@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPF8: (2017-11-21 )
MKRIARIAVATYMGLAVNMGLAVNAVQAATTFLNVSYDPTREFYQEYNQAFGKFWKQRTGQDVDFKQSHGGSGKQARAVATGLEADVVTLALANDIDEIVKAGFIQPNWQKEFPNNSAPYTSTVVFLVRKGNPKNIRDWNDLTKPGVEIITPNPKTGGAPRWIYLSAWGYALKQPGGNDAKAKELVKKLYHNVNVLDLGARGSLTTFAERGIGDVLLSWENEALLATKGLDKDKYEIVYPSISILAEPSVAIVDKTVDKDGNRTLAKGYLNFLYSPLGQELAAKHYFRPRNPQVAAKYAAQFPKIKLFTINDVFGGWAKAQKTHFANGAIFDQIYDGKQ
Atome Classification :
(20 SA)
.........10........20..----.......30.........-40---.---.-...-....50........60-..-.......70.-.......80--.---.-.......90........100.....---.--.----.----110-..-----.--------.-------------..-...120..----.....130..------..-.-----..140....-.--.-----.150.....--.--..160.......170-------......------.---.---.180.......190.----------..-....200........210.......220..--------------.-...--------.230.--......240----.-----.-..--....250....----....260.......270.......280..-...--..-------290..------..--.--.--.----300---.--.-..-..------.310.........320.......330-.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
R
I
A
R
I
A
V
A
T
Y
M
G
L
A
V
NM
G
-
L
A
----
V
N
A
V
Q
A
A
T
-
T
F
L
NVSYD
P
-
T
----
R
---
E
-
F
Y
Q
-
E
Y
N
Q
A
F
G
K
F
W
K
QRTG--QD-VDFKQSHGGS-GK
Q
A
R
A
V
A---T---G-LEA
D
V
V
T
L
A
L
A
N
D
I
D
E
I
V
-KAGFIQ---P--N----
W
----
Q
---KE-----F--------P-------------NN-SAPY
T
S
T
V
----
V
F
L
V
RKGNPK------NI-R-----DWNDLTKPG-
V
--
E
-----
I
IT-PNPKT--G--GAP
R
W
I
Y
LSAWG
Y
---------
A
LKQPG------G---N---
D
A
K
A
K
E
L
V
K
K
L
YHNV----------
N
V
-
L
D
LGA-RGS
L
T
T
F
A
ERGI
G
D
V
L
L
SWEN
E
A
L
--------------
L
-ATK--------GLDKD--
K
Y
E
I
V
YP
S
-----
I
-----
S
-
I
L--AEP
S
V
-
A
I
V
D
K
----TVDKDGN
R
T
L
A
K
G
Y
L
N
F
L
Y
S
P
L
G
Q
E
L
A
A
K
-HYF--RP-------RN
P
Q
V
------
A
A
--
K
--
Y
--
A
----AQF---P--
K
-
I
K
-
L
F
------
T
I--NDVFG
G
W
A
K
A
Q
KTHFANG
A
I
F
D
-
Q
IYDGKQ
1
PsiBlast_PDB
85.26
64%
-68
- C2 -
-
1SBP
-
SUBI_SALTY
A:
[5-307]
-------------------------------------
L
L
N
V
S
Y
D
P
-
T
----
R
---
E
-
L
Y
E
-
Q
Y
N
K
A
F
S
A
H
W
K
Q
E
T
G
--
D
N
-
V
V
I
D
Q
S
H
G
G
S
-
G
K
Q
A
T
S
V
I
---
N
---
G
-
I
E
A
D
T
V
T
L
A
L
A
Y
D
V
N
A
I
A
-
E
R
G
R
I
D
---
K
--
N
----
W
----
I
---
K
R
-----
L
--------
P
-------------
D
D
-
S
A
P
Y
T
S
T
I
----
V
F
L
V
R
K
G
N
P
K
------
Q
I
-
H
-----
D
W
N
D
L
I
K
P
G
-
V
--
S
-----
V
I
T
-
P
N
P
K
S
--
S
--
G
G
A
R
W
N
Y
L
A
A
W
G
Y
---------
A
L
H
H
N
N
------
N
---
D
---
Q
A
K
A
E
D
F
V
K
A
L
F
K
N
V
----------
E
V
-
L
D
S
G
A
-
R
G
S
T
N
T
F
V
E
R
G
I
G
D
V
L
I
A
W
E
N
E
A
L
--------------
L
-
A
T
N
--------
E
L
G
K
D
--
K
F
E
I
V
T
P
S
-----
E
-----
S
-
I
L
--
A
E
P
T
V
-
S
V
V
D
K
----
V
V
E
K
K
D
T
K
A
V
A
E
A
Y
L
K
Y
L
Y
S
P
E
G
Q
E
I
A
A
K
-
N
F
Y
--
R
P
-------
R
D
A
D
V
------
A
K
--
K
--
Y
--
D
----
D
A
F
---
P
--
K
-
L
K
-
L
F
------
T
I
--
D
E
V
F
G
G
W
A
K
A
Q
K
D
H
F
A
D
G
G
T
F
D
-
Q
I
-----
2
PsiBlast_PDB
78.86
59%
40
- C2 -
-
5UM2
1
?
