@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRF8: (2017-12-02 )
MSRLATRFEKLQSQQRKALVSYVMAGDPQPQVTVPLLHKMVAAGVDVIELGLPFSDPMADGPVIALAAERALAAGTNTLDALNMVKEFREQDQETPVVLMGYLNPVEVIGYEKFVSYAKQCGVDGLLLVDLPPEESKEFGAILKQHDMDQIFLLAPTSTDQRIQHVANQASGFIYYVSLKGVTGAATLDTSEAAARIEKIKGMTNVPVGVGFGISDAASAKAMGSVADAVIVGSAFVKSFATLAADEAVEQTVNKVKELRAALDELV
Atome Classification :
(53 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......-220..-.....230-.......240....--.--..250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
R
L
A
T
R
F
E
K
L
Q
S
Q
Q
R
K
A
L
V
S
Y
V
MAGDPQPQ
V
T
V
P
L
L
H
K
M
V
A
AG
V
D
V
I
E
LGLPFSDPMADG
P
V
I
A
L
A
A
E
R
A
LAAGTN
T
L
D
A
L
N
M
V
K
E
F
R
E
QDQET
P
V
V
L
M
GYL
N
P
V
E
VI
G
Y
E
K
F
V
S
Y
A
K
QCGVD
G
L
L
L
V
DLP
P
E
E
S
K
E
F
G
A
I
L
K
QHDM
D
Q
I
F
L
LAPTS
T
D
Q
R
I
Q
H
V
A
N
QAS
G
F
I
Y
Y
V
S
LKGVTG
A
A
TLD
T
S
E
A
A
A
R
I
E
K
IKGMTNVPVGVGFGISD
A
A
S
-
A
K
A
M
G
-
S
V
A
D
A
V
I
V
-
G
S
A
F
V
K
S
F
A
T
L
A
A
D
--
E
--
A
V
E
Q
T
V
N
K
V
K
E
L
R
A
A
L
D
ELV
113
HHSearch
87.30
43%
-115
- C1 -
-
5KMY
-
TRPA_LEGPA
A:
[4-271]
M
N
R
I
D
K
T
L
E
K
L
K
A
N
R
K
K
M
L
S
P
Y
I
T
A
G
D
P
Y
P
E
L
T
V
S
L
M
H
Q
L
V
K
S
G
A
D
V
L
E
L
G
I
P
F
S
D
P
M
A
E
G
P
V
I
Q
R
A
M
E
R
A
L
A
H
S
I
H
C
D
D
V
L
N
M
V
R
Q
F
R
K
T
D
T
E
T
P
V
I
L
M
G
Y
L
N
P
I
E
Q
Y
G
Y
D
L
F
A
Q
Q
A
V
E
A
G
A
D
G
T
I
L
V
D
L
P
P
E
E
A
D
G
V
S
R
V
W
Q
K
H
G
L
Y
S
I
Y
L
C
S
P
T
T
S
A
E
R
M
N
F
I
N
Q
H
A
N
G
Y
L
Y
Y
V
S
L
-------
A
L
K
L
P
E
L
K
A
Q
Y
L
Q
R
K
A
Q
S
K
L
P
L
M
V
G
F
G
I
K
T
P
E
M
-
A
A
Q
V
A
-
E
F
A
D
G
V
I
V
-
G
A
A
L
I
N
E
I
I
E
A
Y
E
A
--
K
KD
P
L
Q
A
S
G
A
L
L
S
S
M
R
Q
A
I
D
N
I
-
1
PsiBlast_PDB
85.41
45%
-145
- C1 -
-
5K9X
-
TRPA_LEGPH
A:
[5-241]
-
N
R
I
D
K
T
L
E
K
L
K
A
N
R
K
K
M
L
S
P
Y
I
T
A
G
D
P
Y
P
E
L
T
V
S
L
M
H
Q
L
V
K
S
G
A
D
V
L
E
L
G
I
P
F
S
D
---
E
G
P
V
I
Q
R
A
M
E
R
A
L
A
H
S
I
H
C
D
D
V
L
N
M
V
R
Q
F
R
K
T
D
T
E
T
P
V
I
L
M
G
Y
L
N
P
I
E
Q
Y
G
Y
D
L
F
A
Q
Q
A
V
E
A
G
V
D
G
T
I
L
V
D
L
P
P
E
E
A
D
G
V
S
R
V
W
Q
K
H
G
L
Y
S
I
Y
L
C
S
P
T
T
S
A
E
R
M
N
Y
I
N
Q
H
A
N
G
Y
L
Y
Y
V
S
L
-------
A
L
K
L
P
E
L
K
A
Q
Y
L
Q
R
K
A
Q
S
K
L
P
L
M
V
G
F
G
I
K
T
P
E
M
-
A
A
Q
V
A
-
E
F
A
D
G
V
I
V
-
G
A
A
L
I
N
---------------------------------
21
PsiBlast_CBE
84.93
45%
-136
- C1 -
-
5EY5
1
?
