@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K4ZQI4_PAEA2: (2019-01-30 )
MKNKLYEHDITAIAWQDKHELLERILQQAGTIAITPLMQGMEAEAVKVATDADRYVLKIWSRDSKPDIRLQYQVMNMLHERGISVSKPIGWGINASGHSVLLTTFDGDPLRDGNAHTMREIANLLDHIHRISPEEIDRHTRLPRYNFRDYFFPGMHEYPDLYPLLEQLVELASPTHKRIIHGDFHLGNIVEQQGRLTVIDWTNVQLGDPRYDFAWSLTLQQFYIPEHFAEVFRDTYVAMNEIQREELEVFQALACLRWMLLYRNGGVPMGADTLERVRRLLTSNPHLHGVTI
Atome Classification :
(20 SA)
--------------------.........10..--.-.....20......-----..30----.........40-.-...-..-..---50-.-.---------.....------.-60-..---.---.--.-..-.70......--..80.---.-----.....---..90.-----.-----------.------..--...100.--------------.....-.110--.---.------.---------.---------.....120----------.-.......--------130---------------------.-------------.---------.---------..---------.---.----------140-------.-----...----------.-..---.-----150---...-----.-------.---.----.-------.---.160..-----------.----...---.----170------..-----.--...--..---------.180.......190.-.--.-----.-.-.-..-200.......210...-..-.-----------------.220.------------.-.----...------------.230-......--.240.------------..-----------..-..-250-.....------..260------.-------...---....----270.......280.......290-------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------MKNKLYEHDI
T
A
I
--
A
-WQ
D
K
H
E
L
L
E
R
I
L
Q
-----QAG-----
T
I
A
I
T
P
L
MQGM-E-A
E
A
-
V
K
-VA---TD-A-
D
---------
R
Y
V
L
K
------
I
-WS-RD---S---K--P-
D
I
-
R
L
Q
Y
Q
V
M
N
M
--
L
H
E-R---G-----ISVSK---PI
G
W
G
-----I-----------N------AS--G
H
S
V
L
L
T
--------------TFDGD-PL----R---D------G---------
N
---------
A
H
T
M
R
E
I
-----------
A
-
N
L
L
D
H
I
H--------RI
S
---------------------
P
-------------
E
---------
E
---------
I
D
---------
R
---H----------T-R-------L-----PRY----------N-
F
R
---D-----Y-----FFP-----
G
-------
M
---H----E-------Y---P
D
L
Y
P
L
-----------
L
----
E
Q
L
---
V
----
E
--------LA-----S--PTH--
K
R
---------
I
I
HGDF
H
L
G
N
I
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-
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Q-Q--G-----
R
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L
-
T
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D
WTN
V
Q
LGDPR
Y
D
F
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W
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-----------------
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Q
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FY------------
I
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Q
------------
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A
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A
C
L
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------
W
M
L
-
L
------Y-------RNG---GVPM----
G
A
D
T
L
E
R
V
R
R
L
LTSNPHLHGVTI-------------
37
HHSearch
74.65
18%
-23
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[8-277]
----------------------------------------
T
E
D
E
L
R
N
F
L
T
-----
Q
Y
D
VGS--
L
T
S
Y
K
G
I
A
E
-----
N
S
N
-
F
L
-
L
H
---
T
T
-
K
-
D
---------
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I
L
T
------
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Y
E
-
K
--------
K
--
N
-
D
L
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--------------
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A
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M
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S
---------------------
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-------------
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L
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V
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---------
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-----
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V
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------------
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L
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--
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------------
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P
L
-
L
S
R
G
S
------
A
L
R
-
F
------
F
---------------------------------------------------------
7
PsiBlast_PDB
72.54
22%
15
- C2 -
-
4R7B
-
?
