@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKM5: (2017-10-27 )
MQIGIPTETVVGENRVAATPETVKKLISAGHSVVIERGAGVKAAYIDSAYEQVGATITDDAYTGSQIILKVRAPQGGEIQKLAANTTVVAMFDPYRNTELDQFANQQVSAFALELLPRTLSRAQNMDVLSSQANLAGYKSVLLAAAEYQRMFPMLMTAAGTVKPARVVIMGVGVAGLQAVATAKRLGAIVEATDLRPTAKDQVESLGGKWLDVPMSEEEQQRAADAAKNGYGWMPGEQYIKDQAAIVDKAVSNADIVITTALLPGRDAPRLIKAETVAKMKPGSVILDMAVETGGNVEGSKVGETVVTENGVKILGIPNIPATVATEASALYARNVFNFVETLFDKEKNFAINQEDEIQKALLVTHGGQVLLKRG
Atome Classification :
(39 SA)
.........10........20........30........40........50......--..---60-.-........70.....-----..-----.80........90......-..-100.-.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......-310.......320.......330.......340..-...-..350-........360-.......370...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQIGIPTETVVGENRVAA
T
P
E
T
V
K
K
L
I
SAG
H
S
V
V
I
ERGAG
V
K
A
A
Y
I
D
S
A
Y
E
Q
VG
A
T
I--TD---D--A-YTG
S
Q
I
I
L
K
V
RAPQG-----G
E
-----
I
Q
K
LAAN
T
T
V
V
A
M
FDPYRN-T
E
-
L
-
D
Q
-
F
A
N
Q
Q
V
S
A
F
A
L
E
L
L
P
R
T
L
S
R
AQN
M
D
V
L
S
SQAN
L
A
G
Y
K
S
V
L
L
A
A
A
E
Y
Q
R
M
F
P
M
L
M
TAAGTVK
P
A
R
V
V
I
M
GV
G
V
A
G
L
Q
A
V
A
T
A
K
R
L
G
A
I
V
E
ATDLRPT
A
K
D
Q
V
E
S
LGG
K
W
LDVPM
S
E
E
E
Q
Q
R
A
A
D
AAKNGYGWM
P
G
E
Q
Y
I
K
D
Q
A
A
I
V
D
KAVSNA
D
I
V
I
T
T
ALLPGRDAP
R
L
I
K
A
E
T
V
AKMKPG
S
V
I
L
D
M
A
VETGGNVEGSKVG
E
T
V
VTE-N
G
V
K
I
L
GIPNIP
A
T
V
A
T
E
A
S
A
L
Y
A
R
N
V
F
N
F
V
E
T
L
F-DKE-KNFA--IN
Q
E
D
E
I
Q
K
A
L
-
L
VTHG
G
Q
V
L
L
KRG
12
PsiBlast_PDB
78.12
49%
-32
- C2 -
-
4DIO
-
?
A:
[36-399]
----
I
A
K
E
S
D
P
N
E
G
R
V
A
G
S
V
E
S
V
K
K
L
K
S
L
G
F
D
V
V
V
E
A
G
A
G
L
G
S
R
I
P
D
Q
E
Y
E
K
A
G
A
R
V
G
T
A
A
---
D
--
A
-
K
T
-
A
D
V
I
L
K
V
R
R
P
S
A
-----
Q
E
-----
I
S
G
Y
R
S
G
A
V
V
I
A
I
M
D
P
Y
G
N
-
E
E
A
I
-
S
A
-
M
A
G
A
G
L
T
T
F
A
M
E
L
M
P
R
-
I
T
R
A
Q
S
M
D
V
L
S
S
Q
A
N
L
A
G
Y
Q
A
V
I
D
A
A
Y
E
Y
D
R
A
L
P
M
M
M
T
A
A
G
T
V
P
A
A
K
I
F
V
M
G
A
G
V
A
G
L
Q
A
I
A
T
A
R
R
L
G
A
V
V
S
A
T
D
V
R
P
A
A
K
E
Q
V
A
S
L
G
A
K
F
I
A
V
---
E
D
------------------
G
E
Y
Q
V
K
Q
A
A
L
V
A
E
H
I
A
K
Q
D
I
V
I
T
T
A
L
I
P
G
R
P
A
P
R
L
V
T
R
E
M
L
D
S
M
K
P
G
S
V
V
V
D
L
A
V
E
R
G
G
N
I
E
G
A
E
A
G
K
--
V
T
E
V
G
G
V
R
I
V
G
H
L
N
V
A
G
R
I
A
A
S
A
S
L
L
Y
A
K
N
L
V
T
F
L
E
T
M
V
------
A
L
A
--
L
N
M
E
D
E
L
V
K
A
T
-
A
L
T
H
G
G
A
V
V
----
73
HHSearch
77.19
45%
-42
- C2 -
-
3P2Y
2
?
