@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0616: (2017-12-25 )
MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEGLSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKRYLAIVGSTAIISSFLVFFLPYLLLLGINLLVTPYQEIYIGDYSGALKELFDSNQLLYSLVTTLWYGVWGAVFSIFGLASALLVKKKLGAIFIPVAYMMVGGILWAILGLSYLEPVTTLALGYQKDISLSLVSAHLAFILFVSCLVVYGTFFLHSEDYV
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.-......-.20-........30........40..---......50....-------------....60....----....70---------.--------.....-...80........-90.-.---..-.----....-100....-----------...110.......120..-.-.....130--------........140.....--..150...-.------...---160....---....-170.......-----180.......190....-..-.200.-----------..-....210.----..-.-...220.......230--------....---....240.-------------.-----...-..250..----------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ME
F
F
I
C
N
L
V
R
V
V-QSP
R
F
Y
-
M
S
L
-
F
L
T
L
L
C
M
S
LG
N
F
L
AFN
G
I
Y
K
IE---
G
L
S
I
F
F
A
ASSIR-------------GF
S
P
I
S
L
V
A
A
----
L
I
CTL----------P--------Y
S
S
Q
I
-
I
E
D
A
E
S
H
F
L
T
A
Q
L
-
C
-
R
-I---SK-
K
----
R
Y
L
A
-
I
VG
S
T
A
I
-----------
I
S
S
F
L
V
F
F
L
P
Y
L
L
L
-LG
I
-
N
-
L
LVT
P
Y
Q
---------
E
I
Y
IGDY
S
G
A
L
K
E
L
FD--S
N
Q
L
L
Y
S
L
-
V
------
T
T
L
---
W
-
Y
G
V
W
G
---
A
V
F
S
-
I
F
G
L
A
S
A
L
L
V
-----
K
K
KLG
A
I
F
I
P
V
A
Y
M
M
V
G
-
G
I
-
L
W
A
I
L
-----------
G
L
-
S
Y
L
E
P
V
T
T
----
L
A
-L-GYQKD
I
S
L
S
L
V
S
A
H
L
---------
A
F
I
L
---
F
V
S
C
L
V
V
Y
-------------
G
-----
T
F
F
-LHSEDYV----------------------------------------------------------------------------------------------------------------------------
22
Fugue
58.38
18%
-44
- C5 -
-
4UZY
-
?
A:
[9-650]
QQPA
R
P
I
A
EGQ
Y
T
Q
T
I
Y
T
L
I
K
E
QK
F
A
E
A
I
Q
H
L
Q
Y
Q
L
Q
N
V
P
ES
R
A
A
L
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L
L
G
Y
C
Y
Y
Y
T
GQ
Y
D
M
A
S
Q
M
Y
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Q
L
V
T
L
Y
P
SN
E
D
Y
K
L
Y
Y
A
Q
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G
GM
Y
P
E
A
S
K
A
V
V
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VEGH
Q
K
A
V
T
T
L
L
V
A
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S
Y
E
Q
DD
L
T
G
C
R
R
Q
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D
K
CAPED
P
D
T
M
V
N
T
G
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I
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F
K
E
GK
F
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A
A
R
Q
K
F
N
DYQ
P
E
L
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Y
N
I
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L
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Y
Y
K
TKQ
F
G
P
A
L
K
H
L
A
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I
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R
E
HPELSVGSDGMEVRSVGNS
Q
T
L
K
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A
L
I
E
A
F
N
L
K
A
A
I
E
Y
T
M
KN
V
E
A
A
K
E
A
