@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4715: (2016-02-29 )
MAESRPARRFARIDRLPPYVFNITAELKMAARRRGEDIIDLSMGNPDGPTPPHIVEKLCTVAQREDTHGYSTSRGIPRLRRAISHWYRDRYDVQIDPESEAIVTIGSKEGLAHLMLATLDHGDTILVPNPSYPIHIYGAVIAGAQVRSVPLVPGIDFFNELERAIRESIPKPRMMILGFPSNPTAQCVELDFFERVVALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDIAVEFFTLSKSYNMAGWRIGFMVGNPELVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIARQYQQRRDVLVKGLREAGWMVENPKASMYVWAKIPEPYAHLGSLEFAKKLLQDAKVSVSPGIGFGDYGDDHVRFALIENRDRLRQAVRGIKAMFRADGLLSPQRKVDSLAE
Atome Classification :
(20 SA)
.........10......-..20........30..---.......40........50........60...----.--....---70-........80........90-.-.......100.......110.......120-..----......130.......140...------------..--..150..---------.--------....160.......-170........180.......190.......200.......210.......220...-....---230---........240.......250.......260..--------.....270.......280.......290-----..-------.--......300.......310.......320.......330.......--------340-------.........350.......360..------..------.-----..370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAES
R
P
A
R
R
F
A
R
I
DRLP-
P
Y
V
F
N
I
T
A
E
L
K
M
A
-
A
R
---RRGE
D
I
I
D
L
SMGNPDGPT
P
P
H
I
V
E
K
L
C
T
V
A
QR----E--DTHG---YS-TSR
G
I
P
R
L
R
R
A
I
S
H
W
YRD
R
Y
-
D
-
V
Q
IDPES
E
A
I
V
T
IGSKE
G
L
A
H
L
M
L
ATLDH--G
D
----
T
I
L
VPNPS
Y
P
I
H
I
Y
G
A
V
IAG
A
Q
------------
V
R--SVPLVP
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
SI-PK-P
R
M
M
I
L
GFPSNPTAQ
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
QY
D
V
M
V
V
HDL
A
Y
A
D
I
VYDGWKAP
S
-
I
M
QV---PG----AK
D
I
A
V
E
F
F
T
LSKSYNMA
G
W
R
I
G
F
M
VG
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
HDYGTF
T
P
L
Q
V
A
A
I
AALE-------G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
EAG
W
M
VENPKA
S
M
Y
V
W
A
KIP
E
P
Y
A
--------H---------LG
S
L
E
F
A
K
K
L
L
Q
DAKVSVSPGIGF------GD------Y-----GDD
H
V
R
F
A
L
IE
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
ADGLL
S
P
Q
R
K
V
D
S
LAE
21
PsiBlast_CBE
97.32
100%
-124
- C1 -
2X5D
6
?
D:
[21-400]
--------------------
V
F
N
I
T
A
E
L
K
M
A
-
A
R
---
R
R
G
E
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
R
----
E
--
D
T
H
G
---
Y
S
-
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
-
D
-
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
----
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
G
A
Q
------------
V
R
--
S
V
P
L
V
P
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
S
I
-
P
K
-
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
K
A
P
S
-
I
M
Q
V
---
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
L
Q
V
A
A
I
A
A
L
E
-------
G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
P
E
P
Y
A
--------
H
---------
L
G
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
------
Y
-----
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
------------
41
HHSearch
96.45
100%
-127
- C1 -
2X5D
3
?
A:
[21-400]
--------------------
V
F
N
I
T
A
E
L
K
M
A
-
A
R
---
R
R
G
E
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
-------------------
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
-
D
-
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
----
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
G
A
Q
------------
V
R
--
S
V
P
L
V
P
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
S
I
-
P
K
-
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
K
A
P
S
-
I
M
Q
V
---
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
-
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
L
Q
V
A
A
I
A
A
L
E
-------
G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
P
E
P
Y
A
--------
H
---------
L
G
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
------
Y
-----
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
------------
1
PsiBlast_PDB
96.45
100%
-127
- C1 -
2X5D
3
?
A:
[21-400]
--------------------
V
F
N
I
T
A
E
L
K
M
A
-
A
R
---
R
R
G
E
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
-------------------
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
-
D
-
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
----
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
G
A
Q
------------
V
R
--
S
V
P
L
V
P
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
S
I
-
P
K
-
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
K
A
P
S
-
I
M
Q
V
---
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
-
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
L
Q
V
A
A
I
A
A
L
E
-------
G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
P
E
P
Y
A
--------
H
---------
L
G
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
------
Y
-----
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
------------
23
PsiBlast_CBE
93.33
100%
-127
- C1 -
2X5D
2
?
