@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS07: (2017-12-05 )
MFKSFFPSPRYFFISVVIWLALNMVLWYTGGDHWGQYLGFPQGYADAELPIGVSRFWSPAFLWFYLWFLVSTALFAGFWKIISNNPWQRWSIWGAAFILFNIWFAVQVNVAINAWYVPFWDLIQKMLSSGGGDISTLYSETLVFLYIAMVYVTLGVITAFFTSHYVFRWRTAMNEYYTEHWEKLRHIEGASQRVQEDTMRFATIMEDLGVELVKSVITLIAFLPILFHLSKYVLVLPLVGELNHSLVWAAIVWSIFGTVLLMVVGIKLPGLQFNNQKVEAAYRKELVYGEDHAERAQPVTLKELFANVRKNYFRLYFHYAYFNMTATWYGQLDILYNLVVLFPSIAAGKLTLGLMQQIMNVFGRVRDSFQYLISSWKTIIELLSIYKRLKAFESILHK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.......-------.70........80........90........100.......110.......120......-.130--..-------------...----...140.......150.....----..----160---.----...-....170.......180-....---.....190.......200.......210.......220....-...-230.......240.......250.......260.......270.......280.......290..--..--..----.300.....----..310.----..----..----.----.----320.......330.......340.......350.......360.......370.......380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFKSFFPSP
R
Y
F
F
I
S
V
V
I
W
L
A
L
N
M
V
L
W
YTGG
D
H
W
G
Q
YLGFPQGYADAELPI
G
V
S
R
FW
S
P
A
F
L
W
F
Y
L
W
F
-------
L
V
S
T
A
L
F
A
G
F
W
K
I
ISNNPW
Q
R
W
S
I
W
G
A
A
F
I
L
F
N
I
W
F
A
V
Q
V
N
V
A
I
N
A
W
Y
V
P
F
W
D
L
I
Q
K
M
L
S-SG-G--G
D
-------------
I
S
T
----
L
Y
S
E
T
L
V
F
L
Y
I
A
M
V
Y
V
T
L
G
V
I
----
T
A
----
F
F
----T----S
H
Y
-
V
F
R
W
R
T
A
M
N
E
Y
Y
T
E
H
---
W
E
K
L
---
R
H
IE
G
A
S
Q
R
V
Q
E
D
T
M
R
F
A
T
I
M
E
D
L
G
V
E
L
V
K
S
V
I
T
L
I
A
F
L
P
I
L
-
F
H
L
-
S
K
Y
V
L
V
L
P
L
V
G
ELN
H
S
L
V
W
A
A
I
V
W
S
I
F
G
T
V
L
L
M
V
V
GIKLPGLQFN
N
Q
K
V
E
A
A
Y
R
K
ELVYGED
H
A
E--RA--QP----V
T
L
K
E
L
F
A
N
----
V
R
K
N
Y
F
----
R
L
----
Y
F
----
H
----
Y
----
A
Y
F
N
M
T
A
T
WYG
Q
L
D
I
L
Y
N
L
V
V
L
FPSIAA
G
K
L
T
L
G
L
M
Q
Q
I
M
N
V
F
G
R
V
R
D
S
F
Q
Y
L
I
S
S
W
K
T
I
I
E
L
L
S
I
Y
K
R
L
K
A
F
E
S
I
LHK
12
HHSearch
64.54
11%
-128
- C1 -
-
5U1D
-
TAP2_HUMAN
B:
[156-450]
---------------------------------------------------------------------------------------------------------
F
F
F
L
V
L
A
V
L
G
E
T
L
I
P
H
Y
S
G
R
V
I
D
I
L
G
G
D
F
---------
D
-------------
P
H
A
----
F
A
S
A
I
F
F
M
C
L
F
S
F
G
S
S
L
S
A
G
C
----
R
G
G
C
F
T
Y
T
----
M
----
S
R
I
-
N
L
R
I
R
E
Q
L
F
S
S
L
L
R
Q
D
L
G
F
F
Q
E
---
T
K
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
-
L
S
I
-
S
P
R
L
T
-------------
L
L
S
L
L
H
M
P
F
T
I
A
A
E
K
V
Y
N
T
R
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
A
G
Q
V
V
R
E
A
V
G
G
L
Q
T
V
R
S
F
G
A
E
----
E
H
E
V
C
R
Y
K
E
----
A
L
E
Q
C
R
----
Q
L
Y
W
R
R
D
L
----
E
----
R
----
A
L
Y
L
L
V
R
R
V
L
H
L
G
V
Q
M
L
M
L
S
C
G
L
Q
Q
M
Q
D
G
E
L
T
Q
G
S
L
L
S
F
M
I
Y
Q
E
S
V
G
S
Y
V
Q
T
L
V
Y
I
Y
G
D
M
L
S
N
V
G
A
A
E
K
V
F
S
Y
M
D
R
Q
--
9
HHSearch
64.17
13%
-116
- C1 -
-
5MKK
-
?