A:
[23-377]
T
L
I
G
V
P
R
E
S
A
E
G
E
R
R
V
A
L
V
P
K
V
V
E
K
L
S
A
R
G
L
E
V
V
V
E
S
A
A
G
A
G
A
L
F
S
D
A
D
Y
E
R
A
G
A
T
I
--
G
D
--------
P
W
P
A
D
V
V
V
K
V
N
P
P
T
S
-----
D
E
-----
I
S
Q
L
K
P
G
S
V
L
I
G
F
L
A
P
R
T
Q
P
E
L
-
A
-
S
R
-
L
R
I
A
D
V
T
A
F
A
M
E
S
I
P
R
-
I
S
R
A
Q
T
M
D
A
L
S
S
Q
A
N
V
A
G
Y
K
A
V
L
L
G
A
S
L
S
T
R
F
V
P
M
L
T
T
A
A
G
T
V
K
P
A
S
A
L
V
L
G
V
G
V
A
G
L
Q
A
L
A
T
A
K
R
L
G
A
K
T
T
G
Y
D
V
R
P
E
V
A
E
Q
V
R
S
V
G
A
Q
W
L
D
L
G
---------------------
S
E
A
E
R
A
Q
Q
Q
Q
A
L
E
D
A
I
T
K
F
D
I
V
I
T
T
A
L
V
P
G
R
P
A
P
R
L
V
T
A
A
A
A
T
G
M
Q
P
G
S
V
V
V
D
L
A
G
E
T
G
G
N
C
E
L
T
E
P
G
R
T
I
-
V
H
-
H
G
V
T
I
T
S
P
L
N
L
P
A
T
M
P
E
H
A
S
E
L
Y
A
K
N
V
T
A
L
L
D
L
L
L
-
T
D
--
D
G
V
A
--
P
D
F
T
D
E
I
V
A
A
S
-
C
I
T
R
T
--------
40
PsiBlast_CBE
76.70
41%
-27
- C2 -
-
1X14
1
PNTA_ECOLI
B:
[9-373]
-
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
--
V
E
G
--
N
--
S
-
V
W
Q
S
E
I
I
L
K
V
N
A
P
L
D
-----
D
E
-----
I
A
L
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
-
P
E
-
L
-
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
-
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
--------------------
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
-
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
K
E
K
D
-
G
N
I
T
--
V
D
F
D
D
V
V
I
R
G
V
-
T
V
I
R
A
G
E
I
-----
78
HHSearch
76.37
47%
-34
- C2 -
-
4DIO
-
?
