@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKN8: (2017-10-27 )
MYFMSFKDELAAQVAQRRTFAIISHPDAGKTTMTEKLLLWGKAIQVAGMVKSRKSDRAATSDWMEMEKERGISITTSVMQFPYKGHTINLLDTPGHEDFSEDTYRTLTAVDSALMVIDGAKGVEERTIKLMEVCRMRDTPIISFVNKMDREIREPLELLDEIENVLNIRCVPITWPLGMGRDFAGVYNILEDKLYVYKAGFGSTITDIEVRDGYDHADIREKVGELAWASFEESLELVQMANEPLDRGLFLQGKQTPVLFGTALGNFGVDHVLDAFMHWAPEPKAHPTQERVVEAKEEGFSGFVFKIQANMDPKHRDRIAFMRICSGKYEKGLKMNHVRISKEVRISDALTFLAGEREHLEEAWPGDIIGLHNHGTIQIGDTFTSGENLHFTGIPHFAPEMFRRVRLKDPLKSKQLQKGLKELSEEGATQVFMPQISNDLIVGAVGVLQFDVVAYRLKEEYKVDCVYEPVSVNTVRWIHCDDEKILNEFKKKAHDQLSIDGGGHLTYLAPSRVNLQIMQERWPDIEFRSTREH
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..-..--.--..220.-......230.......--240....--------...250.--------......260.......270.......280.----------......290......---.---300.......310.......320.......330.......340.......350.......360.....---.---.370.......380..-...-.--.390.......400.......410...--....420.......-430.......440.......450.......460..------.....470.......480.......490.......500----......----------...510.......520.......530.----------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MYF
M
S
F
K
D
E
L
A
A
Q
V
A
QR
R
T
F
A
I
I
SHPDAGK
T
T
M
T
E
K
L
L
L
W
G
K
A
I
Q
V
A
G
M
V
K
SRKSDRAA
T
S
D
W
M
E
M
E
K
ERGIS
I
T
T
S
V
M
QFPYKG
H
T
I
N
L
LDTPGHEDFS
E
D
T
Y
R
T
L
T
A
VDS
A
L
M
V
IDGAKG
V
E
E
R
T
I
K
L
M
E
V
CRMRD
T
P
I
I
S
F
V
N
K
M
D
R
E
I
R
E
P
L
E
L
L
D
E
I
E
N
VLN
I
R
C
V
P
ITWPLGMG
R
D
F
A
G
V
Y
N
I
L
ED
K
L
Y
V
Y
KAGFG
S
T
I
T
D
I
E
VRDGY-
D
H
--
A
--
D
I
R
E
K
V
-
G
E
L
A
W
A
S
F
E
E
S
L
E
L
V
Q
--
M
ANEPLD--------R
G
L
F
LQG--------KQT
P
V
L
F
G
T
A
L
GNF
G
V
D
H
V
L
D
A
F
M
HWAPEP----------KAH
P
T
Q
E
R
V
V
E
A
K
EE---G---FS
G
F
V
F
K
I
QANMD
P
K
H
R
D
R
I
A
F
M
R
ICSG
K
Y
EKGLKMN
H
V
R
I
S
K
E
V
R
I
S
D
A
L
T
F
L
AG
E
R
E
H
L
E
E
AWPG
D
---
I
---
I
G
LHNH
G
T
I
Q
IG
D
T
FT-SGE-
N
--
L
H
FTGIPHF
A
P
E
M
F
R
R
V
RLKDP
L
K
S
K
Q
--
L
Q
K
G
L
K
E
L
S
EEGA
T
-
Q
V
F
MPQISN
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
A
Y
R
L
K
E
E
Y
K
V
D
------
C
V
YEPVSV
N
T
V
R
W
I
HCD
D
E
K
I
L
N
E
F
K
K
KAH
D
Q
L
S
ID------GGG
H
L
T
----------
Y
LAPS
R
V
N
L
Q
I
M
Q
E
RWPDIEFRSTREH----------------------------------------------------------------------------------------------------------------------------
73
HHSearch
94.01
64%
-89
- C2 -
-
3TR5
1
RF3_COXBU
B:
[6-527]
---------
V
E
K
Q
T
A
M
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
L
A
G
T
I
K
S
R
----
H
A
T
S
D
W
M
E
L
E
K
Q
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
K
D
Y
L
I
N
L
L
D
T
P
G
H
A
D
F
T
E
D
T
Y
R
T
L
T
A
V
D
S
A
L
M
V
I
D
A
A
K
G
V
E
P
R
T
I
K
L
M
E
V
C
R
L
R
H
T
P
I
M
T
F
I
N
K
M
D
R
D
T
R
P
S
I
E
L
L
D
E
I
E
S
I
L
R
I
H
C
A
P
V
T
W
P
I
G
M
G
K
Y
F
K
G
I
Y
H
L
I
E
D
A
I
Y
L
Y
Q
P
--------
S
E
R
I
E
G
I
-
N
N
--
P
--
E
L
D
K
K
L
-
G
D
-
L
A
S
E
L
R
N
E
I
E
L
V
K
--
G
A
S
H
P
F
E
--------
R
E
G
Y
L
K
G
--------
E
L
T
P
I
F
F
G
S
A
I
N
N
F
G
V
G
E
L
L
D
A
F
V
K
E
A
P
P
P
----------
Q
G
R
E
T
N
S
R
L
V
K
P
E
E
E
---
K
---
F
S
G
F
V
F
K
I
Q
A
N
M
---
H
R
D
R
I
A
F
L
R
I
A
S
G
Q
Y
Q
K
G
M
K
A
Y
H
V
R
L
K
K
E
I
Q
I
N
N
A
L
T
F
M
A
G
K
R
E
N
A
E
E
A
W
P
G
D
---
I
---
I
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
R
--
F
K
F
T
G
I
P
N
F
A
S
E
L
F
R
L
V
R
L
K
D
P
L
K
Q
K
A
--
L
L
K
G
L
T
Q
L
S
E
E
G
A
T
-
Q
L
F
R
P
L
D
S
N
E
L
I
L
G
A
V
G
L
L
Q
F
D
V
V
A
Y
R
L
E
N
E
Y
N
V
K
------
C
V
Y
E
S
V
N
V
V
T
A
R
W
V
I
C
D
D
K
A
V
L
E
R
F
N
Q
E
Q
S
R
N
L
A
Y
D
------
G
G
G
H
L
T
----------
Y
L
A
P
S
R
V
N
L
E
I
T
M
E
K
W
P
E
I
Q
F
S
E
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.23