L
T
D
MPPRAEEELD
P
V
T
L
H
N
S
A
L
I
N
M
DSD
P
T
G
G
F
K
K
L
N
F
L
L
-
Q
S
P
P
F
P
-
P
E
T
-
F
A
N
L
L
L
L
Y
C
K
P
S
---
H
G
F
Y
D
L
A
---
A
D
V
L
A
E
N
P
Q
Y
A
G
-------------
K
L
L
S
P
D
L
Y
D
Y
----
L
Q
A
A
I
----------
G
--------
R
Y
K
S
--
P
E
E
A
F
R
R
F
D
E
L
A
T
-
R
-
H
-
V
---
E
Q
-
L
----
R
R
L
T
-
K
Q
I
Q
D
A
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-----------
I
A
R
--------------------
D
N
D
A
I
---------
K
R
A
I
N
E
Y
D
E
A
L
E
A
Y
I
P
--
G
---
L
M
A
M
-
A
------
S
I
Y
---
W
D
M
E
L
Y
S
---
N
V
E
K
-
I
F
R
Q
S
A
E
F
C
S
-----
E
H
E
V
W
K
L
N
V
A
H
T
F
F
M
Q
D
-
N
---
H
Y
K
E
-----------
A
I
-
R
Y
Y
E
P
V
V
K
----
K
-------
N
A
D
N
L
L
G
V
T
A
I
V
---------
L
A
N
L
---
C
V
S
Y
I
M
T
--------------------
S
Q
N
-
E
E
A
E
E
L
M
R
K
V
E
K
E
E
E
R
S
S
M
Q
DPDKPCF
H
L
C
I
I
N
L
V
I
G
T
L
Y
C
A
K
GN
Y
E
F
G
V
S
R
I
I
K
S
L
EE
T
D
T
W
Y
Y
A
K
R
C
F
L
A
L
I
E
N
L
A
K
H
MIVLK
D
S
S
F
T
E
I
M
A
F
L
N
E
A
E
K
H
G
K
D
I
R
V
V
F
NQSRT
I
A
S
E
A
R
M
L
K
K
M
F
L
K
L
R
30
Fugue
58.19
14%
-88
- C6 -
-
5F2T
1
ACYLT_MYCS2
A:
[44-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GG
P
E
Q
L
R
R
N
L
A
R
V
V
G
K
P
P
A
D
V
-
P
D
D
-
L
I
R
A
S
L
A
S
Y
A
R
Y
W
R
E
A
F
R
L
P
A
M
---
D
H
G
R
L
G
E
Q
L
D
V
I
-------------
D
I
D
H
L
W
S
A
L
D
A
GR
G
A
V
L
A
L
----------
P
--------
H
S
G
---------
N
W
D
M
A
G
V
-
W
-
L
-
V
---
Q
N
-
Y
----
G
P
F
T
-
T
V
A
E
R
L
K
-----------
P
E
S
L
Y
R
R
F
V
E
Y
R
E
S
-
L
G
F
-
E
-
V
L
P
L
T
G
G
---------
E
---
R
P
P
F
E
V
L
A
E
R
L
T
--
D
N
R
P
I
C
L
M
-
A
ERDLTR
S
G
V
---
Q
-
V
D
F
F
G
---
E
A
T
R
-
M
P
A
G
P
A
K
L
A
I
-----
E
T
--
G
A
A
L
F
P
V
H
C
W
F
E
G
-
D
-----
G
W
-----------
G
M
-
R
V
Y
P
E
L
D
T
------------
S
S
G
D
V
T
A
I
T
Q
A
L
---------
A
D
R
F
---
A
A
N
I
A
T
Y
P
-------------
A
-----
D
W
H
-
M
L
Q
P
Q
W
I
ADL-------------------------------------------------------------------------------------------------------------------------
29
Fugue
57.47
15%
-
- C2 -
-
2WZP
-
DIT_BPLP2
P:
[1-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GV
R
Q
Y
K
I
H
T
N
L
D
G
T
-
D
D
K
V
W
D
-
V
T
N
G
K
V
R
F
Y
Q
P
S
N
L
G
L
Q
S
T
N
N
I
W
Q
S
N
---
G
I
G
V
M
G
T
R
S
I
T
Q
-------------
P
Q
I
E
F
K
L
E
T
F
----
G
E
-
S
L
----------
E
--------
E
N
Y
Q
L
-
M
K
D
F
V
N
D
I
L
S
K
K
F
-
V
-
T
-
L
---
E
Y
-
Q
TEIF
Q
V
Y
A
-
D
L
A
L
A
D
V
TKTEGYGKNGT
F
S
E
K
I
T
F
D
I
I
T
K
W
Y
-
T
Y
E
-
N
-
L
T
F
D
K
I
Q
NGKVIAGMS
K
I
Y
G
G
T
A
P
G
N
Y
K
Y
I
K
G
--
T
S
Y
T
Y
Y
G
E
-
S
------
D
I
D
---
R
-
L
S
R
W
D
IKE
E
I
F
S
-
F
M
G
I
L
Y
P
K
L
P
-----
K
T
P
A
G
V
R
F
L
D
D
I
G
N
E
Y
T
-
A
I
-
V
F
K
T
E
-----------
Q
V
Q
D
Y
I
L
I
N
T
D
VNDE
T
Y
-
Q
-
G
W
K
G
T
T
A
L
N
L
F
P
V
-
M
---------
D
F
E
R
---
Y
R
T
R
I
I
E
K
-------------
G
-----
Q
M
E
-
L
I
N
L
S
K
A
EFKIKRKADFV-----------------------------------------------------------------------------------------------------------------
31
Fugue
57.17
17%
-51
- C6 -
-
4PHR
1
?
