@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWT3: (2017-12-31 )
MANEQTRSSRRQKQPTPKKSVKKNSGKGSGKSSGTHKKGLFIKILLGILSFFCILFLAGVGLFWYYAKDAPELTDKKLDATVSSKLYTQDGELFEDLGAEKREKISANELPKTLEDAIVSVEDRRFYKHIGVDPIRIIGSALSNFTSGGLQGGSTLTQQLIKLSFFSTSAEDQTLKRKAQEAWMAVRLEQKKSKQEILTYYVNKVYMSNGLYGMETASEMYFGKKLSELSLPQTALLAGMPQAPSAYDPYVYPDQAKKRRDTVLYTMLQNEKISQTEYDQAVNVPVTDGLQELTQSDDNTKIVDNYVKEVINEVQEKTDKNVYTDGLEIYTNLDLDAQKKLYDIVNTDQYVSYPDDEMQVASTLIDTNTGKVKAQIGGRHIAEDVTLGNNLAVNTSRDFGSTMKPVTDYGPAFEYLKYSTGKTITDAPYNYEGTSTPVGNWDNQYMGTITLRQALYLSRNVPAVKLFNEVGSDKVASFLKNLGIEYSTIHQSNAISSNTEEQDGTKYGASSLKMAAAYAAFANGGTYYKPQYVNKIVFQDGTEETYEPDGKTAMSPETAYMITDILKDTITEGTGTNAQIAGLYQAGKTGTSNYTDDEYAKLGISSGVYPDILFAGYTPNYSISVWTGYNKKMTPVTSESSHVASDVYRELMQYVSANVTNTDWEMPSGLIRVGGELYYKDQYTARSNAITPSTTIPSSSYVQTPGSSTTETTTQSSSSTSQSESTAESSKESTTAETSEPASSTTVPSSSSEESSTPSSSAPPASSSEPATSGADAANDHTPSSSTSASGNR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70......-..80........90......-.---.-100.......110.......120.......130.......140......-.150.......160.......170.......180....---...190.......200.......210--.........220.......230.......240.......250.......260.......270.......--280.......290------...-..------....300----.......-.310----....---..------.320.........330.......340......-------------------------------------------------.-350.----------------------------------------------------------------------------------------------------------.----...--.------------------------------------------------.360.......370.......380.......390.......400.......410.....-.-.420.....-..-.430---.---......440....--...450.......460.......470--.........480....-.--..490.......500.......510.......520.......530.......540...-.-------------.--.------------------------------.550.......560.......570------.-......--.-580.......590.......600..-....-..610.......620.......630....----.--...-640.......650.......660...---....670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAN
E
Q
T
R
S
SRRQKQPT
P
K
K
SVKKNSGKGSGKSSGTHKK
G
L
F
I
K
I
L
L
G
I
L
S
F
F
C
I
L
F
L
A
G
V
G
L
F
W
Y
YAKDAPEL
T
D
K
K
-
L
D
A
T
VSS
K
L
YTQD
G
E
L
F
E
D
L-G---
A
-
E
K
R
E
KI
S
A
N
E
L
P
K
T
L
E
D
A
I
VSV
E
D
R
R
F
Y
K
H
IGV
D
P
I
R
I
I
G
S
A
L
S
N
FTSG-GLQG
G
S
T
L
T
Q
Q
L
I
K
L
SFFSTSAE
D
Q
T
L
K
R
K
A
Q
E
A
W
M
A
V
---
R
L
E
Q
KK
S
K
Q
E
I
L
T
Y
Y
V
N
K
V
Y
MSNG----LYGM
E
T
A
S
E
M
Y
F
G
K
K
L
S
ELSL
P
Q
T
A
L
LAGMPQAPSAYDPYVY
P
D
Q
A
KKRRD
T
V
L
Y
T
MLQNEKISQTEYD--QAVNVPV
T
D
G
L
--------
Q
E
L
-TQ------SDDN
T
K
-----
I
V
D
N
Y
V
K
-
E
V
I
N
----
E
V
Q
E
---
K
T------DK--NVYTD
G
L
E
I
Y
TNLD
L
D
A
Q
K
K
L
Y
D
I
VNTD-------------------------------------------------Q-YVSY----------------------------------------------------------------------------------------------------------P----
D
D
E
--
M
------------------------------------------------
