@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_07_0410: (2018-03-08 )
MSGSQLHSATAAATMTSTAVSSASAEPSPPTGSSSTAIMSSSLTALAQQQQRLLVSSLLPCDGPLQYVDPTADGLPGTSPSCSEEHNSCTRPDAAQQDRAVSMRVPHATAHERSEHASNDPGPSPPFLPAAEERLTGRSPDAADATSHLDHDGAADCATSSSSTATASTISMHITETCVLKDTLPAPPMQDQSSSEGGVDATAARYSSSPLVNAGSDATLTMTGMRSATPSSPLKAQSNSLQPKESAKVAIDAVSRGSAGQQPSASGGLTTMMTTATSTNTTTAARGLPRTMLPDTLSACTTMKGSETLSSQAGSLMLPLSDGTPPSCSMKAATAALSGPRREKRRPPSLFSSSPATTSLTVATRPVLITPAVSRQEDRSLTTSVTQTASSVSQTNQPLHGQVQRPPAPLPRTPGAPSPLSSTLVSSALPTHGDGGVEEDADGERLSTLVVRRDLHELAATRLPMNPASYAPVHVKLPAVLPTTSPPLRSGRPAHPIAAQQHRAACESQGGLTGSSGASTAAHHSAAGATTPAAIAPVSTPSSVTMFHYGSFQAGYASTAAAGGAVTPNATPLLSNSSLCGFANYCGAGSLGSGSAPAASLSTATSTACANRLQPPSAARLSVTGMGGGGGGAVAGVLSPLSLSGAAATARTVRRRAPPPLLFRLRSPVGPAPPSTAVSANDTSGEMTSPGSVAPPSSASRTATSAAAAAASAGACSSVLTTPPLNSRSMGMTMNSGSASDLASTMADRPARGSGCNPPATPARSGPFARAHGSVAQNLNTFSSSTRSGGLVRISHDRRTLVAGMFRVSRDGCLTVRNMLLLNPTRIDAGSATGGAAGPGCTCGSFMGSSTTGTGGGGSRSRPLQLLHPQRSATNYSPVSSNGGLVGRMQLLGPGGGNDLGGGGGAGGGAGGLGPMTPNTTGSDWYSPHAYHGGGGGSGNTRNDXXXXGGKRGGANTTANASFTLFSTSMDTPFSPITYSMDSQRLALPSPLGVHHDRAGAAAGPPPQLLGTVCENTATSHFLGASGSPHQQPQPHDGLLPGSHHVTETNASPTRNLGFGMVTGGAAAAAQQQVATPNSTTALGRPSGGSGGNICHAQLRRQASNGWLPGALGATNTASPPPFAAAGGAGGMLNAGAFTDTDTANSLLLPYADIPTYRGGIASATAGSRVDSPSGHTNPGGFRTTTTAATATTAAAPMMGGSGATQNTSFPPLPPNVVRLRDLDILSTTCGEGASATVFVAIHKPTGRRLAVKRVDLSPLCLGCSSPFLRSGAVSSGRINQLQRIVVRELQVLHLTYRSPFMVKVYNAFFLAEVAALDIVMEFMHYGSLDHLADCLQQHARMVRGSQQERHRLLTGDDDQDDGDGGGHSGRCGSVHGGSPSVPPLLCDAPEAPQVTEGFLKDTSAAGVGRSGTGGDTERRPSITSTSPKLLDSQRTLAERAPPSAPRPCISRVVDTTGSSDVDSIACGSGGVPCHPLTGGYKHIYGSNDSLLLDSYSVKSDCGTDDSESDDGSGLVEEPLGVTERLVAVVGEQLLRGVRDMHSRGYIHQDIKPGNVLVNEHGVVKLSDFGLSQRCDSTGLGIKNDMLTYVPPPSVAPAQSITPLQSPSLTVLPLTGARGRRAPFVWHAQRGSIGAGISGQLGSGMVGTTPPEMGSSAEGLVFSSTTNSLLAQRDGMDVLEAESTSSEEGPGEWDATRRGRSGLNPSSSSSDDAGDCCGTDKYMSPERQRGEPYGKPADIWAVGVTLAEFAVGEYPYDLKDVIDEFDRVSRMDKPVDVLQFNKHRAVPLGTVFADFCRLATLPTASQRPTAQELLEHPFFKQWHRPFNLKDYLAARVPVPSNRLKEDYLAKQRERPPEGQQPAGPPG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220.......1230......1240......1250......1260......1270......1280......1290......1300......1310----........1320......1330......1340......1350......1360......1370.....-----------.1380....-..1390......1400......1410......1420......1430......1440..--....1450......1460......1470---........1480........1490......1500......1510......1520--------........1530......--1540......1550.....----.1560---.----.--......1570--.........-------1580.-....--.1590----........1600...-------...1610......1620.......1630......1640......1650......1660......1670..----...----.1680......1690......1700......1710.......1720......------1730----.......1740......1750......1760......1770......1780......1790......1800...---.-----..1810......1820.-..-.....1830......1840....--..1850......1860...-------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSGSQLHSATA
A
A
T
M
T
S
TAVSSASAEPSPPTGSS
S
T
A
I
M
S
S
S
L
T
A
L
A
Q
Q
Q
Q
R
L
L
V
S
SLLPCDGP
L
Q
YVDPTADGLPGTSPSC
S
E
EHNSCTRPDAAQQD
R
A
V
S
M
RVPHAT
A
H
E
R
SEHASNDPGPSPPFLP
A
A
E
E
RLTGRSPDAADATSHLDHDGAADCATSSSSTA
T
A
S
T
I
S
M
H
I
T
E
T
C
V
LKDTLPAPPMQDQSSSEGGV
D
A
T
A
ARYSSSPLVNAGS
D
A
T
L
T
M
TGMRSATPSSPLKAQSNSLQPKES
A
K
V
A
I
D
A
VSRGSAGQQPSASGG
L
T
T
M
M
T
TATSTNTTTAARGLPRTM
L
P
D
T
L
S
A
C
TTMKGSE
T
L
SSQA
G
S
L
M
L
PLSDGTPPSC
S
M
K
A
A
T
A
ALSGPRREKRRPPSLFSSSPA
T
T
S
L
T
V
ATR
P
V
L
ITPAVSRQEDR
S
L
T
T
S
V
T
Q
T
A
S
S
V
SQTNQPLHGQVQRPPAPLPRTPGAPS
P
L
S
S
T
L
V
S
SALPTHGDGGVEEDAD
G
E
R
L
S
T
L
V
V
R
R
D
L
H
E
L
A
A
TRLPMNPASYA
P
V
H
V
KLPAVLPTTSPPLRSGRPAHP
I
A
A
Q
Q
H
R
A
A
C
E
SQGGLTGSSGASTAAHHSAAGATTP
A
A
IAPVSTP
S
S
V
T
M
F
H
YGSFQAGYASTAAAGGAVTPNATPLLSNSSLCGFANYCGAGSLGSGSAPAASLSTA
T
S
T
A
C
ANRLQPPSA
A
R
L
S
V
T
GMGGGG
G
G
A
V
A
G
V
LSPLSLSG
A
A
A
T
A
R
T
V
RRRAPP
P
L
L
F
R
LRSPVGPAPPSTAVSANDTSGEMTSPGSVAPPSSASRTA
T
S
A
A
A
A
AASAGACSSVLTTPPLNSRSM
G
M
T
MNSG
S
A
S
D
L
A
S
T
M
ADRPARGSGCNPPATPARSGPFARAH
G
S
V
A
Q
N
L
N
T
FSSSTRSG
G
L
V
R
ISHD
R
R
T
L
V
A
G
M
F
RVSRD
G
C
L
T
V
R
N
M
L
L
LNPTRIDAGSATGGAAGPGCT
C
G
S
FMGSSTTGTGGGGSRSR
P
L
Q
L
LHPQRSATNYSPVSSNG
G
L
V
G
R
M
Q
L
LGPGGGNDLGGGGGAGGGAGGLGPMTPNTTGSDWYSPHAYHGGGGGSGNTRNDXXXXGGKRGGANTTA
N
A
S
F
T
L
F
STSMDTPFSP
I
T
YSMDSQRLALPSPLGVHHDRAGAAAGP
P
P
Q
L
L
G
T
V
C
ENTATSHFLGASGSPHQQPQPHDGLLPGSHHVTETNASPTRNLGFGMVTGG
A