B:
[21-400]
--------------------
V
F
N
I
T
A
E
L
K
M
A
-
A
R
---
R
R
G
E
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
-------------------
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
-
D
-
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
----
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
G
A
Q
------------
V
R
--
S
V
P
L
V
P
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
S
I
-
P
K
-
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
K
A
P
S
-
I
M
Q
V
---
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
H
D
Y
----
P
L
Q
V
A
A
I
A
A
L
E
-------
G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
P
E
P
Y
A
--------
H
---------
L
G
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
------
Y
-----
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
------------
22
PsiBlast_CBE
92.66
100%
-126
- C1 -
2X5D
4
?
C:
[22-400]
---------------------
F
N
I
T
A
E
L
K
M
A
-
A
R
---
R
R
G
E
D
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
Q
R
------------------
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
-
D
-
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
--
G
D
----
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
G
A
Q
------------
V
R
--
S
V
P
L
V
P
G
---------
I
--------
D
F
F
N
E
L
E
R
A
I
R
E
S
I
-
P
K
-
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
K
A
P
S
-
I
M
Q
V
---
P
G
----
A
K
D
I
A
V
E
F
F
T
L
S
K
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
--------
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
L
Q
V
A
A
I
A
A
L
E
-------
G
D
-------
Q
--
Q
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
P
E
P
Y
A
--------
H
---------
L
G
S
L
E
F
A
K
K
L
L
Q
D
A
K
V
S
V
S
P
G
I
G
F
------
G
D
------
Y
-----
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
A
D
G
L
------------
24
PsiBlast_CBE
62.15
35%
-111
- C1 -
2DOU
4
?
B:
[8-372]
-------------------
S
V
F
L
V
V
D
E
A
K
R
K
-
A
R
---
E
R
G
V
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
----
P
--
T
T
Y
G
---
Y
C
L
K
S
C
T
L
P
F
L
E
E
A
-
A
R
W
Y
E
G
R
Y
-
G
-
V
G
L
D
P
R
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
----
L
L
L
L
P
E
V
A
Y
P
S
Y
F
G
A
A
R
V
A
S
L
R
------------
T
F
--
L
I
P
L
R
E
-------------------
D
G
L
A
D
L
-
K
A
V
P
E
G
V
-
W
R
E
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
-
E
A
P
S
-
P
L
A
L
---
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
S
E
E
A
L
A
--------
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
V
L
R
M
G
V
E
A
L
K
-------
T
P
-------
K
--
E
V
V
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
L
S
L
L
-
P
P
R
A
T
M
Y
L
W
G
R
L
P
E
-----------
G
---------
V
D
D
L
E
F
G
L
R
L
V
E
R
G
-
V
A
L
A
P
G
R
G
F
------
G
P
------
G
-----
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
--------------------
2
PsiBlast_PDB
59.67
35%
-111
- C1 -
2DOU
4
?
A:
[4-372]
---------------
V
P
E
P
S
V
F
L
V
V
D
E
A
K
R
K
-
A
R
---
E
R
G
V
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
----
P
--
T
T
Y
G
---
Y
C
L
K
S
C
T
L
P
F
L
E
E
A
-
A
R
W
Y
E
G
R
Y
-
G
-
V
G
L
D
P
R
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
----
L
L
L
L
P
E
V
A
Y
P
S
Y
F
G
A
A
R
V
A
S
L
R
------------
T
F
--
L
I
P
L
R
E
-------------------
D
G
L
A
D
L
-
K
A
V
P
E
G
V
-
W
R
E
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
-
E
A
P
S
-
P
L
A
L
---
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
S
E
E
A
L
A
--------
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
V
L
R
M
G
V
E
A
L
K
-------
T
P
-------
K
--
E
V
V
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
L
S
L
L
-
P
P
R
A
T
M
Y
L
W
G
R
L
P
E
-----------
G
---------
V
D
D
L
E
F
G
L
R
L
V
E
R
G
-
V
A
L
A
P
G
R
G
F
------
G
P
------
G
-----
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
--------------------
43
HHSearch
58.94
26%
-106
- C1 -
1GD9
2
?
