@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ34: (2017-11-24 )
MQTLHVELGERRYPIFIGSQLDPKQLLEPYIHGQQVMIVSNVTVAPLYLSHYQEALESLGKTVATCILPDGEKYKDIQHLNLIFDALLEAGFNRDCTVLALGGGVIGDMAGFASACFQRGVYFVQVPTTLLSQVDSSVGGKTGINHPLGKNMLGAFQQPQVVLADMAQLNTLPERELSAGLAEVIKYALLGDEDFLVWLEENMDGLVARDADLLAEAVYRSCAHKARIVANDEKEQGERALLNLGHTFGHAIESYLGYGTWLHGEAVATGMVMAADLSQRLGWISNEDVARTKKIIQRANLPISCPQIPLDDFLGHMAHDKKVLNGQLRLVLLKQLGQAVITKDFDVELMKQAILANQHG
Atome Classification :
(45 SA)
.........10........20--.-.---..-....30........40........50.....--...60------.......------.70........80........90--...-.....-100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.-...---..-.--------------210-----.-----------........220.......230.......240.......250.......260.......270.......280.......290.......300..-.-----------.-----------.-.-----------.310.......320.......330--..-.-....340.--....--..350.......360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
T
L
H
V
ELG
E
R
R
Y
P
I
F
IGSQL--
D
-
P
---
K
Q
-
L
L
E
P
YIHG
Q
Q
V
M
I
V
SN
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
--
E
S
L
G
K
------
T
V
A
T
CIL------PDG
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
AG--FNR-D
C
T
V
L
-
A
LGG
G
V
I
G
D
M
A
G
F
A
S
A
C
F
QR
G
V
Y
F
V
QV
P
T
T
L
L
S
Q
V
D
S
SVGGKTGINHPL
G
K
N
M
L
G
AFQQ
P
Q
V
V
L
A
D
M
A
Q
LNTL
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
LLGDE
D
F
L
V
W
L
E
ENM-
D
G
L
---VA-R--------------
D
-------
A
-----------
D
L
L
A
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A
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Y
R
S
C
AH
K
A
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E
K
E
Q
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A
L
L
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G
H
T
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A
I
E
S
Y
LGYGTWLH
G
E
A
V
AT
G
M
V
M
A
A
D
L
S
Q
RLGWISN
E
D
V
A
R
T
K
K
I
I
Q
RANLPIS-C-----------P-----------Q-I-----------
P
L
D
D
F
L
G
H
M
AHD
K
K
VLNG
Q
L
R
L
V
L
--
L
K
-
Q
-
L
G
Q
A
V
ITK--DF
D
V
--
E
L
M
K
Q
A
I
LANQHG
21
PsiBlast_CBE
98.89
99%
-139
- C3 -
-
5EKS
1
?
B:
[9-368]
M
Q
T
L
H
V
E
L
--
R
R
Y
P
I
F
I
G
S
Q
L
--
D
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---
K
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Y
I
H
G
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Q
V
M
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T
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A
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Y
L
S
H
Y
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A
L
--
E
S
L
G
K
------
T
V
A
T
C
I
L
------
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
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F
D
A
L
L
E
A
G
--
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N
R
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G
K
T
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L
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M
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M
A
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T
L
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A
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L
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Y
A
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L
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D
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D
F
L
V
W
L
E
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N
M
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D
G
L
---
V
A
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R
--------------
D
-------
A
-----------
D
L
L
A
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A
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Y
R
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C
A
H
K
A
R
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A
N
D
E
----
E
R
A
L
L
N
L
G
H
T
F
G
H
A
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S
Y
L
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Y
G
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W
L
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N
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A
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-----------
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D
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L
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A
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K
K
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--
G
Q
L
R
L
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L
--
L
K
-
Q
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L
G
Q
A
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K
--
D
F
D
V
--
E
L
M
K
Q
A
I
L
A
N
Q
H
G
1
PsiBlast_PDB
98.14
99%
-142
- C3 -
-
5EKS
1
?
