@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS46: (2017-12-06 )
MSFVPQIKIPATYMRGGTSKGVFFKLDDLPEKAQVAGQARDQLLLRVIGSPDPYGKQIDGMGGATSSTSKTVILAKSTQPDHDVDYLFGQVSIDQAFVDWSGNCGNLTAAVGSFAISNGLVDADRIPENGLCTVRIWQKNIQKTIIAHVPITNGQVQETGDFELDGVTFPAAEVQIEFLDPADDGEEGGDMFPTGNVVDQLDVPEIGSFQATFINAGIPTIFLNAEDLGYEGTELQDHINGDAAALARFEKIRAYGAVQMGLIKDISEAAARQHTPKIAFVSKPKNYTASSGKNVSENDVDLLVRALSMGKLHHAMMGTAAVAIGTAAAIPGTLVNLAAGGGEREAVRFGHPSGTLRVGAQAELTNGQWVVKKAIMSRSARVLMEGWVRIPGDSS
Atome Classification :
(20 SA)
---.......---------..10........20---.....-------------------....30........--------40.......-------------.50........60........70........80........90...-----.....100--....-....110..---------.....120........130.......140--........150.........-160.......170........------180-.......190.-----......200-----------------.......210....---...220...-----...-------------.230.......240.......250....----------------...260.......270....-...---.280.......-290....-...300------.......310.......320.......----------------330.....-...340-...----------....350.......360-------........370.......380...---....390...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSFVPQI---------KI
P
A
T
Y
MRGGTSK----
G
V
F
F
K-------------------LDDL
P
E
K
A
Q
V
A
G
Q
A
--------
R
D
Q
L
L
L
R
VI-------------GSPDPYGKQIDGMGGATSST
S
K
T
V
I
L
A
KSTQPDH
D
V
D
Y
L
F
GQ
V
S
I
D
-----
Q
A
F
VDWS---GNCG-
N
L
T
A
A
V
G
S
F
---------
A
ISNGL-V
D
A
DRIPENG
L
C
T
V
R
I
W
Q
K
N
I
---
Q
K
T
I
I
A
HVP--ITNG
Q
V
QET-GDFELD
G
V
TFP-A
A
E
V
Q
I
E
F
L------DPA-DDGEEGGDMFP-----TGNVVDQLD-----------------VPEIGS
F
Q
A
T
F
INA---GI
P
T
I
F
LN
A
-----
E
DL-------------GYEG
T
E
L
Q
D
HIN
G
D
A
A
A
L
A
R
F
E
K
I
R
A
YG----------------
A
V
Q
M
G
L
I
K
D
I
S
E
A
A
A
-RQHT-P
K
I
---
A
F
V
SKPKNYTA-SSGKNVS-
E
N
D
V
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
MG
T
A
A
V
AIGTAAA----------------I-PG
T
L
V
N
-LAAGGG-ER
E
----------
A
V
R
FGHPSG
T
L
R
VG
A
Q
--------
A
ELTN
G
Q
W
V
V
K
K
A
I
M
S
R
S
A
R
V
L
M
E
---
G
WVRIPGDSS
11
HHSearch
90.31
81%
-64
- C4 -
-
5K87
-
?
A:
[7-398]
----
L
F
P
P
Q
I
---------
K
V
A
A
T
Y
M
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
Q
D
L
P
E
A
A
Q
V
P
G
P
A
--------
R
D
A
L
L
L
R
V
I
-------------
G
S
P
D
P
Y
A
K
Q
I
D
G
M
G
G
A
T
S
S
T
S
E
T
V
I
L
S
H
S
S
K
A
N
H
D
V
D
Y
L
F
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
T
A
A
V
G
A
F
---------
A
I
S
N
G
L
-
I
D
A
A
R
I
P
R
N
G
V
C
T
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
I
T
D
G
A
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
V
Q
I
E
F
M
------
N
P
A
-
A
D
---
G
G
C
M
F
P
-----
T
G
N
L
V
D
V
L
E
-----------------
V
P
G
I
G
R
F
N
A
T
M
I
N
A
---
G
I
P
T
I
F
I
N
A
-----
E
D
L
-------------
G
Y
T
G
T
E
L
Q
D
D
I
N
S
D
N
A
A
L
A
K
F
E
T
I
R
A
H
G
----------------
A
L
R
M
G
L
I
K
H
I
D
E
A
A
S
-
R
Q
H
T
-
P
K
I
---
A
F
V
A
P
P
K
S
Y
A
S
-
S
S
-
G
K
T
V
A
A
E
D
V
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
K
E
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
Q
--------
A
V
Q
E
N
G
E
W
T
V
I
K
A
I
M
S
R
S
A
R
V
L
M
E
---
G
F
V
R
V
P
K
---
10
HHSearch
88.86
74%
-98
- C4 -
-
2H9F
2
?
