@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKM9: (2017-10-27 )
MGLSVMQSLQSLQPRISVAPMMDWTTKDYRFFARLFNPNVVLYTEMVTTGAILFGDAKRHLDYNAQEHPIVLQLGGSNPQELATCTKMAEDWGYDEVNLNVGCPSDRVQNNKIGACLMAEPDLVAECIHSMQKAVNIPVTVKHRIGIDDMQSYEEMLHFVDTVAATGCTHFVVHARIAILKGLSPKENREVPPLRYEDVYRLKQERPHLTIEINGGIKTFAETQAHLQHVDGVMIGREAYHNPYLLAELGQLWNLEAPDRFDIMEQMLPYIEQRLAEGAPLSIITRHILGLFQNLPGARKWRQALSGGNAKTLTDVENAIHNMQAAIIRTEEYLKEHQF
Atome Classification :
(23 SA)
.........10........20....--------.....30.....-....40....-....50.----.----..---------.------.---------.-.----------60-----..--...------------.---...----70......------------------------..------------80........90........100---------.---------......110.......120.......130...--....140.......--150.......160.......170.......--------180.......190.......200.......210....----...220..--.--..-.--.--230.........240.......250-..---.---.----.-.-..260..---.....270.....-..280...-.-...290.......300...-....310...-....320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
G
L
S
V
M
Q
S
L
Q
SLQPRISVAP-MMDW--------TT
K
D
Y
R
-
F
F
A
R
L-FNP
N
V
V
L
Y
T
E
-MVTT
G
A
I
----
L
----FG---------D------
A
---------
K
-
R
----------H------LD--YNA------------Q---EH
P
----
I
V
L
Q
LGGS------------------------
N
P
------------
Q
E
L
A
T
C
T
K
M
A
E
DWGY
D
E
V
N
L
NVG---------C---------PSDRVQNNKI
G
A
C
L
MAE
P
D
L
V
A
E
C
I
H
S
M
Q
K
AV--NI
P
V
T
V
K
H
RIG
I
D
D
--
M
Q
S
Y
E
E
M
L
H
F
V
D
T
V
A
ATG
C
T
H
F
V
V
H
A
R
I
A
I
--------LKGLSPKENREVPPL
R
Y
E
D
V
Y
R
L
K
QERP
H
L
T
I
E
INGG----
I
K
T
F
A
E
T
Q
--
A
--
H
L
-
Q
--H--V--D
G
V
M
I
G
R
E
AYHN
P
Y
L
L
A
E
L
G
-
Q
-LW---N---L----E-A-P
D
R
F
D
I
M
---
E
Q
M
L
P
Y
I
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Q
R
L
AE-GA
P
L
S
I
I
T
-
R
-
H
I
L
G
L
F
QNLP
G
A
R
K
W
R
Q
A
L-SGGNAK
T
L
T
D
-
V
E
N
A
I
H
N
M
Q
A
A
I
I
R
T
E
E
Y
L
K
EHQF
2
PsiBlast_PDB
94.86
42%
-85
- C3 -
-
3B0U
3
DUSAL_THET8
X:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------
L
-
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
-
V
F
---
G
---
L
P---
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
--
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
----------------
21
PsiBlast_CBE
93.36
42%
-83
- C3 -
-
3B0U
2
DUSAL_THET8
Y:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------
L
-
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
-
V
F
---
G
---
L
P---
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
--
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
----------------
1
PsiBlast_PDB
92.77
42%
-90
- C3 -
-
3B0P
1
DUSAL_THET8
A:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
-------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
-
V
F
---
G
---
L
P---
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
--
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
----------------
30
Fugue
92.14
41%
-84
- C3 -
-
3B0P
1
DUSAL_THET8
A:
[2-318]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
-------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
-
R
-
R
V
FG-
L
---
P
----
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
--
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
E
E
V
G
E
----------
22
PsiBlast_CBE
91.98
42%
-87
- C3 -
-
3B0P
1
DUSAL_THET8
B:
[2-312]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
-------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
-
V
F
---
G
---
L
P---
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
--
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
----------------
3
PsiBlast_PDB
91.67
40%
-82
- C3 -
-
3B0V
1
