@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYY8: (2017-12-15 )
MTKIAVEKVSAEEARLMSTGFLFPGQGSQKLGMLADIPEMYMERLENVTGYRLVDKEENYQDTVFIQLALLTKAVFYLDEMEKNGIQPDIAAGHSIGAFCAAVACRSLRFENAAELVYHRAVLMKEAYPSGYAMGVVVGVTRSEAEEIVAKTFDPDHPVYLSNENCPMQHTLSGSIEGLSVTLAEAKRHQAQTAKLLKVPVPSHCLLMNDTVKKFKPYMQSVHLSDARCLYIKNTDGRATQDAEEIRKDLLENLAFPVQWNQMMDLAKELGMDLTIEFPPGNTLTKLIHTKFGVDKGIRTINLDQHGIDDATFLYQKWR
Atome Classification :
(20 SA)
.........10........20........30..---...------.---.-----.40-----.------..------.---------....----.50..---.-----.--------.-------------...-60.-.......70...--.-.-....80-..-..--.-...90........100........110.......120.......-130----.-.-.-......----140.......150..-.....160......-.170.......180.......190-----........200.......210.......220......--.---230.......240.-------------------......250----------------........260.......------270---.........280--.......290.......300.-......310.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
K
I
A
V
E
KVSA
E
E
A
R
L
MST
G
F
LFPGQGSQKL
G
M
---
L
AD------
I
---
P
-----
E
M
------
Y
------
M
E
------
R
---------
L
ENV----TG
Y
R
L---V-----D--------K-------------EEN-YQ
D
-
T
V
F
I
Q
L
A
L
-
L
T
K
--
A
-
V
-
F
Y
L
D
E
M
-
E
K-NG--I-QPDIAAGH
S
I
G
A
F
C
A
-
A
V
A
C
R
S
L
R
F
E
N
A
A
E
L
V
Y
H
R
A
V
L
M
K
EAYP-S------G-
Y
-
A
-
M
G
V
V
V
G----V
T
R
S
E
A
E
E
I
V
A
K
TFD-PDH
P
V
Y
LSNENCPM-QHTLSGSIE
G
L
S
V
T
L
A
E
A
K
R
H
Q
A
------
Q
T
A
K
L
L
KVPVPS
H
C
L
L
MN
D
T
V
K
K
F
K
P
Y
M
Q
SVHLSD
A
R
--
C
---
L
Y
I
KNTDGRATQ
D
A
-------------------
E
E
I
R
K
D
L
L
-----------------
E
NLAFPV
Q
W
N
Q
M
M
D
L
A
K
E------L-----GM
D
L
T
I
E
FPPG
N
--
T
L
T
K
L
I
H
T
KFGVDKG
I
R
T
I
NL-DQHGID
D
A
T
F
L
Y
QKWR
32
HHSearch
85.26
24%
0
- C- -
-
4V8V
-
?
B:
[1343-1958]
-------------
L
A
A
P
K
T
V
Y
A
F
P
G
Q
G
I
Q
H
K
G
M
---
G
M
E
------
V
---
R
-----
A
R
SKAARK
V
------
W
D
------
S
---------
A
D
K
F
TRET
L
G
F
S
V
---
L
-----
H
VVRDN---
P
TSLIASGVHYHHP
D
G
V
-
L
F
L
-
T
Q
F
T
Q
V
A
M
-
A
T
V
--
A
-
A
-
A
Q
V
A
E
M
R
E
--
Q
G
AF
V
-
E
G
A
I
A
C
G
H
S
V
G
E
Y
T
A
L
A
C
V
S
G
V
Y
E
L
E
A
L
L
E
V
V
F
H
R
G
S
K
M
H
D
I
V
P
-
R
DELGRS
N
-
Y
-
R
-
L
A
A
I
R
P
SQID
L
D
D
A
D
V
K
D
F
V
A
E
I
S
E
R
T
G
E
F
L
E
I
V
N
F
N
L
R
G
S
Q
Y
A
I
A
G
T
V
A
G
L
E
A
L
E
E
E
I
E
R
R
R
Q
ITGGKR
S
F
I
L
V
P
G
I
D
V
P
F
H
S
S
V
L
R
V
G
V
A
D
F
R
R
S
L
E
R
V
M
P
R
D
K
D
PE
L
IIG
R
Y
I
P
N
L
V
P
R
P
F
T
L
D
RDFIQEIRDLVPAEPLDEV
L
A
D
Y
D
T
W
R
NEKPKELCRKVVIELLA
W
Q
F
A
S
P
V
R
W
I
E
T
Q
D
L
L
F
I
EEAAGG
L
-----
G
V
E
R
F
V
E
I
G
V
K
S
AP
T
V
A
G
L
A
T
N
T
L
K
L
--------------------------
8
PsiBlast_PDB
78.18
31%
-2
- C1 -
-
2G1H
1
FABD_ECOLI
A:
[5-289]
--------------------
F
V
F
P
G
Q
G
S
Q
T
V
G
M
---
L
A
D
------
M
---
A
-----
A
S
------
Y
P
I
V
E
E
T
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
Y
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
G
A
-
M
A
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
A
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
N
G
-------------------
D
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
9
PsiBlast_PDB
78.13
31%
-2
- C1 -
-
2G2O
-
FABD_ECOLI
A:
[5-289]
--------------------
F
V
F
P
G
Q
G
S
Q
T
V
G
M
---
L
A
D
------
M
---
A
-----
A
S
------
Y
P
I
V
E
E
T
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
Y
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
G
A
-
M
A
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
A
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
N
G