A:
[2-396]
---
M
A
H
P
P
Q
I
---------
R
I
P
A
T
Y
L
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
E
D
L
P
E
S
C
R
V
P
G
E
A
--------
R
D
R
L
F
M
R
V
I
-------------
G
S
P
D
P
Y
A
A
H
I
D
G
M
G
G
A
T
S
S
T
S
K
C
V
I
L
S
K
S
S
Q
P
G
H
D
V
D
Y
L
Y
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
S
T
G
A
G
A
F
---------
A
L
H
A
G
L
-
V
D
P
A
R
I
P
E
D
G
I
C
E
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
V
S
G
G
Q
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
I
V
L
E
F
L
------
D
P
S
-
D
----
G
G
A
I
F
P
-----
T
G
N
L
V
D
D
L
E
-----------------
V
P
G
V
G
T
F
K
A
T
M
I
N
A
---
G
I
P
T
V
F
V
N
A
-----
E
E
I
-------------
G
Y
R
G
T
E
L
R
E
E
I
N
G
D
P
Q
Q
L
A
R
F
E
R
I
R
V
A
G
----------------
A
L
R
M
G
L
I
K
T
P
E
E
A
A
T
-
R
Q
H
T
-
P
K
I
---
A
F
V
A
P
P
R
D
Y
R
T
-
A
S
G
K
L
V
A
-
A
G
D
I
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
R
S
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
E
--------
A
S
Q
A
N
G
E
W
T
V
T
K
A
I
M
S
R
S
A
R
I
L
M
E
---
G
W
V
R
V
P
G
D
A
F
3
PsiBlast_PDB
88.37
73%
-98
- C4 -
-
2H9F
2
?
A:
[6-395]
-------
P
Q
I
---------
R
I
P
A
T
Y
L
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
E
D
L
P
E
S
C
R
V
P
G
E
A
--------
R
D
R
L
F
M
R
V
I
-------------
G
S
P
D
P
Y
A
A
H
I
D
G
M
G
G
A
T
S
S
T
S
K
C
V
I
L
S
K
S
S
Q
P
G
H
D
V
D
Y
L
Y
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
S
T
G
A
G
A
F
---------
A
L
H
A
G
L
-
V
D
P
A
R
I
P
E
D
G
I
C
E
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
V
S
G
G
Q
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
I
V
L
E
F
L
------
D
P
S
-----
D
G
G
A
I
F
P
-----
T
G
N
L
V
D
D
L
E
-----------------
V
P
G
V
G
T
F
K
A
T
M
I
N
A
---
G
I
P
T
V
F
V
N
A
-----
E
E
I
-------------
G
Y
R
G
T
E
L
R
E
E
I
N
G
D
P
Q
Q
L
A
R
F
E
R
I
R
V
A
G
----------------
A
L
R
M
G
L
I
K
T
P
E
E
A
A
T
-
R
Q
H
T
-
P
K
I
---
A
F
V
A
P
P
R
D
Y
R
T
-
A
S
G
K
L
V
A
-
A
G
D
I
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
R
S
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
E
--------
A
S
Q
A
N
G
E
W
T
V
T
K
A
I
M
S
R
S
A
R
I
L
M
E
---
G
W
V
R
V
P
G
D
A
-
2
PsiBlast_PDB
88.31
81%
-41
- C4 -
-
5K87
-
?
