@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0218: (2017-12-17 )
MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPNINRAAEKIYQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKAAKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTAVADMGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGVVKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPAVGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDEGMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKTTAVRIIPKGREGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKN
Atome Classification :
(20 SA)
----------------------------------------------.........---10.......------.20..-..--....30.---......---.40..-------......50.........60........70.....----------.---..-------80.....------...90...-.....100..--....---.110-------.........120.........130.......--140.......150...----...-----.160..----------------------------------------------------------.....170.......180....--...190.......200---------------.......210.......220.....-..230--.......240-----..------...-----------..250......--------.260........270.......280.......290.--......300.....----..310-.......320.........330.......340.......----350.......360....-----.---------..370....-...--380....--------.---..390.-.....-----.400..--.....410-.------......420.-------------------......430.......440...---------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------M
D
I
R
Q
V
T
E
T
---
I
A
M
I
EEQNF------
D
I
R
T
I
-TM--
G
I
S
L
L
D
C---IDP
N
I
N
---
R
A
A
E
K
-------
I
Y
Q
K
I
T
T
-KAA
N
L
V
AV
G
D
E
I
A
A
ELGI
P
I
VNKRVS----------V---
T
P
-------
I
S
L
IGAA------TDAT
D
Y
V
V
-
L
A
K
A
L
D
K
A
A
K
--
E
IG
V
---
D
F---------I
G
G
F
S
A
L
V
Q
K
--
G
YQKG
D
E
I
L
I
N
S
I
P
R
A
L
A
E
--
T
D
K
V
C
SSVNIGSTKSG----
I
N
M
-----
T
A
V
A
D
M
----------------------------------------------------------
G
R
I
I
K
E
TANL
S
D
M
G
V
A
K
L
V
V
F
A
--NAVEDNP
F
M
A
GAFHGV---------------GE
A
D
V
I
I
N
VGVS
G
P
G
V
V
K
R
A
L
E
K
VR-GQ
S
F
D
--
V
V
A
E
T
V
K
K
T
A
-----
F
K
------
I
T
R
-----------
I
G
Q
L
V
G
Q
M
A
S
E
--------RLG-
V
E
F
G
I
V
D
LSLAPTPAV
G
D
S
V
A
R
V
L
E
EMGLETV--GTH
G
T
T
A
A
L
A
L
L
N
D
----
Q
V
KKG-
G
V
M
A
CNQV--GGLS
G
A
F
I
PVSEDE
G
M
I
A
A
VQNGSL
N
L
E
K
----
L
E
A
M
T
A
I
C
S
VG
L
D
M
I
AI-----P---------EDT
P
A
E
T
I
A
-
A
M
I
--ADE
A
A
I
G
--------
V
---
I
N
M
K
T
T
-
A
V
R
I
I
-----PKGREG--
D
M
I
E
FGGL-L------GTA
P
V
M
K
VNG-------------------ASS
V
D
F
I
SRGGQIPA
P
I
HSFKN---------------
19
HHSearch
82.47
100%
-110
- C4 -
-
2HA9
-
Y239_STRPN
A:
[1-440]
----------------------------------------------
M
D
I
R
Q
V
T
E
T
---
I
A
M
I
E
E
Q
N
F
------
D
I
R
T
I
-
T
M
--
G
I
S
L
L
D
C
---
I
D
P
D
I
N
---
R
A
A
E
K
-------
I
Y
Q
K
I
T
T
-
K
A
A
N
L
V
A
V
G
D
E
I
A
A
E
L
G
I
P
I
V
N
K