A:
[15-334]
----------------------------------------------------------------------------------
A
R
I
L
R
Y
V
W
P
Y
R
L
--
Q
V
V
----
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
P
R
P
L
A
--
E
R
-------------
F
H
L
----
L
L
W
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
----
E
T
----
Y
L
----
I
Q
W
V
G
Q
R
V
-
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
---
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
-
L
F
L
-
S
P
K
L
T
-------------
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
----
R
E
R
E
E
K
F
D
R
----
L
N
R
D
L
F
----
R
A
----
W
V
----
E
I
I
R
W
F
----
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
-
23
Fugue
61.32
17%
-65
- C1 -
-
4P5W
-
CMC2_HUMAN
A:
[31-394]
-------
T
K
R
-----
A
D
P
A
E
L
R
T
I
F
L
K
Y
A
S
I
E
K
N
G
E
F
F
M
S
P
N
D
F
V
T
R
Y
L
N
I
F
S
Q
P
--
N
P
K
T
V
E
L
L
S
G
V
V
DQTKDG
L
I
S
F
Q
E
F
V
A
F
E
S
V
L
C
A
P
D
----
A
L
F
M
V
A
F
Q
L
F
D
--------------------------
K
-
A
G
-
K
--
G
E
-------------
V
T
F
----
E
D
V
K
Q
V
F
G
Q
T
T
I
H
Q
H
I
P
F
N
W
D
----
S
E
----
F
V
----
Q
----
L
H
F
G
K
E
R
K
R
H
L
T
Y
A
E
F
T
Q
F
---
L
L
E
I
---
Q
L
E
H
A
K
Q
A
F
V
Q
R
D
N
A
R
-------------
T
G
R
V
T
A
I
D
F
R
D
I
M
-
V
T
I
-
R
P
H
V
L
T
---------
P
F
V
E
E
C
L
V
A
A
A
G
G
T
---------------
T
S
H
Q
V
S
F
S
Y
F
N
G
F
N
S
L
L
N
N
M
E
--
L
I
--
R
K
----
I
Y
S
T
L
A
G
T
R
----
K
D
V
E
V
T
----
K
E
----
E
F
----
V
----
L
----
A
A
Q
K
F
G
Q
V
T
P
M
E
V
D
I
L
F
Q
L
A
D
L
Y
E
P
--
R
G
R
M
T
L
A
D
I
E
R
I
A
P
P
N
P
D
H
V
G
G
Y
K
L
A
V
A
T
F
A
G
I
E
N
K
F
G
L
Y
L
-----------
10
HHSearch
61.01
12%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[14-325]
----------------------------------------------------------------------------------
K
R
L
W
T
Y
I
R
L
Y
K
A
----
G
L
--
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
---------
E
-------------
S
N
F
----
L
R
I
L
P
F
M
I
L
G
L
M
F
V
R
G
L
S
G
F
A
----
S
S
----
Y
C
LSWV
S
----
G
N
V
-
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
PV
R
F
F
D
Q
---
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
-
F
W
N
-
S
W
Q
L
S
-------------
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
----
E
V
E
R
K
R
F
D
K
----
V
S
N
S
M
R
----
Q
Q
----
T
M
----
K
L
V
S
A
Q
----
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
--
1
HHSearch
55.75
10%
-135
- C1 -
-
3QF4
-
Y288_THEMA
B:
[25-337]
---------------------------------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
------
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
---------
R
-------------
F
D
L
----
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
----
Q
G
----
K
I
----
M
L
T
L
S
Q
D
V
-
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
PV
G
F
F
D
R
---
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
-
F
R
V
-
N
V
I
L
S
-------------
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
----
E
K
E
M
E
K
F
D
R
----
V
N
E
S
L
R
----
K
V
----
G
T
----
K
A
Q
I
F
S
----
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
