@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1276: (2018-01-08 )
MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQPDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE
Atome Classification :
(38 SA)
.........10......----.----.20........30........-40........50........60........70........80......--.---.90.....-...-100...-....110.......120-....---.-....130.----......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
Q
E
T
I
I
Q
E
LGVKPVI----
D
----
A
Q
E
E
I
R
R
S
I
D
F
L
K
R
Y
L
K
KHPF-
L
K
T
F
V
L
GISGGQD
S
T
L
A
G
R
L
A
Q
L
A
M
E
E
L
R
AETGDDS
Y
K
F
I
A
V
RLPYGV--Q---ADEA
D
A
Q
K
-
A
L
A
-FIQPD
V
-
S
L
V
V
N
IKESAD
A
M
T
A
---
A
V
EA---T-GSPVSDFN----KG
N
I
K
A
R
C
R
M
I
A
Q
Y
A
LAGSHS
G
A
V
I
GTDH
A
A
E
N
I
T
G
F
F
TKFGDGGA
D
I
L
P
L
Y
RL
N
K
R
Q
G
K
Q
L
L
Q
K
LGAE
P
A
L
Y
EKIPTADLEEDKPG
L
A
D
E
V
A
LGV
T
Y
A
E
I
D
D
Y
LEGKTIS
P
E
A
Q
A
T
I
E
N
W
W
HKGQHKRHL
P
I
T
V
F
D
DFWE
2
PsiBlast_PDB
92.34
76%
-79
- C6 -
-
5HUJ
-
?
A:
[34-307]
M
T
L
Q
E
E
I
I
R
Q
L
G
V
K
A
S
I
----
D
----
P
Q
E
E
I
R
K
T
V
D
F
L
K
A
Y
L
R
K
H
S
F
-
L
K
T
Y
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
A
Q
M
A
I
A
E
L
R
E
E
T
S
D
Q
A
Y
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
----
D
E
A
D
A
Q
K
-
A
L
A
-
F
I
A
P
D
Q
-
T
L
T
I
N
I
K
A
A
V
D
G
Q
V
E
---
A
L
Q
A
---
A
-
G
V
E
I
S
D
F
N
----
K
G
N
I
K
A
R
Q
R
M
I
S
Q
Y
A
I
A
G
Q
M
A
G
A
V
I
G
T
D
H
A
A
E
N
I
T
G
F
F
T
K
F
G
D
G
G
A
D
I
L
P
L
F
R
L
N
K
R
Q
G
K
A
L
L
K
V
L
G
A
D
A
A
L
Y
E
-------------
L
A
D
E
V
A
L
G
V
T
Y
Q
D
I
D
D
Y
L
E
G
K
L
I
S
K
V
A
Q
A
T
I
E
K
W
W
H
K
G
Q
H
K
R
H
L
P
I
T
I
F
A
D
F
W
K
1
PsiBlast_PDB
92.19
76%
-75
- C6 -
-
5HUH
-
?
