@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5252: (2016-03-05 )
MIRLLNLTLQRGPQRLLEAAELTLHAGQKAGLIGANGAGKSSLFALLRGQLGQDAGDCLLPADWRIAHMRQEVDTLDRLAVDYVLDGDSRLREIQAALAVAEAAHDGSALARLHTELDNADGYTADARARKLLAGLGFSSEQMERRVGDFSGGWRMRLNLAQALMCPSDLLLLDEPTNHLDLDAILWLEEWLKGYPGTLVLISHDRDFLDAVVDHVVHLENRKLTLYRGGYSAFERTRAERLAQQQQAYEKQQAQRAHMESFIARFKAKATKARQAQSRIKALERLEELAPAHVDSPFNFSFRESDKISRPLLDLGEGRLGYGDKAVLEKVKLQLVPGARIGLLGPNGAGKSTLIKTLAGDLPELGGRLLRGENLAIGYFAQHQLDSLDPQASPLLHLQRIAPGEREQTLKDFLGGFDFRGVRVDEPVLNFSGGEKARLALALIAWQKPNLLLLDEPTNHLDLEMRLALTMALQEFSGAVLVVSHDRHLLKSTTDEFLLVADGRVVPFDGDLDDYARWLVDYRARKAPQAETAPGAPTERTDKRAQRQAAAALRQQLAPHKREADKLERELGGLHEKLAAIEARLGDSALYDVSRKDELRELLSEQSSLKVREGELEERWLEALETLEALQKELEASE
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.......--..10.-.-------.-.-....20...-.------...-.30........40...-...-------..50------.....--...60.----------..-.--.--...70-----------.--------..-..--.--.-.80.......-.90-.......-.100.......110.........120.......130....------------...140.......150.......160.....--.--.170.......180.-------......190..---.---..---..200........210..--.....------220.......230.......240-........250.......260.......270.......280.......290..---.....300-..--.......-310.......320--.--..--.....330.......340.......350....-...-360..---------------------.....370..------------------------.-----------....380...----------------------------------------.-------------------------------...------390---------------------------------------------------------------.--......---..----------------------------------------------------------400------------.-----------------------------------.-------.------.--.....410.......420.----......430.......440......---.---450.......460.......470....----..---.----480.......-490.....-..500----.------.--.......510.......520.......530....-.-..540-----.......550....-...560.......570.......580.....-..590.......600.......610.......620.......630......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
R
L
L
N
L
--
T
L
QR
G
-
P
-------
Q
-
R
-
L
L
E
A
A
E
L
T
L-H------AGQ-KA
G
L
IGANGA
G
K
S
S
L
F
-
A
L
L
-------
R
G
Q
L------GQDAG--DCLLPA----------
D
W
-
R
--
I
--
A
H
M
R
Q
-----------
E
--------
V
D
-
T
L
--
D
--
R
-
L
A
V
D
Y
V
LDG
D
-
S
R
L
-
R
E
I
Q
A
A
L
-
A
V
A
E
AAHD
G
S
A
L
--
A
R
L
H
T
ELDNADGYT
A
D
A
R
A
R
K
L
L
A
GL------------GF
S
S
E
Q
M
E
R
R
VGDFSG
G
W
R
M
R
L
N
L
A
Q
A
LMCP--S--
D
L
L
L
LDEPTNHL
D
L
D
-------
A
I
L
W
L
E
E
W
LKG---Y---P
G
---
T
L
V
L
-
I
SH
D
R
D
F
L
D
A
V
V
D
--
H
V
V
HL------EN
R
K
L
T
L
Y
RG
G
Y
S
A
F
E
R
T
R
A
E
R
--
L
A
Q
Q
Q
Q
A
Y
E
K
Q
Q
A
Q
R
A
H
M
E
S
F
I
A
R
F
K
A
K
A
T
K
A
R
Q
A
Q
S
R
I
K
A
L
E
R
L
E
E
L
A
P
AHV---DSPFNF---SF--RESDKIS-R
P
L
L
D
LGEGRLG---Y--G
D
--
K
A
V
L
E
K
V
K
L
Q
LVPG
A
R
I
G
L
LGPNGA
G
K
S
T
L
I
K
-
T
L
A
-GD
L
P
E
---------------------LGGRLLRGEN------------------------
L
-----------
A
I
G
Y
F
A
Q
HQL----------------------------------------D-------------------------------SLD------P-----------------------------------------------------------------Q--AS
P
L
L
H
---
L
Q
----------------------------------------------------------R--------------I-----------------------------------A-------P------
G
--
E
R
E
Q
T
L
K
D
F
LGGFDFRG
V
R
----VDEPVLNFSGG
E
K
A
R
L
A
L
A
L
I
AWQK---P---
N
L
L
L
LDEPTNH
L
D
L
E
M
R
L
A
L
T
M
A
L
Q
E
F----S
G
---
A
----
V
L
V
VSHD
R
H
L
-
L
K
STTD
E
F
-
L
L
V
------A------D--
G
R
V
VPFDG
D
L
D
D
Y
A
R
W
L
V
D
Y
R
ARKAPQAETAPGA-P-T
E
R
T
D
-----
K
R
A
Q
R
Q
A
A
A
A
L
R
Q
Q
-LAPH
K
R
E
A
D
K
L
E
R
E
L
G
G
L
H
E
K
L
A
A
I
E
A
RLGD-
S
A
LYDVS
R
K
D
E
L
R
E
L
L
S
E
QSSLKVRE
G
E
L
E
E
R
W
L
E
A
L
E
T
L
E
A
L
Q
K
E
LEASE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
94.63
31%
-110
- C- -
2IW3
7
EF3A_YEAST
A:
[440-979]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
--
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
-
R
A
I
-------
A
N
G
Q
------
V
--
D
G
--
F
P
T
-
Q
E
----------