A:
[27-273]
------------------------------------------
E
K
I
S
S
L
L
S
-----
Q
E
E
-----
E
V
L
S
V
E
Q
L
G
G
M
-
T
-
N
Q
N
-
Y
L
-
A
K
---
T
T
-
N
-
K
---------
Q
Y
I
V
K
------
F
-
F
G
-
K
G
---
T
---
E
--
K
-
L
I
-
N
R
Q
D
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K
Y
N
L
E
L
L
K
D
-
L
---
G
-----
L
D
V
K
N
YLF
D
I
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A
G
-----
I
-----------
K
------
V
N
--
E
Y
I
E
S
A
I
--------------
T
L
D
S
T
-
S
I
----
K
-------------------------------
T
K
F
D
K
I
-----------
A
-
P
I
L
Q
T
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T
SAKELRG
E
F
A
---------------------
P
F
------------
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---------
E
---------
I
K
---------
K
---
Y
----------
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-
S
-------
L
IEEQI
P
Y
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----------
N
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Y
E
---
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-----
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--------------------------------------
R
---
N
A
V
F
S
L
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----
K
R
L
---
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----
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--------
L
G
---------
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D
--
R
K
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C
H
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D
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-----
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L
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M
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D
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A
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F
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L
-----------------
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S
E
F
T
------------
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-
Q
----
E
E
--------------
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T
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L
S
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Y
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S
D-
Q
T
P
V
S
------------
H
E
-----------
K
I
-
A
I
-
Y
K
I
-
L
Q
D
T
I
------
W
S
L
------------------------------------------------------------------
72
Fugue
70.62
15%
-26
- C2 -
-
3JR1
3
?
A:
[14-309]
----------------------------
N
L
Y
F
Q
--
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
-----
A
Y
Y
-----
F
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K
H
K
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K
L
Y
S
G
-
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M
N
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I
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I
N
---
D
E
-
V
-
Q
---------
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V
F
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K
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-
R
S
---
Y
---
R
--
S
M
F
R
-
A
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A
L
L
--
A
K
T
-
N
---
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-----
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N
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---
V
Y
G
I
G
-----
N
-----------
S
------
Q
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--
H
S
F
L
L
L
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--------------
A
L
----
N
K
----
S
---
K
------
N
---------
K
---------
Q
S
S
F
T
I
F
-----------
A
-
E
K
I
A
Q
L
H
--------
Q
I
Q
---------------------
G
-------------
P
---------
D
KYGLD
F
D
T
W
L
G
---------
P
---
I
----------
Y
-
Q
-------
P
-----
N
D
W
QT--------
S
-
W
A
---
K
-----
F
-----
F
S
E
NR
I
G
W
Q
-------
L
---
Q
----
I
-------
C
---
K
E
K
G
L
I
-----------
F
----
G
N
I
---
D
----
L
--------
I
V
-----
Q
--
I
V
A
--
D
T
L
S
KHNPKPS
I
L
H
G
N
L
W
I
E
N
C
I
-
Q
V
-
D
--
D
-----
K
-
I
-
F
-
V
C
-
N
-
P
A
C
Y
W
G
D
R
E
C
D
I
A
F
-
S
S
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L
-----------------
F
E
P
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---------------
P
----
T
N
F
------------
Y
Q
R
Y
-
N
E
I
Y
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P
--
L
E
E
G
Y
------------
L
E
-----------
R
K
-
L
I
-
Y
Q
L
-
Y
Y
L
L
N
------
F
S
Y
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R
------
Y
-------
Y
N
K
---
K
Q
S
Y
----
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
----------------------
6
PsiBlast_PDB
69.69
22%
23
- C2 -
-
4R78
2
?
A:
[27-273]
------------------------------------------
E
K
I
S
S
L
L
S
-----
Q
E
E
-----
E
V
L
S
V
E
Q
L
G
G
M
-
T
-
N
Q
N
-
Y
L
-
A
K
---
T
T
-
N
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K
---------
Q
Y
I
V
K
------
F
-
F
G
-
K
G
---
T
---
E
--
K
-
L
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
---
G
-----
L
D
V
K
N
YLF
D
I
E
A
G
-----
I
-----------
K
------
V
N
--
E
Y
I
E
S
A
I
--------------
T
L
D
S
T
-
S
I
----
K
-------------------------------
T
K
F
D
K
I
-----------
A
-
P
I
L
Q
T
I
H
T
SAKELR
G
E
F
A
---------------------
P
F
------------
E
---------
E
---------
I
K
---------
K
---
Y
----------
E
-
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-------
L
IEEQI
P
Y
A
----------
N
-
Y
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---
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--------------------------------------
R
---
N
A
V
F
S
L
-----------
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----
K
R
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---
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----
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--------
L
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--
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I
D
L
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P
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N
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P
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--
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R
-
L
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Y
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W
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Y
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S
M
N
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M
W
D
L
A
A
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F
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-----------------
E
S
E
F
T
------------
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-
Q
----
E
E
--------------
E
T
F
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L
S
H
Y
E
S
D-
Q
T
P
V
S
------------
H
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-----------
K
I
-
A
I
-
Y
K
I
-
L
Q
D
T
I
------
W
S
L
------------------------------------------------------------------
67
Fugue
66.65
14%
-0
- C2 -
-
3HAM
3
?