A:
[9-368]
M
Q
T
L
H
V
E
L
G
E
R
R
Y
P
I
F
I
G
S
Q
L
--
D
-
P
---
K
Q
-
L
L
E
P
Y
I
H
G
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
--
E
S
L
G
K
------
T
V
A
T
C
I
L
------
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
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F
D
A
L
L
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A
G
--
F
N
R
-
D
C
T
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L
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A
L
G
G
G
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A
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A
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T
L
L
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D
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G
G
K
T
G
I
N
H
P
L
G
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M
L
G
A
F
Q
Q
P
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V
V
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D
M
A
Q
L
N
T
L
P
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R
E
L
S
A
G
L
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V
I
K
Y
A
L
L
G
D
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D
F
L
V
W
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N
M
-
D
G
L
---
V
A
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--------------
D
-------
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L
L
A
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A
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Y
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C
A
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A
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A
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---
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L
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A
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Y
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-----------
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F
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A
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K
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---
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L
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L
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Q
A
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--
D
F
D
V
--
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L
M
K
Q
A
I
L
A
N
Q
H
G
40
HHSearch
86.66
99%
-46
- C3 -
-
5EKS
1
?
B:
[9-368]
M
Q
T
L
H
V
E
L
--
R
R
Y
P
I
F
I
G
S
Q
L
D-
P
-
K
----
Q
-
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L
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Q
Q
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M
I
V
S
N
V
T
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A
P
L
Y
L
S
H
Y
Q
E
A
L
--
E
S
L
G
K
------
T
V
A
T
C
I
L
------
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
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A
G
--
F
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R
-
D
C
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A
L
G
G
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A
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F
A
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A
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P
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L
S
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G
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L
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A
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Q
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L
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D
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W
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A
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A
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A
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H
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A
I
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Y
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N
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A
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K
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I
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P
I
S
-
C
-----------
P
-----------
Q
-
I
-----------
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L
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D
F
L
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Y
M
A
H
D
K
K
V
--
G
Q
L
R
L
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L
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L
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Q
A
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I
T
K
--
D
F
D
V
--
E
L
M
K
Q
A
I
L
A
N
Q
H
G
41
HHSearch
86.02
99%
-50
- C3 -
-
5EKS
1
?
A:
[9-368]
M
Q
T
L
H
V
E
L
G
E
R
R
Y
P
I
F
I
G
S
Q
L
D-
P
-
K
----
Q
-
L
L
E
P
Y
I
H
G
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