63%
-85
- C2 -
-
3TR5
1
RF3_COXBU
A:
[9-528]
------------
Q
T
A
M
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
L
A
G
T
I
K
S
R
----
H
A
T
S
D
W
M
E
L
E
K
Q
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
K
D
Y
L
I
N
L
L
D
T
P
G
H
A
D
F
T
E
D
T
Y
R
T
L
T
A
V
D
S
A
L
M
V
I
D
A
A
K
G
V
E
P
R
T
I
K
L
M
E
V
C
R
L
R
H
T
P
I
M
T
F
I
N
K
M
D
R
D
T
R
P
S
I
E
L
L
D
E
I
E
S
I
L
R
I
H
C
A
P
V
T
W
P
I
G
M
G
K
Y
F
K
G
I
Y
H
L
I
E
D
A
I
Y
L
Y
Q
P
G
K
H
E
R
V
G
E
S
E
R
I
E
G
I
-
N
N
--
P
--
E
L
D
K
K
L
-
G
D
L
A
-
S
E
L
R
N
E
I
E
L
V
K
--
G
A
S
H
P
F
E
--------
R
E
G
Y
L
K
G
--------
E
L
T
P
I
F
F
G
S
A
I
N
N
F
G
V
G
E
L
L
D
A
F
V
K
E
A
P
P
P
----------
Q
G
R
E
T
N
S
R
L
V
K
P
E
E
E
---
K
---
F
S
G
F
V
F
K
I
Q
A
N
M
D
-
G
H
R
D
R
I
A
F
L
R
I
A
S
G
Q
Y
Q
K
G
M
K
A
Y
H
V
R
L
K
K
E
I
Q
I
N
N
A
L
T
F
M
A
G
K
R
E
N
A
E
E
A
W
P
G
D
---
I
---
I
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
R
--
F
K
F
T
G
I
P
N
F
A
S
E
L
F
R
L
V
R
L
K
D
P
L
K
Q
K
A
--
L
L
K
G
L
T
Q
L
S
E
E
G
A
T
-
Q
L
F
R
P
L
D
S
N
E
L
I
L
G
A
V
G
L
L
Q
F
D
V
V
A
Y
R
L
E
N
E
Y
N
V
K
------
C
V
Y
E
S
V
N
V
V
T
A
R
W
V
I
C
D
D
K
A
V
L
E
R
F
N
Q
E
Q
S
R
N
L
A
Y
D
------
G
G
G
H
L
T
----------
Y
L
A
P
S
R
V
N
L
E
I
T
M
E
K
W
P
E
I
Q
F
S
E
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.10
65%
-92
- C2 -
-
2H5E
1
RF3_ECOLI
A:
[9-529]
------------
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
Q
-------------------------------
I
T
T
S
V
M
Q
F
P
Y
H
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
V
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
P
M
E
L
L
D
E
V
E
N
E
L
K
I
G
C
A
P
I
T
W
P
I
G
C
G
K
L
F
K
G
V
Y
H
L
Y
K
D
E
T
Y
L
Y
Q
S
G
K
G
H
T
I
Q
E
V
R
I
V
K
G
L
-
N
N
--
P
--
D
L
D
A
A
V
-
G
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
--
G
A
S
N
E
F
D
--------
K
E
L
F
L
A
G
--------
E
I
T
P
V
F
F
G
T
A
L
G
N
F
G
V
D
H
M
L
D
G
L
V
E
W
A
P
A
P
----------
M
P
R
Q
T
D
T
R
T
V
E
A
S
E
D
---
K
---
F
T
G
F
V
F
K
I
Q
A
N
M
D
P
K
H
R
D
R
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
T
A
K
D
V
V
I
S
D
A
L
T
F
M
A
-----
V
E
E
A
Y
P
G
D
---
I
---
L
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
M
--
M
K
F
T
G
I
P
N
F
A
P
E
L
F
R
R
I
R
L
K
D
P
---
K
Q
--
L
L
K
G
L
V
Q
L
S
E
E
G
A
V
-
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
N
V
E
------
A
V
Y
E
S
V
N
V
A
T
A
R
W
V
E
C
A
D
A
K
K
F
E
E
F
K
R
K
N
E
S
Q
L
A
L
D
------
G
G
D
N
L
A
----------
Y
I
A
T
S
M
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------
63
Fugue
91.02
64%
-91
- C2 -
-
2H5E
1
RF3_ECOLI
A:
[3-529]
------
L
S
P
Y
L
Q
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
-------------------------------
Q
I
T
T
S
V
M
Q
F
P
Y
H
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
V
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
P
M
E
L
L
D
E
V
E
N
E
L
K
I
G
C
A
P
I
T
W
P
I
G
C
G
K
L
F
K
G
V
Y
H
L
Y
K
D
E
T
Y
L
Y
Q
S
G
K
G
H
T
I
Q
E
V
R
I
V
K
G
L
-
N
N
--
P
--
D
L
D
A
A
V
-
G
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
--
G
A
S
N
E
F
D
--------
K
E
L
F
L
A
G
--------
E
I
T
P
V
F
F
G
T
A
L
G
N
F
G
V
D
H
M
L
D
G
L
V
E
W
A
P
A
P
----------
M
P
R
Q
T
D
T
R
T
V
E
A
S
E
D
---
K
---
F
T
G
F
V
F
K
I
Q
A
N
M
D
P
K
H
R
D
R
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
T
A
K
D
V
V
I
S
D
A
L
T
F
M
A
-----
V
E
E
A
Y
P
G
D
---
I
---
L
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
M
--
M
K
F
T
G
I
P
N
F
A
P
E
L
F
R
R
I
R
L
K
D
P
---
K
Q
--
L
L
K
G
L
V
Q
L
S
E
E
G
A
V
-
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
N
V
E
------
A
V
Y
E
S
V
N
V
A
T
A
R
W
V
E
C
A
D
A