6
HHSearch
55.51
12%
-111
- C1 -
-
4A82
-
Y1866_STAAM
B:
[3-321]
----------------------------------------------------------------------------------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
--
R
I
F
A
----
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
-
L
T
-
T
DE
K
V
-------------
H
H
L
----
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
----
R
Q
----
Y
L
----
A
QWTS
N
K
I
-
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
SAR
F
Y
A
N
---
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
-
F
F
L
-
D
V
K
L
T
-------------
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
VV
K
S
FA
I
E
----
D
N
E
A
K
N
F
D
K
----
K
N
T
N
F
L
TRAL
K
H
----
T
R
----
W
----
N
----
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
--
18
HHSearch
54.21
11%
-95
- C1 -
-
4MYC
-
ATM1_YEAST
B:
[115-416]
---------------------------------------------------------------------------------------------------------
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
I
A
W
D
-------
D
P
-------------
T
V
A
LPAA
I
G
L
T
I
L
C
Y
G
V
A
R
F
G
S
V
L
F
G
E
L
----
R
N
----
A
V
----
F
AKVA
Q
N
A
-
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
DLG
W
H
L
S
---
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
-
G
A
S
F
A
-------------
A
I
T
F
S
T
M
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
AV
K
Y
FN
N
E
----
K
Y
L
A
D
K
Y
N
G
----
S
L
M
N
Y
R
----
D
S
----
Q
I
----
K
VSQS
L
----
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
--
4
HHSearch
53.69
13%
-113
- C1 -
-
4AYX
6
ABCBA_HUMAN
A:
[6-322]
--------------------------------------------------------------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
------
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
----
V
--
D
Y
-------------
S
D
N
----
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
----
Y
L
----
M
Q
T
S
G
Q
R
I
-
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
---
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-
F
F
V
-
S
P
N
L
A
-------------
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
----
M
T
E
I
E
K
Y
A
S
----
K
V
D
H
V
M
----
Q
L
----
A
R
----
K
----
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
--
19
HHSearch
52.94
11%
-95
- C1 -
-
4MYC
-
ATM1_YEAST
C:
[115-416]
---------------------------------------------------------------------------------------------------------
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
I
A
W
D
-------
D
P
-------------
T
V
A
LPAA
I
G
L
T
I
L
C
Y
G
V
A
R
F
G
S
V
L
F
G
E
L
----
R
N
----
A
V
----
F
AKVA
Q
N
A
-
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
DLG
W
H
L
S
---
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
-
G
A
S
F
A
-------------
A
I
T
F
S
T
M
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
AV
K
Y
FN
N
E
----
K
Y
L
A
D
K
Y
N
G
----
S
L
M
N
Y
R
----
D
S
----
Q
I
----
K
VSQS
L
----
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
K
N
E
--
13
HHSearch
52.75
11%
0
- C- -
-
5L22
-
?