R
V
S
----------
V
---
T
P
-------
I
S
L
I
G
A
A
------
T
D
A
T
D
Y
V
V
-
L
A
K
A
L
D
K
A
A
K
--
E
I
G
V
---
D
F
---------
I
G
G
F
S
A
L
V
Q
K
--
G
Y
Q
K
G
D
E
I
L
I
N
S
I
P
R
A
L
A
E
--
T
D
K
V
C
S
S
V
N
I
G
S
T
K
S
G
----
I
N
M
-----
T
A
V
A
D
M
----------------------------------------------------------
G
R
I
I
K
E
T
A
N
L
S
D
M
G
V
A
K
L
V
V
F
A
--
N
A
V
E
D
N
P
F
M
A
-
A
F
H
G
V
---------------
G
E
A
D
V
I
I
N
V
G
V
S
G
P
G
V
V
K
R
A
L
E
K
V
R
-
G
Q
S
F
D
--
V
V
A
E
T
V
K
K
T
A
-----
F
K
------
I
T
R
-----------
I
G
Q
L
V
G
Q
M
A
S
E
--------
R
L
G
-
V
E
F
G
I
V
D
L
S
L
A
P
T
----
D
S
V
A
R
V
L
E
E
M
G
L
E
T
V
--
G
T
H
G
T
T
A
A
L
A
L
L
N
D
----
Q
V
K
K
G
-
G
V
M
A
C
N
----------------
D
E
G
M
I
A
A
V
Q
N
G
S
L
N
L
E
K
----
L
E
A
M
T
A
I
C
S
---
D
M
I
A
I
-----
P
---------
E
D
T
P
A
E
T
I
A
-
A
M
I
--
A
D
E
A
A
I
G
--------
V
---
I
N
M
K
T
T
-
A
V
R
I
I
-----
P
K
G
K
E
G
--
D
M
I
E
F
------------
T
A
P
V
M
K
V
N
G
-------------------
A
S
S
V
D
F
I
S
R
G
G
Q
I
P
A
P
I
--------------------
1
PsiBlast_PDB
81.68
95%
-110
- C4 -
-
2HA9
-
Y239_STRPN
A:
[2-440]
-----------------------------------------------
D
I
R
Q
V
T
E
T
---
I
A
M
I
E
E
Q
N
F
------
D
I
R
T
I
-
T
M
--
G
I
S
L
L
D
C
---
I
D
P
D
I
N
---
R
A
A
E
K
-------
I
Y
Q
K
I
T
T
-
K
A
A
N
L
V
A
V
G
D
E
I
A
A
E
L
G
I
P
I
V
N
K
R
V
S
----------
V
---
T
P
-------
I
S
L
I
G
A
A
------
T
D
A
T
D
Y
V
V
-
L
A
K
A
L
D
K
A
A
K
--
E
I
G
V
---
D
F
---------
I
G
G
F
S
A
L
V
Q
K
--
G
Y
Q
K
G
D
E
I
L
I
N
S
I
P
R
A
L
A
E
--
T
D
K
V
C
S
S
V
N
I
G
S
T
K
S
G
----
I
N
M
-----
T
A
V
A
D
M
----------------------------------------------------------
G
R
I
I
K
E
T
A
N
L
S
D
M
G
V
A
K
L
V
V
F
A
--
N
A
V
E
D
N
P
F
M
A
-
A
F
H
G
V
---------------
G
E
A
D
V
I
I
N
V
G
V
S
G
P
G
V
V
K
R
A
L
E
K
V
R
-
G
Q
S
F
D
--
V
V
A
E
T
V
K
K
T
A
-----
F
K
------
I
T
R
-----------
I
G
Q
L
V
G
Q
M
A
S
E
--------
R
L
G
-
V
E
F
G
I
V
D
L
S
L
A
P
T
----
D
S
V
A
R
V
L
E
E
M
G
L
E
T
V
--
G
T
H
G
T
T
A
A
L
A
L
L
N
D
----
Q
V
K
K
G
-
G
V
M
A
C
N
----------------
D
E
G
M
I
A
A
V
Q
N
G
S
L
N
L
E
K
----
L
E
A
M
T
A
I
C
S
---
D
M
I
A
I
-----
P
---------
E
D
T
P
A
E
T
I
A
-
A
M
I
--
A
D
E
A
A
I
G
--------
V
---
I
N
M
K
T
T
-
A
V
R
I
I
-----
P
K
G
K
E
G
--
D
M
I
E
F
------------
T
A
P
V
M
K
V
N
G
-------------------
A
S
S
V
D
F
I
S
R
G
G
Q
I
P
A
P
I
--------------------
26
HHSearch
38.66
21%
-230
- C4 -
-
3NDQ
-
A:
[78-101]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
P
N
L
R
K
N
V
L
C
G
N
I
P
P
D
L
----
F
A
R
M
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
35.78
22%
-116
- C- -
-
3FRR
-
IST1_HUMAN
A:
[162-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
Y
L
I
E
I
A
K
--
N
Y
N
V
---
P
Y
---------
E
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
31.78
15%
-99
- C2 -
-
5AYN
9
?
