@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLA9: (2017-11-01 )
MSKQILILAGDGIGPEIVGAAEKVLNKVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIERSIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIRELENGEKQGYNTDVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQANYPNIQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDAVGQVLDQGLRTADIMSEGMTKVGTAEMGEAVVAALA
Atome Classification :
(53 SA)
.........10........20........30........40........---50..-......60...-.....70........80.....-...90-........100.......110.......120..-.-.-...130.......140....------...150----..----...-..160.......170.......180.-----...--------...190.......200........210-........220.......230.......240.......250.......260.......270-........280.......290.......300.......----310----..-.......320.......330.......--.340--....--...350.......--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
K
Q
I
L
I
L
AGDGI
G
P
E
I
V
G
A
A
E
K
V
L
N
K
VNEKF
N
L
S
L
T
WEHGLLG
G
A
A
ID---AHGE-PYPAV
T
S
E
Q
AK-KA
D
A
I
L
L
GAVGGPK
W
D
T
I
E
R
SI-RPE
R
G
-
L
L
K
I
R
S
E
L
N
L
F
ANL
R
P
A
ILYPQLADASSLK
P
E
I
-V-A-G
L
D
I
L
I
V
R
E
LTG
G
I
YFGQPR------G
I
R
E
L
E----NG----EKQ-GYNTDVY
S
E
S
E
I
K
R
I
A
K
V
A
F
E
L
AGLR-----GG
K
--------
V
C
SVDK
A
N
V
L
E
V
T
E
-
L
W
K
Q
T
V
T
D
L
Q
Q--ANYPN
I
Q
L
S
H
M
YV
D
N
A
A
M
Q
L
VRAP
K
Q
F
D
V
I
V
TG
N
L
F
G
D
I
LSD
E
A
A
M
LTGSIGMLPSASLD--ENGKGMYEPCHGSAPDIAGQNV
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
Y
----
T
------
F
R
-
E
E
A
A
A
K
A
I
E
D
A
V
G
Q
V
L
D
Q
G-L
R
T
A
D
I
M
--
S
E
G
M
--
T
KV
G
--
T
A
E
M
G
E
A
V
V
A
ALA--
137
HHSearch
89.66
60%
-94
* C7 *
-
5J34
-
LEU32_ARATH
D:
[41-398]
K
R
Y
T
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
M
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
A
---
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
D
--
7
PsiBlast_PDB
89.48
60%
-98
- C7 -
-
5J34
-
LEU32_ARATH
A:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
M
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
1
PsiBlast_PDB
89.04
62%
-108
- C7 -
-
1A05
2
LEU3_ACIFR
A:
[2-354]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
S
D
D
-
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
A
K
-
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
L
-
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
------
G
L
-
E
V
I
----
D
G
----
K
R
R
-
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-----
R
K
Q
--------
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
R
E
V
V
T
E
V
A
R
---
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
--
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
------
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
D
I
A
--
A
P
G
T
--
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
---
139
HHSearch
88.66
62%
-107
- C7 -
-
1A05
2
LEU3_ACIFR
A:
[1-355]
-
M
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
S
D
D
-
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
A
K
-
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
L
-
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
------
G
L
E
V
I
D
-----
G
----
K
R
R
-
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-----
R
K
Q
--------
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
R
E
V
V
T
E
V
A
---
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
--
E
G
-
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
------
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
D
I
A
--
A
P
G
T
--
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
--
4
PsiBlast_PDB
88.58
60%
-96
- C7 -
-
3R8W
-
LEU32_ARATH
A:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
34
PsiBlast_CBE
88.53
60%
-96
- C7 -
-
5J32
2
LEU32_ARATH
D:
[43-395]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
21
PsiBlast_CBE
88.52
62%
-106
- C7 -
-
1A05
2
LEU3_ACIFR
B:
[2-354]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
S
D
D
-
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
A
K
-
R
P
E
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
