@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1D9: (2017-12-20 )
MINLVKPLLPGSTIGIVGGGQLGRMMAISAKEMGFKVGVLDPVSDCPAAQVADWHIESVYDDTFALKELARRTDVITYEFENVSVEALNAILPMSFIPQGTDLLAITQDRLLEKSFLETNNIVIAPYATIVSPTDIQDAIDGIGYPCVLKTTRGGYDGKGQYVLKSRADLAPAMDLLREGTCVLEAWIPFEKEISIMVAGNGQGDFTTFPVVENIHHNNILHETIAPAAIDQDVIEEAERIARVIAEAVSLSGVLGVEMFLTKTGGLYVNELAPRPHNSGHYSIEACSMSQFDAHIRGICGWPLGEKVRLISNAVMVNVLGEQLLESYRLIENKPDWQFHFYGKKQAKKGRKMGHITILTEDIQQTLEEIKQTNIWD
Atome Classification :
(27 SA)
.........10........20........30........40......---..50........60........70........80......---..90..--......100.......110.......120.......130.....---..140..---.....150-...-.-...160.......170......--.180-........190.-.......200--.......210.......220......-.-230....--.-...240.......250.......260.......270.......280.......290.......300.......310.......320-.----------....------...330..----.....340.......350.......360.......370.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MINLVKPLLPG
S
T
I
G
I
VGGGQL
G
R
M
M
A
I
SAKEM
G
F
K
V
GVLDPVSDCP---A
A
Q
VA
D
W
H
I
E
S
VYD
D
T
F
A
L
K
E
L
ARRT
D
V
I
T
Y
E
FENV
S
V
E
A
---
L
N
A
ILP--MSFIPQG
T
D
L
L
A
I
T
Q
D
R
L
L
E
K
S
FLETN
N
I
V
I
APYATIV
S
P
T
D
I
Q
---
D
A
I
DGIG---Y
P
C
V
L
KTT-RGG-Y-DGKG
Q
Y
V
L
KSRAD
L
A
P
A
M
D
L
L
R--EG
T
--
C
V
L
E
AWIPFE-
K
-
E
I
S
I
M
V
A
GNG--QGD
F
T
T
F
P
V
V
E
NIHHN
N
I
L
H
E
TIAPA-A-I
D
-
Q
D
V
I
--
E
-
E
A
E
R
I
A
R
V
I
A
E
A
V
S
L
S
G
V
L
G
V
E
M
F
L
TKTG
G
L
Y
V
N
ELAPRPHNSG
H
Y
S
I
E
ACS
M
S
Q
F
D
A
H
I
R
G
I
CGWPL
G
E
K
V
R
L
I
S
N
A
V
M
V
N
V
L
G
--
E
----------
Q
L
L
E
------
S
Y
R
L
IENK----PD
W
Q
F
H
F
YG
K
K
Q
A
KKGRKMG
H
I
T
I
L
T
E
D
I
Q
Q
T
L
E
E
I
K
QTNIWD
2
PsiBlast_PDB
89.60
49%
-115
- C1 -
-
3QFF
1
?
A:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
5
PsiBlast_PDB
88.88
49%
-114
- C1 -
-
4DLK
3
?
A:
[1-373]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
4
PsiBlast_PDB
88.42
49%
-109
- C1 -
-
3V4S
1
?
A:
[8-379]
----
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
3
PsiBlast_PDB
88.34
49%
-112
- C1 -
-
3R5H
2
?
A:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
1
PsiBlast_PDB
88.17
49%
-110
- C1 -
-
3Q2O
-
?
A:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
21
PsiBlast_CBE
88.15
49%
-109
- C1 -
-
3R5H
2
?
B:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
24
PsiBlast_CBE
88.05
49%
-111
- C1 -
-
3V4S
1
?
B:
[6-379]
--
D
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
25
PsiBlast_CBE
87.97
49%
-111
- C1 -
-
4DLK
1
?
B:
[1-373]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
22
PsiBlast_CBE
87.97
49%
-113
- C1 -
-
3QFF
1
?
B:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
-
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
-
T
N
L
L
K
P
V
V
M
V
N
I
L
G
--
E
----------
H
I
E
G
------
V
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
59
HHSearch
84.98
49%
-49
- C1 -
-
3Q2O
-
?
B:
[7-379]
---
M
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
-
G
-
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
-
F
E
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
N
L
L
-
K
P
V
V
M
V
N
I
L
G
EH
I
----------
E
G
V
--------
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
60
HHSearch
84.23
49%
-46
- C1 -
-
4DLK
1
?
B:
[3-373]
-----
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
---
L
Q
W
L
E
K
--
H
A
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
-
G
-
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
--
A
A
E
--
C
I
L
E
K
W
V
P
-
F
E
K
-
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
-
R
-
I
T
-
E
E
L
S
--
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
N
L
L
-
K
P
V
V
M
V
N
I
L
G
EH
I
----------
E
G
V
--------
L
R
Q
V
N
R
L
----
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
8
PsiBlast_PDB
80.10
39%
-49
- C1 -
-
4E4T
-
?