A
A
A
A
Q
QQVATPNSTTALGRPSGGSGGN
I
C
H
A
Q
L
R
R
QASNGWLPGALGATNTASPPPFAAAGGAGGMLNAGAFTDTDTAN
S
L
L
LPYADIPTYRGGIASATAGSRVDSPSGHTNPGG
F
R
T
T
T
T
AATATTAAAPMMGGSGATQNTSFPPLPP
N
V
V
R
L
R
-
D
L
D
I
L
STTCGEGA
S
A
T
V
F
V
A
I
HKPTG
R
R
L
A
V
K
RVDLS
P
L
CLGCS
S
P
F
LRSGAVSSG
R
I
N
Q
L
Q
R
I
V
V
R
E
L
Q
V
L
H
L
TYRS
P
F
M
V
K
V
Y
N
A
F
F
L
------
A
E
V
A
A
L
D
I
V
M
E
F
M
HYG
S
L
D
H
L
A
D
C
L
Q
Q
H
A
R
M
VRG
S
Q
Q
E
RHRLLTGDDDQDDGDGGGHSGRCGSVHGG-----------SPSVPPLLC-DAPEAP
Q
V
T
E
G
F
L
KDTSAAGVGRSGTGGDTERRPSITSTS
P
K
L
L
D
S
Q
R
T
L
A
ERAPPSA--
P
R
P
C
I
S
R
V
V
DTTGSSDV
D
S
IACGSGG-----VPCHPLTGG--YK
H
I
YGSND
S
L
L
L
D
S
Y
SVKSDCGTDDSESDDGSGLVEEPL
G
----------
V
T
E
R
L
V
A
V
V
G
E
Q
L
L
R
G
V
R
--
D
M
H
SRG
Y
I
HQDIKPG
N
V
L
V----NE--H---
G
----
V
--
V
K
L
SDFG-----LSQRCDSTG-------LGIKN-D
M
L
T
--YVP------PPSVAPAQSITPLQS-------P
S
L
T
V
L
PLTGARGRR-A
P
F
V
W
H
AQRGSIGAGISGQLGSGMVGTTPPEMGSSAE
G
L
V
FSST
T
N
S
L
L
A
QRDG----M
D
V
----LEAESTSSEEGPGEW
D
A
T
RRGRSGLNPSSSSS-DDAGDCCGTDKYMSPERQR------GE-P----YGKPA
D
I
W
A
V
G
V
T
L
A
E
F
A
VGEYPY
D
L
K
D
V
I
D
E
F
D
R
V
SRMDKPV
D
V
L
QFNKHRAV
P
L
G
T
V
F
A
D
F
C
R
L
ATLPTASQ---R-----P
T
A
Q
E
L
L
E
H
P
F
F
K
--
Q
W-HR-PF
N
L
K
D
Y
L
A
ARVPV
P
S
N
R
L
K
E
D
Y
--
L
A
K
Q
RERPPEGQQPAGPPG-------------------
35
HHSearch
93.03
25%
0
- C- -
-
2PHK
2
PHKG1_RABIT
A:
[4-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
N
Y
E
P
K
E
-
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
-----------
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
--------
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
---
E
K
------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
--
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
--
D
---
M
----
N
--
I
K
L
T
D
F
G
-----
F
S
C
Q
L
D
P
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
P
-
G
----
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
-----
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
---
R
-----
Y
T
A
E
E
A
L
A
H
P
F
F
Q
--
Q
Y
-------------------------------------------------------------------
26
HHSearch
91.82
25%
0
- C- -
-
4WOT
1
ROCK2_HUMAN
B:
[63-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
M
K
A
E
-
D
Y
D
V
V
K
-
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-----------------
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
------
D
--
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
---
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
--
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
----
D
K
--
H
---
G
----
H
--
L
K
L
A
D
F
G
-----
T
C
M
K
M
D
E
T
G
-------
M
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
-
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
-----
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
-----
N
G
V
E
E
I
R
Q
H
P
F
F
K
--
N
D
-
Q
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
--
F
D
D
I
E
D
--------------------------------
36
HHSearch
91.68
29%
0
- C- -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
Y
L
D
N
F
I
-
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
--
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
---
H
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
--
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
----
T
H
--
D
---
G
----
R
--
V
K
L
S
D
F
G
-----
F
C
A
Q
V
S
K
E
V
-------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
-
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
-
P
P
R
-----
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
---
R
-----
A
T
A
A
E
L
L
K
H
P
F
L
A
--
K
A
-------------------------------------------------------------------
24
HHSearch
90.69
24%
0
- C- -
-
2Y7J
1
PHKG2_HUMAN
C:
[89-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
F
Y
Q
-
K
Y
D
P
K
D
-
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
------------
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
--
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
---
E
K
------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
--
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
--
N
---
M
----
Q
--
I
R
L
S
D
F
G
-----
F
S
C
H
L
E
P
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
-----
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------
32
HHSearch
89.80
25%
0
- C- -
-
