
-
G
D
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
T
H
F
-
K
K
Q
L
S
R
D
D
I
V
W
T
Y
S
G
V
R
P
L
C
-------
D
--------
D
E
S
D
S
P
--
Q
A
I
T
R
D
Y
-
T
-------
L
D
I
H
D
E
-
N
-
G
KA
P
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
YQG
I
G
-------
P
-------
A
---
W
T
K
E
S
V
L
P
G
---
G
A
I
E
G
D
--------------
R
---------------
D
D
---------
Y
A
A
R
L
R
R
R
Y
PFLT
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
GNAGT
V
--
S
D
L
G
E
D
F
-----
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
L
---------------------------------------------
114
Fugue
57.25
23%
-66
- C1 -
3DME
4
?
A:
[3-368]
--------------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
-
G
H
-
E
-
V
L
V
A
E
A
A
E
-
G
I
G
T
G
T
S
S
R
N
S
E
V
I
H
A
G
I
Y
Y
P
A
-
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
-
R
---
G
-
V
-
P
H
Q
R
---------
L
G
K
L
I
V
A
T
--------
S
D
A
E
A
S
Q
L
-----
D
S
I
A
R
R
A
G
A
N
G
---
V
D
--
D
L
Q
H
--
I
D
G
A
A
A
R
R
L
--
E
P
A
L
H
C
T
A
-----
A
L
V
S
P
S
T
----
G
I
V
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
A
Q
L
V
F
H
T
P
L
I
A
G
R
V
R
P
E
G
G
F
E
L
D
F
G
G
A
E
P
---
M
T
L
S
C
R
V
L
I
N
A
A
G
L
H
A
P
G
L
A
R
R
IEGIP
R
-
D
----
S
I
----
P
P
E
----
Y
L
C
---
K
G
S
Y
F
T
L
A
G
R
A
P
F
S
R
L
I
Y
P
V
-
P
Q
H
-
A
-
G
L
G
V
H
L
T
L
D
L
-
G
G
Q
A
K
F
G
P
---
D
T
E
W
I
A
T
E
D
Y
T
L
D
P
R
R
A
D
V
F
Y
A
A
V
R
S
Y
W
P
A
--
L
P
D
G
A
L
A
P
G
Y
T
G
I
R
P
K
I
-------
S
G
------
P
H
E
P
A
A
D
FA
I
A
G
P
A
S
H
-------------
G
V
-
A
-
G
---
L
V
N
L
Y
G
----------------------------------------------------------------
I
E
S
P
------------------------------------------------------------------------------------------------
G
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
------------------------------------------------------------
93
HHSearch
54.96
15%
-67
- C1 -
1Y56
4
?
B:
[3-355]
-------------------
P
E
K
S
E
I
V
V
I
G
G
G
I
V
G
V
T
I
A
H
E
L
A
K
R
-
G
E
-
E
-
V
T
V
I
E
K
-
R
-
F
I
G
S
G
S
T
F
R
C
G
T
G
I
R
Q
Q
F
--
N
D
-
E
-
A
N
V
R
V
M
K
R
S
V
E
L
W
K
K
Y
S
E
E
-
Y
---
G
-
F
-
S
F
K
Q
---------
T
G
Y
L
F
L
L
Y
D
D
E
E
V
---
K
T
F
--
K
--------
R
N
I
E
I
Q
N
--
K
---
F
G
V-
P
T
K
L
--
I
T
P
E
E
A
K
E
I
--
V
P
L
L
D
I
S
E
-----
V
I
A
A
S
W
N
-
P
T
D
G
K
A
D
P
F
E
A
T
T
A
F
A
V
K
A
K
E
Y
G
A
K
L
L
E
Y
T
E
V
K
G
F
L
I
E
N
N
E
I
K
G
V
K
T
N
K
------
G
I
I
K
T
G
I
V
V
N
A
T
N
A
W
A
N
L
I
N
A
------
M
A
G
IK--
T
K
----
I
P
I
----
E
P
Y
---
K
H
Q
A
V
I
T
Q
P
I
K
R
G
T
I
N
P
M
V
I
-
S
-
F
---
K
Y
G
H
A
Y
L
T
Q
T
F
H
G
G
I
I
G
G
I
G
Y
E
I
G
---
P
T
Y
D
L
T
P
T
Y
E
F
L
R
E
V
S
Y
Y
F
T
K
I
I
P
A
L
K
--
N
L
L
I
L
R
T
W
A
G
Y
Y
A
K
T
-------
P
D
------
S
N
P
A
I
G
R
--
I
E
------
E
------------
L
-
N
-
D
---
Y
Y
I
A
A
G
FSG
H
---
G
F
M
M
A
P
A
V
G
E
M
V
A
E
L
I
T
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
53.16
22%
-59
- C1 -
3DME
4
?