A:
[29-398]
----
V
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
---
A
G
A
V
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
---
L
D
F
L
A
R
--
T
T
F
V
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
---
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
L
G
-
Y
-
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
--
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
-
E
V
S
A
L
I
A
R
G
A
--
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
A
-
A
D
-
T
A
R
V
--
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
Q
H
S
P
A
A
M
L
N
I
L
G
--
D
VWFPNGAAA
G
A
V
T
P
------
P
W
D
T
V
A
A
M
----
P
A
A
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
N
F
T
A
E
----------------
61
HHSearch
79.01
44%
-15
- C1 -
-
3ORQ
2
?
A:
[7-372]
-----
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
---
C
R
Y
V
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
---
L
K
L
L
C
E
K
Y
N
I
P
--
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
-
G
G
Y
-
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
--
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
-
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
-
R
-
I
D
---
K
T
--
A
-
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
G
--
K
----------
D
L
D
L
------
L
E
N
E
F
N
E
H
----
P
E
W
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
----
6
PsiBlast_PDB
78.28
44%
-88
- C1 -
-
3ORQ
2
?
A:
[12-365]
----------
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
---
C
R
Y
V
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
---
L
K
L
L
C
E
--
K
Y
N
I
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
-
Y
-
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
--
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
-
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
-
R
-
I
D
-
K
-
T
A
--
E
-
A
K
E
Q
V
N
K
I
I
-
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
G
--
K
----------
D
L
----------
D
L
L
E
N
E
FNEH
P
E
W
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
-----------
7
PsiBlast_PDB
76.76
44%
-87
- C1 -
-
3ORR
-
?
A:
[9-362]
----------
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
---
C
R
Y
V
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
---
L
K
L
L
C
E
--
K
Y
N
I
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
-------
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
--
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
-
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
-
R
-
I
D
-
K
-
T
A
--
E
-
A
K
E
Q
V
N
K
I
I
-
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
G
--
K
----------
D
L
----------
D
L
L
E
N
E
FNEH
P
E
W
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
-----------
63
HHSearch
76.09
39%
-28
- C1 -
-
4E4T
-
?
A:
[30-409]
-----
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
---
A
G
A
V
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
---
L
D
F
L
A
R
T-
T
F
V
-
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
A
LD
D
A
A
L
D
A
V
---
L
P
G
I
L
K
T
A
R
L
-
G
-
Y
-
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
--
G
V
P
--
C
V
L
E
K
R
L
P
-
L
---
K
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
-
P
-
A
A
D
T
A
R
V
--
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
R
Q
H
-
S
P
A
A
M
L
N
I
L
G
--
D
VWFP------
N
G
A
A
A
G
A
V
T
P
P
W
D
T
V
A
A
M
----
P
A
A
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
N
F
T
A
E
M
R
D
D
A
V
A
A
A
T
A
-----
62
HHSearch
74.67
39%
-27
- C1 -
-
4E4T
-
?
B:
[30-409]
-----
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
---
A
G
A
V
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
---
L
D
F
L
A
R
T
-
T
F
V
-
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
A
LD
D
A
A
L
D
A
V
---
L
P
G
I
L
K
T
A
R--------
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
--
G
V
P
--
C
V
L
E
K
R
L
P
-
L
---
K
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
-
P
-
A
A
D
T
A
R
V
--
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
R
Q
H
-
S
P
A
A
M
L
N
I
L
G
--
D
VWFP------
N
G
A
A
A
G
A
V
T
P
P
W
D
T
V
A
A
M
----
P
A
A
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
N
F
T
A
E
M
R
D
D
A
V
A
A
A
T
A
-----
72
HHSearch
73.82
42%
-25
- C1 -
-
3AX6
1
?
C:
[1-363]
----------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
---
A
G
Q
V
A
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
---
L
K
K
L
Y
N
E-
G
Y
K
I
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
S
------
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
-
G
------
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
K
------
G
E
--
T
Y
L
E
E
F
V
E
I
E
-
K
-
E
L
A
V
M
V
A
R
N
E
--
K
G
E
I
A
C
Y
P
V
V
E
M
Y
-------
T
V
I
A
P
A
-
R
-
I
E
-
E
K
Y
S
--
K
-
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
S
T
E
L
L
-
I
P
A
V
M
V
N
L
L
G
--
E
----------
E
G
Y
Y
GKPALI
G
L
E
E
A
L
A
I
----
E
G
L
S
L
H
F
Y
G
K
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
D
V
E
R
A
L
E
K
A
L
R
-----
71
HHSearch
73.39
42%
-25
- C1 -
-
3AX6
1
?