DUSAL_THET8
C:
[22-331]
----------
M
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
--
F
R
P
------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------
L
-
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
-
V
F
---
G
---
L
P---
R
-
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
--
R
S
L
Q
A
-
L
D
R
A
L
R
------------------
41
HHSearch
90.59
43%
-30
- C3 -
-
3B0U
2
DUSAL_THET8
Y:
[2-313]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
F-
R
P
-------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------
L
-
A
L
S
T
K
A
N
R
E
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
-
R
R
V
F
---
G
---
L
----
P
R
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
--
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
---------------
40
HHSearch
88.70
43%
-35
- C3 -
-
3B0P
1
DUSAL_THET8
A:
[2-318]
-----------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
R
H
F
R
-
F
L
V
R
Q
-
V
S
L
G
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
----
L
----
R
G
---------
N
------
R
---------
E
-
R
----------
L
------
L
A
F-
R
P
-------------
E
---
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
P
------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
-------------------
I
P
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
--
F
--
H
L
-
K
--
R
--
V
--
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
-
R
R
V
F
---
G
---
L
----
P
R
R
-
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
-
G
T
P
P
W
A
V
L
-
R
-
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
--
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
E
E
V
G
E
----------
32
Fugue
62.56
24%
14
- C3 -
-
4BFA
4
DUSC_ECOLI
A:
[22-338]
-----------
A
S
M
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
S
L
V
R
E
L
L
T
E
V
-
N
D
Y
D
L
C
I
T
E
F
-
V
R
V
V
D
Q
L
----
L
P
V
K
V
F
H
---------
R
------
I
---------
C
-
P
----------
E
------
L
Q
--
N
A
S
------------
R
TPS
G
T
L
----
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
-----
S
G
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
---------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
-
L
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
--
Q
--
C
M
-
A
--
I
S
G
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
-
Y
-
N
E
P--
R
---
M
----
P
-
W
-
P
E
V
V
A
L
L
---
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
-
L
Y
H
V
A
R
I
K
-
Q
-
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
--
V
L
N
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
I
E
K
L
-----------
42
HHSearch
61.21
20%
12
- C3 -
-
1VHN
1
?
A:
[5-309]
-------------
V
K
V
G
L
A
P
-
M
A
G
Y
--------
T
D
S
A
F
R
-
T
L
A
F
E
-
W
G
-
A
D
F
A
F
S
E
-
M
V
S
A
K
G
F
----
L
----
M
N
---------
S
------
Q
K
T
-------
E
-
E
----------
L
------
L
P
--
Q
P
-------------
H
---
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
P
------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
Y
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
------
N
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
V
V
--------
Q
-------
S
F
-
T
G
R
A
E
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
V
S
G
D
----
I
F
T
P
E
D
A
K
--
R
--
A
L
E
E
S
-
G
--
C
--
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
-
D
F
L
R
---
S
---
G
K
Y
S
E
P
-
S
R
E
E
I
L
R
T
F
---
E
R
H
L
E
L
L
I
K
T
K
G
E
-
R
K
A
V
V
E
M
R
-
K
-
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
--
E
V
Q
I
-
L
K
E
M
F
Y
N
F
I
K
E
V
E
-----------
45
HHSearch
60.69
21%
-27
- C3 -
-
4WFS
1
DUS2L_HUMAN
A:
[7-308]
--------------
H
L
I
L
A
P
-
M
V