B:
[10-325]
-----------------------------------------------------------------------------------
V
L
R
S
Y
L
A
K
Y
K
K
T
L
I
I
------
V
G
L
F
S
L
F
I
N
I
L
F
L
L
P
S
I
Y
M
L
A
V
Y
D
I
V
V
P
S
T
---------
S
-------------
V
P
T
----
L
L
V
I
T
A
L
A
V
V
L
Y
F
A
L
G
L
L
Q
S
V
----
R
A
----
K
V
----
M
----
Q
I
I
-
S
L
K
L
D
S
E
L
N
K
E
V
F
T
S
---
S
F
E
Y
A
I
R
N
P
S
K
A
S
A
Q
P
I
-
N
D
L
Y
Q
L
K
Q
F
L
T
S
P
V
L
F
A
I
F
D
L
P
W
V
P
I
Y
F
G
V
L
-
F
V
F
-
H
V
Y
Y
G
V
-------------
M
A
I
L
S
M
A
V
I
V
A
L
A
I
L
N
E
Y
I
T
K
K
K
L
K
E
S
N
E
L
L
V
R
S
T
N
F
L
N
R
A
L
L
N
A
E
V
V
E
A
L
G
M
R
N
N
L
Y
K
K
W
M
N
F
Y
S
K
----
H
L
S
A
F
E
----
E
A
----
T
D
----
R
----
N
----
N
F
L
S
N
L
T
R
I
F
R
I
M
A
Q
S
L
M
L
G
L
G
G
Y
L
A
I
K
H
E
I
T
T
G
M
I
V
A
G
S
I
L
L
G
R
I
L
G
P
I
D
T
I
V
N
G
W
R
Q
I
G
N
T
K
V
A
Y
T
R
L
N
E
F
L
K
F
L
--
5
HHSearch
52.75
13%
-116
- C1 -
-
4AYT
7
ABCBA_HUMAN
A:
[6-322]
--------------------------------------------------------------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
------
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
----
V
--
D
Y
-------------
S
D
N
----
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
----
Y
L
----
M
Q
T
S
G
Q
R
I
-
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
---
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-
F
F
V
-
S
P
N
L
A
-------------
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
----
M
T
E
I
E
K
Y
A
S
----
K
V
D
H
V
M
----
Q
L
----
A
R
----
K
----
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
--
3
HHSearch
52.02
8%
-164
- C1 -
-
5MKK
-
?
B:
[9-319]
---------------------------------------------------------------------------------
L
R
R
L
W
P
Y
V
G
R
Y
R
W
R
----
Y
--
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
----------
R
-------------
G
------
F
G
V
Y
A
L
A
I
V
A
S
A
A
L
S
G
L
L
S
Y
A
----
M
R
----
R
L
----
A
V
V
A
S
R
Q
V
-
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
---
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
-
Y
A
V
-
N
A
R
L
A
-------------
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
----
R
R
M
V
A
W
F
Q
D
----
L
N
R
L
Y
V
----
E
K
----
S
L
A
L
A
R
V
----
E
----
G
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
V
V
R
G
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
L
R
R
L
F
E
L
L
D
E
K
P
-
2
HHSearch
51.80
10%
-
- C1 -
-
4Q4H
-
Y288_THEMA
B:
[25-337]
---------------------------------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
------
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
---------
R
-------------
F
D
L
----
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
----
Q
G
----
K
I
----
M
L
T
L
S
Q
D
V
-
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
PV
G
F
F
D
R
---
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
-
F
R
V
-
N
V
I
L
S
-------------
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
----
E
K
E
M
E
K
F
D
R
----
V
N
E
S
L
R
----
K
V
----
G
T
----
K
A
Q
I
F
S
----
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
8
HHSearch
48.50
10%
-
- C1 -
-
4Q4H
-
?
A:
[1-314]
---------------------------------------------------------------------------------
S
K
T
L
A
R
Y
L
K
P
Y
W
I
----
F
A
--
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
---------
D
-------------
F
S
L
----
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
----
Y
A
----
S
----
Q
N
F
-
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
---
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
-
V
S
I
-
N
V
K
L
S
-------------
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
----
E
Y
E
N
E
N
F
R
K
----
A
N
E
S
L
R
----
R
S
----
I
I
----
S
----
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
-
22
HHSearch
46.03
11%
-121
- C1 -
-
3WMG
1
?
A:
[33-328]
---------------------------------------------------------------------------------------------------------
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
-------
Q
I
-------------
E
G
E
----
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
----
R
T
----
A
L
F
G
I
A
S
----
E
R
L
-
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
---
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
-
F
I
F
-
A
P
A
L
T
-------------
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
----
R
Y
E
T
Q
R
Y
G
S
----
K
L
D
P
L
Y
----
R
L
----
G
R
----
R
----
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
--
14
HHSearch
43.86
11%
-130
- C1 -
-
3WME
-
?