A:
[1-363]
----------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
---
A
G
Q
V
A
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
---
L
K
K
L
Y
N
E
-
G
Y
K
I
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
S
------
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
-
G
------
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
K
------
G
E
--
T
Y
L
E
E
F
V
E
I
E
-
K
-
E
L
A
V
M
V
A
R
N
E
--
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
T
V
I
A
P
A
-
R
-
I
E
-
E
K
Y
S
--
K
-
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
S
T
E
L
L
-
I
P
A
V
M
V
N
L
L
G
--
E
----------
E
G
Y
Y
G
K
P
A
L
I
G
L
E
E
A
L
A
I
----
E
G
L
S
L
H
F
Y
G
K
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
D
V
E
R
A
L
E
K
A
L
R
-----
66
HHSearch
71.18
35%
-82
- C1 -
-
3AW8
1
?
A:
[1-357]
------------
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
-
G
E
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
---
A
R
R
L
E
G
--
R
L
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
-
G
-------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
--
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
-
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
-
P
G
A
S
-
E
A
L
Q
--
K
-
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
A
P
R
-
G
Q
S
A
M
V
N
L
I
G
--
E
----------
K
P
P
--------
F
A
E
V
L
K
V
----
E
G
A
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
L
A
R
L
S
---
67
HHSearch
69.23
34%
-46
- C1 -
-
4MAM
3
?
A:
[1-354]
-----------
M
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
---
E
-
E
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
---
I
K
A
I
N
H
--
E
V
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
-
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
DA
P
D
G
--
L
I
Y
E
A
F
V
D
-
F
-
D
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
---
E
N
-
V
V
L
A
--
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
-
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
T
S
--
R
K
T
V
M
L
N
C
I
G
--
G
----------
M
P
A
--------
T
K
D
L
A
A
L
----
D
R
V
K
I
H
S
Y
N
K
E
-
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
T
D
E
-
Y
Q
L
L
Q
-----
14
PsiBlast_PDB
66.95
34%
7
- C1 -
-
4MAM
3
?
A:
[3-345]
-------------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
D
I
E
L
T
K
V
N
D
----
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
---
I
K
A
I
N
H
--
E
V
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
-
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
--
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
-
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
------
E
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
T
S
--
R
K
T
V
M
L
N
C
I
G
--
G
----------
M
--
P
------
A
T
K
D
L
A
A
L
----
D
R
V
K
I
H
S
Y
N
-
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
---------------
11
PsiBlast_PDB
66.35
34%
6
- C1 -
-
5JQW
1
?
A:
[6-348]
-------------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
D
I
E
L
T
K
V
N
D
----
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
---
I
K
A
I
N
H
--
E
V
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
-
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
--
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
-
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
------
E
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
T
S
--
R
K
T
V
M
L
N
C
I
G
--
G
----------
M
--
P
------
A
T
K
D
L
A
A
L
----
D
R
V
K
I
H
S
Y
N
-
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
---------------
13
PsiBlast_PDB
66.09
34%
4
- C1 -
-
4MA0
3
?
A:
[3-345]
-------------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
D
I
E
L
T
K
V
N
D
----
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
---
I
K
A
I
N
H
--
E
V
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
-
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
--
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
-
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
------
E
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
T
S
--
R
K
T
V
M
L
N
C
I
G
--
G
----------
M
--
P
------
A
T
K
D
L
A
A
L
----
D
R
V
K
I
H
S
Y
N
-
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
---------------
27
PsiBlast_CBE
65.99
36%
-11
- C1 -
-
3AW8
1
?
B:
[12-351]
-----------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
G
E
L
V
V
G
E
F
L
D
E
G
-
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
ARR
L
E
G
R
L
P
--
L
-
Y
P
P
--
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
--------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
--
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
-
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
-
P
-
G
A
-
S
E
A
L
--
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
E
L
L
F
-
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
A
P
R
G
Q
S
A
-
M
V
N
L
I
G
--
E
----------
K
--
P
------
P
F
A
E
V
L
K
V
----
E
G
A
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
-
L
R
R
D
G
L
K
A
L
E
E
--------
10
PsiBlast_PDB
65.58
36%
-14
- C1 -
-
3AW8
1
?
A:
[12-351]
-----------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
G
E
L
V
V
G
E
F
L
D
E
G
-
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
R
L
P
--
L
-
Y
P
P
--
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
--------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
--
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
-
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
-
P
-
G
A
-
S
E
A
L
--
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
E
L
L
F
-
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
A
P
R
G
Q
S
A
-
M
V
N
L
I
G
--
E
----------
K
--
P
------
P
F
A
E
V
L
K
V
----
E
G
A
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
-
L
R
R
D
G
L
K
A
L
E
E
--------
12
PsiBlast_PDB
64.27
34%
3
- C1 -
-
4MA5
3
?
A:
[3-345]
-------------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
D
I
E
L
T
K
V
N
D
----
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
---
I
K
A
I
N
H
--
E
V
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
-
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
--
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
-
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
------
E
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
--
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
T
S
--
R
K
T
V
M
L
N
C
I
G
--
G
----------
M
--
P
------
A
T
K
D
L
A
A
L
----
D
R
V
K
I
H
S
Y
N
-
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
---------------