E
C
-
R
--
T
--
V
Y
V
E
H
-----------
D
--------
I
D
-
G
T
H-
S
--
D
T
S
V
L
D
F
V
F
E
S
G
---------------------------------------
V
G
T
K
E
A
I
K
D
K
L
I
E
F
------------
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
---
C
---
G
I
---
T
S
I
T
-
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
-------
K
A
Y
E
E
-------
L
S
N
T
D
L
E
--------------------
F
K
--
F
P
E
P
-----
G
---
Y
----
L
--
E
G
V
K
T
K
Q
-
K
A
I
V
K
V
T
N
M
E
F
Q
---
Y
--
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
-
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
------------------------
C
-----------
R
I
A
Y
I
K
Q
H
A
F
----------------------------------------
A
-------------------------------
H
I
E
------
S
HL---------------------------------------------------------------
D
--
K
T
P
S
E
Y
---
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
-------
R
------
P
--
L
T
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
---
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
---
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
---
G
----
V
I
I
I
T
H
S
A
E
F
-
T
K
N
L
T
E
E
V
-
W
A
V
------
K
------
D
--
G
R
M
T
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.38
32%
-87
- C2 -
4FIN
13
ETTA_ECOLI
A:
[17-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
K
-
R
H
I
L
K
N
I
S
L
S
F
-
F
------
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
-
R
I
M
-------
A
G
I
D
------
K
D
I
E
G
--
E
A
R
P
Q
P
----------
D
I
-
K
--
I
--
G
Y
L
P
Q
-----------
E
P
Q
L
NPEHT
V
R
-
E
S
--
I
--
E
-
E
A
V
S
E
V
V
N
A
L
-
K
R
L
-
D
E
V
Y
A
L
Y
-
A
D
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
------------
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
--
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
V
A
W
L
E
R
F
L
H
D
---
F
---
E
G
---
T
V
V
A
-
I
T
H
D
R
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
--
L
A
Q
E
A
S
---
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
-
Q
G
T
K
----
K
G
K
A
R
-
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
---
F
I
--
P
P
G
P
R
L
G
-
D
K
V
L
E
V
S
N
L
R
K
S
---
Y
--
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
-
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
T
------------------------
V
-----------
K
L
A
S
V
D
Q
F
R
-----------------------------------------
D
-------------------------------
S
M
D
NSKT
V
W
E
-----------------------------------------------------------------
E
--
V
S
G
G
L
D
---
I
M
----------------------------------------------------------
K
--------------
I
--------------------------------------------------
G
--
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
----
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
---
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
------
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.31
32%
-73
- C2 -
3J5S
-
ETTA_ECOLI
D:
[23-539]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
K
-
R
H
I
L
K
N
I
S
L
S
F
-
F
------
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
-
R
I
M
-------
A
G
I
D
------
K
D
I
E
G
--
E
A
R
P
Q
P
----------
D
I
-
K
--
I
--
G
Y
L
P
Q
-----------
E
PQLNPEHT
V
R
-
E
S
--
I
--
E
-
E
A
V
S
E
V
V
N
A
L
-
K
R
L
-
D
E
V
Y
A
L
Y
-
A
D
P
D
A
D
F
D
K
L
A
A
EQ
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
------------
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
--
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
V
A
W
L
E
R
F
L
H
D
---
F
---
E
G
---
T
V
V
A
-
I
T
H
D
R
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
--
L
A
Q
E
A
S
---
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
-
Q
G
T
K
G
R
Q
S
K
G
K
A
R
-
L
A
R
F
E
E
L
N
S
T
E
Y
QKR
N
E
T
N
E
L
---
F
I
--
P
P
G
P
R
L
G
-
D
K
V
L
E
V
S
N
L
R
K
S
---
Y
--
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
-
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
T
------------------------
V
-----------
K
L
A
S
V
D
Q
F
R