A:
[7-426]
----------------------------------------------
L
R
I
E
T
Q
L
L
L
---
G
R
L
L
T
R
S
G
D
------
Q
A
W
D
F
-
V
V
--
P
F
A
L
L
V
I
---
F
P
G
K
-----------------------
L
-
Q
V
A
A
F
Y
Y
L
I
V
K
I
G
T
F
L
L
T
P
S
S
G
K
W
I
D
----------
T
---
H
P
----------------------
R
I
Q
V
V
K
-
W
G
V
W
L
Q
F
F
A
I
--
L
A
G
M
---
V
F
---------
F
G
M
L
D
G
L
V
R
A
--
G
G
R
--
E
S
W
L
L
S
V
L
F
I
A
L
A
L
--
S
G
V
M
A
S
---
L
G
S
Q
I
T
D
----
I
S
V
-----
G
N
--
D
L
----------------------------------------------------------
A
P
S
L
V
A
P
E
K
L
T
H
F
N
S
W
L
R
R
I
D
L
--
A
T
E
V
G
A
P
I
L
A
G
A
L
F
P
L
--------------------------
A
G
L
F
L
I
G
L
W
N
L
V
S
F
-
V
P
E
Y
F
--
L
L
R
N
V
I
Q
R
S
G
-----
L
K
------
I
K
V
-----------
L
T
E
A
I
N
L
R
G
S
F
--------
S
D
P
-
I
F
W
L
I
L
S
Y
A
L
L
W
L
S
V
L
S
P
H
G
V
L
L
A
A
Y
L
K
D
E
M
-----
R
L
P
E
T
E
I
G
L
F
R
G
----
L
G
A
V
F
-
G
L
I
S
T
V
S
F
--
P
Y
L
V
R
R
L
-------
G
L
I
S
S
S
R
------
W
H
----
L
G
F
Q
G
V
T
L
G
I
A
V
T
A
F
A
M
-----
G
---------
S
T
A
S
V
Y
V
F
L
-
G
C
I
L
L
S
R
V
G
L
Y
G
--------
F
---
S
N
G
E
F
E
L
R
Q
R
L
I
-----
P
E
G
R
R
G
--
E
L
N
S
L
S
S
L
-
T
------
T
T
S
A
T
L
I
L
F
S
-------------------
A
G
S
L
--
L
P
Q
T
E
D
F
K
Y
L
V
Y
V
S
L
A
A
V
L
L
A
N
V
V
F
I
K
W
S
SR
21
HHSearch
30.49
17%
-189
- C4 -
-
3QZ6
-
?
A:
[35-101]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
G
-
L
D
Y
F
I
V
D
C
E
H
A
A
Y
T
F
--
R
E
I
N
H
L
V
S
V
A
K
-------
N
A
G
V
S
V
L
V
-
R
I
P
Q
VD
R
A
H
V
Q
R
-------
L
L
D
--
I
G
A
E
G
F
M
I
P
G
V
Q
S
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
30.05
31%
-175
- C4 -
-
2RFK
-
TRUB_PYRFU
A:
[38-78]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
-
I
Q
F
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
--
G
H
G
G
T
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
27.39
19%
27
* C2 *
-
5A07
1
KTR4_YEAST
A:
[40-434]
---------------------------------------------D
H
D
A
E
V
L
D
S
I
---
M
D
R
L
H
E
P
L
Y
------
E
K
D
T
F
-------
D
P
N
E
V
---
L
A
E
N
K
Q
---
L
Y
E
E
F
-------
L
L
Q
E
I
S
E
P
K
V
D
N
L
V
R
S
G
D
P
L
A
---------
G
K
A
K
----------
G
---
T
I
-------
L
S
L
V
----------
R
N
S
D
L
E
D
-
I
I
S
S
I
Q
Q
L
E
E
--
E
Y
N
K
---
N
F
---------
G
Y
P
Y
T
F
L
N
D
E
--
E
F
---
T
D
E
F
K
D
G
I
K
S
I
L
P
K
---
D
R
V
V
E
F
G
T
I
G
P
D
N
------
W
N
M
-----
P
D
S
I
D
R
----------------------------------------------------------