A:
[32-399]
E
I
V
F
I
A
K
E
S
D
P
N
E
G
R
V
A
G
S
V
E
S
V
K
K
L
K
S
L
G
F
D
V
V
V
E
A
G
A
G
L
G
S
R
I
P
D
Q
E
Y
E
K
A
G
A
R
V
--
G
T
---
A
--
A
D
A
K
T
A
D
V
I
L
K
V
R
R
P
S
A
-----
Q
E
-----
I
S
G
Y
R
S
G
A
V
V
I
A
I
M
D
P
Y
G
N
E
E
A
-
I
-
S
A
-
M
A
G
A
G
L
T
T
F
A
M
E
L
M
P
R
-
I
T
R
A
Q
S
M
D
V
L
S
S
Q
A
N
L
A
G
Y
Q
A
V
I
D
A
A
Y
E
Y
D
R
A
L
P
M
M
M
T
A
A
G
T
V
P
A
A
K
I
F
V
M
G
A
G
V
A
G
L
Q
A
I
A
T
A
R
R
L
G
A
V
V
S
A
T
D
V
R
P
A
A
K
E
Q
V
A
S
L
G
A
K
F
I
A
V
E
D
---------------------
G
E
Y
Q
V
K
Q
A
A
L
V
A
E
H
I
A
K
Q
D
I
V
I
T
T
A
L
I
P
G
R
P
A
P
R
L
V
T
R
E
M
L
D
S
M
K
P
G
S
V
V
V
D
L
A
V
E
R
G
G
N
I
E
G
A
E
A
G
-
K
V
T
E
V
-
G
G
V
R
I
V
G
H
L
N
V
A
G
R
I
A
A
S
A
S
L
L
Y
A
K
N
L
V
T
F
L
E
T
M
V
--------
A
L
-
A
L
N
M
E
D
E
L
V
K
A
T
A
L
T
H
G
G
A
V
V
----
7
PsiBlast_PDB
76.36
46%
9
- C2 -
-
1U2G
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
18
PsiBlast_PDB
76.25
41%
-23
- C2 -
-
1X14
-
PNTA_ECOLI
A:
[9-373]
-
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
--
V
E
G
--
N
--
S
-
V
W
Q
S
E
I
I
L
K
V
N
A
P
L
D
-----
D
E
-----
I
A
L
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
-
P
E
-
L
-
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
-
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
F
-------------
D
G
Y
A
K
V
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
-
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
K
E
K
D
-
G
N
I
T
--
V
D
F
D
D
V
V
I
R
G
V
-
T
V
I
R
A
G
E
I
-----
13
PsiBlast_PDB
76.17
46%
2
- C2 -
-
2FSV
2
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
----------------
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
9
PsiBlast_PDB
76.14
46%
7
- C2 -
-
2OO5
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
79
HHSearch
76.09
47%
13
- C2 -
-
1F8G
1
PNTAA_RHORT
A:
[1-378]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
---
T
A
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
AEEGT
D
E
-----
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
-
V
-
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
D
D
E
A
------
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
-
V
V
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
--
D
T
K
T
LV
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
H
P
A
-
80
HHSearch
75.52
47%
3
* C2 *
-
1L7D
-
PNTAA_RHORT
A:
[1-377]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
---
T
A
A
Q
A
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
AEEGT
D
E
-----
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
-
V
-
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---------------------------
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
-
V
V
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
--
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
H
P
--
75
HHSearch
75.46
41%
-21
- C2 -
-
1X13
-
B:
[1002-1370]
-
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
--
V
E
---
G
--
N
S
V
W
Q
S
E
I
I
L
K
V
N
A
P
L
D
-----
D
E
-----
I
A
L
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
P
E
L
-
M
-
Q
K
-
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
-
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
---------------------
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
-
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
-
K
E
K
D
G
N
I
T
--
V
D
F
D
D
V
V
I
R
G
V
-
T
V
I
R
A
G
E
I
T
W
P
A
-
3
PsiBlast_PDB
75.43
46%
1
- C2 -
-
1L7D
-
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---------------------------
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
32
PsiBlast_CBE
75.01
46%
5
- C2 -
-
1L7E
1
PNTAA_RHORT
D:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
-----------
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
15
PsiBlast_PDB
75.00
46%
-1
- C2 -
-
2FR8
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
-
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
-----------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
34
PsiBlast_CBE
74.94
46%
4
- C2 -
-
2FRD
2
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
TAA
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
-------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
35
PsiBlast_CBE
74.90
46%
-0
- C2 -
-
2FSV
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
--------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
23