A:
[25-388]
---------------------------------------
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-------
G
L
T
H
---
Y
G
-
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
-
G
-
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
----
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
------------
P
V
--
E
V
P
T
Y
E
E
---------
D
--------
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
-
D
K
-
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
-
I
A
S
L
---
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
--------
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
-------
D
E
R
S
-----
W
--
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
-------------------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
------
A
-----
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
------------
47
HHSearch
58.87
34%
-110
- C1 -
2DOU
4
?
A:
[8-375]
-------------------
S
V
F
L
V
V
D
E
A
K
R
K
-
A
R
---
E
R
G
V
G
L
I
D
L
S
I
G
S
T
D
L
P
P
P
E
A
P
L
K
A
L
A
E
A
L
N
D
----
P
--
T
T
Y
G
---
Y
C
-
L
K
S
C
T
L
P
F
L
E
E
A
A
R
W
Y
E
G
R
Y
-
G
-
V
G
L
D
P
R
R
E
A
L
A
L
I
G
S
Q
E
G
L
A
H
L
L
L
A
L
T
E
P
--
E
D
----
L
L
L
L
P
E
V
A
Y
P
S
Y
F
G
A
A
R
V
A
S
L
R
------------
T
F
--
L
I
P
L
R
E
D
---------
G
----------
L
A
D
L
K
A
V
P
E
G
V
W
-
R
E
-
A
K
V
L
L
L
N
Y
P
N
N
P
T
G
A
V
A
D
W
G
Y
F
E
E
A
L
G
L
A
R
K
H
G
L
W
L
I
H
D
N
P
Y
V
D
Q
V
Y
E
G
E
A
P
S
P
-
L
A
L
----
P
G
----
A
K
E
R
V
V
E
L
F
S
L
S
K
S
Y
N
L
A
G
F
R
L
G
F
A
L
G
S
E
E
A
L
A
--------
R
L
E
R
V
K
G
V
I
D
F
N
Q
Y
A
G
V
L
R
M
G
V
E
A
L
K
-------
T
P
-------
K
--
E
V
V
R
G
Y
A
R
V
Y
R
E
R
A
L
G
M
A
E
A
L
K
G
V
-
L
S
L
L
P
P
R
A
T
M
Y
L
W
G
R
L
P
E
G
V
--------------------
D
D
L
E
F
G
L
R
L
V
-
E
R
G
V
A
L
A
P
G
R
G
F
------
G
P
------
G
-----
G
K
G
F
V
R
I
A
L
V
R
P
L
E
E
L
L
E
A
A
K
R
I
R
E
A
L
-----------------
17
PsiBlast_PDB
57.86
28%
-99
- C1 -
2O0R
3
DAPC_MYCTU
A:
[2-392]
----------
A
T
V
S
R
L
R
-
P
Y
A
T
T
V
F
A
E
M
S
A
L
-
A
T
---
R
I
G
A
--
V
N
L
G
Q
G
F
P
D
E
D
G
P
P
----
K
M
L
Q
A
A
Q
D
----
A
--
I
A
G
G
VNQ
Y
P
-
P
G
P
G
S
A
P
L
R
R
A
I
A
A
Q
R
R
R
H
F
-
G
-
V
D
Y
D
P
E
T
E
V
L
V
T
V
G
A
T
E
A
I
A
A
A
V
L
G
L
V
E
P
--
G
S
----
E
V
L
L
I
E
P
F
Y
D
S
Y
S
P
V
V
A
M
A
G
A
H
------------
R
V
--
T
V
P
L
V
P
D
---------
G
--------
R
G
F
A
L
D
A
D
A
L
R
R
A
V
T
P
R
-
T
R
A
L
I
I
N
S
P
H
N
P
T
G
A
V
L
S
A
T
E
L
A
A
I
A
E
I
A
V
A
A
N
L
V
V
I
T
D
E
V
Y
E
H
L
V
F
D
H
A
R
H
L
P
-
L
A
G
F
---
D
G
----
M
A
E
R
T
I
T
I
S
S
A
A
K
M
F
N
C
T
G
W
K
I
G
W
A
C
G
P
A
E
L
I
A
--------
G
V
R
A
A
K
Q
Y
L
S
Y
V
G
G
A
P
F
Q
P
A
V
A
L
A
L
D
-------
T
E
-------
D
--
A
W
V
A
A
L
R
N
S
L
R
A
R
R
D
R
L
A
A
G
L
T
E
I
G
F
A
V
H
D
S
Y
G
T
Y
F
L
C
A
D
-
P
R
P
L
G
--------
Y
---------
D
D
S
T
E
F
C
A
A
L
P
E
K
V
G
V
A
A
I
P
M
S
A
F
CDP---
A
D
------
V
-----
W
N
H
L
V
R
F
T
F
C
K
R
D
D
T
L
D
E
A
I
R
R
L
S
V
L
------------------
4
PsiBlast_PDB
56.94
29%
-99
- C1 -
1O4S
8
AAT_THEMA
A:
