@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : C2YU92_BACCE: (2019-01-26 )
MDISIIAAQLVKEKVISHNPNSVKALNGGTTSTVYLLDEKYVVKLNEAEVIREEAHFLSFYEGNTLFSKLLYKEPLHTYIVYSFLEGSTWCEQGHKRSTLRTLVKEVINKYKIVPEADGWGWKENPVQSWNEFLTTNVMEAYENVRRYISEEEYRTVLKLANRDAGVNQPFLLHGDCGFHNFIFRENRLHGVIDPLPVLGEPLYDLIYAFCSTPEDLTKETIAYAMKQCLFHKKERDLYEEIVIGLYLRIDTCLRHHPKDLEEYLVAWRYWMDEINPAL
Atome Classification :
(21 SA)
----------..-.......10......-.------------.20.--.....--.--.30.......---.------------.40.---...-----...-----.-----50-----..----..--....-.60..-.---..-.---------..70--...--.-----.--..----------------------.80----.......-.-.----90--------------.-...------.------....100--------........-110..-----.....120.-..--.-----..-----------..130....--------------.--..140----.---.--...--.--.--..150--------.--..---------.---------.....--160-.-----.--....-..170-------..-......180..--..----.------..190..-.-.-..-.200..----..---...--210..--------.---------------.--------------------...-..220--------........230----------....---...240---.......--250.....------------.---------.----260---.........270.......--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------M
D
-
I
S
I
I
A
A
Q
L
V
K
E
K
V
IS-H------------NPNS--
V
K
ALN--G--GT-
T
S
T
V
Y
L
L---D------------
E
K
Y
V
---
V
KL-----
N
E
A
-----
E
-----
V
------
I
R
----
E
E--A
H
F
L
-
S
F
YE
G
-
N
---
T
L
-
F
---------
S
K
L
L
--
Y
KE--P-----
L
--
H
T
----------------------
Y
I
-----
V
Y
S
FLEG-
S
-
T
----
W
---------------
C
-
E
QG------H------K
R
S
T
L
R
---------
T
L
V
K
E
V
I
N
-KYKIV-----PEADGWG-W-KE--
N
-----
P
V
-----------
Q
S
W
N
E
F
L
T
T
--------------
N
--
V
M
E
------
A
---
Y
--
E
N
V
--
R
--
R
--
Y
I
S
----------
E
--
E
E
---------
Y
---------
R
T
V
L
K
--
L
A--N-----R--DAGV-NQ
P
F
--------
L
L
-HGDCGFHN
F
I
F
--RE----N------RLHGVID-P-L-PV-LG
E
P
L
Y
----
D
L
---
I
Y
A
--
F
--CS--------
T
---------------
P
--------------------
E
D
L
-
T
K
E
T
---------
I
A
Y
A
M
K
Q
C
L
F
H
----------
K
K
E
R
---
D
L
Y
E
E
I
---
V
I
G
L
Y
L
R
--
I
D
T
C
L
RH
H
------------
P
---------
K
----
D
-----
L
E
E
Y
L
V
A
W
R
Y
W
M
D
EINPAL--------------------------------
18
Fugue
82.37
17%
-17
- C3 -
-
3HAM
3
?
A:
[1-299]
-------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
-
I
------------
K
I
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
P
KR
D
-
S
V
R
-----
I
-----
S
------
Q
K
----
R
E
--
F
E
L
Y
-
R
F
L
E
N
-
C
---
K
L
S
Y
---------
Q
I
P
A
--
V
V
Y
--
Q
-----
S
--
D
R
----------------------
F
N
-----
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
-
Y
E
Q
Y
H
K
LS
E
K
------
E
K
D
A
L
A
---------
Y
D
E
A
T
F
L
K
-
E
L
H
S
I
EIDCS
V
S
L
F
S
D
A
-
L
-
V
N
--
K
-----
K
D
-----------
K
F
L
Q
D
K
K
L
L
--------------
I
--
S
I
L
------
E
---
K
--
E
Q
L
--
L
--
T
--
D
E
M
----------
L
--
E
H
---------
I
---------
E
T
I
Y
E
--
N
I
L
N
N
-----
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
F
G
-
D
-
F
N
-
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
---------------
T
--------------------
D
D
F
-
G
K
E
F
---------
G
R
K
V
L
K
Y
Y
Q
H
K
----------
A
P
E
V
---
A
E
R
K
A
E
---
L
N
D
V
Y
W
S
--
I
D
Q
I
I
Y
G
Y
------------
E
---------
R
----
K
-----
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
FIF-----------------------------
35
HHSearch
78.90
16%
-44
- C3 -
-
3TDW
1
?
