@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0139: (2017-12-16 )
MNIAVIGLGHVGLAYALLFASKYKVVAYDIDSVKINNLKKGILPSKNEELMKFFCENNLNITFFDTFSEIKNNIDYYIIALPTDYDEKIGSFNTYEIEQTVSKILRVKPNGKIILKSTVPIGFSNKLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVVGDETVEGRKIAELFLSISTHSTANIKNVMLVSPTEAEAIKLFSNTFLALRVAFFNELDSFAERRSLNAEVVIKGVCLDPRIGNFYNNPSFGFGGYCLPKDTKQLKKEFIEINAPVIEAIDISNTNRKQFIVKQILERKPKIVGIYKLGMKYNSDNYKESAILSIINELLIVGIKILVYEPNLNVSIDNVIFEKNFELFTKQSDLIVANRWDRGLEAYKDKVYTRGIWIRD
Atome Classification :
(20 SA)
-------.........10........20---.---.......30........40----........50.....--.--..--60-........70........80......----.----.90........100....--.-.---.110---...-....120----.....---------..130---------.----------..-------.....------140.......150.......160.-..--.-----.-------...170-.-...-.....180....----.---..190.......200.......210.......220.......230.......240.......250.......260....--..--.--270----.---.--.....280.......290...------..------..300.......310.......320.......330.......340---------...--.--.-.----.---------------.----------.350.----------------......360.-....----..370----......-----.-----------380......--.390---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------
M
N
I
A
V
I
G
L
G
H
V
G
L
A
Y
A
L
L
F
AS---K---
Y
K
V
V
A
Y
D
ID
S
V
K
I
N
N
L
KKG----ILPSK
N
E
E
L
M
K
F
F
C
E--N--NL--
N
I
-
T
F
FD
T
F
S
E
I
KNNI
D
Y
Y
I
I
A
LPTD
Y
D
E
----K----IGSF
N
T
Y
E
I
E
Q
T
V
S
K
I
L
R
--V-K---PN
G
K
---
I
I
L
-
K
STVPIG----
F
S
N
K
L
---------
K
R
L
F----------D----------TK-------
N
I
I
F
V
------
P
E
F
L
R
E
G
C
S
I
Y
D
NLYP
S
R
I
V
VG-D-ET--V-----E-------
G
R
K
I
---
A
-
E
L
F
-
L
SISTHSTAN
I
K
----
N
---
V
M
L
VSPT
E
A
E
A
I
K
L
F
SN
T
F
L
A
L
R
V
A
F
F
N
E
L
D
S
F
A
E
R
RSLN
A
E
V
V
I
K
G
V
CLDPRIGNFYNNPSFGFGGYCLPK
D
T
K
Q
L
K
K
--
E
F
--
I
--EIN----A---
P
--
V
I
E
A
I
DISNT
N
R
K
Q
F
I
V
K
Q
I
L
------ER------KP
K
I
V
G
I
Y
K
LG
M
K
YNSDNY
K
E
S
A
I
L
S
I
I
N
E
L
L
I
VG
I
K
I
L
V
YEP-----------NL
N
--
V
--
S
-I----D---------------
N
----------
V
I
FEK----------------N
F
E
L
FTKQS
D
-
L
I
V
A----
N
R
W
D
R
----
G
L
E
A
Y
K
-----D-----------K
V
Y
TR
G
I
WI--RD-----------------------
46
HHSearch
78.11
44%
-87
- C2 -
-
3PJG
3
?
