@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_09_0460: (2018-03-08 )
MASLQSRLAPITNINNNAYTTTAGAPILRKPEMTSAASAVYISRKEAAVSSSHGAPTNKMMATAAVTGSSRCEEATGRRSGSKRDHETSVTTDQNPQDAAKSLPPPPKKKKVTYALPHQNMEEGHFYVVLGEDIDVSTQRFKILSLLGEGTFGKVVESWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMEKVRQADPADRFPLMKIQRYFQNDSGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIVFQTGVALDYFHSELHLMHTDLKPENILMETSDTTVDPATNRHLPPDPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVILGLGWMYSTDMWSMGCIIYELYTGKLLYDTHDNLEHLHLMEKTLGRLPSEWAARCGTEEARLLYNSAGQLRPCTDPKHLARIARARTVRDVIRDDLLCDLIYGLLHYDRQKRLNARQMTTHPYVLKYYPEARQAPSYPDNRAMLRPPPIM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160..-.-.....170.......180.......190.....--..200.....-----..210---.......220.......230..--.--.--...240.-----......250.......260........270.......---------------280-.------------.--------...-----...----290------..--------..---...300.......310.......320.......330.......340.......350.......------360----..------.......370.......380..--...----..-------390---.----....----..400------------.-------.--..---.--.---...410-----..-----......420.---------......430.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
S
L
Q
S
RLAPITNINNN
A
Y
TTTAGAPILRKPEMTSAA
S
A
V
Y
I
SRKEAAVSSSHGAPTN
K
M
M
A
T
A
AVTGSS
R
C
E
E
ATGRRSGSKRDHETSVTTDQ
N
P
Q
D
A
A
KSLPPPPKK
K
K
V
T
Y
ALPHQNMEEG
H
F
Y
V
V
LGEDIDV
S
T
Q
R
F
K
I
L
S
L
LGEG
T
F
G
K
V
V
E
S
W
D
-
R
K
R
-
K
-
E
Y
C
A
V
K
I
V
RNVPKYTRD
A
K
I
E
I
Q
F
M
E
K
V
RQADP--ADRF
P
L
M
K
I
Q
-----
R
Y
F
QN---DSG
H
M
C
I
VMPKY
G
P
C
L
L
D
W
I
M
K--H--G--PF
N
H
R
H
L
-----
A
Q
I
V
F
Q
TG
V
A
L
D
Y
F
H
S
E
-
L
H
L
M
HTDLKPE
N
I
L
M
ETSD---------------TT--V------------D--------PAT-----NRH----LPP------DP--------
C
R
---
V
R
I
CDLGGCCDERHS
R
T
A
I
V
STRHYRSP
E
V
I
L
G
L
G
W
M
YSTDMWSM
G
C
I
I
Y
ELYT
G
K
L
L
YDTHD------
N
------
L
E
------
H
L
H
L
M
E
K
T
L
G
RL
P
S
E
W
A
A
RCG
T
--
E
E
A
----
R
L
-------
L
YN---S----AGQL----RPC--------------T-------
D
--
P
K
---
H
--
L
---
A
R
I
A
R
------
A
R
-----
T
V
R
D
V
I
R
D
D
L
---------
L
C
D
L
I
Y
G
L
L
H
Y
D
R
Q
KRL
N
A
R
QMTTH
P
Y
V
L
K
YYPEARQAPSYPDNRAMLRPPPIM
1
PsiBlast_PDB
84.09
34%
-39
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[37-377]
-------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
--
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
-
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
-
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
-------------------
F
------------
E
--------
T
L
Y
-----
N
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
--
R
K
Q
----
K
Y
-------
F
Y
K
---
G
----
G
L
V
W
D
---
E
N
S
--------------
S
-------
D
--
G
R
---
Y
--
V
K
E
N
C
K
P
L
K
------
S
Y
-----
M
L
Q
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
2
PsiBlast_PDB
83.58
34%
-41
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[37-377]
-------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
--
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
-
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
-
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
-------------------
F
------------
E
--------
T
L
Y
-----
N
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
--
R
K
Q
----
K
Y
-------
F
Y
K
---
G
----
G
L
V
W
D
---
E
N
S
--------------
S
-------
D
--
G
R
---
Y
--
V
K
E
N
C
K
P
L
K
------
S
Y
-----
M
L
Q
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
3
PsiBlast_PDB
83.20
34%
-35
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[37-377]
-------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
--
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
-
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
-
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
-------------------
F
------------
E
--------
T
L
Y
-----
N
E
H
----
K
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
--
R
K
Q
----
K
Y
-------
F
Y
K
---
G
----
G
L
V
W
D
---
E
N
S
--------------
S
-------
D
--
G
R
---
Y
--
V
K
E
N
C
K
P
L
K
------
S
Y
-----
M
L
Q
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