A:
[4-253]
-------------
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
-
I
------------
S
I
Q
S
--
V
E
S
L
G
--
E
--
G
F
-
R
N
Y
A
I
L
V
---
N
------------
G
D
W
V
---
F
R
F
-----
P
K
S
Q
Q
G
A
-
D
-----
E
------
L
N
----
K
E
--
I
Q
L
L
-
P
L
L
V
G
C
V
---
K
V
-
N
I--------
P
Q
Y
V
--
Y
I
G
--
K
R
SD--
G
--
N
P
----------------------
F
V
-----
G
Y
R
K
V
Q
G
-
Q
-
I
----
L
---------------
G
-
E
D
G
------
M
A
V
LP
D
D
A
K
D
R
L
A
---------
L
Q
L
A
E
F
M
N
-
E
L
S
A
F
-----
P
V
E
T
A
-
I
-
S
-
A
G
--
V
-----
P
V
-----------
T
N
L
K
N
K
I
L
L
--------------
L
--
S
E
A
------
V
---
E
--
D
Q
V
--
F
--
P
--
L
L
D
----------
E
--
S
L
---------
R
---------
D
Y
L
T
L
--
R
F
--
Q
S
Y
M
T
-
H
P-
V
Y
T
R
-
Y
T
P
R
--------
L
I
-
H
G
D
L
S
P
D
H
F
L
T
--
N
L
NSRQ
T
------
P
L
T
G
I
I
D
-
F
-
G
D
A
A
-
I
S
D
P
D
Y
----
D
Y
---
V
Y
L
--
L
--
E
D
--------
C
---------------
G
--------------------
E
L
F
--
T
R
Q
---------
V
M
A
Y
R
G
E
V
----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.43
26%
-7
- C3 -
-
4DCA
1
?
A:
[40-258]
--------------------------------------------
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
-----
P
K
R
-----
D
-----
S
------
V
R
I
S
Q
K
R
E
--
L
E
L
Y
-
R
F
L
E
N
------------------
C
K
L
S
--
Y
Q
I
--
P
-----
A
--
V
V
----------------------
Y
Q
SDR
F
N
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
Y
E
Q
Y
------
H
------
K
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
----
H
S
I
E
-----
I
D
C
S
V
S
L
-
F
-
S
D
--
A
-----
L
V
-----------
N
K
K
D
K
F
L
Q
D
--------------
K
K
L
L
I
S
------
I
---
L
--
E
K
E
--
Q
--
L
--
L
T
D
----------
E
M
L
E
H
---------
I
---------
E
T
I
Y
E
N
I
L
S
--
N
-----
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
-
F
-
G
-
D
F
N
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
---------------
T
--------------------
D
D
F
-
G
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.03
26%
-2
- C3 -
-
3UZR
5
?
A:
[40-258]
--------------------------------------------
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
-----
P
K
R
-----
D
-----
S
------
V
R
I
S
Q
K
R
E
--
L
E
L
Y
-
R
F
L
E
N
------------------
C
K
L
S
--
Y
Q
I
--
P
-----
A
--
V
V
----------------------
Y
Q
SDR
F
N
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
Y
E
Q
Y
------
H
------
K
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
----
H
S
I
E
-----
I
D
C
S
V
S
L
-
F
-
S
D
--
A
-----
L
V
-----------
N
K
K
D
K
F
L
Q
D
--------------
K
K
L
L
I
S
------
I
---
L
--
E
K
E
--
Q
--
L
--
L
T
D
----------
E
M
L
E
H
---------
I
---------
E
T
I
Y
E
N
I
L
S
--
N
-----
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
-
F
-
G
-
D
F
N
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
---------------
T
--------------------
D
D
F
-
G
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.04
26%
-7
- C3 -
-
3HAV
2
?
A:
[19-240]
--------------------------------------------
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
-----
P
K
R
-----
D
-----
S
------
V
R
I
S
Q
K
R
E
--
F
E
L
Y
-
R
F
L
E
N
------------------
C
K
L
S
--
Y
Q
I
--
P
-----
A
--
V
V
----------------------
Y
Q
SDR
F
N
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
Y
E
Q
Y
------
H
------
K
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
----
H
S
I
E
-----
I
D
C
S
V
S
L
-
F
-
S
D
--
A
-----
L
V
-----------
N
K
K
D
K
F
L
Q
D
--------------
K
K
L
L
I
S
------
I
---
L
--
E
K
E
--
Q
--
L
--
L
T
D
----------
E
M
L
E
H
---------
I
---------
E
T
I
Y
E
N
I
L
N
--
N
-----
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
-
F
-
G
-
D
F
N
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
---------------
T
--------------------
D
D
F
-
G
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.48
26%
-4
- C3 -
-
3HAM
3
?
