@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKS8: (2017-10-29 )
MIGALMLDIAGTELTQEDIELLQAPQVGGMILFARNIESPQQVRALTDHMRQVRPDILIAVDQEGGRVQRLKSGFTLLPAMGRFGELYITQPQKALELAEQCGWLMATEVLAVGIDFSFAPVLDLNAISDVIGDRGFSKNIEDIAPLAGAFMRGMKKAGMANTGKHFPGHGSVKADSHVAAAIDSRSYDEIYNHDMQSFIKLMPELDALMPAHVIYDQVDLNPAGFSPFWIQEVLRNRLKFNGVLFSDDLSMQAACVAGGADARIQAALAAGCDMGLVCNDRSAACTALDGITNLELPNQERLERMRGRIPQIQVGETLSLGNDWQAVKTAIEEFKNSF
Atome Classification :
(36 SA)
.........10...-----------.....20........30........40........50..--.-.....60........70..-.-.....80........90........100.......110.......120....-..--.130.......140.......150.......160.......170.......180.......190.......200...--.-...210.......220........230.......240.......250.......260.......270.......280-.------------......290--....-.-------..-----300.......310.......---320........330.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
G
A
L
M
L
DIAGTEL-----------
T
Q
E
D
I
E
L
LQAPQVG
G
M
I
L
F
ARNIE
S
P
Q
Q
V
R
A
L
T
D
H
M
R
Q
V--R-P
D
I
L
I
A
VDQEG
G
R
V
Q
R
L
KS-G-
F
T
LLPAMGRF
G
E
L
Y
ITQ
P
Q
K
A
L
E
L
A
E
QC
G
W
L
M
A
T
E
V
L
A
VGIDFSFA
P
V
L
D
L
N
-
A
I
--
S
D
V
I
GDRGFSK
N
I
E
D
I
A
P
L
A
G
A
F
M
R
G
M
K
KAGMANTGKHFPGHGSVKADS
H
V
A
A
A
IDSR
S
Y
D
E
I
Y
N
H
D
M
Q
S
F
I
K
L
M
P
E
--
L
-
D
A
LM
P
A
H
V
I
Y
D
QVDL-NPAGF
S
P
F
W
I
Q
E
V
L
R
N
R
LKFN
G
V
L
FSDDLS
M
Q
A
A
C
VAGGA
D
A
R
I
Q
A
A
L
AAGCD
M
G
L
V
CNDR-S------------
A
A
C
T
A
LDGI--TNLE-L-------P
N
-----
Q
E
R
L
E
R
M
RGRIP
Q
I
QVG
E
T
L---SL-GN
D
W
Q
A
V
K
T
A
I
E
E
F
KNSF
22
PsiBlast_CBE
88.41
61%
-51
- C4 -
-
5G3R
4
NAGZ_PSEAE
B:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
4
PsiBlast_PDB
87.51
61%
-57
- C4 -
-
5G5K
1
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
3
PsiBlast_PDB
87.31
61%
-50
- C4 -
-
5G3R
3
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
25
PsiBlast_CBE
87.18
60%
-50
- C4 -
-
5LY7
2
NAGZ_PSEAE
B:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
A
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
7
PsiBlast_PDB
86.75
60%
-50
- C4 -
-
5LY7
3
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
A
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
24
PsiBlast_CBE
86.69
61%
-53
- C4 -
-
5G1M
1
NAGZ_PSEAE
B:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
21
PsiBlast_CBE
86.69
61%
-53
- C4 -
-
5G5K
1
NAGZ_PSEAE
B:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
57
HHSearch
86.33
60%
-54
* C4 *
-
5G3R
3
NAGZ_PSEAE
A:
[23-332]
-
G
S
-
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
R
A
I
A
D
N
P
N
-----
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
-
H
Q
R-
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
Q
R
L
K
V
T
P
P
-------
S
R
LQRM-
R
G
K
G
Y
A
N
T
D
Y
----------------------------------
23
PsiBlast_CBE
85.75
61%
-58
- C4 -
-
5G2M
1
NAGZ_PSEAE
B:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
----
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
1
PsiBlast_PDB
85.46
61%
-49
- C4 -
-
5G1M
1
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
2
PsiBlast_PDB
84.38
61%
-52
- C4 -
-
5G2M
1
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
---
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
5
PsiBlast_PDB
84.27
60%
-50
- C4 -
-
5G5U
-
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
R
--
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
A
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