3V8S
1
ROCK1_HUMAN
D:
[66-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
-
D
Y
E
V
V
K
-
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-----------------
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
------
D
--
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
---
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
--
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
----
D
K
--
S
---
G
----
H
--
L
K
L
A
D
F
G
-----
T
C
M
K
M
N
K
E
G
-------
M
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
-
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
-----
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
-----
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
-
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
--
F
D
D
L
E
E
--------------------------------
27
HHSearch
89.79
24%
0
- C- -
-
2Y7J
1
PHKG2_HUMAN
D:
[90-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
-
K
Y
D
P
K
D
-
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
------------
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
--
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
---
E
K
------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
--
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
--
N
---
M
----
Q
--
I
R
L
S
D
F
G
-----
F
S
C
H
L
E
P
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
-----
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------
40
HHSearch
87.51
24%
0
- C- -
-
4LQS
1
CBK1_YEAST
A:
[92-453]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
R
R
T
R
L
S
L
E
-
D
F
H
T
V
K
-
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-----------------
K
K
----------------
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
------
A
--
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
---
R
W
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
--
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
----
D
I
--
R
---
G
----
H
--
I
K
L
S
D
F
G
-----
L
S
T
G
F
H
K
T
H
-------
D
S
N
Y
----------------------------------------------------------------------------------------------------------------------------------------
N
-
R
Q
Q
I
Q
T
W
R
K
--
S
R
R
-
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
Q
-
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
-----
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
-----
G
G
A
D
E
I
K
S
H
P
F
F
R
--
G
V
-
D
-----------------------------------------------------------------
44
HHSearch
85.95
27%
0
- C- -
-
3C0G
1
CSKP_HUMAN
B:
[19-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
-
V
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
---------------
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
--
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
---
K
R
A
D
----------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
V
----------
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
--
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
----
A
S
--
K
---
E
NS
A
-
P
--
V
K
L
G
G
F
G
-----
V
A
I
Q
L
G
E
S
G
-------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
-----
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
K
--
E
R
-
D
-----------------------------------------------------------------
41
HHSearch
84.15
26%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
Y
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------------------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
------
E
--
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
------------------------------------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
--
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
----
A
S
--
K
SKG
A
----
A
--
V
K
L
A
D
F
G
-----
L
A
I
E
V
Q
G
D
Q
-------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
-
P
----
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
-----
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
---
R
-----
I
T
A
S
E
A
L
K
H
P
W
I
C
--
Q
R
-------------------------------------------------------------------
39
HHSearch
80.37
24%
0
- C- -
-
2X0G
-
DAPK1_HUMAN
A:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
-
Y
Y
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--------------
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
