@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPM7: (2017-11-22 )
MSADTQHFTGTDQYIATDSLKLAVKAARALQKPLLVKGEPGTGKTLLAEQVAESLGLKLITWHIKSTTKAQQGLYEYDAVSRLRDSQLGDDRVYDIKNYIKPGKLWEAFTSEERCVLLIDEIDKADIEFPNDLLHELDKMSFYVYETGETITATQRPIVIITSNNEKELPDAFLRRCFFHYIEFPDEATMREIISVHFPNISVTLVNEALQVFFKLREIPNLKKPPSTSELIDWLSLLMADDMPEDVLRNRDTSKAIPPLYGALIKNEQDVQLLERLAFMSRR
Atome Classification :
(21 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30---..-------......40........50....-....60........70........80........90.--.......100.......110.......120-----.-----------.-----...----.-----------.130-----..--------.....--..140..-......150.......160---........170....--.----..-.180-.---...--.....190.......200.......210.......--220.......230.......240.......250.......260.......270.......280.-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSADTQHFTGTD
Q
Y
IA
T
D
S
L
K
L
A
V
K
A
A
R
A
LQ---K
P
-------
L
L
VKGEPGT
G
K
T
L
L
A
E
Q
V
A
E
SL-G
L
K
L
I
T
W
H
IKST
T
K
A
QQG
L
Y
E
Y
D
A
V
S
R
L
R
DSQLGDD
R
--
V
Y
D
I
K
NYIKP
G
K
L
W
E
A
FTSEE
R
C
V
L
L
I
DEI-----D-----------K-----ADI----E-----------F
P
-------
N
D
--------
L
L
H
E
L
--
D
K
M
-
S
F
Y
-
V
Y
ETG
E
T
I
TATQR
P
I
V
I
I
----TSNNEKE
L
P
D
-
A
F
L
R
--
R
----
C
F
-
F
H
---
Y
---IEF--P
D
E
A
T
M
R
E
I
I
S
VHFPNI
S
V
T
L
V
N
E
A
L
Q
V
F
F
K
L
R
EI--PNLKKPP
S
T
S
E
L
I
D
W
L
S
L
L
M
ADDM
P
E
D
V
L
RNRDTSKAI
P
P
L
Y
G
A
L
IKN
E
Q
D
V
Q
L
L
E
R
L
A
F
MSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.08
24%
0
- C- -
-
5MPA
-
PRS10_YEAST
L:
[216-10]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
A
T
I
-
G
A
N
F
I
----------------
F
S
P
A
S
G
I
V
D
K
Y
I
G
E
S
-------
A
R
I
I
R
--
E
M
F
A
Y
A
K
E
H
E
P
C
I
I
F
M
D
E
V
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
T
Q
M
-
D
G
F
------
D
N
L
G
Q
T
K
---
I
I
M
----
A
T
N
R
P
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
---
R
K
V
E
I
P
L
--
P
N
E
A
G
R
L
E
I
F
K
I
H
T
A
K
V
K
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.08
24%
0
- C- -
-
5MP9
-
PRS10_YEAST (first)
L:
[216-10]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
A
T
I
-
G
A
N
F
I
----------------
F
S
P
A
S
G
I
V
D
K
Y
I
G
E
S
-------
A
R
I
I
R
--
E
M
F
A
Y
A
K
E
H
E
P
C
I
I
F
M
D
E
V
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
T
Q
M
-
D
G
F
------
D
N
L
G
Q
T
K
---
I
I
M
----
A
T
N
R
P
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
---
R
K
V
E
I
P
L
--
P
N
E
A
G
R
L
E
I
F
K
I
H
T
A
K
V
K
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
74.84
25%
0
- C- -
-
5MPA
-
I:
[215--40]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
---
K
G
-------
V
I
L
Y
G
A
P
G
T
G
K
T
L
L
A
K
A
V
A
N
Q
T
-
S
A
T
F
L
R
I
V
G
S
E
L
I
Q
K
Y
L
----------------
G
D
G
---
P
R
L
C
R
Q
------
I
F
K
V
A
G
E
N
A
P
S
I
V
F
I
D
E
I
-----
D
-----------
A
-----
I
G
T
----
K
RYDSNSGG
E
R
E
I
Q
-------
R
T
--------
M
L
E
L
L
--
N
Q
L
-
D
---------
G
F
D
D
R
G
D
V
K
V
I
M
----
A
T
N
K
I
E
T
L
D
P
-
A
L
I
R
PG
R
----
I
D
R
K
I
---
L
---
F
E
N
--
P
D
L
S
T
K
K
K
I
L
G
I
H
T
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Fugue
72.31
20%
29
- C2 -
-
3VKG
6
?