[17-383]
-----------
R
I
S
E
I
P
----
I
S
K
T
M
E
L
D
A
K
-
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
----
G
--
E
V
K
----
Y
T
-
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
-
K
-
K
D
I
S
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
--
G
D
----
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
------------
V
N
--
V
V
E
T
F
M
S
---------
K
--------
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
-
G
K
-
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
-
E
F
T
S
-
I
L
D
V
---
S
E
----
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
--------
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
-------
V
D
-------
N
--
S
Y
---
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
-------------
R
---------
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
------
L
K
------
P
-----
G
--
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
--------------------
44
HHSearch
56.89
29%
-100
- C1 -
1O4S
8
AAT_THEMA
A:
[15-388]
---------
S
R
R
I
S
E
I
P
-
I
S
K
T
M
E
L
D
A
K
A
K
A
-
L
I
---
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
-------
G
E
V
K
---
Y
T
-
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
-
K
-
K
D
I
S
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
--
G
D
----
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
------------
V
N
--
V
V
E
T
F
M
S
---------
K
--------
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
-
G
K
-
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
-
F
T
S
-
I
L
D
V
---
S
E
----
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
--------
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
-------
V
D
------------
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
D
----------------------
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
------
L
K
-------------
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---------------
6
PsiBlast_PDB
55.62
26%
-106
- C1 -
1GDE
4
?
A:
[18-376]
--------------------
L
F
D
I
A
A
G
M
K
------------
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
----
G
--
L
T
H
----
Y
G
-
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
-
G
-
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
----
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
------------
P
V
--
E
V
P
T
Y
E
E
---------
D
--------
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
-
D
K
-
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
-
I
A
S
L
---
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
--------
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
-------
D
E
-------
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
--
T
--------
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
------
A
-----
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
------------------------
9
PsiBlast_PDB
54.80
28%
-94
- C1 -
3JTX
5
?
A:
[6-396]
------------
L
K
Q
L
K
-
P
Y
P
F
A
R
L
H
E