A:
[1-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
E
F
E
L
M
K
R
L
S
E
I
K
V
L
P
I
L
-
E
S
L
K
Y
I
-
K
H
N
-
H
A
S
V
V
R
F
G
D
G
E
I
D
L
M
T
G
H
S
I
P
Y
---
Q
D
Y
N
E
K
L
A
K
R
L
Q
-------------
Q
I
L
Q
T
K
S
D
E
K
----
L
L
V
C
L
----------
P
DVFSNMDR
Y
N
Q
N
A
-
R
H
F
W
E
R
H
F
L
K
------------
Y
S
-
E
----
F
Y
L
N
-
C
C
D
A
P
F
Y
-----------
G
S
T
F
I
S
--
R
P
Y
I
D
L
-
I
D
K
-
S
-
P
------------------
S
E
A
Y
F
E
S
L
K
E
L
W
R
--
G
K
D
L
L
I
V
E
-
G
------
A
T
S
---
R
-
S
G
V
G
N
---
D
L
F
V
-
A
A
S
S
I
K
R
L
V
C
PSKNA
F
Q
Y
Y
D
E
I
L
R
L
T
E
K
N
A
K
N
-
R
L
-
I
L
V
M
L
-----------
G
P
-
T
A
K
V
L
V
A
D
----
L
T
-
T
-
K
G
Y
Q
A
I
D
L
G
H
I
D
S
E
Y
---------
E
W
Y
E
---
M
G
A
T
Y
K
V
K
LTNKHTAEFNYDE
G
-----
I
E
L
-
E
F
S
Q
E
Y
Q
E
Q
IVARIG--------------------------------------------------------------------------------------------------------------------
27
Fugue
57.02
21%
-
- C4 -
-
4L0K
-
?
A:
[1-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
L
--
C
H
--
K
T
V
-
K
S
R
T
A
Y
-
S
K
H
-
F
P
H
K
C
Q
L
P
L
G
H
-----------------------
S
G
K
-------------
C
L
E
F
P
F
L
V
S
L
----
S
K
T
H
P
----------
R
--------
I
A
A
K
I
-
V
R
D
A
T
M
----------------
T
M
-
P
----
R
Y
V
A
-
I
L
D
D
D
I
L
-----------
L
E
K
F
------------
N
L
-
D
-
M
Q
S
L
P
------------------
E
I
T
R
L
K
I
R
E
--
K
A
A
D
Y
D
S
C
-
I
------
D
V
A
---
R
-
K
L
T
W
L
---
A
-----
Y
Q
L
H
G
A
P
I
P
-----
D
S
F
T
K
N
Y
L
E
E
F
F
G
P
M
V
A
-
G
---------------------
S
T
N
C
E
I
C
K
----
L
P
-
L
-
T
I
D
L
F
S
E
A
A
V
E
T
A
H
K
TPRLHNAEN
V
G
F
A
---
H
R
F
C
N
V
A
Q
-------------
G
NKS
L
D
E
F
Y
-
L
W
M
E
E
V
L
T
R
V
K
M
L----------------------------------------------------------------------------------------------------------------------
28
Fugue
55.33
18%
-26
- C1 -
-
5L2D
-
?