A:
[47-3244]
E
I
D
S
L
K
E
TAWSAIIPA
F
D
H
A
Q
N
L
I
K
I
Y
L
K
G
N
A
I
I
T
D
L
H
SEAIK
D
R
H
W
K
I
L
K
K
R
L
NTNWIITELT
L
G
S
I
W
D
S
DLARN
E
N
I
Y
R
E
V
I
T
A
A
Q
G
E
I
A
L
E
E
F
L
K
G
V
R
E
F
W
T
TLELD
L
V
N
Y
QRK
C
K
L
V
R
G
W
D
D
L
F
N
K
L
A
E
H
L
N
S
I
S
A
M
KMSPYYKVF
E
E
E
A
N
H
W
D
D
R
L
N
K
V
R
S
L
L
D
V
W
I
D
V
Q
R
R
W
V
Y
LEGIFINQLL
P
A
E
S
T
R
F
K
S
I
N
S
E
F
I
A
I
L
K
K
V
S
G
A
PL
I
L
E
V
L
A
IER
I
Q
Q
T
M
E
R
L
S
D
L
L
G
K
V
Q
K
A
L
G
E
Y
L
E
R
Q
R
S
A
F
A
R
F
Y
F
V
G
D
E
D
L
L
E
I
I
G
N
S
KDIIKIQKHFRKMFAGLA
N
L
T
L
D
DEKTTII
G
M
S
S
AEG
E
T
V
T
F
K
K
P
I
S
IANGPK
I
H
E
W
L
T
M
V
E
S
E
M
K
S
T
L
A
T
L
L
S
E
S
L
Q
H
F
N
Q
VDVNDHS
K
Y
S
E
W
V
D
N
Y
P
T
Q
L
V
L
L
T
S
Q
I
V
W
S
T
Q
V
D
Q
A
L
GGGTLQ
Q
S
K
I
Q
E
Q
L
Q
S
I
E
Q
T
T
Q
M
I
L
N
N
L
A
D
S
VLQDLS
A
Q
K
R
K
K
F
E
H
L
I
T
E
L
V
H
Q
R
D
V
V
R
Q
L
Q
K
CKNLTGNKDF
D
W
L
Y
H
M
R
Y
Y
Y
D
ATQENVLHK
L
V
I
H
M
AN
A
T
F
Y
YGFEYLGIGERLVQT
P
L
T
D
R
C
Y
L
T
L
T
Q
A
L
E
S
R
M
G
G
N
P
F
G
P
A
GTG
K
T
E
T
V
K
A
L
G
S
Q
L
G
R
F
V
L
V
F
C
CDEGFD
L
Q
A
M
S
R
I
F
V
G
L
C
Q
C
G
A
W
G
C
F
D
EFNRLE
E
R
I
L
S
A
V
S
Q
Q
I
Q
T
I
Q
V
A
L
K
E
NSKEVELLN
I
S
L
H
QD
M
G
I
F
V
T
M
N
P
GYAGRSNLPDNLKKL
F
R
S
M
A
M
IKPD
R
E
M
I
A
Q
V
M
L
Y
S
Q
GFKT
A
E
V
L
A
G
K
I
V
P
L
F
K
L
C
Q
E
QLSAQSHYDFG
L
R
A
L
K
S
V
L
V
S
A
G
G
I
K
R
K
CQPPD
A
E
S
K
T
K
A
D
Q
I
Y
C
Q
Y
E
I
G
V
L
L
N
S
I
N
D
TMIPKLVADD
I
P
L
I
Q
S
L
L
L
D
V
F
PG
S
Q
L
Q
P
I
QM
D
Q
L
R
K
K
I
Q
E
I
A
K
Q
R
HLVTK
Q
E
W
V
E
K
I
L
Q
L
H
Q
I
L
N
I
NH
G
V
M
M
V
G
P
S
GGG
K
T
T
S
W
E
V
Y
L
E
A
I
E
Q
V
DN
I
K
S
E
A
H
V
M
DPKAITKDQLF
G
S
L
D
LTTR
E
W
T
D
G
L
F
T
A
T
L
R
R
I
I
D
NVRGEST
K
R
H
W
I
I
F
D
G
D
V
D
PEWVENLNSLLDDNK
L
L
T
L
PNGE
R
L
A
L
P
NN
V
R
V
M
F
E
V
QDLKYATLATISR
C
G
M
V
W
F
S
EEILT
T
Q
M
I
F
Q
N
Y
L
D
T
L
S
N
E
PFD
P
Q
E
K
E
Q
Q
K
R
N
E
N
AIP
A
G
L
K
V
Q
K
E
C
A
A
I
I
