@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_26_2600: (2018-07-13 )
MATPVTDPPKIIGRELHLDRLIGSGGFGEVYLAVRTKLATNPKHNFTFPAECVVKVMRRGLCTEEDVAAMNREVATLSSMDHPYIVAYIGAWVEAARGKFFGCYCLAMKYCEGGDLHGFIAQCIKAHRLPPVDVAVRIMAQVFSALNYSHSRRLIHRDIKPGNVFLTLQKSGVPDKAMVGDYGLVRSLEATRQLVKTRVGTPTYISPEIAAGEAYSTKTDIFSAGTMFYELLSLHRPFWKRMMTDQQLFREVLHRDPMPQFRAYTSSVYGTALADVIEACLTKHEANRATAYDALVRLTSPITAYVLKYAIPVYPEKDALTTSPPRPPAASSAPDGHASAADADGDAATARQRLERLFLVRKGTAVGARLTRLLSHNAELLFQVRVLVACRSDNTDHLENGLAELLWAFPDAEVPFQEVIDLVMSDYRQLAE
Atome Classification :
(35 SA)
-------------------------------------------------------------.........10........20........30........40........50........60.---.......70........80.-........90........100.......110.......120--....-...130.......140.......150.-----......160.......170...--------....180.......190.--......200----.......210--..-.-------.....220.......230.-.-....--.240.......250....--..---------------------.260...--------....270.......280......---.-----290.......300.....------..310....------...320.......330.......340...------....350....---...360.......370.......-------------380.......390.......400......-.410.......420.......430---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------MATPVTD
P
P
K
I
I
G
R
E
L
H
L
D
R
LIGSGGF
G
E
V
Y
L
A
V
R
T
KLATNPKHNFTF
P
A
E
C
V
V
K
V
M
R
RGLC---
T
E
E
D
V
A
A
M
N
R
E
V
A
T
LSSM-D-H
P
Y
I
V
A
Y
I
G
A
W
V
E
A
ARG
K
F
F
G
C
Y
C
L
A
M
K
YCEGG
D
L
H
G
F
I
A
Q
--
C
I
K
A-HRLP
P
V
D
V
A
V
R
I
M
A
Q
V
F
S
A
L
N
Y
S
H
S
R
R
-----
L
I
H
RDIKPG
N
V
F
L
T
L
QKSGVPD--------KAMVG
D
Y
G
L
V
R
S
L
E
A
T
R
Q
--
L
V
K
T
RVGTP----TYISPEIAA---GE-A-------YSTKTDI
F
S
A
G
T
M
F
Y
E
L
L
S
-
L
-
H
R
P
F
--
W
K
R
MM
T
D
Q
Q
L
F
R
E
V
LHRD--P
M
---------------------
P
Q
F
R
A
Y
T
--------
S
S
V
Y
G
T
A
L
A
D
V
I
E
A
C
L
T
K
HEANR---
A
-----
T
A
Y
D
A
L
V
R
LTS
P
I
T
A
Y
V
L
------
K
YAIPVYPE------KDALTTSPPRPPAASSAPDGHASAADADG------
D
A
A
T
A
R
Q
R
L
E
R
---
L
F
L
VRKGT
A
V
G
A
R
L
T
R
L
L
SHN
A
E
-------------
L
L
F
Q
V
R
V
L
V
A
CRSD
N
T
D
H
L
E
N
G
L
A
E
L
L
W
A-FPDAEV
P
F
Q
E
V
I
D
L
V
M
S
D
Y
R
Q
LAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.85
29%
-98
- C1 -
-
2WQM
-
NEK7_HUMAN
A:
[33-295]
---------------------------------------------------------------------------
N
F
R
I
E
K
K
I
G
R
G
--
S
E
V
Y
R
A
A
-
C
L
L
D
G
V
P
V
--------
A
L
K
K
V
Q
I
F
D
L
M
---
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
-
H
P
N
V
I
K
Y
Y
A
S
F
I
E
D
N
E
L
N
------
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
--
F
K
K
Q
-
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-----
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
T
G
V
-----------
V
K
L
G
D
L
--------------------
T
P
----
Y
Y
M
S
P
E
R
I
H
---
E
N
-
G
-------
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
-
Q
S
P
F
--
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
P
P
L
---------------------
P
--------------
S
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
PD
V
T
-----
Y
V
Y
D
V
A
K
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
73.39
21%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
-----------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
----------
Q
V
A
I
K
Q
C
R
Q
E
L
----
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
-
N
-
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
A
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
--
F
E
N
C
-
C
G
L
K
E
G
P
I
R
-
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
-----
I
I
H
R
D
L
K
P
E
N
--
I
V
L
Q
P
G
P
Q
R
L
--------
I
H
K
I
I
D
L
G
Y
A
K
E
L
D
-
Q
G
E
--
L
C
T
E
F
V
G
T
L
----
Q
Y
L
A
P
E
L
L
E
---
Q
K
-
K
-------
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
-
G
-
F
R
P
F
LP
N
W
Q
P
V
Q
W
H
G
K
V
R
I
V
V
Y
D
D
--
L
T
---------------------
G
A
V
K
F
S
S
VLPTPNHL
S
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
---
P
QNPNV
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
MVSGR
V
H
T
Y
P
V
T
E
N
EN