A:
[19-237]
--------------------------------------------
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
-----
P
K
R
-----
D
-----
S
------
V
R
I
S
Q
K
R
E
--
F
E
L
Y
-
R
F
L
E
N
------------------
C
K
L
S
--
Y
Q
I
--
P
-----
A
--
V
V
----------------------
Y
Q
SDR
F
N
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
Y
E
Q
Y
------
H
------
K
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
----
H
S
I
E
-----
I
D
C
S
V
S
L
-
F
-
S
D
--
A
-----
L
V
-----------
N
K
K
D
K
F
L
Q
D
--------------
K
K
L
L
I
S
------
I
---
L
--
E
K
E
--
Q
--
L
--
L
T
D
----------
E
M
L
E
H
---------
I
---------
E
T
I
Y
E
N
I
L
N
--
N
-----
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
-
F
-
G
-
D
F
N
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
---------------
T
--------------------
D
D
F
-
G
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
70.31
16%
-4
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--------------
T
D
I
T
E
D
E
L
R
N
F
L
T
Q
-
Y
------------
D
V
G
S
--
L
T
S
Y
K
--
G
--
I
A
-
E
N
S
N
F
L
L
---
H
T
T
K
---------
D
P
L
I
---
L
T
L
-----
Y
E
K
-----
K
-----
N
------
D
L
----
P
F
--
F
L
G
L
M
Q
H
L
A
A
-
K
---
G
L
-
S
C
P
L
P
L
P
R
KD
G
E
L
L
--
G
E
L
--
S
-----
G
--
R
P
----------------------
A
A
-----
L
I
S
F
L
E
G
M
W
-
L
-----------------------
R
K
------
P
------
E
A
K
H
C
R
---------
E
V
G
K
A
L
A
A
M
H
L
A
-------
S
E
G
F
E
I
K
-
R
-
P
N
--
A
-----
L
S
-----------
V
D
G
W
K
V
L
W
D
--------------
K
--
S
E
E
------
R
---
A
--
D
E
V
--
E
--
K
--
G
L
R
----------
E
--
E
I
---------
R
---------
P
E
I
D
Y
--
L
A
--
A
-----
H
--
W
P
K
D
-
L
P
A
G
--------
V
I
-
H
A
D
L
F
Q
D
N
V
F
F
--
L
G
----
D
------
E
L
S
G
L
I
D
F
Y
-
F
-
A
C
-
N
D
L
L
A
Y
----
D
V
---
S
I
C
--
L
--
N
A
WCFEKDGA
Y
---------------
N
--------------------
V
T
K
-
G
K
A
L
---------
L
E
G
Y
Q
S
V
R
P
L
S
----------
E
A
E
L
---
E
A
L
P
L
L
---
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
TPAGALVVKKD
P
---------
L
----
E
-----
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A-------------------------------
22
Fugue
68.05
16%
31
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------AK
M
R
-
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
-
K
------------
D
T
E
----------
G
--
M
S
-
P
A
K
V
Y
K
L
V
G
E
N
------------
E
N
L
Y
---
L
K
M
-----
T
D
S
-----
R
-----
Y
KGTTYD
V
E
----
R
E
--
K
D
M
M
-
L
W
L
E
G
-
K
---
L
P
-
V
---------
P
K
V
L
--
H
F
E
--
R
-----
H
DG
W
S
----------------------
N
L
-----
L
M
S
E
A
D
G
-
V
-
L
----
C
---------------
S
-
E
E
Y
------
E
------
D
E
Q
S
P
E
---------
K
I
I
E
L
Y
A
E
-
C
I
R
L
F
-----
H
S
I
D
I
-----
S
D
--
C
-----
P
Y
-----------
T
N
S
L
D
S
R
L
A
--------------
E
--
L
D
Y
------
L
---
L
--
N
N
D
--
L
--
A
--
D
V
D
----------
C
--
E
N
---------
W
EEDTPFKD
P
R
E
L
Y
D
--
F
L
--
K
-----
T
--
E
K
P
E
-
E
E
L
V
--------
F
S
-
H
G
D
L
G
D
S
N
I
F
V
--
K
D
----
G
------
K
V
S
G
F
I
D
L
G
-
R
-
S
G
-
R
A
D
K
W
Y
----
D
I
---
A
F
C
--
V
--
R
S
--------
I
---------------
R
--------------------
E
D
I
-
G
E
E
----------------------------------------------------
Q
Y
--
V
E
L
F
F
D
L
L
------------
G
---------
I
----
K
-----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-----------------------------------
31
Fugue
66.13
16%
-9
- C3 -
-
4OCV
2
?