Q
V
A
S
T
L
IDTNT
G
K
V
K
A
QIGG
R
H
IAEDVTLGN
N
L
A
V
NTSRDFGSTMKPVTDYGP
A
F
E
Y
LK-Y-STG-
K
T
ITD-AP-YNYE---G---TSTPVGNWDN
Q
Y
M
--
G
T
I
T
L
R
Q
A
L
Y
LSRNV
P
A
V
K
L
F
N
E
V----G
S
D
K
V
A
S
F
L
K
NLGI
E
Y
-
S
--
T
I
HQSNAISSNTEEQDGTKY
G
A
S
S
L
K
M
A
A
A
Y
A
AFANGGTYY
K
P
Q
Y
V
N
K
I
V
FQDGTEET-Y-------------E--P------------------------------DGKTAMSP
E
T
A
Y
M
I
T
D
I
L
K
D
T
I
T-------E-GTGTN
A
--
Q
-
I
A
G
L
Y
QAGKTGTSNYT
D
D
E
Y
A
-KLG-ISSG-VYPD
I
L
F
AGYTP
N
Y
S
I
S
V
W
TGYNK-KMTP----V--TSE-S
S
H
V
A
S
D
V
Y
R
E
L
M
Q
Y
V
SANVTNTDWE---MPS
G
L
I
RVG
G
E
L
Y
Y
K
DQYTARSNAITPSTTIPSS
S
Y
V
QTPGSST
T
E
T
T
TQSSSSTSQSESTAESSKESTTAETSEPASSTTVPSSSSEESSTPSSSAPPASSSEPATSGADAANDHTPSSSTSASGNR
5
PsiBlast_PDB
76.95
54%
-2
- C2 -
-
2V2F
1
?
F:
[9-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
Q
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
S
D
-------------------------------------------------
Q
-
Y
V
S
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
D
--
L
------------------------------------------------
Q
V
A
S
T
V
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
-----
S
F
G
T
N
Q
A
V
E
T
N
R
D
W
G
S
A
M
K
P
I
T
D
Y
A
P
A
I
E
Y
G
V
-
Y
D
S
T
A
-
T
M
V
N
D
-
I
P
-
Y
N
Y
P
---
G
---
T
S
T
P
V
Y
N
W
D
R
A
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
T
A
V
E
T
L
N
K
V
----
G
L
D
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
M
H
Y
A
N
A
I
S
S
N
T
T
E
S
N
-
K
Q
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
I
Y
H
K
P
M
Y
I
N
K
V
V
F
S
D
G
S
K
K
E
-
F
-------------
S
--
D
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
E
M
M
K
T
V
L
A
-------
Y
-
G
T
G
R
G
A
--
Y
-
L
P
W
L
A
Q
A
G
K
T
G
T
S
N
Y
T
D
-------------Y
V
A
P
D
E
M
F
V
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
I
--
V
G
D
-
G
F
L
V
A
A
K
V
Y
R
S
M
I
T
Y
L
S
E
G
S
-
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.79
57%
1
- C2 -
-
2C6W
-
?
B:
[6-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
D
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
T
-------
Y
-
G
T
G
R
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.71
57%
2
- C2 -
-
2C5W
3
?
B:
[7-385]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
E
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
T
-------
Y
-
G
T
G
R
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.60
56%
3
- C2 -
-
2ZC6
1
?
D:
[9-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
D
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
S
-------
Y
-
G
T
G
Q
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.38
56%
2
- C2 -
-
2ZC5
1
?
D:
[9-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
D
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
S
-------
Y
-
G
T
G
Q
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.23
56%
2
- C2 -
-
2ZC6
1
?