A:
[19-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
W
V
D
F
S
D
-
T
A
S
M
K
N
L
D
P
Q
G
G
F
K
V
G
T
V
F
K
K
E
ISP
G
Y
V
V
T
L
T
V
T
E
L
K
-------------
P
F
N
S
T
E
I
Y
K
K
----
R
V
E
G
T
----------
P
--------
T
A
N
T
Y
-
D
P
N
A
I
N
S
Y
L
K
G
Y
----
K
-
D
---
Y
G
-
K
----
T
P
P
S
-
V
T
G
R
T
Q
I
-----------
I
------
L
P
D
D
A
V
N
-
W
G
I
-
K
-
F
K
V
E
A
T
Y
---------
R
G
N
P
V
K
P
S
V
V
M
A
D
G
E
D
--
A
N
P
A
E
Y
G
I
-
F
------
T
T
N
GEG
W
-
E
Y
V
G
E
---
W
M
K
G
-
P
Y
T
V
M
T
E
D
M
V
-----
K
A
F
D
K
T
R
K
D
G
L
L
I
L
K
D
K
-
S
V
-
D
W
S
K
----------------
Y
L
S
P
D
T
V
----
T
G
G
L
-
G
S
Q
----------------------------------
V
F
-------------
G
-----
P
I
I
-
S
A
S
--------------------------------------------------------------------------------------------------------------------------------
23
Fugue
53.86
16%
-62
- C5 -
-
3G3L
9
?
A:
[10-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PA
E
A
K
Y
Y
I
A
G
T
I
T
D
A
-
T
T
G
Q
E
L
-
T
T
A
-
K
V
T
L
G
D
K
S
V
T
S
S
F
N
E
Q
V
N
Y
K
A
E
---
G
Y
A
L
V
V
S
A
D
G
Y
Y
P
V
K
R
Q
V
Y
L
NQVSD
G
Q
T
S
V
A
T
V
N
V
----
A
L
V
S
V
E
A
A
V
I
P
P
VVP
P
--------
T
D
P
E
T
D
I
N
E
G
E
A
T
K
V
A
D
K
A
-
V
-
E
-
V
A
KP
S
E
-
S
----
T
V
T
D
M
L
A
G
T
T
A
-------------
T
P
E
E
K
K
A
L
D
E
T
L
E
M
A
G
G
M
K
-
V
G
E
T
T
P
E
---------
V
L
A
D
G
S
I
L
A
I
T
P
V
K
F
T
--
N
P
I
Q
D
A
P
A
M
V
------
P
Y
F
---
Y
-
N
E
G
C
E
---
L
T
G
D
-
V
K
E
V
A
A
P
V
A
V
-----
A
A
D
I
Q
K
A
F
L
S
N
A
A
K
A
L
N
M
N
A
G
F
V
Q
K
I
-----------
G
Y
-
T
R
I
S
V
L
N
G
----
Y
S
-
I
L
G
Y
T
--
I
K
G
Q
L
V
S
K
K
L
---------
T
F
L
I
SG
K
Y
Y
E
G
I
V
S
Y
-------------
Q
-----
K
S
V
M
I
Y
P
N
Y
Y
S
----------------------------------------------------------------------------------------------------------------------------
26
Fugue
43.81
15%
-137
* C6 *
-
1T0I
2
LOT6_YEAST
A:
[1-185]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
G
I
I
M
-
G
S
V
R
---
A
K
R
-
V
C
P
E
I
A
A
Y
V
K
R
T
I
E
N
S
E
E
L
I
D
Q
---
K
L
K
I
Q
V
V
D
L
Q
Q
I
-------------
A
L
P
L
Y
E
D
D
D
E
----
L
I
P
A
Q
----------
I
--------
K
S
V
D
E
-
Y
A
D
S
K
T
R
S
W
S
R
I
V
-
N
-
A
-------------------------------------
L
D
I
I
V
F
V
T
P
----------------------------
Q
Y
N
W
G
Y
P
A
A
L
K
N
A
I
D
R
L
Y
H
E
W
H
G
K
P
-
A
------
L
V
V
---
S
-
Y
G
G
H
G
---
G
S
K
C
-
N
D
Q
L
Q
E
V
L
H
G
--------
L
K
M
N
V
I
G
G
V
A
V
K
I
P
-
V
------------------
G
T
-
I
P
L
P
E
D
I
V
----
P
Q
-
L
-
S
V
H
N
E
E
I
L
Q
L
L
A
S
C
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
39.46
10%
-177
- C5 -
-
5NJG
-
?