-----------------------------------------
D
-------------------------------
S
M
D
NSKTVW
E
-----------------------------------------------------------------
E
--
V
S
G
G
L
D
---
I
M
----------------------------------------------------------
K
--------------
I
--------------------------------------------------
G
--
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
----
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
---
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
------
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.34
24%
-54
- C2 -
1YQT
4
?
A:
[43-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
-
K
------
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
-
K
I
L
-------
A
G
Q
L
IPNLCG
D
N
D
S
W
--
D
G
V
I
R
A
-----------
F
-
R
--
G
--
N
E
L
Q
N
-----------
Y
--------
F
E
-
K
L
--
K
-----------
N
G
E
-
I
R
P
-
V
V
K
P
Q
Y
V
-
D
L
I
P
K
A
V
K
G
K
V
I
--
E
L
L
K
----
K
A
D
---
E
T
G
K
L
E
E
V
V
K
A
L
------------
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
-------------
S
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
------
E
P
-------
G
V
Y
G
I
F
S
Q
P
K
G
T
R
--
N
G
I
N
E
-------
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
-
I
E
R
-
E
T
L
----
V
---
T
Y
P
------------------
R
L
V
K
D
Y
G
S
F
R
L
---------------
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
-
G
V
E
E
P
---------------------
T
E
G
K
I
--
E
W
D
------------------------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
----------------------------------------
A
-------------------------------
D
Y
E
------
G
-----------------------------------------------------------------
T
--
V
Y
E
L
L
S
K
I
D
A
S
----------------------------------------------------------
K
--------------
L
-----------------------------------
N
-------
S
------
N
--
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
E
----
V
N
E
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
-----------------------
R
L
M
V
F
E
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
-
I
-
T
F
R
R
D
PDTG
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
63.68
21%
-45
- C2 -
3J16
4
RLI1_YEAST
B:
[1-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPFD
A
I
Q
I
I
N
L
PT
N
L
E
A
H
-
V
-------
T
-
H
-
R
Y
S
A
N
S
F
K
L
-
H
R
L
P
T
P
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
-
K
I
L
-------
A
G
K
Q
------
K
P
N
L
G
--
R
F
D
D
P
P
----------
E
W
-
Q
--
E
--
I
I
K
Y
F
-----------
R
--------
G
S
-
E
L
--
Q
--
N
-
Y
-
F
T
K
M
L
E
D
D
-
I
K
A
-
I
I
K
P
Q
Y
V
-
D
N
I
P
R
A
I
K
G
P
-
V
--
Q
K
V
G
E
L
L
K
L
R
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
------------
Q
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
R
L
N
A
A
Q
I
I
R
S
---
L
---
L
A
P
T
K
Y
V
I
C
-
V
E
H
D
L
S
V
L
D
Y
L
S
D
--
F
V
C
I
I
------
Y
G
V
P
-----
S
V
Y
G
V
V
-------------
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
---
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
------------------
S
A
S
R
A
F
S
-
Y
P
S
L
K
K
T
Q
G
D
F
-------------
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
-
G
A
L
K
P
---------------------
D
E
G
Q
D
--
I
P
K
------------------------
L
-----------
N
V
S
M
K
P
Q
K
I
A
----------------------------------------
P
-------------------------------
K
F
P
------
G
-----------------------------------------------------------------
T
--
V
R
Q
L
F
F
---
K
K
----------------------------------------------------------
I
--------------
R
-----------------------------------
G
-------
Q
------
F
--
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
I
-----
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
---
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
----------------------
F
E
G
I
P
S
K
N
A
H
------------------------------------------------------
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
-
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
62.45
22%
-71
- C2 -
3BK7
4
?