R
V
--------
G
T
L
P
M
R
-
L
L
A
L
D
-
Y
-
G
A
D
I
V
Y
C
E
-
E
L
I
D
L
K
M
----
I
----
Q
C
K
R
V
V
N
E---
V
------
L
---------
S
-
T
V
D
F
V
A
PDDRV
V
------
F
R
T
-
C
E
R
------------
E
---
Q
N
R
----
V
V
F
Q
M
G
T
S
------------------------
D
A
------------
E
R
A
L
A
V
A
R
L
V
E
-
N
D
V
A
G
I
D
V
N
M
G
-------------------------------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
T
--
R
R
P
V
T
C
K
I
R
I
L
P
S
L
------
E
D
T
L
S
L
V
K
R
I
E
R
T
G
I
A
A
I
A
V
H
G
R
K
R
E
---------------
E
-
R
P
Q
H
P
V
S
C
E
V
I
K
A
I
A
D
T
L
-
S
I
P
V
I
A
N
G
G
SHDH
I
Q
Q
Y
S
D
I
E
--
D
--
F
R
-
Q
A
T
A
--
A
--
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
L
K
E
G
-
L
-------------------
R
P
L
E
E
V
M
---
Q
K
Y
I
R
Y
A
V
Q
Y
D
N
----
H
Y
T
N
T
K
-
Y
-
C
L
C
Q
M
L
R
E
Q
L
E
-
S
P
Q
G
R
L
L
-
H
A
A
Q
--
S
S
R
E
-
I
C
E
A
F
-------------------
46
HHSearch
60.12
20%
-30
- C3 -
-
4XP7
1
DUS2L_HUMAN
A:
[13-320]
--------
S
L
C
Y
H
N
K
L
I
L
A
P
-
M
V
R
V
--------
G
T
L
P
M
R
-
L
L
A
L
D
-
Y
-
G
A
D
I
V
Y
C
E
-
E
L
I
D
L
K
M
----
I
----
Q
C
---------
K
R
VVNEV
L
STVDFVAPD
D
-
R
V---------
V
------
F
R
T
-
C
E
R
------------
E
---
Q
N
R
----
V
V
F
Q
M
G
T
S
------------------------
D
A
------------
E
R
A
L
A
V
A
R
L
V
E
-
N
D
V
A
G
I
D
V
N
M
G
---------
C
---------
P
K
Q
---------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
T
--
R
R
P
V
T
C
K
I
R
I
L
P
S
L
------
E
D
T
L
S
L
V
K
R
I
E
R
T
G
I
A
A
I
A
V
H
G
R
K
R
E
--------
E
--------
R
P
Q
H
P
V
S
C
E
V
I
K
A
I
A
D
T
L
-
S
I
P
V
I
A
N
G
G
SHDH
I
Q
Q
Y
S
D
I
E
--
D
--
F
R
-
Q
A
T
A
--
A
--
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
L
K
E
G
-
L
-------------------
R
P
L
E
E
V
M
---
Q
K
Y
I
R
Y
A
V
Q
Y
D
N
----
H
Y
T
N
T
K
-
Y
-
C
L
C
Q
M
L
R
E
Q
L
E
S
-
P
Q
G
R
L
L
-
H
A
A
Q
--
S
S
R
E
-
I
C
E
A
F
-------------------
43
HHSearch
60.10
25%
18
- C3 -
-
4BFA
4
DUSC_ECOLI
A:
[22-335]
-----------
A
S
M
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
S
L
V
R
-
E
L
L
T
E
-
V
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
Q
----
L
----
L
P
---------
V
------
K
V
F
-------
H
-
R
----------
I
C
PELQN
A
S
R-
T
P
-------------
S
---
G
T
L
----
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
---
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
E
---------------
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
--
Q
--
C
M
-
A
I
S
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
-
Y
N
E
P
---
R
---
M
----
P
-
W
-
P
E
V
V
A
L
L
---
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
-
L
Y
H
V
A
R
I
K
-
Q
-
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
--
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
I
--------------
44
HHSearch
59.55
25%
11
- C3 -
-
4YCO
1
DUSC_ECOLI
C:
[6-318]
------------
S
M
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
S
L
V
R
-
E
L
L
T
E
-
V
N
D
Y
D
L
C
I
T
E
-
F
V
R
V
V
D
Q
----
L
----
L
P
---------
V
------
K
VF-------
H
-
R
----------
I
CPELQN
A
S
R-
T
P
-------------
S
---
G
T
L
----
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
S
--
G
---
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
E
---------------
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
--
Q
--
C
M
-
A
IS
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
-
Y
N
E
P
---
R
---
M
----
P
-
W
-
P
E
V
V
A
L
L
---
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
-
L
Y
H
V
A
R
I
K
-
Q
-
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
--
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
I
--------------
31
Fugue
58.44
20%
20
- C3 -
-
1VHN
1
?