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
------
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
KRPLTYTHL
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
-
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
KLDF
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
QMEFGITSE
K
L
L
S
A
W
R
E
M
EQAVELCGRERE
V
Q
A
L
V
D
KMM
A
L
Q
T
D
S
V
D
L
Q
R
NPT
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
RPRDQRTPGDSND
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
PKVK
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
SKVR-----------------------
3
PsiBlast_PDB
72.63
29%
-100
- C1 -
-
5DE2
-
NEK7_HUMAN
A:
[33-295]
---------------------------------------------------------------------------
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
-
C
L
L
D
G
V
P
V
--------
A
L
K
K
V
Q
I
F
D
L
M
---
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
-
H
P
N
V
I
K
F
Y
A
S
F
I
E
D
N
E
L
N
------
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
--
F
K
K
Q
-
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-----
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
T
G
V
-----------
V
K
L
G
D
L
G
L
----------------
V
G
T
P
----
Y
Y
M
S
P
E
R
I
H
---
E
N
-
G
-------
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
-
Q
S
P
F
--
Y
G
D
K
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
YP
P
L
---------------------
P
--------------
S
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
PD
V
T
-----
Y
V
Y
D
V
A
K
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.12
29%
-97
- C1 -
-
2WQN
1
NEK7_HUMAN
A:
[33-295]
---------------------------------------------------------------------------
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
-
C
L
L
D
G
V
P
V
--------
A
L
K
K
V
Q
I
F
D
L
M
---
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
-
H
P
N
V
I
K
Y
Y
A
S
F
I
E
D
N
E
L
N
------
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
--
F
K
K
Q
-
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-----
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
T
G
V
-----------
V
K
L
G
D
L
--------------------
T
P
----
Y
Y
M
S
P
E
R
I
H
---
E
N
-
G
-------
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
-
Q
S
P
F
--
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
P
P
L
---------------------
P
--------------
S
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
PD
V
T
-----
Y
V
Y
D
V
A
K
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
70.49
25%
-125
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-265]
------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----------
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
-------
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
-----
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
--
K
G
A
--------
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
--
A
W
F
G
F
A
G
T
P
----
G
Y
L
S
P
E
V
L
R
---
K
D
-
P
-------
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
-
Y
P
P
F
--
W
D
E
D
Q
--
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
----------------------
D
-
F
P
S
P
E
--------
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
---
I
-----
T
A
S
E
A
L
K
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
66.75
23%
-119
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-269]
---------------------------------------------------------------------
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
----------
L
E
F
A
A
K
I
I
N
T
K
K
L
---
S
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
------
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
-------
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
-----
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
--
K
G
A
--------
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
---
A
W
H
G
F
A
G
T
P
----
G
Y
L
S
P
E
V
L
K
---
K
D
-
P
-------
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
-
Y
P
P
F
--
W
D
E
D
--
Q
H
R
L
Y
A
Q
I
K
A
G
A
--
Y
D
---------------------