58
HHSearch
84.09
60%
-60
- C4 -
-
5G1M
1
NAGZ_PSEAE
B:
[23-332]
-
G
S
-
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
R
A
I
A
D
N
P
N
-----
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
-
H
Q
R-
S
A
V
V
G
S
R
A
F
E
G
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
A
D
S
H
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
QR
L
K
V
T
P
P
-------
S
R
LQRM-
R
G
K
G
Y
A
N
T
D
Y
----------------------------------
6
PsiBlast_PDB
81.55
60%
-55
- C4 -
-
5G6T
1
NAGZ_PSEAE
A:
[21-325]
M
Q
G
S
L
M
L
D
I
G
G
T
W
L
-----------
T
A
E
D
R
Q
I
L
R
H
P
E
V
G
G
L
I
I
F
A
R
N
I
E
H
P
A
Q
V
R
E
L
C
A
A
I
R
A
I
--
R
-
P
D
L
L
L
A
V
D
Q
E
G
G
R
V
Q
R
L
R
Q
-
G
-
F
V
R
L
P
A
M
-----
R
A
I
A
D
N
P
N
A
E
E
L
A
E
H
C
G
W
L
M
A
T
E
V
Q
A
V
G
L
D
L
S
F
A
P
V
L
D
L
D
H
Q
--------------
D
P
E
R
A
A
L
L
A
G
A
F
I
R
G
M
H
A
A
G
M
A
A
T
G
K
H
F
P
G
H
G
W
A
E
----
V
A
I
P
E
D
A
R
S
L
E
E
I
R
R
S
D
L
V
P
F
A
R
L
A
G
Q
--
L
-
D
A
L
M
P
A
H
V
I
Y
P
Q
V
D
P
-
Q
P
A
G
F
S
R
R
W
L
Q
E
I
L
R
G
E
L
K
F
D
G
V
I
F
S
D
D
L
S
M
A
G
A
H
V
V
G
D
A
A
S
R
I
E
A
A
L
A
A
G
C
D
M
G
L
V
C
N
D
R
-
A
------------
S
A
E
L
A
L
A
A
L
--
Q
R
L
K
-
V
-------
T
P
-----
P
S
R
L
Q
R
M
R
G
K
----------------------------------
52
HHSearch
79.14
47%
-27
- C4 -
-
4GNV
1
?
B:
[14-348]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
-
Y
G
H-
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
E
--
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
G
K
A
L
K
W
D
--
K
---
L
I
A
Q
P
E
Y
L
Q
A
Q
A
L
L
S
S
A
----
8
PsiBlast_PDB
78.59
49%
-31
- C4 -
-
1Y65
1
NAGZ_VIBCH
A:
[3-299]
-
L
G
P
L
W
L
D
V
A
G
Y
E
L
-----------
S
A
E
D
R
E
I
L
Q
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
D
N
Q
Q
L
L
A
L
N
K
A
I
R
Q
A
A
K
R
-
P
-
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
S
R
I
P
P
A
Q
-----
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
-
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
V
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
Y
D
E
R
---
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
GV
L
-
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
-
E
------------
A
A
V
E
V
L
D
N
L
--
P
I
M
E
-
V
-------
P
Q
-----
A
E
A
L
----------------------------------------
31
PsiBlast_CBE
77.85
50%
-24
- C4 -
-
5UTR
1
?
B:
[14-323]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
H
--
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
E
G
G
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
----------------------------------
34
PsiBlast_CBE
77.62
50%
-25
- C4 -
-
4MSS
3
?
B:
[14-323]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
H
--
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
E
G
G
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
----------------------------------
35
PsiBlast_CBE
77.34
50%
-26
- C4 -
-
4GNV
1
?
B:
[14-323]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
H
--
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
E
--
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
----------------------------------
16
PsiBlast_PDB
76.97
50%
-23
- C4 -
-
4MSS
2
?
A:
[14-323]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
H
--
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
E
G
G
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
----------------------------------
15
PsiBlast_PDB
76.61
50%
-27
- C4 -
-
4GNV
1
?