E
R
Y
D
Q
E
M
D
K
M
S
K
E
N
I
Q
----
Y
A
--
E
-
V
E
S
Y
H
N
M
C
R
F
Y
S
K
-------------------
E
F
Y
H
H
P
L
L
S
K
Y
K
Y
V
W
R
L
E
P
N
V
----
N
F
Y
--------------------------
C
K
-----------
I
N
Y
D
V
F
Q
F
M
N
K
--------
N
-
D
-
K
I
Y
G
F
V
-
L
N
L
Y
D
S
P
Q
T
I
E
T
L
W
T
S
T
M
D
F
V
E
E
H
P
--
N
Y
L
N
V
N
G
A
F
A
W
L
K
D
----
N
S
Q
N
---
P
K
N
Y
D
Y
T
--
Q
G
Y
S
T
C
H
F
W
T
N
-----
F
E
I
V
D
L
D
F
L
R
S
E
P
----
Y
E
K
Y
M
Q
Y
L
E
E
K
G
G
F
Y
Y
E
-----
R
W--------
G
D
A
P
V
R
S
L
A
L
A
L
F
--
A
D
K
S
S
I
H
--------
W
FRD
I
G
Y
H
H
T
-
P
Y
T
N
C
-----
P
T
C
P
A
D
--
S
D
R
C
N
G
N
C
-
V
------
P
G
K
F
T
-------------------------
P
W
S
D
L
D
N
Q
N
C
Q
A
T
W
I
R
H
S
M
S
E
E
E
L
E
MY---------
13
PsiBlast_PDB
27.28
41%
-170
- C4 -
-
5CXW
-
A:
[9-56]
-------------------------------------------------
R
Q
V
T
R
E
-----
L
L
E
L
F
N
I
------
D
E
Q
T
L
N
T
Q
--
G
L
V
V
T
T
T
---
I
D
P
Q
A
Q
---
R
A
A
E
K
-------
A
V
A
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
27.03
11%
-210
* C4 *
-
1U5T
-
SNF8_YEAST
A:
[129-165]
----------------------------------------------
V
G
L
D
D
L
E
K
S
---
I
D
M
L
K
S
L
E
-------
C
F
E
I
F
-
Q
I
R-
G
K
K
F
L
R
S
---
V
P
N
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
25.15
41%
-169
- C4 -
-
5CRF
-
PBP1A_MYCTU
A:
[9-61]
-------------------------------------------------
R
Q
V
T
R
-----
E
L
L
E
L
F
N
I
------
D
E
Q
T
L
N
T
Q
--
G
L
V
V
T
T
T
---
I
D
P
Q
A
Q
---
R
A
A
E
K
-------
A
V
A
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
24.76
18%
-116
- C4 -
-
2KPO
-
?
A:
[15-87]
---------------------------------------------------
I
E
E
A
---
R
K
M
A
E
K
A
N
L
------
E
L
R
T
V
-
K
T
--
E
D
E
L
K
K
Y
---
L
-
E
E
F
R
---
K
E
S
Q
N
-------
I
K
V
L
I
L
V
-
S
N
D
E
E
L
D
K
A
K
E
L
A
Q
K
M
E
I
D
V
R
T
R
K
V
T
----------
S
---
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
23.76
14%
6
- C5 -
-
5L3T
-
THP1_YEAST
B:
[1-455]
--------------------------MD
M
A
N
Q
L
L
D
E
L
A
H
GNFSHLT
L
N
L
S
Q
N
G
R
E
---
I
A
I
L
Q
K
Q
L
T
------
G
F
D
D
K
-
Q
L
--
E
T
F
V
E
Q
H
---
P
A
M
P
N
D
---
T
R
F
K
I
-------
M
C
T
S
F
L
N
-
Y
A
R
D
V
D
P
W
S
A
W
S
S
S
D
L
I
F
E
F
Y
Q
C
L
I
N
----------
C
---
L
I
NDNAPH
I
E
M
L
I
P
V
A
------
T
R
E
T
E
F
I
I
N
L
A
G
K
L
D
S
F
H
L
--
Q
L
H
T
RSH
Q
F
---------
L
S
H
I
S
S
I
L
S
R
--
L
F
N
S
I
K
P
------
P
R
G
N
A
S
--