Y
--
P
S
P
E
--------
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
---
I
-----
T
A
D
Q
A
L
K
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
64.28
21%
-102
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
--
S
K
--------
K
T
Y
M
A
K
F
V
K
V
------
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
-----
N
T
S
-
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-----
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
---
S
--------
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
-
P
G
D
--
N
F
R
L
L
F
T
A
P
----
E
Y
Y
A
P
E
V
H
Q
---
H
D
-
V
-------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
-
I
N
P
F
--
L
A
E
--
T
N
Q
Q
I
I
E
N
I
M
N
A
E
--
Y
T
---------------------
F
D
E
E
A
F
K
--------
E
--
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
---
M
-----
T
A
S
E
A
L
Q
H
--------------------
P
W
L
K
Q
------
K
I
E
R
V
S
T
K
V
I
R
T
---------------------------
L
K
H
R
R
Y
Y
---
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
-------------
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
63.00
26%
-118
- C1 -
-
4G3F
1
A:
[58-316]
--------------------------------------------------------------------------
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
----------
F
Q
C
A
V
K
K
V
R
L
E
V
----------
F
R
V
E
E
L
V
A
C
A
G
L
-
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
-------
M
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
-----
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
----
S
--------
R
A
A
L
C
D
F
G
H
A
L
C
L
---------
D
Y
I
P
G
T
E
----
T
H
M
A
P
E
V
V
M
---
G
K
-
P
-------
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
-
C
H
P
W
--
T
Q
Y
F
R
--
G
P
L
C
L
K
I
A
S
E
P
--
P
----------------------
P
-
I
R
-
E
I
--------
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
---
A
-----
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
60.59
23%
-75
- C1 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
------------
N
K
V
A
V
K
C
I
K
---------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
-
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
-----
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G-----
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
-----
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
-------------
V
A
K
V
S
D
F
G
---------------------LLPV
K
W
T
A
P
E
A
L
R
---
E
K
-
K
-------
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
-
F
-
G
R
V
P
--
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
--
K
M
---------------------
D
A
P
D
G
C
P
-------------
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
---
P
-----
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
-------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
60.22
18%
-18
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
-------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
F
Q
-----------
G
R
P
V
A
V
K
R
M
L
--------
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
-
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
------
R
F
L
Y
I
A
L
E
L
C
N
L
N
-----
L
Q
D
--
L
V
E
S
-
K
Y
-----
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
-----
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
R
F
T
A
D
QQTGAEN
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
------------
S
T
S
----
G
W
R
A
P
E
L
L
E
---
E
S
-
N
NLQTKRR
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
-
K
G
K
H
P
F
--
G
D
K
Y
S
R
E
S
N
I
I
R
G
I
F
-----
S
L
---------------------
D
E
M
K
C
L
H
--------
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
---
P
-----
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
------
E
F
L
L
K
V
S
D
R
------
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
-----------
W
T
V
K
F
D
K
---
T
F
M
D
R
K
Y
H
--
S
S
K
L
M
D
L
L
R
A
L
R
N
-------------
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
YS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
60.14
25%
-128
- C1 -
-
1KOB
1
?
