@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U1V9: (2017-12-21 )
MTAKDEYFLETSSSKRIIVCLLDVFVSISTIRYLFFIARCENMFHNREVRKKLSNGGQKMKTVILAEKPSQAKAYAETFQQQKRHEGYYEISDPLFAGEVTITYGFGHLVDMVAPGAYEERWAKWSLENLPIFPETFRYEVPMDKRAQFSIVKRELQSADTIIIATDGDREGEAIAWSIIRQANAFSKEKNYLRLWINSLEKEAIYEGFKNLQPGKNYFPKYKEAQARQNADWLIGMNGSPLYSLLLQRKGIDGSFSLGRVQTPTLYMIYQLQEEIKHFKKETYFEGEGLITTNKGQFSGKIVPKKAFKTQEELTKEIEKLGAHLGKQNGRILEVTKKEKRLHSPRLFSLSSLQTKMNQLMKASAKATLDAAQGLYESKFLSYPRTDSFYITENEHQYLVKHLQNYKKFLGIEEVQTTEIKAKKRYVDAKKVQEHHAIIPTKTIPTPARFAKLSKLQQAIYLQVLRTTVAMFAADYIYEETTVMTGVQQLKLKSIGKIPLQQGWQEILRIKSKKKEAQTLPPIVENEEAEVELKSMEKETQPPKPYTEGTLITAMKTAGKTLDNDEAQEILKEVEGIGTEATRANIIENLKQKHYIEVNKNEITVTPKGITLCKAVANEPLLTSAEMTARWEGYLRKIGKQEGTPSVFLENIKKFILHLLAEVPNQIDKVDFSDEISGTRQIKAMEKKNDQLGRCPKCKKGIVMLYPKIATCLNPECDFKLWPTVAKKKLTKTNLRDLLSKGKTSKVVKGFTGKKGKFDAVLVLKEDMTIGFSFPWIENSGTKAVDGNKETSRKNNENEVE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........--80.--...---..------..90.-..-....---.100....--...110.......120..--..-------.-...130..-.....140--..--..---...----150.......160.......170.......180..-..-----...190.......200.......210.......220.......230.......240.......---250---.---....-...260.......270.......280.......-290....-------.--..300..----------------------.--....310........320...----.....330.......340.......350.......360.......370......--------.380.......390....----...400....--..--.410..-...-.-.-420.......430..-.....440..---....--.-450.......460.......470.......480.....----..490.......--500.......510..-------..--...520.......530-..-......540.......550.......560.......570.......580.......590.......-600-.......-610......-.-620.......630.......640.......650.......660.......670--.-.......-680.......690.......700...---....710...------.-...720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTAK
D
E
Y
F
L
ETSSS
K
R
I
I
V
C
L
L
D
V
F
V
S
I
S
T
I
R
Y
L
F
F
I
A
R
C
E
N
M
F
H
N
R
E
V
R
K
K
L
SNGG
Q
K
M
K
T
V
I
L
AEKP
S
Q
A
K
A
Y
A
E
T
F
--
Q
Q
Q
--
K
R
H---EG------
Y
Y
EIS-DP-LFA
G
---
E
V
T
I
T
YGF--
G
H
L
V
D
M
VAP
G
A
Y
E
E
-
R
W
A--KW-------S-LENLPIFP-E
T
F
R
YEVP--MD--K
R
---
A
Q
F
----
S
I
V
K
R
E
LQSA
D
T
I
I
I
A
TDGDREG
E
A
I
A
W
S
I
I
R
Q
A
N-AF-----SKE
K
N
Y
L
R
L
W
I
N
SL
E
K
E
A
I
Y
E
G
F
K
NLQPGKNYFPK
Y
K
E
A
Q
ARQNA
D
W
L
I
GMNG
S
P
L
Y
S
L
L
L
Q
R---KG----I---DGSF-SLGRVQTP
T
L
Y
M
I
Y
Q
L
Q
E
E
I
K
H
F
K
K
ETYFEGE
G
-
L
I
TTNKG-------Q--FS
G
K
IV
P
----------------------
K
--
K
AFK
T
-
Q
E
E
L
T
K
E
I
E
K
-
L
G
A
H
----LGKQN
G
R
I
L
E
V
T
K
K
E
KRLHSPRL
F
S
L
S
S
L
Q
T
K
M
N
Q
L
M
K
A
S
A
K
A
T
L
D
A
A
Q
G
L
Y
E
S
--------
K
FLSYPRTD
S
F
Y
I
TEN
E
H
----
Q
Y
L
V
K
H
L
Q
N
Y
--
K
K
--FLGIEE-VQT-T-
E
-
I
K
A
K
K
RYV
D
A
K
K
V
Q
E
-
H
HAIIPTKTI---P
T
P
A
--
R
-
F
A
K
L
S
K
L
Q
Q
A
I
Y
L
Q
V
L
R
T
T
V
A
M
F
A
A
D
Y
I
YE
E
T
T
V
M
T
G
V
----
Q
Q
L
K
L
K
SIGK
I
P
--
L
Q
Q
G
W
Q
E
I
L
R
I
K
S
KK-------KE--AQTLPPIVENE
E
A
E
-
V
-
E
L
-
K
S
M
EKETQPPKPYTEG
T
L
I
T
A
M
K
TAGKTLD
N
D
E
A
Q
E
I
L
K
E
V
EGIGT
E
A
T
R
A
N
I
I
E
N
L
K
QK
H
Y
I
E
V
N-K
N
E
-
I
T
VTPK
G
-
I
T
L
C
K
A
V
AN-E-PLLT
S
A
E
M
T
A
R
W
E
G
Y
L
R
K
IGKQEG
T
P
S
V
F
L
E
N
I
K
K
F
I
L
H
L
L
A
EVPNQIDKV-D--F-SDEISGT-
R
Q
I
K
A
M
E
KKNDQLGRCPKCKK
G
I
V
M
L---Y
P
K
I
A
T
CLNP------E-CD
F
K
LW
P
T
V
A
K
K
KL
T
K
T
N
L
R
D
L
L
SKGK
T
S
K
V
V
KGFTGKKGK
F
D
A
V
L
V
L
KED
M
T
I
GFSFPWIENSGTKAVDGNKETSRKNNENEVE
6
PsiBlast_PDB
100.00
29%
0
- C- -
-
2O5E
1
TOP3_ECOLI
A:
