@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : R4YP55_OLEAN: (2019-02-01 )
MDITLNYIKNNFANIINIVKPKNQGKLSCVYFADYNDTKIVIKIPMNAGSLSKEIQFYELLKNIELPSPKILSYNYKNIYRIPEYLIMTKLNGAPLHDNCCNDSTKFKIYADIGIYLKMIHSINYFSYSTTFTPYSCDGVINFNSWIEYLNSEIGVILNKVQLSGIFSVYHVEKFRNHFKKLVNIDYNLVLLHGDLGPDHLYFRHDKFEGIIDPGLSFLGPKEYDLAYMAIYTDPHYFHKIASTYGPYSQELVDSLMLLILSQKILRHFENEKVINIEKFINVISTYKLLD
Atome Classification :
(20 SA)
------------------------....-------------.-....10-...-------.-..----.------.20..----------....-..30....--.---------..------.40-.-..----.-.-----.----.---.----50--.......-..60..-.-...-..70.......-.---.--80.--..--....-.90...-.....100---------.---..-....-..110..-.....120---..---......130...--...-.140.-......150----...-..----....160.---..--...---.---170--.-..-.....180.-.--.--.--..-.----190.......200..-..----.----...210.......220.-..-..-----..-----230--------------------..---.--------------------.-----...----------------..240..-.------..-----.-.250...-....260...-....----270..-------......280.-..-....290------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------M
D
I
T
-------------
L
-
N
Y
I
K
N
N
-
F
A
N
-------
I
-
I
N
----I------VKPKN----------QG
K
L
-
S
C
V
Y
F
ADY--N---------D
T
------
K
I
V
-
I
-
K
I
----P-M-----N----A---G----S---
L
S
K
E
I
Q
F
-
Y
E
L
L
K
N-I-ELP-SP
K
-
I
L
S
Y
N
Y
K
-
N
---
I
--YRI--
P
E
--
Y
L
I
M
-TKLNGA-PLHDNC-----------C---ND-ST
K
F
-
K
I
Y
A
D
I
G
-
I
Y
L
K
M
I
-
H
---SI---
N
Y
F
S
Y
S
T
T
FTPY--SCD-
G
V
I
N
F
-
N
S
W
I
E
Y
L
------
N
S
E
-
I
G
----
V
I
L
N
K
V
Q
L
---
S
G
--
I
F
S
---
V
---
Y
H
---
V
-
E
K
-
F
R
N
H
F
K
K
L
V-N--I--D--
Y
N
-
L
----
V
L
L
HGDLGPD
H
L
-
Y
F
-RH----D----KFEGIIDP
G
L
S
FLGPKE-Y
D
-
L
A
-----
Y
M
-----
A
----------------------
I
Y---T--------------------D-----
P
H
Y
----------------
F
H
K
I
A
S
T-Y------GP-----
Y
-
S
Q
E
L
V
D
S
-
L
M
L
L
I
L
S
Q
K
I
-
L
R
H
F----EN-E
K
-------
V
I
N
I
E
K
F
I
N
V
-
I
S
-
T
YKLLD-------------------------------------------
53
HHSearch
81.02
17%
-32
- C4 -
-
3TDW
1
?
A:
[7-280]
--------------------------
H
Y
-------------
T
-
T
M
I
M
T
Q
-
F
P
D
I------
S
-
I
Q
----
S
------
V
E
S
L
G
----------
E
G
F
R
-
N
Y
A
I
L
V
N
--------------
G
------
D
W
V
-
F
-
R
F
----
P
-
K
-----
S
----
Q
Q
G
A
D
----
E
---
L
N
K
E
I
Q
L
-
L
P
L
L
V
G
C
V
-
K
V
N
-
I
P
Q
-
Y
V
Y
I
G
K
R
--------
S
D
G
--
N
P
--
F
V
G
Y
-
R
K
V
Q
G
Q
-
I
L
G
E
D
G
-----------
M
A
V
L
P
D
-
D
A
K
D
-
R
L
A
L
Q
L
A
-
E
F
M
N
E
L
-
S
---
A
F
---
P
V
E
T
A
I
S
-
A
---------
G
V
-
P
V
-
T
N
L
K
N
K
I
------
L
L
L
-
S
E
----
A
V
E
D
Q
V
F
-----
P
--
L
L
D
---
E
---
S
L
---
R
-
D
Y
-
L
T
L
R
F
Q
S
Y
M
-
T
--
H
PV
Y
T-
R
Y
T
P
----
R
L
I
H
G
D
L
S
P
D
H