A:
[1-299]
--------------------
M
V
N
L
D
----------------
A
E
I
Y
E
H
L
N
K
-----
Q
I
K
-----
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V
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K
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------
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R
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M
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--------------
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---------
Q
Y
H
K
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K
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L
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G
V
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N
V
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C
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L
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C
S
T
D
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------------
F
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G
----
K
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F
------------
G
R
K
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K
Y
Y
----
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A
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L
L
Q
T
Q
A
E
M
F
I
F
--------------
35
HHSearch
66.56
18%
2
- C2 -
-
3CSV
9
?
A:
[4-277]
---------------------------------------
S
R
E
D
E
I
R
D
F
L
A
-----
T
H
G
YA---
D
W
N
R
T
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----------
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L
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---
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G
A
---------
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------
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---
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--
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---
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A
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--------------
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------
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L
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--------
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---------
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P
----------
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A
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A
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---------
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F
H
A
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L
L
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L
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R
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G
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I
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D
F
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D
A
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L
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L
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-----------------
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------------
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------------
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E
S
-----------
H
F
R
S
A
-
Y
A
V
-
I
A
V
Q
R
------
N
M
R
-
I
------
L
-------
G
I
F
-----------------------------------------------
76
Fugue
66.07
17%
18
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---------------------------------------
A
K
M
R
I
S
P
E
L
K
K
-----
L
I
E
-----
K
Y
R
C
V
K
D
T
E
G
M
S
P
-
A
K
V
-
Y
K
-
L
V
---