L
-
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
------
G
L
-
E
V
I
----
D
G
----
K
R
R
-
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-----
R
K
Q
--------
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
R
E
V
V
T
E
V
A
R
---
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
--
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
------
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
D
I
A
--
A
P
G
T
--
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
---
138
HHSearch
88.34
60%
-90
- C7 -
-
5J32
2
LEU32_ARATH
A:
[39-396]
K
R
Y
T
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
A
---
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
D
--
25
PsiBlast_CBE
88.29
60%
-97
- C7 -
-
5J33
1
LEU32_ARATH
G:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
30
PsiBlast_CBE
88.25
60%
-96
- C7 -
-
5J33
2
LEU32_ARATH
B:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
35
PsiBlast_CBE
87.94
60%
-93
- C7 -
-
5J32
2
LEU32_ARATH
C:
[43-394]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
----
24
PsiBlast_CBE
87.83
60%
-93
- C7 -
-
5J33
1
LEU32_ARATH
H:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
6
PsiBlast_PDB
87.77
60%
-95
- C7 -
-
5J32
2
LEU32_ARATH
A:
[43-395]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
5
PsiBlast_PDB
87.77
60%
-95
- C7 -
-
5J33
2
LEU32_ARATH
A:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
36
PsiBlast_CBE
87.74
60%
-97
- C7 -
-
5J32
2
LEU32_ARATH
B:
[43-395]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
8
PsiBlast_PDB
87.64
58%
-106
- C7 -
-
3U1H
-
?
A:
[3-355]
--
K
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
F
E
F
E
Y
G
L
I
G
G
A
A
I
D
---
E
A
G
T
-
P
L
P
E
E
T
L
D
V
C
R
-
G
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
Q
N
P
S
E
L
-
R
P
E
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
V
-
I
-
E
-
G
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
---------------
E
----
E
G
----
E
E
A
-
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
R
-----
K
K
K
--------
V
T
S
V
D
K
A
N
V
L
E
S
S
R
-
L
W
R
E
V
A
E
E
V
A
K
---
E
Y
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
--
T
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
L
R
Y
----
S
------
F
G
-
L
E
E
E
A
K
A
I
E
K
A
V
E
K
V
L
A
E
G
-
Y
R
T
A
D
I
A
--
K
P
G
G
--
K
Y
V
S
--
T
T
E
M
T
D
E
V
K
A
A
V
---
29
PsiBlast_CBE
87.54
60%
-95
- C7 -
-
5J33
1
LEU32_ARATH
C:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
27
PsiBlast_CBE
87.21
60%
-96
- C7 -
-
5J33
1
LEU32_ARATH
E:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
28
PsiBlast_CBE
87.12
60%
-92
- C7 -
-
5J33
2
LEU32_ARATH
D:
[45-397]
----
I
T
L
L
P
G
D
G
I
G
P
E
V
V
S
I
A
K
N
V
L
Q
Q
A
G
S
L
E
G
V
E
F
N
F
R
E
M
P
I
G
G
A
A
L
D
---
L
V
G
V
-
P
L
P
E
E
T
I
S
A
A
K
-
E
S
D
A
V
L
L
G
A
I
G
G
Y
K
W
D
N
N
E
K
H
L
-
R
P
E
K
G
-
L
L
Q
I
R
A
A
L
K
V
F
A
N
L
R
P
A
T
V
L
P
Q
L
V
D
A
S
T
L
K
R
E
V
-
A
-
E
-
G
V
D
L
M
V
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
I
K
T
N
E
----
N
G
----
E
E
V
-
G
F
N
T
E
V
Y
A
A
H
E
I
D
R
I
A
R
V
A
F
E
T
A
R
K
R
-----
R
G
K
--------
L
C
S
V
D
K
A
N
V
L
E
A
S
I
-
L
W
R
K
R
V
T
A
L
-
A
--
S
E
Y
P
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
V
R
D
P
K
Q
F
D
T
I
V
T
N
N
I
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
I
G
M
L
P
S
A
S
L
S
--
D
S
G
P
G
L
F
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
A
A
M
L
L
K
Y
----
G
------
L
G
-
E
E
K
A
A
K
R
I
E
D
A
V
L
V
A
L
N
N
G
-
F
R
T
G
D
I
Y
--
S
A
G
T
--
K
L
V
G
--
C
K
E
M
G
E
E
V
L
K
S
V
---
22
PsiBlast_CBE
86.66
62%
-51
- C7 -
-
4XXV
3
LEU3_BURTA
B:
[10-363]
---
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
F
E
L
----
E
H
A
P
V
G
G
A
G
Y
E
---
A
S
G
H
-
P
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
A
L
-
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
L
-
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
Q
P
R
------
G
V
R
A
A
P
----
D
G
PFAG
E
R
E
-