A:
[24-378]
-------------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
-
G
------------
T
V
D
S
--
I
E
P
Y
G
--
D
--
G
H
-
I
N
T
T
Y
L
V
---
T
T
D
G
---------
P
R
Y
I
---
L
Q
R
-----
M
N
T
-----
G
-----
I
------
F
P
----
D
T
--
V
N
L
M
-
R
N
V
E
-------
L
-
V
---------
T
S
T
L
--
K
A
Q
--
G
-----
K
--
E
T
----------------------
L
D
-----
I
V
R
T
T
S
G
-
D
-
T
----
W
---------------
A
-
E
I
D
------
G
------
G
A
W
R
V
Y
---------
K
F
I
E
H
T
M
S
--
Y
N
L
V
-----
P
N
P
D
V
F
R
-
E
-
A
G
--
R
-----
A
F
-----------
G
D
F
Q
N
F
L
S
G
FDANQLTETIAHFH
D
--
T
P
H
------
R
---
F
--
E
D
F
--
K
--
K
--
A
L
A
A
DELGRAAGC
G
--
P
E
---------
I
---------
E
F
Y
L
S
--
H
A
--
D
-----
Q
--
Y
A
V
V
-
M
D
G
L
R
D
GSIPLR
V
T
-
H
N
D
T
K
L
N
N
I
L
M
DA
T
T
----
G
------
K
A
R
A
I
I
D
-
L
-
D
-
T
I
-
M
P
G
S
M
L
F
D
F
G
D
S
---
I
R
F
--
G
--
A
S
--------
T
---------------
A
--------------------
L
E
D
-
E
R
D
L
---------
D
K
V
H
F
S
T
E
L
F
R
----------
A
Y
T
E
---
G
F
V
G
E
L
---
R
D
S
I
T
A
R
--
E
A
E
L
L
P
F
S
------------
G
N
L
L
T
M
E
C
G
M
R
----
F
-----
L
A
D
Y
L
E
G
D
V
Y
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
56
SP3
64.37
15%
22
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
--------AK
M
R
-
I
S
P
E
L
K
K
L
I
---------------------
E
K
Y
--
R
C
V
K
D
TE
G
--
M
S
-
P
A
K
V
Y
K
L
V
G
E
N
------------
E
N
L
Y
---
L
K
M
-----
T
D
S
-----
R
-----
Y
KGTTYD
V
E
----
R
E
--
K
D
M
M
-
L
W
L
E
G
-
K
---
L
P
-
V
---------
P
K
V
L
H
F
E
R
H
--
D
-----
G
--
W
S
----------------------
N
L
-----
L
M
S
E
A
D
G
-
V
-
L
C
S
E
E
Y
---------------
E
-
D
E
Q
------
S
-------
P
E
K
I
I
---------
E
L
Y
A
E
C
I
R
-
L
F
H
S
I
-----
D
-------
I
-
S
D
--
C
-----
P
Y
-----------
T
N
S
L
D
S
R
L
A
--------------
E
--
L
D
Y
------
L
---
L
--
N
N
D
--
L
--
A
--
D
V
D
----------
C
--
E
N
WEEDTPFKD
P
---------
R
E
L
Y
D
--
F
L
--
K
-----
T
--
E
K
P
E
-
E
E
L
V
--------
F
S
-
H
G
D
L
G
D
S
N
I
F
V
--
K
D
----
G
------
K
V
S
G
F
I
D
L
G
-
R
-
S
G
-
R
A
D
K
W
Y
----
D
I
---
A
F
C
--
V
--
R
S
--------
I
---------------
R
--------------------
E
D
I
-
G
E
E
-------------
Q
Y
V
E
L
F
F
D
----------
L
L
G
I
---
K
P
-
D
W
E
---
K
I
K
Y
Y
I
L
--
L
D
E
L
F
---------------------------------------------------------------------------------------
55
SP3
64.35
15%
0
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MD
L
D
-
T
D
A
N
T
I
P
E
L
K
E
R
A
H
M
-
L
C
A
R
F
LGGAWKTV
P
L
E
H
L
R
I
S
R
I
K
--
G
--
G
M
-
S
N
M
L
F
L
C
---
R
L
S
EVYPPIRNEP
N
K
V
L
---
L
R
V
Y
FNPE
T
E
S
-----
H
-----
L
------
V
A
----
E
S
--
V
I
F
T
-
L
L
S
E
R
-
H
----
L
-
G
---------
P
K
L
Y
--
G
I
F
--
S
---------
G
----------------------
G
R
-----
L
E
E
Y
I
P
S
-
R
-
P
--------------------
L
-
S
C
H
------
E
------
I
S
L
--
A
---------
H
M
S
T
K
I
A
K
-
R
V
A
K
V
-----
H
Q
L
E
V
P
I
-
W
-
K
E
--
P
D
Y
L
C
E
A
L
-----------
Q
R
W
L
K
Q
L
T
G
--------------
T
--
V
D
A
E
H
R
F
D
L
P
---
E
--
E
C
G
--
V
--
S
--
S
V
N
----------
C
--
L
D
---------
L
---------
A
R
E
L
E
--
F
L
--
R
A
----
H
--
I
S
L
S
-
K
S
P
V
--------
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
K
----
R
------
L
V
--
L
I
D
F
E
-
Y
-
A
S
-
Y
N
Y
R
A
F
----
D
F
---
A
N
H
--
F
--
I
E
--------
W
T
IDYDIDEAPF
Y
K
I
Q
T
--------------------
E
N
F
P
E
N
D
Q
---------
M
L
E
F
F
L
N
Y
L
R
E
Q
GNTRENE
L
Y
K
K
S
E
---
D
L
V
Q
E
T
LPF
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
------------
L
---------
S
PVGF
G
-----
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA----------------------------
54
HHSearch
63.52
15%
-4
- C3 -
-
3C5I
3
?