B:
[9-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
D
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
S
-------
Y
-
G
T
G
Q
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
35
HHSearch
76.02
34%
66
- C2 -
-
3DWK
-
?
C:
[4-602]
--------------------------------------------------------------------------------
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
-
D
---
N
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
N
L
T
G
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
---
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
--------
V
N
R
-
T
P
E
E
R
Q
NI
D
T
N
Q
D
S
-----
E
Y
N
S
Y
V
N
-
F
V
K
S
----
E
L
M
N
---
N
K
AFKDEN
L
G
--
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
-------------------------------------------------
S
-
F
Y
------------------------------------------------------------------------------------------------------------
K
----
N
K
D
--
Q
------------------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
V
--
V
N
R
N
Q
A
T
D
-
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
K
-
W
-
A
T
N
-
H
A
I
Q
D
-
E
S
-
S
Y
Q
V
---
D
----
G
S
T
F
R
N
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
N
A
G
N
D
A
P
K
K
F
A
A
K
L
G
L
N
Y
-
E
G
-
D
I
G
P
S
E
V
L
G
G
S
A
S
-------
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
-------------
D
--
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
P------
Y
-
G
S
A
Y
G
H
--
G
-
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
-
Q
Y
N
-
L
P
D
N
-
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
-
V
K
Q
Y
GENS
F
V-
G
H
S
-
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
G
E
D
F
K
---
R
P
S
S
V
---------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.80
56%
1
- C2 -
-
2ZC5
1
?
B:
[9-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
N
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
D
S
T
A
-
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
T
T
E
S
D
-
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
S
-------
Y
-
G
T
G
Q
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
N
H
I
K
-
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
-
N
G
E
F
V
F
K
N
----------------------------------------------------------------------------------------------------------------
29
HHSearch
75.55
34%
59
* C2 *
-
2OLV
1
?
A:
[9-611]
---------------------------------------------------------------------------
A
K
-
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
-
D
---
N
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
---
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
--------
V
N
R
-
T
P
E
E
R
Q
NI
D
T
N
Q
D
S
-----
E
Y
N
S
Y
V
N
-
F
V
K
S
----
E
L
M
N
---
N
K
AFKDEN
L
G
--
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
-------------------------------------------------
S
-
F
Y
------------------------------------------------------------------------------------------------------------
K
----
N
K
D
--
Q
------------------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
V
--
V
N
R
N
Q
A
T
D
-
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
K
-
W
-
A
T
N
-
H
A
I
Q
D
-
E
S
S
Y
Q
V
D
--------
G
S
T
F
R
N
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
NA
G
N
D
A
P
K
K
F
A
A
K
L
G
L
N
Y
-
E
G-
D
I
G
P
S
E
V
L
G
G
S
A
S
-------
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
-------------
D
--
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
P------
Y
-
G
S
A
Y
G
H
--
G
-
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
-
Q
Y
N
-
L
P
D
N
-
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
-
V
K
Q
Y
GENS
F
V-
G
H
S
-
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
G
E
D
F
K
---
R
P
S
S
V
---------------------------------------------------------------------------------------------------------------------------
46
HHSearch
75.35
57%
-2
- C2 -
-
2C6W
-
?
B:
[9-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
K
-
E
V
I
N
----
Q
V
E
E
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
-------------------------------------------------
E
-
Y
V
A
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
E
--
L
------------------------------------------------
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
Q
S
S
N
V
S
F
G
I
N
Q
A
V
E
T
N
R
D
W
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
V
-
Y
-
D
S
T
A
T
I
V
H
D
-
E
P
-
Y
N
Y
P
---
G
---
T
N
T
P
V
Y
N
W
D
R
G
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
L
N
K
V
----
G
L
N
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
I
H
Y
S
N
A
I
S
S
N
-
T
T
E
S
D
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
K
E
-
F
-------------
S
--
N
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
D
M
M
K
T
V
L
T
-------
Y
-
G
T
G
R
N
A
--
Y
-
L
A
W
L
P
Q
A
G
K
T
G
T
S
N
Y
T
D
E
E
I
E
-
N
H
I
K
T
S
Q
F
-
V
A
P
D
E
L
F
A
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
L
--
V
G
N
-
G
L
T
V
A
A
K
V
Y
R
S
M
M
T
Y
L
S
E
G
S
N
P
E
D
W
N
---
I
P
E
G
L
Y
R
N
------------------------------------------------------------------------------------------------------------------------
57
Fugue
73.25
28%
2
- C2 -
-
3UDI
1
?