B:
[388-587]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
S
K
R
S
F
K
N
L
L
-
G
N
P
Q
A
S
-
I
A
Q
-
I
I
V
T
V
V
L
G
L
V
I
G
A
I
Y
F
G
L
K
--
N
---
D
S
T
G
I
Q
N
R
------------------
A
G
V
L
F
F
L
T
T
----
N
Q
C
F
S
----------
S
--------
V
S
A
V
E
-
L
F
V
V
E
K
K
L
F
I
H
E
Y
-
I
-
S
G
Y
---
Y
R
V
S
----
S
Y
F
L
-
G
K
L
L
S
D
L
L----------
P
M
R
M
L
P
S
I
I
F
T
C
I
V
-
Y
F
M
-
L
-
G
L
--
K
P
------------------------------
K
A
D
A
F
F
-
V
------
M
M
F
---
T
-
L
M
M
V
A
---
Y
S
A
S
-
S
M
A
L
A
I
A
A
G
Q
-----
S
V
V
S
V
A
T
L
L
M
T
I
C
F
V
F
M
-
M
I
-
F
S
G
L
L
VNLTTIASWLS
W
L
-
Q
Y
F
S
I
P
R
Y
----
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
38.92
10%
-177
- C5 -
-
5NJ3
-
?
A:
[388-587]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
S
K
R
S
F
K
N
L
L
-
G
N
P
Q
A
S
-
I
A
Q
-
I
I
V
T
V
V
L
G
L
V
I
G
A
I
Y
F
G
L
K
--
N
---
D
S
T
G
I
Q
N
R
------------------
A
G
V
L
F
F
L
T
T
----
N
Q
C
F
S
----------
S
--------
V
S
A
V
E
-
L
F
V
V
E
K
K
L
F
I
H
E
Y
-
I
-
S
G
Y
---
Y
R
V
S
----
S
Y
F
L
-
G
K
L
L
S
D
L
L
----------
P
M
R
M
L
P
S
I
I
F
T
C
I
V
-
Y
F
M
-
L
-
G
L
--
K
P
------------------------------
K
A
D
A
F
F
-
V
------
M
M
F
---
T
-
L
M
M
V
A
---
Y
S
A
S
-
S
M
A
L
A
I
A
A
G
Q
-----
S
V
V
S
V
A
T
L
L
M
T
I
C
F
V
F
M
-
M
I
-
F
S
G
L
L
VNLTTIASWLS
W
L
-
Q
Y
F
S
I
P
R
Y
----
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
37.99
22%
-119
- C5 -
-
2V1N
-
A:
[15-41]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
D
Y
F
-
S
E
E
F
R
N
D
F
L
E
L
L
R
-
R
-
R
-
F
---
G
T
-
K
----
R
V
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
36.93
14%
-216
- C5 -
-
5DO7
-
ABCG8_HUMAN
B:
[472-602]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
C
Y
S
E
R
A
M
L
Y
Y
E
L
E
D
-
G
-
L
Y--
T
T
-
G
----
P
Y
F
F
-
A
K
I
L
G
E
L
-----------
P
E
H
C
A
Y
I
I
I
Y
G
M
P
T
-
Y
W
L
-
A
-
N
L
--
R
P
------------------------------
G
L
Q
P
F
L
-
L
------
H
F
L
---
L
-
V
W
L
V
V
---
F
C
C
R
-
I
M
A
L
A
A
A
A
L
L
-----
P
T
F
H
M
A
S
F
F
S
N
A
L
Y
N
S
F
-
Y
L
-
A
G
G
F
M
INLSSLWTV
P
A
W
I
-
S
K
V
S
F
L
R
W
----
C
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
36.67
33%
-114
- C8 -
-
5EZ4
1
?