A:
[8-397]
-----
F
P
P
Q
I
---------
K
V
A
A
T
Y
M
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
Q
D
L
P
E
A
A
Q
V
P
G
P
A
--------
R
D
A
L
L
L
R
V
I
-------------
G
S
P
D
P
Y
A
K
Q
I
D
G
M
G
G
A
T
S
S
T
S
E
T
V
I
L
S
H
S
S
K
A
N
H
D
V
D
Y
L
F
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
T
A
A
V
G
A
F
---------
A
I
S
N
G
L
-
I
D
A
A
R
I
P
R
N
G
V
C
T
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
I
T
D
G
A
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
V
Q
I
E
F
M
------
N
P
A
A
D
----
G
G
C
M
F
P
-----
T
G
N
L
V
D
V
L
E
-----------------
V
P
G
I
G
R
F
N
A
T
M
I
N
A
---
G
I
P
T
I
F
I
N
A
-----
E
D
L
-------------
G
Y
T
G
T
E
L
Q
D
D
I
N
S
D
N
A
A
L
A
K
F
E
T
I
R
A
H
G
----------------
A
L
R
M
G
L
I
K
H
I
D
E
A
A
S
-
R
Q
H
T
-
P
K
I
---
A
F
V
A
P
P
K
S
Y
A
S
-
S
S
G
K
T
V
A
-
A
E
D
V
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
K
E
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
Q
--------
A
V
Q
E
N
G
E
W
T
V
I
K
A
I
M
S
R
S
A
R
V
L
M
E
---
G
F
V
R
V
P
----
1
PsiBlast_PDB
88.29
81%
-43
- C4 -
-
2PW0
4
PRPF_SHEON
A:
[6-395]
-----
F
P
P
Q
I
---------
K
V
A
A
T
Y
M
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
Q
D
L
P
E
A
A
Q
V
P
G
P
A
--------
R
D
A
L
L
L
R
V
I
-------------
G
S
P
D
P
Y
A
K
Q
I
D
G
M
G
G
A
T
S
S
T
S
K
T
V
I
L
S
H
S
S
K
A
N
H
D
V
D
Y
L
F
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
T
A
A
V
G
A
F
---------
A
I
S
N
G
L
-
I
D
A
A
R
I
P
R
N
G
V
C
T
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
I
T
D
G
A
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
V
Q
I
E
F
M
------
N
P
A
A
D
-------
M
F
P
-----
T
G
N
L
V
D
V
L
E
-----------------
V
P
G
I
G
R
F
N
A
T
M
I
N
A
---
G
I
P
T
I
F
I
N
A
-----
E
D
L
-------------
G
Y
T
G
T
E
L
Q
D
D
I
N
S
D
N
A
A
L
A
K
F
E
T
I
R
A
H
G
----------------
A
L
R
M
G
L
I
K
H
I
D
E
A
A
S
-
R
Q
H
T
-
P
K
I
---
A
F
V
A
P
P
K
S
Y
A
S
-
S
S
G
K
T
V
A
-
A
E
D
V
D
L
------
L
V
R
A
L
S
M
G
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
K
E
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
Q
--------
A
V
Q
E
N
G
E
W
T
V
I
K
A
I
M
S
R
S
A
R
V
L
M
E
---
G
F
V
R
V
P
----
9
PsiBlast_CBE
81.88
81%