-------------------
D
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
10
PsiBlast_PDB
78.10
31%
-2
- C1 -
-
2G2Y
-
FABD_ECOLI
A:
[5-289]
--------------------
F
V
F
P
G
Q
G
S
Q
T
V
G
M
---
L
A
D
------
M
---
A
-----
A
S
------
Y
P
I
V
E
E
T
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
Y
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
G
A
-
M
A
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
A
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
N
G
-------------------
D
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
15
PsiBlast_PDB
77.36
30%
1
- C1 -
-
3H0P
-
FABD_SALTY
A:
[9-293]
--------------------
F
V
F
P
G
Q
G
S
Q
S
V
G
M
---
L
A
E
M
A
A
N
Y
P
I
---
V
-----
E
E
------
T
------
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
W
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
M
P
A
L
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
N
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
-
G
G
M
S
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
S
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
S
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
D
A
-------------------
A
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
F
I
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
48
Fugue
76.86
27%
7
- C1 -
-
1NM2
2
?
A:
[1-315]
----------------
H
M
L
V
L
V
A
P
G
Q
G
A
Q
T
P
G
F
---
L
T
D
------
W
---
L
A
LPG
A
A
D
------
R
------
V
A
------
A
---------
W
S
D
A
----
I
G
L
D
L
---
A
-----
H
--------
F
G
TKAD--------
A
D
E
-
I
R
D
-
T
S
V
A
Q
P
L
L
-
V
A
A
--
G
-
I
-
L
S
A
A
A
L
-
G
--
T
G
--
F
-
T
P
G
A
V
A
G
H
S
V
G
E
I
T
A
-
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
-
V
------
T
E
T
-
G
-
M
S
A
L
L
G
----
G
D
P
E
V
S
V
A
H
L
E
R
L
------
G
L
T
P
A
N
V
N
G
A
G
-
Q
I
V
A
A
G
T
M
E
Q
L
A
-
A
L
N
E
D
K
P
E
G
V
------
R
K
V
V
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
--
V
---
T
Y
V
S
N
K
D
G
R
A
V
A
S
G
-------------------
T
E
V
L
D
R
L
V
-----------------
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
------
L
-----
G
V
T
A
I
I
E
V
C
P
G
G
--
T
L
T
G
L
A
K
R
A
---
L
P
G
V
K
T
L
A
L
K
T
P
D
D
L
D
A
A
R
E
L
V
A
E
H
T
7
PsiBlast_PDB
76.78
31%
4
- C1 -
-
1MLA
-
FABD_ECOLI
A:
[6-290]
--------------------
F
V
F
P
G
Q
G
S
Q
T
V
G
M
---
L
A
D
------
M
---
A
-----
A
S
------
Y
P
I
V
E
E
T
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
Y
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
G
A
-
M
A
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
A
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
N
G
-------------------
D
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
11
PsiBlast_PDB
75.92
31%
4
- C1 -
-
2G2Z
2
FABD_ECOLI
A:
[5-289]
--------------------
F
V
F
P
G
Q
G
S
Q
T
V
G
M
---
L
A
D
------
M
---
A
-----
A
S
------
Y
P
I
V
E
E
T
F
A
------
E
---------
A
S
A
A
----
L
G
Y
D
L
---
W
A
L
T
Q
Q
G
--------
P
-------------
A
E
E
-
L
N
K
-
T
W
Q
T
Q
P
A
L
-
L
T
A
--
S
-
V
A
L
Y
R
V
W
Q
-
Q
Q
-
G
G
--
K
-
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
-
E
------
G
-
T
G
A
-
M
A
A
I
I
G
----
L
D
D
A
S
I
A
K
A
C
E
E
A
A
E
--
G
Q
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
--
V
---
P
V
V
N
N
V
D
V
K
C
E
T
N
G
-------------------
D
A
I
R
D
A
L
V
-----------------
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
------
Q
-----
G
V
E
H
L
Y
E
V
G
P
G
K
--
V
L
T
G
L
--
T
K
R
I
V
D
-------------------------
17
PsiBlast_PDB
75.22
25%
-
- C1 -
-
3PTW
-
?