K
K
F
E
E
F
K
R
K
N
E
S
Q
L
A
L
D
------
G
G
D
N
L
A
----------
Y
I
A
T
S
M
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.18
65%
-92
- C2 -
-
2H5E
1
RF3_ECOLI
B:
[9-529]
------------
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
Q
--------------------------------
T
T
S
V
M
Q
F
P
Y
H
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
V
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
P
M
E
L
L
D
E
V
E
N
E
L
K
I
G
C
A
P
I
T
W
P
I
G
C
G
K
L
F
K
G
V
Y
H
L
Y
K
D
E
T
Y
L
Y
Q
S
G
K
G
H
T
I
Q
E
V
R
I
V
K
G
L
-
N
N
--
P
--
D
L
D
A
A
V
-
G
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
--
G
A
S
N
E
F
D
--------
K
E
L
F
L
A
G
--------
E
I
T
P
V
F
F
G
T
A
L
G
N
F
G
V
D
H
M
L
D
G
L
V
E
W
A
P
A
P
----------
M
P
R
Q
T
D
T
R
T
V
E
A
S
E
D
---
K
---
F
T
G
F
V
F
K
I
Q
A
--------
R
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
T
A
K
D
V
V
I
S
D
A
L
T
F
M
A
-----
V
E
E
A
Y
P
G
D
---
I
---
L
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
M
--
M
K
F
T
G
I
P
N
F
A
P
E
L
F
R
R
I
R
L
K
D
----
K
Q
--
L
L
K
G
L
V
Q
L
S
E
E
G
A
V
-
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
N
V
E
------
A
V
Y
E
S
V
N
V
A
T
A
R
W
V
E
C
A
D
A
K
K
F
E
E
F
K
R
K
N
E
S
Q
L
A
L
D
------
G
G
D
N
L
A
----------
Y
I
A
T
S
M
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.09
58%
-73
- C2 -
-
3VR1
1
RF3_DESVM
A:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
K
A
A
R
H
A
T
S
D
W
M
A
M
E
R
E
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
A
-----
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
75
HHSearch
86.93
57%
-73
- C2 -
-
3VQT
1
RF3_DESVM
A:
[23-546]
--------
R
L
E
R
E
A
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
--------------------
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
-------
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
-
Q
A
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
N
-------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
-
E
S
K
E
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
74
HHSearch
86.61
57%
-68
- C2 -
-
3VR1
1
RF3_DESVM
C:
[23-546]
--------
R
L
E
R
E
A
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
K
A
A
R
H
A
T
S
D
W
M
A
M
E
R
E
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
A
-----
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
-
Q
A
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
-
E
S
K
E
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.93
58%
-72
- C2 -
-
3VR1
1
RF3_DESVM
C:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
K
A
A
R
H
A
T
S
D
W
M
A
M
E
R
E
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
A
-----
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.83
58%
-71
- C2 -
-
3VR1
1
RF3_DESVM
D:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
K
A
A
R
H
A
T
S
D
W
M
A
M
E
R
E
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
A
-----
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.60
58%
-78
- C2 -
-
3VQT
1
RF3_DESVM
A:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
--------------------
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
-------
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
N
-------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.48
58%
-73
- C2 -
-
3VR1
1
RF3_DESVM
B:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
R
K
A
A
R
H
A
T
S
D
W
M
A
M
E
R
E
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
A
-----
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.97
58%
-76
- C2 -
-
3VQT
1
RF3_DESVM
D:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
------------------------