-58
- C4 -
-
2PW0
4
PRPF_SHEON
B:
[6-395]
-----
F
P
P
Q
I
---------
K
V
A
A
T
Y
M
R
G
G
T
S
K
----
G
V
F
F
R
-------------------
L
Q
D
L
P
E
A
A
Q
V
P
G
P
A
--------
R
D
A
L
L
L
R
V
I
-------------
G
S
P
D
P
Y
A
K
Q
I
D
G
M
G
G
A
T
S
S
T
S
K
T
V
I
L
S
H
S
S
K
A
N
H
D
V
D
Y
L
F
G
Q
V
S
I
D
-----
K
P
F
V
D
W
S
---
G
N
C
G
-
N
L
T
A
A
V
G
A
F
---------
A
I
S
N
G
L
-
I
D
A
A
R
I
P
R
N
G
V
C
T
V
R
I
W
Q
A
N
I
---
G
K
T
I
I
A
H
V
P
--
I
T
D
G
A
V
Q
E
T
-
G
D
F
E
L
D
G
V
T
F
P
-
A
A
E
V
Q
I
E
F
M
------
N
P
A
A
D
------
C
M
F
P
-----
T
G
N
L
V
D
V
--------------------------
N
A
T
M
I
-
A
---
G
I
P
T
I
F
I
N
A
-----
E
D
L
-------------
G
Y
T
G
T
E
L
Q
D
D
I
N
S
D
----------------------------------------------------
K
I
---
A
F
V
A
P
P
K
S
Y
A
S
-
S
S
G
K
T
V
A
-
A
E
D
V
D
L
------
L
V
R
A
L
---
K
L
H
H
A
M
M
G
T
A
A
V
A
I
G
T
A
A
A
----------------
I
-
P
G
T
L
V
N
-
L
A
A
G
G
G
-
E
K
E
----------
A
V
R
F
G
H
P
S
G
T
L
R
V
G
A
Q
--------
A
V
Q
E
N
G
E
W
T
V
I
K
A
I
M
S
R
S
A
R
V
L
M
E
---
G
F
V
R
V
P
----
12
HHSearch
72.67
42%
-61
- C4 -
-
3G7K
-
MII_EUBBA
D:
[2-378]
------
S
D
Q
M
---------
R
I
P
C
V
I
M
R
A
G
T
S
K
----
G
I
F
L
K
-------------------
G
N
D
L
P
A
D
----
Q
E
L
--------
R
D
K
V
I
L
R
I
F
-------------
G
S
P
D
V
--
R
Q
I
D
G
L
A
G
A
D
P
L
T
S
K
L
A
I
I
G
P
S
T
H
P
D
A
D
V
D
Y
T
F
A
Q
V
S
I
T
-----
D
A
V
V
D
Y
N
---
G
N
C
G
-
N
I
S
A
G
V
G
P
F
---------
A
I
D
E
S
F
-
V
K
A
----
V
E
P
M
T
R
V
C
I
H
N
T
N
T
---
G
K
L
L
Y
A
E
V
E
--
V
E
D
G
K
A
K
V
S
-
G
D
C
K
I
D
G
V
P
G
T
-
N
A
P
E
L
M
D
F
S
------
D
T
A
-
G
A
--
A
T
G
K
V
L
P
-----
T
G
N
V
V
D
V
L
S
-----------------
T
S
K
-
G
D
I
D
V
S
I
V
D
V
---
A
N
P
C
I
F
V
H
A
-----
K
D
V
-------------
N
M
T
G
T
E
T
P
D
V
I
N
G
N
A
D
L
L
A
Y
L
E
E
I
R
A
K
C
----------------
C
V
K
I
G
M
A
A
T
E
K
E
A
S
E
K
S
P
A
F
-
P
M
I
---
A
F
V
T
K
P
E
D
Y
V
D
-
F
S
T
G
N
T
I
S
G
D
D
V
D
L
------
V
S
R
L
M
F
M
Q
V
L
H
K
T
Y
A
G
T
A
T
A
C
T
G
S
A
A
R
----------------
I
-
P
G
T
I
V
N
-
Q
V
L
R
D
T
G
D
E
D
----------
T
V
R
I
G
H
P
A
G
V
I
P
V
V
S
I
--------
V
K
----
D
G
K
V
E
K
A
A
L
I
R
T
A
R
R
I
M
E
---
G
Y
V
Y
V
E
K
A
K
-
13
HHSearch
72.30
42%
-60
- C4 -
-
3G7K
-
MII_EUBBA