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
-----
A
K
K
--------
L
L
S
V
D
K
S
N
V
L
E
T
S
Q
-
F
W
R
D
V
M
I
D
V
S
K
---
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
--
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
----
S
------
L
N
-
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
R
T
G
D
I
A
--
T
P
G
C
--
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---
144
HHSearch
85.04
63%
-39
- C7 -
-
4XXV
3
LEU3_BURTA
B:
[9-363]
--
M
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
----
E
K
F
E
L
E
H
A
P
V
G
G
A
G
Y
E
---
A
S
G
H
-
P
L
P
D
A
T
L
A
L
A
K
-
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
L
E
R
A
L
-
R
P
E
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
L
-
V
-
A
-
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
Q
P
R
------
G
V
R
A
A
P
DGPF
A
G
----
E
R
E
-
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
-----
A
K
K
--------
L
L
S
V
D
K
S
N
V
L
E
T
S
Q
-
F
W
R
D
V
M
I
D
V
S
---
K
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
--
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
-----------
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
R
T
G
D
I
A
--
T
P
G
C
--
R
Q
V
G
--
T
A
A
M
G
D
A
V
V
A
A
L
---
136
HHSearch
81.96
54%
-101
- C7 -
-
2Y3Z
7
LEU3_THET8
A:
[3-348]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
-------------
A
E
-
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
---
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
--
R
G
-
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
L
E
T
--
P
P
P
D
L
G
--
G
S
------
A
G
--
T
E
A
F
T
A
T
V
L
R
H
L
A
--
54
PsiBlast_CBE
81.40
55%
-110
- C7 -
-
4WUO
14
LEU3_THET8
A:
[3-322]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
126
Fugue
81.28
63%
-15
- C7 -
-
1A05
2
LEU3_ACIFR
A:
[1-357]
-
M
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
D
---
A
S
D
-D
P
L
P
A
A
S
L
Q
L
A
M
-
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
Y
P
P
A
K
-
R
P
E
-
Q
G
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
L
-
V
-
R
-
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
Q
P
R
G
L
E
V
I
D-----------
G
----
K
R
R
-
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
-----
R
K
Q
--------
L
C
S
V
D
K
A
N
V
L
E
T
T
R
-
L
W
R
E
V
V
T
E
V
A
R
---
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
--
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
----
S
------
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
D
I
A
AP--
G
T
--
P
V
I
G
--
T
K
A
M
G
A
A
V
V
N
A
L
N
LK
50
PsiBlast_CBE
80.05
55%
-104
- C7 -
-
1HEX
1
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
17
PsiBlast_PDB
79.94
55%
-104
- C7 -
-
2Y41
2
LEU3_THET8
A:
[3-322]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
53
PsiBlast_CBE
79.75
55%
-108
- C7 -
-
4WUO
7
LEU3_THET8
B:
[4-322]
--
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
47
PsiBlast_CBE
79.69
55%
-102
- C7 -
-
2Y41
2
LEU3_THET8
B:
[3-322]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
15
PsiBlast_PDB
79.49
55%
-106
- C7 -
-
2Y3Z
7
LEU3_THET8
A:
[3-322]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
49
PsiBlast_CBE
79.09
55%
-101
- C7 -
-
2ZTW
2
LEU3_THET8
A:
[2-319]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
D
---
A
F
G
E
-
P
F
P
E
P
T
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
L
P
R
K
I
-
R
P
E
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
I
-
A
-
R
-
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
R
------
G
M
S
E
A
E
--------------
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
-----
R
K
H
--------
V
V
S
V
D
K
A
N
V
L
E
V
G
E
-
F
W
R
K
T
V
E
E
V
G
R
---
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
---
R
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
----
A
------
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
----------------------------------------
73
PsiBlast_CBE
78.24
50%
-13
- C7 -
-
3WZX
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
52
PsiBlast_CBE
78.24
51%
-14
- C7 -
-
3VMK
2
?