6
PsiBlast_PDB
82.98
37%
-29
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[10-331]
--------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
--------
P
K
I
-----
K
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
--
R
K
Y
FHHD
R
L
-------
D
W
D
EHS
S
----
A
G
R
Y
V
S
--
R
A
C
--------------
K
-------
P
--
L
K
---
E
--
F
---------------------
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
8
PsiBlast_PDB
82.68
34%
-32
- C1 -
-
2EU9
1
CLK3_HUMAN
A:
[5-345]
-------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
---
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
--
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
-
N
---
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
--
N
FQ
P
Y
P
L
P
H
V
-----
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
-
E
-
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
-------------------
F
------------
E
--------
T
L
Y
-----
N
E
H
-----
S
C
------
E
E
K
S
V
KN---
T
S
---
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
------
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
--
T
--
R
K
Q
----
K
Y
-------
F
Y
K
---
G
----
G
L
V
W
D---
E
N
S
--------------
S
-------
D
--
G
R
---
Y
--
V
K
E
N
C
K
P
L
K
------
S
Y
-----
M
L
Q
D
S
L
E
H
V
Q
---------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
------------------
5
PsiBlast_PDB
82.61
37%
-29
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[10-331]
--------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
--------
P
K
I
-----
K
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
--
R
K
Y
FHHD
R
L
-------
D
W
D
EHS
S
----
A
G
R
Y
V
S
--
R
A
C
--------------
K
-------
P
--
L
K
---
E
--
F
---------------------
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
4
PsiBlast_PDB
81.76
37%
-34
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[10-331]
--------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
-----------------
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
--
R
K
Y
FHHD
R
L
-------
D
W
D
EHS
S
----
A
G
R
Y
V
S
--
R
A
C
--------------
K
-------
P
--
L
K
---
E
--
F
---------------------
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
9
PsiBlast_PDB
81.65
36%
-28
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[10-331]
--------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
E
A
Y
------------
N
----------------
K
R
D
E
R
T
L
I
N
P
------
D
--------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
--
R
K
Y
FHHD
R
L
-------
D
W
D
E
H
S
S
----
A
G
R
Y
V
S
--
R
A
C
--------------
K
-------
P
--
L
K
---
E
--
F
---------------------
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
---------------------------
40
HHSearch
80.72
36%
-31
- C1 -
-
5J1W
5
CLK1_HUMAN
A:
[13-336]
-----------------------------------------------------------------------------------------------------------------------------------------
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
-
G
-
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
---
H
-
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
--
E
------------
A
Y
N
------
P
K
I
K----
R
D
E
----
R
T
L
------
I
N
--------
P
D
---
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
---------
R
K
-------
Y
F
H
---
H
-----
D
R
L
----
D
W
D
--------------
E
-------
H
--
S
S
---
A
--
G
---
R
Y
V
S
R
A
-----
C
K
PLKEF
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------------
42
HHSearch
79.27
36%
-25
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[13-336]
-----------------------------------------------------------------------------------------------------------------------------------------
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
-
G
-
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
--
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
---
H
-
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
--
G
FL
P
F
R
L
D
H
I
-----
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
---------------
Y
T
--
E
------------
A
Y
N--------------
R
D
E
----
R
T
L
------
I
N
--------
P
D
---