S
T
N
I
-------
P
G
K
Q
R
----
I
L
L
-----
Y
L
V
N
K
L
----------------------------------------------------------
N
N
I
Y
F
R
I
E
--
S
P
Q
L
C
S
N
I
F
K
N
F
--
Q
P
K
S
----
M
L
A
H
F
N
E
Y
---------------
Q
L
D
Q
Q
I
E
Y
R
Y
L
L
G
R
Y
Y
L
L
N
S
Q
V
H
N
A
-
F
V
Q
F
N
--
E
A
F
Q
S
L
L
N
L
P
-----
L
T
------
N
Q
A
-----------
I
T
R
N
G
T
R
I
L
N
Y
--------
M
I
P
-
T
G
L
I
L
-----------
G
K
M
V
K
W
G
----
P
L
R
P
F
--
L
S
Q
E
T
I
D
N
W
S
V
L
Y
K
----
H
V
R
Y
G
-
N
-----------
I
Q
G
V
S
L
W
L
R
Q
N
E
R
H
L
C
A
R
Q
L
L
I
V
L
L
E
K
----
L
P
M
V
T
Y
R
N
L
I
K
T
V
I
K
S
W
TTEWG
Q
---------
N
K
L
P
Y
S
L
I
E
-
R
V
L
--
Q
L
S
I
G
P
T
--------
F
---
E
D
P
G
A
Q
-
E
I
T
I
Y
NGIHS
P
K
N
V
E
N
--
V
L
V
T
L
I
N
L
G
L
------
L
R
A
N
C
F
P
Q
L
Q
-------------------
L
C
V
V
K
K
T
T
M
I
Q
E
I
V
P
P
V
N
E
R
I
T
K
M
F
PAHSHVLW----
36
Fugue
21.76
7%
-64
* C5 *
-
3T5V
-
SAC3_YEAST
A:
[253-551]
-------------------------------------------------
S
D
V
R
P
P
---
H
I
L
V
K
T
L
D
Y
------
I
V
D
N
L
----------------
L
T
T
L
P
---
E
S
E
G
F
-------
L
W
D
R
M
R
S
-
I
R
Q
D
F
T
Y
Q
N
Y
S
G
P
E
A
V
D
C
N
E
R
I
V
R
I
H
----------
L
---
L
I
-------
L
H
I
M
V
K
S
------
N
V
E
F
S
-----
L
Q
Q
E
L
E
Q
L
H
--
K
S
L
I
---
T
L
---------
S
E
I
Y
D
D
V
R
S
S
--
G
G
T
C
P
N
E
A
E
F
R
A
Y
A
L
L
S
K
I
--
R
D
P
-------------------------
Q
Y
D
E
N
I
----------------------------------------------------------
Q
R
L
P
K
H
I
F
Q
--
D
K
L
V
Q
M
A
L
C
F
R
--
R
V
I
S
N
S
A
Y
T
E
R
G
F
V
K
T
---------------
E
N
C
----------
L
N
F
Y
A
R
F
F
Q
L
M
Q
-
S
P
S
L
P
--
L
L
M
G
F
F
L
Q
M
H
-----
L
T
------
D
I
R
-----------
F
Y
A
L
R
A
L
S
H
T
L
--------
N
K
K
H
K
P
I
P
F
I
Y
L
E
N
M
L
L
F
N
N
R
Q
E
I
I
E
F
C
N
Y
Y
S
I
E
I
I
--
N
G
D
A
A
D
L
K
T
L
Q
H
Y
S
----
H
K
L
S
-------------------------------------------------------------------
E
---------
T
Q
P
L
K
K
T
Y
L
-
T
C
L
--
E
R
R
L
Q
-----------------
K
T
T
-
Y
K
G
L
I
-----
N
G
G
E
D
N
------------------------------------------------------------------------------------
22
HHSearch
21.27
9%
-156
- C4 -
-
3CUQ
-
VPS36_HUMAN
B:
[282-327]
----------------------------------------------
L
S
P
E
D
L
V
N
A
---
C
K
M
L
E
A
L
K
L
------
P
L
R
L
R
-
V
F
DS
G
V
M
V
I
E
L
---
Q
S
H
K
E
E
---
E
M
V
A
S
-------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
21.11
14%
11
- C3 -
-
3AU7
1
TIAS_ARCFU
A:
[20-402]