A:
[15-372]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
N
D
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
-
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
N
E
E
-
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
E
V
V
E
E
V
A
K
---
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
------
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
E
L
L
PA
S
E
R
S
--
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
A
--
72
PsiBlast_CBE
77.96
50%
-11
- C7 -
-
3WZY
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
65
PsiBlast_CBE
77.66
50%
-11
- C7 -
-
3VL7
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
64
PsiBlast_CBE
77.57
50%
-13
- C7 -
-
3VMJ
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
70
PsiBlast_CBE
77.47
50%
-11
- C7 -
-
3VKZ
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
66
PsiBlast_CBE
77.46
50%
-9
- C7 -
-
3VL6
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
68
PsiBlast_CBE
77.37
50%
-11
- C7 -
-
3VL3
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
51
PsiBlast_CBE
77.35
51%
-13
- C7 -
-
3VMK
2
?
B:
[15-372]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
N
D
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
-
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
N
E
E
-
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
E
V
V
E
E
V
A
K
---
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
------
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
E
L
L
PA
S
E
R
S
--
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
A
--
67
PsiBlast_CBE
77.32
50%
-12
- C7 -
-
3VL4
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
63
PsiBlast_CBE
77.16
50%
-15
- C7 -
-
3WZV
1
?
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
71
PsiBlast_CBE
77.06
50%
-16
- C7 -
-
3VML
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
N
D
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
-
S
E
K
-
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
N
E
E
-
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
E
V
V
E
E
V
A
K
---
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
------
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
62
PsiBlast_CBE
77.04
50%
-10
- C7 -
-
3WZW
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
69
PsiBlast_CBE
76.87
50%
-12
- C7 -
-
3VL2
1
LEU3_SHEON
A:
[15-371]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
L
P
P
N
E
-
Q
P
E
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
-
S
-
A
R
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
-
R
Q
G
E
----
G
E
----
S
E
E
-
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
Q
V
V
E
E
V
A
---
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
--
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
----
S
------
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
E
L
L
--
S
S
D
Q
--
R
H
K
A
KT
T
V
Q
M
G
D
F
I
A
D
A
V
---
147
HHSearch
76.17
50%
-15
- C7 -
-
3VMK
2
?
B:
[13-372]
-
S
Y
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
D
---
N
H
G
C
-
P
L
P
E
A
T
L
K
G
C
E
-
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
L
P
P
N
D
Q
P
E
R
G
A
-
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
I
S
E
-
K
-
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
K
P
K
------
G
R
Q
G
E
-----
G
E
----
N
E
E
-
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
-----
R
K
K
--------
V
T
S
V
D
K
A
N
V
L
A
C
S
V
-
L
W
R
E
V
V
E
E
V
A
---
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
--
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
----
S
------
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
E
L
L
--
P
A
S
E
RS
Q
A
K
S
--
T
S
Q
M
G
D
Y
I
A
Q
A
I
A
--
110
PsiBlast_CBE
66.22
35%
-116
- C7 -
-
5HN4
3
?