G
E
-
N
-
E
---------
N
L
Y
L
K
------
M
-
T
D
-
S
R
YKG
T
---
T
--
Y
-
D
V
-
E
R
E
K
D
M
M
L
W
--
L
E
G
-
K
---------
L
P
V
P
K
---
V
L
H
F
E
-----
R
-----------
H
------
D
G
--
W
S
N
L
L
M
S
--------------
E
A
D
G
V
-
L
C
----
S
---
E
E
Y
EDEQ
S
---------
P
---------
E
K
I
I
E
L
Y
-----------
A
-
E
C
I
R
L
F
H
--------
S
I
D
---------------------
I
SDCPYTNS
L
D
S
R
L
A
---------
E
---------
L
D
---------
Y
---
L
----------
L
-
N
-------
N
-----
D
L
A
----------
D
-
V
D
---
C
-----
E
-----
N
W
E
-----
E
-------
D
---
T
----
P
-------
F
---
K
D
P
R
E
L
-----------
Y
----
D
F
L
---
K
----
T
--------
E
K
-----
P
--
E
E
E
--
L
V
---------
F
S
H
G
D
L
G
D
S
N
I
F
-
V
K
-
D
--
G
-----
K
-
V
-
S
-
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
-
C
V
R
S
-----------------
I
R
E
D
I
------------
G
-
E
----
E
Q
Y
------------
V
E
L
F
-
F
D
L
L
----
G
I
K
P
D
------------
W
E
-----------
K
I
-
K
Y
-
Y
I
L
-
L
D
E
L
F
---------------------------------------------------------------------------
58
SP3
65.81
14%
-17
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
------------G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
T
I
P
E
L
--
K
-
E
R
A
H
M
L
C
A
R
F
L
G
G
AWKTV
P
L
E
-----
H
L
R
I
S
R
I
K
G
G
M
-
S
-
N
M
L
-
F
L
-
C
R
---
L
S
-
E
-
V
YPPIRNEPN
K
V
L
L
R
------
V
-
Y
F
N
P
E
---
T
---
E
--
S
-
H
L
-
V
A
E
S
V
I
F
T
L
--
L
S
E
-
R
---
H
-----
L
-
G
P
K
---
L
Y
G
I
F
-----
S
-----------
G
------------
G
R
L
E
E
--------------
Y
I
P
S
R
-
P
L
----
S
C
H
E
I
------
S
---------
L
---------
A
H
M
S
T
K
I
-----------
A
-
K
R
V
A
K
V
H
--------
Q
L
E
VPIWKEPD
Y
L
C
E
A
L
Q
R
W
L
K
Q
L
T
-------------
G
---------
T
---------
V
D
---------
A
---
E
----------
H
-
R
-------
F
-----
D
L
P
----------
E
-
E
C
---
G
-----
V
-----
S
S
V
-----
N
-------
C
---
L
----
D
-------
L
---
A
R
E
L
E
F
-----------
L
----
R
A
H
---
I
----
S
---------
L
-----
S
--
K
S
P
--
V
T
---------
F
C
H
N
D
L
Q
E
G
N
I
L
-
L
P
-
K
--
R
-------
L
-
V
-
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
-
I
E
W
T
IDYDIDEAPF
Y
K
I
-
Q
T
E
N
F
------------
P
-
E
----
N
D
Q
------------
M
L
E
F
-
F
L
N
Y
L
R
--
E
Q
G
N
T
RENE
L
Y
K
K
S
E
D
L
V
Q
-----------
E
T
-
L
P
-
F
V
P
-
V
S
H
F
F
------
W
G
V
-
W
G
L
----
L
-------
Q
V
E
---
L
S
P
V
GFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
--------------
53
HHSearch
64.99
16%
23
- C2 -
-
5IQI
1
AACA_STAAU
C:
[11-282]
----------------------------------------
N
V
K
A
M
K
Y
L
I
E
-----
H
Y
F
DNFK-
V
D
S
I
E
I
I
G
S
G
Y
-
D
-
S
V
A
-
Y
L
-
V
N
--------
N
---------
E
Y
I
F
K
------
T
-
K
F
-
S
T
---
N
K--
K
--
K
-
G
F
-
A
K
E
K
A
I
Y
N
F
--
L
N
T
-
N
LET
N
-----
V
K
I
P
N
---
I
E
Y
S
Y
-----
I
-----------
S
------
D
E
--
L
S
I
L
G
Y
K
--------------
E
I
K
G
T
-
F
L
----
T
---
P
------
E
I
Y
S
T
MS
E
E
E
Q
---------
N
L
L
K
R
D
I
-----------
A
-
S
F
L
R
Q
M
H
--------
G
L
D
---------------------
Y
-------------
T
---------
D
---------
I
S
---------
E
C--
T
I---------
D
N
K
-------
Q
-----
N
V
L
E
---------
E
-
Y
I
L
L
R
E
-----
T
-----
I
Y
N
-----
D
-------
L
---
T
----------------
D
I
E
K
D
Y
-----------
I
----
E
S
F
---
M
----
E
--------
R
L
N
A
TTV
F
--
E
G
K
--
K
C
---------
L
C
H
N
D
F
S
C
N
H
L
L
-
L
D
-
G
N-
N
-----
R
-
L
T
G
-
I
I
-
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
-
L
L
-
E
-----------------
D
S
E
E
E
------------
I
-
G
----
T
N
F
------------
G
E
D
I
-
L
R
M
Y
G
N
--
I
--
D
I
------------
E
K
-----------
A
K
-
E
Y
-
Q
D
I
-
V
E
E
Y
Y
------
P
I
E
-
T
------
I
-------
V
Y
G
-----------------------------------------------
39
HHSearch
64.65
16%
5
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[12-280]
----------------------------------------
H
P
D
T
I
M
D
A
L
F
-----
E