A:
[19-334]
------------------------------
S
H
R
E
I
-
G
L
L
N
V
S
Y
D
P
-
T
----
R
---
E
-
F
Y
R
-
D
Y
N
A
A
F
A
A
Q
W
K
Q
Q
H
P
--
Q
D
T
V
T
V
E
T
S
H
G
G
S
-
G
K
Q
A
R
A
V
I
---
D
---
G
-
I
E
A
D
V
V
T
L
A
L
A
Y
D
V
D
A
I
A
Q
K
A
K
L
I
E
---
T
--
D
----
W
----
E
---
K
R
-----
L
--------
P
-------------
D
N
-
S
A
P
Y
T
S
T
I
----
V
F
L
V
R
K
G
N
P
K
------
N
I
-
H
-----
D
W
P
D
L
L
R
S
G
-
V
--
A
-----
V
V
T
-
P
N
P
K
T
--
S
--
G
G
A
R
W
N
Y
L
A
A
W
A
Y
---------
A
D
H
I
F
K
------
G
---
D
---
R
E
R
I
L
R
Y
M
Q
A
L
F
R
N
V
----------
P
V
-
L
D
T
G
A
-
R
G
A
T
T
T
F
V
Q
R
G
I
G
D
V
L
L
A
W
E
N
E
A
L
--------------
L
-
A
R
E
--------
E
L
G
K
D
--
K
F
E
I
V
V
P
K
-----
L
-----
S
-
I
L
--
A
E
P
S
V
-
A
L
V
D
K
----
N
V
D
K
H
G
T
R
E
V
A
E
A
Y
L
R
Y
L
Y
A
P
E
G
Q
K
L
A
A
K
-
H
F
Y
--
R
P
-------
R
H
P
E
F
------
A
D
--
P
--
A
D
-
I
----
A
R
F
---
P
--
E
-
I
K
-
L
V
------
T
I
--
Q
Q
A
F
G
S
W
E
K
A
Q
Q
E
H
F
A
D
G
G
V
F
D
-
Q
I
Q
A
N
K
-
28
HHSearch
76.04
55%
24
- C2 -
-
5UM2
1
?
A:
[19-334]
------------------------------
S
H
R
E
I
-
G
L
L
N
V
S
Y
D
P
-
T
R
E
F
Y
R
---
D
-
Y
N
A
-
A
F
A
A
Q
W
K
Q
Q
H
---
P
Q
D
T
V
T
-
V
E
T
S
H
--
G
G
S
-
G
K
Q
A
R
A
V
I
---
D
---
G
-
I
E
A
D
V
V
T
L
A
L
A
Y
D
V
D
A
I
A
-
Q
K
A
K
L
I
---
E
T-
D
----
W
----
E
---
K
R
-----
L
--------
P
D------------
N
S
-
A
P
-
Y
T
S
T
I
----
V
F
L
V
R
K
G
N
P
K
------
N
I
-
H
-----
D
W
P
D
L
L
R
S
G
-
V
--
A
-----
V
V
T
-
P
N
P
K
T
--
S
--
G
G
A
R
W
N
Y
L
A
A
W
A
Y
---------
A
D
H
I
F
K
------
G
---
D
---
R
E
R
I
L
R
Y
M
Q
A
L
F
R
N
V
----------
P
V
-
L
D
T
G
A
-
R
G
A
T
T
T
F
V
Q
R
G
I
G
D
V
L
L
A
W
E
N
E
A
L
--------------
L
-
A
R
E
--------
E
L
G
K
D
--
K
F
E
I
V
V
P
K
-----
L
-----
S
-
I
L
--
A
E
P
S
V
-
A
L
V
D
K
N
V
D
K
H
----
G
T
R
E
V
A
E
A
Y
L
R
Y
L
Y
A
P
E
G
Q
K
L
A
A
K
-
H
F
Y
--
R
P
-------
R
H
P
E
F
------
A
D
P
-
A
--
D
--
I
----
A
R
F
---
P
--
E
-
I
K
-
L
V
------
T
I
--
Q
Q
A
F
G
S
W
E
K
A
Q
Q
E
H
F
A
D
G
G
V
F
D
-
Q
I
Q
A
N
K
-
29
HHSearch
72.42
58%
45
- C2 -
-
1SBP
-
SUBI_SALTY
A:
[2-308]
---------------------------------
D
I
-
Q
L
L
N
V
S
Y
D
P
-
T
R
E
L
Y
E
---
Q
-
Y
N
K
-
A
F
S
A
H
W
K
Q
E
----
T
G
--
D
N
-
V
V
I
D
Q
S
H
G
G
S
-
G
K
Q
A
T
S
V
I
---
N
---
G
-
I
E
A
D
T
V
T
L
A
L
A
Y
D
V
N
A
I
A
-
E
R
G
R
I
D
---
K
--
N
----
W
----
I
---
K
R
-----
L
--------
P
D------------
D
S
-
A
P
-
Y
T
S
T
I
----
V
F
L
V
R
K
G
N
P
K
------
Q
I
-
H
-----
D
W
N
D
L
I
K
P
G
-
V
--
S
-----
V
I
T
-
P
N
P
K
S
--
S
--
G
G
A
R
W
N
Y
L
A
A
W
G
Y
---------
A
L
H
H
N
N
