@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUV2: (2017-12-20 )
MSEHRKPEQGVKLRGAEKVARIPVKVVPTVEVPRKPDWIRVKMTAPEEVQRIKTTLRAQKLHTVCEEAACPNLPECFGGGTATFMIMGDICTRRCPFCDVAHGRPNALDPDEPRHMAETIANLKLKYAVITSVDRDDLLDGGAQHFVDCIKEARALSPNTLLEILVPDFRGRMDIALRIMTECPPDVFNHNIETVPRLYKAMRPGSDYQHSLNLLKMFKEYCPDIPTKCGLMVGIGETEEEVIALLDDLRAHDVDYVTIGQYLQPSKQHAPIDRFVTPEEFERYAEHGRKLGFRNIWSAPMVRSSYFADRQYYGEPVPEVRRKVDPAKKIAVQAIEA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90---.........100..---.----..---..110.......120......-----.130.......140.......150......----.160.......170-.-----..---......180.......190...-....200..---.....210.......220....-...230...-....240....----...250--..--.....260.-..---------------..---------------..270.......280---.........290..---.....300.--......310.......320.......330.....-----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSEHRKPEQGVKLR
G
A
E
K
V
ARI
P
V
K
V
V
PTVEVPRKP
D
W
I
R
V
K
MT
A
P
E
E
V
Q
R
I
K
T
T
L
R
A
Q
K
L
H
T
V
C
E
E
AACPN
L
P
E
C
FGGG
T
A
T
F
M
I
M
G
D
I
----CTRRCPFCDVAHGR---P----NA---LDPDE
P
R
H
M
A
E
T
I
A
N
L
K
L
K
Y
A
-----
V
I
TSV
D
R
D
D
LLD
G
G
A
Q
H
F
V
D
C
I
K
E
A
RALS
P
----
N
T
L
L
E
I
LVPDFR---G-----
R
M
---
D
I
A
L
R
I
M
TEC
P
P
D
V
FNH
N
I
E
T
V
-
P
R
L
Y
K
AMRP---GS
D
Y
Q
H
S
L
N
L
L
K
M
F
K
E
YCPDIP-TKC
G
L
M
V
GI-GE
T
E
E
E
V
I
A
L
L
----
D
D
L
R
AH--DV--
D
Y
V
T
I
G
QYL-QP---------------SK---------------QHAPIDRFV
T
P
E
E
-----
F
E
R
Y
A
E
H
G
R
KLG
F
R
---NIWSAP
M
V
R
--
S
S
YFA
D
R
Q
YYGE
P
V
P
E
V
R
R
KVD
P
A
K
K
I
A
V
Q
AIEA-----------
43
HHSearch
92.48
44%
-83
- C3 -
-
5EXK
4
LIPA_MYCTU
A:
[41-328]
------------------------------
P
I
E
R
K
P
P
W
I
K
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
P
----
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
A
--
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
E
Q
A
R
N
S
R
A
L
---------------------------
42
HHSearch
92.38
44%
-92
* C3 *
-
5EXJ
3
LIPA_MYCTU
A:
[51-328]
----------------------------------------
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
P
----
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
A
--
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
E
Q
A
R
N
S
R
A
L
---------------------------
1
PsiBlast_PDB
91.62
43%
-98
- C3 -
-
5EXI
3
LIPA_MYCTU
A:
[54-319]
-------------------------------------------
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
24
PsiBlast_CBE
91.61
43%
-80
- C3 -
-
5EXK
3
LIPA_MYCTU
E:
[27-319]
---------------
G
R
R
L
L
R
L
E
V
R
N
A
Q
T
-
P
I
E
R
K
P
P
W
I
K
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
21
PsiBlast_CBE
91.29
43%
-86
- C3 -
-
5EXK
15
LIPA_MYCTU
K:
[31-319]
-------------------
L
R
L
E
V
R
N
A
Q
T
-
P
I
E
R
K
P
P
W
I
K
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
25
PsiBlast_CBE
90.97
43%
-84
- C3 -
-
5EXK
4
LIPA_MYCTU
C:
[27-319]
---------------
G
R
R
L
L
R
L
E
V
R
N
A
Q
T
-
P
I
E
R
K
P
P
W
I
K
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
3
PsiBlast_PDB
90.74
43%
-82
- C3 -
-
5EXK
4
LIPA_MYCTU
A:
[27-319]
---------------