D:
[15-293]
---------------
L
Y
I
K
K
I
C
L
E
K
V
P
E
-
W
NHFTE-------
D
N
L
R
--
V
K
Q
I
L
------
L
-
T
N
Q
L
F
E
V
G
L
K
E
E
T
A
N
N
Y
NSIR--
T
R
V
L
---
F
R
I
-----
Y
G
K
HVDEL
Y
-----
N
------
T
I
----
S
E
--
F
E
V
Y
-
K
T
M
S
K
-
Y
---
K
I
-
A
---------
P
Q
L
L
--
N
T
F
-----------
N
G
----------------------
G
R
-----
I
E
E
W
L
Y
G
-
D
-
P
----
L
---------------
R
-
I
D
D
------
L
------
K
N
P
T
I
L
---------
I
G
I
A
N
V
L
G
-
K
F
H
T
L
-----
S
R
K
R
H
L
P
-
E
H
W
D
RT
P
-----
C
I
-----------
F
K
M
M
E
K
W
K
N
--------------
Q
--
L
F
K
------
Y
---
K
NI
E
K
Y
--
N
--
C
--
D
I
H
----------
K
Y
I
K
E
---------
S
---------
D
K
F
I
K
--
F
M
--
K
V
Y
---
S
KS
D
N
L
A
-
N
T
I
V
--------
F
C
-
H
N
D
L
Q
E
N
N
I
I
N
--
T
N
----
K
-------
C
L
R
L
I
D
-
F
-
E
Y
S
G
-
F
N
F
L
A
T
----
D
I
---
A
N
F
--
F
--
I
E
--------
T
---------------
S
IDYSVSSYPF
F
E
I
D
KKKYIS
Y
E
N
-
R
K
L
F
---------
I
T
A
Y
L
S
N
Y
----------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
63.49
18%
16
- C3 -
-
3HAM
3
?
A:
[6-250]
------------------
A
E
I
Y
E
H
L
N
K
Q
-
I
------------
K
I
N
E
--
L
R
Y
L
S
--
S
--
G
D
-
D
S
D
T
F
L
C
---
N
------------
E
Q
Y
V
---
V
K
V
-----
P
K
R
D
S
V
R
-
I
-----
S
------
Q
K
----
R
E
--
F
E
L
Y
-
R
F
L
E
N
-
C
KL-
S
Y
-
Q
I--------
P
A
V
V
--
Y
Q
S
-----------
D
R
----------------------
F
N
-----
I
M
K
Y
I
K
G
-
E
-
R
----
I
---------------
T
-
Y
E
Q
Y
H
K
L--
S
E
K
----
E
K
D
A
L
A
---------
Y
D
E
A
T
F
L
K
-
E
L
H
S
I
-----
E
I
D
C
S
V
S
-
L
-
F
S
D-
A
-----
L
V
-----------
N
K
K
D
K
F
L
Q
D
-----------------
K
K
L
------
L
---
I
--
S
I
L
--
E
K
E
Q
--
L
L
T
----------
D
--
E
M
---------
L
---------
E
H
I
E
T
--
I
Y
--
E
N
I
L
N
N
A
--
V
L
F
K
-
Y
T
P
C
--------
L
V
-
H
N
D
F
S
A
N
N
M
I
F
--
R
N
----
N
------
R
L
F
G
V
I
D
-
F
-
G
D
F
N
-
V
G
D
P
D
N
----
D
F
---
L
C
L
--
L
--
D
C
--------
S
TDDF-----------
G
--------------------
K
E
F
-
G
R
K
V
---------
L
K
Y
Y
Q
H
K
A
----------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
62.12
14%
-14
- C3 -
-
5IQI
1
AACA_STAAU
C:
[13-257]
---------------
K
A
M
K
Y
L
I
E
H
Y
F
D
N
-
F
------------
K
V
D
S
--
I
E
I
I
G
--
S
--
G
Y
-
D
S
V
A
Y
L
V
---
N
------------
N
E
Y
I
---
F
K
T
-----
K
F
S
TNKK-
K
-----
G
------
F
A
----
K
E
--
K
A
I
Y
-
N
F
L
N
T
-
N
LET
N
V
-
K
I--------
P
N
I
E
--
Y
S
Y
I
S
D
-----
E
--
L
S
----------------------
I
L
-----
G
Y
K
E
I
K
G
-
T
-
F
----
L
---------------
T
-
P
E
I
------
Y
S
T
MS
E
E
E
Q
N
L
L
K
---------
R
D
I
A
S
F
L
R
-
Q
M
H
G
L
-----
D
Y
T
D
-
I
S
-
E
-
C
T
---------
I
-----------
D
N
K
Q
N
V
L
E
E
--------------
Y
--
I
L
-------
L
---
R
--
E
T
I
--
Y
--
N
--
D
L
T
----------
D
--
I
E
---------
K
---------
D
Y
I
E
S
--
F
M
--
E
R
L
N
A
-
T
--
T
V
F
E
-
G
K
K
C
--------
L
C
-
H
N
D
F
S
C
N
H
L
L
L
--
D
G
N---
N
------
R
L
T
G
I
I
D
-
F
-
G
D
S
G
-
I
I
D
E
Y
C
----
D
F
---
I
Y
L
--
L
--
E
D
--------
S
EEEI-----------
G
--------------------
T
N
F
-
G
E
D
I
---------
L
R
M
Y
G
N
------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
61.35
16%
24
- C3 -
-
3JR1
3
?