A:
[84-547]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
V
N
L
--
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
-
A
F
V
L
Y
R
L
P
I
V
K
------
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
-
K
I
L
-------
A
G
Q
L
------
I
P
N
L
C
--
E
D
N
D
S
W
----------
D
--
N
--
V
--
I
R
A
F
R
-----------
G
--------
N
E
--
L
--
Q
--
N
--
Y
F
E
R
L
K
N
G
E
-
I
R
P
-
V
V
K
P
Q
Y
V
-
D
L
L
--
P
K
A
--
V
K
--
G
K
V
R
E
---
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
------------
E
L
E
-
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
---
L
A
N
E
G
K
---
A
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
--
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
--
N
G
---------------
I
N
E
F
L
Q
G
Y
L
K
D
E
------
N
V
R
F
R
P
Y
----------------
E
I
R
F
---
T
K
LS
E
R
V
D
V
E
R
-
E
T
L
V
E
Y
P
R
L
V
K
D
---
Y
--
G
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
-
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
L
-------------------------------------
T
V
A
Y
K
P
Q
Y
I
K
-------------------------------------------------------------------------
A
E
------
Y
-----------------------------------------------------------------
E
--
G
T
V
Y
E
L
---
L
S
----------------------------------------------------------
K
--------------
I
-----------------------------------
D
-------
S
------
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
-
L
----
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
V
F
------
E
------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.33
23%
-42
- C2 -
3J15
2
?
B:
[103-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
-
K
I
L
-------
A
G
Q
L
-----------------------------------
I
--
P
N
L
C
E
-----------
D
--------
N
D
-
S
W
--
D
--
N
-
V
I
R
A
F
-------
R
G
-
N
E
L
Q
N
Y
F
----
E
R
L
K
N
G
E
I
R
--
P
V
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
K
V
R
E
L
L
K
K
V
DEVGK
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
---
L
---
A
N
E
G
K
A
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
------
E
P
-------
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
--
F
R
P
Y
E
I
R
F
T
-------------
K
L
S
E
R
V
D
V
E
R
E
T
L
V
---
E
Y
P
------------------
R
L
V
K
D
Y
G
S
F
K
L
---------------
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
-
G
V
E
E
P
---------------------
T
E
G
K
V
--
E
W
D
------------------------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
----------------------------------------
A
-------------------------------
E
Y
E
------
G
-----------------------------------------------------------------
T
--
V
Y
E
L
L
S
K
I
D
S
S
----------------------------------------------------------
K
--------------
L
-----------------------------------
N
-------
S
------
N
--
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
--------
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
-----------------------
R
L
I
V
F
E
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
G
-
I
-
T
F
R
R
D
PDSG
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
-
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.31
23%
-50
- C2 -
3BK7
2
?