[3-628]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
100.00
29%
0
- C- -
-
2O5C
1
TOP3_ECOLI
A:
[3-628]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
100.00
29%
0
- C- -
-
2O54
1
TOP3_ECOLI
A:
[3-631]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
100.00
29%
0
- C- -
-
2O19
1
TOP3_ECOLI
A:
[3-631]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
98.16
29%
0
- C- -
-
2O59
1
TOP3_ECOLI
A:
[3-635]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
----
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
------------ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
96.70
28%
0
- C- -
-
2O5E
1
TOP3_ECOLI
A:
[1-633]
------------------------------------------------------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
H
-
R
K
G
---
D
G
------
F
I
E
C
G
-
N
---------
G
Q
V
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
-
L
A
P
----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
-
H
I
V
T
P
A
D
E
------
R
--
F
T
A
I
W
Q
P
SEACEPYQDE------------
E
--
G
R
L
L
H
-
R
P
L
A
E
H
V
V
N
R
-
I
-------
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
----
A
G
R
H
A
V
M
N
A
I
--
S
V
--
H
A
P
D
L
L
P
Q
P
V
-
V
-
D
-
P
D
I
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
A
-------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
EE-----
N
D
--
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
-
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
-
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.41
28%
36
- C2 -
-
1I7D
1
TOP3_ECOLI
A:
[1-608]
------------------------------------------------------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
H
-
R
K
G
---
D
G
------
F
I
E
C
G
-
N
---------
G
Q
V
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
-
L
A
P
----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
-
H
I
V
T
P
A
D
E
------
R
--
F
T
A
I
W
Q
P
S
EACEPYQDE------------
E
--
G
R
L
L
H
-
R
P
L
A
E
H
V
V
N
R
-
I
-------
S
G
-
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
----
A
G
R
H
A
V
M
N
A
I
--
S
V
--
H
A
P
D
L
L
P
Q
P
V
-
V
-
D
-
P
D
I
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
S
---
S
A
-------
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
EE-----
N
D
--
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
E
K
G
-
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
-
M
---
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.36
28%
35
- C2 -
-
1I7D
1
TOP3_ECOLI
A:
[3-603]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
---
A
G
----
Y
---
Q
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.27
29%
38
- C2 -
-
1D6M
-
TOP3_ECOLI
A:
[3-603]
--------------------------------------------------------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
--
H
R
K
G
--
D
G
------
F
I
E
C
G
-
N
-----
G
---
Q
V
-
V
T
W
C
I
--
G
H
L
L
E
Q
A
Q
P
D
A
Y
D
S
-
R
Y
A
--
R
W
-------
N
-
L
A
D
L
P
I
V
P
-
E
K
W
Q
L
Q
P
R
--
P
S
--
V
T
---
K
Q
L
----
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
-----
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
----------------
G
V
L
-
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
-------
R
--
F
T
A
I
W
Q
P
----------------------
S
--
E
A
C
E
P
Y
Q
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
H-------
K
L
I
T
Y
P
R
S
D
C
R
Y
L
P
E
-
E
H
FAG
R
H
A
V
M
N
A
I
S
V
H
--
A
P
--
D
L
L
P
Q
P
-
V
V
D
-
P
-
D
-
I
--
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
R
-------
S
--
S
-
A
I
N