A:
[50-305]
-------------------------------------------------------------------------
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
----------
R
V
F
V
A
K
F
I
N
T
P
Y
P
-----
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
--
E
----
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
-----
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
---
A
S
--------
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
---
I
V
K
V
T
T
A
T
A
----
E
F
A
A
P
E
I
V
D
---
R
E
-
P
-------
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
-
L
S
P
F
--
A
G
E
D
--
D
L
E
T
L
Q
N
V
K
R
C
D
--
W
----------------------
E
F
D
-
E
D
A
--------
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
---
L
-----
T
V
H
D
A
L
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
57.56
19%
-57
- C1 -
-
2PSQ
-
B:
[78-363]
-----------------------------------------------------------------------
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
------
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
----
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
--
R
R
P
P
G
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
-----
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
-----
N
--------
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
YK
K
T
T
N
G
R
L
P
V
----
K
W
M
A
P
E
A
L
F
---
D
R
-
V
-------
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
--
P
G
I
--
P
V
E
E
L
F
K
L
L
K
E
G
H
---
R
---------------------
M
D
----
K
--------
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
---
P
-----
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
56.83
26%
-90
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-263]
--------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
----------
E
L
A
A
I
K
V
I
K
L
E
P
-----
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
-------
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
-----
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
-----
G
--------
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
-----
A
F
I
G
T
P
----
Y
W
M
A
P
E
V
A
A
V
ER
K
G
-
G
-------
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
-
Q
P
P
M
--
F
D
L
H
P
--
M
R
A
L
F
L
M
T
K
S
N
--
F
Q
---------------------
P
P
-
K
L
K
D
--------
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
---
P
-----
T
A
E
K
L
L
Q
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
55.40
21%
16
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
--
T
G
R
--------
V
F
V
A
K
F
I
N
T
P
-----
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
-----
A
A
E
-
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
-----
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
---
S
--------
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
---
V
K
V
T
T
A
T
A
----
E
F
A
A
P
E
I
V
D
---
R
E
-
P
-------
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
-
L
S
P
F
--
A
G
E
--
D
D
L
E
T
L
Q
N
V
K
R
C
D
--
W
E
---------------------
F
D
E
D
A
F
S
--------
S
--
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
---
L
-----
T
V
H
D
A
L
---------------------------------------
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
------
I
R
Q
K
I
K
E
K
Y
A
D
---
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
-------------
E
Y
-------------------------------------
Q
I
Y
D
S
Y
F
D
R
K
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
55.21
23%
-127
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-275]
------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
----------
K
T
Y
M
A
K
F
V
K
V
K
G
------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
--
S
----
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-----
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
---
S
S
--------
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-
D
--
N
F
R
L
L
F
T
A
P
----
E
Y
Y
A
P
E
V
H
Q
---
H
D
-
V
-------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
-
I
N
P
F
--
L
A
E
T
--
N
Q
Q
I
I
E
N
I
M
N
A
E
--
Y
T
-----------------------
F
D
E
E
A
--------
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
---
M
-----
T
A
S
E
A
L
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
53.67
35%
-137
- C1 -
-
2W5A
3
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
--
F
A
K
T
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
M
---------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
53.64
19%
-15
- C1 -
-
2PZI
5
PKNG_MYCTU
A:
[1-677]
GSHMLGGGL
V
E
I
P
R
A
PDIDPLEALMT
N
P
V
V
P
ESKRFCWNCGRPVGRSGAS
E
G
W
C
PYCG
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
N
G
R
---------
P
V
V
L
K
G
L
V
H
S
G
----
D
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
-
V
-
H
P
S
I
V
Q
-
I
F
N
F
V
E
H
T
D
R
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
L
K
Q
-------------
K
L
P
V
A
E
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
-----
L
V
Y
N
D
L
K
P
E
N
I
M
L
T
------
E
E
--------
Q
L
K
L
I
D
L
G
A
V
S
R
I
N
S
F
------
G
Y
L
Y
G
T
P
----
G
F
Q
A
P
E
I
V
R
---
T
G
-
P
--------
T
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
-
D
-
L
P
T
R
----------------
N
G
R
Y
--
V
D
---------------------
G
L
P
E
D
D
P
--------
V
L
K
T
Y
D
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
---
F
-----
T
T
A
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
------
A
Q
D
T
G
V
P
R
P
------
G
L
S
T
I
F
S
P
S
R
S
T
F
G
V
D
L
L
V
A
H
T
D
V
Y
L
D
G
Q
VHAEKL
T
A
N
E
I
V
T
A
L
S
V
---
P
L
V
D
P
T
D
V
A
A
S
V
L
Q
A
T
V
L
S
Q
P
V
Q
-------------
T
L
D
S
L
R
A
A
R
H
G
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
-
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
GD
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
PGE
L
A
P
K
L
A
L
A
A
T
A
E
L
A
GNTDEHK
F
Y
Q
T
V
W
S
T
NDGV
I
S
A
A
F
G
L
A
R
A
R
S
A
E
GD
R
V
G
A
V
R
T
L
D
E