A:
[117-600]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
-
K
I
L
-------
A
G
Q
L
-----------------------------------
I
--
P
N
L
C
E
-----------
D
--------
N
D
-
S
W
--
D
--
N
-
V
I
R
A
F
-------
R
G
-
N
E
L
Q
N
Y
F
----
E
R
L
K
N
G
E
I
R
--
P
V
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
K
V
R
E
L
L
K
K
V
DEVGK
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
---
L
---
A
N
E
G
K
A
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
------
E
P
-------
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
--
F
R
P
Y
E
I
R
F
T
-------------
K
L
S
E
R
V
D
V
E
R
E
T
L
V
---
E
Y
P
------------------
R
L
V
K
D
Y
G
S
F
K
L
---------------
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
-
G
V
E
E
P
---------------------
T
E
G
K
V
--
E
W
D
------------------------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
----------------------------------------
A
-------------------------------
E
Y
E
------
G
-----------------------------------------------------------------
T
--
V
Y
E
L
L
S
K
I
D
S
S
----------------------------------------------------------
K
--------------
L
-----------------------------------
N
-------
S
------
N
--
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
--------
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
-----------------------
R
L
I
V
F
E
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
G
-
I
-
T
F
R
R
D
PDSG
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
-
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
60.27
23%
-60
- C2 -
1YQT
4
?
A:
[25-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
--
V
H
R
Y
G
-
V
N------
A
-
F
-
V
L
Y
R
L
P
-
V
V
-
K
------
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
-
K
I
L
-------
A
G
Q
L
------
I
P
N
L
C
GD
N
D
S
W
D
G
----------
V
I
-
R
--
A
F
R
G
N
E
L
Q
-----------
N
--------
Y
F
E
K
L
--
K
--
N
G
E
I
R
P
V
V
K
P
Q
Y
-----
V
D
L
I
P
K
----
A
-------
V
K
--
G
K
V
I
---
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
------------
E
L
E
-
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
---
G
K
---
S
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
--
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
--
N
---------------
G
I
N
E
F
L
R
G
Y
L
K
----
D
E
N
--
V
R
---
F
R
P
Y
E
I
K
-
F
T
K
T
---
G
E
R
V
------------
E
I
E
R
-
E
T
L
V
T
Y
P
R
L
V
K
D
---
Y
--
G
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
-
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
-------------------------------------
T
V
A
Y
K
P
Q
Y
I
K
-------------------------------------------------------------------------
A
D
------
Y
-----------------------------------------------------------------
E
--
G
T
V
Y
E
L
---
L
S
----------------------------------------------------------
K
--------------
I
-----------------------------------
D
-------
A
------
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
-
L
----
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
M
V
F
------
E
------
G
--
E
P
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
59.40
27%
-96
- C2 -
2IWH
8
EF3A_YEAST
A:
[441-774]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
-------
N
G
Q
V
------
D
G
--------
F
P
T
QE--------
E
C
-
R
--
T
--
V
Y
V
E
H
-----------
D
--------
I
D
-
G
T
HS
D
--
T
-
S
V
L
D
F
V
F
-----------
E
S
G
V
-
G
T
K
E
A
I
K
D
K
---------------------------
L
I
E
F
------------
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
---
C
---
G
I
---
T
S
I
T
-
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--------------------------------
K
C
P
A
A
K
A
------------
Y
E
E
L
--
S
N
T
---
D
L
E
F
K
F
P
EP
G
Y
--
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
---
Y
PG
T
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
-
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
------------------------
C
-----------
R
I
A
Y
I
K
Q
H
A
F
----------------------------------------
A
-------------------------------
H
I
E
------
S
-----------------------------------------------------------------
H
LD
K
T
P
S
E
Y
---
I
Q
W
---------------------------------------------------------
R
--------------
F
-----------------------------------
Q
-------
T
------
G
--
E
D
R
E
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.30
27%
-92
- C2 -
2IX3
6
EF3A_YEAST
A:
[441-774]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
-------
N
G
Q
V
------
D
G
--------
F
P
T
QE--------
E
C
-
R
--
T
--
V
Y
V
E
H
-----------
D
--------
I
D
-
G
T
HS
D
--
T
-
S
V
L
D
F
V
F
-----------
E
S
G
V
-
G
T
K
E
A
I
K
D
K