A:
[37-424]
-------
M
K
I
T
I
S
G
T
G
Y
V
G
L
S
N
G
V
L
I
A
Q
---
N
---
H
E
V
V
A
L
D
I
V
Q
A
K
V
D
M
L
N
Q
K
----
I
S
P
I
V
D
K
E
I
Q
E
Y
L
A
E
--
K
--
P
L
--
N
F
-
R
A
T
T
D
K
H
D
A
Y
R
N
A
D
Y
V
I
I
A
T
P
T
D
Y
D
P
----
K
----
T
N
Y
F
N
T
S
T
V
E
A
V
I
R
D
V
T
E
--
I
-
N
---
P
N
A
V
---
M
I
I
-
K
S
T
I
P
V
G
----
F
T
R
D
I
---------
K
E
R
L
----------
G
----------
I
D
-------
N
V
I
F
S
------
P
E
F
L
R
E
G
R
A
L
Y
D
N
L
H
P
S
R
I
V
I
G
-
E
-
R
S
--
A
-----
R
-------
A
E
R
F
---
A
-
D
L
L
-
K
E
G
A
---
I
K
Q
D
I
----
P
---
T
L
F
T
D
S
T
E
A
E
A
I
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
S
Y
A
E
S
Q
G
L
N
S
K
Q
I
I
E
G
V
C
L
D
P
R
I
G
N
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
E
--
S
V
P
----
N
---
N
--
I
I
A
A
I
V
D
A
N
R
T
R
K
D
F
I
A
D
S
I
L
------
A
R
------
K
P
K
V
V
G
V
Y
R
L
I
M
K
S
G
S
D
N
F
R
A
S
S
I
Q
G
I
M
K
R
I
K
A
K
G
I
P
V
I
I
Y
E
P
-----------
V
M
Q
--
E
--
D
-
E
F---
F
---------------
N
----------
S
R
V
V
R
----------------
D
L
N
A
F
K
Q
E
A
D
-
V
I
I
S
----
N
R
M
A
E
----
E
L
A
D
V
A
-----
D
-----------
K
V
Y
T
R
D
L
F
G
--
N
D
-----------------------
1
PsiBlast_PDB
75.76
44%
-49
- C2 -
-
3PJG
3
?
A:
[37-424]
-------
M
K
I
T
I
S
G
T
G
Y
V
G
L
S
N
G
V
L
I
A
Q
---
N
---
H
E
V
V
A
L
D
I
V
Q
A
K
V
D
M
L
N
Q
K
----
I
S
P
I
V
D
K
E
I
Q
E
Y
L
A
E
--
K
--
P
L
--
N
F
-
R
A
T
T
D
K
H
D
A
Y
R
N
A
D
Y
V
I
I
A
T
P
T
D
Y
D
P
----
K
----
T
N
Y
F
N
T
S
T
V
E
A
V
I
R
D
V
T
E
--
I
-
N
---
P
N
A
V
---
M
I
I
-
K
S
T
I
P
V
G
----
F
T
R
D
I
---------
K
E
R
L
----------
G
----------
I
D
-------
N
V
I
F
S
------
P
E
F
L
R
E
G
R
A
L
Y
D
N
L
H
P
S
R
I
V
I
G
-
E
-
R
S
--
A
-----
R
-------
A
E
R
F
---
A
-
D
L
L
-------
K
E
G
A
I
K
----
Q
DI
P
T
L
F
T
D
S
T
E
A
E
A
I
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
S
Y
A
E
S
Q
G
L
N
S
K
Q
I
I
E
G
V
C
L
D
P
R
I
G
N
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
E
--
S
V
P
----
N
---
N
--
I
I
A
A
I
V
D
A
N
R
T
R
K
D
F
I
A
D
S
I
L
------
A
R
------
K
P
K
V
V
G
V
Y
R
L
I
M
K
S
G
S
D
N
F
R
A
S
S
I
Q
G
I
M
K
R
I
K
A
K
G
I
P
V
I
I
Y
E
P
-----------
V
M
Q
--
E
--
D
E
F
----
F
---------------
N
----------
S
R
V
V
R
----------------
D
L
N
A
F
K
Q
E
A
D
-
V
I
I
S
----
N
R
M
A
E
----
E
L
A
D
V
A
-----
D
-----------
K
V
Y
T
R
D
L
F
G
--
N
D
-----------------------
48
HHSearch
74.36
44%
-48
- C2 -
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
---
N
E
V
T
I
V
D
I
L
P
S
K
V
D
K
I
N
N
G
----
L
S
P
I
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
--
Q
L
--
S
I
-
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
--
V
-
N
---
S
H
A
T
---
L
I
I
-
K
S
T
I
P
I
G
----
F
I
T
E
M
---------
R
Q
K
F
----------
Q
----------
T
D
-------
R
I
I
F
S
------
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
-
C
-
E
E
--
N
-----
D
S
P
K
V
K
A
D
A
E
K
F
---
A
-
L
L
L
-
K
S
A
A
---
K
K
N
N
V
----
P
---
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
R
I
G
M
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
N
--
N
I
P
----
Q
---
T
--
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
------
N
V
L
K
E
QES
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
--
K
--
L
E
S
----
E
D--------------
Q
----------
S
V
L
V
N
----------------
D
L
E
N
F
K
K
Q
A
N
-
I
I
V
T
----
N
R
Y
D
N
----
E
L
Q
D
V
K
-----
N
-----------
K
V
Y
S
R
D
I
F
G
--
R
D
-----------------------
37
Fugue
72.55
43%
-40
* C2 *