--------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
------------------------------------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
--
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
----
L
D
--
R
---
N
VP
K
P
R
--
I
K
I
I
D
F
G
-----
L
A
H
K
I
D
F
G
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-
P
----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
-----
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--
P
K
-------------------------------------------------------------------
21
HHSearch
77.58
22%
0
- C- -
-
2X4F
4
MYLK4_HUMAN
A:
[86-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
F
Y
-
T
V
S
K
T
E
-
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
--------------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
-
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
------
K
--
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
---
D
E
------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
----------
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
--
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN--
R
D
--
A
---
K
----
Q
--
I
K
I
I
D
F
G
-----
L
A
R
R
Y
K
P
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
-
F
----
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
-----
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
---
R
-----
I
S
A
S
E
A
L
K
H
P
W
L
S
--
D
H
-
K
L
----------------------------------------------------------------
37
HHSearch
77.24
22%
0
- C- -
-
2QR8
-
A:
[19-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
T
D
G
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
------------------------
R
D
P
T
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
------
G
--
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
---
R
Q
------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
--
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
VDES
G
N
--
P
---
E
----
S
--
I
R
I
C
D
F
G
-----
F
A
K
Q
L
R
A
E
N
-------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
Q
-
G
----
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
T
P
E
E
I
L
A
R
I
G
S
G
--
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
---
R
-----
L
T
A
A
L
V
L
R
H
P
W
I
V
--
H
W
-
D
Q
----------------------------------------------------------------
52
Fugue
76.70
14%
35
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
--
G
Y
Q
--
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
KT
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
----------------------------
E
D
N
P
G
----------
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
--
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
----
D
D
--
D
---
G
----
N
--
V
R
I
S
D
L
G
-----
L
A
V
E
L
K
A
G
Q
-------
T
K
T
K
G
-
Y
A
G
T
PG
F
M
A
------
P
E
L
L
L
G
E
E
Y
D
F
S
V
D
Y
-------
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
--
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
--
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
-
P
E
K
R
L
G
----
F
R
D
----
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
-
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
------
D
T
-
E
----
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
70.79
23%
0
- C- -
-
4NIF
-
KS6A1_HUMAN
A:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
S
D
-
G
Y
V
V
K
E
-
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
------------------------
R
D
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
--------
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
---
R
Q
------------------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
--
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
----
V
D
--
E
---
S
GNPE
C
--
L
R
I
C
D
F
G
-----
F
A
K
Q
L
R
A
E
N
-------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
------
R
Q
-
G
----
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
D
T
P
E
E
I
L
T
R
I
G
S
G
--
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
---
R
-----
L
T
A
K
Q
V
L
Q
H
P
W
V
T
--
Q
K
-------------------------------------------------------------------
28
HHSearch
62.79
26%
0
- C- -
-
4PDP
-
?
B:
[191-472]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
F
K
-
D
F
S
I
I
D
E
V
V
G
Q
---
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
S
K