---------------------------
L
I
E
F
------------
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
---
C
---
G
I
---
T
S
I
T
-
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--------------------------------
K
C
P
A
A
K
A
------------
Y
E
E
L
--
S
N
T
---
D
L
E
F
K
F
P
EP
G
Y
--
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
---
Y
PG
T
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
-
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
------------------------
C
-----------
R
I
A
Y
I
K
Q
H
A
F
----------------------------------------
A
-------------------------------
H
I
E
------
S
-----------------------------------------------------------------
H
LD
K
T
P
S
E
Y
---
I
Q
W
---------------------------------------------------------
R
--------------
F
-----------------------------------
Q
-------
T
------
G
--
E
D
R
E
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.96
26%
-96
- C2 -
2IW3
6
EF3A_YEAST
A:
[441-773]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
-------
N
G
Q
V
------
D
G
--------
F
P
T
QE--------
E
C
-
R
--
T
--
V
Y
V
E
H
-----------
D
--------
I
D
-
G
T
HS
D
--
T
-
S
V
L
D
F
V
F
-----------
E
S
G
V
-
G
T
K
E
A
I
K
D
K
---------------------------
L
I
E
F
------------
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
---
C
---
G
I
---
T
S
I
T
-
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--------------------------------
K
C
P
A
A
K
A
------------
Y
E
E
L
--
S
N
T
---
D
L
E
F
K
F
P
EP
G
Y
--
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
---
Y
PG
T
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
-
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
------------------------
C
-----------
R
I
A
Y
I
K
Q
H
A
F
----------------------------------------
A
-------------------------------
H
I
E
------
S
-----------------------------------------------------------------
H
LD
K
T
P
S
E
Y
---
I
Q
W
---------------------------------------------------------
R
--------------
F
-----------------------------------
Q
-------
T
------
G
--
E
D
R
E
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
57.94
27%
-87
- C2 -
1OXX
21
?
K:
[2-230]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
---
F
--
K
K
GK
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
-
I
I
A
-
G
L
D
V
P
---------------------
S
T
G
E
L
Y
F
D
D
R
LVASNGKLIVPPED----------
R
-----------
K
I
G
M
V
F
Q
T
W
-------------------------------------------------------------------------
A
L
Y
------
P
-----------------------------------------------------------------
N
--
L
T
A
F
E
N
---
I
A
----------------------------------------------------------
F
--------------
P
-----------------------------------
L
-------
T
NMKMSK
E
--
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
----
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
---
P
---
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
---
T
----
L
L
V
V
S
H
D
P
A
D
-
I
F
A
I
A
D
R
V
-
G
V
L
------
V
------
K
--
G
K
L
V
Q
V
-
G
K
P
E
D
L
Y
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.90
23%
-56
- C2 -
3J16
2
RLI1_YEAST
B:
[99-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
-
R
------
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
-
K
I
L
-------
A
G
K
Q
------
K
P
N
L
G
--
R
F
D
D
P
P
----------
E
W
-
Q
E
I
I
--
K
Y
F
R
G
SEL
Q
N
Y
F
T
K
M
L
E
--------
D
D
-
I
K
--
A
--
I
-
I
K
P
Q
Y
V
---
D
-
N
I
P
-
R
A
I
K
G
P
V
Q
K
V
G
E
-------
L
--
L
K
L
R
M
E
K
S
P
E
D
V
----
K
R
Y
I
K
I
L
Q
----------------
L
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
R
L
N
A
A
Q
I
I
R
S
---
L
L
A
-
P
T
---
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
--
F
V
C
I
I
------
Y
G
V
P
-
S
V
Y
--
G
V
V
T
L
P
A
S
V
R
E
G
--
I
---------
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
----
A
T
E
D
L
Q
N
D
S
A
S
R
A
---
F
S
Y
P
S
L
---
K
K
--
T
Q
G
D
F
V
-----
L
N
V
E
E
G
E
-----
F
--
S
D
--
S
E
I
L
V
-------------
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
-
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
K
L
N
------------------------
V
-----------
S
M
---
K
P
Q
K
I
----------------------------------------
A
-------------------------------
P
K
F
------
P
-----------------------------------------------------------------
G
--
T
V
R
Q
L
F
---
F
K
----------------------------------------------------------
K
--------------
I
------------------------------------------------------
R
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
IDDI
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
57.51
17%
-67
- C2 -
3OZX
5
?