B:
[2-378]
------
S
D
Q
M
---------
R
I
P
C
V
I
M
R
A
G
T
S
K
----
G
I
F
L
K
-------------------
G
N
D
L
P
A
D
----
Q
E
L
--------
R
D
K
V
I
L
R
I
F
-------------
G
S
P
D
V
--
R
Q
I
D
G
L
A
G
A
D
P
L
T
S
K
L
A
I
I
G
P
S
T
H
P
D
A
D
V
D
Y
T
F
A
Q
V
S
I
T
-----
D
A
V
V
D
Y
N
---
G
N
C
G
-
N
I
S
A
G
V
G
P
F
---------
A
I
D
E
S
F
-
V
K
A
----
V
E
P
M
T
R
V
C
I
H
N
T
N
T
---
G
K
L
L
Y
A
E
V
E
--
V
E
D
G
K
A
K
V
S
-
G
D
C
K
I
D
G
V
P
G
T
-
N
A
P
E
L
M
D
F
S
------
D
T
A
-
G
A
--
A
T
G
K
V
L
P
-----
T
G
N
V
V
D
V
L
S
-----------------
T
S
K
-
G
D
I
D
V
S
I
V
D
V
---
A
N
P
C
I
F
V
H
A
-----
K
D
V
-------------
N
M
T
G
T
E
T
P
D
V
I
N
G
N
A
D
L
L
A
Y
L
E
E
I
R
A
K
C
----------------
C
V
K
I
G
M
A
A
T
E
K
E
A
S
E
K
S
P
A
F
-
P
M
I
---
A
F
V
T
K
P
E
D
Y
V
D
-
F
S
T
G
N
T
I
S
G
D
D
V
D
L
------
V
S
R
L
M
F
M
Q
V
L
H
K
T
Y
A
G
T
A
T
A
C
T
G
S
A
A
R
----------------
I
-
P
G
T
I
V
N
-
Q
V
L
R
D
T
G
D
E
D
----------
T
V
R
I
G
H
P
A
G
V
I
P
V
V
S
I
--------
V
K
----
D
G
K
V
E
K
A
A
L
I
R
T
A
R
R
I
M
E
---
G
Y
V
Y
V
E
K
A
K
-
4
PsiBlast_PDB
71.02
42%
-50
- C4 -
-
3G7K
-
MII_EUBBA
A:
[4-374]
--------
Q
M
---------
R
I
P
C
V
I
M
R
A
G
T
S
K
----
G
I
F
L
K
-------------------
G
N
D
L
P
A
D
Q
E
L
------------
R
D
K
V
I
L
R
I
F
-------------
G
S
P
D
V
--
R
Q
I
D
G
L
A
G
A
D
P
L
T
S
K
L
A
I
I
G
P
S
T
H
P
D
A
D
V
D
Y
T
F
A
Q
V
S
I
T
-----
D
A
V
V
D
Y
N
---
G
N
C
G
-
N
I
S
A
G
V
G
P
F
---------
A
I
D
E
S
F
-
V
K
A
V
E
-
P
M
T
R
V
C
---
I
H
N
T
N
T
---
G
K
L
L
Y
A
E
V
E
--
V
E
D
G
K
A
K
V
S
-
G
D
C
K
I
D
G
V
P
G
T
-
N
A
P
E
L
M
D
F
S
------
D
T
A
---
G
A
A
T
G
K
V
L
P
-----
T
G
N
V
V
D
V
L
S
-----------------
T
S
K
-
G
D
I
D
V
S
I
V
D
V
---
A
N
P
C
I
F
V
H
A
-----
K
D
V
-------------
N
M
T
G
T
E
T
P
D
V
I
N
G
N
A
D
L
L
A
Y
L
E
E
I
R
A
K
C
----------------
C
V
K
I
G
M
A
A
T
E
K
E
A
S
E
-
K
S
P
A
F
P
M
I
---
A
F
V
T
K
P
E
D
Y
V
D
F
S
T
G
N
T
I
S
-
G
D
D
V
D
L
------
V
S
R
L
M
F
M
Q
V
L
H
K
T
Y
A
G
T
A
T
A
C
T
G
S
A
A
R
----------------
I
-
P
G
T
I
V
N
Q
V
L
R
D
T
G
-
D
E
D
----------
T
V
R
I
G
H
P
A
G
V
I
P
V
--
V
--------
S
I
V
K
D
G
K
--
V
E
K
A
A
L
I
R
T
A
R
R
I
M
E
---
G
Y
V
Y
V
-----
34
Fugue
33.67
21%
14
* C5 *
-
3ZK4
8
?