A:
[19-727]
------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
Q
V
Y
T
A
------------
D
N
Q
L
I
A
E
Y
G
G
K
L
S
I
P
V
E
---
Y
K
Q
I
P
P
N
F
I
H
A
F
L
A
A
EDS
S
F
F
Q
N
L
S
K
E
D
I
L
S
L
Y
V
N
K
I
F
L
G
K
N
----
A
Y
G
I
A
A
A
A
K
I
Y
Y
N
K
S
I
N
E
L
S
I
A
Q
M
A
M
I
A
G
L
P
K
A
P
S
K
Y
N
P
V
V
N
P
E
R
A
L
E
R
R
N
W
I
L
G
R
M
L
Q
L
G
Y
I
S
Q
A
E
Y
Q
--
K
A
V
A
E
P
I
N
L
N
M
--------
P
N
R
-
D
L
------
N
N
I
H
---------
P
Y
A
G
E
-
M
V
R
S
----
E
L
V
K
---
H
F
------
G
E
--
Q
A
I
D
S
G
Y
K
V
Y
T
T
I
N
A
K
R
Q
A
I
A
E
K
A
V
Q
D
G
L
E
A
Y
D
R
R
H
GWRGAEAHDKPLSEFRAYAN
T
Y
P
A
Q
V
T
K
VNSS
S
F
E
A
L
M
QDG
S
-
T
V
T
V
----------------------------------------------------------------------------------------------------------
Q
----
W
S
G
--
M
SWARPYRNANSVGAAPSRASQIVKVK
D
I
V
R
L
R
P
N
EAKT
A
W
S
L
V
Q
V
P
K
V
Q
G
Q
L
I
A
I
N
P
N
D
G
S
I
E
A
I
V
G
G
Y
N
F
Y
Q
S
---
K
F
N
R
A
L
Q
G
W
R
Q
P
G
S
T
I
K
P
F
L
-
Y
A
L
A
L
E
R
-
G
-
M
-
T
P
Y
-
S
M
V
N
D
-
S
P
-
I
T
I
G
---
K
---
W
T
P
K
--
N
S
D
G
R
Y
L
--
G
M
I
P
L
R
R
A
L
Y
L
S
R
N
T
V
S
V
R
L
L
Q
T
V
----
G
I
E
R
T
R
Q
L
F
M
D
F
G
L
Q
E
-
D
--
Q
I
P
R
N
Y
T
I
A
L
G
T
P
Q
-------
V
L
P
I
Q
M
A
T
G
Y
A
T
F
A
N
G
G
Y
R
V
Q
P
H
F
I
Q
R
I
E
D
A
Y
G
K
V
I
Y
-
E
AKPEYACIPCINA
Y
--
R
------------------------------
Q
A
Q
R
I
L
K
S
S
S
A
Y
D
M
A
N
I
L
R
D
V
I
E
-------
H
-
G
T
G
K
I
G
--
R
-
S
D
---
L
G
G
K
T
G
T
T
N
D
A
-----------------
K
D
A
W
F
A
G
F
N
G
K
L
V
T
V
T
W
V
G
F
D
Q
-
P
T
T
L
----
G
--
R
R
E
Y
G
G
I
A
A
L
P
I
W
I
N
F
M
G
Q
A
L
Q
G
T
P
A
A
W
V
R
---
L
E
------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
73.21
28%
25
- C2 -
-
5U2G
-
PBPA_HAEIN
B:
[14-805]
----------------------------------------------------------------------------
K
T
V
E
L
Q
Q
P
M
Q
I
Y
T
A
D
G
K
L
I
G
E
V
-
G
---
E
-
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
-----------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
R
----
S
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
--
A
A
L
K
E
P
I
V
A
S
Y
----------
A
-----------
K
F
E
F
-----
R
A
D
Y
V
T
E
-
M
V
R
Q
----
E
M
V
R
R
--
F
G
------
E
E
--
N
A
Y
T
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
-------------------------------------------------
L
-
I
D
-
Y
D
M
R
H
GYR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
----------
Q
----
I
P
A
--
A
------------------------------------------------
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
F
S
Y
E
Q
---
S
K
F
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
I
-
Y
A
A
A
L
E
K
-
G
-
L
-
T
L
S
-
S
V
L
Q
D
-
S
P
-
I
S
I
Q