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
---
N
E
V
T
I
V
D
I
L
P
S
K
V
D
K
I
N
N
G
----
L
S
P
I
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
--
Q
L
--
S
I
-
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
--
V
-
N
---
S
H
A
T
---
L
I
I
-
K
S
T
I
P
I
G
----
F
I
T
E
M
---------
R
Q
K
F
----------
Q
----------
T
D
-------
R
I
I
F
S
------
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
-
C
-
E
E
--
N
-----
D
-------
S
P
K
V
---
K
-
A
D
A
-
E
K
F
A
L
L
L
K
S
A
A
K
KN
N
V
P
---
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
R
I
G
M
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
N
--
N
I
P
----
Q
---
T
--
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
------
N
V
L
K
E
QES
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
KL
E
--
S
-
E
----
D
---------------
Q
----------
S
V
L
V
N
----------------
D
L
E
N
F
K
K
Q
A
N
-
I
I
V
T
----
N
R
Y
D
N
----
E
L
Q
D
V
K
-----
N
-----------
K
V
Y
S
R
D
I
F
G
--
R
D
-----------------------
2
PsiBlast_PDB
70.24
44%
-18
- C2 -
-
1DLI
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
---
N
E
V
T
I
V
D
I
L
P
S
K
V
D
K
I
N
N
G
----
L
S
P
I
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
--
Q
L
--
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
-
A
E
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
--
V
-
N
---
S
H
A
T
---
L
I
I
-
K
S
T
I
P
I
G
----
F
I
T
E
M
---------
R
Q
K
F
----------
Q
----------
T
D
-------
R
I
I
F
S
------
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
-
C
-
E
E
--
N
-----
D
-------
S
P
K
V
K
A
D
A
-
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
----
P
---
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
R
I
G
M
H
Y
N
N
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
N
--
N
I
P
----
Q
---
T
--
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
N
V
L
K
E
Q
E
S
------
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
--
K
LE
S
-
E
----
D
---------------
Q
----------
S
V
L
V
N
----------------
D
L
E
N
F
K
K
Q
A
N
-
I
I
V
T
----
N
R
Y
D
N
----
E
L
Q
D
V
K
-----
N
-----------
K
V
Y
S
R
D
I
F
G
--
R
D
-----------------------
3
PsiBlast_PDB
70.22
44%
-13
- C2 -
-
1DLJ
5
UDG_STRPY
A:
[1-402]
-------
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
L
---
Q
---
N
E
V
T
I
V
D
I
L
P
S
K
V
D
K
I
N
N
G
----
L
S
P
I
Q
D
E
Y
I
E
Y
Y
L
K
S
--
K
--
Q
L
--
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
-
A
E
L
V
I
I
A
T
P
T
N
Y
N
S
----
R
----
I
N
Y
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
--
V
-
N
---
S
H
A
T
---
L
I
I
-
K
S
T
I
P
I
G
----
F
I
T
E
M
---------
R
Q
K
F
----------
Q
----------
T
D
-------
R
I
I
F
S
------
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
-
C
-
E
E
--
N
-----
D
-------
S
P
K
V
K
A
D
A
-
E
K
F
A
L
L
L
K
S
A
A
K
K
N
N
V
----
P
---
V
L
I
M
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
R
I
G
M
H
Y
N
N
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
--
N
Y
--
N
--
N
I
P
----
Q
---
T
--
L
I
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
N
V
L
K
E
Q
E
S
------
P
V
K
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
P
-----------
M
L
N
--
K
LE
S
-
E
----
D
---------------
Q
----------
S
V
L
V
N
----------------
D
L
E
N
F
K
K
Q
A
N
-
I
I
V
T
----
N
R
Y
D
N
----
E
L
Q
D
V
K
-----
N
-----------
K
V
Y
S
R
D
I
F
G
--
R
D
-----------------------
57
HHSearch
65.48
27%
0
- C- -
-
3GG2
4
?