SQYFEPGG
L
V
H
K
V
L
E
D
A
G
Q
RPHIMDFT
R
L
R
V
L
N
S
F
F
S
L
M
N
R
S
I
V
N
V
I
E
Y
N
Q
L
HSDFPMS
P
E
N
Q
S
N
Y
I
T
N
R
L
L
Y
S
L
M
W
GLGGSMG
L
V
E
R
E
N
F
S
K
F
I
Q
T
I
AITPVPANTIPLLD
Y
S
V
S
IDDA
N
W
S
L
WKNK
V
E
V
E
T
H
K
V
A
S
P
D
V
V
I
P
T
V
D
T
T
R
H
V
D
V
L
H
A
W
L
S
E
H
R
P
-------
L
I
L
C
G
P
P
G
S
G
K
T
M
T
L
T
S
T
L
R
A
F
P
D
F
E
V
V
S
L
N
F
S
S
A
T
T
P
E
L
L
L
K
T
F
D
H
H
C
E
Y
K
R
T
P
S
G
E
---------
T
V
L
R
P
T
Q
L
------
G
K
W
L
V
V
F
C
D
E
I
NL
P
S
T
D
-----------
K
-----
Y
G
T
----
Q
-----------
R
V
-------
I
T
--------
F
I
R
Q
M
--
V
E
K
G
G
F
W
-
R
T
S
D
H
T
W
I
K
L
D
K
I
Q
F
V
G
A
C
N
PP
T
D
A
G
R
V
Q
L
T
H
-
R
F
L
R
--
H
----
A
P
-
I
L
---
L
---
V
D
F
--
P
S
T
S
S
L
T
Q
I
Y
G
T
F
N
R
A
L
--------------
M
K
L
L
--
P
N
L
R
--
S
F
A
D
N
L
T
D
A
M
V
E
F
Y
S
E
S
Q
K
R
F
---
T
P
D
I
Q
A
H
Y
I
--
Y
S
P
R
E
L
S
R
W
D
R
A
L
L
E
A
I
Q
T
M
D
G
C
T
L
E
G
L
V
R
L
W
A
H
E
A
L
R
L
FQDRLVE
T
E
E
K
E
W
T
D
K
K
I
D
E
V
A
L
K
H
F
PSVNLDALKRPILYSNWLTPVN
R
S
D
L
R
E
Y
V
K
A
R
L
K
V
F
YPLVLF
N
E
V
L
D
H
I
L
R
I
D
R
V
F
R
Q
PQG
H
A
L
L
I
G
V
SGGG
K
S
V
L
S
R
F
V
A
W
M
N
G
L
S
I
Y
T
I
KYK
S
S
D
F
D
D
D
L
R
M
L
L
K
R
A
GCKE
E
K
I
C
F
I
F
D
ESNVLE
S
S
F
L
E
R
M
N
T
L
L
A
GGEVPGLFE
G
E
E
F
T
A
L
M
H
A
C
K
E
T
A
Q
R
N
GLILDS
E
E
E
L
Y
K
Y
F
T
S
Q
V
R
R
N
L
H
V
V
F
T
M
N
PASPDFHNS
P
A
L
F
N
R
C
VLDWFGEWS
P
E
A
L
F
Q
V
G
S
E
F
T
RNLDLENPQ
Y
I
A
P
P
V
F
I
Q
E
A
EILMAIPPS
H
R
D
A
V
V
S
S
L
V
Y
I
H
Q
T
I
G
E
A
N
I
R
L
L
K
R
QG
R
Q
N
Y
V
T
P
R
H
Y
L
D
F
I
N
Q
V
V
L
L
I
N
E
K
R
D
Q
L
E
E
E
Q
L
H
L
N
I
G
L
K
K
L
R
D
T
E
A
Q
V
K
D
L
Q
V
S
L
A
Q
K
N
R
E
L
D
V
K
N
E
Q
A
N
Q
K
L
K
Q
M
V
Q
D
Q
Q
A
A
E
I
K
Q
K
D
A
R
E
L
Q
V
Q
L
D
V
R
N
K
E
I
A
V
Q
K
V
K
A
Y
A
D
LP
L
R
E
E
V
E
Q
L
E
N
A
A
N
E
L
K
L
K
Q
D
E
I
V
A
T
I
T
A
L
E
K
S
I
A
T
Y
K
E
E
Y
A
T
L
I
R
E
T
E
Q
I
K
T
E
S
S
K
V
K
N
K
V