--
E
S
L
G
K
------
T
V
A
T
C
I
L
------
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
-
D
C
T
V
L
-
A
L
G
G
G
V
I
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D
M
A
G
F
A
S
A
C
F
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Y
F
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P
T
T
L
L
S
Q
V
D
S
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G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
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V
I
K
Y
A
L
L
G
D
E
D
F
L
V
W
L
E
E
N
M
-
D
G
L
---
V
A
-
R
--------------
D
-------
A
-----------
D
L
L
A
E
A
V
Y
R
S
C
A
H
K
A
R
I
V
A
N
D
E
K
E
---
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
Y
G
T
W
L
H
G
E
A
V
A
T
G
M
V
M
A
A
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S
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R
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I
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N
E
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A
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T
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K
I
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A
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P
I
S
-
C
-----------
P
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Q
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I
-----------
P
L
D
D
F
L
G
Y
M
A
H
D
K
K
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---
Q
L
R
L
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L
--
L
K
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Q
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L
G
Q
A
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I
T
K
--
D
F
D
V
--
E
L
M
K
Q
A
I
L
A
N
Q
H
G
3
PsiBlast_PDB
81.69
52%
-130
- C3 -
-
3OKF
1
AROB_VIBCH
A:
[30-384]
M
E
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
--
F
-
A
---
N
P
-
A
L
L
S
L
S
A
K
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
--
D
H
I
G
C
------
Q
H
A
L
L
E
L
------
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
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M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
I
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A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
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S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
Q
M
-
E
A
L
---
Y
A
-
L
--------------
D
-------
E
-----------
Q
A
L
T
Y
A
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
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--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
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Q
G
L
I
D
A
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Q
F
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A
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K
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H
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P
V
R
-
T
-----------
P
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E
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-----------
T
F
A
D
F
M
Q
H
M
M
R
D
K
K
V
L
A
G
E
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R
L
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L
--
P
T
-
S
-
I
G
T
S
A
V
V
K
--
G
V
P
E
--
A
V
I
A
Q
A
I
------
25
PsiBlast_CBE
80.70
52%
-138
- C3 -
-
3OKF
1
AROB_VIBCH
B:
[30-384]
M
E
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
--
F
-
A
---
N
P
-
A
L
L
S
L
S
A
K
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
--
D
H
I
G
C
------
Q
H
A
L
L
E
L
------
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
I
-
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
Q
M
-
E
A
L
---
Y
A
-
L
--------------
D
-------
E
-----------
Q
A
L
T
Y
A
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
E
S
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
I
D
A
S
Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
V
R
-
T
-----------
P
-----------
E
N
M
-----------
T
F
A
D
F
M
Q
H
M
M
R
----------
L
V
L
--
P
T
-
S
-
I
G
T
S
A
V
V
K
--
G
V
P
E
--
A
V
I
A
Q
A
I
------
46
HHSearch
73.27
53%
-48
- C3 -
-
3OKF
1
AROB_VIBCH
A:
[30-389]
M
E
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F-
A
-
N
---
P
A
-
L
L
S
L
S
-
A
K
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
--
D
H
I
G
C
------
Q
H
A
L
L
E
L
------
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
I
-
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
Q
M
-
E
A
L
---
Y
A
-
L
--------------
D
-------
E
-----------
Q
A
L
T
Y
A
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
I
D
A
S
Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
V
R
-
T
-----------
P
-----------
E
N
M
-----------
T
F
A
D
F
M
Q
H
M
M
R
D
K
K
V
L
A
G
E
L
R
L
V
L
--
P
T
-
S
-
I
G
T
S
A
V
V
K
--
G
V
P
E
--
A
V
I
A
Q
A
I
E
Y
C
R
T
-
45
HHSearch
71.17
53%
-46
- C3 -
-
3OKF
1
AROB_VIBCH
B:
[30-389]
M
E
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F-
A
-
N
---
P
A
-
L
L
S
L
S
-
A
K
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
--
D
H
I
G
C
------
Q
H
A
L
L
E
L
------
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