A:
[3-277]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
-
Y
E
G
G
V
---
D
V
F
Q
---
E
C
G
S
-
P
I
R
E
E
D
L
E
E
I
R
-
R
S
D
A
V
L
F
G
A
T
T
T
P
F
D
L
P
G
Y
R
S
L
-------
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
-------------
I
I
P
D
L
-
R
-
T
-
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
----------
I
G
A
V
V
----
N
G
------
R
-
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
-----
G
S
F
--------
I
T
F
V
H
K
A
N
V
L
T
G
D
K
-
F
F
R
R
I
V
R
E
V
----
A
G
E
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
---
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
D
Y
----------------------------------------------------------------------
108
PsiBlast_CBE
65.79
35%
-114
- C7 -
-
5HN6
2
?
A:
[3-277]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
-
Y
E
G
G
V
---
D
V
F
Q
---
E
C
G
S
-
P
I
R
E
E
D
L
E
E
I
R
-
R
S
D
A
V
L
F
G
A
T
T
T
P
F
D
L
P
G
Y
R
S
L
-------
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
-------------
I
I
P
D
L
-
R
-
T
-
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
----------
I
G
A
V
V
----
N
G
------
R
-
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
-----
G
S
F
--------
I
T
F
V
H
K
A
N
V
L
T
G
D
K
-
F
F
R
R
I
V
R
E
V
----
A
G
E
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
---
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
D
Y
----------------------------------------------------------------------
109
PsiBlast_CBE
65.46
35%
-115
- C7 -
-
5HN5
2
?
A:
[3-277]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
-
Y
E
G
G
V
---
D
V
F
Q
---
E
C
G
S
-
P
I
R
E
E
D
L
E
E
I
R
-
R
S
D
A
V
L
F
G
A
T
T
T
P
F
D
L
P
G
Y
R
S
L
-------
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
-------------
I
I
P
D
L
-
R
-
T
-
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
----------
I
G
A
V
V
----
N
G
------
R
-
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
-----
G
S
F
--------
I
T
F
V
H
K
A
N
V
L
T
G
D
K
-
F
F
R
R
I
V
R
E
V
----
A
G
E
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
---
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
D
Y
----------------------------------------------------------------------
90
PsiBlast_CBE
64.78
37%
-64
- C7 -
-
4Y1P
1
?
B:
[5-312]
----
V
A
L
I
Q
G
D
G
I
G
P
E
V
V
S
K
S
K
T
I
L
A
R
L
N
E
K
F
S
L
P
I
E
Y
I
E
V
E
A
G
D
T
T
K
N
---
K
F
G
D
-
A
L
P
K
D
S
L
R
V
I
E
-
K
A
D
M
I
L
K
G
P
V
G
E
T
A
A
D
V
V
------------
V
K
L
R
L
M
Y
D
L
Y
A
N
L
R
P
A
K
S
L
P
G
L
E
N
K
--------
F
-
G
-
D
V
D
I
L
V
V
R
E
N
T
E
D
L
Y
K
G
L
E
H
------
V
I
---
S
----
D
G
----
V
T
V
-
G
I
K
--
V
I
T
R
A
A
S
T
R
I
A
Q
V
A
L
N
Q
A
L
R
R
-----
K
K
K
--------
V
V
C
V
H
K
S
N
V
M
R
I
T
D
G
L
F
A
E
S
C
R
N
V
L
K
--
G
K
---
V
E
Y
S
E
M
Y
V
D
A
A
A
A
N
L
V
R
N
P
Q
A
F
D
V
I
V
T
E
N
T
Y
G
D
I
L
S
D
E
A
G
Q
I
A
G
S
L
G
I
S
P
S
A
N
I
G
--
D
R
-
K
S
L
F
E
P
V
H
G
A
A
F
D
I
A
G
K
N
I
A
N
P
T
A
F
L
L
S
V
G
M
M
L
D
R
----
M
Q
E
L
S
GD
I
R
-
Y
N
N
A
A
K
S
L
R
D
A
I
Y
S
V
Y
S
E
G