A:
[3-571]
H
A
Y
I
K
A
T
P
N
V
LGFEGHY
T
E
W
V
T
L
Q
Y
S
N
N
K
P
S
I
D
D
W
I
G
V
F
S
P
ANFSASTCPGENKMTNPPF
L
C
S
A
P
I
K
F
Q
Y
A
N
F
S
SHSYKDTG
K
G
S
L
K
L
Q
L
I
NQ
R
S
D
F
S
F
A
L
F
T
G
G
L
T
N
P
--
K
L
I
A
V
S
N
K
V
S
F
V
N
P
N
A
P
V
Y
P
R
L
A
Q
G
K
T
W
D
E
I
T
V
T
W
T
S
G
Y
DIND
A
E
P
F
V
E
W
G
PKE
G
N
L
V
-
K
T
P
A
G
T
L
T
F
D
RNTMCGAP
A
R
T
V
G
W
-
R
D
P
G
Y
I
H
T
S
F
L
---
K
E
L
W
P
N
R
---
E
Y
T
Y
K
L
G
H
R
--
L
F
N
G
T
T
I
W
S
-
K
E
Y
H
F
K
A
S
P
Y
P
G
Q
S
S
V
Q
R
V
V
I
F
G
DM
G
K
A
E
A
-
D
G
S
N
E
Y
N
N
F
Q
P
G
S
L
N
T
T
K
Q
I
I
Q
D
L
E
DIDIVFHIGDLCYANGY
I
S
Q
W
D
Q
F
T
A
Q
I
E
P
I
---
A
S
T
V
P
Y
M
T
A
S
G
NHE
R
D
W
P
GTGSFYGNLDSG
G
E
C
G
V
P
A
Q
T
M
F
F
V
P
A
E
N
R
E
K
F
W
Y
S
T
D
Y
G
M
F
R
F
C
I
A
H
TELDWRKG
T
E
Q
Y
E
F
I
E
K
C
L
A
S
V
D
-
R
Q
K
Q
-
P
W
L
---
I
F
L
A
H
R
V
L
G
Y
S
-
S
A
G
F
Y
V
Q
-
E
G
S
F
E
E
PMGR
E
D
L
Q
H
L
W
Q
K
Y
K
V
D
I
A
M
Y
G
H
V
H
N
Y
E
R
T
C
P
I
YQNVCTNKEKHNYKGN
L
-
N
G
T
I
H
V
-
V
V
G
G
G
G
-
A
S
L
A
E
F
A
PINTTW
S
I
F
K
D
H
D
F
G
F
V
K
L
T
A
F
DHS
N
L
L
L
E
Y
R
K
S
S
D
G
Q
V
Y
D
S
F
T
I
S
R
D
Y
R
D
I
L
A
CSV
D
S
C
P
T
T
T
L
A
S
27
HHSearch
32.31
18%
-145
- C4 -
-
2Q9H
-
DAPF_HAEIN
A:
[199-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
I
------
K
L
R
V
Y
E
R
G
A
G
E
T
Q
A
C
G
S
G
A
C
A
A
V
A
V
G
I
----------------
M
-
Q
G
L
L
----------
N
-
N
----------
N
V
Q
V
D
L
P
G
G
S
L
M
I
E
W
N
--------
G
V
-------
G
H
P
L
Y
M
T
G
E
A
T
H
I
Y
D
---
G
F
I
T
L
-----
18
HHSearch
32.16
13%
-182
- C4 -
-
4JBD
1
4HYPE_PSEP1
A:
[93-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
T
C
------
G
V
I
F
F
N
N
A
G
Y
-
L
N
M
C
G
H
G
T
I
G
L
V
A
S
L
Q
----------------
H
-
L
G
L
I
A
----------
P
G
----------
V
H
K
I
D
T
P
V
G
Q
V
S
A
T
L
H
---------------------------------------------
23
HHSearch
32.12
19%
-154
* C4 *
-
2OTN
-
DAPF_BACAN
A:
[208-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
M
------
N
F
R
V
W
E
R
G
S
G
V
T
Q
A
C
G
T
G
A
C
A
A
V
V
A
S
I
----------------
L
-
N
G
K
M
E
---------
R
G
K
----------
E
I
T
V
H
L
A
G
G
D
L
M
I
A
W
T
--------
E
E
--------
G
N
V
L
M
K
G
P
A
E
V
I
C
R
---
G
V
Y
E
Y
K
I
E
--
29
HHSearch
31.57
19%
-136
- C4 -
-
5HA4
-
DAPF_ACIB3
B:
[204-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
H
V
------
R
L
R
V
F
E
R
G
V
G
E
T
L
A
C
G
T
G
A
C
A
A
A
V
S
G
M
----------------
R
-
R
G
L
L
-----------
A
N
----------
S
V
E
V
E
L
A
G
G
K
L
Q
I
E
W
Q
--------
E
G
--------
D
V
V
W
M
T
G
P
T
T
H
V
Y
D
---
G
R
L
D
L
R
Y
---
30
HHSearch
30.97
19%
-133
- C4 -
-
5HA4
1
DAPF_ACIB3
A:
[204-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
H
V
------
R
L
R
V
F
E
R
G
V
G
E
T
L
A
C
G
T
G
A
C
A
A
A
V
S
G
M
----------------
R
-
R
G
L
L
-----------
A
N
----------
S
V
E
V
E
L
A
G
G
K
L
Q
I
E
W
Q
--------
E
G
--------
D
V
V
W
M
T
G
P
T
T
H
V
Y
D
---
G
R
L
D
L
R
Y
---
16
HHSearch
26.18
17%
-11
- C4 -
-
4JUU
-
4HYPE_XANCP
A:
[23-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
T
I
D
V
I
D
S
H
T
A
G
E
P
T
R
V
V
L
A
-----
G
F
P
-------------
D
L
G
D
-
G
D
L
--
A
Q
C
R
E
R
F
R
S
D
F
D
H
W
R
S
A
I
----------------
A
C
E
P
R
G
---------------
S
D
T
M
V
G
A
L
L
L
P
P
R
D
-------------
P
S
A
C
T
------
G
V
I
F
F
N
N
V
G
-
Y
L
G
M
C
G
H
G
T
I
G
V
V
R
T
L
A
----------------
E
-
L
G
R
I
A
----------
P
G
----------
Q
H
R
I
E
T
P
V
G
T
V
G
V
A
L
----------------------------------------------
36
Fugue
25.72
21%
-16
- C1 -
-
5L45
1
?