---
K
PGQ
K
M
W
Q
P
K
N
S
P
D
R
Y
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
Q
T
A
----
G
I
D
F
T
A
E
F
L
Q
R
F
G
F
K
R
-
D
QY
F
A
S
E
A
L
A
L
G
A
A
---------
S
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
-------------
N
--
P
K
I
A
C
IECNDIPVIYGETKDKINGFASS
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
GEQGLDW
K
-
G
T
S
W
R
I
A
Q
S
-
I
K
R
S
D
I
G
G
K
T
G
T
T
N
S
S
-----------------
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
-
N
K
R
V
----
L
GR
G
E
A
-
G
A
K
T
A
-
P
A
W
I
T
Y
-
K
T
A
L
S
D
K
P
E
R
K
L
S
---
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
----
S
P
---
N
G
--
G
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
Y
L
---------------------------------------------------------------------------------
34
HHSearch
73.07
28%
30
- C2 -
-
5U2G
1
PBPA_HAEIN
A:
[14-805]
----------------------------------------------------------------------------
K
T
V
E
L
Q
Q
P
M
Q
I
Y
T
A
D
G
K
L
I
G
E
V
-
G
---
E
-
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
-----------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
R
----
S
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
--
A
A
L
K
E
P
I
V
A
S
-----------------------
K
F
E
F
-----
R
A
D
Y
V
T
E
-
M
V
R
Q
----
E
M
V
R
R
--
F
G
------
E
E
--
N
A
Y
T
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
-------------------------------------------------
L
-
I
D
-
Y
D
M
R
H
GYR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
----------
Q
----
I
P
A
--
A
------------------------------------------------
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
F
S
Y
E
Q
---
S
K
F
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
I
-
Y
A
A
A
L
E
K
-
G
-
L
-
T
L
S
-
S
V
L
Q
D
-
S
P
-
I
S
I
Q
---
K
PGQ
K
M
W
Q
P
K
N
S
P
D
R
Y
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
Q
T
A
----
G
I
D
F
T
A
E
F
L
Q
R
F
G
F
K
R
-
D
QY
F
A
S
E
A
L
A
L
G
A
A
---------
S
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
-------------
N
--
P
KIACIECNDIPVIYGETKDKINGFAS
S
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
GEQGLDW
K
-
G
T
S
W
R
I
A
Q
S
-
I
K
R
S
D
I
G
G
K
T
G
T
T
N
S
S
-----------------
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
-
N
K
R
V
----
L
GR
G
E
A
-
G
A
K
T
A
M
P
A
W
I
T
Y
M
K
T
A
L
S
D
K
P
E
R
K
L
S
---
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
----
S
P
---
N
G
--
G
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
Y
L
---------------------------------------------------------------------------------
6
PsiBlast_PDB
73.01
31%
68
- C2 -
-
2OLU
1
?