A:
[5-296]
-------------------
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
M
---
G
K
E
------
F
---
F
-----
D
N
------
F
------
E
E
S
K
E
V
F
K
R
---------
S
S
E
A
----
L
G
I
D
M
---
E
E
L
C
F
N
D
--------
P
-------------
E
G
L
-
L
N
K
-
T
E
F
T
Q
P
A
I
-
I
T
T
--
N
-
M
-
A
I
L
T
A
L
-
D
K
-
L
G
--
V
-
K
S
H
I
S
C
G
L
S
L
G
E
Y
S
A
-
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
-
E
------
G
-
I
G
G
-
M
V
A
V
L
R
----
M
T
P
E
Q
V
D
E
I
I
E
K
S
-
S
-
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
-
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
V
G
G
------
R
A
I
K
-
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
--
G
---
I
V
M
S
N
V
K
G
E
A
Y
L
E
D
-------------------
D
N
I
I
E
L
L
T
-----------------
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
------
S
-----
G
V
D
T
F
I
E
I
G
P
G
K
--
A
L
S
G
F
V
K
K
---
I
N
K
N
V
T
V
L
N
V
-
E
---------------
1
PsiBlast_PDB
75.07
31%
17
- C1 -
-
3TQE
3
?
A:
[7-289]
-----------------
S
F
A
F
V
F
P
G
Q
G
S
Q
H
L
G
M
---
L
A
E
------
L
G
L
Q
Q
-----
P
I
------
V
------
L
E
------
T
---------
F
Q
Q
A
----
S
S
A
L
A
---
Y
-----
D
L
W
A
L
V
Q
HG
P
-------------
Q
E
R
-
L
D
Q
-
T
Q
F
T
Q
P
A
L
-
L
T
A
--
D
-
V
-
A
I
F
R
C
W
-
E
A
L
G
G
--
P
-
K
P
Q
V
M
A
G
H
S
L
G
E
Y
A
A
-
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
-
V
------
G
-
E
G
A
-
M
G
A
I
I
G
----
L
N
E
A
E
I
E
S
I
-
C
E
N
A
A
-
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
-
Q
T
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
E
G
A
------
K
I
A
K
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
--
V
---
P
V
I
H
N
V
D
V
V
D
H
N
E
A
-------------------
N
I
I
R
G
A
L
I
-----------------
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
E
E
------
Q
-----
G
I
K
V
F
M
E
C
G
P
D
N
--
K
L
A
G
L
I
--------------------------------
13
PsiBlast_PDB
74.48
29%
-6
- C1 -
-
3HJV
5
?