G
R
R
L
L
R
L
E
V
R
N
A
Q
T
-
P
I
E
R
K
P
P
W
I
K
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
2
PsiBlast_PDB
90.72
43%
-96
- C3 -
-
5EXJ
3
LIPA_MYCTU
A:
[51-319]
----------------------------------------
T
R
A
R
I
G
P
E
Y
T
E
L
K
N
L
V
R
R
E
G
L
H
T
V
C
E
E
A
G
C
P
N
I
F
E
C
W
E
D
R
E
A
T
F
L
I
G
G
D
Q
----
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---
P
----
A
E
---
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
M
G
L
R
Y
A
-----
T
V
T
G
V
A
R
D
D
L
P
D
G
G
A
W
L
Y
A
A
T
V
R
A
I
K
E
L
N
P
----
S
T
G
V
E
L
L
I
P
D
F
N
---
G
-----
E
----
P
T
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
--
A
G
L
V
-
T
K
S
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
----
G
D
L
R
D
A
--
G
C
--
D
I
V
T
I
T
Q
Y
L
-
R
P
---------------
S
A
---------------
R
H
H
P
V
E
R
W
V
K
P
E
E
-----
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
---
G
V
L
A
G
P
L
V
R
--
S
S
Y
R
A
G
R
L
Y
------------------------------------
32
Fugue
82.89
47%
-14
- C3 -
-
4U0O
4
LIPA2_THEEB
B:
[8-288]
-----------------------------------
P
S
W
L
R
I
--------
S
T
V
Q
R
L
V
R
Q
Y
G
I
H
T
I
C
E
E
G
R
C
P
N
R
G
E
C
Y
G
Q
K
T
A
T
F
L
L
L
G
P
T
----
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
A--
P
----
A
A
---
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
L
G
L
R
Y
V
-----
V
L
T
S
V
A
R
D
D
L
P
D
Q
G
A
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
L
S
P
D
F
R
MDR
G
-----
R
L
SQ-
R
D
C
I
A
Q
I
V
A
A
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
P
-
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
----
K
D
L
R
R
V
--
G
C
--
D
R
L
T
L
G
Q
Y
L
-
P
P
---------------
S
L
---------------
S
H
L
P
V
V
K
Y
W
T
P
E
E
-----
F
N
T
L
G
N
I
A
R
E
L
G
F
S
---
H
V
R
S
G
P
L
V
R
--
S
S
Y
H
A
A
E
--------------------------------------
4
PsiBlast_PDB
82.36
46%
-31
- C3 -
-
4U0O
4
LIPA2_THEEB
B:
[8-286]
-----------------------------------
P
S
W
L
R
--------
I
S
T
V
Q
R
L
V
R
Q
Y
G
I
H
T
I
C
E
E
G
R
C
P
N
R
G
E
C
Y
G
Q
K
T
A
T
F
L
L
L
G
P
T
----
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
A--
P
----
A
A
---
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
L
G
L
R
Y
V
-----
V
L
T
S
V
A
R
D
D
L
P
D
Q
G
A
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
L
S
P
D
F
R
MDR
G
-----
R
L
SQR
D
C
I
A
Q
I
V
A
A
-
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
P
-
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
----
K
D
L
R
R
V
--
G
C
--
D
R
L
T
L
G
Q
Y
L
-
P
P
---------------
S
L
---------------
S
H
L
P
V
V
K
Y
W
T
P
E
E
-----
F
N
T
L
G
N
I
A
R
E
L
G
F
S
---
H
V
R
S
G
P
L
V
R
--
S
S
Y
H
A
----------------------------------------
5
PsiBlast_PDB
80.57
46%
-28
- C3 -
-
4U0P
3
LIPA2_THEEB
B:
[8-286]
-----------------------------------
P
S
W
L
R
K
P
L
G
K
A
S
E
I
S
T
V
Q
R
L
V
R
Q
Y
G
I
H
T
I
C
E
E
G
R
C
P
N
R
G
E
C
Y
G
Q
K
T
A
T
F
L
L
L
G
P
T
----
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
A--
P
----
A
A
---
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
L
G
L
R
Y
V
-----
V
L
T
S
V
A
R