A:
[10-634]
----------------------------------------------------------------------------
K
-
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
---
G
-
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
-------------
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
-------
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
VNRT
P
E
E
R
Q
N
I
D
T
N
------
Q
D
S
E
Y
N
-----
S
Y
V
N
F
V
K
S
E
L
M
N
----
N
K
A
F
---
K
D
------
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
-------------------------------------------------
S
-
F
--
Y
----------------------------------------------------------------------------------------------------------
K
----
N
K
D
--
Q
------------------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
V
V
---
N
R
N
Q
A
T
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
K
-
W
-
A
T
N
-
H
A
I
Q
D
E
S
S
-
Y
Q
V
D
---
G
---
S
T
--
F
R
N
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
N
A
G
N
D
A
P
K
K
F
A
A
K
L
G
L
N
Y
E
G
--
D
I
G
P
S
E
V
L
G
G
S
A
S
E
-------
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
-------------
D
--
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
-------
P
Y
G
S
A
Y
G
H
--
G
-
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
-
Q
Y
N
-
L
P
D
N
-
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
G
----
E
--
N
S
F
-
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
D
G
E
DFK
R
P
S
S
V
----------------------
S
G
S
I
P
S
I
N
V
S
G
S
Q
D
N
N
T
T
N
R
S
T
H
------------------------------------------------------------------------------
30
HHSearch
72.85
29%
23
- C2 -
-
5HLB
2
PBPB_ECOLI
A:
[134-717]
-----------------------------------------------------------------------------------
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
-
S
SPN
G
-
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
G
R
A
V
L
A
N
L
T
A
G
R
T
V
Q
G
A
S
T
L
T
Q
Q
L
V
K
N
L
F
L
S
---
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
GD
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
--
M
L
S
A
R
P
L
G
V
Q
P
--------
R
G
G
------------
V
I
S
-----
P
Q
P
A
F
M
Q
-
L
V
R
Q
----
E
L
Q
A
K
--
L
G
------
D
K
--
V
K
D
L
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
K
A
A
V
E
G
-------------------------------------------------
I
-
P
A
-
L
----------------------------------------------------------------------------------------------------------
K
K
Q
R
K
L
S
D
--
L
------------------------------------------------
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
S
E
P
Q
---
F
A
G
Y
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
T
-
Y
L
T
A
L
S
Q
P
K
I
Y
-
R
L
N
-
T
W
I
A
D
-
A
P
-
I
A
L
R
Q
PN
G
---
Q
V
W
S
P
Q
N
D
D
R
R
Y
S
ES
G
R
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
M
A
L
----
G
L
P
A
V
T
E
T
W
I
K
L
G
V
P
K
-
D
QL
H
P
V
P
A
M
L
L
G
A
L
---------
N
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
-------------
F
--
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
-------
R
-
G
T
G
R
Q
L
G
A
K
-
Y
P
N
L
H
L
A
G
K
T
G
T
T
N
N
N
-----------------
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
-
N
Q
P
-----
T
--
K
L
Y
-
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
Q
T
P
--
T
P
L
N
L
V
---
P
P
E
D
I
A
D
M
G
V
D
Y
D
G
N
F
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.36
31%
67
- C2 -
-
2OLV
1
?
A:
[9-634]
---------------------------------------------------------------------------
A
K
-
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
---
G
-
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
---
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
--
D
A
K
K
I
D
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
N
I
D
T
N
------
Q
D
S
E
Y
N
-----
S
Y
V
N
F
V
K
S
E
L
M
N
----
N
K
A
F
---
K
D
------
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
-------------------------------------------------
S
-
F
--
Y
----------------------------------------------------------------------------------------------------------
K
----
N
K
D
--
Q
------------------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
V
V
---
N
R
N
Q
A
T
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
K
-
W
-
A
T
N
-
H
A
I
Q
D
E
S
S
-
Y
Q
V
D
---
G
---
S
T
--
F
R
N
Y
D
T
K
S
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
Q
S
V
K
Q
NA
G
N
D
A
P
K
K
F
A
A
K
L
G
L
N
Y
E
G
--
D
I
G
P
S
E
V
L
G
G
S
A
S
E
-------
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-
Y
-------------
D
--
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
-------
P
Y
G
S
A
Y
G
H
--
G
-
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
-
Q
Y
N
-
L
P
D
N
-
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
G
----
E
--
N
S
F
-
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
D
G
E
DFK
R
P
S
S
V
----------------------
S
G
S
I
P
S
I
N
V
S
G
S
Q
D
N
N
T
T
N
R
S
T
H
------------------------------------------------------------------------------
50
HHSearch
71.90
52%
28
- C2 -
-
2V2F
1
?