C:
[2-261]
-
N
R
I
A
E
A
F
E
E
L
K
K
K
G
E
K
A
L
I
P
F
I
T
A
G
D
P
D
L
E
T
T
L
E
L
V
R
A
L
V
E
A
G
A
D
I
I
E
L
G
I
P
F
S
D
P
L
A
D
G
P
T
I
Q
R
A
S
Q
R
A
L
A
S
G
T
T
L
D
K
V
F
E
M
V
R
E
L
R
E
K
N
T
D
V
P
I
V
F
L
T
Y
Y
N
P
I
F
R
Y
G
I
E
R
F
V
K
E
C
A
E
A
G
V
D
G
L
I
V
P
D
L
P
P
E
E
A
A
D
L
A
A
A
A
E
K
Y
G
V
D
L
I
F
L
V
A
P
T
S
T
D
E
R
I
K
M
I
A
K
H
A
S
G
F
V
Y
C
V
S
V
T
G
V
T
---------------
R
I
R
K
H
T
D
L
P
I
A
V
G
F
G
I
S
T
P
E
Q
-
A
A
E
V
A
-
Q
V
A
D
G
V
I
V
-
G
S
A
I
V
K
R
I
E
E
N
Q
D
E
--
E
D
-
I
V
E
E
V
R
E
F
V
R
E
L
R
-------
2
PsiBlast_PDB
83.90
45%
-145
- C1 -
-
5KMY
-
TRPA_LEGPA
A:
[5-241]
-
N
R
I
D
K
T
L
E
K
L
K
A
N
R
K
K
M
L
S
P
Y
I
T
A
G
D
P
Y
P
E
L
T
V
S
L
M
H
Q
L
V
K
S
G
A
D
V
L
E
L
G
I
P
F
S
D
P
M
A
E
G
P
V
I
Q
R
A
M
E
R
A
L
A
H
S
I
H
C
D
D
V
L
N
M
V
R
Q
F
R
K
T
D
T
E
T
P
V
I
L
M
G
Y
L
N
P
I
E
Q
Y
G
Y
D
L
F
A
Q
Q
A
V
E
A
G
A
D
G
T
I
L
V
D
L
P
P
E
E
A
D
G
V
S
R
V
W
Q
K
H
G
L
Y
S
I
Y
L
C
S
P
T
T
S
A
E
R
M
N
F
I
N
Q
H
A
N
G
Y
L
Y
Y
V
S
L
-------
A
L
K
L
P
E
L
K
A
Q
Y
L
Q
R
K
A
Q
S
K
L
P
L
M
V
G
F
G
I
K
T
P
E
M
-
A
A
Q
V
A
-
E
F
A
D
G
V
I
V
-
G
A
A
L
I
N
---------------------------------
3
PsiBlast_PDB
82.22
39%
-128
- C1 -
-
2EKC
-
TRPA_AQUAE
A:
[1-262]
M
G
R
I
S
D
K
F
T
E
L
K
E
K
R
E
K
A
L
V
S
Y
L
M
V
G
Y
P
D
Y
E
T
S
L
K
A
F
K
E
V
L
K
N
G
T
D
I
L
E
I
G
F
P
F
S
D
P
V
A
D
G
P
T
I
Q
V
A
H
E
V
A
L
K
N
G
I
R
F
E
D
V
L
E
L
S
E
T
L
R
K
E
F
P
D
I
P
F
L
L
M
T
Y
Y
N
P
I
F
R
I
G
L
E
K
F
C
R
L
S
R
E
K
G
I
D
G
F
I
V
P
D
L
P
P
E
E
A
E
E
L
K
A
V
M
K
K
Y
V
L
S
F
V
P
L
G
A
P
T
S
T
R
K
R
I
K
L
I
C
E
A
A
D
E
M
T
Y
F
V
S
V
T
G
--------
Y
E
R
I
K
K
K
V
E
E
Y
R
E
L
C
D
K
P
V
V
V
G
F
G
V
S
K
K
E
H
-
A
R
E
I
G
-
S
F
A
D
G
V
V
V
-
G
S
A
L
V
K
----
L
A
G
Q
--
K
--
K
I
E
D
L
G
N
L
V
K
E
L
K
E
G
L
R
E
--
88
PsiBlast_CBE
81.71
33%
-115
- C1 -
-
1QOP
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
87
PsiBlast_CBE
81.65
33%
-114
- C1 -
-
1WBJ
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
86
PsiBlast_CBE
81.65
33%
-114
- C1 -
-
2CLK
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
76
PsiBlast_CBE
81.58
33%
-116
- C1 -
-
1K3U
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
104
Fugue
81.45
38%
-139
- C1 -
-
1GEQ
-
TRPA_PYRFU
A:
[1-248]
------
M
F
K
------
D
G
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
-----
E
I
--
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
-
V
V
S
L
L
K
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
-
G
R
--
E
--
A
T
E
F
L
K
K
K
V
E
E
L
L
G
I
-----
70
PsiBlast_CBE
81.44
33%
-115
- C1 -
-
1TJP
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
116
HHSearch
81.35
35%
-140
- C1 -
-
5TCH
2
?
E:
[10-265]
-
S
R
L
G
P
V
F
D
S
C
R
A
N
N
R
A
A
L
I
G
Y
L
P
T
G
Y
P
D