D
D
L
P
D
Q
G
A
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
L
S
P
D
F
R
MDR
G
-----
R
L
SQR
D
C
I
A
Q
I
V
A
A
-
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
P
-
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
----
K
D
L
R
R
V
--
G
C
--
D
R
L
T
L
G
Q
Y
L
-
P
P
---------------
S
L
---------------
S
H
L
P
V
V
K
Y
W
T
P
E
E
-----
F
N
T
L
G
N
I
A
R
E
L
G
F
S
---
H
V
R
S
G
P
L
V
R
--
S
S
Y
H
A
----------------------------------------
44
HHSearch
80.45
43%
-13
- C3 -
-
4U0P
3
LIPA2_THEEB
B:
[5-288]
--------------------------------
R
P
L
P
S
W
L
R
K
P
L
G
K
A
S
E
I
S
T
V
Q
R
L
V
R
Q
Y
G
I
H
T
I
C
E
E
G
R
C
P
N
R
G
E
C
Y
G
Q
K
T
A
T
F
L
L
L
G
P
T
----
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
---
A
P---
A
A
---
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
L
G
L
R
Y
V
-----
V
L
T
S
V
A
R
D
D
L
P
D
Q
G
A
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
L
S
P
D
F
R
---
M
DRGRL
S
Q
---
R
D
C
I
A
Q
I
V
A
A
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
P
-
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
----
K
D
L
R
R
V
--
G
C
--
D
R
L
T
L
G
Q
Y
L
P
P
S
---------------
L
S
---------------
H
L
P
-
V
V
K
Y
W
T
P
E
E
-----
F
N
T
L
G
N
I
A
R
E
L
G
F
S
---
H
V
R
S
G
P
L
V
R
--
S
S
Y
H
A
A
E
--------------------------------------
45
HHSearch
80.20
43%
-17
- C3 -
-
4U0O
4
LIPA2_THEEB
B:
[8-288]
-----------------------------------
P
S
W
L
R
--------
I
S
T
V
Q
R
L
V
R
Q
Y
G
I
H
T
I
C
E
E
G
R
C
P
N
R
G
E
C
Y
G
Q
K
T
A
T
F
L
L
L
G
P
T
----
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
---
A
P---
A
A
---
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
L
G
L
R
Y
V
-----
V
L
T
S
V
A
R
D
D
L
P
D
Q
G
A
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
L
S
P
D
F
R
---
M
DRGRL
S
Q
---
R
D
C
I
A
Q
I
V
A
A
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P
D
I
P
-
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
----
K
D
L
R
R
V
--
G
C
--
D
R
L
T
L
G
Q
Y
L
P
P
S
---------------
L
S
---------------
H
L
P
-
V
V
K
Y
W
T
P
E
E
-----
F
N
T
L
G
N
I
A
R
E
L
G
F
S
---
H
V
R
S
G
P
L
V
R
--
S
S
Y
H
A
A
E
--------------------------------------
33
Fugue
49.70
15%
4
- C3 -
-
1R30
4
BIOB_ECOLI
A:
[27-338]
---------------------------------------
R
P
R
W
T
L
S
Q
V
T
E
L
F
E
K
P
------
L
L
D
L
L
F
E
A
Q
Q
V
H
R
Q
H
F
D
P
R
Q
V
Q
V
S
T
L
L
S
I
KTGA
C
P
E
D
C
K
Y
C
P
Q
S
S
R
Y
---
K
----
T
G
---
L
E
A
E
R
L
M
E
V
E
Q
V
L
E
S
A
R
K
A
K
A
A
GST
R
F
C
M
G
A
A
W
K
N
P
H
E
R
D
M
P
Y
L
E
Q
M
V
Q
G
V
K
A
M
G
L
----
E
A
C
M
T
L
G
T
L
S
----------------
E
S
Q
A
Q
R
L
A
N
A
G
L
D
Y
Y
N
H
N
L
D
T
S
-
P
E
F
Y
G
N
I
I
T
---
T
R
T
Y
Q
E
R
L
D
T
L
E
K
V
R
D
A
G
I
K
V
C
-
S
--
G
G
I
V
G
L
-
G
E
T
V
K
D
R
A
G
L
L
----
L
Q
L
A
N
L
--
P
T
PP
E
S
V
P
I
N
M
L
V
-
K
V
---------------
K
G
TPLAD
N
D
D
V
D
A
F
D
F
I
R
T
I
A
V
A
R
I
M
M
P
T
S
-----
Y
V
R
L
S
-
A
G
R
E
Q
M
N
E
---
Q
T
Q
A
M
C
F
M
A
GA
N
S
I
F
Y
G
C
K
L
L
T
T
P
N
P
E
E
D
K
D
L
Q
L
F
R
K
L
G
L
N
P
Q
Q
T
-----------
62
HHSearch
47.75
16%
-34
- C3 -
-
4WCX
4
?