I
-
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
Q
M
-
E
A
L
---
Y
A
-
L
--------------
D
-------
E
-----------
Q
A
L
T
Y
A
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
E
S
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
I
D
A
S
Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
V
R
-
T
-----------
P
-----------
E
N
M
-----------
T
F
A
D
F
M
Q
H
M
M
R
----------
L
V
L
--
P
T
-
S
-
I
G
T
S
A
V
V
K
--
G
V
P
E
--
A
V
I
A
Q
A
I
E
Y
C
R
T
-
22
PsiBlast_CBE
69.26
55%
-16
- C3 -
-
3ZOK
2
DHQS_ACTCH
D:
[17-374]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L-
D
-
Q
---
P
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
TN
E
N
P
N
V
------
S
V
E
S
V
I
L
------
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
N
F
F
E
W
Q
E
K
N
M
-
P
A
L
---
M
A
-
R
--------------
D
-------
P
-----------
S
A
L
A
Y
A
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
-
P
-----------
P
-----------
E
T
M
-----------
T
V
E
M
F
K
S
V
M
A
V
D
K
K
V
A
D
G
L
L
R
L
I
L
--
L
K
G
P
-
L
G
N
C
V
F
T
G
--
D
Y
D
R
--
K
A
L
D
E
T
L
H
A
----
24
PsiBlast_CBE
69.19
55%
-16
- C3 -
-
3ZOK
6
DHQS_ACTCH
B:
[17-374]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L-
D
-
Q
---
P
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
TN
E
N
P
N
V
------
S
V
E
S
V
I
L
------
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
N
F
F
E
W
Q
E
K
N
M
-
P
A
L
---
M
A
-
R
--------------
D
-------
P
-----------
S
A
L
A
Y
A
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
-
P
-----------
P
-----------
E
T
M
-----------
T
V
E
M
F
K
S
V
M
A
V
D
K
K
V
A
D
G
L
L
R
L
I
L
--
L
K
G
P
-
L
G
N
C
V
F
T
G
--
D
Y
D
R
--
K
A
L
D
E
T
L
H
A
----
2
PsiBlast_PDB
69.01
55%
-13
- C3 -
-
3ZOK
5
DHQS_ACTCH
A:
[17-374]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L-
D
-
Q
---
P
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
TN
E
N
P
N
V
------
S
V
E
S
V
I
L
------
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
N
F
F
E
W
Q
E
K
N
M
-
P
A
L
---
M
A
-
R
--------------
D
-------
P
-----------
S
A
L
A
Y
A
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
-
P
-----------
P
-----------
E
T
M
-----------
T
V
E
M
F
K
S
V
M
A
V
D
K
K
V
A
D
G
L
L
R
L
I
L
--
L
K
G
P
-
L
G
N
C
V
F
T
G
--
D
Y
D
R
--
K
A
L
D
E
T
L
H
A
----
23
PsiBlast_CBE
68.92
55%
-15
- C3 -
-
3ZOK
3
DHQS_ACTCH
C:
[17-374]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L-
D
-
Q
---
P
D
-
L
L
Q
R
H
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
TN
E
N
P
N
V
------
S
V
E
S
V
I
L
------
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
N
F
F
E
W
Q
E
K
N
M
-
P
A
L
---
M
A
-
R
--------------
D
-------
P
-----------
S
A
L
A
Y
A
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
-
P
-----------
P
-----------
E
T
M
-----------
T
V
E
M
F
K
S
V
M
A
V
D
K
K
V
A
D
G
L
L
R
L
I
L
--
L
K
G
P
-
L
G
N
C
V
F
T
G
--
D
Y
D
R
--
K
A
L
D
E
T
L
H
A
----
43
HHSearch
68.29
56%
-9
* C3 *
-
3ZOK
2
DHQS_ACTCH
D:
[18-377]
----
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L-
D
Q
P
---
D
L
-
L
Q
R
H
-
V
H
G
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
--
T
N
E
N
P
NV----
S
V
E
S
V
I
L
------
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
V
-
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
N
F
F
E
W
Q
E
K
N
M
-
P
A
L
---
M
A
-
R
--------------
D
-------
P
-----------
S
A
L
A
Y
A
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
-
P
-----------
P
-----------
E
T
M
-----------
T
V
E
M
F
K
S
V
M
A
V
D
K
K
V
A
D
G
L
L
R
L
I
L
--
L
K
-
G
P
L
G
N
C
V
F
T
G
--
D
Y
D
R
--
K
A
L
D
E
T
L
H
A
F
C
K
-
51
HHSearch
67.79
48%
-63
- C3 -
-
5HVN
1
AROB_FRATT
A:
[14-361]
--------
F
S
P
S
Y
N
I
I
V
D
S
V
L
--
D
-
F
---
S
H
-
I
L
E
Y
V
-
T
N
K
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
L
A
A
L
--
V
D
-
D
L
------
D
V
R
T
C
I
L
------
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
N
S
T
V
L
V
-
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
-
K
D
F
Y
L
W
L
D
S
N
R
-
D
K
I
---
L
A
-
K
--------------
D
-------
S
-----------
V
T
L
I
E
M
V
K
R
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
R
G
L
K
H
G
E
A
V
G
V
G
M
A
Q
A
I
D
F
S
H
Y
L
G
L
I
S
Q
Q
Q
A
K
D
F
N
D
F
I
V
S
F
G
I
S
I
D
-
F
-----------
P
-----------
N
D
I
-----------
C
Q
K
E
F
L
E
A
M
L
L
D
----
N
K
E
L
K
F
I
L
--
I
E
-
N
-
I
G
S
L
S
L
Q
---
K
Q
S
K
--
N
E
L
E
Q
F
L
D
I
S
---
4
PsiBlast_PDB
66.06
50%
-65
- C3 -
-
5HVN
1
AROB_FRATT
A:
[18-354]
------------
Y
N
I
I
V
D
S
V
L
--
D
-
F
---
S
H
-
I
L
E
-
Y
V
T
N
K
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
L
A
A
L
--
V
D
-
D
L
------
D
V
R
T
C
I
L
------
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
-
N
S
T
V
L
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
-
K
D
F
Y
L
W
L
D
S
N
R
-
D
K
I
---
L
A
-
K
--------------
D
-------
S
-----------
V
T
L
I
E
M
V
K
R
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
R
G
L
K
H
G
E
A
V
G
V
G
M
A
Q
A
I
D
F
S
H
Y
L
G
L
I
S
Q
Q
Q
A
K
D
F
N
D
F
I
V
S
F
G
I
S
I
D
-
F
-----------
P
-----------
N
D
I
-----------
C
Q
K
E
F
L
E
A
M
L
L
D
----
N
K
E
L
K
F
I
L
--
I
E
-
N
-
I
G
S
L
S
L
Q
K
--
Q
S
K
N
--
E
L
-----------
63
Fugue
62.70
32%
-115
- C3 -
-
1UJN
-
?