F
-
L
T
-
N
L
NSRQ
T
----
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
-
Y
D
-
Y
V
-----
Y
L
-----
L
----------------------
E
D
---
C
--------------------
G
-----
E
-
L
----------------
F
T
R
Q
V
M
A
-
Y
------
R
G
-----
E
V
D
L
D
T
H
I
R
-
K
V
S
L
F
V
T
F
D
Q
-
V
S
Y
L
----
L
E
-
G
L
-------
R
A
-------------------------------------------------------------
40
SP3
78.67
19%
6
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------AK
M
R
I
S
---------------
P
E
L
K
K
L
-
I
E
K
---------
Y
R
----
C
------
V
K
D
T
E
----------
G
M
S
P
-
A
K
V
Y
K
L
V
G
--
E
---------
N
E
------
N
L
Y
-
L
-
K
M
----
T
-
D
SRYKG
T
----
T
---
Y
----
D
---
V
E
R
E
K
D
M
-
M
L
W
L
E
--
G
-
K
L
P
-
V
P
K
-
V
L
H
F
-----------
E
R
H
--
D
G
W
S
N
L
L
M
-
S
E
A
D
G
V
-
L
C
S
E
E
Y
-----------
E
---
D
E
-
Q
S
P
E
-
K
I
I
E
L
Y
A
-
E
C
I
R
L
F
-
H
---
S
I
---
D
---------
I
S
--
D
C
P
-
Y
T
N
S
L
-
D
S
R
L
A
E
L
------
D
Y
L
-
L
N
----
N
D
L
A
D
V
D
C
---
E
N
--
W
E
E
---
D
---
T
P
---
F
-
K
D
-
P
R
E
L
Y
D
F
L
K
-
T
E
K
P
--
E
--
E
E
-
L
----
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
-
K
D
----
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
-
Y
D
-
I
A
-----
F
C
-----
V
R
S
I
R
E
-----------------
D
I
---
G
--------------------
E
-----
E
Q
Y
----------------
V
E
L
F
F
D
L
-
L
------
G
------------------------------------------------
I
K
P
D
--
W
E
K
-
I
K
-
Y
Y
I
L
L
D
E
LF----------------------------------------
34
Fugue
77.21
14%
-21
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
---------------SAFT
F
Q
T
L
H
P
D
T
I
-------------
M
-
D
A
L
F
E
H
-
G
I
R
-------
V
-
D
S
----
G
------
L
T
P
L
N
----------
S
Y
E
N
-
R
V
Y
Q
F
Q
D
E
--
D
---------
R
R
------
R
F
V
-
V
-
K
F
Y
RPE
R
-
W
-----
T
----
A
---
D
----
Q
---
I
L
E
E
H
Q
F
-
A
L
Q
L
V
N
-
D
-
E
V
P
-
V
A
A
-
P
V
A
F
N
G
Q
-
T
---
L
--
L
N
H
QG
F
Y
--
F
A
V
F
-
P
S
V
G
G
R
-
Q
F
--------------------
E
-
A
D
N
I
-
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
-
H
---
Q
T
---
G
------
R
K
Q
L
F
--
I
H
R
-
P
T
I
G
L
-
N
E
Y
L
I
E
P
------
R
K
L
-
F
E
----
D
A
T
L
I
P
S
G
---
L
K
--
A
A
F
---
L
---
K
A
---
T
-
D
E
-
L
I
A
A
V
T
A
H
W
-
R
--
E
--
D
--
F
T
-
V
----
L
R
L
H
G
D
C
H
A
G
N
I
-
L
W
-
R
D
----
G
------
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
-
Q
D
-
L
W
-----
M
L
-----
L
NGD-------------------
K
A
---
E
--------------------
Q
-----
R
M
Q
----------------
L
E
T
I
I
E
A
-
Y
E
E
FSEF
D
T
-----
A
-
E
I
G
L
I
E
P
-
L
R
A
M
R
L
V
Y
Y
L
-
A
W
L
M
----
R
R
-
W
A
-------
D
P
A
F
P
K
N
F
P
W
-
L
T
-
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY-------------------
51
HHSearch
76.84
17%
-9
- C- -
-
3N4U
-
?