A:
[3-427]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
--
G
---
A
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
----
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
--
A
G
--
R
L
-
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
E
----
D
-----
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
--
A
M
S
---
R
Y
I
L
---
I
V
T
-
K
S
T
V
P
V
G
----
S
Y
R
L
I
---------
R
K
A
I
----------
Q
E
E
L
D
K
R
E
V
L
I
D
F
-------
D
I
A
S
N
------
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
-
V
-
D
S
D
-
R
-----
A
-------
R
E
L
I
---
T
-
S
L
Y
-
K
P
M
L
----
L
N
N
F
----
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
--
T
A
E
D
N
--
G
Y
R
----
M
---
E
--
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
------
T
Y
Y
K
GNV-
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
-----------
V
A
M
--
K
--
E
-
A
----
Q
K
R
LGD----------
K
----------
V
E
Y
T
T
----------------
D
M
Y
D
A
V
R
G
A
E
-
A
L
F
H
----
V
T
E
W
K
----
E
F
R
M
P
D
-----
W
S
A
L
S
Q
A
MAAS
L
V
I
D
G
R
N
V
Y
E
---------------------------
56
HHSearch
64.75
27%
0
- C- -
-
3GG2
2
?
C:
[3-426]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
--
G
---
A
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
--------
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
--
A
G
--
R
L
-
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
------
D
-----
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
--
A
M
S
---
R
Y
I
L
---
I
V
T
-
K
S
T
V
P
V
G
----
S
Y
R
L
I
---------
R
K
A
I
----------
Q
E
E
L
D
K
R
E
V
L
I
D
F
-------
D
I
A
S
N
------
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
-
V
-
D
S
D
-
R
-----
A
-------
R
E
L
I
---
T
-
S
L
Y
-
K
P
M
-------------
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
--
T
A
E
D
N
--
G
Y
R
----
M
---
E
--
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
------
T
Y
Y
KGNV-
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
-----------
V
A
M
--
K
--
E
-
A
----
Q
K
R
LGD----------
K
----------
V
E
Y
T
T
----------------
D
M
Y
D
A
V
R
G
A
E
-
A
L
F
H
----
V
T
E
W
K
----
E
F
R
M
P
D
-----
W
S
A
L
S
Q
A
MAAS
L
V
I
D
G
R
N
V
Y
E
---------------------------
49
HHSearch
58.33
27%
1
- C2 -
-
2Y0C
5
?
A:
[9-444]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
--
G
---
H
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
----
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
--
N
R
S
A
G
--
R
L
-
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
E
----
D
-----
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
--
Y
M
T
---
G
F
K
V
---
I
V
D
-
K
S
T
V
P
V
G
----
T
A
E
R
V
---------
R
A
A
V
A
E
E
L
A
K
R
GGD
Q
----------
M
F
-------
S
V
V
S
N
------
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
-
C
-
D
D
--
D
V
P
G
E
R
A
-------
R
E
L
M
---
K
-
K
L
Y
-
A
P
F
N
----
R
N
H
E
----
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
--
T
A
D
E
H
--
G
Q
S
----
L
---
Q
--
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
------
A
R
FGEDL-
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
-----------
V
A
Q
--
E
--
E
-
A
----
R
R
V
I
A
L
D
L
A
DH
P
S
W
L
E
R
----------
L
S
F
V
D
----------------
D
E
A
Q
A
A
R
D
A
D
-
A
L
V
I
----
V
T
E
W
K
----
I
F
K
S
P
D
F
V
---
A
L
G
R
L
WKTP
V
--
I
F
D
G
R
N
L
Y
E
--
P
------------------------
59
HHSearch
58.14
29%
-2
- C2 -
-
4A7P
1
?