A:
[3-368]
--------------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
-
G
H
-
E
-
V
L
V
A
E
A
-
A
E
G
I
G
T
G
T
S
S
R
N
S
E
V
I
H
A
G
I
Y
Y
P
A
-
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
-
R
---
G
-
V
-
P
H
Q
R
---------
L
G
K
L
I
V
A
T
S
D
A
E
A
---
S
Q
L
--
D
--------
S
I
A
R
R
A
G
--
A
---
N
G
VD
D
L
Q
H
--
I
D
G
A
A
A
R
R
L
--
E
P
A
L
H
--------
C
T
A
A
L
V
S
-
P
S
T
G
I
V
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
A
Q
L
V
F
H
T
P
L
I
A
G
R
V
R
P
E
G
G
F
E
L
D
F
G
G
A
---
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
L
H
A
P
G
L
A
R
------
R
I
E
G---
I
P
RDSI
P
P
E
----
Y
L
C
---
K
G
S
Y
F
T
L
A
G
R
A
P
F
--
S
R
L
I
Y
-
P
V
P
-
Q
H
A
G
L
G
V
H
L
T
L
D
L
G
G
Q
A
K
F
G
P
D
T
E
W
I
---
A
T
E
D
Y
T
L
D
P
R
R
A
D
V
F
Y
A
A
V
R
S
Y
W
P
A
L
P
--
D
G
A
L
A
P
G
Y
T
G
I
R
P
K
I
-------
S
G
PHEPAA
D
F
A
I
-------
A
G
P
A
S
H
G
------------
V
-
A
-
G
---
L
V
N
L
Y
G
---
I
ESP
G
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
51.85
17%
-66
* C1 *
2GAG
4
?
B:
[12-376]
------------
L
W
A
N
P
E
P
K
K
S
Y
D
A
I
I
V
G
G
G
G
H
G
L
A
T
A
Y
F
L
A
K
N
H
G
I
T
N
-
V
A
V
L
E
K
-
G
-
W
L
A
G
G
N
M
A
R
N
T
T
I
I
R
S
N
Y
L
W
D
E
----
S
A
G
I
Y
E
K
S
L
K
L
W
E
Q
L
P
E
D
-
L
EY-
D
-
F
-
L
F
S
Q
---------
R
G
V
L
N
L
A
H
T
L
G
D
V
---
R
E
S
V
----------
R
R
V
E
A
N
K
--
L
---
N
G
V
-
D
A
E
W
--
L
D
P
S
Q
V
K
E
A
--
C
P
I
I
N
T
S
D
DIRYP
V
M
G
A
T
W
Q
-
P
R
A
G
I
A
K
H
D
H
V
A
W
A
F
A
R
K
A
N
E
M
G
V
D
I
I
Q
N
C
E
V
T
G
F
I
K
D
G
E
K
V
T
G
V
K
T
T
R
------
G
T
I
H
A
G
K
V
A
L
A
G
A
G
H
S
S
V
L
A
E
------
M
A
G
----
F
E
----
L
P
I
----
Q
S
H
---
P
L
Q
A
L
V
S
E
L
F
E
-
P
V
H
P
T
V
V
M
-
S
-----
N
H
I
H
V
Y
V
S
Q
A
H
K
G
E
L
V
M
G
A
G
I
D
S
Y
-
N
G
-
Y
-
G
Q
R
G
A
F
H
V
I
Q
E
Q
M
A
A
A
V
E
L
F
P
I
F
A
--
R
A
H
V
L
R
T
W
G
G
I
V
D
T
T
-------
M
D
------
A
S
P
I
I
S
K
--
T
-----
P
--------------
I
-
Q
-
N
---
L
Y
V
N
C
G
WGT
G
---
G
F
K
G
T
P
G
A
G
F
T
L
A
H
T
I
A
N
D
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
51.15
17%
-69
- C1 -
1RYI
2
GLOX_BACSU
A:
[15-363]
-------------------
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