A:
[8-283]
--------------------------
Q
V
-------------
E
-
K
A
I
E
Q
L
-
Y
P
D
F------
T
-
I
N
----
T
------
I
E
I
S
G
----------
E
G
N
D
-
C
I
A
Y
E
I
--------------
N
R
------
D
F
I
-
F
-
K
F
----
P
-
K
-----
H
----
S
R
G
S
T
----
N
---
L
F
N
E
V
N
I
-
L
K
R
I
H
N
K
L
-
P
L
P
-
I
P
E
-
V
V
F
T
G
M
P
-
S
---
E
--
T
Y
Q
--
M
S
--
F
A
G
F
-
T
K
I
K
G
V
-
P
L
T
P
L
L
-----------
L
N
N
L
P
K
-
Q
S
Q
N
-
Q
A
A
K
D
L
A
-
R
F
L
S
E
L
-
H
---
S
I
---
N
I
S
G
F
K
S
--
N
-----------
L
V
-
L
D
F
R
E
K
I
------
N
E
D
-
N
K
----
K
I
K
K
L
L
S
-----
R
--
E
L
K
---
G
---
P
Q
---
M
-
K
K
-
V
D
D
F
Y
R
D
I
L
-
E
--
N
E-
I
YF
K
Y
Y
P
----
C
L
I
H
N
D
F
S
S
D
H
I
-
L
F
-
D
T
EK--
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
-
N
D
-
F
I
-----
S
L
-----
M
----------------------
E
D
DEE
Y
--------------------
G
-----
M
E
F
----------------
V
S
K
I
L
N
H
-
Y
------
K
H
-----
K
D
I
P
T
-
V
L
E
-
K
Y
R
M
K
E
K
Y
W
S
-
F
E
K
I
----
I
Y
-
G
K
-------
E
Y
G
------------------------------------------------------------
62
HHSearch
71.28
15%
-62
- C4 -
-
3W0S
2
KHYB_ECOLX
A:
[10-235]
--------------------------
S
V
-------------
E
-
K
F
L
I
E
K
-
F
D
--------
S
-
V
S
----
D
------
L
M
Q
L
S
----------
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
---------
G
R
------
G
Y
V
-
L
-
R
V
----
N
-
S
-----
C
----
A
---
D
----
G
---
F
Y
K
D
R
Y
V
-
Y
R
H
F
A
S
-
A
-
A
L
P
-
I
P
E
-
V
L
D
I
G
E
F
-
S
-------
E
S
--
L
T
--
Y
C
I
S
-
R
R
A
Q
G
V
-
T
L
Q
D
L
P
-----------
E
------
T
E
L
P
-
A
V
L
Q
P
V
A
-
E
A
M
D
A
I
-
A
---
A
A
---
D
L
S
Q
T
S
G
-
F
G
P
F
GP
Q
G
I
-
G
--
Q
Y
-
T
T
W
R
D
F
I
------
C
A
I
-
A
D
----
P
H
V
Y
H
W
Q
-----
T
--
V
M
D
---
D
---
T
V
---
S
-
A
S
-
V
A
Q
A
L
D
E
L
M
-
L
--
W
A
-
E
DC
P
E
V
R
----
H
L
V
H
A
D
F
G
S
N
N
V
-
L
T
-
D
N
----
G
----
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
-
Y
E
-
V
A
-----
N
I
-----
F
----------------------
F
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
SP3
70.02
13%
-1
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------------G
M
K
E
L
L
S
T
M
D
L
D
TDANTI
P
E
L
K
E
R
A
H
-
M
L
C
A
R
F
-
L
G
G
-------
A
-
W
K
----
T
------
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
-
F
L
C
R
L
S
E
V
--
Y
---------
P
P
IRNEPN
K
V
L
-
L
-
R
V
----
Y
-
F
-----
N
----
P
---
E
----
T
E
S
H
L
V
A
E
S
V
I
-
F
T
L
L
S
E
-
R
-
H
L
--
G
P
K
-
L
Y
G
I
F
---------------
S
G
--
G
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
--------------
C
---
H
E
-
I
S
L
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
V
-
H
---
Q
L
---
E
---
V
P
I
W
K
E
P
D
--
Y
L
C
-
E
--
A
L
-
Q
R
W
L
K
Q
L
------
T
G
T
-
V
D
AE
H
R
F
D
L
P
E
E
C
G
---
V
S
--
S
V
N
---
C
---
L
D
---
L
-
A
R
-
E
L
E
F
L
R
A
H
I
S
L
--
S
--
K
--
S
P
-
V
----
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
-
P
K
----
R
----
L
V
--
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
-
F
A
N
H
F
I
E
W
T
-----
I
----------------------
D
Y
---
D
--------------------
I
-----
D
E
A
P---------------
F
Y
K
I
Q
T
E
-
N
------
F
P
-----
E
-
N
D
Q
M
L
E
F
-
F
L
N
Y
L
R
E
Q
G
N
-
T
R
------
E
N
-
E
L
-------
Y
K
K
S
E
D
L
V
Q
E
-
T
L
-
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
25
Fugue
69.74
18%
24
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
------------------------
A
K
M
R
-------------
I
S
P
E
L
K
K
L
-
I
E
K
-------
Y
-
R
C
----
V
------
K
D
T
E
G
----------
M
S
P
A
-
K
V
Y
K
L
V
G
E
--
N
---------
E
N
------
L
Y
L
-
K
-
M
T
----
D
-
S
-----
R
YKGT
T
---
Y
----
D
---
V
E
R
E
K
D
M
-
M
L
W
L
E
G
---
K
L
P
-
V
P
K
-
V
L
H
F
E
R
H
-
D
---
G
-------
W
S
--
N
L
L
M
-
S
E
A
D
G
V
-
L
C
S
E
E
Y
-----------
E
---
D
E
-
Q
S
P
E
-
K
I
I
E
L
Y
A
-
E
C
I
R
L
F
-
H
---
S
I
---
D
I
S
D
C
P
Y
T
--------
N
-
S
L
D
S
R
-
L
A
E
L
D
Y
L
------
L
N
N
-
D
L
----
A
D
V
D
C
E
N
W
---
E
E
--
D
T
P
---
F
---
K
D
---
P
-
R
E
-
L
Y
D
F
L
K
T
E
K
-
P
--
E
--
E
---
E
-
L
----
V
F
S
H
G
D
L
G
D
S
N
I
-
F
V
-
K
D
----
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
-
Y
D
-
I
A
-----
F
C
-----
V
----------------------
R
S
---
I
--------------------
R
-----
E
D
I
----------------
G
E
E
-------------
Q
-----
Y
-
V
E
L
F
F
D
L
-
L
--------------------------------
G
I
K
P
D
W
E
K
-
I
K
-
Y
Y
I
L
L
D
E
LF----------------------------------------
33
Fugue
66.83
15%
8
- C4 -
-
3DXP
1
?