F:
[5-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
A
Y
M
D
-
N
Y
L
K
EVIN
Q
V
E
Q
---
E
T
------
G
Y
--
N
L
L
T
T
G
M
D
V
Y
T
N
V
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
S
D
-------------------------------------------------
Q
-
Y
V
S
Y
----------------------------------------------------------------------------------------------------------
P
----
D
D
D
--
L
------------------------------------------------
Q
V
A
S
T
V
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
H
-----
S
F
G
T
N
Q
A
V
E
T
N
R
D
W
G
S
A
M
K
P
I
T
D
Y
A
P
A
I
E
Y
G
V
-
Y
-
D
S
T
A
T
M
V
N
D
-
I
P
-
Y
N
Y
P
---
G
---
T
S
T
P
V
Y
N
W
D
R
A
Y
F
--
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
T
A
V
E
T
L
N
K
V
----
G
L
D
R
A
K
T
F
L
N
G
L
G
I
D
Y
-
P
--
S
M
H
Y
A
N
A
I
S
S
N
T
T
E
S
N
K
Q
-
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
I
Y
H
K
P
M
Y
I
N
K
V
V
F
S
D
G
S
K
K
E
-
F
-------------
S
--
D
------------------------------
V
G
T
R
A
M
K
E
T
T
A
Y
M
M
T
E
M
M
K
T
V
L
A
-------
Y
-
G
T
G
R
G
A
--
Y
-
L
P
W
L
A
Q
A
G
K
T
G
T
S
N
Y
T
D
------------
Y
-
V
A
P
D
E
M
F
V
G
Y
T
R
K
Y
S
M
A
V
W
T
G
Y
S
N
-
R
L
T
P
----
I
--
V
G
D
-
G
F
L
V
A
A
K
V
Y
R
S
M
I
T
Y
L
S
E
G
S
-
P
E
D
W
N
---
I
P
E
G
L
Y
R
N
G
-----------------------------------------------------------------------------------------------------------------------
32
HHSearch
65.35
28%
22
- C2 -
-
4OON
1
PBPA_PSEAE
A:
[20-765]
-----------------------------------------------------------------------------------
P
L
K
V
Y
S
E
D
G
K
L
I
S
E
F
-
G
---
E
-
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------
P
E
L
-----
N
A
P
Y
I
A
E
-
M
A
R
A
----
E
M
V
G
---
R
Y
------
G
S
--
E
A
Y
T
E
G
Y
K
V
I
T
T
V
R
S
D
L
Q
N
A
A
S
Q
S
V
R
D
G
-------------------------------------------------
L
-
I
D
-
Y
D
Q
R
H
GYRGPE
T
R
L
P
GQT
R
D
A
W
L
K
H
L
G
Q
Q
R
S
I
GG
L
E
P
A
I
V
TQVEKS
G
I
M
V
M
T
RDG
K
E
E
A
V
T
WDSMKWARPFLSNNSMGPMPRQPADVAQAG
D
Q
I
R
V
Q
R
Q
EDGTL
R
F
V
Q
----
I
P
A
--
A
------------------------------------------------
Q
S
A
L
I
S
L
D
P
K
D
G
A
I
R
S
L
V
G
G
F
S
F
E
Q
---
S
N
Y
N
R
A
I
Q
A
K
R
Q
P
G
S
S
F
K
P
F
I
-
Y
S
A
A
L
D
N
-
G
-
F
-
T
A
A
-
S
L
V
N
D
-
A
P
-
I
V
F
V
---
D
E
Y
L----------
T
F
L
--
G
P
I
P
L
R
E
A
L
Y
K
S
R
N
M
V
S
I
R
V
L
Q
G
L
----
G
I
E
R
A
I
S
Y
I
T
K
F
G
F
Q
R
-
D
EL
P
R
N
F
S
L
A
L
G
T
A
---------
T
V
T
P
M
E
I
A
G
A
W
S
V
F
A
N
G
G
Y
K
V
N
P
Y
V
I
E
R
I
E
S
R
D
G
Q
V
L
Y
Q
A
-------------
N
--
P
PRVPVE
P
T
----------------------
P
A
E
R
I
I
D
A
R
T
A
Y
I
M
T
S
M
L
Q
D
V
I
K
-------
R
-
G
T
G
R
R
A
--
L
A
L
K
R
T
D
L
A
G
K
T
G
T
T
N
D
S
-----------------
K
D
G
W
F
S
G
Y
N
S
D
Y
V
T
S
V
W
V
G
F
D
Q
-
P
E
T
L