A:
[34-307]
M
T
L
Q
E
E
I
I
R
Q
L
G
V
K
A
S
I
----
D
----
P
Q
E
E
I
R
K
T
V
D
F
L
K
A
Y
L
R
K
H
S
F
-
L
K
T
Y
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
A
Q
M
A
I
A
E
L
R
E
E
T
S
D
Q
A
Y
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
A
D
A
Q
K
-
A
L
A
-
F
I
A
P
D
Q
-
T
L
T
I
N
I
K
A
A
V
D
G
Q
V
E
---
A
L
Q
A
---
A
-
G
V
E
I
S
D
F
N
----
K
G
N
I
K
A
R
Q
R
M
I
S
Q
Y
A
I
A
G
Q
M
A
G
A
V
I
G
T
D
H
A
A
E
N
I
T
G
F
F
T
K
F
G
D
G
G
A
D
I
L
P
L
F
R
L
N
K
R
Q
G
K
A
L
L
K
V
L
G
A
D
A
A
L
Y
E
-------------
L
A
D
E
V
A
L
G
V
T
Y
Q
D
I
D
D
Y
L
E
G
K
L
I
S
K
V
A
Q
A
T
I
E
K
W
W
H
K
G
Q
H
K
R
H
L
P
I
T
I
F
A
D
F
W
K
7
PsiBlast_PDB
89.79
66%
-78
- C6 -
-
1WXI
3
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
K
A
-------------
D
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
6
PsiBlast_PDB
89.74
66%
-87
- C6 -
-
1WXH
1
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--------
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
8
PsiBlast_PDB
89.45
66%
-70
- C6 -
-
3HMQ
1
NADE_SALTY
A:
[2-274]
-
T
L
Q
Q
E
I
I
Q
A
L
G
A
K
P
H
I
----
N
----
P
E
E
E
I
R
R
S
V
D
F
L
K
A
Y
L
K
T
Y
P
F
-
L
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
S
Q
M
A
I
A
E
L
R
E
E
T
G
D
N
A
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
H
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
H
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
G
C
P
E
H
L
Y
K
K
-------------
P
D
E
A
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
T
L
D
P
A
I
A
K
T
I
E
G
W
Y
V
K
T
E
H
K
R
R
L
P
I
T
V
F
D
D
F
W
K
3
PsiBlast_PDB
89.38
66%
-87
- C6 -
-
1WXE
2
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
4
PsiBlast_PDB
88.53
66%
-85
- C6 -
-
1WXF
-
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--------
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
5
PsiBlast_PDB
88.03
66%
-84
- C6 -
-
1WXG
1
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
Y
P
F
-
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--------
E
Q
D
C
Q
D
-
A
I
A
-
F
I
Q
P
D
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
----------------
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
59
HHSearch
85.43
76%
-23
- C6 -
-
5HUJ
-
?
B:
[37-307]
---
Q
E
E
I
I
R
Q
L
G
V
K
A
S
I
----
D
----
P
Q
E
E
I
R
K
T
V
D
F
L
K
A
Y
L
R
K
H
S
F
-
L
K
T
Y
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
A
Q
M
A
I
A
E
L
R
E
E
T
S
D
Q
A
Y
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
----
D
E
A
D
A
Q
K
-
A
L
A
F
I
A
P
-
D
Q
-
T
L
T
I
N
I
K
A
A
V
D
G
Q
V
E
---
A
L
Q
A
---
A
-
G
V
E
I
S
D
F
N
----
K
G
N
I
K
A
R
Q
R
M
I
S
Q
Y
A
I
A
G
Q
M
A
G
A
V
I
G
T
D
H
A
A
E
N
I
T
G
F
F
T
K
F
G
D
G
G
A
D
I
L
P
L
F
R
L
N
K
R
Q
G
K
A
L
L
K
V
L
G
A
D
A
A
L
Y
E
-------------
L
A
D
E
V
A
L
G
V
T
Y
Q
D
I
D
D
Y
L
E
G
K
L
I
S
K
V
A
Q
A
T
I
E
K
W
W
H
K
G
Q
H
K
R
H
L
P
I
T
I
F
A
D
F
W
K
60
HHSearch
84.64
76%
-21
- C6 -
-
5HUH
-
?