-
N
K
-
N
-
T
A
L
F
E
S
-
G
-
T
M
G
G
R
T
T
S
A
A
A
G
M
L
G
A
H
A
E
C
E
E
R
D
-
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
S
G
V
D
I
R
Q
H
N
---------
G
G
M
F
K
L
A
F
S
E
E
D
V
---
L
Q
L
--------------
R
Q
M
D
--
D
---
L
D
--
S
V
S
W
--
Y
S
K
E
E
V
L
E
K
--
E
P
Y
A
S
G
-
D
-----
I
F
G
A
S
F
I
-
Q
D
D
V
H
V
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
G
E
-
A
L
F
I
K
T
P
S
------
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
------
Q
L
G
----
L
N
----
N
A
F
----
L
P
V
---
K
G
E
C
L
S
V
W
N
D
D
I
P
L
-
T
K
T
L
Y
--------
H
D
H
C
Y
I
V
P
R
K
S
G
R
L
V
V
G
A
T
M
K
P
G
-
D
--
W
-
S
E
T
P
D
L
G
G
L
E
S
V
M
K
K
A
K
T
M
L
P
A
I
Q
--
N
M
K
V
D
R
F
W
A
G
L
R
P
G
T
-------
K
D
------
G
K
P
Y
I
G
R
--
H
P
E
------------------
D
-
S
-
R
---
I
L
F
A
A
G
HFR
N
---
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Fugue
50.78
16%
-60
- C1 -
1X31
4
?
B:
[1-402]
-
A
D
L
L
P
E
H
P
E
F
L
W
N
N
P
E
-
P
K
K
S
Y
D
V
V
I
V
G
G
G
G
H
G
L
A
T
A
Y
Y
L
A
K
N
H
G
I
-
T
N
V
A
V
L
E
K
-
G
-
W
L
A
G
G
N
M
A
R
N
T
T
I
I
R
S
--
N
Y
L
W
-
D
-
E
S
A
G
I
Y
E
K
S
L
K
L
W
E
E
L
P
E
E
-
L
EYD
F
-
L
-
F
S
Q
R
---------
G
V
L
N
L
A
H
T
L
G
D
V
R
---
E
S
I
R
R
V
E
A
-----
N
K
F
N
G
V
D
A
--
E
---
W
L
--
T
P
E
Q
--
V
K
E
V
C
P
I
I
N
--
T
G
D
N
I
R
Y
P
-----
V
M
G
A
T
Y
Q
P
R
A
-
G
I
A
K
H
D
H
V
A
W
A
F
A
R
K
A
N
E
M
G
V
D
I
I
Q
N
C
E
V
T
G
F
L
K
D
G
E
K
V
T
G
V
K
T
T
R
G
------
T
I
L
A
G
K
V
A
L
A
G
A
G
H
S
S
V
L
A
E
------
L
-
A
----
G
F
----
E
L
------
P
I
---
Q
S
H
P
L
Q
A
L
V
S
E
L
F
E
P
V
H
P
T
V
-
V
M
S
-
N
-
H
I
H
V
Y
V
S
Q
A
H
-
K
G
E
L
V
M
G
A
G
I
D
S
Y
N
G
---
Y
G
Q
R
G
A
F
H
V
I
E
E
Q
M
A
A
A
V
E
L
F
--
P
I
F
A
R
A
H
V
L
R
T
W
G
G
I
V
D
T
T
-------
M
D
------
A
------------------------------------------------------------------
S
P
I
---
I
S
-------
K
-------
T
---
P
I
Q
N
L
Y
V
N
C
---
G
-----------------------------------------------------------------------------------
W
--
G
T
G
G
F
K
G
---
T
P
G
A
G
Y
T
L
A
H
T
I
A
H
D
E
P
H
K
--
L
N
A
P
F
A
L
E
R
F
E
T
G
H
L
I
D
E
H
G
A
A
A
V
-------------------------------------