D:
[420-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
F
E
--
T
E
Q
E
A
I
Q
L
-
A
------
N
D
S
---
I
-
Y
G
L
A
G
---
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
-----
K
L
K
L
G
T
V
W
I
N
D
F
H
M
L
F
A
-
Q
A
-
P
W
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
36.49
12%
-103
- C5 -
-
3FLO
-
DPOA_YEAST
B:
[11-190]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
E
R
F
K
-
D
T
V
-
T
L
E
L
S
C
P
S
C
D
K
R
F
P
F
G
G
I
V
S
S
N
---
Y
Y
R
V
S
Y
------------------------
N
G
L
Q
C
----
K
H
C
E
Q
----------
L
--------
F
T
P
L
Q
-
L
T
S
Q
I
E
H
S
I
R
A
H
I
-
S
-
L
-
Y
---
Y
A
-
G
----
W
L
Q
C
-
D
D
S
T
C
G
I
-----------
V
T
R
Q
V
S
V
F
G
K
R
C
L
N
-
D
G
C
-
T
G
V
M
R
Y
K
Y
S
---------
D
K
Q
L
Y
N
Q
L
L
Y
F
D
S
L
F
D
--
C
E
K
N
K
K
Q
E
-
L
------
K
P
I
---
Y
-
L
P
D
D
L
---
D
Y
P
K
-
E
Q
L
T
E
S
S
I
K
A
-----
L
T
E
Q
N
R
E
L
M
E
T
G
R
S
V
V
Q
-
K
Y
-
L
N
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
35.95
7%
-164
- C5 -
-
5DO7
-
ABCG5_HUMAN
A:
[370-546]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
R
R
V
T
R
N
L
V
-
R
N
K
L
A
V
-
I
T
R
-
L
L
Q
N
L
I
M
G
L
F
L
L
F
F
V
L
R
V
R
S
N
V
---
L
K
G
A
I
Q
D
R
V
G
----------------
L
L
Y
Q
F
V
G
A
T
----
P
Y
T
G
M
----------
L
--------
N
A
V
N
L
-
F
P
V
L
R
A
V
S
D
Q
E
S
Q
-
D
-
G
-
L
Y--
Q
K
-
W
----
Q
M
M
L
-
A
Y
A
L
H
V
L
-----------
P
F
S
V
V
A
T
M
I
F
S
S
V
C
-
Y
W
T
-
L
-
G
L
--
H
P
E
------------------------------
V
A
R
F
G
-
Y
------
F
S
A
---
A
-
L
L
A
P
H
---
L
I
G
E
-
F
L
T
L
V
L
L
G
I
V
-----
Q
N
P
N
I
V
N
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
35.35
33%
-108
- C8 -
-
5EZ4
1
?
A:
[420-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
F
E
--
T
E
Q
E
A
I
Q
L
-
A
------
N
D
S
---
I
-
Y
G
L
A
G
---
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
-----
K
L
K
L
G
T
V
W
I
N
D
F
H
M
L
F
A
-
Q
A
-
P
W
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
35.26
14%
-216
- C5 -
-
5DO7
-
ABCG8_HUMAN
D:
[472-602]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
C
Y
S
E
R
A
M
L
Y
Y
E
L
-
E
D
G
-
L
Y--
T
T
-
G
----
P
Y
F
F
-
A
K
I
L
G
E
L
-----------
P
E
H
C
A
Y
I
I
I
Y
G
M
P
T
-
Y
W
L
-
A
-
N
L
--
R
P
------------------------------
G
L
Q
P
F
L
-
L
------
H
F
L
---
L
-
V
W
L
V
V
---
F
C
C
R
-
I
M
A
L
A
A
A
A
L
L
-----
P
T
F
H
M
A
S
F
F
S
N
A
L
Y
N
S
F
-
Y
L
-
A
G
G
F
M
INLSSLWTVP
A
W
I
-
S
K
V
S
F
L
R
W
----
C
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
35.23
33%
-114
* C8 *
-
5EZ4
1
?
C:
[420-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
F
E
--
T
E
Q
E
A
I
Q
L
-
A
------
N
D
S
---
I
-
Y
G
L
A
G
---
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
-----
K
L
K
L
G
T
V
W
I
N
D
F
H
M
L
F
A
-
Q
A
-
P
W
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
34.93
33%
-107
- C8 -
-
4ZXU
1
?
A:
[420-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
F
E
--
T
E
Q
E
A
I
Q
L
-
A
------
N
D
S
---
I
-
Y
G
L
A
G
---
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
-----
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
-
Q
A
-
P
W
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
34.75
12%
-184
- C5 -
-
5XJY
-
?
A:
[672-1045]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
----------
V
--------
I
I
K
G
I
-
V
Y
E
K
E
A
R
L
K
E
T
M
R
-
I
-
M
G
L
---
D
N
-
S
----
I
L
W
F
-
S
W
F
I
S
S
------------
L
I
P
L
L
V
S
A
G
L
L
V
V
I
-
L
K
L
-
G
-
N
L
L
P
Y
-----------------------------
S
D
----
P
S
-
V
------
V
F
V
---
F
-
L
S
V
F
A
---
V
V
T
I
-
L
Q
C
F
L
I
S
T
L
F
-----
S
R
A
N
L
A
A
A
C
G
G
I
I
Y
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------