H
G
IRV--
D
S
G
L
T
P
L
-
N
S
Y
-
E
-
N
R
V
-
Y
Q
-
F
Q
---
D
E
D
R
-
R
---------
R
F
V
V
K
------
F
-
Y
R
-
P
E
---
R
WT-
A
--
D
-
Q
I
-
L
E
E
H
Q
F
A
L
Q
--
L
V
N
-
D
---
E
-----
V
P
V
A
A
---
P
V
A
F
N
-----
G
QT
L
L
N
------
H
------
Q
G
--
F
Y
F
A
V
F
P
--------------
S
V
G
G
R
-
Q
F
----
E
---
A
------
D
---------
N
---------
I
D
Q
M
E
A
V
-----------
G
-
R
Y
L
G
R
M
H
--------
Q
T
G
---------------------
R
-------------
K
---------
Q
---------
L
F
---------
I
HR-
P
T---------
I
-
G
-------
L
-----
N
E
Y
L---------
I
-
E
P
---
R
-----
K
-----
L
F
E
-----
D
-------
A
TLI
P
----
S
GL-----
K
---
A
A
F
L
K
A
-----------
T
----
D
E
L
---
I
----
A
--------
A
V
T
A
H
WR
E
--
D
F
T
--
V
L
---------
R
L
H
G
D
C
H
A
G
N
I
L
-
W
R
-
D
--------
G
-
P
-
M
-
F
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-
N
-----------------
G
D
K
-
A
------------
E
-
Q
----
R
M
Q
------------
L
E
T
I
-
I
E
A
Y
E
E
--
F
S
E
F
D
------------
T
A
-----------
E
I
-
G
L
-
I
E
P
-
L
R
A
M
R
------
L
V
Y
-
Y
------
L
-------
A
W
------------------------------------------------
68
Fugue
64.50
15%
-5
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-------------------------
S
A
F
T
F
Q
T
L
-------
H
P
D
T
I
M
D
A
L
F
-----
E
H
G
-----
I
R
V
D
S
G
L
T
P
L
N
-
S
-
Y
E
N
-
R
V
-
Y
Q
F
Q
D
E
D
-
R
-
R
---------
R
F
V
V
K
------
F
-
Y
R
-
P
E
RW-
T
---
A
--
D
-
Q
I
-
L
E
E
H
Q
F
A
L
Q
--
L
V
N
-
D
---
E
-----
V
P
V
A
A
---
P
V
A
F
N
GQT
L
L
N
-----------
H
------
Q
G
--
F
Y
F
A
V
F
P
--------------
S
V
G
G
R
-
Q
F
----
E
---
A
------
D
---------
N
---------
I
D
Q
M
E
A
V
-----------
G
-
R
Y
L
G
R
M
H
--------
Q
T
G
---------------------
R
-------------
K
QLFIHRPTI
G
---------
L
N
---------
E
---
Y
----------
L
-
I
-------
E
-----
P
R
K
----------
L
-
F
E
---
D
-----
A
-----
T
L
I
-----
P
-------
S
---
G
----
L
-------
K
---
A
A
F
L
K
A
-----------
T
----
D
E
L
---
I
----
A
--------
A
V
-----
T
--
A
H
W
--
R
E
D
F
T
V
L
----
R
L
H
G
D
C
H
A
G
N
I
L
-
W
R
----
D
-----
G
-
P
-
M
-
F
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-
N
------------------
G
D
K
A
------------
E
-
Q
----
R
M
Q
------------
L
E
T
I
-
I
E
A
Y
E
E
--
F
S
E
F
D
------------
T
A
-----------
E
I
-
G
L
-
I
E
P
-
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
------
W
-------
A
D
P
---
A
F
P
K
----
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY
78
Fugue
61.89
14%
-7
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
GG
A
-
W
K
T
V
P
L
E
H
L
R
I
S
R
-----
I
K
G
-----
G
M
S
N
M
L
F
L
C
R
L
-
S
-
E
V
Y
-
P
P
-
I
R
---
N
E
-
P
-
N
---------
K
V
L
L
R
------
V
Y
F
N
-
P
E
---
T
---
E
--
S
-
H
L
-
V
A
E
S
V
I
F
T
L
--
L
S
E
-
R
---
H
-----
L
G
-
P
K
---
L
Y
G
I
F
-----
S
-----------
G
G
R
L
E
E
Y
I
P
--
S
R
P
L
S
C
H
--------------
E
I
S
L
A
-
H
M
----
S
---
T
------
K
---------
I
---------
A
K
R
V
A
K
V
H
Q
LEVPIWKEP
D
-
Y
L
C
E
A
L
Q
--------
R
W
L
---------------------
K
-------------
Q
---------
L
---------
T
G
---------
T
---
V
----------
D
-
A
-------
E
-----
H
R
F
----------
D
-
L
P
---
E
-----
E
-----
C
G
V
-----
S
-------
S
---
V
----
N
-------
C
---
L
D
L
A
R
E
-----------
L
----
E
F
L
---
R
----
A
--------
H
I
-----
S
--
L
S
K
SP
V
T
---------
F
C
H
N
D
L
Q
E
G
N
I
L
-
L
P
-
K
--------
R
-
L
-
V
-
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
-
I
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
E
N
F
P
------------
E
-
N
----
D
Q
M
------------
L
E
F
F
-
L
N
Y
L
R
E
--
Q
G
N
T
R
------------
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
-
L
P
-
F
V
P
-
V
S
H
F
F
------
W
G
V
-
W
G
L
L
Q
V
E
L
-------
S
P
V
---
G
F
G
F
----
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
--------------
45
HHSearch
61.60
16%
15
- C2 -
-
3JR1
3
?