VPPTSRH
F
T
T
A
R
L
T
S
A
V
T
L
LVT
E
E
Q
I
R
D
A
A
R
R
V
E
A
LPPTEPR
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
KASTNHILGFPFT
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
APT
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
RP
41
HHSearch
53.33
23%
-107
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[53-337]
-------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
----------
E
L
V
A
I
K
K
V
L
Q
D
---------
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
-
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
---
Y
S
R
A
-
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
-----
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
----
A
--------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
---
P
N
V
S
Y
I
C
S
R
----
Y
Y
R
A
P
E
L
I
F
---
G
A
T
D
-------
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
-
Q
P
I
F
--
P
G
D
S
G
--
V
D
Q
L
V
E
I
I
K
V
L
GT
P
T
R
E
Q
I
R
E
M
NPNYTEFKFPQIKA
H
P
W
T
K
V
F
--------
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
---
L
-----
T
P
L
E
A
C
A
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
51.97
25%
-57
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-287]
----------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
----------
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
A
D
A
-
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
--
N
S
A
--------
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
--
V
A
G
G
R
V
G
T
P
----
H
F
M
A
P
E
V
V
K
---
R
E
-
P
-------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
-
C
L
P
F
--
Y
G
T
K
---
E
R
L
F
E
G
I
I
K
G
K
--
Y
K
---------------------
M
N
P
R
--
Q
--------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
---
I
-----
T
V
Y
E
A
L
N
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
51.44
22%
-131
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-343]
--------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
----------
L
K
L
A
A
K
I
I
K
T
R
G
-----
M
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
--
E
----
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
-----
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
---
A
K
--------
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
---
K
L
K
V
N
F
G
T
P
----
E
F
L
A
P
E
V
V
N
---
Y
D
-
F
-------
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
-
L
S
P
F
--
L
G
D
N
--
D
A
E
T
L
N
N
I
L
A
C
R
--
W
D
---------------------
L
E
D
--
E
E
--------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
---
I
-----
S
A
S
E
A
L
K
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.61
35%
-151
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
-----------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
--
S
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
47.84
35%
-130
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D---------
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
----------------
T
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
M
-
S
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.68
35%
-134
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
M
----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
47.52
35%
-140
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
------------------
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.38
35%
-136
- C1 -
-
2XNP
4
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-------
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.16
35%
-133
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
-------------------
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.62
35%
-145
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----------
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
--------------------
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.07
35%
-136
- C1 -
-
2XNO
9
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
-----------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.84
35%
-136
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
-----------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.52
35%
-103
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
DG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
------------------
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
M
-
S
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
45.52
35%
-132
- C1 -
-
2XNM
6
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
---------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
L
A
R
I
L
-----------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
--
S
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.49
35%
-127
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D---------
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
--------------------
T
P
----
Y
Y
M
S
P
E
Q
M
N
---------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.18
35%
-133
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
-----------------
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.75
35%
-139
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----------
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
--------------------
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
43.23
35%
-126
- C1 -
-
2XNN
4
NEK2_HUMAN
A:
[35-216]
-----------------------------------------------------------------------------------------------------------------
V
W
K
E
L
D
Y
G
S
M
---
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
----
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
-------------
V
K
L
G
D
F
G
----------------
F
V
G
T
P
----
Y
Y
M
S
P
E
Q
M
N
---
R
----------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
-
L
-
M
P
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------