A:
[20-359]
-------------------------
R
F
D
-------------
T
-
E
A
L
E
A
W
M
R
Q
H
-------
V
-
E
G
FAGP
L
------
S
V
E
Q
F
----------
K
G
Q
S
-
N
P
T
F
K
L
V
T
--
P
---------
G
Q
------
T
Y
V
M
R
-
A
-------------
K
----
P
---
G
----
A
---
I
E
R
E
Y
R
V
M
D
A
L
-
A
G
-
T
-
D
V
P
-
V
A
K
M
Y
A
L
C
E
D
E
-
S
---
V
----
I
--
G
R
--
A
F
Y
I
M
E
F
V
S
G
R
-
V
L
W
D
Q
S
-----------
L
---
P
G
M
S
P
A
E
-
R
T
A
I
Y
D
E
M
N
R
V
I
A
A
M
H
---
T
V
---
D
Y
Q
A
I
-------------
G
L
G
D
Y
-
G
K
P
G
N
Y
F
------
Q
R
Q
-
I
E
----
R
W
T
K
Q
Y
K
L
---
S
E
--
T
E
S
---
I
---
P
A
M
D
S
L
M
D
W
-
L
P
Q
H
I
P
Q
---
E
--
D
--
A
--
D
L
-
T
----
S
I
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
E
----
P
----
R
V
L
A
V
L
D
W
E
L
S
T
L
G
-
H
P
M
G
D
-
F
G
-----
Y
H
-----
C
MSWHIAPGQFRGIAGLDHAALG
I
P
---
D
--------------------
E
-----
A
S
Y
----------------
R
K
L
Y
E
Q
R
-
T
------
G
R
PITGD
W
-
N
F
Y
L
A
F
S
M
F
R
I
A
G
I
L
Q
G
I
M
K
R
V
V
D
GTA
S
S
-
A
Q
-------
A
L
D
A
G
K
R
A
R
P
M
A
E
M
G
W
E
Y
A
K
K
AKQ---------------------------------------
19
PsiBlast_PDB
65.72
24%
-12
- C4 -
-
4DCA
1
?
A:
[61-253]
-----------------------------------------------------------------------------------------------------------------------------
V
-
V
-
K
V
----
P
-
K
-----
R
----
D
---
S
V
R
I
-
S
---
Q
K
R
E
L
E
L
-
Y
R
F
L
E
N
-
C
-
K
L
--
S
Y
Q
-
I
P
A
V
V
Y
Q
S
D
---
R
--
F
N
I
--
M
K
--
Y
I
K
G
-
E
R
I
T
Y
E
-
Q
Y
H
K
-------------
L
---
S
E
-
K
E
K
D
-
A
L
A
Y
D
E
A
-
T
F
L
K
E
L
-
H
---
S
I
---
E
I
D
C
S
V
S
L
F
S
------
D
-
A
L
V
N
K
-
K
D
K
F
L
Q
D
------
K
K
L
-
L
I
----
S
I
L
E
K
E
Q
L
---
L
T
--
D
E
M
---
L
---
E
H
---
I
-
E
T
I
Y
E
N
I
L
S
N
A
V
-
L
--
F
--
K
--
Y
T
-
P
----
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
-
R
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
-
N
D
F
L
C
-----
L
L
-----
D
----------------------
C
S
---
T
--------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
65.00
13%
-45
- C4 -
-
1NW1
-
CKA2_CAEEL
B:
[56-356]
---------------------------
A
-------------
H
-
M
L
C
A
R
F
-
L
G
G
AWKTVPL
E
-
H
L
----
R
------
I
S
R
I
K
----------
G
G
M
S
-
N
M
L
F
L
C
R
L
--
S
EVYPPIRNE
P
N
------
K
V
L
-
L
-
R
V
----
Y
-
F
-----
N
----
P
ET
E
S
----
H
---
L
V
A
E
S
V
I
-
F
T
L
L
S
E
-
R
-
H
L
G
--
P
K
-
L
Y
G
I
F
S
---------------
G
--
G
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
H
E
-----------
I
-------
S
L
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
V
-
H
---
Q
L
---
E
V
P
I
W
K
E
---
P
D
--
Y
-
L
-
C
E
-
A
L
-
Q
R
W
L
K
Q
L
------
T
G
T
-
V
D
----
A
E
H
-
R
F
D
L
---
P
E
EC
G
V
S
---
S
---
V
N
---
C
-
L
D
-
L
A
R
E
L
E
F
L
R
-
A
--
H
I
-
S
L
S
K
S
P
V
----
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
-
P
K
----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
-
F
A
-----
N
H
-----
F
----------------------
I
E
---
W
T
IDYDIDEAPF
Y
K
I
Q
TENFP
E
-----
N
D
Q
----------------
M
L
E
F
F
L
N
-
Y
------
L
R
-----
E
-------------------------------------------------------------------------------------------------------
30
Fugue
64.93
13%
-2
- C4 -
-
3JR1
3
?