------
N
---
D
---
Q
A
K
A
E
D
F
V
K
A
L
F
K
N
V
----------
E
V
-
L
D
S
G
A
R
G
-
S
T
N
T
F
V
E
R
G
I
G
D
V
L
I
A
W
E
N
E
A
L
--------------
L
-
A
T
N
--------
E
L
G
K
D
--
K
F
E
I
V
T
P
S
-----
E
-----
S
I
L
A
E
P
T
V
S
V
V
D
K
V
V
E
K
----
K
----
D
T
K
A
V
A
E
A
Y
L
K
Y
L
Y
S
P
E
G
Q
E
I
A
A
K
-
N
F
Y
--
R
P
-------
R
D
A
D
V
------
A
K
--
K
--
Y
--
D
----
D
A
F
---
P
--
K
-
L
K
-
L
F
------
T
I
--
D
E
V
F
G
G
W
A
K
A
Q
K
D
H
F
A
D
G
G
T
F
D
-
Q
I
S
----
27
Fugue
51.85
20%
0
- C2 -
-
4R6Y
1
PHNS_SALTY
A:
[1-317]
-
S
M
E
S
V
V
T
V
Y
S
I
D
G
L
---------------------------
H
D
G
-
D
----
N
---
S
-
W
Y
Q
-
V
Q
F
D
A
F
T
K
A
T
--------
G
-
I
T
V
R
Y
V
E
G
G
G
-
G
V
V
V
E
R
L
A
K
E
R
T
---
N
-
P
Q
A
D
V
L
V
T
A
P
P
-
F
I
Q
R
A
A
-
A
E
K
L
L
A
N
F
N
T
--
D
----
T
----
A
---
S
A
-----
I
--------
P
-------------
D
A
-
N
N
L
Y
S
P
L
V
K
N
Y
L
S
F
I
Y
N
S
K
L
L
K
------
T
A
P
A
-----
S
W
Q
D
L
L
D
G
K
-
F
--
K
NK---
L
Q
Y
-
S
T
P
G
Q
--
A
--
A
D
G
T
A
V
M
L
Q
A
F
H
S
---------
F
-----------
G
---
S
---
K
D
A
G
F
A
Y
L
G
K
L
Q
A
N
-----------
N
V
-
G
P
S
A
S
-
T
G
K
L
T
A
L
V
N
K
G
--
E
I
Y
V
A
N
G
D
L
Q
M
--------------
N
-
L
A
Q
--------
M
E
R
N
P
--
N
V
K
I
F
W
P
A
N
DKG
E
R
-----
S
-
A
L
--
A
I
P
Y
V
-
I
G
L
-------
V
Q
G
A
P
Q
S
E
N
G
K
K
L
I
N
F
L
L
S
K
E
A
Q
T
R
V
S
E
-
L
S
W
G-
M
P
-------
V
R
S
D
V
TPSD
E
H
Y
K
--
A
--
A
--
T
----
A
A
L
---
E
--
G
-
V
Q
-
S
W
------
Q
P
--
N
-----
W
D
D
V
A
V
S
L
S
A
D
I
S
R
W
H
-
K
V
T
E
S
--
35
HHSearch
45.72
17%
30
- C2 -
-
4R6Y
1
PHNS_SALTY
A:
[2-317]
--------------------------------
M
E
S
-
V
V
T
V
Y
S
I
D
G
-
L
HDGD
N
---
S
-
W
Y
Q
-
V
Q
F
D
A
F
T
K
A
----
T
G
--
I
T
-
V
R
Y
V
E
G
--
G
G
-
G
V
V
V
E
R
L
A
K
E
R
T
---
N
-
P
Q
A
D
V
L
V
T
A
P
P
-
F
I
Q
R
A
A
-
A
E
K
L
L
A
---
N
F
N
T
----
D
T---
A
---
S
A
-----
I
--------
P
DANN---------
L
Y
-
S
P
L
V
K
N
Y
L
----
S
F
I
Y
N
S
K
L
L
K
T-----
A
P
-
A
-----
S
W
Q
D
L
L
D
G
K
-
F
KN
K
-----
L
Q
Y
-
S
T
P
G
Q
--
A
--
A
D
G
T
A
-
V
M
---
L
Q
---------
A
F
H
S
F
G
----------
S
---
K
D
A
G
F
A
Y
L
G
K
L
Q
A
N
N
----------
V
G
-
P
S
A
S
T
-
G
-
K
L
T
A
L
V
N
K
G
E
I
Y
V
A
N
G
D
L
Q
M
N
L
--------------
A
-
Q
M
E
--------
R
-
N
-
P
--
N
V
K
I
F
W
P
A
-----
N
DKG
E
R
S
A
L
A
--
I
P
Y
V
I
-
G
L
V
Q
G
----
A
----
P
Q
S
E
N
G
K
K
L
I
N
F
L
L
S
K
E
A
Q
T
R
V
S
E
L
S
W
G
--
M
P
-------
V
R
S
D
V
------
T
P
SD
E
--
H
--
Y
----
K
A
A
T
A
-
A
L
E
G
-
V
Q
-
S
W
Q
P
N
W
D
-
D
V
--
A
V
S
L
S
A
D
I
S
R
W
H
K
V
T
E
S
-------------
40
HHSearch
45.65
21%
24
* C2 *
-
4R75
5
?