A:
[16-288]
-----------------------------------
Y
-
F
Q
G
M
W
K
S
I
S
Q
V
L
A
-----
E
Q
F
G
A
Y
Y
F
I
K
H
K
E
K
L
Y
S
G
E
-
M
-
N
E
I
-
W
L
-
I
N
---
D
E
-
V
-
Q
---------
T
V
F
V
K
------
I
-
N
E
-
R
S
---
Y
---
R
--
S
-
M
F
-
R
A
E
A
D
Q
L
A
L
--
L
A
K
T
N
---
S
-----
I
N
V
P
L
---
V
Y
G
I
G
-----
N
-----------
S
------
Q
G
--
H
S
F
L
L
L
E
--------------
A
L
N
K
S
-
K
N
-------------------------
K
---------
Q
S
S
F
T
I
F
-----------
A
-
E
K
I
A
Q
L
H
--------
Q
I
Q
---------------------
G
-------------
P
D--------
K
---------
Y
G
---------
L
D
F
-
D
T
W
L
GP
I
Y
Q
P
N
D
-
W
-------
Q
-----
T
S
W
A
---------
K
-
F
F
---
S
ENR
I
G
W
-----
Q
L
Q
-----
I
-------
C
---
K
----
E
-------
K
GLI
F
G
N
I
D
L
-----------
I
V
---
Q
I
V
---
A
----
D
--------
T
L
-----
S
KH
N
P
K
--
P
S
---------
I
L
H
G
N
L
W
I
E
N
C
I
-
Q
V
-
D
--
D
-----
K
-
I
-
F
-
V
C
-
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
-
S
S
-
L
---------------------
F
------------
E
-------
P
F
------------
P
T
N
F
-
Y
Q
R
Y
N
E
--
I
Y
P
L
E
------------
E
G
-----------
Y
L
-
E
R
-
K
L
I
-
Y
Q
L
Y
Y
------
L
L
N
-
F
------
S
-------
Y
R
Y
-----------------------------------------------
48
HHSearch
61.06
16%
13
- C2 -
-
4OCV
2
?
A:
[24-316]
----------------------------------------
T
N
E
A
L
F
D
V
A
S
-----
H
F
A
LEGT-
V
D
S
I
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G
D
G
H
-
I
-
N
T
T
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Y
L
-
V
T
---
T
D
-
G
-
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---------
R
Y
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L
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------
R
-
M
N
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G
---
I
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T
--
V
-
N
L
M
R
N
V
E
L
V
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--
L
K
A
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Q
---
G
-----
K
E
T
L
D
---
I
V
R
T
T
-----
S
GDTWAE-----
I
------
D
G
--
G
A
W
R
V
Y
K
--------------
F
I
E
H
T
-
M
S
----
Y
---
N
------
L
VP-------
N
---------
P
D
V
F
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A
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-
R
A
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G
D
F
Q
--------
N
F
L
---------------------
S
-------------
G
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---
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E
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IAHFHD
T
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-----
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---
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P
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E
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T
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N
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L
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N
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-----
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A
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-
D
L
D
T
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G
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M
L
F
D
F
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D
-
S
I
-
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-----------------
F
G
A
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T
ALEDERDLDK
V
H
F
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----
T
E
L
------------
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R
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-
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S
I
T
------------
A
R
-----------
E
A
-
E
L
-
L
P
F
-
S
G
------------------------------------------------------------------------------
74
Fugue
61.03
15%
-36
- C2 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
--------------------
T
L
P
A
V
I
S
R
W
L
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V
--
L
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G
G
A
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---
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---
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Y
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G
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-----
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P
V
P
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---
V
R
W
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-----
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G
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G
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T
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ADAP
A
---
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R
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Q
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-
A
A
L
A
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L
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--------
S
I
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N
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A
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L
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L
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N
V
L
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Y
R
-
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--
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-----
Q
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P
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V
-
A
V
L
D
W
E
M
V
A
L
G
P
R
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L
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V
A
W
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M
I
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-----------------
A
H
R
V
F
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A
TLPGLPEVMR
E
D
D
V
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R
A
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Q
A
--
L
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V
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L
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-----------
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L
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H
W
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F
Y
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G
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M
------
W
A
C
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V
------
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R
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A
R
R
V
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F
---
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K
P
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D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-------------
38
HHSearch
60.63
16%
-9
- C2 -
-
6EF6
2
?
