@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A6TIY6_KLEP7_: (2019-02-04 )
MKEPPLNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG
Atome Classification :
(25 SA)
--.........10........20.....-.-..30.-..---.---..---------.-.40--......---..---.50-.---.---.......60........70........80........90....-..--.-.--100-.--...--.....--110.--------......120......--.130--.........140....--..---.-150.....--..160.......170.....-..180.........190.......200---........210.......220...---....230.......240.......250.---......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MKEPPLNRT
N
I
F
FGESHS
D
W
LPVRGG-E-SG
D
F
V
-
F
R---R---GD---------G-
H
A
---
F
A
KIAP---AS---RR--G---E---LAGERD
R
L
I
W
L
KGRGVACPEVI
N
W
Q
E
EQEG
A
C
L
V
I
TAIPGVPA-AD--L-S--
G
---
A
--
D
L
L
--
K
A
W
P
S
--
M
G
Q
Q
--------
L
GAVHSLSVDQC
P
F
E
--
R
R
----
L
S
R
M
F
G
R
A
V
D
V
V
SRNA--VN---P-DFLPDEDK--ST
P
Q
L
D
L
L
A
R
V
E
R
ELPVRLD-QER--T
D
M
V
V
CHGDPCMPNFMVDPK
T
----
L
Q
C
T
G
L
I
DLGRLGT
A
D
R
Y
A
D
L
A
L
M
---
I
ANAEENWAA
P
D
E
A
E
R
A
F
A
V
L
F
N
V
LGIE---AP
D
R
E
R
L
A
F
Y
L
RLDPLTWG
1
PsiBlast_PDB
80.17
36%
3
- C- -
-
4H05
-
?
A:
[16-264]
--------------------
E
W
V
V
V
E
D
G
-
A
-
S
G
A
G
V
-
Y
R
L
--
R
---
G
G
---------
G
-
R
E
L
--
F
V
K
V
A
A
---
L
G
---
A
G
--
V
---
G
---
L
L
G
E
A
E
R
L
V
W
L
A
E
V
G
I
P
V
P
R
V
V
E
G
G
G
D
E
R
V
A
W
L
V
T
E
A
V
P
G
R
P
A
S
A
R
--
W
-
P
--
R
---
E
--
Q
R
L
--
D
V
A
V
A
--
L
A
G
L
--------
A
R
S
L
H
A
L
D
W
E
R
C
P
F
D
--
R
S
----
L
A
V
T
V
P
Q
A
A
R
A
V
A
E
G
S
--
V
D
---
L
-
E
D
L
D
E
E
R
K
--
G
W
S
G
E
R
L
L
A
E
L
E
R
T
R
P
A
D
--------
E
D
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
T
----
C
E
V
T
G
L
I
D
V
G
R
V
G
R
A
D
R
H
S
D
L
A
L
V
L
R
E
L
A
H
E
E
D
P
W
F
G
P
-
E
C
S
A
A
F
L
R
E
Y
G
R
G
W
D
G
---
A
V
S
E
E
K
L
A
F
Y
R
L
L
D
-----
21
Blastp_CBE
78.15
34%
-6
- C3 -
-
1ND4
1
KKA2_KLEPN
B:
[23-261]
--------------------
D
W
A
Q
Q
T
I
G
-
C
-
S
D
A
A
V
-
F
R
LSA
Q
---
G
R
---------
P
-
V
L
---
F
V
K
T
D
L
---
S
G
---
A
L
--
N
---
E
---
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
G
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
L
L
L
G
E
V
P
G
----
Q
D
--
L
-
L
--
S
---
S
--
H
L
A
--
P
A
E
K
V
SI
M
A
D
A
--------
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
--
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
D
---
Q
-
D
D
L
D
E
E
H
Q
--
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
------
D
G
--
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
R
----
F
--
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
---
T
R
D
I
A
E
E
L
G
G
-
E
W
A
D
R
-
F
L
V
L
Y
---
G
I
A
---
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
-----
2
PsiBlast_PDB
77.28
34%
-4
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[23-261]
--------------------
D
W
A
Q
Q
T
I
G
-
C
-
S
D
A
A
V
-
F
R
L
S
A
Q
---
G
R
---------
P
-
V
L
---
F
V
K
T
D
L
---
S
G
---
A
L
--
N
---
E
---
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
G
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
L
L
L
G
E
V
P
G
----
Q
D
--
L
-
L
--
S
---
S
--
H
L
A
--
P
A
E
K
V
S
I
M
A
D
A
--------
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
--
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
D
---
Q
-
D
D
L
D
E
E
H
Q
--
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
------
D
G
--
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
R
----
F
--
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
---
T
R
D
I
A
E
E
L
G
G
-
E
W
A
D
R
-
F
L
V
L
Y
---
G
I
A
---
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
-----
118
SP3
76.47
29%
-8
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---
G
S
P
A
A
W
V
E
R
L
F
----
G
Y
D
W
A
Q
Q
T
I
G
-
C
-
S
D
A
A
V
-
F
R
---
L
S
A
Q
G
R
---------
P
-
V
L
---
F
V
K
T
D
L
---
S
G
---
A
L
--
N
---
E
---
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
G
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
L
L
L
G
E
V
P
G
Q
D
L
-
L
S
--
S
-
H
--
L
---
A
---
P
A