A:
[3-319]
---------------------------------
K
G
-
R
L
V
I
Y
C
S
A
T
-
N
--------
V
-
M
C
E
-
N
A
A
K
T
F
E
Q
K
----
Y
D
--
V
K
-
T
S
F
I
R
N
--
G
S
-
G
S
T
F
A
K
I
E
A
E
K
N
---
N
-
P
Q
A
D
V
W
Y
G
G
T
L
D
P
Q
S
Q
A
G
-
E
L
G
L
L
E
---
A
--
Y
R
S
PN
I
----
D
QIM
P
K
-----
F
QDPAKVKG
N
-------------
L
S
-
S
A
V
Y
I
G
I
L
----
G
F
A
V
N
T
E
R
L
K
K
L
GIEK
I
P
-
Q
-----
C
W
N
D
L
T
D
P
K
-
L
KG
E
-----
I
Q
I
-
A
D
P
Q
S
--
S
--
G
T
A
Y
-
T
A
I
---
A
T
---------
F
A
Q
L
W
G
--------------
E
D
K
A
F
D
Y
F
K
H
L
H
P
N
I
----------
S
Q
-
Y
T
K
S
G
-
I
-
T
P
A
R
N
A
A
R
G
E
T
T
V
G
I
G
F
L
H
D
Y
A
--------------
L
-
E
K
E
--------
Q
-
G
-
A
--
P
L
E
M
V
V
P
C
-----
E
-----
G
T
G
Y
--
E
L
G
G
V
-
S
I
L
K
G
----
A
----
R
N
L
D
N
A
K
L
F
V
D
F
A
L
S
K
E
G
Q
E
T
A
W
K
K
G
Q
A
LQ
T
L
-------
T
N
T
T
A
------
E
Q
S-
P
--
L
--
A
----
F
D
L
---
T
--
K
-
L
K
-
L
I
DYDFE-
K
Y
GA
S
D
E
R
K
R
L
I
N
K
W
V
D
E
I
K
L
-------------
41
HHSearch
45.10
21%
28
- C2 -
-
4R73
4
?
A:
[2-319]
--------------------------------
S
K
G
-
R
L
V
I
Y
C
S
A
T
-
N
--------
V
-
M
C
E
-
N
A
A
K
T
F
E
Q
K
----
Y
D
--
V
K
-
T
S
F
I
R
N
--
G
S
-
G
S
T
F
A
K
I
E
A
E
K
N
---
N
-
P
Q
A
D
V
W
Y
G
G
T
L
D
P
Q
S
Q
A
G
-
E
L
G
L
L
E
---
A
--
Y
R
S
PN
I
----
D
QIM
P
K
-----
F
QDPAKVKG
N
-------------
L
S
-
S
A
V
Y
I
G
I
L
----
G
F
A
V
N
T
E
R
L
K
K
L
GIEK
I
P
-
Q
-----
C
W
N
D
L
T
D
P
K
-
L
KG
E
-----
I
Q
I
-
A
D
P
Q
S
--
S
--
G
T
A
Y
-
T
A
I
---
A
T
---------
F
A
Q
L
W
G
--------------
E
D
K
A
F
D
Y
F
K
H
L
H
P
N
I
----------
S
Q
-
Y
T
K
S
G
-
I
-
T
P
A
R
N
A
A
R
G
E
T
T
V
G
I
G
F
L
H
D
Y
A
--------------
L
-
E
K
E
--------
Q
-
G
-
A
--
P
L
E
M
V
V
P
C
-----
E
-----
G
T
G
Y
--
E
L
G
G
V
-
S
I
L
K
G
----
A
----
R
N
L
D
N
A
K
L
F
V
D
F
A
L
S
K
E
G
Q
E
T
A
W
K
K
G
Q
A
LQ
T
L
-------
T
N
T
T
A
------
E
Q
S-
P
--
L
--
A
----
F
D
L
---
T
--
K
-
L
K
-
L
I
DYDFE-
K
Y
GA
S
D
E
R
K
R
L
I
N
K
W
V
D
E
I
K
L
-------------
38
HHSearch
44.20
15%
23
- C2 -
-
3PU5
1
?
A:
[4-324]
--------------------------------
A
D
D
-
H
I
Y
V
T
S
S
G
G
-
S
F
L
--
E
---
N
-
V
R
K
-
H
M
A
E
P
F
E
K
Q
----
S
G
--
V
K
-
V
T
L
V
P
G
--
T
N
-
P
A
H
A
L
K
I
L
S
SR
G
---
T
-
P
P
Y
D
V
A
A
F
G
G
N
-
D
M
Y
R
L
I
-
R
A
K
K
L
A
---
Q
V
D
E
----
K
SVPS
L
---
A
D
-----
V
--------
P
EKFKADWEG----
C
G
-
S
L
Y
D
Y
S
S
V
----
G
I
A
Y
R
P
D
K
I
Q
G-----
G
V
-
K
-----
S
W
K
E
F
V
E
R
T
-
V
--
A
GEFGK
Q
V
F
F
N
N
L
S
S
--
N
--
V
R
G
A
-
E
V
L
---
S
M
---------
F
G
K
I
Y
G
------
S
GYG
D
---
I
E
A
S
I
A
T
L
E
R
M
K
P
H
I
----------
F
K
-
F
F
T
A
F
-
N
-
D
P
V
V
L
L
T
S
G
E
G
A
I
G
P
G
W
D
G
R
T
F
--------------
I
-
A
E
D
--------
S
T
K
-
G
--
M
V
K
W
V
D
P
T
-----
E
-----
G
A
V
S
--
S
G
P
V
M
-
A
V
V
K
G
----
G
----
K
-
E
D
L
A
K
A
F
M
N
Y
A
L
G
E
E
A
Q
K
A
F
C
E
A
M
Y
Y
--
G
A
-------
V
N
R
K
V
------
Q
Y
--
S
EK
L
--
K
----
H
R
L
---
P
--
S
-
I
D
-
S
V
Q
L
V
D
T
A
L
L
--
I
K
N
M
S
A
L
L
D
L
W
N
K
R
I
A
--------------
23
Fugue
43.31
23%
54
- C2 -
-
5T1P
2
?