A:
[1-347]
M
Q
R
L
E
V
R
-
E
P
V
P
Y
P
I
L
V
G
E
G
V
--
L
-
K
---
E
-----
V
P
P
L
A
G
P
A
A
L
L
F
D
R
R
V
E
G
F
A
Q
E
V
A
K
A
L
-------
G
------
V
R
H
L
L
G
L
------
P
G
G
E
A
A
K
S
L
E
V
Y
G
K
V
L
S
W
L
A
E
K
G
--
L
P
R
-
N
A
T
L
L
-
V
V
G
G
G
T
L
T
D
L
G
G
F
V
A
A
T
Y
L
R
G
V
A
Y
L
A
F
P
T
T
T
L
A
I
V
D
A
S
V
G
G
K
T
G
I
N
L
P
E
G
K
N
L
V
G
A
F
H
F
P
Q
G
V
Y
A
E
L
R
A
L
K
T
L
P
L
P
T
F
K
E
G
L
V
E
A
F
K
H
G
L
I
A
G
D
E
A
L
L
K
V
E
D
---------
L
T
-
P
--------------
Q
-------
S
-----------
P
R
L
E
A
F
L
A
R
A
V
A
V
K
V
R
V
T
E
E
D
P
L
E
K
G
K
R
R
L
L
N
L
G
H
T
L
G
H
A
L
E
A
Q
T
R
H
A
-
L
P
H
G
M
A
V
A
Y
G
L
L
Y
A
A
L
L
G
R
A
L
G
--
G
E
D
L
L
P
P
V
R
R
L
L
L
W
L
S
P
P
-
P
-
L
-----------
P
-----------
P
-
L
-----------
A
F
E
D
L
L
P
Y
L
S
L
H
W
V
V
P
L
A
P
G
R
L
V
V
R
P
L
P
-
E
-
G
L
L
R
E
A
F
A
--
A
W
R
E
--
E
L
K
G
L
G
L
L
-----
54
HHSearch
61.34
38%
-19
- C3 -
-
1SG6
1
ARO1_EMENI
B:
[10-391]
---------
L
G
R
E
S
I
I
A
D
F
G
L
WR
N
Y
V
---
A
K
D
L
I
S
D
C
-
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
E
I
TP
S
P
R
L
L
I
Y
N
R
------
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
---
L
K
-
A
V
R
R
E
V
T
PGEHRFEG
T
-------
E
-----------
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
-----------
K
-----------
D
-
A
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
--------
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
A
S
V
V
A
N
--
E
D
I
R
V
V
L
------
6
PsiBlast_PDB
58.59
42%
-119
- C3 -
-
3QBE
-
AROB_MYCTU
A:
[77-346]
----------------------------------------------------------------------------------
I
------
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
V
-
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
V
I
L
D
L
I
E
A
D
P
-
Q
A
A
---
L
D
-
P
--------------
A
-------
G
-----------
D
V
L
P
E
L
I
R
R
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
-
R
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
V
S
-
Y
-----------
D
-----------
P
-
D
-----------
A
L
P
Q
L
L
E
I
M
A
G
D
K
K
T
R
A
G
V
L
R
F
V
V
--
L
D
-
G
-
L
A
K
--------------------------
26
PsiBlast_CBE
58.40
42%
-128
- C3 -
-
3QBD
1
AROB_MYCTU
B:
[77-346]
----------------------------------------------------------------------------------
I
------
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
V
-
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
V
I
L
D
L
I
E
A
D
P
-
Q
A
A
---
L
D
-
P
--------------
A
-------
G
-----------
D
V
L
P
E
L
I
R
R
A
I
T
V
K
A
E
V
V
A
A
-----
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
-
R
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
V
S
-
Y
-----------
D
-----------
P
-
D
-----------
A
L
P
Q
L
L
E
I
M
A
--------
V
L
R
F
V
V
--
L
D
-
G
-
L
A
K
--------------------------
44
HHSearch
58.38
38%
-11
- C3 -
-
3QBE
-
AROB_MYCTU
A:
[19-367]
-------
A
V
D
P
P
Y
P
V
V
I
G
T
G
L
L
D
E
-
L
---
E
D
-
L
L
A
D
---
R
H
K
V
A
V
V
H
Q
P
G
L
A
E
-
T
A
E
E
I
R
K
R
L
--
A
G
K
G
V
------
D
A
H
R
I
E
I
------
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
V
-
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
V
I
L
D
L
I
E
A
D
P
-
Q
A
A
---
L
D
-
P
--------------
A
-------
G
-----------
D
V
L
P
E
L
I
R
R
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
R
-
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
V
S
-
Y
-----------
D
-----------
P
-
D
-----------
A
L
P
Q
L
L
E
I
M
A
G
D
K
K
T
R
A
G
V
L
R
F
V
V
--
L
D
-
G
-
L
A
K
P
G
R
M
V
--
G
P
D
P
--
G
L
L
V
T
A
Y
A
G
V
C
A
-
55
HHSearch
58.32
38%
-16
- C3 -
-
1NVB
1
ARO1_EMENI
B:
[10-391]
---------
L
G
R
E
S
I
I
A
D
F
G
L
WR
N
Y
V
---
A
K
D
L
I
S
D
C
-
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
EITPSP
R
L
L
I
Y
N
R
------
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
---
L
K
-
A
VRREVTPGEHRFEG
T
-------
E
-----------
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
-----------
K
-----------
D
-
A
RIRKLTAGKHC
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
AS
V
V
A
N
--
E
D
I
R
V
V
L
------
62
Fugue
57.76
37%
-9
- C3 -
-
1DQS
3
ARO1_EMENI
A:
[4-391]
P
T
K
I
S
I
L
---
G
R
E
S
I
I
A
D
F
G
L
--
W
-
R
NY
V
A
K
-
D
L
I
S
D
C
S
S
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
EITP
S
P
R
L
L
I
Y
N
R
------
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