PsiBlast_CBE
74.87
46%
7
- C2 -
-
2OO5
2
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
TAA
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
31
PsiBlast_CBE
74.81
46%
-3
- C2 -
-
1U28
4
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
----------------------
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
-
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
4
PsiBlast_PDB
74.81
46%
7
- C2 -
-
1L7E
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
------
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
39
PsiBlast_CBE
74.78
41%
-25
- C2 -
-
1X15
1
PNTA_ECOLI
B:
[9-373]
-
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
--
V
E
G
--
N
--
S
-
V
W
Q
S
E
I
I
L
K
V
N
A
P
L
D
-----
D
E
-----
I
A
L
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
-
P
E
-
L
-
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
-
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
---------------------
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
-
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
K
E
K
D
-
G
N
I
T
--
V
D
F
D
D
V
V
I
R
G
V
-
T
V
I
R
A
G
E
I
-----
10
PsiBlast_PDB
74.65
46%
9
- C2 -
-
2OOR
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
37
PsiBlast_CBE
74.51
46%
1
- C2 -
-
2FR8
1
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
TAA
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
-
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
----------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
33
PsiBlast_CBE
74.50
46%
1
- C2 -
-
1HZZ
1
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
----------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
21
PsiBlast_CBE
74.39
46%
3
- C2 -
-
1PTJ
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
----------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
14
PsiBlast_PDB
74.23
46%
3
- C2 -
-
1NM5
1
PNTAA_RHORT
A:
[1-374]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
------------------
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
-----
29
PsiBlast_CBE
74.08
46%
-0
- C2 -
-
1U2G
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
--------------------------
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
22
PsiBlast_CBE
74.05
46%
3
- C2 -
-
2OOR
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
------------------
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
2
PsiBlast_PDB
73.59
46%
-0
- C2 -
-
1HZZ
1
PNTAA_RHORT
A:
[1-371]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
TAA
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
---------
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
--------
36
PsiBlast_CBE
73.34
46%
4
- C2 -
-
1NM5
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
------------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
6
PsiBlast_PDB
73.31
46%
9
- C2 -
-
1U2D
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
5
PsiBlast_PDB
73.27
46%
10
- C2 -
-
1U28
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
30
PsiBlast_CBE
73.26
46%
7
- C2 -
-
1U2D
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
TAA
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
D
G
A
I
V
----
50
PsiBlast_CBE
72.77
41%
-27
- C2 -
-
4IZI
2
?
B:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
--
V
E
RG-
E
--
L
-
L
K
G
A
H
L
L
F
T
V
Q
P
P
P
E
-----
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
-
L
E
-
L
-
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
-
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
S
A
E
---------------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
-
P
G
E
V
V
E
V
-
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
-
E
K
--
G
A
F
A
--
P
K
W
E
D
E
I
V
R
A
A
-
L
L
M
K
E
G
E
V
L
----
51
PsiBlast_CBE
72.63
41%
-26
- C2 -
-
4IZI
5
?
A:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
--
V
E
RG-
E
--
L
-
L
K
G
A
H
L
L
F
T
V
Q
P
P
P
E
-----
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
-
L
E
-
L
-
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
-
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
S
A
E
---------------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
-
P
G
E
V
V
E
V
-
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
-
E
K
--
G
A
F
A
--
P
K
W
E
D
E
I
V
R
A
A
-
L
L
M
K
E
G
E
V
L
----
52
PsiBlast_CBE
72.05
41%
-31
- C2 -
-
4IZH
8
?
B:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
--
V
E
RG-
E
--
L
-
L
K
G
A
H
L
L
F
T
V
Q
P
P
P
E
-----
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
-
L
E
-
L
-
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
-
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
S
-----------------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
-
P
G
E
V
V
E
V
-
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
-
E
K
--
G
A
F
A
--
P
K
W
E
D
E
I
V
R
A
A
-
L
L
M
K
E
G
E
V
L
----
48
PsiBlast_CBE
71.96
41%
-27
- C2 -
-
4J16
3
?
B:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
--
V
E
RG-
E
--
L
-
L
K
G
A
H
L
L
F
T
V
Q
P
P
P
E
-----
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
-
L
E
-
L
-
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
-
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
S
A
E
--------
G
----
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
-
P
G
E
V
V
E
V
-
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
-
E
K
--
G
A
F
A
--
P
K
W
E
D
E
I
V
R
A
A
-
L
L
M
K
E
G
E
V
L
----
49
PsiBlast_CBE
71.73
41%
-24
- C2 -
-
4J16
3
?
A:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
--
V
E
RG-
E
--
L
-
L
K
G
A
H
L
L
F
T
V
Q
P
P
P
E
-----
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
-
L
E
-
L
-
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
-
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
S
A
E
--------
G
E
G
G
Y
A
R
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
-
P
G
E
V
V
E
V
-
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
S
L
L
I
-
E
K
--
G
A
F
A
--
P
K
W
E
D
E
I
V
R
A
A
-
L
L
M
K
E
G
E
V
L
----
11
PsiBlast_PDB
71.11
46%
10
- C2 -
-
2FRD
1
PNTAA_RHORT
A:
[1-370]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
--
A
S
T
A
A
Q
--
A
-
L
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
-----
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
-
R
P
-
V
V
E
A
-
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
-
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
-------------
A
-
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
-
K
-
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
T
P
H
V
-
D
K
D
T
K
T
L
V
--
M
K
L
E
D
E
T
V
S
G
T
-
C
V
T
R
---------
38
PsiBlast_CBE
70.43
41%
-24
- C2 -
-
2BRU
2
PNTA_ECOLI
B:
[9-373]
-
R
I
G
I
P
R
E
R
L
T
N
E
T
R
V
A
A
T
P
K
T
V
E
Q
L
L
K
L
G
F
T
V
A
V
E
S
G
A
G
Q
L
A
S
F
D
D
K
A
F
V
Q
A
G
A
E
I
--
V
E
G--
N
--
S
-
V
W
Q
S
E
I
I
L
K
V
N
A
P
L
D
-----
D
E
-----
I
A
L
L
N
P
G
T
T
L
V
S
F
I
W
P
A
Q
N
-
P
E
-
L
-
M
Q
K
L
A
E
R
N
V
T
V
M
A
M
D
S
V
P
R
-
I
S
R
A
Q
S
L
D
A
L
S
S
M
A
N
I
A
G
Y
R
A
I
V
E
A
A
H
E
F
G
R
F
F
T
G
Q
I
T
A
A
G
K
V
P
P
A
K
V
M
V
I
G
A
G
V
A
G
L
A
A
I
G
A
A
N
S
L
G
A
I
V
R
A
F
D
T
R
P
E
V
K
E
Q
V
Q
S
M
G
A
E
F
L
E
L
D
--------------------
M
S
D
A
F
I
K
A
E
M
E
L
F
A
A
Q
A
K
E
V
D
I
I
V
T
T
A
L
I
P
G
K
P
A
P
K
L
I
T
R
E
M
V
D
S
M
K
A
G
S
V
I
V
D
L
A
A
Q
N
G
G
N
C
E
Y
T
V
P
G
E
I
F
T
T
E
-
N
G
V
K
V
I
G
Y
T
D
L
P
G
R
L
P
T
Q
S
S
Q
L
Y
G
T
N
L
V
N
L
L
K
L
L
C
K
E
K
D
-
G
N
I
T
--
V
D
F
D
D
V
V
I
R
G
V
-
T
V
I
R
A
G
E
I
-----