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
------
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
---------
R
K
-------
Y
F
H
---
H
-----
D
R
L
----
D
W
D
--------------
E
-------
H
--
S
S
---
A
--
G
---
R
Y
V
S
R
A
-----
C
K
PLKEF
M
L
S
Q
D
V
E
H
E
R
---------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------------
10
PsiBlast_PDB
78.14
34%
-25
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[20-356]
--------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
---
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
R
R
-
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
--
D
N
K
N
L
C
V
Q
M
F
-----
D
W
F
-
D
---
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
--
N
YL
P
Y
P
I
H
Q
V
-----
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
---------------
Y
E
--
L
------------
T
------------------------
D
E
------
R
S
--------
V
K
ST
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
------
N
------
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
--
T
--
R
K
Q
----
K
Y
-------
F
Y
R
---
G
----
R
L
D
W
----
D
E
N
--------------
T
-------
S
--
A
G
---
R
--
Y
---
V
R
-
E
N
------
C
K
-----
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
----
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------------
20
PsiBlast_PDB
75.96
26%
0
- C- -
-
3BEG
-
A:
[12--3]
------------------------------------------------------------------------------------------------------------------------------
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
--
N
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
EA---------------------------------------
A
G
N
----
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
--
K
Y
S
----
K
E
-------
F
F
T
---
K
----
K
G
D
L
----
K
H
I
--------------
T
K
L
-----
K
--
P
W
---
G
--
L
---
F
E
V
L
V
------
E
K
-----
Y
E
W
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
13
PsiBlast_PDB
72.83
28%
-42
- C1 -
-
5MYV
2
SRPK2_HUMAN
A:
[27-387]
--------------------------------------------------------------------------------------------------------------------------------------
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
Q
G
-
K
-
R
F
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
P
--
S
D
P
N
K
D
M
V
V
Q
LI
D
D
F
K
I
S
G
M
---
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
SN
Y
--
Q
--
G
L
P
V
R
C
V
-----
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
-
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
C
V
D
D
---------------
A
Y
--
V
R
R
M
A
A
E
A
T
E
W
QK------------------
L
L
----
V
N
P
LDPRNA
D
K
--------
I
R
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
GEDYS
R
D
------
E
D
------
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
--
L
S
G
--
K
Y
S
----
R
E
-------
F
F
N
---
R
----
R
G
E
L
----
R
--------------------------------
H
--
I
---
T
K
L
-
K
------
P
W
-----
S
L
F
D
V
L
V
E
K
Y
GWP
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------------------
12
PsiBlast_PDB
71.94
28%
-43
- C1 -
-
2X7G
7
SRPK2_HUMAN
A:
[27-387]
--------------------------------------------------------------------------------------------------------------------------------------
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
Q
G
-
K
-
R
F
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
P
--
S
D
P
N
K
D
M
V
V
Q
LI
D
D
F
K
I
S
G
M
---
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
--
Q
--
G
L
P
V
R
C
V
-----
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
-
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
C
V
D
D
---------------
A
Y
--
V
R
R
M
A
A
E------------------------
L
L
----
V
N
P
LDPRNA
D
K
--------
I
R
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
EDYS
R
D
------
E
D
------
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
--
L
S
G
--
K
Y
S
----
R
E
-------
F
F
N
---
R
----
R
G
E
L
----
R
--------------------------------
H
--
I
---
T
K
L
-
K
------
P
W
-----
S
L
F
D
V
L
V
E
K
Y
GWP
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------------------
18
PsiBlast_PDB
71.52
26%
-37
- C1 -
-
5MY8
24
?