A:
[37-307]
---
Q
E
E
I
I
R
Q
L
G
V
K
A
S
I
----
D
----
P
Q
E
E
I
R
K
T
V
D
F
L
K
A
Y
L
R
K
H
S
F
-
L
K
T
Y
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
A
Q
M
A
I
A
E
L
R
E
E
T
S
D
Q
A
Y
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
A
D
A
Q
K
-
A
L
A
F
I
A
P
-
D
Q
-
T
L
T
I
N
I
K
A
A
V
D
G
Q
V
E
---
A
L
Q
A
---
A
-
G
V
E
I
S
D
F
N
----
K
G
N
I
K
A
R
Q
R
M
I
S
Q
Y
A
I
A
G
Q
M
A
G
A
V
I
G
T
D
H
A
A
E
N
I
T
G
F
F
T
K
F
G
D
G
G
A
D
I
L
P
L
F
R
L
N
K
R
Q
G
K
A
L
L
K
V
L
G
A
D
A
A
L
Y
E
-------------
L
A
D
E
V
A
L
G
V
T
Y
Q
D
I
D
D
Y
L
E
G
K
L
I
S
K
V
A
Q
A
T
I
E
K
W
W
H
K
G
Q
H
K
R
H
L
P
I
T
I
F
A
D
F
W
K
18
PsiBlast_PDB
81.85
60%
-25
- C6 -
-
4Q16
-
NADE_DEIRA
A:
[11-280]
--
L
R
S
H
I
I
R
E
L
H
V
Q
P
D
I
----
D
----
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
T
P
--
T
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
A
D
A
Q
Q
-
A
L
D
-
F
I
Q
A
D
R
-
E
V
T
V
N
I
K
E
A
A
D
A
S
V
A
---
A
A
Q
A
---
A
L
G
S
E
V
R
D
F
V
----
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
R
K
V
P
T
A
D
L
----
P
G
L
P
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
F
D
G
W
W
Q
17
PsiBlast_PDB
79.96
56%
-5
- C6 -
-
1KQP
8
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
12
PsiBlast_PDB
79.52
56%
-5
- C6 -
-
2NSY
6
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
43
Fugue
79.44
57%
-3
- C6 -
-
2NSY
6
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
A
--
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
--
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
---
E
T
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
25
PsiBlast_CBE
79.41
58%
-18
- C6 -
-
2PZ8
2
NADE_BACAN
B:
[1-272]
M
T
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
----
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
---
K
D
E
D
D
A
Q
L
-
A
L
Q
-
F
I
Q
A
D
Q
-
S
V
A
F
D
I
A
S
T
V
D
A
F
S
N
---
Q
Y
E
N
---
L
L
D
E
S
L
T
D
F
N
----
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
28
PsiBlast_CBE
79.28
56%
-4
- C6 -
-
1KQP
11
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
16
PsiBlast_PDB
79.16
56%
-7
- C6 -
-
1IH8
1
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
9
PsiBlast_PDB
79.06
58%
-15
- C6 -
-
2PZ8
2
NADE_BACAN
A:
[1-272]
M
T
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
----
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
---
K
D
E
D
D
A
Q
L
-
A
L
Q
-
F
I
Q
A
D
Q
-
S
V
A
F
D
I
A
S
T
V
D
A
F
S
N
---
Q
Y
E
N
---
L
L
D
E
S
L
T
D
F
N
----
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
24
PsiBlast_CBE
78.91
58%
-19
- C6 -
-
2PZA
3
NADE_BACAN
B:
[1-272]
M
T
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
----
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
---
K
D
E
D
D
A
Q
L
-
A
L
Q
-
F
I
Q
A
D
Q
-
S
V
A
F
D
I
A
S
T
V
D
A
F
S
N
---
Q
Y
E
N
---
L
L
D
E
S
L
T
D
F
N
----