V
P
A
S
V
A
A
M
T
A
L
V
E
S
G
C
D
I
I
E
V
G
V
P
Y
S
D
P
V
M
D
G
P
T
I
A
R
A
T
E
A
A
L
R
G
G
V
R
V
R
D
T
L
A
A
V
E
A
I
S
I
A
--
G
G
R
A
V
V
M
T
Y
W
N
P
V
L
R
Y
G
V
D
A
F
A
R
D
L
A
A
A
G
G
L
G
L
I
T
P
D
L
I
P
D
E
A
Q
Q
W
L
A
A
S
E
E
H
R
L
D
R
I
F
L
V
A
P
S
S
T
P
E
R
L
A
A
T
V
E
A
S
R
G
F
V
Y
A
A
S
-----------
S
Q
A
A
P
E
L
V
G
R
V
K
A
V
S
D
I
P
V
G
V
G
L
G
V
R
S
R
A
Q
-
A
A
Q
I
A
-
Q
Y
A
D
G
V
I
V
-
G
S
A
L
V
T
A
L
T
E
---------
G
L
P
R
L
R
A
L
T
G
E
L
A
A
G
V
R
---
85
PsiBlast_CBE
81.10
33%
-117
- C1 -
-
3CEP
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
125
HHSearch
80.73
36%
-120
* C1 *
-
5CGQ
1
TRPA_SALTY
A:
[1-243]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
-
V
S
A
A
V
R
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
I
I
E
K
-----------------------------
54
PsiBlast_CBE
80.73
33%
-112
- C1 -
-
4HT3
8
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
97
PsiBlast_CBE
80.67
33%
-119
- C1 -
-
3PR2
1
TRPA_SALTY
A:
[2-258]
--
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
82
PsiBlast_CBE
80.52
33%
-113
- C1 -
-
1C29
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
47
PsiBlast_CBE
80.47
33%
-111
- C1 -
-
5CGQ
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
126
HHSearch
80.38
36%
-120
- C1 -
-
4HPX
4
TRPA_SALTY
A:
[1-243]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
-
V
S
A
A
V
R
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
I
I
E
K
-----------------------------
81
PsiBlast_CBE
80.26
33%
-113
- C1 -
-
1C8V
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
78
PsiBlast_CBE
80.22
33%
-114
- C1 -
-
1CX9
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
77
PsiBlast_CBE
80.09
33%
-118
- C1 -
-
1FUY
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
-----
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
79
PsiBlast_CBE
79.94
33%
-116
- C1 -
-
1CW2
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
84
PsiBlast_CBE
79.76
33%
-119
- C1 -
-
1A50
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
4
PsiBlast_PDB
79.70
42%
-170
- C1 -
-
1UJP
1
TRPA_THET2
A:
[7-248]
-------
F
A
K
A
R
S
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
P
Y
-
A
D
L
L
E
I
G
L
P
Y
S
D
----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
L
T
-
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
T
S
T
D
A
R
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
V
------------
E
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
S
G
K
A
T
-
A
A
Q
A
--
A
V
A
D
G
V
V
V
-
G
S
A
L
V
R
A
L
-------------------------------
80
PsiBlast_CBE
79.61
33%
-114
- C1 -
-
1C9D
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
67
PsiBlast_CBE
79.60
33%
-122
- C1 -
-
2CLH