A:
[9-381]
-------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
--
N
D
P
N
R
E
M
V
V
Q
LL
D
D
F
K
I
S
G
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
Q
R-----------------------------------------
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
--
K
Y
S
----
K
E
-------
F
F
T
---
K
----
K
G
D
L
----
K
H
I
--------------
T
K
L
-----
K
--
P
W
---
G
--
L
---
F
E
V
L
V
------
E
K
-----
Y
E
W
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
21
HHSearch
70.43
28%
-39
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[96-413]
-----------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
--
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
F
---
R
-
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
--
N
--
K
FQ
G
F
S
L
P
L
V
-----
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
--
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
---------------
R
-----------------------------------------------------------
S
G
---
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
------
E
------
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
----
A
----
K
N
-------
F
V
S
---
S
----
K
G
Y
P
----
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
R
S
-------
R
--
R
G
K
L
R
G
--
P
---
P
E
S
R
E
------
W
G
-----
N
A
L
K
G
C
D
D
P
L
---------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------
19
PsiBlast_PDB
70.09
26%
-45
- C1 -
-
1WAK
5
SRPK1_HUMAN
A:
[22-395]
------------------------------------------------------------------------------------------------------------------------
C
K
--
Y
H
L
V
K
I
G
---
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
--
N
D
P
N
R
E
M
V
V
Q
LL
D
D
F
K
I
S
G
V
---
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
-------
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
---------------------------------
T
-----
A
G
N
----
F
L
V
------
N
P
LEPKNAEK
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
------
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
--
L
I
V
A
G
--
K
Y
S
----
K
E
-------
F
F
T
---
K
----
K
G
D
L
----
K
H
I
--------------
T
K
L
-----
K
--
P
W
---
G
--
L
---
F
E
V
L
V
------
E
K
-----
Y
E
W
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------------
22
HHSearch
69.18
27%
-46
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[75-392]
-----------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
--
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
F
---
R
-
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
--
N
--
K
FQ
G
F
S
L
P
L
V
-----
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
--
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
---------------
R
-----------------------------------------------------------
S
G
---
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
------
E
------
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
--
A
K
N
----
F
V
SSKGYPR
Y
C
T
---
V
T
T
LS
D
G
S
V
V
L
N
G
G
R
S
--------------
R
-------
R
G
K
L
R
---
G
--
P
---
P
E
S
R
E
------
W
G
-----
N
A
L
K
G
C
D
D
P
L
---------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------
27
HHSearch
68.59
29%
-13
- C1 -
-
5MY8
24
?
A:
[22-382]
-----------------------------------------------------------------------------------------------------------------------------------------
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
-
K
-
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
ND
P
N
R
E
M
V
V
Q
L
L
-----
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
--
S
NY
Q
--
G
L
P
L
P
C
V
-----
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
---------------
Q
Y
--
I
------------
R
R
L
A
A
E
A
T
E
W
Q
R
FLVNP
L
E
P
----
K
N
A
------
E
K
--------
L
K
---
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
EEYT
R
D
E
D
------
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
G
K
Y
----
S
----
K
E
-------
F
F
T
---
K
----
K
G
D
L
----
K
H
I
--------------
T
-------
K
--
L
K
---
P
--
W
---
G
L
F
E
V
L
V
----
E
K
-----
Y
E
W
S
Q
E
E
A
A
G
---------
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
-------------------------
43
HHSearch
68.45
28%
-45
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[32-358]
-----------------------------------------------------------------------------------------------------------------------------------------
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
-
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
--
E
M
K
Y
Y
I
V
H
L
K
-----
R
H
F
M
F
---
R
-
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
--
T
--
N
FR
G
V
S
L
N
L
T
-----
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
---------------
R
-----------------------------------------------------------
S
A
---
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
------
E
------
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
AR
K
F
F
----
E
K
-------
L
P
D
---
G
----
T
W
N
L
----
K
K
T
--------------
K
DGKREYK
P
--
P
G
---
T
R
K
L
H
--
N
I
L
G
V
ETGGPG
G
R
RAGE-
S
G
H
T
V
A
D
Y
L
K
---------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
-----------------------