--
E
K
V
S
I
--
M
A
D
A
--------
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
--
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
D
---
Q
-
D
D
L
D
E
E
H
Q
--
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
------
D
G
--
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
------
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
---
T
R
D
I
A
E
E
L
G
-----
G
E
W
A
D
R
F
L
V
L
Y
G
I
A
---
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
--
5
PsiBlast_PDB
76.38
29%
4
- C3 -
-
4FEU
2
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
8
PsiBlast_PDB
76.34
29%
-2
- C3 -
-
4GKI
3
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
83
HHSearch
75.06
30%
9
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[24-263]
--------------------
W
A
Q
Q
T
I
G
C
S
D
-
A
A
V
F
R
-
L
S
---
A
---
Q
G
---------
R
P
V
L
---
F
V
K
T
D
L
---
S
G
---
A
L
--
N
---
E
---
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
G
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
L
L
L
G
E
V
P
G
Q
D
L
-
L
S
--
S
-
H
------
L
--
A
P
A
--
E
K
V
S
I
--
M
A
D
A
--------
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
--
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
D
---
Q
-
D
D
L
D
E
E
H
Q
--
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
------
D
G
--
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
R
------
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
---
T
R
D
I
A
E
E
L
G
--
G
---
E
W
A
D
R
F
L
V
L
Y
G
I
A
---
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
---
3
PsiBlast_PDB
74.97
29%
6
- C3 -
-
4FEV
2
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
7
PsiBlast_PDB
74.95
29%
8
- C3 -
-
4GKH
2
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
9
PsiBlast_PDB
74.41
29%
5
- C3 -
-
4EJ7
2
?
A:
[55-289]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
6
PsiBlast_PDB
73.78
29%
10
- C3 -
-
4FEW
2
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
85
HHSearch
73.31
33%
6
- C3 -
-
4H05
-
?
B:
[22-266]
-------------------------
D
G
A
-
S
G
A
G
V
Y
R
-
L
R
---
G
---
G
G
---------
R
-
E
L
---
F
V
K
V
A
A
---
L
G
---
A
G
--
V
---
G
---
L
L
G
E
A
E
R
L
V
W
L
A
E
V
G
I
P
V
P
R
V
V
E
G
G
G
D
E
R
V
A
W
L
V
T
E
A
V
P
G
R
P
A
-
S
A
--
R
W
P
--
R
---
E
--
Q
R
L
--
D
V
A
V
A
--
L
A
G
L
--------
A
R
S
L
H
A
L
D
W
E
R
C
P
F
D
--
R
S
----
L
A
V
T
V
P
Q
A
A
R
A
V
A
E
G
S
--
V
D
---
L
-
E
D
L
D
E
E
------
R
K
G
W
S
G
E
R
L
L
A
E
L
E
R
T
R
P
--
A
D
--
E
D
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
T
----
C
E
V
T
G
L
I
D
V
G
R
V
G
R
A
D
R
H
S
D
L
A
L
V
---
L
R
E
L
A
H
E
E
D
-
P
W
F
G
P
E
C
S
A
A
F
L
R
E
Y
G
R
G
WD
G
A
V
S
E
E
K
L
A
F
Y
R
L
L
D
E
F
---
4
PsiBlast_PDB
72.75
29%
7
- C3 -
-
4FEX
3
?
A:
[35-269]
---------------------------
G
-
Q
-
S
G
A
T
I
-
Y
R
L
--
Y
---
G
K
---------
P
-
N
A
P
E
L
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-------------
L
--
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
D
---
A
-
S
D
F
D
D
E
R
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
F
S
--------
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
----
L
--
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
--
F
S
P
S
L
Q
K
R
----
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
-----
81
HHSearch
70.92
29%
-11
- C3 -
-
4GKI
1
?
C:
[39-271]
-------------------------------
A
T
I
Y
R
-
L
Y
---
G
---
K
P
NA-------
P
-
E
L
---
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
-
F
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-
L
--
E
E
Y
P
D
--
S
G
E
--
N
I
V
D
A
--
L
A
V
F
--------
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
V
D
A
--------
S
-
D
F
D
D
E
R
-
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
------
F
S
--
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
------
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
-
F
S
-----
P
S
L
Q
K
R
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
---
82
HHSearch
69.50
29%
-6
* C3 *
-
4GKH
2
?