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
72
PsiBlast_CBE
79.49
33%
-123
- C1 -
-
1K8Z
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-----------
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
53
PsiBlast_CBE
79.46
33%
-109
- C1 -
-
4KKX
5
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
59
PsiBlast_CBE
79.29
33%
-120
- C1 -
-
2TRS
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
49
PsiBlast_CBE
79.18
33%
-117
- C1 -
-
4ZQC
5
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
65
PsiBlast_CBE
79.00
33%
-121
- C1 -
-
2CLL
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
62
PsiBlast_CBE
78.85
33%
-115
- C1 -
-
2J9X
2
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
---
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
71
PsiBlast_CBE
78.84
33%
-125
- C1 -
-
1QOQ
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
63
PsiBlast_CBE
78.79
33%
-121
- C1 -
-
2CLO
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
75
PsiBlast_CBE
78.60
33%
-124
- C1 -
-
1K7E
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
-------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
74
PsiBlast_CBE
78.57
33%
-128
- C1 -
-
1K7F
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
58
PsiBlast_CBE
78.50
33%
-116
- C1 -
-
2TSY
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
50
PsiBlast_CBE
78.42
33%
-121
- C1 -
-
4Y6G
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
-----------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
83
PsiBlast_CBE
78.38
33%
-118
- C1 -
-
1A5S
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
--------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
61
PsiBlast_CBE
78.31
33%
-126
- C1 -
-
2RH9
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
73
PsiBlast_CBE
78.12
33%
-127
- C1 -
-
1K8Y
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-------------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
5
PsiBlast_PDB
77.70
42%
-169
- C1 -
-
1WXJ
1
TRPA_THET2
A:
[7-236]
-------
F
A
K
A
R
S
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
P
Y
-
A
D
L
L
E
I
G
L
P
Y
S
-----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
L
T
-
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
T
S
T
D
A
R
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
-------------
E
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
S
G
K
A
T
-
A
A
Q
A
--
A
V
A
D
G
V
V
V
-
G
S
A
L
V
R
A
L
-------------------------------
60
PsiBlast_CBE
77.21
33%
-125
- C1 -
-
2RHG
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-----------------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
124
HHSearch
77.18
35%
-113
- C1 -
-
3NAV
1
TRPA_VIBCH