D
R
S
I
A
L
L
D
N
L
N
S
E
R
G
R
W
E
Q
Q
S
E
N
F
N
T
Q
M
S
T
V
V
G
D
V
V
L
A
S
A
F
L
A
YIGFFD
Q
N
F
R
T
D
L
M
R
K
W
M
I
R
L
D
S
V
GIKFKSDLS
V
P
S
F
L
SK
P
E
E
R
L
N
W
H
A
N
SLPSD
E
L
C
I
E
N
A
I
M
L
K
RFNRYPLVIDPSG
Q
A
M
E
F
L
M
N
Q
Y
A
DKKITKTSF
M
K
N
L
E
S
A
L
R
F
G
C
P
L
L
V
Q
DVES
F
M
I
F
L
F
T
RDPT
A
H
F
T
P
D
L
C
S
R
V
T
F
V
N
FTVT
P
S
S
L
Q
S
Q
C
L
H
E
A
L
K
T
ERP
D
T
H
K
K
R
S
DLLKIQGEFQVKLR
I
L
E
K
S
L
L
N
A
L
S
Q
A
SGNILDD
D
S
V
I
S
T
L
E
T
L
K
K
E
TT
E
I
A
L
K
V
E
E
T
E
T
V
M
Q
E
I
S
E
V
S
A
L
Y
N
P
M
A
L
S
C
S
R
V
Y
F
A
M
E
E
L
SQFHL
Y
Q
F
S
L
R
A
F
L
D
I
F
Y
N
L
L
NNNPNLVDKKD
P
N
E
R
L
V
Y
L
S
K
D
I
F
S
M
T
F
N
R
V
T
R
T
LLNDD
K
L
T
F
A
L
Q
L
T
I
I
S
V
KGTSNEIE
E
S
E
W
D
F
L
L
KGGDNLTSIKETIPQLDSLLS
T
T
Q
Q
K
W
L
I
C
L
R
Q
QVPSFSK
L
V
D
H
I
Q
Q
N
SSDWKQFFGKDQVGEPIIP
E
S
W
I
V
A
Q
A
Q
L
S
NQQS
T
I
V
S
N
F
R
K
I
L
L
M
K
A
FHSDR
V
L
Q
Y
S
H
S
F
V
C
S
V
FGEDFLNTLD
M
A
N
I
V
E
KEVKSS
S
P
L
L
LCSVPGYDA
S
S
K
V
D
D
L
A
L
Q
L
H
K
Q
Y
K
S
F
A
I
GSPEGFELAEK
S
I
Y
A
A
A
K
SG
T
W
V
L
L
K
NIHLAPQWL
V
Q
L
E
K
K
L
H
S
L
S
P
H
PS
F
R
L
F
M
T
S
E
IHPALP
A
N
L
L
R
M
S
N
V
F
S
Y
E
NPPG
V
K
A
N
L
L
H
T
F
I
G
IP
A
T
R
M
D
KQPAE
R
S
R
I
Y
F
L
L
A
W
F
H
A
I
I
Q
E
R
L
RYIPLGWTKFFEFN
D
A
D
L
R
G
A
L
D
S
I
D
Y
W
V
D
L
Y
SKGRSNIDPDKIP
W
I
A
V
R
T
I
L
G
STIYGGRIDN
E
F
D
M
R
L
L
Y
S
F
L
E
Q
L
F
TPSAFNPDFPLVPSIGL
S
V
P
E
G
TT
R
A
H
F
M
K
W
I
E
A
LPEISTPIWLGLPEN
A
E
S
L
L
L
S
N
K
A
R
K
M
I
N
D
L
Q
K
M
Q
S
S
E
E
DS
S
S
S
E
D
K
G
K
A
KP
L
F
R
C
F
E
R
E
I
S
T
G
G
K
L
V
K
K
I
T
N
D
L
A
N
L
LKW
Y
S
V
P
ETIS
L
S
V
W
I
S
D
F
S
K
R
M
Q
Q
L
S
E
I
S
E
SVWLGGLLN
P
E
A
Y
I
T
A
T
R
Q
S
A
S
Q
L
NGRLHASA
S
F
N
V
K
G
M
A
L
E
G
A
V
W
N
ND
Q
L
T
P
TDIL
S
T
P
I
S
I
A
T
L
T
W
K
DPIFNNSSS
K
L
S
V
P
V
Y
LNETRSELL
F
S
I
D
L
P
Y
DQSTS
K
Q
N
W
Y
Q
R
S
V
S
I
S
SWKSD
140
Fugue
70.31
19%
-59
- C4 -
-
5C3C
1
?