A:
[9-426]
-------
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
--
G
---
H
E
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
----
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
--
A
G
--
R
L
-
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
----
G
----
D
G
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
--
N
L
T
---
K
P
S
V
---
I
V
T
-
K
S
T
V
P
V
G
----
T
G
D
E
V
---------
E
R
I
I
A
E
VAPN----
S
----------
G
A
-------
K
V
V
S
N
------
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
-
T
-
E
D
E
-
F
-----
A
-------
R
Q
V
M
---
R
-
E
I
Y
-
R
P
L
S
------------
P
---
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
--
T
A
A
D
N
--
E
T
P
----
L
---
R
--
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
------
K
A
M
GGDV-
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
-----------
E
G
V
--
E
--
Q
-
A
S
K
M
L
T
---------------
D
----------
V
E
F
V
E
----------------
N
P
Y
A
A
A
D
G
A
D
-
A
L
V
I
----
V
T
E
W
D
----
A
F
R
A
L
D
L
T
R
I
K
N
S
LKSP
V
-----
L
V
D
L
R
N
I
Y
P
---------------------------
7
PsiBlast_PDB
57.74
28%
-0
- C2 -
-
4A7P
1
?
A:
[9-399]
-------
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
--
G
---
H
E
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
----
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
--
N
V
K
A
G
--
R
L
-
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
R
----
G
----
D
G
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
-
K
---
P
S
-
V
---
I
V
T
-
K
S
T
V
P
V
G
----
T
G
D
E
V
---------
E
R
I
I
A
E
VAPN----
S
----------
G
A
-------
K
V
V
S
N
------
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
-
T
-
E
D
--
E
-----
F
-------
A
R
Q
V
---
M
R
E
I
Y
-
R
P
L
S
-----
P
----------
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
--
T
A
--
A
--
D
N
E
----
T
---
P
L
R
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
------
K
A
M
GGDV-
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
EGV
E
-------
Q
A
S
--
K
--
M
-
L
----
T
---------------
D
----------
V
E
F
V
E
----------------
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
----
T
E
W
D
----------------------------------------------------------------
58
HHSearch
57.48
27%
-26
- C2 -
-
3VTF
2
?
A:
[22-431]
-------
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
--
G
---
H
R
V
V
G
Y
D
V
N
P
S
I
V
E
R
L
R
A
G
----
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
R
--
A
L
S
S
G
--
R
L
-
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
----
D
-----
G
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
--
G
I
R
A
K
G
R
W
H
L
---
V
V
V
-
K
S
T
V
P
P
G
----
T
T
E
G
L
---------
V
A
R
A
----------
V
A
E
E
AGG
V
---
K
F
-------
S
V
A
S
N
------
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
-
A
G
D
E
--
R
-----
A
-------
A
S
F
L
---
L
-
D
V
Y
-
K
A
V
D
-------
A
----
P
---
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
--
F
G
E
S
L
--
G
L
E
----
M
---
A
--
I
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
------
E
R
L
GGL--
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
-----------
M
A
M
--
E
--
K
-
A
R
A
V
-
L
GD-------------
S
----------
V
T
Y
V
E
----------------
D
P
Q
A
L
L
D
Q
V
E
-
G
V
I
I
----
A
T
A
W
P
----
Q
Y
E
G
L
D
YR---
G
KV---------
V
V
D
G
R
Y
V
K
K
---------------------------
8
PsiBlast_PDB
56.22
28%
-4
- C2 -
-
3VTF
2
?