----------------------------------------------
H
M
R
V
W
V
G
I
D
T
Y
L
A
V
L
A
M
E
R
V
E
------
R
E
L
G
K
-
V
I
--
G
F
P
R
L
I
R
---
L
N
P
T
I
N
---
G
A
V
S
F
-------
L
V
E
V
--
D
-
D
V
G
E
L
V
D
V
V
N
E
V
I
I
E
P
G
A
V
F
V
D
E
E
L
A
----------
V
-------------
K
L
K
P
F
A
------
D
K
A
I
K
D
V
L
-
Q
I
D
E
A
L
F
V
I
G
--
K
Y
F
I
---
P
H
L
R
H
KKG
R
G
L
I
G
A
L
A
A
V
G
A
E
--
L
E
D
F
T
L
E
L
I
A
Y
R
Y
P
E
R
F
--------------
G
T
E
R
E
Y
----
D
E
E
-----
S
F
F
D
M
D
----------------------------------------------------------
Y
E
L
Y
P
Q
T
F
D
N
V
D
W
C
N
D
V
V
V
C
I
P
--
N
------------------------------
T
P
C
P
V
L
Y
G
I
R
G
E
S
V
E
A
L
Y
K
A
M
E
S
V
K
-
T
E
P
V
D
R
R
M
I
F
V
T
N
H
A
T
D
-----
M
H
------
L
I
G
-----------
E
E
E
V
H
R
L
E
N
Y
R
--------
S
Y
R
-
L
R
G
R
V
T
L
E
P
Y
D
I
E
G
--
G
H
V
F
F
E
I
D
T
K
F
G
S
V
K
C
--
A
A
F
E
P
T
K
Q
F
R
N
V
I
R
----
L
L
R
K
G
-
D
V
V
E
V
Y
---------------------
G
S
M
K
K
D
T
I
N
L
E
K
----
I
Q
I
V
E
---------------------------------------------------------------
L
A
E
G
-
S
E
R
E
L
-----
Q
P
G
------------
F
-
Y
------
E
V
P
P
S
A
R
R
H
L
-------------------
S
K
P
L
I
R
M
N
V
E
G
R
H
I
F
R
---------------------
34
Fugue
20.18
20%
32
* C3 *
-
4M1K
1
?
A:
[6-688]
EYDLKR
L
R
N
I
G
I
A
A
H
IDAG
K
T
T
T
T
E
R
I
L
Y
Y
T
G
RIAA
V
T
T
C
F
W
KD
H
R
I
N
I
I
D
T
P
G
H
---
V
D
F
T
I
E
V
E
R
------
S
M
R
V
L
-
D
G
--
A
I
V
V
F
D
S
SQG
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
-
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
REDTFS
G
I
I
---
D
V
-------
L
R
M
K
A
Y
T
Y
GNDLG
T
D
I
R
E
I
P
I
-
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
---
E
V
---------
A
A
D
F
D
E
N
I
M
L
--
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
KG
V
Q
L
L
L
-----
D
A
V
V
D
Y
LPSPLD
I
P
P
I
K
G
T
T
PEG
E
V
V
E
I
H
PDPNG
P
L
A
A
L
AFKIMADPYV
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
AN
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
GLKETITG
D
T
L
V
GE
D
A
P
R
V
I
L
E
S
I
E
V
P
E
P
V
I
D
V
A
I
E
P
K
T
-
K
A
D
Q
E
--
K
L
S
Q
A
L
A
R
L
A
E
E
D
PT
F
R
------
V
S
T
HPET
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
--------
R
L
K
-
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
V
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
----
P
L
P
R
G
S
G
F
E
F
V
N
A
I
VG
G
V
I
P
K
E
Y
I
P
A
V
Q
-
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