A:
[14-323]
--
G
P
V
M
L
D
V
V
G
T
T
L
-----------
S
R
D
D
A
R
R
L
A
H
P
N
T
G
G
V
I
L
F
A
R
H
F
Q
N
R
A
Q
L
T
A
L
T
D
S
I
R
A
V
--
R
-
E
D
I
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
D
G
-
F
T
V
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
L
L
A
T
K
V
A
T
A
V
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
H
--
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
A
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
L
G
L
S
--
L
-
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
-
R
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
---
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
C
N
Q
P
-
D
------------
A
A
E
V
V
L
N
G
L
K
-
A
R
A
S
-
A
-------
E
S
-----
V
R
R
I
K
R
M
R
A
R
----------------------------------
9
PsiBlast_PDB
76.40
49%
-31
- C4 -
-
2OXN
1
NAGZ_VIBCH
A:
[1-297]
-
M
G
P
L
W
L
D
V
A
G
Y
E
L
-----------
S
A
E
D
R
E
I
L
Q
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
D
N
Q
Q
L
L
A
L
N
K
A
I
R
Q
A
A
K
R
-
P
-
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
S
R
I
P
P
A
Q
-----
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
-
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
V
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
Y
D
E
R
---
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
GV
L
-
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
-
E
------------
A
A
V
E
V
L
D
N
L
--
P
I
M
E
-
V
-------
P
Q
-----
A
E
A
L
----------------------------------------
28
PsiBlast_CBE
75.95
48%
-27
- C4 -
-
4GVH
1
NAGZ_SALTY
B:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
-----
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
--------
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
11
PsiBlast_PDB
75.61
48%
-25
- C4 -
-
4GVG
1
NAGZ_SALTY
A:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
---
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
------
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
27
PsiBlast_CBE
75.48
48%
-25
- C4 -
-
4HZM
2
NAGZ_SALTY
B:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
-----
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
------
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
12
PsiBlast_PDB
75.34
48%
-24
- C4 -
-
4GVH
1
NAGZ_SALTY
A:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
A
D
S
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
M
E
G
A
A
I
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
30
PsiBlast_CBE
75.11
48%
-27
- C4 -
-
4GVF
1
NAGZ_SALTY
B:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
-----
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
--------
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
37
PsiBlast_CBE
75.06
48%
-25
- C4 -
-
4GVI
2
NAGZ_SALTY
B:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
---
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
N
D
L
S
------
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
10
PsiBlast_PDB
75.06
48%
-26
- C4 -
-
4GVF
1
NAGZ_SALTY
A:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
A
D
S
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
M
E
G
A
A
I
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
13
PsiBlast_PDB
75.04
48%
-26
- C4 -
-
4HZM
1
NAGZ_SALTY
A:
[1-303]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
S-
R
-
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
E
--
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
---
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
------
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
------------
G
A
V
S
V
L
D
-----
N
L
S
-
P
-------
I
K
-----
A
E
R
V
T
R
L
-------------------------------------
50
HHSearch
73.99
45%
-20
- C4 -
-
4GVF
1
NAGZ_SALTY
A:
[1-337]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
--
S
R
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
--
E
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
A
D
S
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
M
E
G
A
A
I
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
G
A
V
S
V
L
D
N
LSPI
K
A
E
R
V
T
R
L
Y
H
K
G
S
F
S
-
R
-------
R
E
L
M
D
S-
A
R
W
K
T
A
S
A
Q
L
N
Q
L
H