A:
[14-309]
----------------N
L
Y
F
Q
G
M
W
K
S
I
S
-------------
Q
-
V
L
A
E
Q
F
-
G
A
Y
-------
Y
-
F
I
----
K
------
H
K
E
K
L
----------
Y
S
G
E
M
N
E
I
W
L
I
N
D
--
E
---------
V
Q
------
T
V
F
-
V
-
K
I
----
N
E
R
-----
S
----
Y
---
R
----
S
M
--
F
R
A
E
A
D
Q
-
L
A
L
L
A
K
-
T
-
N
---
S
I
N
-
V
P
L
V
Y
G
I
-
G
---
N
--
S
Q
G
--
H
S
--
F
L
L
L
-
E
A
L
N
K
S
-
K
N
K
Q
S
-------------------------
S
F
T
I
F
A
-
E
K
I
A
Q
L
-
H
Q
IQ
G
P
---
D
K
Y
G
L
D
F
D
T
W
L
G
--
P
I
Y
-
Q
P
N
D
W
Q
T
S
W
A
K
F
F
------
S
E
N
R
I
G
----
W
Q
L
Q
I
C
K
E
---
K
G
---
L
I
---
F
---
G
N
---
I
-
D
L
-
I
V
Q
I
V
A
D
T
L
S
K
--
H
--
N
--
P
K
-
P
----
S
I
L
H
G
N
L
W
I
E
N
C
-
I
Q
-
V
D
----
D
----
K
I
F
-
V
C
N
P
A
C
-
Y
W
G
D
R
E
-
C
D
-
I
A
-----
F
S
-----
S
----------------------
L
F
---
E
--------------------
P
F----
P
T
N
----------------
F
Y
Q
R
Y
N
E
-
I
------
Y
P
-----
L
-
E
E
G
Y
L
E
R
-
K
L
I
Y
Q
L
Y
Y
-
L
-
L
N
F
S
----
Y
R
-
Y
Y
-------
N
K
K
Q
S
Y
V
S
L
T
-
Q
K
-
L
I
N
Q
I
L
HK-----------------------------------------
58
HHSearch
64.91
17%
-4
- C4 -
-
4R78
2
?
A:
[25-278]
---------------------------
I
-------------
K
-
E
K
I
S
S
L
-
L
S
Q
EE-----
E
-
V
L
----
S
------
V
E
Q
L
-----------
G
G
M
T
-
N
Q
N
Y
L
A
K
T
--
T
---------
N
K
------
Q
Y
I
-
V
-
K
F
----
F
-
G
-----
K
----
G
---
T
EKLI
N
---
R
Q
D
E
K
Y
N
-
L
E
L
L
K
D
-
L
-
G
L
D
-
V
K
N
-
Y
L
F
D
I
E
--------------
A
G
--
I
K
V
N
-
E
Y
I
E
S
A
I
T
L
D
S
T
S
--------------------
I
K
-
T
K
F
D
K
I
A
-
P
I
L
Q
T
I
-
H
---
T
S
---
A
K
E
L
R
G
E
-
F
A
-----------
P
F
-
E
E
I
K
-
K
Y
------
E
S
L
-
I
E
----
E
Q
I
--------------
P
---
Y
---
A
N
---
Y
-
E
S
-
V
R
N
A
V
F
S
L
E
-
K
--
R
L
A
D
L
-
G
V
D
R
----
K
S
C
H
I
D
L
V
P
E
N
F
-
I
E
-
S
P
----
Q
----
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
-
W
D
-
L
A
-----
A
L
-----
F
----------------------
L
E
S
E-
F
--------------------
T
-----
S
Q
E
----------------
E
E
T
F
L
S
H
-
Y
------
E
S
-----
D
Q
T
P
V
-
S
H
E
-
K
I
A
I
Y
K
I
L
Q
D
-
T
I
W
S
----
L
W
-
T
V
-------
Y
K
-------------------------------------------------------------
18
PsiBlast_PDB
64.59
24%
-6
- C4 -
-
3UZR
5
?