B:
[19-299]
-------
S
H
M
---------
K
I
L
V
T
G
A
R
G
S
I
G
S
----
R
V
A
G
K
-------------------
L
V
E
--
R
G
L
P
V
R
G
G
V
--------
R
D
---
L
A
A
P
-------------
G
L
P
E
-------
G
V
E
A
V
Q
A
D
L
T
R
P
E
T
L
A
R
A
L
-
E
G
V
D
K
V
F
L
Y
T
V
P
E
G
I
-----
A
G
F
V
D
E
A
---
R
A
A
G
V
R
H
V
V
L
L
S
S
I
---------
A
V
T
--------------------
W
P
D
A
D
---
R
D
P
I
G
R
M
H
L
--
A
V
E
R
P
I
E
E
S
-
G
--------------
L
G
W
T
F
V
------
R
P
E
-
A
L
A
T
N
A
L
G
W
A
P
-----
E
I
R
G
G
D
M
V
R
-----------------
C
A
Y
P
G
A
Y
T
T
P
V
H
E
E
---
D
I
A
D
V
V
V
A
A
-----
L
T
---------------------
T
P
G
H
R
S
A
A
Y
A
L
T
G
P
E
T
L
T
---------------------
Q
A
E
Q
V
A
L
I
G
E
A
L
G
-
R
--------------------
A
-
V
R
C
E
R
M
P
-
E
Q
E
A
R
A
------
V
L
E
G
L
Y
P
A
E
V
V
D
A
I
L
A
G
Q
A
A
R
D
G
R
P
A
E
----------------
V
-
L
D
T
I
R
A
-
V
T
----------------------
G
R
P
A
R
T
F
R
E
W
A
G
--------
D
H
V
A
A
F
R
P
-----------------------------
35
Fugue
25.66
29%
1
- C5 -
-
1ZLD
-
?
A:
[2-118]
---------------------------------------------------------------------------------------------------------------------------------------------
G
N
I
G
Q
V
D
I
D
-----
S
V
I
L
G
R
P
---
G
--------
A
I
G
S
W
---------
E
L
N
N
F
I
T
I
G
L
N
R
V
N
A
D
---
T
V
R
V
N
I
R
N
T
G
R
T
N
R
L
I
I
T
Q
W
D
N
T
V
T
R
G
D
V
Y
E
L
F
G
D
Y
A
L
-----
I
-
Q
G
R
G
S
F
C
L
N
------
I
R
S
-
D
T
G
R
E
N
W
R
M
Q
L
-----
E
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
24.58
21%
-113
- C4 -
-
1PQH
3
PAND_ECOLI
A:
[32-82]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-----
H
A
D
L
H
Y
E
---
G
T
C
--------------------
A
I
D
Q
D
F
-
L
D
A
A
G
I
--
L
E
N
E
A
I
D
I
W
N
V
T
N
---
G
K
R
F
S
-----------------
T
Y
A
I
A
A
E
R
G
S
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
23.37
22%
-52
- C4 -
-
5H2G
-
DAPF_CORGL
B:
[203-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
V
------
S
M
R
V
W
E
R
G
V
G
E
T
R
S
C
G
T
G
T
V
A
A
A
C
A
A
L
----------------
A
D
A
G
L
G
-----------
E
G
----------
T
V
K
V
C
V
P
G
G
E
V
E
V
Q
I
F
--------
D
---------
D
G
S
T
L
T
G
P
S
A
I
I
A
L
---
G
E
V
Q
I
H
H
H
--