A:
[95-299]
---------------------------------------------------------------------------------
F
A
P
L
Y
V
S
N
Y
----
C
V
N
N
C
R
Y
C
G
Y
R
H
S
N
E
Q
Q
R
----
K
K
---
L
T
M
E
E
V
R
R
E
V
E
I
L
E
E
M
G
H
K
R
L
-----
A
V
E
A
G
E
D
P
V
N
C
P
--
I
D
Y
I
V
D
V
I
K
T
I
Y
D
T
K
L
KNGS
I
R
R
V
N
V
N
I
A
A
T
----------
T
V
----
E
N
Y
K
K
L
K
K
V
G
I
G
T
Y
V
L
F
Q
E
T
Y
H
R
P
T
Y
E
Y
M
H
P
QGP
K
H
D
Y
D
Y
H
L
T
A
M
D
R
A
M
E
A
--
G
I
D
D
V
G
L
G
V
L
Y
G
L
-
Y
D
Y
K
Y
E
T
V
A
M
L
Y
H
A
N
H
L
E
E
K
F
GV
G
P
--
H
T
I
S
V
P
R
L
R
P
A
L
---------------
N
I
----------------------------------------------------------------------------------------------------------
35
Fugue
45.93
16%
7
- C3 -
-
3T7V
2
PYLB_METBF
A:
[12-348]
-
S
L
G
D
K
V
I
E
G
Y
Q
L
T
D
N
D
L
R
T
L
L
-------------------
S
L
E
S
K
E
G
L
E
R
L
Y
S
A
A
R
K
V
R
D
H
Y
F
G
N
R
V
F
L
N
C
F
I
Y
F
S
-----------
T
Y
----
C
K
N
Q
C
S
F
C
Y
Y
N
C
R
N
---
E
----
I
N
R
Y
R
L
T
M
E
E
I
K
E
T
C
K
T
L
K
G
A
G
F
H
M
V
-----
D
L
T
M
G
E
-
D
P
Y
Y
Y
E
D
P
N
R
F
V
E
L
V
Q
I
V
K
E
E
L
G
----
L
P
----
I
M
I
S
P
G
---
L
-----
M
D
---
N
A
T
L
L
K
A
R
E
K
G
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
E
L
Y
R
K
L
R
V
---
G
Q
S
F
D
G
R
V
N
A
R
R
F
A
K
Q
--
Q
G
Y
C
-
V
E
D
G
I
L
T
G
V
-
G
N
D
I
E
S
T
I
L
S
L
----
R
G
M
S
T
N
--
D
P
--
D
M
V
R
V
M
T
F
L
-
P
Q
EGTPLEGFRDKSNLS
E
L
---------------
K
I
I
S
V
L
R
L
M
F
P
K
R
L
I
P
AS
L
D
L
E
G
I
D
G
M
V
L
R
L
N
A
G
A
N
I
V
T
S
I
L
P
P
--
D
S
Q
L
E
G
V
A
N
Y
D
R
D
L
E
E
R
D
R
D
I
K
S
V
V
R
R
L
E
I
M
G
M
K
P
A
R
Q
A
D
F
E
A
V
L
50
HHSearch
45.12
23%
13
- C3 -
-
5FEW
3
HYDE_THEMA
A:
[64-247]
---------------------------------------------------------------------------------
R
A
I
I
E
F
S
N
V
----
C
R
K
N
C
L
Y
C
G
L
R
R
D
N
---
K
N
L
K
R
Y
R
---
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
G
A
K
T
I
-----
V
L
Q
S
G
E
D
P
Y
Y
M
---
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
------
V
A
V
T
L
S
L
G
E
W
----------
P
R
----
E
Y
Y
E
K
W
K
E
A
G
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
H
R
K
L
R
P
---
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
--
G
Y
E
-
T
G
A
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
----
L
F
L
K
E
H
--
D
F
--
D
M
V
G
I
G
P
F
I
P
H
P
---------------
D
T
---------------
P
------------------------------------------------------------------------------------------
27
PsiBlast_CBE
43.54
34%
-73
- C3 -
-
5FF4
2
HYDE_THEMA
A:
[175-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
L
H
R
K
L
R
P
---
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
---
T
G
A
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
----
L
F
L
K
E
H
--
D
F
--
D
M
V
G
I
G
P
F
I
------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
43.27
34%
-79
- C3 -
-
4JY9
1
HYDE_THEMA
A:
[165-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
L
H
R
K
L
R
P
---
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
---
T
G
A
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
----
L
F
L
K
E
H
--
D
F
--
D
M
V
G
I
G
P
F
I
------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
43.17
18%
-13
- C3 -
-
3T7V
2
PYLB_METBF
A:
[61-245]
--------------------------------------------------------------------------------
L
N
C
F
I
Y
F
S
T
Y
----
C
K
N
Q
C
S
F
C
Y
Y
N
C
R
N
---
E
I
N
R
-
Y
R
---
L
T
M
E
E
I
K
E
T
C
K
T
L
K
G
A
G
F
H
M
V
-----
D
L
T
M
G
E
D
P
Y
Y
Y
-
E
D
P
N
R
F
V
E
L
V
Q
I
V
K
E
E
L
G
-----
L
P
I
M
--
I
S
P
G
L
---
M
-----
D
N
----
A
T
L
L
K
A
R
E
K
G
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
E
L
Y
R
K
L
R
V
---
G
Q
S
F
D
G
R
V
N
A
R
R
F
A
K
Q
Q
--
G
Y
C
-
V
E
D
G
I
L
T
G
V
-
G
N
D
I
E
S
T
I
L
S
L
----
R
G
M
S
T
N
--
D
P
--
D
M
V
R
V
M
T
F
L
P
Q
E
---------------
G
T
----------------------------------------------------------------------------------------------------------