B:
[26-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
P
Y
Y
R
A
V
Q
D
E
I
E
L
Y
R
A
G
Y
E
A
R
---
I
P
-------
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
K
L
-
N
R
P
L
I
T
I
A
C
-
N
E
D
M
T
A
S
D
L
V
D
G
P
L
T
V
A
A
R
I
G
------------------------------
A
I
C
Y
L
D
E
I
-----
V
-----------
E
-----
A
R
Q
----
D
-----------
T
I
-------
V
---------
V
I
H
P
L
TD
H
R
R
-
V
L
P
-
L
E
K
K
G
E
L
V
E
A
H
P
D
F
Q
I
V
I
----
S
Y
N
D
---
L
K
Q
-
S
T
K
Q
--
R
----
F
G
-
A
L
---
D
---
F
D
Y
--
P
K
P
D
I
E
A
E
I
V
S
H
E
A
-
G
V
D
K
D
T
A
E
K
L
V
Q
I
A
Q
K
A
R
N
L
KG
H
G
L
D
E
G
L
S
T
R
L
L
V
Y
A
G
K
L
I
A
K
G
V
D
A
R
A
A
C
T
M
T
--------
L
V
N
P
I
T
D
D
V
D
M
R
D
A
L
D
T
V
V
K
T
F
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
67.47
22%
-49
- C4 -
-
5C3C
1
?
A:
[38-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Y
R
A
G
Y
E
A
R
---
I
P
-------
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
K
L
-
N
R
P
L
I
T
I
A
C
N
E
D
M
T
A
S
D
L
V
G
R
---------------------------
D
G
P
L
T
V
A
--
A
R
I
G
A
I
C
Y
L
D
E
I
-----
V
-----------
E
-----
A
R
Q
----
D
-----------
T
I
-------
V
V
--------
I
H
P
L
T
--
D
H
R
-
R
V
L
P
L
E
K
K
G
E
L
V
E
A
H
P
D
F
Q
I
V
I
----
S
Y
N
P
--
D
L
K
Q
-
S
T
K
Q
--
R
----
F
G
-
A
L
---
D
---
F
D
Y
--
P
K
P
D
I
E
A
E
I
V
S
H
E
A
-
G
V
D
K
D
T
A
E
K
L
V
Q
I
A
Q
K
A
R
N
--------
G
L
S
T
R
L
L
V
Y
A
G
K
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
66.75
22%
-73
- C4 -
-
5C3C
1
?