A:
[14-309]
------N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
-
Y
------------
F
I
K
H
--
K
E
K
L
Y
--
S
--
G
E
M
N
E
I
W
L
I
N
---
D
E
V
----------
Q
T
V
F
---
V
K
I
-----
N
E
R
-----
S
-----
Y
R
S
M
F
--
R
A
----
E
A
--
D
Q
L
A
-
L
L
A
K
T
-
N
---
S
I
-
N
---------
V
P
L
V
--
Y
G
I
--
G
-----
N
--
S
Q
----------------------
G
H
-----
S
F
L
L
L
E
---------
A
---------------
L
-
N
K
S
------
K
------
N
K
Q
S
S
F
---------
T
I
F
A
E
K
I
A
-
Q
L
H
Q
I
-----
Q
G
P
D
K
Y
G
-
L
-
D
F
--
D
-----
T
W
L
GP
I
Y
Q
P
N
D
W
Q
T
S
W
A
K
F
F
S
E
--------------
N
R-
I
G
W
------
Q
---
L
--
Q
I
C
--
K
--
E
K
G
L
I
F
----------
G
--
N
I
---------
D
---------
L
I
V
Q
I
--
V
A
--
D
-----
T
L
-
S
K
H
N
-
P
K
P
S
--------
I
L
-
H
G
N
L
W
I
E
N
C
I
Q
--
V
D
----
D
-------
K
I
F
V
C
N
-
P
-
A
-
C
Y
-
W
G
D
R
E
C
----
D
I
---
A
F
S
S
L
F
--
E
P
--------
F
---------------
P
--------------------
T
N
F
-
Y
Q
R
Y
---------
N
E
I
-------
Y
----------
P
L
E
E
---
G
Y
L
E
R
K
---
L
I
Y
Q
L
Y
Y
--
L
L
N
F
S
Y
R
Y
------------
Y
---------
N
----
K
-----
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
---------------------------------
25
Fugue
59.45
13%
26
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------SA
F
T
-
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
-
H
------------
G
I
R
V
--
D
S
G
L
T
--
P
L
N
S
Y
-
E
N
R
V
Y
Q
F
---
Q
D
EDR--------
R
R
F
V
---
V
K
F
Y
RPER
W
T
A
-----
D
-----
Q
------
I
L
----
E
E
--
H
Q
F
A
-
L
Q
L
V
N
-
D
---
E
V
-
P
VA
A
P
V
A
F
N-
G
Q
T
L
--
L
N
H
--
Q
-----
G
--
F
Y
----------------------
F
A
-----
V
F
P
S
V
G
G
-
R
-
Q
----
F
------------------
E
A
------
D
------
N
I
D
Q
M
E
---------
A
V
G
R
Y
L
G
R
-
M
H
Q
T
G
-----
R
K
Q
L
F
I
H
-
R
-
P
T
--
I
-----
G
L
-----------
N
E
Y
L
I
E
P
R
K
--------------
L
--
F
E
D
------
A
TLI
P
--
S
G
L
--
K
--
A
--
A
F
L
----------
K
--
A
T
---------
D
---------
E
L
I
A
A
--
V
T
--
A
-----
H
--
W
R
E
D
-
F
T
V
L
--------
R
L
-
H
G
D
C
H
A
G
N
I
L
W
--
R
D
----
G
--------
P
M
F
V
D
-
L
D
D
-
A
R
-
N
G
P
A
V
Q
----
D
L
WML
L
N
G
--
D
--
K
A
--------
E
---------------
Q
--------------------
R
M
Q
-
L
E
T
I
---------
I
E
A
Y
E
E
F
S
E
F
D
----------
T
A
E
I
---
G
L
I
E
P
L
---
R
A
M
R
L
V
Y
--
Y
L
A
W
L
M
R
R
------------
W
---------
A
----
D
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY---------------
47
HHSearch
59.32
14%
-16
- C3 -
-
5IQC
2
AACA_STAAU
A:
[13-257]
---------------
K
A
M
K
Y
L
I
E
H
Y
F
D
N
-
F
------------
K
V
D
S
--
I
E
I
I
G
--
S
--
G
Y
-
D
S
V
A
Y
L
V
---
N
------------
N
E
Y
I
---
F
K
T
-----
K
F
S
TNKK-
K
-----
G
------
Y
A
----