A:
[4-463]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
--
I
H
R
Y
K
V
N
-------
G
-
F
-
K
L
F
G
L
P
T
-
P
-
K
------
N
N
T
-
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
-
K
I
L
-------
A
G
E
I
------
I
P
N
F
G
--
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R
G
K
-
E
--
I
--
Y
N
Y
F
K
-----------
E
--------
L
Y
--
S
--
N
--
E
L
K
I
V
H
K
I
Q
Y
V
E
-
Y
--------
A
--
S
K
F
-------
L
K
--
G
T
V
N
E
---
I
L
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
------------
N
M
T
-
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
--
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
-------
E
R
M
N
M
A
K
A
I
R
E
---
L
L
K-
N
K
---
Y
V
I
V
-
V
D
H
D
L
I
V
L
D
Y
L
T
D
--
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
I
---------------------
N
N
F
L
K
G
Y
L
P
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
--------------------------------
L
-
K
T
K
M
K
W
T
K
I
I
K
K
---
L
--
G
D
---
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
-
I
L
V
-
G
E
I
T
A
---------------------
D
E
G
S
V
T
P
E
K
-------------------------
Q
-----------
I
L
S
Y
K
P
Q
R
I
F
-------------------------------------------------------------------------
P
N
------
Y
-----------------------------------------------------------------
D
--
G
T
V
Q
Q
Y
---
L
E
----------------------------------------------------------
N
--------------
A
-----------------------------------
S
-------
K
DAL---
S
--
T
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
R
-
L
----
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
---
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
---
V
----
T
F
I
I
D
H
D
L
S
I
-
H
D
Y
I
A
D
R
I
-
I
V
F
------
K
------
G
--
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
57.39
20%
-52
- C2 -
3J16
2
RLI1_YEAST
B:
[82-560]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
--
T
H
R
Y
S
-
A
-------
N
S
F
-
K
L
H
R
L
P
-
T
P
-
R
------
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
-
K
I
L
-------
A
G
K
Q
------
K
P
N
L
G
--
R
F
D
D
P
P
----------
E
W
Q
E
I
-
I
--
K
Y
F
-
R
-----------
G
--------
S
E
-
L
Q
--
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
---------
I
K
G
P
V
--
Q
K
V
G
E
-
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
------------
Q
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
R
L
N
A
A
Q
I
I
R
S
---
L
L
A
P
T
K
---
Y
V
I
C
-
V
E
H
D
L
S
V
L
D
Y
L
S
D
--
F
V
C
I
I
------
Y
G
V
P
S
V
Y
--
G
V
V
T
L
P
A
S
V
R
E
G
--------------------
I
N
I
F
L
D
G
H
I
P
----
A
E
N
L
R
F
R
T
---
E
A
L
Q
F
R
I
A
-------
D
A
T
E
----
D
L
----
Q
N
D
S
A
-
S
R
A
F
S
Y
P
S
L
K
K
T
---
Q
--
G
---
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
-
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
--
K
------------------------
L
-----------
N
V
S
M
K
P
Q
K
I
A
----------------------------------------
P
---------------------------------
K
------
F
-----------------------------------------------------------------
P
--
G
T
V
R
Q
L
---
F
F
----------------------------------------------------------
K
--------------
K
-----------------------------------
I
-------
R
------
G
QF
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-
I
----
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
------
E
------
G
I
P
S
K
N
A
H
-
A
R
A
P
E
S
L
L
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
55.91
23%
-62
- C2 -
2VF7
3
?