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
----
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
G
W
R
T
L
L
G
S
K
E
R
D
-------
E
E
ND
G
T
P
L
P
V
V
A
K
G
D
E
L
L
-
C
-
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
-
I
H
S
T
D
A
G
-
K
A
L
F
H
S
L
P
E
----
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
63.27
23%
26
- C2 -
-
4CGY
-
TOP3A_HUMAN
A:
[22-640]
--------------------------------------------
F
S
R
A
A
M
E
M
A
L
R
G
V
R
--
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
G
R
M
--
R
R
R
---
E
G
LSKF
N
K
I
Y
E
F
D
-
Y
H
-
L
Y
G
Q
---
N
V
T
M
V
M
T
S
V
S
G
H
L
L
----
A
H
D
F
Q
M
-
Q
F
R
--
K
W
-------
Q
S
C
N
P
L
V
L
F
E
-
A
E
I
E
K
Y
C
P
--
E
N
--
F
V
---
D
I
K
----
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
-
A
V
-----
K
P
N
L
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
--
Q
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
I
F
P
E
V
----
L
---
A
E
Q
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
V
-
T
H
D
H
K
D
G
-------
I
--
V
E
F
N
W
K
R
----------------------
H
--
R
L
F
-
N
-
H
T
A
C
L
V
L
Y
Q
L
-
C
V
E
-------
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
----
L
T
V
L
V
E
Q
Q
T
P
--
D
P
--
R
W
G
A
F
A
-
Q
S
I
-
L
-
E
-
R
G
G
P
T
P
R
N
G
N
K
S
D
Q
A
-
H
P
P
I
H
P
T
K
Y
T
---
N
N
---------
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
N
Y
L
D
V
Y
--
P
Y
D
H
-------
W
S
--
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
-
P
S
T
V
-
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
K
H
G
-----------------
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
-
P
D
K
R
F
L
P
G
H
L
G
-
M
G
L
V
E
G
Y
D
S
M
G
-
Y
E
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
----------------------------------------------------------------------------
K
A
K
K
L
D
E
A
L
A
Q
Y
F
G
N
G
T
----------------------------------------------------------
34
HHSearch
62.26
23%
17
- C2 -
-
4CGY
-
TOP3A_HUMAN
A:
[22-640]
-------------------------------------------
F
S
-
R
A
A
M
E
--
M
A
L
R
G
V
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
--
S
N
G
R
M
R
R
R
---
E
G
LSKF
N
K
I
Y
E
F
D
-
Y
H
L
Y
G
Q
N
V
--
T
M
V
M
T
S
V
S
--
G
H
L
L
A
H
D
F
Q
M
Q
F
-----
R
--
K
W
-------
Q
--
S
C
N
P
L
V
---
L
F
E
A
E
I
E
--
K
Y
--
C
P
---
E
N
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
-
A
V
-----
K
P
N
L
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
Q
--
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
---
I
F
PEVL
A
---
E
Q
L
I
-
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
V
-
T
H
D
H
K
D
G
-------
I
--
V
E
F
N
W
K
R
-------------------------
H
R
L
F
N
-
H
T
A
C
L
V
L
Y
Q
L
-
C
--
V
----
E
D
-
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
----
L
T
V
L
--
V
E
Q
Q
--
T
P
DP
R
W
G
A
-
F
-
A
Q
S
I
L
-
E
R
G
G
P
T
P
R
N
-
G
N
K
S
D
Q
A
-
H
P
P
I
H
P
T
K
Y
T
---
N
---------
N
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
----
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
N
Y
L
D
V
Y
P
Y
D
H
W
---------
S
--
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
-
P
S
T
V
-
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
-----------------
K
H
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
-
F
L
P
G
H
L
G
-
M
G
L
V
E
G
Y
D
S
-
M
G
Y
E
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
K
L
-
D
E
A
L
-
A
Q
Y
F
G
N
G
T------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
61.50
23%
34
- C2 -
-
5GVE
-
?