B:
[38-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Y
R
A
G
Y
E
A
R
---
I
P
-------
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
K
L
-
N
R
P
L
I
T
I
A
C
N
E
D
M
T
A
S
D
L
V
-----------------------------
D
G
P
L
T
V
A
--
A
R
I
G
A
I
C
Y
L
D
E
I
-----
V
-----------
E
-----
A
R
Q
----
D
-----------
T
I
-------
V
V
--------
I
H
P
L
T
--
D
H
R
-
R
V
L
P
L
E
K
K
G
E
L
V
E
A
H
P
D
F
Q
I
V
I
----
S
Y
N
---
D
L
K
Q
-
S
T
K
Q
--
R
----
F
G
-
A
L
---
D
---
F
D
Y
--
P
K
P
D
I
E
A
E
I
V
S
H
E
A
-
G
V
D
K
D
T
A
E
K
L
V
Q
I
A
Q
K
A
R
N
L
KG
H
G
L
D
E
G
L
S
T
R
L
L
V
Y
A
G
K
L
I
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.97
25%
-
- C4 -
-
5T0G
-
PRS10_HUMAN
E:
[168-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
C
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
S
Q
L
-
D
C
N
F
L
K
V
----------------
V
S
S
S
I
V
D
K
Y
I
G
E
S
A
RL
I
R
E
M
F
N
Y
A
R
---------
D
H
Q
P
C
I
I
F
M
D
E
I
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
N
Q
M
D
G
F
D
-
T
L
H
R
V
K
M
I
M
A
T
N
R
P
-------------
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
RKI
H
---
I
D
L
--
P
N
E
Q
A
R
L
D
I
L
K
I
H
A
G
P
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.69
25%
-
- C4 -
-
5T0H
-
PRS10_HUMAN
E:
[168-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
C
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
S
Q
L
-
D
C
N
F
L
K
V
----------------
V
S
S
S
I
V
D
K
Y
I
G
E
S
A
R
L
I
R
E
M
F
N
Y
A
R
---------
D
H
Q
P
C
I
I
F
M
D
E
I
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
N
Q
M
D
G
F
D
-
T
L
H
R
V
K
M
I
M
A
T
N
R
P
-------------
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
R
K
I
H
---
I
D
L
--
P
N
E
Q
A
R
L
D
I
L
K
I
H
A
G
P
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Fugue
65.10
20%
46
- C2 -
-
5E7P
5
?
B:
[18-744]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
L
S
H
L
R
L
T
A
R
L
NTSALDSRRG
V
V
R
L
H
P
E
V
L
A
A
L
GIREW
D
A
V
A
L
T
G
T
R
T
T
A
A
V
A
G
VAGPGVPAG
T
A
L
L
D
D
V
T
L
S
N
A
GVREN
A
A
V
L
V
S
P
V
T
V
Y
GAR
S
V
T
V
S
G
S
R
L
A
T
Q
SIS
P
A
T
L
R
M
A
L
LG
K
V
M
T
VG
D
T
V
S
LLPRDS
A
A
T
S
A
L
A
S
S
V
GITWTS
E
L
L
T
V
TAVDPP
G
T
V
S
V
Q
PN
S
V
V
S
WGPPTG
R
H
T
V
S
P
Q
RSEQPVS
F
D
D
V
K
V
T
HPQ
A
V
K
L
D
E
W
L
R
L
S
L
DE
P
E
L
L
K
T
L
GATP
H
L
G
V
L
V
S
G
P
AGVG
K
A
T
M
V
R
A
V
C
A
S
R
R
V
V
E
L
D
G
P
E
V
G
A
LQ
V
D
E
R
L
R
S
V
T
S
A
V
A
A
V
T
E
SG
G
V
L
F
I
A
DVDALLPAGNEMRPPE
P
V
A
T
L
I
L
A
E
L
R
K
A
V
A
TPG
V
A
F
I
A
T
S
AVPENVDARLRAPEVCD
R
E
L
G
L
S
L
P
D
A
T
A
R
R
S
L
L
E
M
L
L
RG
V
P
S
E
DLD
L
G
D
I
A
D
H
T
PGFV
V
A
D
L
A
A
V
V
R
E
G
A
L
R
A
A
A
R
A
S
S
S
D
D
D
P
V
L
R
H
A
D
L
E
G
A
L
T
V
IRPLSRSASEEVSVGS
V
T
L
D
D
V
G
D
M
V
E
T
K
R
A
L
T
E
A
V
L
W
P
L
Q
H
P
D
T
F
S
---
R
L
GIDPP
R
G
V
L
L
Y
G
P
P
G
C
G
K
T
F
V
V
R
A
L
A
S
S
G
-
R
L
---------------------
S
V
H
A
V
K
G
S
E
L
M
D
K
W
--
V
G
S
S
E
K
A
V
R
--
E
L
F
A
R
A
R
D
S
A
P
S
L
V
F
L
D
E
I
-----
D
-----------
A
LAPRG
V
T
D
----
K
-----------
V
V
-------
A
S
--------
L
L
T
E
L
--
D
G
I
-
E
-------------
P
L
R
D
V
V
V
L
----
G
A
T
N
R
P
D
L
I
D
-
P
A
L
L
--
R
PGRL
E
R
-
L
V
---
F
---
V
E
P
--
P
D
A
A
A
R
R
D
I
L
R
T
A
G
K
S
I
P
L
---
A
D
D
V
D
L
D
S
L
A
D
D
L
--
D
G
Y
----
S
A
A
D
C
V
A
L
L
R
E
S
A
M
T
A
M
R
R
S
I
D
A
A
D
V