A:
[22-347]
-
I
D
E
N
L
I
K
A
A
Q
A
E
G
R
V
N
S
L
A
M
P
D
----
T
W
A
N
W
K
D
T
W
A
D
L
K
N
L
Y
D
I
-
E
----
H
---
S
-
D
T
D
M
S
S
A
Q
E
I
A
K
F
K
T
E
K
K
N
--
A
S
-
G
D
--
I
G
D
V
G
A
-
S
F
G
E
I
A
V
K
---
Q
---
G
-----
V
A
Q
P
F
K
T
S
Y
W
D
Q
I
-----------
P
--
T
----
W
----
A
---
K
D
-----
K
--------
D
-------------
G
N
W
L
L
A
Y
T
G
T
I
----
A
F
I
V
N
K
D
V
V
K
------
D
I
P
K
-----
T
W
Q
D
L
L
K
G
N
-
Y
--
K
-----
I
T
V
-
G
D
V
S
V
--
A
---
A
Q
A
V
S
A
V
L
A
A
N
Y
---------
A
L
G
G
D
E
------
K
---
D
---
L
S
P
A
L
A
F
F
N
T
L
A
K
Q
G
----------
R
L
-
V
N
N
D
V
-
S
---
I
A
N
L
E
K
G
E
V
E
V
G
L
V
W
D
F
N
G
L
--------------
G
-
Y
R
D
--------
K
V
G
K
D
--
R
Y
E
V
L
I
P
A
-----
D
-----
G
-
S
V
--
I
S
G
Y
T
-
T
I
I
N
K
----
Y
A
K
---
H
P
N
A
A
K
L
A
R
E
F
I
L
S
D
K
G
Q
I
N
L
A
K
-
G
Y
A
--
R
P
IRIDH
I
T
L
P
D
D
I
------
K
A
--
K
--
L
LP
S
----
E
Q
Y
---
K
--
N
-
A
R
-
A
I
------
K
D
--
Q
K
A
W
E
K
S
A
K
E
L
P
Q
L
W
Q
E
K
V
I
V
D
M
K
------
44
HHSearch
42.69
17%
-4
- C2 -
-
2OWT
-
?
A:
[5-319]
---------------------------------
S
D
-
E
V
S
L
Y
T
T
R
E
-
P
--------
K
-
L
I
Q
-
P
L
L
D
A
F
A
K
D
----
S
G
--
I
K
-
V
N
T
V
F
V
--
K
D
--
G
L
L
E
R
V
R
A
E
G
D
---
K
-
S
P
A
D
V
L
M
T
V
D
I
G
N
L
I
D
L
V
-
N
G
G
V
T
Q
---
K
I
Q
S
----
Q
T
---
L
---
D
S
V
VPAN
L
RGAE----
G
-------------
S
W
-
Y
A
L
S
L
R
D
R
----
V
L
Y
V
E
K
D
L
K
L
------
D
S
-
F
-----
R
Y
G
D
L
A
D
P
K
-
W
KG
K
-----
V
C
I
-
R
S
G
Q
---
H
--
P
Y
N
T
-
A
L
V
---
A
A
---------
M
I
A
H
D
G
--------------
A
E
A
T
E
K
W
L
R
G
V
K
A
N
L
----------
A
R
K
A
A
G
G
D
-
R
-
D
V
A
R
D
I
L
G
G
I
C
D
I
G
L
A
N
A
Y
Y
V
G
--------------
H
-
M
K
N
AEPGT
D
A
R
K
W
G
-
D
--
A
I
K
V
V
R
P
T
F
A---
G
-----
G
T
H
V
--
N
I
S
G
A
-
A
V
A
A
H
----
A
----
P
N
K
A
N
A
V
K
L
L
E
Y
L
V
S
E
P
A
Q
T
L
Y
A
Q
A
N
Y
E
--
Y
P
-------
V
R
A
G
V
------
K
L
--
D
A
-
V
--
V
----
A
S
F
G
--
P
--
L
K
V
D
-
T
L
P
V
A
---
E
I
--
A
K
Y
R
K
Q
A
S
E
L
V
D
K
V
----------------
31
HHSearch
40.86
20%
47
- C2 -
-
5T1P
1
?