A:
[23-430]
--------
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
--
G
---
H
R
V
V
G
Y
D
V
N
P
S
I
V
E
R
L
R
A
G
RPHI
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
--
G
--
R
L
--
S
F
-
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
D
-----------
G
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
-
I
-
R
---
A
K
G
R
W
H
L
V
V
V
-
K
S
T
V
P
P
G
----
T
T
E
G
L
V
--------
A
R
A
V
A
E
--------
E
----------
A
G
-------
G
V
K
F
S
V
A
S
N
--
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
-------------
A
-------
G
D
E
R
---
A
-
A
S
F
-
L
L
D
V
Y
K
A
V
D
A
P
K
----
L
---
V
M
--
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
--
L
--
G
L
E
----
M
---
A
--
I
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
------
E
R
L
GGL--
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
MA
M
E
K
------
A
R
A
--
V
--
L
-
G
----
D
---------------
S
----------
V
T
Y
V
E
----------------
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
----
T
A
W
P
Q
Y
E
--
G
L
D
-
Y
R
-----
G
-----------
K
V
V
V
D
G
R
Y
V
--
K
------------------------
39
Fugue
55.26
22%
-3
- C2 -
-
2O3J
4
UGDH_CAEEL
A:
[3-471]
DQVFGKV
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
P
H
---
I
T
V
T
V
V
D
M
N
T
A
K
I
A
E
W
N
S
D
----
K
L
P
I
Y
E
P
G
L
D
E
I
V
F
A
--
A
R-
G
R
--
N
L
-
F
F
S
S
D
I
P
K
A
I
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
M
YGRG
K
----
G
M
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
--
Y
-
A
---
G
G
P
K
---
I
V
V
E
K
S
T
V
P
V
K
----
A
A
E
S
I
---------
G
C
I
L
----------
R
----------
E
A
QKL
K
F
--
Q
V
L
S
N
------
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
-
G
-
E
S
--
S
-----
P
-------
E
G
L
Q
---
A
-
V
A
E
-
L
V
R
I
Y
E
N
W
V
P
R
N
----
R
---
I
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
I
G
S
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
--
L
C
--
E
--
S
L
N
L
P
Q
V
A
---
D
--
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
------
A
E
L
FNTV-
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
-----------
K
V
Q
--
K
--
S
-
Q
----
M
---------------
L
----------
N
D
L
A
S
V
TS
A
Q
D
V
E
R
L
I
T
V
E
SD
P
Y
A
A
A
R
G
A
H
A
-
I
V
V
L
----
T
E
W
D
E
FVEL
N
Y
S
Q
I
H
-----
N
-----------
D
M
Q
H
P
A
A
I
F
D
G
R
L
ILD
Q
K
A
L
R
E
I
GFR
T
F
A
I
GTSPDQ
4
PsiBlast_PDB
54.89
29%
-3
- C2 -
-
2Y0E
5
?
A:
[9-369]
-------
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
--
G
---
H
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
----
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
--
N
--
R
S
A
G
R
L
-
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
E
----
D
-----
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
--
Y
-
M
---
T
G
F
K
---
V
I
V
D
K
S
T
V
P
V
G
----
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
G
----------
D
----------
Q
M
F
------
S
V
V
S
N
------
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
-
D
D
--
V
-----
P
-------
G
E
R
A
---
R
-
E
L
M
-
K
K
L
Y
A
P
F
N
R
N
H
E
----
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
--
T
A
--
D
--
E
H
G
----
Q
---
S
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
------
A
R
FGEDL-
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
54.20
22%
-3
- C2 -
-
3KHU
8
UGDH_HUMAN
B:
[6-448]
-------
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
MCP
E
---
I
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
----
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
S
C-
R
--
G
K
--
N
L
-
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
----
Y
GMGK
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
--
N
S
N
---
G
Y
K
I
---
V
T
E
-
K
S
T
V
P
V
R
----
A
A
E
S
I
---------
R
R
I
F
----------
D
ANTKPNL---
N
L
-------
Q
V
L
S
N
------
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
-
G
-
D
E
--
T
PEGQR
A
-------
V
Q
A
L
---
C
-
A
V
Y
-
E
H
W
V
----
P
-
R
E
----
K
---
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
--
L
C
EA
L
--
N
L
P
EV--
A
---
R
--
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
------
D
S
LFNTV-
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-----------
K
V
P
--
R
--
E
-
Q
----
I
VVDLSHP--------
G
VSEDDQVSRL
V
T
I
S
K
----------------
D
P
Y
E
A
C
D
G
A
H
-
A
V
V
I
----
C
T
E
W
D
----
M
F
K
E
L
D
YE---
R
IHKKMLKPAF-
I
F
D
G
R
R
V
L
D
--
G
------------------------
38
Fugue
54.10
24%
17
- C2 -
-
2Q3E
2
UGDH_HUMAN
A:
[2-467]
---MFEI
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
---
M
C
PE
I
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
----
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
S
C-
R
--
G
K
--
N
L
-
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
YGMG
K
----
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
--
N
-
S
---
N
G
Y
K
---
I
V
T
E
K
S
T
V
P
V
R
----
A
A
E
S
I
---------
R
R
I
F
----------
D
----------
A
N
TKPN
L
N
L
Q
V
L
S
N
------
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
-
E
T
--
P
-----
E
-------
G
Q
R
A
---
V
-
Q
A
L
-
C
A
V
Y
E
H
W
-
V
P
R
E
----
K
---
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
--
L
C
--
E
--
A
L
N
L
P
E
V
A
---
R
--
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
------
D
S
L
FNTV-
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
KVP
R
E
Q
I
V
V
D
L
S
H
D
--
Q
--
V
-
S
----
R
---------------
L
----------
V
T
I
S
K
----------------
D
P
Y
E
A
C
D
G
A
H
-
A
V
V
I
C
T
EW
D
M
F
K
E
L---
D
Y
E
R
I
H
-----
K
-----------
K
M
L
K
P
A
F
I
F
D
G
R
R
VLDGL
H
N
E
L
Q
T
I
GFQ
I
E
T
I
GKKV
9
PsiBlast_PDB
54.07
29%
-21
- C2 -
-
3GG2
4
?