S
V
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
S
-----
R
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
N
----
H
R
D
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
83.72
58%
-73
- C2 -
-
3VQT
1
RF3_DESVM
B:
[33-546]
------------------
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
S
V
K
A
----------------------
T
T
S
V
M
Q
F
P
Y
R
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
P
L
D
V
M
A
D
I
E
Q
H
L
Q
I
E
C
A
P
M
T
W
P
I
G
M
G
S
S
F
K
G
T
Y
D
L
L
H
K
Q
L
H
L
F
-------
I
Q
S
G
I
V
I
H
G
A
-
D
D
--
P
--
Q
L
D
E
Y
L
-
G
D
Q
A
-
E
Q
L
R
M
D
L
A
L
L
E
--
E
A
G
T
P
F
D
--------
E
E
R
Y
L
K
G
--------
E
L
T
P
V
F
F
G
S
A
I
N
N
F
G
V
R
E
M
L
D
M
F
V
E
F
A
P
G
P
----------
Q
P
R
P
A
A
T
R
V
V
E
P
G
E
E
---
A
---
F
T
G
V
V
F
K
I
Q
A
--------
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
K
D
V
T
V
A
N
A
T
I
F
M
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
---
I
---
I
G
I
P
N
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
N
F
A
P
E
H
F
R
R
V
R
L
K
N
P
L
K
A
K
Q
--
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
-
Q
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
G
V
D
------
A
V
Y
E
G
V
S
T
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
A
D
F
Q
D
Y
H
R
G
E
L
A
V
D
------
A
E
G
A
L
A
----------
Y
L
A
P
N
P
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.50
65%
-
- C3 -
-
2O0F
-
RF3_ECOLI
A:
[9-528]
------------
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
Q
-------------------------------
I
T
T
S
V
M
Q
F
P
Y
H
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
V
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
P
M
E
L
L
D
E
V
E
N
E
L
K
I
G
C
A
P
I
T
W
P
I
G
C
G
K
L
F
K
G
V
Y
H
L
Y
K
D
E
T
Y
L
Y
Q
S
G
K
G
H
T
I
Q
E
V
R
I
V
K
G
L
-
N
N
--
P
--
D
L
D
A
A
V
-
G
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
--
G
A
S
N
E
F
D
--------
K
E
L
F
L
A
G
--------
E
I
T
P
V
F
F
G
T
A
L
G
N
F
G
V
D
H
M
L
D
G
L
V
E
W
A
P
A
P
----------
M
P
R
Q
T
D
T
R
T
V
E
A
S
E
D
---
K
---
F
T
G
F
V
F
K
I
Q
A
N
M
D
P
K
H
R
D
R
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
T
A
K
D
V
V
I
S
D
A
L
T
F
M
A
-----
V
E
E
A
Y
P
G
D
---
I
---
L
G
L
H
N
H
G
T
I
Q
I
G
D
T
F
T
-
Q
G
E
-
M
--
M
K
F
T
G
I
P
N
F
A
P
E
L
F
R
R
I
R
L
K
D
P
---
K
Q
--
L
L
K
G
L
V
Q
L
S
E
E
G
A
V
-
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
N
V
E
------
A
V
Y
E
S
V
N
V
A
T
A
R
W
V
E
C
A
D
A
K
K
F
E
E
F
K
R
K
N
E
S
Q
L
A
L
D
------
G
G
D
N
L
A
----------
Y
I
A
T
S
M
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
-----------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.25
29%
-19
- C2 -
-
2XEX
-
EFG_STAAU
A:
[9-473]
---------------
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-----------------------------
T
S
A
A
T
T
A
A
W
E
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
D
L
G
T
E
I
E
E
I
E
I
P
--
E
-
D
H
--
L
--
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
--------
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
LD
V
K
P
I
I
G
H
R
A
S
N
P
E
E
E
V
I
A
K
A
D
D
S
---
A
E
--
F
A
A
L
A
F
K
V
M
T
--
D
P
-
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
---
I
A
A
A
V
G
L
K
D
T
G
T
---
G
D
T
L
C
-
G
E
K
-
N
D
-
I
I
L
E
S
M
E
F
P
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
--
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
------
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.15
31%
-23
- C2 -
-
4M1K
1
?
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-------------------------------
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PNG