A:
[11-289]
--------------------
I
V
F
P
G
Q
G
S
Q
A
V
G
M
---
L
A
D
------
L
---
A
-----
E
Q
------
Y
A
V
V
K
Q
T
F
A
------
E
---------
A
S
E
V
----
L
G
Y
D
L
---
W
A
L
V
Q
D
G
--------
P
-------------
V
E
D
-
L
N
Q
-
T
F
R
T
Q
P
A
L
-
L
A
A
--
S
-
V
-
A
I
W
R
V
W
-
Q
Q
-
L
G
--
L
E
Q
P
A
V
L
A
G
H
S
L
G
E
Y
S
A
-
L
V
C
A
G
V
I
D
F
K
Q
A
I
K
L
V
E
L
R
G
Q
L
M
Q
Q
A
V
P
-
A
------
G
-
T
-
G
-
A
M
Y
A
I
I
----
G
L
E
D
E
A
I
A
K
A
C
A
D
A
A
-
Q
G
E
V
V
S
P
V
N
F
N
S
P
G
-
Q
V
V
I
A
G
Q
K
D
A
V
E
R
A
G
V
L
C
K
E
A
G
A
------
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
E
L
A
K
T
L
A
E
L
E
F
N
A
P
Q
--
I
---
P
V
I
N
N
V
D
V
V
A
E
T
D
P
-------------------
V
K
I
K
D
A
L
I
-----------------
R
Q
L
Y
S
P
V
R
W
T
E
C
V
E
Q
M
S
A
------
Q
-----
G
V
E
K
L
I
E
-
G
P
G
K
--
V
L
T
G
L
---------------------------------
26
HHSearch
74.40
28%
-7
- C1 -
-
3G87
-
?
A:
[4-290]
---------------
S
M
L
N
T
F
M
F
P
G
Q
G
S
Q
A
K
G
M
---
G
G
A
------
L
---
F
-----
D
R
F
A
D
---
L
------
T
A
------
Q
---------
A
D
A
V
----
L
G
Y
S
I
---
R
A
L
C
V-
D
D-------
P
-------------
R
D
E
-
L
G
R
-
T
Q
F
T
Q
P
A
L
-
Y
V
V
--
N
-
A
L
T
Y
Y
A
K
C
E
D
--
S
G
--
E
-
T
P
D
F
L
A
G
H
S
L
G
E
F
N
A
-
L
L
A
A
G
C
F
D
F
E
T
G
L
K
L
V
A
R
R
A
E
L
M
S
Q
A
R
D
----------
G
-
A
-
M
A
A
I
V
N
----
A
S
R
E
Q
I
E
R
T
L
D
E
H
---
G
L
V
D
T
A
I
A
N
D
N
T
P
S
-
Q
L
V
I
S
G
P
A
H
E
I
A
R
A
E
A
L
F
Q
H
D
R
V
-------
R
Y
L
R
L
N
T
S
G
A
F
H
S
K
F
M
R
P
A
Q
Q
A
F
A
A
H
L
Q
S
F
R
L
A
D
P
A
--
I
---
P
V
I
S
N
V
S
A
R
P
Y
E
N
G
--------------------
R
V
S
E
G
L
A
-----------------
Q
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
L
A
------
L
A
A
E
R
G
E
A
I
E
F
T
E
L
G
H
G
D
--
V
L
T
R
L
V
H
T
I
R
R
Q
--------------------------
3
PsiBlast_PDB
73.86
31%
-2
- C1 -
-
3K89
1
?
A:
[8-287]
--------------------
F
V
F
P
G
Q
G
S
Q
S
L
G
M
---
L
A
E
------
L
---
S
-----
E
L
------
H
P
Q
I
---
R
E
------
T
---------
F
A
E
A
----
S
E
G
A
G
---
V
-----
D
L
W
A
L
S
Q
GG
P
-------------
E
E
M
-
L
N
R
-
T
E
Y
T
Q
P
A
L
-
L
A
A
G
V
A
-
V
-
W
R
L
W
T
A
-
Q
R
--
G
--
Q
-
R
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
-
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
-
A
------
G
-
V
G
A
-
M
A
A
V
L
G
----
A
E
D
A
V
V
L
E
V
C
A
E
A
A
G
--
S
Q
V
V
V
P
A
N
F
N
S
P
G
-
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
V
------
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
--
I
---
P
V
V
Q
N
V
D
A
R
V
H
D
G
S
-------------------
A
A
I
R
Q
A
L
V
-----------------
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
------
Q
-----
G
I
T
R
I
A
E
C
G
P
G
K
--
V
L
S
G
L
I
--------------------------------
40
HHSearch
73.47
26%
-
- C1 -
-
3PTW
-
?