A:
[3-363]
-------
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
--
G
---
A
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
----
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
--
N
V
K
A
G
--
R
L
-
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
E
----
D
----
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
--
M
-
S
---
R
Y
I
L
---
I
V
T
-
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
---------
Q
E
E
L
----------
D
----------
K
R
-------
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
-------
V
-----
D
-------
S
D
R
A
---
R
-
E
L
I
-
T
S
L
Y
K
P
M
L
L
N
N
F
----
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
--
T
---
A
--
E
D
N
----
G
YRM
E
--
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
------
T
Y
Y
K
GNV-
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
53.80
21%
-4
- C2 -
-
2O3J
4
UGDH_CAEEL
A:
[10-452]
-------
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
P
H
---
I
T
V
T
V
V
D
M
N
T
A
K
I
A
E
W
N
S
D
----
K
L
P
I
Y
E
P
G
L
D
E
I
V
F
A
A
-
R
--
G
R
--
N
L
-
F
F
S
S
D
I
P
K
A
I
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
M
----
Y
GRGK
G
M
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
--
Y
A
G
---
G
P
K
I
---
V
V
E
-
K
S
T
V
P
V
K
----
A
A
E
S
I
---------
G
C
I
L
----------
R
E
A
QKL-----
K
F
-------
Q
V
L
S
N
------
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
-
G
-
E
S
S
P
E
-----
G
-------
L
Q
A
V
A
E
L
V
-
R
I
Y
-
E
N
W
V
----
P
-
R
N
----
R
---
I
I
T
T
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
I
G
S
K
F
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
--
L
C
--
E
S
L
N
L
P
Q
V
--
A
---
D
--
Y
W
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
------
A
E
L
FNTV-
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
P
-----------
K
V
Q
--
K
--
S
-
Q
M
---
L
N
D
L
A
S
V
TS
A
Q
D
V
E
R
-
L
----------
I
T
V
E
S
----------------
D
P
Y
A
A
A
R
G
A
H
-
A
I
V
V
----
L
T
E
W
D
----
E
F
V
E
L
N
Y
S
---
Q
I
H
N
D
MQHP
A
A
-
I
F
D
G
R
L
I
L
D
--
Q
------------------------
5
PsiBlast_PDB
53.80
29%
-2
- C2 -
-
2Y0C
5
?
A:
[9-369]
-------
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
--
G
---
H
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
----
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
--
N
--
R
S
A
G
R
L
-
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
E
----
D
-----
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
--
Y
-
M
---
T
G
F
K
---
V
I
V
D
K
S
T
V
P
V
G
----
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
G
----------
D
----------
Q
M
F
------
S
V
V
S
N
------
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
-
D
D
--
V
-----
P
-------
G
E
R
A
---
R
-
E
L
M
-
K
K
L
Y
A
P
F
N
R
N
H
E
----
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
--
T
A
--
D
--
E
H
G
----
Q
---
S
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
------
A
R
FGEDL-
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------