D:
[20-300]
-------------------
Q
-
A
I
DENL
I
K
A
A
Q
A
E
G
-
R
V
N
S
L
A
M
P
D
-
T
----
W
---
A
-
N
W
K
-
D
T
W
A
D
L
K
N
L
----
Y
D
--
I
E
-
H
S
D
T
D
M
--
S
S
-
A
Q
E
I
A
K
F
K
---
T
EKK
N
-
A
S
G
D
I
G
D
V
G
A
S
-
F
G
E
I
A
V
-
K
Q
G
V
A
Q
---
P
FK
T
----
S
Y---
W
---
D
Q
-----
I
--------
P
TWAKDKDGN----
W
L
-
L
A
Y
T
-
G
T
I
----
A
F
I
V
N
K
D
V
V
K
D-----
I
P
-
K
-----
T
W
Q
D
L
L
K
G
N
-
Y
--
K
-----
I
T
V
-
G
D
V
S
V
--
A
--
A
Q
A
V
S
A
V
L
---
A
----------
A
N
Y
A
L
G
------
G
---
D
EKD
L
S
P
A
L
A
F
F
N
T
L
A
K
Q
G
----------
R
L
-
V
N
-
N
--
D
-
V
S
I
A
N
L
E
K
G
E
V
E
V
G
L
V
W
D
F
N
G
L
--------------
G
-
Y
R
D
--------
K
V
G
K
D
--
R
Y
E
V
L
I
P
A
-----
D
-----
G
S
V
I
--
S
G
Y
T
T
-
I
I
N
K
Y
----
A
----
K
H
P
N
A
A
K
L
A
R
E
F
I
L
S
D
K
G
Q
I
N
L
A
K
-
G
Y
A
--
R
P
-------
I
R
I
D
H
------
I
----------------------------------------------------------------------
36
HHSearch
40.47
16%
45
- C2 -
-
2QRY
1
THIB_ECOLI
D:
[21-329]
--------------------------------
M
K
P
-
V
L
T
V
Y
T
Y
D
S
-
F
----
A
ADW
G
-
P
G
P
-
V
V
K
K
A
F
E
A
D
----
C
N
--
C
E
-
L
K
L
V
A
L
--
E
D
G
V
S
L
L
N
R
L
R
MEG
K
---
N
-
S
K
A
D
V
V
L
G
L
D
N
N
L
L
D
A
A
S
-
K
T
G
L
F
A
---
K
SG
V
----
A
----
A
DA-
V
N
-----
V
--------
P
GGWNND-------
T
F
-
V
P
F
D
Y
G
Y
F
----
A
F
V
Y
D
K
N
K
L
K
N-----
P
P
-
Q
-----
S
L
K
E
L
V
E
S
D
-
Q
NW
R
-----
V
I
Y
-
Q
D
P
R
T
--
S
--
T
P
G
L
-
G
L
L
---
L
W
---------
M
Q
K
V
Y
G
---------------
D
D
A
P
Q
A
W
Q
K
L
A
K
K
T
----------
V
T
-
V
T
K
G
W
-
S
-
E
A
Y
G
L
F
L
K
G
E
S
D
L
V
L
S
Y
T
T
S
P
A
--------------
Y
H
I
L
E
--------
E
K
K
-
D
--
N
Y
A
A
A
N
F
S
-----
E
-----
G
H
Y
L
--
Q
V
E
V
A
-
A
R
T
A
A
----
S
----
K
Q
P
E
L
A
Q
K
F
L
Q
F
M
V
S
P
A
F
Q
N
A
I
P
T
G
N
W
M
--
Y
P
-------
V
A
N
V
T
------
L
P
--
A
--
G
--
F
----
E
K
L
T--
K
--
P
-
A
T
-
T
L
EFTPA-
E
V
--
A
A
Q
R
Q
A
W
I
S
E
W
Q
R
A
V
S
--------------
42
HHSearch
40.22
15%
41
- C2 -
-
5L9G
7
?
A:
[21-344]
----------------------------------
M
-
D
V
V
I
A
S
S
G
G
G
W
----
Q
---
E
A
Q
D
K
-
A
L
W
A
P
A
A
K
A
----
L
N
--
I
T
-
Y
T
Q
D
T
F
Q
-
N
W
-
A
E
A
R
A
Q
V
E
---
S
---
G
S
V
T
W
D
I
I
Q
I
G
I
A
-
D
E
P
Q
A
K
-
A
A
G
V
L
E
---
K
LD
P
----
D
----
I
VNK
A
D
-----
F
--------
P
PGSVTD-------
S
F
-
V
A
N
S
N
Y
S
T
----
L
I
A
W
N
K
K
T
Y
G
DN----
G
P
-
K
-----
S
M
A
D
F
F
D
V
K
K
F
P
G
K
-----
R
A
L
-
W
N
Q
P
I
--
G
----
M
I
E
A
A
A
L
A
L
G
T
---------
P
R
D
K
V
Y
E
F
L
ST
E
E
---
G
---
R
K
A
A
I
A
K
L
T
E
L
A
P
S
V
----------
S
V
-
W
W
E
S
G
-
A
-
Q
A
A
Q
L
I
K
D
G
E
V
D
M
I
I
T
W
G
G
R
V
Q
--------------
G
-
A
I
N
--------
D
-
G
-
A
--
N
F
A
Y
T
F
N
------
D
-----
A
-
Q
L
--
G
T
D
G
Y
-
A
I
V
K
G
----
A
----
P
H
R
D
A
A
M
R
F
L
K
E
M
S
K
A
E
Y
Q
K
D
L
P
N
S
F
A
T
--
A
P
-------
A
N
M
K
A
------
Y
D
L
A
K
--
Y
--
T
P
E
K
M
A
T
M
ASA
P
--
E
N
V
A
V
Q
Y
S
V
D
P
N
-
F
W
--
A
K
H
A
K
W
A
S
E
A
Y
D
N
V
R
L
S
-------------
43
HHSearch
38.65
15%
43
- C2 -
-
5L9P
-
?