K
E
--
K
A
I
Y
-
N
F
L
N
T
-
N
LET
N
V
-
K
I--------
P
N
I
E
--
Y
S
Y
--
I
S
D---
E
--
L
S
----------------------
I
L
-----
G
Y
K
E
I
K
G
-
T
-
F
----
L
---------------
T
-
P
E
I
------
Y
S
T
MS
E
E
E
Q
N
L
L
K
---------
R
D
I
A
S
F
L
R
-
Q
M
H
G
L
-----
D
Y
T
D
-
I
S
-
E
-
C
T
---------
I
-----------
D
N
K
Q
N
V
L
E
E
-----------------
Y
I
L
------
L
---
R
--
E
T
I
--
Y
--
N
--
D
L
T
----------
D
--
I
E
---------
K
---------
D
Y
I
E
S
--
F
M
--
E
R
L
N
A
-
T
--
T
V
F
E
-
G
K
K
C
--------
L
C
-
H
N
D
F
S
C
N
H
L
L
L
--
D
G
N---
N
------
R
L
T
G
I
I
D
-
F
-
G
D
S
G
-
I
I
D
E
Y
C
----
D
F
---
I
Y
L
--
L
--
E
D
--------
S
EEEI-----------
G
--------------------
T
N
F
-
G
E
D
I
---------
L
R
M
Y
G
N
------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
59.17
11%
-18
- C- -
-
3N4U
-
?
A:
[7-256]
---------------
D
Q
V
E
K
A
I
E
Q
L
Y
P
D
-
F
------------
T
I
N
T
--
I
E
I
S
G
--
E
--
G
N
-
D
C
I
A
Y
E
I
---
N
------------
R
D
F
I
---
F
K
F
-----
P
K
H
S
R
G
S
-
T
-----
N
------
L
F
----
N
E
--
V
N
I
L
-
K
R
I
H
N
K
L
---
P
L
-
P
I--------
P
E
V
V
--
F
T
G
--
M
P
S
ETY
Q
--
M
S
----------------------
F
A
-----
G
F
T
K
I
K
G
-
V
-
P
----
L
---------------
T
-
P
L
L
------
L
N
N
LP
K
Q
S
Q
N
Q
A
A
---------
K
D
L
A
R
F
L
S
-
E
L
H
S
I
-----
N
I
S
G
-
F
K
-
S
-
N
---------
L
V
-----------
L
D
F
R
E
K
I
N
E
--------------
D
--
N
K
K
------
I
---
K
--
K
L
L
--
S
--
R
--
E
L
K
----------
G
--
P
Q
---------
M
---------
K
K
V
D
D
--
F
Y
--
R
D
I
L
E
N
E
--
I
Y
F
K
-
Y
Y
P
C
--------
L
I
-
H
N
D
F
S
S
D
H
I
L
F
--
D
T
EK--
N
------
T
I
C
G
I
I
D
-
F
-
G
D
A
A
-
I
S
D
P
D
N
----
D
F
---
I
S
L
--
M
--
E
D
DEE-----
Y
---------------
G
--------------------
M
E
F
-
V
S
K
I
---------
L
N
H
Y
K
H
K
D
----------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
58.69
13%
-4
- C3 -
-
5FUT
10
CHKA_HUMAN
A:
[9-308]
--------------
R
R
R
A
Y
L
W
C
K
E
F
L
P
G
A
W
RGLRE-------
D
E
F
H
--
I
S
V
I
R
--
G
--
G
L
-
S
N
M
L
F
Q
C
S
L
P
D
TTATLGDEP---
R
K
V
L
---
L
R
L
-----
Y
G
-G
A
---
E
-----
A
------
M
V
----
L
E
--
S
V
M
F
-
A
I
L
A
E
-
R
---
S
L
-
G
---------
P
K
L
Y
--
G
I
F
--
P
---------
Q
----------------------
G
R
-----
L
E
Q
F
I
P
S
-
R
-
R
----
L
---------------
D
-
T
E
E
------
L
------
S
L
P
D
I
S
---------
A
E
I
A
E
K
M
A
-
T
F
H
G
M
-----
K
M
P
F
N
-
K
-
E
-
P
K
--
W
-----
L
F
-----------
G
T
M
E
K
Y
L
K
E
--------------
V
--
L
R
I
------
K
---
F
--
T
E
E
S
R
I
--
K
--
K
L
H
----------
K
--
L
L
---------
S
---------
Y
N
L
P
L
--
E
L
--
E
N
L
R
S
-
L
L
-
E
S
T
P
-
S
P
V
V
--------
F
C
-
H
N
D
C
Q
E
G
N
I
L
L
--
L
E
----
G
RENSEK
Q
K
L
M