---
L
K
-
A
--------------
V
R
RRFEGT
E
-----------
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
-----------
K
D
A
R
I
R
K
L
TAGK
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
--
A
S
V
V
A
N
E
D
I
R
V
V
L
------
5
PsiBlast_PDB
56.89
42%
-127
- C3 -
-
3QBD
1
AROB_MYCTU
A:
[77-346]
----------------------------------------------------------------------------------
I
------
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
V
-
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
V
I
L
D
L
I
E
A
D
P
-
Q
A
A
---
L
D
-
P
--------------
A
-------
G
-----------
D
V
L
P
E
L
I
R
R
A
I
T
V
K
A
E
V
V
A
A
-----
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
-
R
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
V
S
-
Y
-----------
D
-----------
P
-
D
-----------
A
L
P
Q
L
L
E
I
M
A
G
-------
V
L
R
F
V
V
--
L
D
-
G
-
L
A
K
--------------------------
27
PsiBlast_CBE
53.14
37%
-29
- C3 -
-
1SG6
1
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
PGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
--------
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
49
HHSearch
52.97
32%
-17
- C3 -
-
1XAG
2
AROB_STAAR
A:
[3-351]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
IK
Y
-
I
---
G
T
-
Y
L
N
Q
---
F
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
D
I
L
--
S
Y
E
N
--------
V
H
K
V
I
I
------
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
-
K
D
R
---
E
I
L
Q
--------------
S
-------
L
-----------
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
H
---
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
-
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
-
M
-----------
I
T----------
D
-
L
-----------
D
F
E
T
L
Y
Q
Y
M
L
S
D
K
K
N
D
K
Q
G
V
Q
M
V
L
--
M
R
-
Q
-
F
G
D
I
V
V
Q
---
H
V
D
Q
--
L
T
L
Q
H
A
C
E
Q
L
K
T
-
8
PsiBlast_PDB
51.25
37%
-15
- C3 -
-
1NR5
2
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
PGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
16
PsiBlast_PDB
50.95
37%
-29
- C3 -
-
1SG6
1
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
PGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-----
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
-------
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
9
PsiBlast_PDB
50.60
37%
-27
- C3 -
-
1NRX
1
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
TPGHRFEGT
E
-
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
-----
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
36
PsiBlast_CBE
50.51
37%
-11
- C3 -
-
1NRX
1
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
PGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
-----
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
32
PsiBlast_CBE
50.48
37%
-13
- C3 -
-
1NVD
2
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-------------------------RFEGT
E
-----
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
11
PsiBlast_PDB
50.22
37%
-21
- C3 -
-
1NVA
1
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
TPGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
A
G
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
-----
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
34
PsiBlast_CBE
50.19
37%
-9
- C3 -
-
1NVA
1
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
P
GEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
A
G
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
---
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
37
PsiBlast_CBE
50.08
37%
-15
- C3 -
-
1NR5
2
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
T
P
GEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
33
PsiBlast_CBE
50.08
37%
-13
- C3 -
-
1NVB
1
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
LLIYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
LKA
V
R
-
R
--------------
E
-------
V
TPGEHRFEGTE
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KDARIRKLTAG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
48
HHSearch
49.86
32%
-29
- C3 -
-
1XAH
1
AROB_STAAR
B:
[3-351]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
IK
Y
-
I
---
G
T
-
Y
L
N
Q
---
F
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
--------
N
--------
V
H
K
V
I
I
------