A:
[2-601]
----------------------------------------------------------
M
K
T
V
L
M
V
A
E
K
P
S
L
A
Q
S
I
A
K
I
L
--
S
R
G
S
L
S
S
H
K
G
L
N
G
------
A
C
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
F
K
M
T
S
V
C
--
G
H
V
M
T
L
D
F
L
G
K
Y
N
-------
K
W
-------
D
-
K
V
D
P
A
E
----
L
F
S
Q
A
P
T
--
E
K
K
E
A
N
PKL
N
M
V
----
K
F
L
Q
V
E
G
R
G
C
D
Y
I
V
L
W
L
D
C
D
K
E
G
E
N
I
C
F
E
V
L
D
A
V
L
-
P
V
MNKAH
G
G
E
K
T
V
F
R
A
R
F
S
S
I
T
D
T
D
I
C
N
A
M
A
C
L
G
E
P
D
H
--
N
E
A
L
S
V
D
A
R
Q
E
L
D
L
R
I
G
C
A
F
T
R
F
Q
T
K
Y
F
Q
G
---
K
Y
----
G
DLD
S
-
L
I
-
S
F
G
P
C
Q
T
P
T
L
G
F
C
V
E
R
H
D
K
I
Q
S
F
K
P
E
T
Y
W
V
L
Q
A
-
K
V
N
T
D
K
D
R
------
S
--
L
L
L
D
W
D
R
-------------------------
V
R
V
F
D
-
R
E
I
A
Q
M
F
L
N
M
-
T
--
K
----
L
E
-
K
E
A
Q
V
E
A
T
S
R
K
E
K
A
K
Q
R
P
L
A
L
N
T
V
E
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
H
A
M
Q
T
A
E
R
L
Y
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
--
G
S
L
R
Q
Q
A
N
H
P
------
Y
W
A
-
D
T
-
V
K
R
L
L
A
E
-
G
I
N
R
P
R
K
G
H
D
--
A
G
D
-
H
P
P
I
T
P
M
K
S
A
---
T
E
-------
A
E
L
G
G
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
T
V
S
H
D
C
K
Y
L
Q
S
T
I
S
F
R
I
----
G
P
E
L
F
T
C
S
G
K
T
V
--
L
S
P
G
F
T
E
V
M
P
W
Q
S
V
P
--------
L
--
E
E
S
L
P
T
C
Q
R
G
D
A
F
P
-
V
G
E
V
-
K
M
L
E
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
T
L
M
E
-----------------
K
H
G
I
G
T
D
A
S
I
P
V
H
I
N
N
I
C
Q
R
N
Y
V
T
V
E
S
G
R
R
-
L
K
P
T
N
L
G
-
I
V
L
V
H
G
Y
Y
K
-
I
D
A
E
L
V
L
P
T
I
R
S
A
V
E
K
Q
L
N
L
I
A
Q
G
K
A
D
Y
R
Q
V
L
G
H
T
L
D
V
F
K
R
K
F
H
Y
F
V
D
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
60.92
23%
31
- C2 -
-
5GVC
-
?