A:
[39-271]
-------------------------------
A
T
I
Y
R
-
L
Y
---
G
---
K
P
N
A
-------
P
-
E
L
---
F
L
K
H
G
K
---
G
S
---
V
A
--
N
---
D
---
V
T
D
E
M
V
R
L
N
W
L
T
A
-
F
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
L
L
T
T
A
I
P
G
K
T
A
-
F
Q
--
V
-
L
--
E
E
Y
P
D
--
S
G
E
--
N
I
V
D
A
--
L
A
V
F
--------
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
--
S
D
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
V
D
A
--------
S
-
D
F
D
D
E
R
-
N
--
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
------
F
S
--
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
K
------
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
---
W
N
C
L
G
E
-
F
S
-----
P
S
L
Q
K
R
L
F
Q
K
Y
G
I
D
---
N
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
---
84
HHSearch
69.23
33%
2
- C- -
-
4H05
-
?
A:
[22-266]
-------------------------
D
G
A
-
S
G
A
G
V
Y
R
-
L
R
---
G
---
G
G
---------
R
-
E
L
---
F
V
K
V
A
A
---
L
G
---
A
G
--
V
---
G
---
L
L
G
E
A
E
R
L
V
W
L
A
E
V
G
I
P
V
P
R
V
V
E
G
G
G
D
E
R
V
A
W
L
V
T
E
A
V
P
G
R
P
A
-
S
A
--
R
W
P
--
R
---
E
--
Q
R
L
--
D
V
A
V
A
--
L
A
G
L
--------
A
R
S
L
H
A
L
D
W
E
R
C
P
F
D
--
R
S
----
L
A
V
T
V
P
Q
A
A
R
A
V
A
E
G
S
--
V
D
---
L
-
E
D
L
D
E
E
------
R
K
G
W
S
G
E
R
L
L
A
E
L
E
R
T
R
P
--
A
D
--
E
D
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
T
----
C
E
V
T
G
L
I
D
V
G
R
V
G
R
A
D
R
H
S
D
L
A
L
V
---
L
R
E
L
A
H
E
E
D
-
P
W
F
G
P
E
C
S
A
A
F
L
R
E
Y
G
R
G
WD
G
A
V
S
E
E
K
L
A
F
Y
R
L
L
D
E
F
---
90
HHSearch
64.09
21%
21
- C3 -
-
1L8T
2
KKA3_ENTFL
A:
[19-262]
---------------------
V
K
D
T
E
G
M
-
S
P
A
K
V
Y
K
-
L
V
---
G
---
E
N
---------
E
-
N
L
---
Y
L
K
M
T
D
---
S
R
YKG
T
T
--
Y
---
D
---
V
E
R
E
K
D
M
M
L
W
L
E
G
-
K
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
--
E
-
Y
E
D
E
---
Q
--
S
P
E
--
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
D
VDC
E
-
N
W
E
E
D
-------
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
---
P
E
--
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
K
------
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
----
E
E
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
---
119
SP3
62.81
20%
35
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
AK
M
R
I
S
P
E
L
K
K
L
I
E
----
K
Y
R
C
V
K
D
T
E
G
-
M
-
S
P
A
K
V
-
Y
K
---
L
V
G
-
E
N
---------
E
-
N
L
---
Y
L
K
M
T
D
SRY
K
G
---
T
T
--
Y
---
D
---
V
E
R
E
K
D
M
M
L
W
L
E
G
-
K
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
--
E
-
Y
--
E
---
D
EQ
S
P
E
--
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
AD
V
D
---
C
-
E
N
W
E
E
D
T
P
--
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
P
-------
E
--
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
------
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
E
E
----
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--
10
PsiBlast_PDB
62.70
25%
5
- C3 -
-
2BKK
1
KKA3_ENTFL
A:
[42-263]
----------------------------------------------------------------
Y
L
K
M
T
D
---
S
R
---
Y
K
--
G
TTY
D
---
V
E
R
E
K
D
M
M
L
W
L
E
G
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
--
E
-
Y
--
E
---
D
--
E
Q
S
P
E
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
-
L
D
Y
L
L
N
N
-----------------------------
K
D
P
R
E
L
Y
D
F
L
K
-
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
--
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
----
E
E
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
---
13
PsiBlast_PDB
62.54
25%
17
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[39-262]
-----------------------------------------------------------
N
L
---
Y
L
K
M
T
D
---
S
R
---
Y
K
--
G
TTY
D
---
V
E
R
E
K
D
M
M
L
W
L
E
G
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
--
E
-
Y
--
E
---
D
--
E
Q
S
P
E
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
-
L
D
Y
L
L
N
N
D
-----------
L
A
D
V
D
C
--