--------------------------
D
G
V
T
R
E
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
----------
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
---
A
H
------------------------------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
--
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
----
E
Q
--
D
---
D
----
P
V
L
V
K
I
T
A
F
G
-----
L
A
K
V
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
Y
V
A
P
E
V
I
---------N
E
----
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
-----
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
---
R
-----
S
T
A
A
K
A
L
N
H
P
W
I
K
--
M
S
-------------------------------------------------------------------
25
HHSearch
62.46
19%
0
- C- -
-
1TKI
-
TITIN_HUMAN
A:
[22-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
Y
M
I
A
E
-
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
---------------------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
------
M
--
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
---
T
S
------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
----------
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
--
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
T
RR
S
---
S
----
T
--
I
K
I
I
E
F
G
-----
Q
A
R
Q
L
K
P
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
-----
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
-----
M
T
A
S
E
A
L
Q
H
P
W
L
K
--
Q
K
-
I
-----------------------------------------------------------------
45
Fugue
61.31
10%
1
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
----------
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
--
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
----
V
D
--
Y
---
E
----
Y
--
R
E
E
V
H
W
A
-----
T
H
Q
L
R
L
G
R
G
-------
S
F
G
E
V
-
H
R
M
E
--
D
K
Q
------
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
-------
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
----
E
G
----
L
E
Y
----
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
-
A
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
------
G
R
-
S
----
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
------
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
---
R
-----
V
S
A
A
E
L
G
G
K
V
N
R
A
--
L
Q
-
Q
V
-
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------
48
Fugue
60.54
13%
33
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
----
M
I
--
A
---
E
----
D
--
L
G
R
G
E
F
G
-----
I
V
H
R
C
V
E
T
S
-------
S
K
-
K
T
-
Y
M
A
K
--
F
V
K
VKG
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
-------
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
-
L
V
M
I
F
E
F
I
S
G
-------
L
D
I
F
E
R
I
N
T
S
A
F
E
L
--
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
----
H
N
I
GHFD
I
R
P
E
N
I
I
Y
Q
T
R
R
S
--
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
-----
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
-----
M
T
A
S
E
A
L
Q
H
P
W
L
K
--
Q
K
-
I
E
-
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
LN
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
SI--------
53
Fugue
59.50
18%
22
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
--
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
-
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
----------
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
--
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
--
E
---
W
----
T
--
T
A
I
Q
R
V
T
-----
M
N
E
F
E
Y
L
K
L
-------
L
G
K
G
T
F
G
K
V
I
--
L
V
K
------
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
V
L
Q
N
S
RH
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
-
L
C
F
V
M
E
Y
A
N
G
----------------------
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
----
A
E
I
----
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
---
P
E
Y
L
A
P
E
V
L
E
------
D
N
-
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
-----
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
---
R
LGGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
GI
V
W
-
Q
H
-
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------
46
Fugue
56.75
14%
65
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
-----
D
G
V
A
E
Y
E
V
T
--
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
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