A
M
Q
G
I
S
A
---
P
E
G
M
E
A
V
P
L
H
I
G
E
P
K
H
P
T
P
K
V
I
T
D
A
L
--
T
A
S
L
----
H
--
E
L
E
K
---
Y
P
-
L
T
A
G
L
P
E
L
R
Q
A
C
A
N
W
L
K
R
R
Y
-
D
G
L
T
V
D
A
D
N
E
I
L
P
V
L
G
S
R
E
A
L
F
S
F
V
Q
T
V
L
N
P
G
I
K
P
----
A
I
V
S
P
N
P
F
Y
Q
I
Y
E
G
A
T
L
L
G
G
G
E
------------
I
H
F
A
N
C
P
-
A
P
S
--------------------
F
N
P
D
W
R
S
I
S
E
E
V
-
W
K
R
T
K
L
V
F
V
C
S
P
N
N
P
S
G
S
V
L
D
L
D
G
W
K
E
V
F
D
L
Q
D
K
Y
G
F
I
I
A
S
D
E
C
Y
S
E
I
Y
F
D
G
N
K
P
L
G
-
C
L
Q
A
---
A
A
Q
L
GR
S
R
Q
K
L
L
M
F
T
S
L
S
K
R
S
N
V
P
G
L
R
S
G
F
V
A
G
D
A
E
L
L
K
--------
N
F
L
L
Y
R
T
Y
H
G
S
A
M
S
I
P
V
Q
R
A
S
I
A
A
W
D
--------
D
-------
E
--
Q
H
V
I
D
N
R
R
L
Y
Q
E
K
F
E
R
V
I
P
I
L
Q
Q
V
-
F
D
V
K
L
P
D
A
S
F
Y
I
W
L
K
V
P
D
G
---------------------
D
D
L
A
F
A
R
N
L
W
Q
K
A
A
I
Q
V
L
P
G
R
F
L
ARDTEQ
G
N
------
P
-----
G
E
G
Y
V
R
I
A
L
V
A
D
V
A
T
C
V
K
A
A
E
D
I
V
S
L
Y
R
----------------
56
HHSearch
54.60
26%
-101
- C1 -
3EI9
6
DAPAT_ARATH
A:
[52-427]
---------------------------------
K
---
Y
P
D
A
Q
V
I
S
L
G
I
G
D
T
T
E
P
I
P
E
V
I
T
S
A
M
A
K
K
A
H
E
L
S
TI
E
--
G
Y
S
G
---
Y
G
-
A
E
Q
G
A
K
P
L
R
A
A
I
A
K
T
F
Y
G
---
G
-
L
G
I
G
D
D
-
D
V
F
V
S
D
G
A
K
C
D
I
S
R
L
Q
V
M
F
-
G
S
--
N
V
----
T
I
A
V
Q
D
P
S
Y
P
A
Y
V
D
S
S
V
I
M
G
Q
T
GQFNTDVQKYGN
I
E
--
Y
M
R
C
T
P
E
---------
N
--------
G
F
F
P
D
L
S
T
V
------
G
R
-
T
D
I
I
F
F
C
S
P
N
N
P
T
G
A
A
A
T
R
E
Q
L
T
Q
L
V
E
F
A
K
K
N
G
S
I
I
V
Y
D
S
A
Y
A
M
Y
M
S
D
D
N
-
P
R
S
-
I
F
E
I
---
P
G
----
A
E
E
V
A
M
E
T
A
S
F
S
N
Y
A
G
F
T
G
V
R
L
G
W
T
V
I
P
K
K
L
L
Y
SDGFP
V
A
K
D
F
N
R
I
I
C
T
C
F
N
G
A
S
N
I
S
Q
A
G
A
L
A
C
L
T
-------
P
E
G
------
L
--
E
A
M
H
K
V
I
G
F
Y
K
E
N
T
N
I
I
I
D
T
F
T
S
L
G
Y
D
V
Y
G
G
K
N
A
P
Y
V
W
V
H
F
P
N
Q
---------------------
S
S
W
D
V
F
A
E
I
L
E
K
T
H
V
V
T
T
P
G
S
G
F
------
G
P
------
G
-----
G
E
G
F
V
R
V
S
A
F
G
H
R
E
N
I
L
E
A
C
R
R
F
K
Q
L
Y
K
H
---------------
50
HHSearch
54.51
23%
-93
- C1 -
1YIZ
3
?
A:
[17-428]
----------
K
R
Y
Q
G
S
T
-
K
S
V
W
V
E
Y
I
Q
L
---------
A
A
Q
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
A
N
S
----
P
DP
L
A
N
Q
---
Y
T
-
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
-
D
-
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
--
G
D
----
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
------------
P
R
--
F
I
P
L
K
P
N
---------
K
TGGTISSA
D
W
V
L
D
N
N
E
L
E
A
L
F
N
-
E
K
-
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
-
I
C
T
L
---
P
G
----
M
W
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
--------
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
V
G
F
E
-------
T
E
L
K
R
LKSP
E
--
C
Y
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
S
--------
K
VDLTQETDA
R
K
D
Y
R
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
------
Y
S
------
E
PNKHL
G
E
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
R
K
W
K
G
S
---------------
55
HHSearch
54.47
28%
-101
- C1 -
3JTX
5
?