A:
[4-269]
M
N
R
Y
Q
A
L
F
Q
R
L
S
A
A
Q
Q
G
A
F
V
P
F
V
T
I
G
D
P
N
P
E
Q
S
L
A
I
M
Q
T
L
I
D
A
G
A
D
A
L
E
L
G
M
P
F
S
D
P
L
A
D
G
P
T
I
Q
G
A
N
L
R
A
L
A
A
K
T
T
P
D
I
C
F
E
L
I
A
Q
I
R
A
R
N
P
E
T
P
I
G
L
L
M
Y
A
N
L
V
Y
A
R
G
I
D
D
F
Y
Q
R
C
Q
K
A
G
V
D
S
V
L
I
A
D
V
P
T
N
E
S
Q
P
F
V
A
A
A
E
K
F
G
I
Q
P
I
F
I
A
P
P
T
A
S
D
E
T
L
R
A
V
A
Q
L
G
K
G
Y
T
Y
L
L
S
R
A
--------
A
N
M
P
V
H
A
L
L
E
R
L
Q
Q
F
D
A
P
P
A
L
L
G
F
G
I
S
E
P
A
Q
-
V
K
Q
A
I
E
A
G
A
A
G
A
I
S
-
G
S
A
V
V
K
I
I
E
T
H
L
D
N
P
A
K
--
Q
L
T
E
L
A
N
F
T
Q
A
M
K
K
A
T
----
69
PsiBlast_CBE
76.97
33%
-124
- C1 -
-
2CLE
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
99
PsiBlast_CBE
76.96
33%
-122
- C1 -
-
1KFB
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
-------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
52
PsiBlast_CBE
76.89
33%
-124
- C1 -
-
4WX2
2
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
68
PsiBlast_CBE
76.65
33%
-123
- C1 -
-
2CLF
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
48
PsiBlast_CBE
76.41
33%
-126
- C1 -
-
5BW6
1
TRPA_SALTY
A:
[1-259]
M
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
-------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
64
PsiBlast_CBE
76.38
33%
-126
- C1 -
-
2CLM
1
TRPA_SALTY
A:
[2-259]
-
E
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
G
A
A
G
A
I
S
-
G
S
A
I
V
K
-------------
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
93
PsiBlast_CBE
73.19
32%
-130
- C1 -
-
1WQ5
3
TRPA_ECOLI
B:
[1-259]
M
E
R
Y
E
S
L
F
A
Q
L
K
E
R
K
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
E
A
G
A
D
A
L
E
L
G
I
P
F
S
D
P
L
-----
I
Q
N
A
T
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
Q
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
K
G
I
D
E
F
Y
A
Q
C
E
K
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
V
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
I
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
A
G
V
T
--
E
N
R
A
A
L
P
L
N
H
L
V
A
K
L
K
E
Y
N
A
A
P
P
L
Q
G
F
G
I
S
A
P
D
Q
-
V
K
A
A
I
-
D
A
G
A
A
G
A
I
S
G
S
A
I
V
K
-------------
I
I
E
Q
H
I
N
E
P
E
K
M
L
A
A
L
K
V
F
V
11
PsiBlast_PDB
68.45
36%
-132
- C1 -
-
3NAV
1
TRPA_VIBCH
A:
[4-224]
M
N
R
Y
Q
A
L
F
Q
R
L
S
A
A
Q
Q
G
A
F
V
P
F
V
T
I
G
D
P
N
P
E
Q
S
L
A
I
M
Q
T
L
I
D
A
G
A
D
A
L
E
L
G
M
P
F
S
D
P
L
A
D
G
P
T
I
Q
G
A
N
L
R
A
L
A
A
K
T
T
P
D
I
C
F
E
L
I
A
Q
I
R
A
R
N
P
E
T
P
I
G
L
L
M
Y
A
N
L
V
Y
A
R
G
I
D
D
F
Y
Q
R
C
Q
K
A
G
V
D
S
V
L
I
A
D
V
P
T
N
E
S
Q
P
F
V
A
A
A
E
K
F
G
I
Q
P
I
F
I
A
P
P
T
A
S
D
E
T
L
R
A
V
A
Q
L
G
K
G
Y
T
Y
L
L
S
R
A
--------
A
N
M
P
V
H
A
L
L
E
R
L
Q
Q
F
D
A
P
P
A
L
L
G
F
G
I
S
E
P
A
Q
-
V
K
----------------------------------------------------