A:
[2-602]
--------------------------------------------------------
G
H
M
K
T
V
L
M
V
A
E
K
P
S
L
A
Q
S
I
A
K
I
L
--
S
R
G
S
L
S
S
H
K
G
L
N
G
------
A
C
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
F
K
M
T
S
V
C
--
G
H
V
M
T
L
D
F
L
G
----------
K
W
-------
D
-
K
V
D
P
A
E
----
L
F
S
Q
A
P
T
--
E
K
K
E
A
N
PKL
N
M
V
----
K
F
L
Q
V
E
G
R
G
C
D
Y
I
V
L
W
L
D
C
D
K
E
G
E
N
I
C
F
E
V
L
D
A
V
L
-
P
V
MNKAH
G
G
E
K
T
V
F
R
A
R
F
S
S
I
T
D
T
D
I
C
N
A
M
A
C
L
G
E
P
D
H
--
N
E
A
L
S
V
D
A
R
Q
E
L
D
L
R
I
G
C
A
F
T
R
F
Q
T
K
Y
F
Q
G
---
K
Y
----
G
DLD
S
S
L
I
-
S
F
G
P
C
Q
T
P
T
L
G
F
C
V
E
R
H
D
K
I
Q
S
F
K
P
E
T
Y
W
V
L
Q
A
-
K
V
N
T
D
K
D
R
------
S
--
L
L
L
D
W
D
R
-------------------------
V
R
V
F
D
-
R
E
I
A
Q
M
F
L
N
M
-
T
--
K
----
L
E
-
K
E
A
Q
V
E
A
T
S
R
K
E
K
A
K
Q
R
P
L
A
L
N
T
V
E
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
H
A
M
Q
T
A
E
R
L
Y
T
Q
--------
G
Y
I
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
--
G
S
L
R
Q
Q
A
N
H
P
-------
Y
W
A
D
T
-
V
K
R
L
L
A
E
-
G
I
N
R
P
R
K
G
H
D
--
A
G
D
-
H
P
P
I
T
P
M
K
S
A
---
T
E
-------
A
E
L
G
G
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
T
V
S
H
D
C
K
Y
L
Q
S
T
I
S
F
R
I
----
G
P
E
L
F
T
C
S
G
K
T
V
--
L
S
P
G
F
T
E
V
M
P
W
Q
S
V
P
--------
L
--
E
E
S
L
P
T
C
Q
R
G
D
A
F
P
-
V
G
E
V
-
K
M
L
E
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
T
L
M
E
-----------------
K
H
G
I
G
T
D
A
S
I
P
V
H
I
N
N
I
C
Q
R
N
Y
V
T
V
E
S
G
R
R
-
L
K
P
T
N
L
G
-
I
V
L
V
H
G
Y
Y
K
-
I
D
A
E
L
V
L
P
T
I
R
S
A
V
E
K
Q
L
N
L
I
A
Q
G
K
A
D
Y
R
Q
V
L
G
H
T
L
D
V
F
K
R
K
F
H
Y
F
V
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
57.89
20%
44
- C2 -
-
5D5H
2
TOP1_MYCTU
A:
[19-705]
-----------------------------------------------------------
G
R
R
L
V
I
V
E
S
P
T
K
A
R
K
L
A
S
Y
L
--
G
S
---------------------------------
G
Y
I
V
E
S
S
R
--
G
H
I
R
D
L
P
R
A
A
S
D
V
P
A
K
Y
K
SQ
P
W
-------
A
---
R
L
G
V
N
V
D
A
D
F
E
P
L
Y
I
I
S
P
E
--
K
R
---
S
T
V
----
S
E
L
R
G
L
L
K
D
V
D
E
L
Y
L
A
T
D
G
D
R
E
G
E
A
I
A
W
H
L
L
E
T
L
K
---------
P
R
I
P
V
K
R
M
V
F
H
E
I
T
E
P
A
I
R
A
A
A
E
H
P
R
D
L
D
I
--
D
L
V
D
A
Q
E
T
R
R
I
L
D
R
L
Y
G
Y
E
V
S
P
V
L
W
K
K
V
A
---------------
P
K
L
-
S
A
G
R
V
Q
S
V
A
T
R
I
I
V
A
R
E
R
D
R
M
A
F
R
S
A
A
Y
W
D
I
L
A
-
K
L
D
A
S
V
S
DPDAAPP
T
--
F
S
A
R
L
T
A
VAGRRVATGRDFDSLGTLRKG
D
E
--
V
I
V
L
D
-
E
G
S
A
T
A
L
A
A
G
-
L
-------
D
G
-
T
Q
L
T
V
A
S
A
E
E
K
P
Y
A
R
R
P
Y
P
P
F
M
T
S
T
L
Q
Q
E
A
S
R
K
L
R
F
S
A
E
R
T
M
S
I
A
Q
R
L
Y
E
N
--------
G
Y
I
T
Y
M
R
T
D
S
T
T
L
S
E
S
A
I
----
N
A
A
R
T
Q
A
R
Q
L
--
Y
G
-----
D
E
Y
-
V
A
P
-
A
-
P
-
R
Q
Y
T
R
K
V
K
N
A
--
Q
E
A
-
H
E
A
I
R
P
A
G
E
T
FAT
P
D
A
V
R
R
E
-
L
D
G
P
N
I
D
D
F
R
L
Y
E
L
I
W
Q
R
T
V
A
S
Q
M
A
D
A
R
G
M
T
L
S
L
R
I
T
G
M
SGH
Q
E
V
V
F
S
A
T
G
R
T
L
--
T
F
P
G
F
L
K
A
Y
V
E
T
V
D
E
LV
G
G
E
A
D
D
A
--
E
R
R
L
P
H
L
T
P
G
Q
R
L
D
-
I
V
E
L
-
T
P
D
G
H
A
T
N
P
P
A
R
Y
T
E
A
S
L
V
K
A
L
E
-----------------
E
L
G
I
G
R
P
S
T
Y
S
S
I
I
K
T
I
Q
D
R
G
Y
V
H
K
K
-
G
S
A
-
L
V
P
S
W
V
A
-
F
A
V
T
G
L
L
E
Q
-
H
F
G
R
L
V
D
Y
D
F
T
A
A
M
E
D
E
L
D
E
I
A
A
G
N
E
R
R
T
N
W
L
N
N
F
Y
F
G
G
D
H
G
V
P
D
S
V
A
R
S
G
G
L
K
K
--
L
V
G
I
N
L
E
G
I
-----
D
A
R
E
V
N
S
I
K
L
F
D
D
T
H
G
R
P
I
Y
V
R
VGK
N
G
P
Y
L
E
R
L
V
A
G
DTGEP
T
P
Q
R
A
N
L
S
D
S
I
T
P
D
E
L
T
L
Q
V
A
E
E
L
F
A
-------------------------------------------------------------
37
HHSearch
57.75
23%
44
- C2 -
-
1MW9
-
TOP1_ECOLI
X:
[2-581]