A:
[3-289]
-----------------
K
L
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
M
---
G
K
E
------
F
---
F
-----
D
N
F
E
E
S
K
E
V
------
F
K
------
R
---------
S
S
E
A
----
L
G
I
D
M
---
E
-----
E
L
C
F
ND---
P
-------------
E
G
L
-
L
N
K
-
T
E
F
T
Q
P
A
I
-
I
T
T
--
N
-
M
-
A
I
L
T
A
L
D
K
--
L
G
--
V
-
K
S
H
I
S
C
G
L
S
L
G
E
Y
S
A
-
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
E
G
------
I
-
G
-
G
-
M
V
A
V
L
R
----
M
T
P
E
Q
V
D
E
I
I
E
K
S
S
--
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
-
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
V
G
G
-------
R
A
I
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
--
G
---
I
V
M
S
N
V
K
G
E
A
Y
L
E
D
-------------------
D
N
I
I
E
L
L
T
-----------------
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
------
S
-----
G
V
D
T
F
I
E
I
G
P
G
K
--
A
L
S
G
F
V
K
K
I
N
K
N
--------------------------
19
PsiBlast_PDB
73.37
28%
-
- C- -
-
3RGI
-
?
A:
[4-273]
--------------------
Y
M
F
P
G
Q
G
S
Q
A
K
G
M
G
R
A
L
F
D
------
A
---
F
-----
P
A
------
L
------
T
A
------
R
---------
A
D
G
V
----
L
G
Y
S
I
---
R
A
L
C
Q
D
D
--------
P
-------------
D
Q
R
-
L
S
Q
-
T
Q
F
T
Q
P
A
L
Y
V
V
N
--
A
-
L
-
S
Y
L
K
R
R
-
E
E
-
E
A
----
P
P
D
F
L
A
G
H
S
L
G
E
F
S
A
-
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
G
D
A
---
R
------
G
-
G
-
G
-
M
A
A
V
I
G
----
L
D
E
E
R
V
R
E
L
L
D
Q
--
N
-
G
A
T
A
V
D
I
A
N
L
N
S
P
S
-
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
A
A
G
A
------
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
G
Y
D
F
A
P
P
K
--
I
---
P
V
I
S
N
V
T
A
R
P
C
K
-
A
-------------------
D
G
I
R
A
A
L
S
-----------------
E
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
------
R
-----
G
V
E
E
F
V
E
C
G
H
G
I
--
V
L
T
G
L
---------------------------------
43
HHSearch
72.95
28%
19
* C1 *
-
3IM9
-
FABD_STAAM
A:
[3-297]
---------
S
G
L
V
P
R
G
S
H
M
A
I
I
F
P
G
Q
G
A
Q
K
V
G
M
---
A
Q
D
------
L
---
F
-----
N
N
N
D
----
Q
A
T
E
I
--
L
T
------
S
---------
A
A
K
T
----
L
D
F
D
I
---
L
-----
E
T
M
F
TD---
E
-------------
E
G
K
-
L
G
E
-
T
E
N
T
Q
P
A
L
-
L
T
H
--
S
-
S
-
A
L
L
A
A
L
-
K
---
N
--
L
-
N
P
D
F
T
M
G
H
S
L
G
E
Y
S
S
-
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
-
T
G-----
V
-
G
-
S
-
M
A
A
V
L
G
----
L
D
F
D
K
V
D
E
I
C
K
S
L
S
S
-
D
D
K
I
I
E
P
A
N
I
N
C
P
G
-
Q
I
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
L
G
A
------
K
R
V
M
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
--
F
---
P
V
V
Q
N
V
N
A
Q
G
E
T
D
K
-------------------
E
V
I
K
S
N
M
V
-----------------
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
------
Q
-----
G
V
D
H
F
I
E
I
G
P
G
K
--
V
L
S
G
L
I
K
K
I
N
R
D
--------------------------
4
PsiBlast_PDB
72.54
31%
-1
- C1 -
-
3R97
1
?
A:
[8-287]
--------------------
F
V
F
P
G
Q
G
S
Q
S
L
G
M
---
L
A
E
------
L
---
S
-----
E
L
------
H
P
Q
I
---
R
E
------
T
---------
F
A
E
A
----
S
E
G
A
G
---
V
-----
D
L
W
A
L
S
Q
GG
P
-------------
E
E
M
-
L
N
R
-
T
E
Y
T
Q
P
A
L
-
L
A
A
G
V
A
-
V
-
W
R
L
W
T
A
-
Q
R
--
G
--
Q
-
R
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
-
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
-
A
------
G
-
V
G
A
-
M
A
A
V
L
G
----
A
E
D
A
V
V
L
E
V
C
A
E
A
A
G
--
S
Q
V
V
V
P
A
N
F
N
S
P
G
-
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
V
------
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
--
I
---
P
V
V
Q
N
V
D
A
R
V
H
D
G
S
-------------------
A
A
I
R
Q
A
L
V
-----------------
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
------
Q
-----
G
I
T
R
I
A
E
C
G
P
G
K
--
V
L
S
G
L
I
--------------------------------
20
PsiBlast_PDB
71.42
28%
-1
- C1 -
-
3SBM
1
?