A:
[61-253]
-----------------------------------------------------------------------------------------------------------------------------
V
-
V
-
K
V
----
P
-
K
-----
R
----
D
---
S
V
R
I
-
S
---
Q
K
R
E
L
E
L
-
Y
R
F
L
E
N
-
C
-
K
L
--
S
Y
Q
-
I
P
A
V
V
Y
Q
S
D
---
R
--
F
N
I
--
M
K
--
Y
I
K
G
-
E
R
I
T
Y
E
-
Q
Y
H
K
-------------
L
---
S
E
-
K
E
K
D
-
A
L
A
Y
D
E
A
-
T
F
L
K
E
L
-
H
---
S
I
---
E
I
D
C
S
V
S
L
F
S
------
D
-
A
L
V
N
K
-
K
D
K
F
L
Q
D
------
K
K
L
-
L
I
----
S
I
L
E
K
E
Q
L
---
L
T
--
D
E
M
---
L
---
E
H
---
I
-
E
T
I
Y
E
N
I
L
S
N
A
V
-
L
--
F
--
K
--
Y
T
-
P
----
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
-
R
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
-
N
D
F
L
C
-----
L
L
-----
D
----------------------
C
S
---
T
--------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
64.36
13%
-45
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[56-356]
---------------------------
A
-------------
H
-
M
L
C
A
R
F
-
L
G
G
AWKTVPL
E
-
H
L
----
R
------
I
S
R
I
K
----------
G
G
M
S
-
N
M
L
F
L
C
R
L
--
S
EVYPPIRNE
P
N
------
K
V
L
-
L
-
R
V
----
Y
-
F
-----
N
----
P
ET
E
S
----
H
---
L
V
A
E
S
V
I
-
F
T
L
L
S
E
-
R
-
H
L
G
--
P
K
-
L
Y
G
I
F
S
---------------
G
--
G
R
L
E
-
E
Y
I
P
S
R
-
P
L
S
C
H
E
-----------
I
-------
S
L
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
V
-
H
---
Q
L
---
E
V
P
I
W
K
E
---
P
D
--
Y
-
L
-
C
E
-
A
L
-
Q
R
W
L
K
Q
L
------
T
G
T
-
V
D
----
A
E
H
-
R
F
D
L
---
P
E
EC
G
V
S
---
S
---
V
N
---
C
-
L
D
-
L
A
R
E
L
E
F
L
R
-
A
--
H
I
-
S
L
S
K
S
P
V
----
T
F
C
H
N
D
L
Q
E
G
N
I
-
L
L
-
P
K
----------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
-
F
D
-
F
A
-----
N
H
-----
F
----------------------
I
E
---
W
T
IDYDIDEAPF
Y
K
I
Q
TENFP
E
-----
N
D
Q
----------------
M
L
E
F
F
L
N
-
Y
------
L
R
-----
E
-------------------------------------------------------------------------------------------------------
24
Fugue
63.58
13%
27
- C4 -
-
3HAM
3
?
A:
[1-299]
-----------------------M
V
N
L
D
-------------
A
-
E
I
Y
E
H
L
-
N
K
Q
-------
I
-
K
I
----
N
------
E
L
R
Y
L
----------
S
S
G
D
-
D
S
D
T
F
L
C
N
--
E
---------
Q
Y
------
V
V
K
-
V
P
K
R
----
D
-
S
-----
V
----
R
---
I
----
S
---
Q
K
R
E
F
E
L
-
Y
R
F
L
E
N
-
C
-
K
L
S
-
Y
Q
I
-
P
A
V
V
Y
Q
S
-
D
---
R
--
F
N
I
--
M
K
--
Y
I
K
G
-
E
R
I
T
Y
E
-
Q
Y
H
K
L
----------------
S
E
-
K
E
K
D
-
A
L
A
Y
D
E
A
-
T
F
L
K
E
L
-
H
---
S
I
---
E
I
-------
D
C
S
--
V
S
L
-
F
S
D
A
L
-
V
N
K
K
D
K
F
------
L
Q
D
-
K
K
----
L
L
I
S
I
L
E
K
---
E
Q
--
L
L
T
---
D
---
E
M
---
L
-
E
H
-
I
E
T
I
Y
E
N
I
L
-
N
--
N
--
A
--
V
L
-
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
-
I
F
-
R
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
-
N
D
-
F
L
-----
C
L
-----
L
----------------------
D
C
---
S
--------------------
T
DDFG-
K
E
F
----------------
G
R
K
V
L
K
Y
-
Y
------
Q
H
-----
K
-
A
P
E
V
A
E
R
-
K
A
E
L
N
D
V
Y
W
S
-
I
D
Q
I
----
I
Y
-
G
Y
E
R
KD
R
E
M
L
I
K
G
V
S
E
L
L
Q
-
T
Q
-
A
E
M
F
I
F
-------------------------------------------
54
HHSearch
62.83
14%
-23
- C4 -
-
5IGH
-
?