B:
[15-343]
----------------------------
V
P
R
G
S
H
M
-
D
V
V
I
A
S
S
G
G
G
W
----
Q
---
E
A
Q
D
K
-
A
L
W
A
P
A
A
K
A
----
L
N
--
I
T
-
Y
T
Q
D
T
F
Q
-
N
W
-
A
E
A
R
A
Q
V
E
---
S
---
G
S
V
T
W
D
I
I
Q
I
G
I
A
-
D
E
P
Q
A
K
-
A
A
G
V
L
E
---
K
LD
P
----
D
----
I
VNK
A
D
-----
F
--------
P
PGSVTD-------
S
F
-
V
A
N
S
N
Y
S
T
----
L
I
A
W
N
K
K
T
Y
G
DN----
G
P
-
K
-----
S
M
A
D
F
F
D
V
K
K
F
P
G
K
-----
R
A
L
-
W
N
Q
P
I
--
G
----
M
I
E
A
A
A
L
A
L
G
T
---------
P
R
D
K
V
Y
E
F
L
ST
E
E
---
G
---
R
K
A
A
I
A
K
L
T
E
L
A
P
S
V
----------
S
V
-
W
W
E
S
G
-
A
-
Q
A
A
Q
L
I
K
D
G
E
V
D
M
I
I
T
W
G
G
R
V
Q
--------------
G
-
A
I
N
--------
D
-
G
-
A
--
N
F
A
Y
T
F
N
------
D
-----
A
-
Q
L
--
G
T
D
G
Y
-
A
I
V
K
G
----
A
----
P
H
R
D
A
A
M
R
F
L
K
E
M
S
K
A
E
Y
Q
K
D
L
P
N
S
F
A
T
--
A
P
-------
A
N
M
K
A
------
Y
D
L
A
K
--
Y
--
T
P
E
K
M
A
T
M
ASA
P
--
E
N
V
A
V
Q
Y
S
V
D
P
N
-
F
W
--
A
K
H
A
K
W
A
S
E
A
Y
D
N
V
R
L
--------------
37
HHSearch
38.61
16%
42
- C2 -
-
2QRY
1
THIB_ECOLI
C:
[16-329]
---------------------------
P
R
G
S
H
M
K
P
-
V
L
T
V
Y
T
Y
D
S
-
F
----
A
ADW
G
-
P
G
P
-
V
V
K
K
A
F
E
A
D
----
C
N
--
C
E
-
L
K
L
V
A
L
--
E
D
G
V
S
L
L
N
R
L
R
MEG
K
---
N
-
S
K
A
D
V
V
L
G
L
D
N
N
L
L
D
A
A
S
-
K
T
G
L
F
A
---
K
SG
V
----
A
----
A
DA-
V
N
-----
V
--------
P
GGWNND-------
T
F
-
V
P
F
D
Y
G
Y
F
----
A
F
V
Y
D
K
N
K
L
K
N-----
P
P
-
Q
-----
S
L
K
E
L
V
E
S
D
-
Q
NW
R
-----
V
I
Y
-
Q
D
P
R
T
--
S
--
T
P
G
L
-
G
L
L
---
L
W
---------
M
Q
K
V
Y
G
---------------
D
D
A
P
Q
A
W
Q
K
L
A
K
K
T
----------
V
T
-
V
T
K
G
W
-
S
-
E
A
Y
G
L
F
L
K
G
E
S
D
L
V
L
S
Y
T
T
S
P
A
--------------
Y
H
I
L
E
--------
E
K
K
-
D
--
N
Y
A
A
A
N
F
S
-----
E
-----
G
H
Y
L
--
Q
V
E
V
A
-
A
R
T
A
A
----
S
----
K
Q
P
E
L
A
Q
K
F
L
Q
F
M
V
S
P
A
F
Q
N
A
I
P
T
G
N
W
M
--
Y
P
-------
V
A
N
V
T
------
L
P
--
A
--
G
--
F
----
E
K
L
T--
K
--
P
-
A
T
-
T
L
EFTPA-
E
V
--
A
A
Q
R
Q
A
W
I
S
E
W
Q
R
A
V
S
--------------
46
HHSearch
38.28
17%
37
- C2 -
-
4GL0
8
?