A:
[363-828]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
H
L
------------
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
LF
G
--
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
-------
D
T
E
A
L
L
S
A
L
E
N
---
L
K
R
G
G
N
---
S
L
F
V
-
V
E
H
D
L
D
V
I
R
R
-
A
D
--
W
L
V
D
V
G
PEAGE
K
G
G
E
I
L
-
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
-------------------
T
G
Q
Y
L
--------
F
A
------------
D
R
----
H
-
T
----
E
-----------
P
H
T
P
R
E
P
-
A
G
W
L
E
L
N
G
V
T
------------
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
-
Q
A
L
V
D
A
L
A
A
H
F
GQ-------------------
G
S
A
R
L
G
G
D
LAQIT
R
L
V
R
V
D
QKPIGRTPRSN
M
A
T
-----------
Y
T
G
L
F
D
Q
V
R
K
-------------------------------------------------------------------------
L
F
------
A
A
T
P
L
A
K
K
R
GYNAGRFSFNVKGGRCEHCQGEGWVMVELLFL
P
S
V
Y
A
P
CPVCHGTRYN
A
E
T
L
E
VEYR
G
--
K
N
I
A
D
V
---
L
A
----------------------------------------------------------
L
--------------
T
-----------------------------------
V
D
E
A
H
D
F
F
A
D-----
E
--
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
----
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
GRG
G
---
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
---
T
----
V
I
A
V
E
H
K
M
Q
V
-
V
A
-
A
S
D
W
V
-
L
D
I
G
PGAGE
D
------
G
--
G
R
L
V
A
-
Q
G
T
P
A
E
V
A
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
55.26
22%
-65
- C2 -
2R6F
3
?
A:
[487-943]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
------------
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
--
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
-------
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
---
G
N
---
T
L
I
V
-
V
E
H
D
E
D
T
M
L
-
A
A
D
--
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
---------
L
T
----------
G
Q
Y
L
S
--------
G
K
---
K
----
F
I
------
P
I
P
--------------
A
---
E
R
R
R
P
D
-
G
R
W
L
E
V
V
G
A
R
------------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
-
E
V
L
-
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
I
D
I
D
Q
S
------------------------
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
------
L
-----------------------------------------------------------------
D
--
M
T
V
E
D
A
---
L
D
----------------------------------------------------------
F
--------------
F
-----------------------------------
A
-------
S
------
I
--
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
----
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
---
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
---
T
----
V
L
V
I
E
H
N
L
D
V
-
I
K
-
T
A
D
Y
I
-
I
D
L
------
G
PEGGDR
G
--
G
Q
I
V
A
-
V
G
T
P
E
E
V
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
53.66
19%
-35
- C2 -
1YQT
4
?
A:
[24-538]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
--
C
V
H
R
Y
-
G
-------
V
-
N
-
A
F
V
L
Y
R
L
P
V
-
V
------
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
-
K
I
L
-------
A
G
Q
L
------
I
P
N
L
C
--
G
-------------------------
D
N
D
S
-----------
W
--------
D
G
-
V
I
--
R
--
A
-
F
R
G
N
E
L
Q
N
Y
F
-
E
K
L
-
K
N
G
E
I
R
P
-
V
V
K
P
Q
Y
V
D
L
I
P
K
--
A
V
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
------------
E
L
E
-
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
N
A
A
R
A
I
R
R
---
L
---
S
E
E
G
K
S
V
L
V
-
V
E
H
D
L
A
V
L
D
Y
L
S
D
--
I
I
H
V
V
------
Y
G
-------
E
P
G
V
Y
G
I
F
S
Q
P
K
G
--
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
E
R
---------------------------------------
E
T
L
V
T
Y
P
R
L
V
K
D
---
Y
--
G
S
--
F
R
L
E
V
-
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
-
V
E
E
P
T
---------------------
E
G
K
I
E
W
D
L
T
----------------------------------------
V
A
Y
K
P
Q
Y
----------------------------------------
I
-------------------------------
K
A
D
------
Y
-----------------------------------------------------------------
E
GT
V
Y
E
L
L
S
---
K
I
----------------------------------------------------------
D
--------------
A
-----------------------------------
S
-------
K
------
L
--
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
-----
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
---
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
-
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
------
E
--
P
G
K
------------------------
Y
G
R
A
L
P
P
M
G
M
R
-----------------------------------------------------
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
P
D
T
G
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
K
E
K
G
E
Y
Y
Y
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
52.91
18%
-41
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
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