T
A
A
D
V
A
K
A
R
E
T
-
V
R
P
S
L
D
P
A
Q
V
E
S
L
R
E
F
A
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.99
27%
-48
- C4 -
-
4WW0
1
FTSH_AQUAE
A:
[52-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
----
G
A
A
R
V
R
D
---------------------
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
-----
D
A
V
G
--------
R
--------------------------E
R
E
Q
T
L
-
N
Q
--------
L
L
V
E
M
--
D
G
-------
F
D
T
S
D
G
I
------
I
V
I
A
----
A
T
N
R
P
D
I
L
D
P
-
A
L
L
R
--
P
----
G
R
-
F
D
R
Q
I
F
---
I
P
K
--
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.82
25%
-
- C4 -
-
5T0I
-
PRS10_HUMAN
E:
[168-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
C
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
S
Q
L
-
D
C
N
F
L
K
V
----------------
V
S
S
S
I
V
D
K
Y
I
G
E
S
A
R
L
I
R
E
M
F
N
Y
A
R
---------
D
H
Q
P
C
I
I
F
M
D
E
I
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
N
Q
M
D
G
F
D
-
T
L
H
R
V
K
M
I
M
A
T
N
R
P
-------------
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
R
K
I
H
---
I
D
L
--
P
N
E
Q
A
R
L
D
I
L
K
I
H
A
G
P
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.72
24%
-59
- C4 -
-
2R62
-
FTSH_HELPY
A:
[204-386]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
----
G
A
S
R
V
R
D
---------------------
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
-----
D
AIGK-----------------------------------------
N
D
EREQTLNQ
L
L
A
E
M
--
D
G
F
-
G
------------
S
E
N
A
P
V
I
V
L
----
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
--
P
----
G
R
-
F
D
R
Q
V
L
---
V
D
K
--
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
N
D
-----
V
N
L
Q
E
V
--
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.71
25%
-
- C4 -
-
5T0J
-
PRS10_HUMAN
E:
[168-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
C
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
S
Q
L
-
D
C
N
F
L
K
V
----------------
V
S
S
S
I
V
D
K
Y
I
G
E
S
A
RL
I
R
E
M
F
N
Y
A
R
---------
D
H
Q
P
C
I
I
F
M
D
E
I
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
N
Q
M
D
G
F
D
-
T
L
H
R
V
K
M
I
M
A
T
N
R
P
-------------
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
RKI
H
---
I
D
L
--
P
N
E
Q
A
R
L
D
I
L
K
I
H
A
G
P
I
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.10
24%
-70
- C4 -
-
2R65
1
FTSH_HELPY
A:
[45-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
----
G
A
S
R
V
R
D
---------------------
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
-----
D
AIGK-----------------------------------------
N
D
EREQTL
N
Q
L
L
A
E
M
--
D
G
F
-
G
------------
S
E
N
A
P
V
I
V
L
----
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
--
P
----
G
R
-
F
D
R
Q
V
L
---
V
D
K
--
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
N
D
-----
V
N
L
Q
E
V
--
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.41
27%
-39
- C4 -
-
4Z8X
1
FTSH_AQUAE
A:
[52-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
----
G
A
A
R
V
R
D
---------------------
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
-----
D
AVG--------
R
--------------------------D
E
R
E
Q
T
L
N
Q
--------
L
L
V
E
M
--
D
G
-------
F
D
T
S
D
G
I
------
I
V
I
A
----
A
T
N
R
P
D
I
L
D
P
-
A
L
L
R
--
P
----
G
R
-
F
D
R
Q
I
F
---
I
P
K
--