A:
[5-309]
-------------
V
K
V
G
L
A
P
M
A
-
G
Y
--------
T
D
S
A
F
R
-
T
L
A
F
E
-
W
G
A
D
F
-
A
F
S
E
M
V
S
A
K
G
F
-----
L
M
---
N
S
---------
Q
------
K
---------
T
-
E
----------
E
------
L
L
--
P
Q
P
------------
H
---
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
P
------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
Y
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
------
N
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
----------------
T
V
V
Q
S
F
T
G
R
A
E
W
K
A
L
S
V
L
E
K
R
I
P
---
T
F
V
S
G
D
----
I
F
T
P
E
D
A
K
--
R
--
A
L
-
E
--
E
S
G
C
--
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
-
D
-
F
L
---
R
SG
K
Y
----
S
-
E
-
P
S
R
E
E
I
L
---
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
E
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
---------------
9
PsiBlast_PDB
54.86
20%
-3
- C3 -
-
1VHN
1
?
A:
[5-288]
-------------
V
K
V
G
L
A
P
-
M
A
G
Y
--------
T
D
S
A
F
R
-
T
L
A
F
E
-
W
G
A
D
F
A
-
F
S
E
-
M
V
S
A
K
G
F
----
L
----
M
N
---------
S
------
Q
---------
K
T
E
----------
E
------
L
L
--
P
Q
P
------------
H
---
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
P
------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
Y
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
W
E
K
------
N
E
V
E
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
V
V
QSFTGRAE
W
K
A
L
S
V
L
E
K
R
-
I
P
T
F
V
S
G
D
I
F
--
T
P
E
D
A
K
R
A
L
E
E
S
G
---------------------------
C
--
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
-
D
-
F
L
R
SG
K
---
Y
----
S
-
E
-
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
-
R
K
A
V
V
E
M
R
-
K
-
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
------------------------------------
11
PsiBlast_PDB
52.78
23%
-7
- C3 -
-
4WFS
1
DUS2L_HUMAN
A:
[10-267]
-----------------
L
A
P
-
M
V
R
V
--------
G
T
L
P
M
R
-
L
L
A
L
D
-
Y
G
A
D
I
V
Y
C
E
E
-
L
I
D
L
K
M
I
Q
C
K
R
V
----
V
N
---------
E
------
V
---------
L
-
S
----------
T
------
V
D
--
F
V
A
PDDRVV
F
R
T
C
ER
E
---
Q
N
R
----
V
V
F
Q
M
G
T
S
------------------------
D
A
------------
E
R
A
L
A
V
A
R
L
V
E
N
-
D
V
A
G
I
D
V
N
M
G
-------------------------------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
T
--
R
R
P
V
T
C
K
I
R
I
------
L
P
S
L
E
D
T
L
S
L
V
K
R
I
E
R
T
G
I
A
A
I
A
V
H
G
R
----------------
K
R
E
E
R
P
Q
H
P
V
S
C
E
-
V
I
K
A
I
A
D
T
L
S
I
P
V
I
A
N
G
G
SHDH
I
Q
Q
Y
S
D
I
E
--
D
--
F
R
-
Q
--
A
--
T
AA
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
L
K
E
G
---
L
R
---
P
---
L
----
E
-------
E
V
M
---
Q
K
Y
I
R
Y
A
V
Q
-----------------------------------------------------------------------
10
PsiBlast_PDB
51.91
22%
7
- C3 -
-
4XP7
1
DUS2L_HUMAN
A:
[19-279]
--------------
K
L
I
L
A
P
-
M
V
R
V
--------
G
T
L
P
M
R
-
L
L
A
L
D
-
Y
G
A
D
I
V
Y
C
E
E
-
L
I
D
L
K
M
I
Q
C
K
R
V
----
V
N
---------
E
------
V
---------
L
-
S
----------
T
------
V
D
--
F
V
A
PDDRV
V
F
R
T
CER
E
---
Q
N
R
----
V
V
F
Q
M
G
T
S
------------------------
D
A
------------
E
R
A
L
A
V
A
R
L
V
E
N
-
D
V
A
G
I
D
V
N
M
G
---------
C
---------
P
K
Q
---------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
T
--
R
R
P
V
T
C
K
I
R
I
------
L
P
S
L
E
D
T
L
S
L
V
K
R
I
E
R
T
G
I
A
A
I
A
V
H
G
R
----------------
K
R
E
E
R
P
Q
H
P
V
S
C
E
-
V
I
K
A
I
A
D
T
L
S
I
P
V
I
A
N
G
G
SHDH
I
Q
Q
Y
S
D
I
E
--
D
--
F
R
-
Q
--
A
--
T
AA
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
L
K
E
G
---
L
R
---
P
---
L
----
E
-------
E
V
M
---
Q
K
Y
I
R
Y
A
V
Q
-----------------------------------------------------------------------
50
HHSearch
49.36
18%
-14
- C3 -
-
3KRZ
2
?