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
62
HHSearch
78.81
60%
-7
* C6 *
-
4Q16
-
NADE_DEIRA
D:
[10-280]
-
P
L
R
S
H
I
I
R
E
L
H
V
Q
P
D
I
----
D
----
P
G
A
E
V
E
R
R
V
A
F
L
C
D
Y
L
Q
S
-
T
P
-
T
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
C
Q
L
A
V
E
R
R
R
S
Q
--
G
H
G
A
T
F
L
A
V
R
L
P
Y
G
V
--
Q
---
A
D
E
A
D
A
Q
Q
-
A
L
D
-
F
I
Q
-
A
D
R
E
V
T
V
N
I
K
E
A
A
D
A
S
V
A
---
A
A
Q
A
---
A
L
G
S
E
V
R
D
F
V
----
R
G
N
V
K
A
R
E
R
M
V
A
Q
Y
A
L
A
G
Q
E
N
L
L
V
V
G
T
D
H
A
A
E
A
L
T
G
F
Y
T
K
Y
G
D
G
G
V
D
L
T
P
L
S
G
L
T
K
R
Q
G
A
Q
L
L
A
H
L
G
A
P
E
G
T
W
R
K
V
P
T
A
D
----
R
P
G
L
P
D
E
V
A
L
G
V
T
Y
A
Q
I
D
A
Y
L
E
G
R
E
V
S
D
E
A
A
A
R
L
E
R
L
F
L
N
S
R
H
K
R
A
L
P
V
T
P
F
D
G
W
W
Q
54
HHSearch
78.77
63%
-15
- C6 -
-
1WXI
3
NADE_ECOLI
A:
[2-274]
-
T
L
Q
Q
Q
I
I
K
A
L
G
A
K
P
Q
I
----
N
----
A
E
E
E
I
R
R
S
V
D
F
L
K
S
Y
L
Q
T
-
Y
P
F
I
K
S
L
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
K
L
C
Q
M
A
I
N
E
L
R
L
E
T
G
N
E
S
L
Q
F
I
A
V
R
L
P
Y
G
V
--
Q
AD
E
Q
D
C
Q
D
A
I
A
-
F
I
Q
-
P
D
---
R
-
V
L
T
V
N
I
K
G
A
V
L
A
S
E
Q
---
A
L
R
E
---
A
-
G
I
E
L
S
D
F
V
----
R
G
N
E
K
A
R
E
R
M
K
A
Q
Y
S
I
A
G
M
T
S
G
V
V
V
G
T
D
H
A
A
E
A
I
T
G
F
F
T
K
Y
G
D
G
G
T
D
I
N
P
L
Y
R
L
N
K
R
Q
G
K
Q
L
L
A
A
L
A
C
P
E
H
L
Y
K
K
A
-------------
D
E
V
A
L
G
V
T
Y
D
N
I
D
D
Y
L
E
G
K
N
V
P
Q
Q
V
A
R
T
I
E
N
W
Y
L
K
T
E
H
K
R
R
P
P
I
T
V
F
D
D
F
W
K
26
PsiBlast_CBE
78.42
56%
-4
- C6 -
-
2NSY
6
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
58
HHSearch
78.40
57%
-4
- C6 -
-
1KQP
11
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
-
T
G
-
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
--
G
G
D
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
---
E
T
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
13
PsiBlast_PDB
78.26
56%
-8
- C6 -
-
1EE1
3
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
14
PsiBlast_PDB
78.05
56%
-8
- C6 -
-
1FYD
2
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
10
PsiBlast_PDB
78.00
58%
-15
- C6 -
-
2PZA
3
NADE_BACAN
A:
[1-272]
M
T
L
Q
E
Q
I
M
K
A
L
H
V
Q
P
V
I
----
D
----
P
K
A
E
I
R
K
R
V
D
F
L
K
D
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
E
I
R
N
E
G
G
N
A
T
--
F
I
A
V
R
L
P
Y
K
V
--
Q
---
K
D
E
D
D
A
Q
L
-
A
L
Q
-
F
I
Q
A
D
Q
-
S
V
A
F
D
I
A
S
T
V
D
A
F
S
N
---
Q
Y
E
N
---
L
L
D
E
S
L
T
D
F
N
----
K
G
N
V
K
A
R
I
R
M
V
T
Q
Y
A
I
G
G
Q
K
G
L
L
V
I
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
F
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
A
L
L
Q
E
L
G
A
D
E
R
L
Y
L
K
M
P
T
A
D
L
L
D
E
K
P
G
Q
A
D
E
T
E
L
G
I
T
Y
D
Q
L
D
D
Y
L
E
G
K
T
V
P
A
D
V
A
E
K
I
E
K
R
Y
T
V
S
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
11
PsiBlast_PDB
77.82
56%
-8
- C6 -
-
1NSY
4
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
27
PsiBlast_CBE
77.69
56%
-5
- C6 -
-
1NSY
4