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
-
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
--
K
D
----
G
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
----
E
E
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
---
103
Fugue
62.44
20%
26
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
-
M
-
S
P
A
K
V
-
Y
K
---
L
V
G
-
E
N
---------
E
-
N
L
---
Y
L
K
M
T
D
---
S
R
---
Y
K
--
G
---
T
TYD
V
E
R
E
K
D
M
M
L
W
L
E
G
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
E
Y
E
-
D
--
E
---
Q
--
S
P
E
--
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
D
---
V
-
D
--
C
E
N
W
E
--
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
P
-
E
E
----
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
------
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
E
E
Q
Y
V
E
L
F
F
D
L
L
G
I
--------
K
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--
89
HHSearch
62.44
21%
22
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[19-262]
---------------------
V
K
D
T
E
G
M
-
S
P
A
K
V
Y
K
-
L
V
---
G
---
E
N
---------
E
-
N
L
---
Y
L
K
M
T
D
---
S
R
YKG
T
T
--
Y
---
D
---
V
E
R
E
K
D
M
M
L
W
L
E
G
-
K
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
L
L
M
S
E
A
D
G
V
L
C
-
S
E
--
E
-
Y
ED
E
---
Q
--
S
P
E
--
K
I
I
E
L
--
Y
A
E
C
--------
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
--
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
D
VDC
E
-
N
W
E
E
D
-------
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
---
P
E
--
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
K
------
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
---
V
R
S
I
R
E
D
I
G
----
E
E
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
---
102
HHSearch
43.09
20%
-12
- C3 -
-
3CSV
8
?
A:
[16-232]
--------------
H
G
Y
A
D
W
N
R
T
P
---------
R
Y
Q
R
L
R
---
S
---
P
T
G--------
A
-
K
A
---
V
L
M
D
W
S
---
P
E
---
E
G
--
G
---
D
---
T
Q
P
F
V
D
L
A
Q
Y
L
R
N
L
D
I
S
A
P
E
I
Y
A
E
E
H
--
A
R
G
L
L
L
I
E
D
L
G
D
A
L
F
-
T
E
--
V
-
I
--
N
N
DP
A
--
Q
E
M
--
P
L
Y
R
A
--
A
V
D
L
--------
L
I
H
L
H
D
A
Q
T
P
E
L
A
R
L
D
P
E
T
----
L
S
E
M
T
R
L
A
F
S
E
Y
R
Y
-----------
A
I
L
G
D
A
-------
A
E
D
N
R
K
R
F
E
H
R
F
A
Q
I
L
S
A
Q
L
E
--
G
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
E
R
EG--
L
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
---
L
Q
D
A
R
---------------------------------------------
98
HHSearch
39.15
16%
-10
- C3 -
-
5FTG
9
CHKA_HUMAN
A:
[30-272]
-----------------
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
M
L
F
Q
-
C
S
---
L
---
P
D
TTATLGDEP
R
-
K
V
---
L
L
R
L
Y
G
------------
E
---
A
---
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
F
P
Q
----
G
R
L
E
Q
F
I
P
S
R
R
L
-
D
T
--
E
-
E
------
L
--
S
L
P
--
D
I
S
A
E
--
I
A
E
K
--------
M
A
T
F
H
G
M
K
M
P
F
N
K
E
P
--
K
W
----
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
K
--
F
T
---
E
E
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
L
E
-----
S
T
P
--
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
R
ENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
---
F
C
E
W
M
---------------------------------------------
97
HHSearch
37.26
16%
-1
- C3 -
-
5FUT
7
CHKA_HUMAN
A:
[30-272]
-----------------
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
M
L
F
Q
-
C
S
---
L
---
P
D
TTATLGDEP
R
-
K
V
---
L
L
R
L
Y
G
----------G
A
E
---
A
---
M
V
L
E
S
V
M
F
A
I
L
A
E
R
S
L
G
-
P
K
L
Y
G
I
F
P
Q
----
G
R
L
E
Q
F
I
P
S
R
R
L
-
D
T
--
E
-
E
------
L
--
S
L
P
--
D
I
S
A
E
--
I
A
E
K
--------
M
A
T
F
H
G
M
K
M
P
F
N
K
E
P
--
K
W
----
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
K
--
F
T
---
E
E
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
N
L
R
S
L
L
E
-----
S
T
P
--
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
R
ENSE
K
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
---
F
C
E
W
M
---------------------------------------------