A:
[10-285]
---------------------------------
S
N
-
T
L
T
I
Y
N
W
G
D
----------
Y
-
I
D
P
-
S
L
I
T
K
F
E
K
E
----
T
G
--
I
K
-
V
I
Y
Q
T
F
--
D
S
N
E
A
M
M
T
K
I
E
Q
--
G
---
G
-
T
T
F
D
I
A
V
P
S
D
Y
-
A
I
S
K
M
K
-
E
E
N
L
L
I
---
P
L
D
H
----
S
KLPN
E
---
K
Y
-----
L
--------
D
PRFMDLSFDDDNK
Y
S
-
M
P
Y
F
W
G
T
L
----
G
I
I
Y
N
K
E
M
F
P
DK----
N
F
-
D
-----
T
W
N
A
L
F
D
P
E
-
L
--
K
NQ---
I
L
L
-
I
D
G
A
R
--
E
--
V
M
G
L
--
G
L
N
S
L
G
Y
---------
S
L
N
D
T
N
K
-----
A
---
H
---
L
Q
A
A
R
D
K
L
E
T
M
T
P
N
V
----------
K
A
-
I
--
V
G
-
D
-
E
I
K
L
L
M
A
D
N
-
A
G
V
A
V
T
F
S
G
E
A
A
--------------
E
-
M
L
S
--------
E
-
N
-
E
--
D
L
E
Y
V
I
P
K
-----
D
-----
G
S
N
L
--
W
F
D
N
M
-
V
I
P
K
T
----
A
----
K
N
V
D
G
A
H
K
F
I
N
F
M
L
K
P
E
N
A
A
I
N
A
E
Y
V
G
Y
--
A
T
-------
P
N
A
K
A
------
V
E
---------------------------------------------------------------------
20
Fugue
37.70
17%
14
- C2 -
-
2ONS
-
WTPA_ARCFU
A:
[1-314]
------------------------------
G
H
M
N
V
-
K
L
K
V
F
H
A
G
S
-
L
----
T
---
E
-
P
M
K
-
A
F
K
R
A
F
E
E
K
-----
H
--
P
N
-
V
E
V
Q
T
E
A
A
G
S
-
A
A
T
I
R
K
V
T
---
E
L--
G
-
R
K
A
D
V
I
A
T
A
D
Y
T
L
I
Q
K
M
M
-
Y
P
E
F
A
-------
N
----
W
----
T
---
I
M
-----
F
--------
A
-------------
K
N
-
Q
------
I
----
V
L
A
Y
R
N
D
S
R
Y
------
A
D
-
E
INSQN
W
Y
E
I
L
K
R
P
D
-
V
--
R
-----
F
G
F
-
S
N
P
N
D
D
P
C
--
G
Y
R
S
L
M
A
I
Q
L
A
E
L
Y
Y
NDPT
I
F
D
E
L
V
A
K
N
------
S
---
N
---
L
R
F
S
E
D
N
G
S
Y
V
L
R
M
P
SSERIEINKS
K
I
-
M
I
R
S
M
-
E
M
E
L
I
H
L
V
E
S
G
E
L
D
Y
F
F
I
Y
K
S
V
A
K
Q
H
G
F
N
F
V
E
L
P
VEID
L
-
S
S
P
--------
D
Y
A
E
L
Y
S
K
V
K
V
V
L
A
N
-----
G
-----
K
-
E
V
--
T
G
K
P
I
-
V
Y
G
I
T
----
I
P
K
N
A
E
N
R
E
L
A
V
E
F
V
K
L
V
I
S
E
E
G
Q
E
I
L
R
E
-
L
G
Q
--
E
P
-------
L
V
P
P
R
------
A
D
--
T
--
A
--
V
----
P
S
L
---
K
--
A
----
M
V
------
E
V
--
S
-----------------------------
39
HHSearch
37.47
15%
2
- C2 -
-
3FJM
-
?
B:
[21-251]
------------------------------------
D
V
N
L
Y
G
P
G
G
-
P
----
H
---
T
-
A
L
K
-
D
I
A
N
K
Y
S
E
K
----
T
G
--
V
K
-
V
N
V
N
F
G
--
P
Q
-
A
T
W
F
E
K
A
K
---------
K
D
A
D
I
L
F
G
A
S
D
Q
S
-
A
L
A
I
-
A
S
D
F
G
K
---
D
-------
F
----
N
---
V
---------------
S
-------------
K
I
-
K
P
L
Y
F
R
E
A
----
I
I
L
T
Q
K
G
N
P
L
------
K
I
-
K
-----
G
L
K
D
L
A
N
K
K
-
V
--
R
-----
I
V
V
-
P
E
G
A
G
--
K
SN
T
S
G
T
-
G
V
W
---
E
D
---------
M
---
I
G
--------------
R
T
Q
D
I
K
T
I
Q
N
F
R
N
N
I
----------
V
A
-
F
V
P
N
S
-
G
-
S
A
R
K
L
F
A
Q
D
Q
A
D
A
W
I
T
W
I
D
W
S
K
--------------
S
--------------
N
-
P
--
D
I
G
T
A
V
A
I
-----
E
-----
K
D
L
V
--
V
Y
R
T
F
-
N
V
I
A
K
----
E
----
G
A
S
K
E
T
Q
D
F
I
A
Y
L
S
S
K
E
A
K
E
I
F
K
K
-
Y
G
W
--
R
E
-------
H
---------------------------------------------------------------------------------
4
PsiBlast_PDB
37.46
46%
-152
- C1 -
-
4JB7
-
?
A:
[102-133]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
R
E
A
----
I
I
L
V
K
K
G
N
P
K
------
N
I
-
K
-----
G
M
A
D
L
L
K
P
G
-
I
--
G
-----
I
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------