-----------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
--
G
S
---------------------------------
D
Y
V
V
K
S
S
V
--
G
H
I
R
D
L
P
T
--------------ERGALVN
R
-
M
G
V
D
P
W
H
N
-
W
E
A
H
Y
E
V
L
--
P
G
--
K
E
---
K
V
V
----
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
-
G
-------
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
--
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
---------------
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
-
S
T
T
T
P
S
G
E------
A
LA
L
Q
V
T
H
Q
N
----------------------
D
KP
F
R
P
V
N
-
K
E
Q
T
Q
A
A
V
S
L
-
L
-------
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
----
N
M
V
R
G
Y
I
S
D
N
--
F
-----
G
K
K
Y
-
L
-----
P
-
E
S
P
N
Q
Y
A
---------
R
E
A
I
R
P
S
D
V
N
---
V
M
A
E
--
S
-
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
-----------
E
--
D
R
I
L
P
A
V
N
K
G
D
A
L
T
-
L
V
E
L
-
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
-
E
I
V
T
D
R
L
E
E
-
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.68
24%
-1
* C2 *
-
2GAJ
-
TOP1_THEMA
A:
[7-588]
-------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
--
G
N
---------------------------------
E
Y
E
V
F
A
S
M
--
G
H
I
I
D
L
P
K
S
K
------
F
---
G
V
-------
D
-
L
E
-
K
D
F
E
----
P
E
F
A
V
I
--
K
G
--
K
E
---
K
V
V
----
E
K
L
K
D
L
A
K
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
---------
T
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
--
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
---------------
S
N
L
-
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
-
N
F
D
G
L
T
A
-----------
E
I
D
V
K
E
-------------------------
K
K
F
F
D
-
A
E
T
L
K
E
I
Q
S
I
------------
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
----
E
E
A
R
N
L
I
T
E
V
--
F
G
-----
E
E
Y
-
V
G
--------------------
A
-
H
E
A
I
R
P
T
N
V
F
---
M
T
P
E
--
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
----
K
D
G
K
Y
R
F
K
G
T
V
L
K
K
I
F
D
G
Y
E
K
V
W
K
T
E
R
-------------
N
T
G
E
F
P
F
E
E
G
E
S
V
K
-
P
V
V
V
-
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
-
L
Y
P
T
I
V
G
-
S
V
V
M
D
Y
L
E
K
-
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
------------------------
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
----------
C
G
K
T
R
S
V
K
N
----------------------------------------------------------------------------
8
PsiBlast_PDB
57.36
25%
34
- C2 -
-
4RUL
1
TOP1_ECOLI
A:
[85-621]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
--
P
G
--
K
E
---
K
V
V
----
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
-
G
-------
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
--------
K
K
----
I
---
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
-
S
T
T
T
P
S
G
-------
E
--
A
L
A
L
Q
V
T
----------------------
H
--
Q
N
D
K
P
-
F
R
P
V
N
K
E
Q
T
Q
-
A
A
V
S
L
---
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
----
N
M
V
R
G
Y
I
S
D
N
FG
K
K
--
Y
L
P
-------------
E
S
P
N
Q
Y
A
S
K
---
Q
E
A
H
E
A
I
R
P
S
D
V
N
---
V
M
A
E
--
S
-
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
R
K
G
-------
D
E
--
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
-
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
-----------------
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
-
F
-
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
-------
H
F
F
S
D
F
T
Q
Q
L
D
K
A
-
E
--
K
-
D
P
E
E
G
G
M
-
R
P
N
Q
M
V
L
T
S
I
D
----
C
P
T
C
G
R
---------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.30