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
57
HHSearch
77.45
57%
-7
- C6 -
-
1NSY
4
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
-
T
G
-
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
--
G
G
D
A
Q
F
I
A
V
R
L
P
H
G
T
--
Q
---
Q
D
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
---
E
T
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
K
E
P
T
A
D
L
L
D
E
K
P
Q
Q
S
D
E
T
E
L
G
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
31
PsiBlast_CBE
77.28
56%
-32
- C6 -
-
1EE1
2
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
---------
E
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
30
PsiBlast_CBE
77.17
56%
-35
- C6 -
-
1IFX
2
NADE_BACSU
B:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
----------
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
15
PsiBlast_PDB
75.95
56%
-28
- C6 -
-
1IFX
2
NADE_BACSU
A:
[1-271]
-
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
S
I
----
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
--
A
K
G
F
V
L
G
I
S
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
--
A
Q
F
I
A
V
R
L
P
H
G
----------
D
D
A
Q
L
-
A
L
K
-
F
I
K
P
D
K
-
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
---
Q
Y
Q
Q
E
--
T
-
G
D
Q
L
T
D
F
N
----
K
G
N
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
L
V
L
G
T
D
H
A
A
E
A
V
T
G
F
F
T
K
Y
G
D
G
G
A
D
L
L
P
L
T
G
L
T
K
R
Q
G
R
T
L
L
K
E
L
G
A
P
E
R
L
Y
L
---------------------
I
S
Y
D
E
I
D
D
Y
L
E
G
K
E
V
S
A
K
V
S
E
A
L
E
K
R
Y
S
M
T
E
H
K
R
Q
V
P
A
S
M
F
D
D
W
W
K
20
PsiBlast_PDB
72.98
54%
-8
- C6 -
-
5F23
2
NADE_PSEAE
A:
[12-280]
--
I
Q
R
D
I
A
Q
A
L
Q
V
Q
P
P
F
QS
E
A
D
----
V
Q
A
Q
I
A
R
R
I
A
F
I
Q
Q
C
L
K
D
S
-
G
-
L
K
T
L
V
L
G
I
S
G
G
V
D
S
L
T
A
G
L
L
A
Q
R
A
V
E
Q
L
R
E
Q
T
G
D
Q
A
Y
R
F
I
A
V
R
L
P
Y
Q
V
--
Q
---
Q
D
E
A
D
A
Q
A
-
S
L
A
-
T
I
R
A
D
E
-
E
Q
T
V
N
I
G
P
S
V
K
A
L
A
E
Q
LE
A
L
E
G
---
L
-
E
P
A
K
S
D
F
V
----
I
G
N
I
K
A
R
I
R
M
V
A
Q
Y
A
I
A
G
A
R
G
G
L
V
I
G
T
D
H
A
A
E
A
V
M
G
F
F
T
K
F
G
D
G
A
C
D
L
A
P
L
S
G
L
A
K
H
Q
V
R
A
L
A
R
A
L
G
A
P
E
N
L
V
E
K
I
-----------------
H
G
V
T
Y
A
E
I
D
A
F
L
H
G
Q
P
L
R
E
E
A
A
R
V
I
V
D
T
Y
H
K
T
Q
H
K
R
E
L
P
---------
65
HHSearch
70.45
54%
-1
- C6 -
-
5F23
2
NADE_PSEAE
A:
[11-283]
-
Q
I
Q
R
D
I
A
Q
A
L
Q
V
Q
P
P
F
----
Q
S
E
A
D
V
Q
A
Q
I
A
R
R
I
A
F
I
Q
Q
C
L
K
D
-
S
G
-
L
K
T
L
V
L
G
I
S
G
G
V
D
S
L
T
A
G
L
L
A
Q
R
A
V
E
Q
L
R
E
Q
T
G
D
Q
A
Y
R
F
I
A
V
R
L
P
Y
Q
V
--
Q
---
Q
D
E
A
D
A
Q
A
S
L
A
T
-
I
R
A
-
D
E
-
E
Q
T
V
N
I
G
P
S
V
K
A
L
A
E
---
Q
L
E
A
LEG
L
-
E
P
A
K
S
D
F
V
----
I
G
N
I
K
A
R
I
R
M
V
A
Q
Y
A
I
A
G
A
R
G
G
L
V
I
G
T
D
H
A
A
E
A
V
M
G
F
F
T
K
F
G
D
G
A
C
D
L
A
P
L
S
G
L
A
K
H
Q
V
R
A
L
A
R
A
L
G
A
P
E
N
L
V
E
K
I
-----------------
H
G
V
T
Y
A
E
I
D
A
F
L
H
G
Q
P
L
R
E
E
A
A
R
V
I
V
D
T
Y
H
K
T
Q
H
K
R
E
L
P
K
A
P
------
37
PsiBlast_CBE
68.13
36%
-31
- C6 -
-
3FIU
2
?