A:
[33-328]
---------------------------------------------------------------------------------------------------------
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
-------
Q
I
-------------
E
G
E
----
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
----
R
T
----
A
L
----
F
G
I
A
S
E
R
L
-
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
---
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
-
F
I
F
-
A
P
A
L
T
-------------
G
V
L
I
A
L
S
P
L
V
V
L
A
G
A
A
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
----
R
Y
E
T
Q
R
Y
G
S
----
K
L
D
P
L
Y
----
R
L
----
G
R
----
R
----
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
--
7
HHSearch
42.63
11%
-87
- C1 -
-
3B60
-
MSBA_SALTY
D:
[32-326]
----------------------------------------------------------------------------------------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
---------
D
-------------
R
S
V
----
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
----
S
S
----
Y
C
ISWV
S
----
G
K
V
-
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
PVA
F
F
D
K
---
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
-
F
Y
Y
-
S
W
Q
L
S
-------------
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
EV
L
I
FG
G
Q
----
E
V
E
T
K
R
F
D
K
----
V
S
N
K
M
R
----
L
Q
----
G
M
----
K
MVSA
S
----
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
-
16
HHSearch
39.03
8%
-98
- C1 -
-
5KO2
-
MDR1A_MOUSE
B:
[51-394]
------------------------------------------------------------------------------------------------------
L
V
G
T
L
A
A
I
I
H
G
V
A
L
P
L
M
M
L
I
F
G
D
M
T
D
S
F
A
S
V
G
N
V
S
K
-
N
S-
T
N
MSEADKRAMFAKL
E
E
E
----
M
T
T
Y
A
Y
Y
Y
T
G
I
G
A
G
V
L
I
V
A
Y
I
----
Q
V
----
S
F
----
W
CLAA
G
R
Q
-
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
EIG
W
F
D
V
---
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
-
G
W
K
L
T
-------------
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
TV
I
A
FG
G
Q
----
K
K
E
L
E
R
Y
N
N
NLEE
A
K
R
L
G
I
----
K
K
----
A
I
----
T
----
A
----
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
--
17
HHSearch
38.54
7%
-97
- C1 -
-
5KO2
-
MDR1A_MOUSE
A:
[53-394]
--------------------------------------------------------------------------------------------------------
G
T
L
A
A
I
I
H
G
V
A
L
P
L
M
M
L
I
F
G
D
M
T
D
S
F
A
S
V
G
N
-
V
S
K
N
S-
T
N
M
S
E
A
D
K
R
A
M
F
A
K
L
E
E
E
----
M
T
T
Y
A
Y
Y
Y
T
G
I
G
A
G
V
L
I
V
A
Y
I
----
Q
V
----
S
F
----
W
C
L
A
A
G
R
Q
-
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
---
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
-
G
W
K
L
T
-------------
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
----
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
----
K
K
----
A
I
----
T
----
A
----
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
--
20
HHSearch
38.11
8%
-98
- C1 -
-
5EG1
1
MCJD_ECOLX
B:
[29-326]
---------------------------------------------------------------------------------------------------------
L
F
I
T
S
L
S
S
I
I
I
S
I
S
P
L
I
L
A
K
I
T
D
L
L
S
G
S
L
S
----
N
--
F
S
-------------
Y
E
Y
----
L
V
L
L
A
C
L
Y
M
F
C
V
I
S
N
K
A
S
V
F
L
----
F
M
----
I
L
Q
S
S
L
R
----
I
N
M
-
Q
K
K
M
S
L
K
Y
L
R
E
L
Y
N
E
N
I
T
N
L
S
K
---
N
N
A
G
Y
T
T
Q
S
L
N
Q
A
S
N
D
I
Y
I
L
V
R
N
V
S
Q
N
I
L
S
P
V
I
Q
L
I
S
T
I
V
V
V
-
L
S
T
K
D
W
F
S
A
-------------
G
V
F
F
L
Y
I
L
V
F
V
I
F
N
T
R
L
T
G
S
L
A
S
L
R
K
H
S
M
D
I
T
L
N
S
Y
S
L
L
S
D
T
V
D
N
M
I
A
A
K
K
N
N
A
L
----
R
L
I
S
E
R
Y
E
D
----
A
L
T
Q
E
N
----
N
A
----
Q
K
----
K
Y
W
L
L
S
----
S
K
V
L
L
L
N
S
L
L
A
V
I
L
F
G
S
V
F
I
Y
N
I
L
G
V
L
N
G
V
V
S
I
G
H
F
I
M
I
T
S
Y
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
L
A
G
F
I
Q
R
H
A
E
---