A:
[8-322]
----
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
-
M
C
M
Y
SASTDGMP
N
D
W
H
I
V
-
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
-
A
T
A
V
E
S
R
----
G
----
R
I
TDHDLGIWN
D
E
Q
V
K
E
-
L
---------
K
-
K
----------
I
------
V
D
I
C
K
A
-------------
N
---
G
A
V
----
M
G
I
Q
L
A
H
A
GRKCNISYEDVVGPSPIKAGDRYK
L
P
RELS
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
HGY
L
I
H
E
F
L
S
---------
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
PE
N
K
P
I
F
V
R
V
S
A
D
D
Y
M
EG
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
--------
N
V
-----
D
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
-
N
I
K
T
S
A
V
G
L
----
I
T
T
Q
E
L
A
E
--
E
--
I
L
-
S
N
-
E
R-
A
--
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
-
T
-------------------------------------------------------------------------------------------------------------
51
HHSearch
48.38
18%
-4
- C3 -
-
3KRU
1
?
D:
[9-322]
-----
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
-
M
C
M
Y
SASTDGMP
N
D
W
H
I
V
-
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
-
A
T
A
V
E
S
R
----
G
----
R
I
TDHDLGIWN
D
------
E
QVKEL----
K
-
K
----------
I
------
V
D
IC
K
A
-------------
N
---
G
A
V
----
M
G
I
Q
L
A
H
A
GRKCNISYEDVVGPSPIKAGDRYK
L
P
RELSVEEIKSIV
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
---------
H
GYLIHEFLS
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
PE
N
K
P
I
F
V
R
V
S
A
D
D
Y
M
EG
G
I
N
I
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
--------
N
V
D
-----
I
N
L
Y
P
G
Y
Q
V
K
Y
A
E
T
I
K
K
R
C
-
N
I
K
T
S
A
V
G
L
----
I
T
T
Q
E
L
A
E
--
E
--
I
L
-
S
N-
E
R-
A
--
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
-
T
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.12
31%
21
- C3 -
-
3W9Z
1
DUSC_ECOLI
A:
[55-244]
------------------------------------------------------------------------------------------------------------------------------
N
A
------------
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
C
----------------------
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
-----
S
G
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
---------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
-
R
L
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
--
Q
C
M
A
I
-
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
--------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.42
30%
34
- C3 -
-
4BF9
1
DUSC_ECOLI
A:
[78-256]
------------------------------------------------------------------------------------------------------------------------------
N
A
------------
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
-----
S
G
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
---------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
-
R
L
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
--
A
I
-
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.62
31%
34
- C3 -
-
4BFA
4
DUSC_ECOLI
A:
[78-256]
------------------------------------------------------------------------------------------------------------------------------
N
A
------------
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
P
------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
-----
S
G
E
K
K
F
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
---------------
T
K
E
Q
G
Y
R
A
E
H
I
D
W
Q
A
I
G
D
I
R
Q
-
R
L
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
--
Q
C
M
A
I
-
S
--
G
--
C
--
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
--------------------------------------------------------------------------------------------------------------------