-------------------------------------
104
PsiBlast_CBE
63.36
34%
-16
- C7 -
-
3TY4
7
LYS12_SCHPO
B:
[15-364]
------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
T
G
K
-
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
A
G
Y
S
-----
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
----
K
S
L
D
G
A
K
G
K
P
--------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
------
M
V
Q
N
T
P
-----
G
----
K
R
V
-
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
LD
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
------
G
H
-
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
D
L
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---
107
PsiBlast_CBE
62.85
34%
-16
- C7 -
-
3TY3
4
LYS12_SCHPO
A:
[15-364]
------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
T
G
K
-
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
A
G
Y
S
-----
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
----
K
S
L
D
G
A
K
G
K
P
--------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
------
M
V
Q
N
T
P
-----
G
----
K
R
V
-
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
LD
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
------
G
H
-
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
D
L
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---
103
PsiBlast_CBE
62.53
35%
8
- C7 -
-
3FMX
1
TTUC_PSEPU
X:
[5-361]
-
S
F
R
I
A
A
I
P
G
D
G
I
G
L
E
V
L
P
E
G
I
R
V
L
E
A
A
A
L
K
H
G
L
A
L
--
E
F
D
T
F
E
W
A
S
C
D
YYL
Q
H
G
K
-
M
M
P
D
D
W
A
E
Q
L
K
-
Q
Y
D
A
I
Y
F
G
A
V
G
W
P
--
D
K
V
P
D
H
I
-
S
L
W
G
S
-
L
L
K
F
R
R
E
F
D
Q
Y
V
N
I
R
P
V
R
L
F
P
G
V
P
--
C
A
L
A
N
R
K
-
V
-
G
-
D
I
D
F
V
V
V
R
E
N
T
E
G
E
Y
--
S
S
L
------
G
G
I
M
F
E
----
N
T
----
E
N
E
I
V
I
Q
E
S
I
F
T
R
R
G
V
D
R
I
L
K
Y
A
F
D
L
A
E
K
R
-----
E
R
K
H-------
V
T
S
A
T
K
S
N
G
M
A
I
S
M
-
P
Y
W
D
K
R
T
E
A
M
A
--
A
H
Y
P
H
V
S
W
D
K
Q
H
I
D
I
L
C
A
R
F
V
L
Q
P
E
R
F
D
V
V
V
A
S
N
L
F
G
D
I
L
S
D
L
G
P
A
C
A
G
T
I
G
I
A
P
S
A
N
L
N
PE
R
N
F
P
S
L
F
E
P
V
H
G
S
A
P
D
I
F
G
K
N
I
A
N
P
I
A
M
I
W
S
G
A
L
M
L
E
F
LGQG
D
------
E
R
-
Y
Q
R
A
H
D
D
M
L
N
A
I
E
R
V
I
A
D
G
-
S
V
T
P
D
M
-----
G
G
--
T
-
L
S
--
T
Q
Q
V
G
A
A
I
S
D
T
L
A
--
105
PsiBlast_CBE
62.48
34%
-16
- C7 -
-
3TY4
5
LYS12_SCHPO
A:
[15-364]
------
L
I
P
A
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
E
---
R
T
G
K
-
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
A
G
Y
S
-----
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
----
K
S
L
D
G
A
K
G
K
P
--------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
R
------
M
V
Q
N
T
P
-----
G
----
K
R
V
-
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
YSIHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
LD
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
--
D
N
F
V
-
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
E
F
----
M
------
G
H
-
Q
D
A
A
A
D
-
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
D
L
G
--
G
------
K
S
G
--
T
N
E
I
T
D
A
V
L
A
N
I
---