----
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
-----
S
---------
S
E
M
A
F
K
I
A
G
-
S
M
A
--
I
K
E
A
V
Q
K
GD
P
V
I
L
E
P
I
---
M
R
V
E
V
T
-
T
P
E
E
Y
-----
M
G
D
V
I
G
--
D
L
N
A
R
R
G
Q
-
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
LAEMFG
Y
A
T
D
L
R
S
K
T
Q
GR
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
---------------
30
Fugue
19.80
14%
1
- C5 -
-
4R8A
3
FAN1_PSEAE
A:
[16-553]
LPEPF
Y
Y
L
H
N
F
R
A
V
L
A
W
I
G
E
RYADLLD
D
Q
E
R
A
F
I
A
A
F
A
E
LP
E
A
S
Q
A
L
L
V
R
M
V
M
R
K
---
G
T
L
F
R
E
G
K
L
AYAEIG
D
T
R
A
A
-
V
Q
--
P
L
L
A
L
G
W
---
V
D
A
Q
P
T
---
L
E
L
A
Q
-------
L
F
G
L
L
K
K
-
D
E
L
S
Q
L
F
R
D
H
L
G
R
A
N
L
R
K
D
A
L
L
E
R
L
Q
----------
P
LFP
E
A
-------
R
R
L
A
E
W
Q
------
A
D
F
A
E
P
V
Y
-
E
L
R
C
M
A
L
C
D
R
--
L
R
L
M
Y
FG
N
L
---------
W
Q
D
W
S
E
F
V
L
A
D
L
G
I
Y
R
Y
E
S
V
E
F
S
A
D
S
R
G
F
R
L
--
R
A
D
V
D
A
Y
L
H
L
F
D
C
R
Q
R
----
F
D
L
GEP
L
E
E
L
L
A
G
L
----------------------------------------------------------
P
G
E
P
Y
A
N
P
W
L
E
G
R
R
V
K
L
L
F
Q
F
A
--
Q
H
C
E
K
Q
-------
R
D
F
---------------
D
L
A
Q
R
L
Y
R
Q
S
-
S
H
P
G
A
R
L
R
A
I
R
S
L
E
R
G
E
R
F
A
--
E
A
H
A
L
A
R
E
A
S
-----
C
A
PES
D
A
E
R
Q
G
-----------
L
A
R
L
L
P
R
L
Q
G
K
L
G
L
P
R
Q
AR
A
A
A
-
P
E
I
D
R
L
D
L
C
L
A
F
P
S
E
P
C
S
V
E
W
A
V
R
E
H
L
E
E
P
G
C
--
A
V
H
Y
V
E
N
G
L
I
N
S
L
F
----
G
L
L
C
W
-
E
A
I
F
A
A
I
P
--
G
A
F
F
H
P
F
H
S
A
P
A
D
L
H
S
A
D
F
R
Q
R
R
A
A
L
F
E
A
C
L
G
R
L
E
D
G
S
Y
R
D
A
I
R
C
R
Y
R
D
K
-----
F
GLQSPFVYW
E
L
L
G
E
E
L
L
E
-
Q
A
L
--
D
C
L
P
A
A
H
--------
L
---
R
A
W
F
E
R
-
L
L
E
D
I
-----
P
G
N
R
A
G
LP
D
L
I
Q
F
W
P
A
-
Q
------
R
R
Y
R
M
V
E
V
K
G
PGDRLQ-------------
D
N
Q
L
R
W
L
Q
F
C
R
E
R
E
M
P
V
A
V
C
Y
V
---------------
20
HHSearch
19.03
11%
-97
- C4 -
-
3CUQ
-
SNF8_HUMAN
A:
[139-183]
----------------------------------------------
V
S
Q
D
D
L
I
R
A
---
I
K
K
L
K
A
L
G
T
------
G
F
G
I
I
-
P
V
G-
G
T
Y
L
I
Q
S
---
V
P
A
E
L
N
---
M
D
H
T
V
-------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
18.94
46%
-96
- C4 -
-
1GKY
-
KGUA_YEAST
A:
[143-182]
----------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
R
L
S
----------
A
---
A
Q
-------
A
E
L
A
Y
A
E
------
T
G
A
H
D
K
V
I
-
V
N
D
D
L
D
K
A
Y
K
--
E
L
K
----
D
F
---------
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------