A:
[44-319]
----------------------------------------------------------------
A
S
L
R
L
L
-
N
L
S
-
E
-
N
A
T
-
Y
L
-
V
E
---
D
G
-
E
-
H
---------
Q
S
I
L
R
------
V
-
H
R
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Q
D
---
Y
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P
--
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S
E
L
D
W
L
A
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--
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---
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-----
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T
V
P
T
---
V
V
P
A
R
-----
D
GRR
V
V
T
V
D
P
A
D-------
V
P
--
R
H
V
V
H
F
E
--------------
M
V
G
G
A
-
E
P
----
D
---
E
------
E
SL-------
T
---------
L
D
D
F
Q
T
L
-----------
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-
R
I
T
A
S
L
H
--------
E
H
S
---------------------
Q
-------------
R
---------
W
---------
T
R
---------
P
AG
F
G
----------
R
-
F
-------
S
-----
W
D
W
E---------
H
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C
L
---
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DTP--
R
WGR--
W
Q
D
-----
A
-------
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GV-
G
A
---
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-------
E
---
T
A
L
L
T
R
A
Q
D
L
-------
L
----
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R
K
---
L
----
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--------
E
Y
GS---
G
--
P
D
R
--
Y
G
---------
L
I
H
A
D
L
R
L
A
N
L
L
-
V
D
-
S
--
S
TPQ--
R
-
T
-
I
T
V
I
-
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
-
S
-----------------
F
I
E
H
D
------------
P
R
L
----
G
E
W
------------
Q
E
S
W
-
V
A
G
Y
R
S
--
R
R
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L
P
------------
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A
-----------
D
E
-
A
M
-
L
P
S
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F
V
F
L
R
------
R
L
L
-
L
------
L
-------
A
W
M
---
G
-------------------------------------------
75
Fugue
59.73
15%
-1
- C2 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
-----------------------------
L
S
A
E
--
D
-
A
K
K
L
T
E
L
A
E
N
V
L
Q
-----
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W
D
-----
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Q
--
A
E
K
I
D
V
I
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Q
-
A
L
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W
K
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V
H
---
T
D
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S
-
G
---------
A
V
C
L
K
------
R
-
I
H
-
R
----
P
---
E
--
K
-
K
A
-
L
F
S
I
F
A
Q
D
Y
--
L
A
K
-
K
---
G
MN
V
P
G
I
L
P
N
K
---
K
G
S
L
Y
-----
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-----------
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------
H
G
--
S
F
L
F
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V
Y
--------------
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W
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R
P
----
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---
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------
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---------
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K
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K
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L
A
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H
--------
T
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Q
P
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NG
V
P
I
F
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W
---
P
-------------
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---------
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---------
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T
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---
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----------
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M
----
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T
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Y
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P
W
T
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-----
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K
K
S
--
P
N
---------
L
C
H
Q
D
Y
G
T
G
N
T
L
L
G
E
-
N
--
E
-----
Q
-
I
-
W
-
V
I
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D
L
D
T
V
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D
L
P
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D
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L
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D
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N
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M
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--
R
A
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L
T
------------
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Q
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M
F
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M
L
F
P
Y
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------
L
Y
D
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V
------
I
-------
R
E
K
YVR
K
S
A
L
----
P
K
E
E
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
-------------
57
SP3
59.54
14%
16
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---------------------------------------
A
K
M
R
I
S
P
E
L
K
K
-----
L
I
E
-----
K
Y
R
C
V
K
D
T
E
G
M
-
S
-
P
A
K
V
Y
K
-
L
V
---
G
E
-
N
-
E
---------
N
L
Y
L
K
------
M
-
T
D
-
S
R
YKG
T
---
T
--
Y
-
D
V
-
E
R
E
K
D
M
M
L
W
--
L
E
G
-----
K
-----
L
P
V
P
K
---
V
L
H
F
E
-----
R
-----------
H
------
D
G
--
W
S
N
L
L
M
S
--------------
E
A
D
G
V
-
L
C
----
S
---
E
------
E
Y
EDEQS---
P
---------
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K
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Y
-----------
A
-
E
C
I
R
L
F
H
--------
S
I
D
---------------------
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-------------
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---------
D
---------
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P
---------
Y
---
T
----------
N
-
S
-------
L
-----
D
S
R
----------
L
-
A
E
---
L
-----
D
-----
Y
L
L
-----
N
N
DLADVD
C
---
E
----
N
WEEDTP-
F
---
K
D
P
R
E
L
-----------
Y
----
D
F
L
---
K
----
T
--------
E
K
-----
P
--
E
E
E
--
L
V
---------
F
S
H
G
D
L
G
D
S
N
I
F
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V
K
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D
--
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V
-
S
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F
I
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D
L
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S
G
R
A
D
K
W
Y
D
I
A
F
-
C
V
-
R
-----------------
S
I
R
E
D
------------
I
G
E
----