G---
R
--
R
E
Y
-
G
G
T
V
A
L
P
I
W
I
R
Y
M
G
F
A
L
K
D
K
P
M
H
T
M
A
---
E
P
P
G
I
V
S
L
R
I
D
P
V
T
G
R
----
S
A
A
P
G
T
P
G
A
--
Y
F
E
M
F
K
N
E
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.98
35%
44
- C2 -
-
3ZGA
4
?
B:
[7-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
A
T
K
I
V
L
N
D
---------------
Q
------
S
K
D
P
L
A
NKY
P
W
Y
V
D
A
V
I
N
-
E
A
V
N
----
E
A
-
D
---
I
T
------
Q
D
--
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
-------------------------------------------------
G
L
F
P
S
N
----------------------------------------------------------------------------------------------------------
A
----
N
D
G
TL
V
------------------------------------------------
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
--
G
E
H
V
F
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
T
P
A
L
Q
S
-
G
-
Y
-
D
V
D
-
S
M
L
K
D
-
E
K
-
I
T
Y
K
---
G
---
N
Y
T
P
T
-
N
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
G
I
T
V
-
P
--
E
K
D
R
T
L
G
L
A
L
G
-----
G
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
-
T
V
-
Y
-------------
E
NV
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-------
T
-
G
T
G
Q
S
A
--
A
-
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
P
F
D
D
--------
T
S
G
-
T
-
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
64.76
33%
35
- C2 -
-
3ZG8
4
?
B:
[7-464]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
--
K
Y
K
A
T
K
I
V
L
N
D
--------
Q
S
K
-
D
---------
P
L
A
N
-----
K
Y
P
W
Y
V
D
-
A
V
I
N
----
E
A
V
N
EAD
I
T
------
Q
D
--
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
-------------------------------------------------
G
-
L
F
P
S
NAN-------------------------------------------------------------------------------------------------------
D
----
G
T
L
--
V
------------------------------------------------
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
--
F
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
T
P
A
L
Q
S
G
--
Y
-
D
V
D
-
S
M
L
K
D
-
E
K
-
I
T
Y
K
---
G
----
N
Y
T
P
T
N
V
G
G
V
Y
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
D
Q
I
----
G
I
D
K
G
V
K
S
V
E
K
F
G
I
T
V
-
P
EK
D
R
T
L
G
L
A
L
G
G
M
S
K
-------
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
-------------
V
--
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
-------
T
-
G
T
G
Q
S
A
--
A
-
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
P
F
D
D
---------
T
S
-
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
-
T
D
K
E
HY--
L
--
T
T
T
-
S
S
A
G
V
S
S
L
A
H
Y
V
M
N
S
G
L
Q
Y
Q
-----------------------------------------------------------------------------------------------------------------------------------------