@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3195: (2016-02-14 )
MTIRLAINGFGRIGRNVLRALYTGHYREQLQVVAINDLGDAAVNAHLFQYDSVHGHFPGEVEHDAESLRVMGDRIAVSAIRNPAELPWKSLGVDIVLECTGLFTSRDKAAAHLQAGAGKVLISAPGKDVEATVVYGVNHEVLRASHRIVSNASCTTNCLAPVAQVLHRELGIEHGLMTTIHAYTNDQNLSDVYHPDLYRARSATQSMIPTKTGAAEAVGLVLPELAGKLTGLAVRVPVINVSLVDLTVQVARDTSVDEVNRLLREASEGSPVLGYNTQPLVSVDFNHDPRSSIFDANHTKVSGRLVKAMAWYDNEWGFSNRMLDSALALAAARD
Atome Classification :
(38 SA)
.........10........20..--.....---.30......-.-.40........50.......-.60..-.-.....70......-..80........90........100.......110.......120....-..-.130.......140-.-.-.....150.......160.......170.......180.......190..--.....200........210.......220.......230.......240.......250-.-......260.......---------270.--........280-.......290.......300..-......310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
R
L
A
IN
G
F
G
R
I
G
R
N
V
L
R
A
L
Y
T--G
H
Y
R
E
---
Q
L
Q
V
V
A
IND-L-GD
A
A
V
N
A
H
L
F
Q
YDSVHGHFP-GEVEH-
D
-
A
E
S
L
R
V
M
G
D
R
I
A
V
-
S
AIR
N
P
AEL
P
W
K
SL
G
V
D
I
V
L
E
CTGLFTSR
D
K
A
A
A
H
LQAGA
G
K
V
L
I
SAPG-KD-
V
E
A
T
V
V
YGV
N
H
E
V
L
-
R
-
A
-
S
H
R
IVSNASCT
T
N
C
L
A
P
V
A
Q
V
L
H
R
E
LGIEH
G
L
M
T
T
I
H
A
YTNDQN
L
S
D
VYH--
P
D
L
Y
R
A
-
R
S
A
T
Q
SMIPTKTGA
A
E
A
V
G
L
V
L
P
E
L
A
G
KLT
G
L
A
V
R
V
P
V
I
N
V
S
L
V
D
L
T
V
Q
VAR-D-T
S
V
D
E
V
N
R
L
L
R
EASEG---------S--
P
--
V
LGYNTQ
P
L
V
S
-
V
DFNHDPRSSIFDANHTKV-S
G
-
R
L
V
K
A
M
A
W
YDNEWGFSN
R
M
L
D
S
A
L
A
L
AAARD
23
PsiBlast_CBE
95.47
68%
-104
- C4 -
3GNQ
2
?
F:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
1
PsiBlast_PDB
94.61
68%
-104
- C4 -
3GNQ
1
?
A:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
22
PsiBlast_CBE
94.52
68%
-102
- C4 -
3GNQ
2
?
G:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
25
PsiBlast_CBE
94.19
68%
-103
- C4 -
3GNQ
2
?
D:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
26
PsiBlast_CBE
93.50
68%
-102
- C4 -
3GNQ
2
?
C:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
21
PsiBlast_CBE
93.38
68%
-102
- C4 -
3GNQ
2
?
H:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
27
PsiBlast_CBE
93.30
68%
-105
- C4 -
3GNQ
1
?
B:
[10-343]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
--
2
PsiBlast_PDB
93.12
58%
-106
- C4 -
3L0D
1
?
A:
[22-353]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
--
S
G
-
R
Q
---
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
-
G
T
V
Q
V
-
V
-
G
D
A
I
D
I
---
L
I
K
V
-
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
-
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
-
S
-
K
-
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
G
---------
S
LK
G
--
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
-
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
----
24
PsiBlast_CBE
92.69
68%
-104
- C4 -
3GNQ
2
?
E:
[10-344]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
--
N
G
K
K
H
---
D
L
E
I
V
A
I
N
D
-
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
-
G
E
V
S
V
-
D
-
G
D
Y
L
V
V
N
G
D
R
I
R
V
-
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
K
D
-
V
D
A
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
-
E
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
-
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
G
---------
A
LK
G
--
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
30
PsiBlast_CBE
92.14
61%
-105
- C4 -
3DOC
2
?
C:
[1-332]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
--
S
G
-
R
T
---
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
-
K
E
V
E
V
-
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
-
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
-
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
-
T
-
K
-
D
H
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
G
RL-------
K
--
G
--
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
D
G
-
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
----
29
PsiBlast_CBE
91.27
61%
-103
- C4 -
3DOC
2
?