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Q
Y
------------
V
E
L
F
-
F
D
L
L
----
G
I
K
P
D
------------
W
E
-----------
K
I
-
K
Y
-
Y
I
L
-
L
D
E
L
F
---------------------------------------------------------------------------
50
HHSearch
57.56
15%
-19
- C2 -
-
3F7W
7
?
A:
[5-286]
--------------------------------------------
V
A
A
R
V
T
-----
E
L
T
GRE--
V
A
A
V
A
E
R
G
H
S
H
-
R
-
W
H
L
-
Y
R
-
V
E
---
L
A
-
D
G
T
---------
P
L
F
V
K
------
A
-
L
P
-
D
D
---
A
PAL
D
--
G
-
L
F
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R
A
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A
L
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L
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W
--
L
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S
F
---
G
-----
S
P
V
P
Q
---
V
A
G
W
D
----------------------------
D
R
T
L
A
M
E
--------------
W
V
D
E
R
-
P
P
----
T
------------------------------
P
E
A
A
E
R
F
-----------
G
-
H
Q
L
A
A
M
H
--------
L
A
G
---------------------
A
-------------
E
---------
S
---------
F
G
---------
A
T
W
-
D
G
Y
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L
P
M
D
N
T
-
P
-------
R
-----
S
T
W
P
---------
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-
F
Y
---
A
-----
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L
P
Y
L
R
-----
R
-------
A
---
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----
D
R
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P
G
D
---
V
R
L
V
E
K
-----------
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----
L
D
A
---
L
----
D
--------
H
L
-----
A
G
D
P
E
P
--
P
A
---------
R
I
H
G
D
L
W
N
G
N
V
L
-
W
Q
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--
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-----
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A
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L
A
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L
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F
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----
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P
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------------
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D
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V
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R
D
A
Y
N
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V
A
P
L
A
------------
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G
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R
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A
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L
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L
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-------
C
L
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---
G
A
A
Y
----
R
T
T
L
V
D
T
A
R
A
A
L
------------------------
46
HHSearch
57.52
17%
36
* C2 *
-
4R7B
-
?
A:
[28-274]
-------------------------------------------
K
I
S
S
L
L
S
-----
Q
E
E
E----
V
L
S
V
E
Q
L
-
G
G
M
-
T
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N
Q
N
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Y
L
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A
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---
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T
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N
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---------
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Y
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------
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G
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G
---
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I
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L
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L
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G
-----
L
D
V
K
N
---
Y
L
F
D
I
-------------------------
E
--
A
G
I
K
V
N
E
--------------
Y
I
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S
A
I
T
L
----
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---
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------
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S
--------
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---------
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T
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H
--------
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S
A
---------------------
K
-------------
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---------
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---------
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---------
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P
F
---------
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E
-------
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-----
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K
Y
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---------
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L
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---
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-----
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-----
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----
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-------
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---
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----
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S
L
---
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----
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--------
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D
L
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V
D
--
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---------
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C
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V
P
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N
F
I
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-----
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S
M
N
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M
W
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L
A
A
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L
F
-
L
-----------------
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S
--
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------------
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T
----
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------------
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--
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--------------
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-----------
S
H
-
E
K
-
I
A
I
-
Y
K
I
L
Q
------
D
T
I
-
W
------
S
-------
L
W
------------------------------------------------