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.08
24%
-65
- C4 -
-
4CR3
-
PRS10_YEAST
L:
[216-371]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
A
T
I
-
G
A
N
F
I
----------------
F
S
P
A
S
G
I
V
D
K
Y
I
G
E
S
-------
A
R
I
I
R
--
E
M
F
A
Y
A
K
E
H
E
P
C
I
I
F
M
D
E
V
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
T
Q
M
-
D
G
F
------
D
N
L
G
Q
T
K
---
I
I
M
----
A
T
N
R
P
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
---
R
K
V
E
I
P
L
--
P
N
E
A
G
R
L
E
I
F
K
I
H
T
A
K
V
K
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.05
24%
-65
- C4 -
-
5A5B
-
PRS10_YEAST
L:
[216-371]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
A
T
I
-
G
A
N
F
I
----------------
F
S
P
A
S
G
I
V
D
K
Y
I
G
E
S
-------
A
R
I
I
R
--
E
M
F
A
Y
A
K
E
H
E
P
C
I
I
F
M
D
E
V
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
T
Q
M
-
D
G
F
------
D
N
L
G
Q
T
K
---
I
I
M
----
A
T
N
R
P
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
---
R
KVE
I
P
L
--
P
N
E
A
G
R
L
E
I
F
K
I
H
T
A
K
V
K
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.99
24%
-53
- C4 -
-
4CR4
-
PRS10_YEAST
L:
[216-371]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
V
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
A
T
I
-
G
A
N
F
I
----------------
F
S
P
A
S
G
I
V
D
K
Y
I
G
E
S
-------
A
R
I
I
R
--
E
M
F
A
Y
A
K
E
H
E
P
C
I
I
F
M
D
E
V
-----
D
AIGGRRFSEGT
S
-----
A
D
R
----
E
-----------
I
Q
-------
R
T
--------
L
M
E
L
L
--
T
Q
M
-
D
G
F
------
D
N
L
G
Q
T
K
---
I
I
M
----
A
T
N
R
P
D
T
L
D
P
-
A
L
L
R
--
P
----
G
R
-
L
D
---
R
K
V
E
I
P
L
--
P
N
E
A
G
R
L
E
I
F
K
I
H
T
A
K
V
K
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Fugue
62.83
17%
40
* C2 *
-
1E32
1
TERA_MOUSE
A:
[21-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRPN
R
L
I
VDEAINEDNS
V
V
S
L
S
Q
P
K
M
D
E
L
QLFR
G
D
T
V
L
L
K
G
K
KR
R
E
A
V
C
I
V
L
S
D
DTCSDE
K
I
R
M
N
R
V
V
R
N
N
L
RVRLG
D
V
I
S
I
Q
P
C
PD
V
K
Y
G
K
R
I
H
V
L
P
I
DDTVEGITGNLFEVY
L
K
P
Y
F
LEAY
R
P
I
R
K
G
D
I
F
L
V
R
GGM
R
A
V
E
F
K
VVETDPSPYCIVAPD
T
V
I
H
C
E
G
E
P
I
K
R
E
DEEESLNEVGYDD
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
---
P
P
R
G
-----
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
-------------------------
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
-----
D
-----------
A
-----
I
A
P
----
K
-----------
R
E
-------
K
T
--------
H
G
E
V
E
--
R
R
I
-
V
S
Q
-
L
L
T
L
M
D
G
L
K
-
Q
R
A
H
V
I
V
M
----
A
A
T
N
R
P
N
S
I
D
-
P
A
L
R
--
R
FG--
R
F
-
D
R
---
E
---
V
D
I
GI
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
---------------------
L
A
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
E
T
I
D
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
62.72
32%
-45
- C4 -
-
4WW0
1
FTSH_AQUAE
B:
[50-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
---
K
G
-------
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
----------------
G
V
G
---
A
A
R
V
R
D
------
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
-----
D
-----------
A
-----
V
G
R
D
E
R
E
Q
-----------
T
L
-------
N
Q
--------
L
L
V
E
M
--
D
G
F
-------------
D
T
S
D
G
I
I
V
I
A
----
A
T
N
R
P
D
I
L
D
P
-
A
L
L
R
PG
R
----
F
D
R
Q
I
---
F
---
I
P
K
--
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------