A:
[12-254]
---------------------------
L
-------------
Y
-
A
L
A
A
R
--
H
G
L
-------
K
L
H
G
----
P
------
L
T
V
N
E
----------
L
G
L
D
-
Y
R
I
V
I
A
T
V
D-
D
---------
G
R
------
R
W
V
-
L
-
R
I
----
P
-
R
-----
R
----
A
E
V
S
A
----
K
---
V
E
P
E
A
R
V
-
L
A
M
L
K
N
R
L
-
P
F
A
-
V
P
D
-
W
R
V
A
N
A
E
-
L
---
V
A
Y
P
M
L
--
E
D
--
S
T
A
M
-
V
I
Q
P
G
S
-
S
T
P
D
W
V
---------------
V
P
-
Q
D
S
E
-
V
F
A
E
S
F
A
-
T
A
L
A
A
L
-
H
---
A
V
---
P
I
S
A
A
V
D
-
A
G
M
L
------
I
R
-
T
P
-
T
Q
A
R
Q
K
V
------
A
D
D
-
V
D
----
R
V
R
R
E
-----------
F
V
-------
V
N
---
D
-
K
R
-
L
H
R
W
Q
R
W
L
D
-
D
--
D
S-
S
W-
P
D
F
S
----
V
V
V
H
G
D
L
Y
V
G
H
V
-
L
I
-
D
N
T---
E
----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
-
I
D
-
M
A
-----
A
H
-----
L
----------------------
M
V
---
F
--------------------
G
-----
E
E
G
----------------
L
A
K
L
L
L
T
-
Y
------
E
A
-----
A
-------------------------------------------------------------------------------------------------------
36
Fugue
62.71
12%
-13
- C4 -
-
3CSV
11
?
A:
[4-333]
---------------------------
S
-------------
R
-
E
D
E
I
R
D
-
F
L
A
-------
T
-
H
G
----
Y
------
A
D
W
N
R
----------
T
P
R
Y
-
Q
R
L
R
S
P
T
---
G
---------
A
K
------
A
V
L
M
D
-
W
S
----
P
-
E
-----
E
----
G
---
G
----
D
---
T
Q
P
F
V
D
L
-
A
Q
Y
L
R
N
-
L
-
D
I
S
-
A
P
E
-
I
Y
A
E
E
H
A
-
R
------------
G
--
L
L
L
I
-
E
D
L
G
D
A
-
L
F
T
E
V
I
-----------
N
---
N
D
-
P
A
Q
E
M
P
L
Y
R
A
A
V
-
D
L
L
I
H
L
-
H
---
D
A
---
Q
T
P
E
L
A
R
L
D
P
E
T
--
L
S
E
M
T
R
L
A
F
-
S
E
Y
R
Y
A
I
------
L
G
D
-
A
A
-------------------------
E
---
D
N
---
R
-
K
R
-
F
E
H
R
F
A
Q
I
L
-
S
--
A
Q
-
L
--
E
G
-
D
M---
V
F
V
H
R
D
F
H
A
Q
N
L
-
L
W
-
L
P
----
E
REGL
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
-
Y
D
-
L
V
-----
S
L
-----
L
----------------------
Q
D
---
A
--------------------
R
-----
R
D
V
----------------
P
A
Q
V
E
A
Q
M
I
------
D
H
-----
Y
-
I
Q
A
T
G
V
D
-
E
S
H
F
R
S
A
Y
A
V
-
I
A
V
Q
----
R
N
M
R
I
-------
L
G
I
F
A
R
L
S
Q
R
-
F
G
-
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
HPALASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A-
31
Fugue
62.61
15%
0
- C4 -
-
3I1A
2
?