D:
[2-332]
-
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
--
S
G
-
R
T
---
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
-
K
E
V
E
V
-
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
-
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
-
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
-
T
-
K
-
D
H
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
G
RL-------
K
--
G
--
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
D
G
-
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
----
3
PsiBlast_PDB
90.25
61%
-104
- C4 -
3DOC
2
?
A:
[1-332]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
--
S
G
-
R
T
---
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
-
K
E
V
E
V
-
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
-
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
-
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
-
T
-
K
-
D
H
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
G
RL-------
K
--
G
--
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
D
G
-
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
----
121
HHSearch
90.23
61%
-103
- C4 -
3DOC
2
?
A:
[1-334]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
S
G
R
---
T
---
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
-
K
E
V
E
V
-
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
-
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
-
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
-
T
-
K
-
D
H
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
G
---------
R
LK
G
--
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
-
M
D
G
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
L
--
31
PsiBlast_CBE
90.02
61%
-102
- C4 -
3DOC
2
?
B:
[1-332]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
--
S
G
-
R
T
---
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
-
K
E
V
E
V
-
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
-
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
-
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
-
T
-
K
-
D
H
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
G
RL-------
K
--
G
--
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
D
G
-
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
----
28
PsiBlast_CBE
89.70
58%
-104
- C4 -
3L0D
1
?
B:
[22-353]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
--
S
G
-
R
Q
---
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
-
G
T
V
Q
V
-
V
-
G
D
A
I
D
I
---
L
I
K
V
-
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
-
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
-
S
-
K
-
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
G
---------
S
LK
G
--
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
-
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
----
4
PsiBlast_PDB
88.59
53%
-112
- C4 -
2X5J
1
E4PD_ECOLI
O:
[2-334]
-
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
---
E
I
T
V
V
A
I
N
E
-
L
-
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
-
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
-
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
D
-
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
-
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
-------------
D
L
R
R
T
-
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
-
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
G
---------
A
FH
G
--
I
V
D
Y
T
E
L
P
L
V
S
-
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
-
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
----
32
PsiBlast_CBE
88.29
53%
-113
- C4 -
2X5J
1
E4PD_ECOLI
R:
[2-334]
-
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
---
E
I
T
V
V
A
I
N
E
-
L
-
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
-
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
-
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
D
-
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
-
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
-------
A
Y
H
--
P
D
L
R
R
T
-
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
-
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
G
---------
A
FH
G
--
I
V
D
Y
T
E
L
P
L
V
S
-
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
-
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
----
122
HHSearch
88.17
54%
-109
- C4 -
2X5J
1
E4PD_ECOLI
O:
[2-336]
-
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
---
G
RRA
E
I
T
V
V
A
I
N
E
-
L
-
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
-
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
-
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
-
S
N
D
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
-
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
-------------
D
L
R
R
T
-
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
-
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
G
---------
A
FH
G
--
I
V
D
Y
T
E
L
P
L
V
S
-
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
-
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
--
43
PsiBlast_CBE
88.13
53%
-113
- C4 -
2XF8
1
E4PD_ECOLI
H:
[1-333]
-
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
---
E
I
T
V
V
A
I
N
E
-
L
-
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
-
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
-
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
D
-
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
-
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
---------------------
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
-
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
G
---------
A
F
H
G
--
I
V
D
Y
T
E
L
P
L
V
S
-
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
-
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
----
45
PsiBlast_CBE
87.93
53%
-112
- C4 -
2XF8
1
E4PD_ECOLI
F:
[1-333]
-
T
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
--
S
G
R
R
A
---
E
I
T
V
V
A
I
N
E
-
L
-
A
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
A
-
W
E
V
R
Q
-
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
-
L
H
E
R
S
L
Q
S
L
P
W
R
E
L
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
D
-
L
D
A
T
V
V
Y
G
V
N
Q
D
Q
L
-
R
-
A
-
E
H
R
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
--------------
D
L
R
R
T
-
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
-
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
G
---------
A
F
H
G
--
I
V
D
Y
T
E
L
P
L
V
S
-
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
-
S
G
A
H
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
----
127
HHSearch
87.76
53%
-98
- C4 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
---
E
---
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
-
G
S
V
E
A
-
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
-
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
-
N
-
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKV--
Y
LK
E
--
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
120
HHSearch
86.30
50%
-95
- C4 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
S
---
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
-
A
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
-
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
-
T
-
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
---------
E
LK
G
--
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
89
PsiBlast_CBE
86.30
51%
-100
- C4 -
4BOY
1
?
A:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
19
PsiBlast_PDB
86.10
51%
-97
- C4 -
2EP7
1
G3P_AQUAE
A:
[3-338]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
-----
R
E
---
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
-
G
S
V
E
A
-
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
-
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
-
N
P
K
-
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYL
K
--
E
--
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
----
20
PsiBlast_PDB
85.98
51%
-98
- C4 -
3ZCX
1
?
A:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
88
PsiBlast_CBE
85.91
51%
-98
- C4 -
4BOY
1
?
B:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
92
PsiBlast_CBE
85.84
51%
-98
- C4 -
3ZCX
1
?
B:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
87
PsiBlast_CBE
85.84
51%
-97
- C4 -
2EP7
1
G3P_AQUAE
B:
[2-338]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
-----
R
E
---
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
-
G
S
V
E
A
-
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
-
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
-
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
-
N
P
K
-
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYL
K
--
E
--
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
----
90
PsiBlast_CBE
85.37
51%
-99
- C4 -
3ZDF
2
?
B:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
108
Fugue
85.31
53%
-99
- C4 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R-
K
N
P
D
-----
I
E
V
V
A
I
N
D
L--
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
-
G
K
V
E
Y
T--
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
-
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
-
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
--
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
-
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
---------
R
--
L
KG
I
I
G
Y
N
D
E
P
I
V
S
S-
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
-
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
91
PsiBlast_CBE
85.12
51%
-100
- C4 -
3ZDF
2
?
A:
[19-351]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
S
---
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
-
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
-
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
-
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
-
D
-
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
T
---------
T
MK
G
--
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
---
125
HHSearch
84.68
47%
-102
- C4 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
R
---
N
---
D
I
T
V
V
A
I
N
D
-
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
-
G
T
V
E
V
-
S
-
G
-
D
L
C
I
N
G
K
V
V
K
V
-
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
-
K
D
-
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
-
D
-
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
KG-
D
W
R
A
G
-
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
G
---------
P
MK
G
--
I
M
G
Y
T
S
D
D
V
V
S
-
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
-
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
-
123
HHSearch
84.65
54%
-98
- C4 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RK
N
---
P
---
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
-
G
K
V
E
Y
-
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
-
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
-
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
-
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
---------
R
LK
G
--
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
-
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
128
HHSearch
84.53
48%
-102
* C4 *
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
--
R
---
P
---
N
V
E
V
V
A
L
N
D
-
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
-
G
E
V
S
H
-
D
-
D
K
H
I
I
V
D
G
K
K
I
A
T
-
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
-
S
T
--
A
P
M
F
V
M
G
V
N
E
E
K
Y
-
T
-
S
-
D
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H-
K
D
W
R
G
G
-
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
-
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
G
---------
K
LK
G
--
V
L
G
Y
T
E
D
A
V
V
S
-
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
-
L
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
---
7
PsiBlast_PDB
81.24
53%
-93
- C4 -
1HDG
3
G3P_THEMA
O:
[2-325]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
---
R
K
N
P
---
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
-
G
K
V
E
Y
-
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
-
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
-
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
-
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
RL-------
K
--
G
--
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
-
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
---------
53
PsiBlast_CBE
81.11
53%
-93
- C4 -
1HDG
3
G3P_THEMA
Q:
[2-325]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
---
R
K
N
P
---
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
-
G
K
V
E
Y
-
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
-
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
-
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
-
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
RL-------
K
--
G
--
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
-
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
---------
93
PsiBlast_CBE
79.56
51%
-98
- C4 -
1VC2
1
?
A:
[1-321]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
------
E
R
---
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
P
-
G
A
V
G
Y
-
D
-
E
E
N
L
Y
V
D
G
K
A
I
R
A
-
T
A
I
K
D
P
R
E
I
P
W
K
Q
A
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
-
K
N
-
E
D
I
T
V
V
L
G
V
N
H
E
Q
Y
-
D
P
A
-
K
H
H
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
K
R
-
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
G
P
L-------
K
--
G
--
I
L
A
Y
T
E
D
E
I
V
L
-
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
-
I
G
-
N
L
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
----------
132
HHSearch
78.83
44%
-97
- C4 -
3H9E
10
G3PT_HUMAN
O:
[6-339]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
K
-------
G
V
K
V
V
A
V
N
D
-
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
-
G
S
V
E
F
-
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
-
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
-
P
D
--
A
P
M
F
V
M
G
V
N
E
N
D
Y
-
N
-
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R-
K
A
W
R
D
G
-
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
-
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
G
---------
P
MA
G
--
I
L
A
Y
T
E
D
E
V
V
S
-
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
-
L
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
-