26%
30
- C2 -
-
3PWT
-
TOP1_ECOLI
A:
[83-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
--
P
G
--
K
E
---
K
V
V
----
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
I
-
G
------
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
--------
K
K
----
I
---
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
-
S
T
T
T
P
S
G
-------
E
--
A
L
A
L
Q
V
T
----------------------
H
--
Q
N
D
K
P
-
F
R
P
V
N
K
E
Q
T
Q
-
A
A
V
S
L
---
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
----
N
M
V
R
G
Y
I
S
D
N
FG
K
K
--
Y
L
P
-------------
E
S
P
N
Q
Y
A
-------A
H
E
A
I
R
P
S
D
V
N
---
V
M
A
E
--
S
-
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
R
----------
E
--
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
-
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
-----------------
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
-
F
-
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
-------
H
F
F
S
D
F
T
Q
Q
L
D
K
A
-
E
--
K
-
D
P
E
E
G
G
M
-
R
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.88
26%
38
- C2 -
-
1MW8
2
TOP1_ECOLI
X:
[83-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
--
P
G
--
K
E
---
K
V
V
----
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
I
-
G
------
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
--------
K
K
----
I
---
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
-
S
T
T
T
P
S
G
-------
E
--
A
L
A
L
Q
V
T
----------------------
H
--
Q
N
D
K
P
-
F
R
P
V
N
K
E
Q
T
Q
-
A
A
V
S
L---
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
----
N
M
V
R
G
Y
I
S
D
N
FG
K
K
--
Y
L
P
-------------
E
S
P
N
Q
Y
A
S
-----
E
A
R
E
A
I
R
P
S
D
V
N
---
V
M
A
E
--
S
-
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
------------
E
--
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
-
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
-----------------
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
-
F
-
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
-------
H
F
F
S
D
F
T
Q
Q
L
D
K
A
-
E
--
K
-
D
P
E
E
G
G
M
-
R
-----------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.75
26%
35
- C2 -
-
1MW9
-
TOP1_ECOLI
X:
[83-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
--
P
G
--
K
E
---
K
V
V
----
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
-
L
R
E
V
I
-
G
------
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
--------
K
K
----
I
---
A
R
G
L
-
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
-
S
T
T
T
P
S
G
-------
E
--
A
L
A
L
Q
V
T
----------------------
H
--
Q
N
D
K
P
-
F
R
P
V
N
K
E
Q
T
Q
-
A
A
V
S
L---
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
----
N
M
V
R
G
Y
I
S
D
N
FG
K
K
--
Y
L
P
-------------
E
S
P
N
Q
Y
A
--------
R
E
A
I
R
P
S
D
V
N
---
V
M
A
E
--
S
-
L
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
----
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
G
W
T
K
V
M
P
A
L
-----------
E
--
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
-
E
L
-
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
-----------------
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
-
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
-
F
-
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
-------
H
F
F
S
D
F
T
Q
Q
L
D
K
A
-
E
--
K
-
D
P
E
E
G
G
M
-
R
-----------------------------------------------------------------------------------------------------------------------------------