A:
[3-330]
-----------------------K
Q
P
I
Q
-------------
A
-
Q
Q
L
I
E
L
-
L
K
V
-------
H
-
Y
G
----
I
DIH
T
A
Q
F
I
Q
G
G
----------
A
D
T
N
-
A
F
A
Y
Q
A
D
S
--
E
---------
S
K
------
S
Y
F
-
I
-
K
L
K
Y
--
G
-
Y
-----
H
----
D
---
E
----
I
---
N
L
S
I
I
R
L
-
L
H
D
S
G
I
-
K
-
E
I
I
-
F
P
I
-
H
T
L
E
A
K
L
-
F
---
Q
--
Q
L
K
--
H
F
--
K
I
I
A
-
Y
P
F
I
H
A
-
P
---
N
G
-----------
F
---
T
Q
-
N
L
T
G
-
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
-
H
---
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
--
S
P
K
-
W
R
E
I
V
-
R
S
F
Y
N
Q
I
EFDNSD
D
K
L
-
T
A
----
A
F
K
S
F
F
N
Q
---
N
S
--
A
A
I
---
H
---
R
L
---
V
-
D
T
-
S
E
K
L
S
K
K
I
Q
-
P
--
D
--
L
--
D
K
-
Y
----
V
L
C
H
S
D
I
H
A
G
N
V
-
L
V
-
G
N
----
E
----
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
-
R
D
-
L
M
-----
F
I
GGGVG
N
----------------------
V
W
---
N
--------------------
K
-----
P
H
E
----------------
I
Q
Y
F
Y
E
G
-
Y
------
G
E
-----
I
-
N
V
D
--
K
T
-
I
L
S
Y
Y
R
H
E
R
I
-
V
E
D
I
----
A
V
-
Y
G
-------
Q
D
L
L
S
R
N
Q
N
N
-
Q
S
-
R
L
E
S
F
K
Y
F
K
E
M
F
DPNN
V
V
E
I
A
F
A
T
E------------------------
60
HHSearch
62.51
15%
-31
- C4 -
-
3I1A
4
?
B:
[10-270]
--------------------------
Q
L
-------------
I
-
E
L
L
K
V
H
-
Y
G
I
-------
D
-
I
H
----
T
------
A
Q
F
I
Q
----------
G
G
A
D
-
T
N
A
F
A
Y
Q
A
D
S
E
---------
S
K
------
S
Y
F
-
I
-
K
L
----
K
-
Y
-----
G
----
Y
---
H
--------
D
E
I
N
L
S
I
-
I
R
L
L
H
D
-
S
-
G
I
K
E
I
I
F
-
P
I
H
T
L
E
A
-
K
L
F
Q
Q
--
L
K
H
--
F
K
--
I
I
A
Y
-
P
F
I
H
A
P
-
N
G
F
T
Q
N
-----------
L
--------
T
G
-
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
-
H
---
E
T
---
S
V
P
I
S
I
Q
-
Q
Q
L
R
----
K
-
E
I
-
Y
S
-
P
K
W
R
E
I
V
------
R
S
F
-
Y
N
----
Q
I
E
F
D
N
S
D
D
K
L
T
A
--
A
F
K
S
F
F
N
Q
N
S
A
A
---
I
-
H
R
-
L
V
D
T
S
E
K
L
S
-
K
--
K
I-
Q
PD
L
D
K
Y
----
V
L
C
H
S
D
I
H
A
G
N
V
-
L
V
-
G
N
----
E
----
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
-
R
D
-
L
M
-----
F
I
-----
G
----------------------
G
G
---
V
--------------------
G
NVWNK
P
H
E
----------------
I
Q
Y
F
Y
E
G
-
Y
------
G
E
-----
I
-------------------------------------------------------------------------------------------------------
28
Fugue
62.37
12%
-30
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
T
L
P
A
V
I
S
R
W
L
S
S
V
LPGGAA
P
E
V
T
V
E
S
G
V
-------------
D
-
S
T
G
M
S
S
-
E
T
I
-------
I
-
L
T
----
A
------
R
W
Q
Q
D
----------
G
R
S
I
-
Q
Q
K
L
V
A
R
V
--
A
---------
P
A
------
A
E
D
-
V
-
P
-----
V
-
F
-----
P
----
T
---
Y
----
R
---
L
D
H
Q
F
E
V
-
I
R
L
V
G
E
-
L
T
D
V
P
-
V
P
R
-
V
R
W
I
E
T
T
-
G
---
D
--
V
L
G
--
T
P
--
F
F
L
M
-
D
Y
V
E
G
V
-
V
P
P
D
V
M
PYTFGDNWFAD
A
---
P
A
-
E
R
Q
R
-
Q
L
Q
D
A
T
V
-
A
A
L
A
T
L
-
H
---
S
I
---
P
N
--
A
Q
N
T
F
S
F
L
--
T
D
T
-
T
L
H
R
H
-
F
N
W
V
R
S
W
------
Y
D
F
-
A
V
----
E
G
I
G
R
S
----------
P
L
---
L
---
E
R
---
T
-
F
E
-
W
L
Q
S
H
W
P
D
D
-
A
--
A
--
A
--
R
E
-
P
----
V
L
L
W
G
D
A
R
V
G
N
V
-
L
Y
-
R
D
----
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
-
L
D
-
V
A
-----
W
M
-----
I
----------------------
F
A
---
H
--------------------
R
-----
V
F
Q
E
L
A
G
L
A
TLPGLPEVMR
E
D
D
V
R
A
T
-
Y
------
Q
A
-----
L
-
T
G
V
E
L
G
D
-
L
H
W
F
Y
V
Y
S
G
V
-
M
W
A
C
----
V
F
-
M
R
-------
T
G
A
R
R
V
H
F
G
E
-
I
E
-
K
P
D
D
V
E
SLFYH
A
G
L
M
K
H
L
L
G
EEH--------------------------