A:
[4-273]
--------------------
Y
M
F
P
G
Q
G
S
Q
A
K
G
M
G
R
A
L
F
D
------
A
---
F
-----
P
A
------
L
------
T
A
------
R
---------
A
D
G
V
----
L
G
Y
S
I
---
R
A
L
C
Q
D
D
--------
P
-------------
D
Q
R
-
L
S
Q
-
T
Q
F
T
Q
P
A
L
Y
V
V
N
--
A
-
L
-
S
Y
L
K
R
R
-
E
E
-
E
A
----
P
P
D
F
L
A
G
H
S
L
G
E
F
S
A
-
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
G
D
A
---
R
------
G
-
G
-
G
-
M
A
A
V
I
G
----
L
D
E
E
R
V
R
E
L
L
D
Q
--
N
-
G
A
T
A
V
D
I
A
N
L
N
S
P
S
-
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
A
A
G
A
------
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
G
Y
D
F
A
P
P
K
--
I
---
P
V
I
S
N
V
T
A
R
P
C
K
-
A
-------------------
D
G
I
R
A
A
L
S
-----------------
E
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
------
R
-----
G
V
E
E
F
V
E
C
G
H
G
I
--
V
L
T
G
L
---------------------------------
6
PsiBlast_PDB
71.42
30%
5
- C1 -
-
3IM8
-
?
A:
[3-282]
-----------------
K
T
A
F
L
F
A
G
Q
G
A
Q
Y
L
G
M
---
G
R
D
------
F
---
Y
-----
D
Q
------
Y
P
I
V
K
E
T
I
D
------
R
---------
A
S
Q
V
----
L
G
Y
D
L
R
Y
L
I
-----
D
--------
T
-------------
E
E
D
K
L
N
Q
-
T
R
Y
T
Q
P
A
I
-
L
A
T
--
S
-
V
-
A
I
Y
R
L
L
-
Q
E
-
K
G
--
Y
-
Q
P
D
M
V
A
G
L
S
L
G
E
Y
S
A
-
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
-
A
------
D
-
S
-
G
-
K
M
V
A
V
L
----
N
T
P
V
E
V
I
E
E
A
C
Q
K
A
S
-
E
L
G
V
V
T
P
A
N
Y
N
T
P
A
-
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
A
G
A
------
K
R
L
I
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
Q
V
S
F
S
D
F
T
--
C
---
P
L
V
G
N
T
E
A
A
V
M
Q
K
--------------------
E
D
I
A
Q
L
L
T
-----------------
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
------
A
-----
G
I
S
N
F
I
E
I
G
P
G
K
--
V
L
S
G
F
V
--------------------------------
12
PsiBlast_PDB
70.80
28%
-15
- C- -
-
3EZO
-
?
A:
[0-281]
----------------
M
K
F
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
---
L
N
A
------
F
---
A
-----
D
V
------
A
------
V
V
------
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
----
I
G
K
L
I
---
A
-----
D
--------
G
-------------
P
A
D
-
E
L
N
L
T
T
N
T
Q
P
V
M
-
L
T
A
--
A
Y
A
-
C
Y
R
A
W
Q
-
Q
A
-
G
G
--
A
-
Q
P
S
I
V
A
G
H
S
L
G
E
Y
T
A
-
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
-
V
------
G
-
V
-
G
G
M
A
A
I
L
G
----
L
D
D
D
T
V
R
A
V
C
A
E
A
-
S
-
A
T
G
V
V
E
A
V
N
F
N
A
P
A
-
Q
V
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
K
G
A
------
K
R
A
L
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
--
I
---
S
V
V
N
N
I
D
V
A
V
V
S
D
P
-------------------
A
A
I
K
D
A
L
V
-----------------
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
A
R
------
E
-----
G
V
T
H
V
I
E
C
G
P
G
K
--
V
L
A
G
L
---------------------------------