C:
[10-246]
---------------------------
K
E
Y
S
Q
K
L
V
N
W
L
S
D
S
C
M
N
Y
P
--
A
E
G
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
--------
V
K
T
G
L
P
T
---
T
A
L
I
L
P
-
S
D
--
N
---
N
Q
H
Q
D
M
Q
D
-
A
L
E
-
L
I
E
------
M
L
N
I
E
H
Y
T
I
S
I
Q
P
---
A
Y
E
A
---
F
-
L
A
S
T
Q
S
F
T
QLVI
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
-------
39
PsiBlast_CBE
67.73
36%
-32
- C6 -
-
3FIU
2
?
A:
[10-246]
---------------------------
K
E
Y
S
Q
K
L
V
N
W
L
S
D
S
C
M
N
Y
P
--
A
E
G
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
--------
V
K
T
G
L
P
T
---
T
A
L
I
L
P
-
S
D
--
N
---
N
Q
H
Q
D
M
Q
D
-
A
L
E
-
L
I
E
------
M
L
N
I
E
H
Y
T
I
S
I
Q
P
---
A
Y
E
A
---
F
-
L
A
S
T
Q
S
F
T
Q
L
V
I
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
-------
38
PsiBlast_CBE
66.97
36%
-30
- C6 -
-
3FIU
2
?
B:
[10-246]
---------------------------
K
E
Y
S
Q
K
L
V
N
W
L
S
D
S
C
M
N
Y
P
--
A
E
G
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
--------
V
K
T
G
L
P
T
---
T
A
L
I
L
P
-
S
D
--
N
---
N
Q
H
Q
D
M
Q
D
-
A
L
E
-
L
I
E
------
M
L
N
I
E
H
Y
T
I
S
I
Q
P
---
A
Y
E
A
---
F
-
L
A
S
T
Q
S
F
T
QLVI
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
Q
---
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
-------
67
HHSearch
63.57
36%
-18
- C6 -
-
3FIU
2
?
B:
[6-247]
---------------
D
F
----
S
----
P
K
E
Y
S
Q
K
L
V
N
W
L
S
D
S
C
M
N
-
Y
P
-
A
E
G
F
V
I
G
L
S
G
G
I
D
S
A
V
A
A
S
L
A
V
K
T
G
L
-----------
P
T
T
A
L
I
L
P
S
D
N
NQ
H
---
Q
D
M
Q
D
A
L
E
-
L
I
E
-
M
L
N
-
I
E
-
H
Y
T
I
S
I
Q
P
A
Y
E
A
F
L
A
---
S
T
Q
S
FT-------
Q
L
V
I
----
K
G
N
A
Q
A
R
L
R
M
M
Y
L
Y
A
Y
A
Q
Q
Y
N
R
I
V
I
G
T
D
N
A
C
E
W
Y
M
G
Y
F
T
K
F
G
D
G
A
A
D
I
L
P
L
V
N
L
K
K
S
Q
V
F
E
L
G
K
Y
L
D
V
P
K
N
I
L
D
K
A
P
S
A
G
L
W
---
Q
G
Q
T
D
E
D
E
M
G
V
T
Y
Q
E
I
D
D
F
L
D
G
K
Q
V
S
A
K
A
L
E
R
I
N
F
W
H
N
R
S
H
H
K
R
K
L
A
L
T
P
------