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
-
K
D
R
---
E
I
L
Q
--------------
S
-------
L
-----------
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
H
---
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
-
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
------------------------------------------
T
L
Y
Q
Y
M
L
--------
G
V
Q
M
V
L
--
M
R
-
Q
-
F
G
D
I
V
V
Q
---
H
V
D
Q
--
L
T
L
Q
H
A
C
E
Q
L
K
T
-
12
PsiBlast_PDB
49.85
37%
-12
- C3 -
-
1NVB
2
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
TPGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
38
PsiBlast_CBE
49.74
37%
-13
- C3 -
-
1DQS
3
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
-----------------------T
E
---------
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
AG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
13
PsiBlast_PDB
49.57
37%
-14
- C3 -
-
1NVD
2
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
RFEGT
E
-----
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
A
G
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
7
PsiBlast_PDB
49.26
37%
-13
- C3 -
-
1DQS
3
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
-----------------------RFEGT
E
-----
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
TAG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
28
PsiBlast_CBE
49.24
37%
-13
- C3 -
-
1NVF
2
ARO1_EMENI
C:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
LLIYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
LKA
V
R
-
R
--------------
E
-------
V
TPGEHRFEGTE
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KDARIRKLTAG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
39
PsiBlast_CBE
49.09
36%
-62
- C3 -
-
1XAI
2
AROB_STAAR
B:
[57-334]
---------------------------------------------------------------------
E
------
N
V
H
K
V
I
I
------
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
K
D
R
E
---
I
L
-
Q
--------------
S
-------
L
-----------
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
-
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
-----------
T
-----------
D
-
L
-----------
D
F
E
T
L
Y
Q
Y
M
L
S
D
K
K
N
D
K
Q
G
V
Q
M
V
L
--
M
R
-
Q
-
F
G
D
I
V
V
-----------------------
29
PsiBlast_CBE
48.80
37%
-10
- C3 -
-
1NVF
3
ARO1_EMENI
B:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
LLIYNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
LKA
V
R
-
R
--------------
E
-------
V
TPGEHRFEGTE
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KDARIRKLTAG
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------
17
PsiBlast_PDB
48.39
36%
-55
- C3 -
-
1XAG
2
AROB_STAAR
A:
[57-334]
---------------------------------------------------------------------
E
------
N
V
H
K
V
I
I
------
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
K
D
R
E
---
I
L
-
Q
--------------
S
-------
L
-----------
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
-
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
-----------
T
-----------
D
-
L
-----------
D
F
E
T
L
Y
Q
Y
M
L
S
D
K
K
N
D
K
Q
G
V
Q
M
V
L
--
M
R
-
Q
-
F
G
D
I
V
V
-----------------------
18
PsiBlast_PDB
48.14
36%
-63
- C3 -
-
1XAI
2
AROB_STAAR
A:
[57-334]
---------------------------------------------------------------------
E
------
N
V
H
K
V
I
I
------
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
I
-
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
K
D
R
E
---
I
L
-
Q
--------------
S
-------
L
-----------
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
-
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
I
-----------
T
-----------
D
-
L
-----------
D
F
E
T
L
Y
Q
Y
M
L
S
D
K
K
N
D
K
Q
G
V
Q
M
V
L
--
M
R
-
Q
-
F
G
D
I
V
V
-----------------------
15
PsiBlast_PDB
48.04
37%
-8
- C3 -
-
1NVF
3
ARO1_EMENI
A:
[40-378]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
--
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
I
-
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
N
A
-
E
T
I
L
K
A
V
R
-
R
--------------
E
-------
V
TPGEHRFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
S
-
L
KD
A
R
I
R
K
L
T
A
G
K
-----------
H
-
C
-----------
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
D
G
P
K
K
K
I
V
L
--
L
S
-
A
-
I
G
T
P
Y
E
T
R
---------------------