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
EK
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.98
31%
-22
- C2 -
-
2J7K
1
EFG_THETH
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
----------------------------
I
T
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LDIP
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PN
G
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.83
31%
-24
- C2 -
-
4MYT
1
EFG_THETH
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-------------------------------
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PN
G
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
EK
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
56.66
28%
-9
- C2 -
-
4M1K
1
?
A:
[6-688]
E
Y
----------
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
-------------------------------
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
-
L
D
--
Q
A
R
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
--------
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
---
P
NG
P
L
A
A
L
A
F
K
I
M
A
D
---
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
PR
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
--
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
ANVGKP
Q
V
A
Y
R
E
T
I
T
K
P
V
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
RGS
G
F
E
F
V
N
AIVGGVIPKE
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
LY
D
G
S
Y
HEVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
GD
P
V
I
L
E
P
I
M
R
V
E
V
T
T
PEEY
M
G
D
V
I
G
D
L
N
A
R
RGQIL
G
M
E
P
R
GN
A
Q
V
I
R
A
F
V
P
LAEMFG
Y
A
T
D
L
R
S
K
T
Q
GR
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
LI
13
PsiBlast_PDB
56.55
31%
-16
- C2 -
-
1FNM
1
EFG_THETH
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
--------------------------------
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LDIP
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PNG
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.51
31%
-23
- C2 -
-
2BM1
1
EFG_THETH
A:
[13-474]
-----------------
R
N
I
V
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-----------------------------
I
T
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LDIP
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PNG
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.31
31%
-18
- C2 -
-
2BM0
1
?
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
------------------------
T
I
T
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LDIP
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PNG
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.59
31%
-20
- C2 -
-
4MYU
1
EFG_THETH
A:
[13-474]
-----------------
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
--------------------------------
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
--
A
R
-
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
--------
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
LDI
P
P
I
----
K
G
T
T
P
E
G
E
V
V
E
I
H
P
D
PN
G
P
---
L
A
A
L
A
F
K
I
M
A
--
D
P
-
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
---
V
G
L
K
E
T
I
T
---
G
D
T
L
V
-
G
E
D
-
A
--
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
46.57
31%
-70
- C2 -
-
1DAR
1
?
?:
[1-328]
-----
M
A
V
K
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
--------------------------------
R
A
A
V
T
T
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
-
L
D
Q
A
R
--
E
Y
H
E
K
L
-
V
E
V
A
-
A
D
F
D
E
N
I
M
L
K
Y
--
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
--------
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------