A:
[27-395]
-------------------------------------
P
E
G
M
E
A
V
P
L
H
I
G
E
P
K
H
P
T
P
K
V
I
T
D
A
L
T
A
S
L
H
--------
E
L
E
K
---
Y
P
-
L
T
A
G
L
P
E
L
R
Q
A
C
A
N
W
L
K
R
R
Y
D
G
-
L
T
V
D
A
D
N
E
I
L
P
V
L
G
S
R
E
A
L
F
S
F
V
Q
T
V
L
N
P
----G
I
K
P
A
I
V
S
P
N
P
F
Y
Q
I
Y
E
G
A
T
L
L
G
G
G
E
------------
I
H
--
F
A
N
C
P
A
P
------------------
S
F
N
P
D
W
R
S
I
S
E
E
V
W
-
K
R
-
T
K
L
V
F
V
C
S
P
N
N
P
S
G
S
V
L
D
L
D
G
W
K
E
V
F
D
L
Q
D
K
Y
G
F
I
I
A
S
D
E
C
Y
S
E
I
Y
F
D
G
N
K
P
L
G
C
L
Q
A
A
A
Q
L
G
R
----
S
R
Q
K
L
L
M
F
T
S
L
S
K
R
S
N
V
P
G
L
R
S
G
F
V
A
G
D
A
E
L
L
K
--------
N
F
L
L
Y
R
T
Y
H
G
S
A
M
S
I
P
V
Q
R
A
S
I
A
A
W
D
-------
D
--------
E
--
Q
H
V
I
D
N
R
R
L
Y
Q
E
K
F
E
R
V
I
P
I
L
Q
Q
V
-
F
D
V
K
L
P
D
A
S
F
Y
I
W
L
K
V
P
D
G
---------------------
D
D
L
A
F
A
R
N
L
W
Q
K
A
A
I
Q
V
L
P
G
R
F
L
------
A
R
DTEQGN
P
-----
G
E
G
Y
V
R
I
A
L
V
A
D
V
A
T
C
V
K
A
A
E
D
I
V
S
L
Y
-----------------
3
PsiBlast_PDB
53.52
30%
-103
- C1 -
2O1B
1
?
A:
[49-392]
------------------------------------------
L
I
N
M
A
V
G
I
P
D
G
P
T
P
Q
G
I
I
D
H
F
Q
K
A
L
T
I
----
P
--
E
N
Q
K
---
Y
G
-
A
F
H
G
K
E
A
F
K
Q
A
I
V
D
F
Y
Q
R
Q
Y
-
N
-
V
T
L
D
K
E
D
E
V
C
I
L
Y
G
T
K
N
G
L
V
A
V
P
T
C
V
I
N
P
--
G
D
----
Y
V
L
L
P
D
P
G
Y
T
D
Y
L
A
G
V
L
L
A
D
G
K
------------
P
V
--
P
L
N
L
E
P
P
------------------
H
Y
L
P
D
W
S
K
V
D
S
Q
I
I
-
D
K
-
T
K
L
I
Y
L
T
Y
P
N
N
P
T
G
S
T
A
T
K
E
V
F
D
E
A
I
A
K
F
K
G
T
D
T
K
I
V
H
D
F
A
Y
G
A
F
G
F
D
A
-
K
N
P
S
-
I
L
A
S
---
E
N
----
G
K
D
V
A
I
E
I
Y
S
L
S
K
G
Y
N
M
S
G
F
R
V
G
F
A
V
G
N
K
D
M
I
Q
--------
A
L
K
K
Y
Q
T
H
T
N
A
G
M
F
G
A
L
Q
D
A
A
I
Y
A
L
N
-------
H
Y
-------
D
--
D
F
L
E
E
Q
S
N
V
F
K
T
R
R
D
R
F
E
A
M
L
A
K
A
D
L
P
F
V
H
A
K
G
G
I
Y
V
W
L
E
T
P
P
G
Y
--------------------
D
S
E
Q
F
E
Q
F
L
V
Q
E
K
S
I
L
V
A
P
G
K
P
F
------
G
E
------
N
-----
G
N
R
Y
V
R
I
S
L
A
L
D
D
Q
K
L
D
E
A
-------------------------
49
HHSearch
53.49
24%
-96
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[21-409]
--------------------------------------
A
D
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
----
D
--
N
M
N
Q
---
Y
T
-
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
-
Q
-
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
--
G
D
----
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
------------
P
V
--
F
I
P
L
R
S
K
PTDGMKWTS
S
--------
D
W
T
F
D
P
R
E
L
E
S
K
F
S
-
S
K
-
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
-
I
A
T
L
---
P
G
----
M
W
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
--------
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
I
K
R
M
D
D
P
-------
E
--
C
Y
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
A
DLSDMNSD
E
---------
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
------
C
D
------
S
KSKPH
F
E
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
I
F
R
A
W
------------------
7
PsiBlast_PDB
53.09
26%
-105
- C1 -
1GD9
2
?
A:
[18-376]
--------------------
L
F
D
I
A
A
G
M
K
------------
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
----
G
--
L
T
H
----
Y
G
-
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
-
G
-
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
--
G
E
----
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
------------
P
V
--
E
V
P
T
Y
E
E
---------
D
--------
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
-
D
K
-
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
-
I
A
S
L
---
D
G
----
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
--------
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
-------
D
E
-------
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
--
T
--------
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
------
G
K
------
A
-----
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
------------------------