L
I
D
-
F
-
E
Y
S
S
-
Y
N
Y
R
G
F
----
D
I
---
G
N
H
--
F
--
C
E
--------
W
---------------
M
YDYSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
-
Q
L
H
F
---------
I
S
S
Y
L
P
A
F
Q
---------------------------------------------------------------------------------------------------------------------------------
24
Fugue
58.06
13%
-33
- C3 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-------T
L
P
A
V
-
I
S
R
W
L
S
S
V
L
P
G
G
A
A
P
-
E
------------
V
T
V
E
--
S
G
V
D
S
--
T
--
G
M
-
S
S
E
T
I
I
L
---
T
------------
A
R
W
Q
Q
DG
R
S
I
-----
Q
Q
K
-----
L
-----
V
------
A
R
----
V
A
P
A
A
E
D
V
-
P
V
F
P
T
-
Y
---
R
L
-
D
---------
H
Q
F
E
--
V
I
R
--
L
-----
V
--
G
E
LTDVPVPRVRWIETTGDVLG
T
P
F
F
-----
L
M
D
Y
V
E
G
-
V
-
V
----
P
PDVMPYTFGDNWFAD
A
-
P
A
E
------
R
------
Q
R
Q
L
Q
D
---------
A
T
V
A
A
L
A
T
-
L
H
S
I
P
-----
N
A
Q
N
T
F
S
F
L
-
T
D
--
T
-----
T
L
-----------
H
R
H
F
N
W
V
R
S
--------------
W
--
Y
D
F
------
A
---
V
--
E
G
I
--
G
--
R
--
S
P
L
----------
L
--
E
R
---------
T
---------
F
E
W
L
Q
--
S
H
--
W
-----
P
--
D
D
A
A
A
R
E
P
V
--------
L
L
-
W
G
D
A
R
V
G
N
V
L
Y
--
R
D
----
F
------
Q
P
V
A
V
L
D
W
E
-
M
-
V
A
-
L
G
P
R
E
L
----
D
V
---
A
W
M
--
I
F
A
H
R
--------
V
---------------
F
--------------------
Q
E
L
-
A
G
L
A
TLPGLPEVM
R
E
D
D
V
R
A
T
Y
Q
A
----------
L
T
G
V
E
L
G
D
L
H
W
F
Y
---
V
Y
S
G
V
M
W
--
A
C
V
F
M
R
T
G
------------
A
---------
R
----
R
-----
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH---------------------
48
HHSearch
50.92
18%
17
- C3 -
-
4R78
2
?
A:
[23-252]
---------------
K
I
I
K
E
K
I
S
S
L
L
S
Q
E
E
------------
E
V
L
S
--
V
E
Q
L
---
G
--
G
M
-
T
N
Q
N
Y
L
A
K
T
T
N
------------
K
Q
Y
I
---
V
K
F
-----
F
G
K
-----
G
TEKLI
N
------
R
Q
----
D
E
--
K
Y
N
L
-
E
L
L
K
D
-
L
---
G
L
-
D
V--------
K
N
Y
L
--
F
D
I
--------
E
--
A
G
----------------------
I
K
-----
V
N
E
Y
I
E
S
-
A
I
T
----
L
---------------
D
-
S
T
S
--------------
I
K
T
K
F
---------
D
K
I
A
P
I
L
Q
-
T
I
H
T
S
-----
A
K
E
L
R
-
G
-
E
-
F
---
A
-----
P
F
-----------
E
E
I
K
K
Y
-
E
S
--------------
L
--
I
E
E
------
Q
--------
I
--
P
--
Y
--
A
N
Y
----------
E
--
S
V
---------
R
---------
N
A
V
F
S
--
L
E
--
K
-----
R
L
-
A
D
L
G
-
V
D
R
K
--------
S
C
-
H
I
D
L
V
P
E
N
F
I
E
--
S
P
----
Q
------
G
R
L
Y
L
I
D
-
W
-
E
Y
S
S
-
M
N
D
P
M
W
----
D
L
---
A
A
L
--
F
--
L
E
--------
S
EF-------------
T
--------------------
S
Q
E
-
E
E
T
F
---------
L
S
H
Y
E
S
D
Q
----------------------------------------------------------------------------------------------------------------------------------