E
R
W
Q
E
E
------------------------
51
HHSearch
73.84
45%
-18
- C4 -
-
4GVH
2
NAGZ_SALTY
A:
[1-337]
-
M
G
P
V
M
L
N
V
E
G
C
E
L
-----------
D
A
E
E
R
E
I
L
A
H
P
L
V
G
G
L
I
L
F
T
R
N
Y
H
D
P
E
Q
L
R
E
L
V
R
Q
I
R
A
A
--
S
R
N
H
L
V
V
A
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
T
R
L
P
A
A
Q
S
F
F
A
L
H
G
L
--
E
E
G
G
R
L
A
Q
E
A
G
W
L
M
A
S
E
M
I
A
M
D
I
D
I
S
F
A
P
V
L
D
V
G
-
H
I
--
S
A
A
I
G
E
R
S
Y
H
A
D
P
A
K
A
L
A
M
A
T
R
F
I
D
G
M
H
D
A
G
M
K
T
T
G
K
H
F
P
G
H
G
A
V
T
A
D
S
H
K
E
T
P
C
D
P
R
P
E
T
D
I
R
G
K
D
M
S
V
F
R
T
L
I
S
E
NK
L
-
D
A
I
M
P
A
H
V
I
Y
R
A
I
D
P
-
R
P
A
S
G
S
P
Y
W
L
K
T
V
L
R
Q
E
L
G
F
D
G
V
I
F
S
D
D
L
S
M
E
G
A
A
I
M
G
S
Y
A
E
R
A
Q
A
S
L
D
A
G
C
D
M
I
L
V
C
N
N
R
-
K
G
A
V
S
V
L
D
N
LSPI
K
A
E
R
V
T
R
L
Y
H
K
G
S
F
S
-
R
-------
R
E
L
M
D
S-
A
R
W
K
T
A
S
A
Q
L
N
Q
L
H
E
R
W
Q
E
E
------------------------
20
PsiBlast_PDB
73.71
48%
-33
- C4 -
-
3GS6
3
NAGZ_VIBCH
A:
[1-297]
-
M
G
P
L
W
L
D
V
A
G
Y
E
L
-----------
S
A
E
D
R
A
I
L
A
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
D
N
Q
Q
L
L
A
L
N
K
A
I
R
Q
A
A
A
R
-
P
-
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
S
R
I
P
P
A
Q
-----
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
-
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
V
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
---
H
L
E
T
P
Y
D
E
R
---
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
GV
L
-
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
F
K
G
I
V
F
S
D
D
L
S
M
----
V
M
G
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
-
E
------------
A
A
V
E
V
L
D
N
L
--
P
I
M
E
-
V
-------
P
Q
-----
A
E
A
L
----------------------------------------
36
PsiBlast_CBE
73.58
48%
-31
- C4 -
-
3GSM
3
NAGZ_VIBCH
A:
[1-297]
-
M
G
P
L
W
L
D
V
A
G
Y
E
L
-----------
S
A
E
D
R
A
I
L
A
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
D
N
Q
Q
L
L
A
L
N
K
A
I
R
Q
A
A
A
R
-
P
-
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
-
F
S
R
I
P
P
A
Q
-----
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
-
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
V
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
-
H
L
E
T
P
Y
D
E
R
---
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
GV
L
-
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
F
K
G
I
V
F
S
D
D
L
S
M
----
V
M
G
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
-
E
------------
A
A
V
E
V
L
D
N
L
--
P
I
M
E
-
V
-------
P
Q
-----
A
E
A
L
----------------------------------------
56
HHSearch
72.82
48%
-27
- C4 -
-
2OXN
1
NAGZ_VIBCH
A:
[4-327]
----
L
W
L
D
V
A
G
Y
E
L
-----------
S
A
E
D
R
E
I
L
Q
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
D
N
Q
Q
L
L
A
L
N
K
A
I
R
Q
A
--
A
K
R
P
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
R
E
-
G
F
S
R
I
P
P
A
Q
Y
Y
A
R
A
E
N
G
------
V
E
L
A
E
Q
G
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
-
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
V
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
Y
D
---
E
R
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
G-
V
L
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
-
E
------------
A
A
V
E
V
L
D
N
L
PI
M
E
V
P
-
Q
AEALLKK
Q
Q
F
S
Y
S
E
L
K
R
L
E
R
W
Q
Q
A
S
A
N
M
Q
R
L
I
E
Q
------------------------
59
HHSearch
62.07
30%
-15
- C4 -
-
3SQL
5
?
A:
[21-380]
I
A
Q
M
I
V
V
R
G
A
G
Y
L
F
DYERPYPQWEA
D
Q
T
T
L
Q
R
W
I
E
A
G
I
G
G
V
I
L
L
G
G
S
---
A
A
E
V
A
Q
K
T
K
Q
L
Q
S
W
--
A
E
I
P
L
L
I
A
A
D
I
E
E
G
V
G
Q
R
F
R
--
G
-
A
T
E
F
P
P
P
M
A
F
G
E
I
W
R
T
D
P
H
Q
A
I
A
L
A
E
T
M
G
A
T
T
A
Q
E
A
L
S
L
G
I
N
W
V
L
A
P
V
L
D
V
N
-
N
N
PH
N
P
V
I
N
I
R
A
F
G
E
T
P
D
Q
V
S
A
L
G
T
A
F
I
R
G
A
Q
Q
Y
A
V
L
T
T
A
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
A
L
P
T
I
S
H
D
D
T
R
L
N
T
V
E
L
P
P
F
K
A
A
I
Q
G
G-
V
-
D
A
V
M
N
A
H
L
M
I
P
A
W
D
Q
Q
Y
P
A
T
L
S
P
A
I
L
T
G
Q
L
R
H
K
L
G
F
K
G
L
I
V
T
D
A
L
V
M
G
G
I
T
Q
F
A
A
P
D
T
V
V
V
Q
A
I
A
A
G
A
D
I
L
L
M
P
P
D
V
D
G
------------
A
I
I
A
I
E
T
A
I
K
T
G
Q
L
S
-
E
-------
S
R
I
Y
E
S
-
V
E
R
I
W
Q
A
K
Q
K
I
L
T
A
T
P
S
T
F
P
QGI
S
G
D
R
P
E
T
R
K
T
V
A
M
V
L
E
-----